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Articles 25441 - 25470 of 255931
Full-Text Articles in Life Sciences
Implications Of The Net Zero Transition Scenarios On Sdg Indicators: Linking Global Energy System, Cge And Atmospheric Source-Receptor Models, Maksym Chepeliev, George Giannakidis, Amit Kanudia, Dominique Van Der Mensbrugghe
Implications Of The Net Zero Transition Scenarios On Sdg Indicators: Linking Global Energy System, Cge And Atmospheric Source-Receptor Models, Maksym Chepeliev, George Giannakidis, Amit Kanudia, Dominique Van Der Mensbrugghe
Department of Agricultural Economics Faculty Publications
This study contributes to a better understanding of synergies and trade-offs between climate mitigation and sustainable development goals, covering 17 indicators across various SDGs. Our assessment employs a multi-model framework, which includes a global computable general equilibrium model (ENVISAGE), an energy system model (KINESYS) and an atmospheric source-receptor model (TM5-FASST). This combination of modeling tools allows us to provide a detailed representation of the energy-related SDG indicators while accounting for their interactions with climate mitigation and socio-economic dimensions. We find that out of 17 analyzed SDG indicators, seven experience co-benefits from implementing mitigation efforts (including improved environmental footprints, energy efficiency …
Diet Specialization Mediates Drivers Of Cucurbita Herbivory In A Semi-Arid Agroecosystem, Hannah L. Gray, Nicholas A. Ivers, Elizabeth Lopez, Brad G. Peter, Scott D. Longing, Magarita M. Lopez-Uribe, Shalene Jha
Diet Specialization Mediates Drivers Of Cucurbita Herbivory In A Semi-Arid Agroecosystem, Hannah L. Gray, Nicholas A. Ivers, Elizabeth Lopez, Brad G. Peter, Scott D. Longing, Magarita M. Lopez-Uribe, Shalene Jha
Geosciences Faculty Publications and Presentations
Herbivory is a major fitness pressure for plants and a key driver of crop losses in agroecosystems. Dense monocultures are expected to favor specialist herbivorous insects, particularly those who primarily consume crop species; yet, levels and types of herbivory are not uniform within regional cropping systems. It is essential to determine which local and regional ecological factors drive variation in herbivory in order to support functional agroecosystems that rely less on chemical inputs. Crops in the genus Cucurbita host a suite of both generalist and specialist herbivores that inflict significant damage, yet little is known about the relative contribution of …
Hidden Scientists/Hidden Creatives, Con Kennedy
Hidden Scientists/Hidden Creatives, Con Kennedy
Conference Presentations
This presentation discussed how the UN Sustainable Development Goals (SDGs) were integrated into an existing graphic design module delivered on the BA in Visual Communication Design in a joint project with the TU Dublin School of Art and Design, School of Biological, Health and Sports Sciences Sustainability and Research Hub Research, the Ethics and Integrity Office. The project explored underrepresented women in science and graphic design.
Germ Cell Tumor Of The Testis: Lethal Subtypes Of A Curable Cancer, Jamaal C Jackson, Darren Sanchez, Andrew C Johns, Matthew T Campbell, Ahmet M Aydin, Sanjay Maraboyina, John F Ward, Louis L Pisters, Niki M Zacharias, Charles C Guo, Shi-Ming Tu
Germ Cell Tumor Of The Testis: Lethal Subtypes Of A Curable Cancer, Jamaal C Jackson, Darren Sanchez, Andrew C Johns, Matthew T Campbell, Ahmet M Aydin, Sanjay Maraboyina, John F Ward, Louis L Pisters, Niki M Zacharias, Charles C Guo, Shi-Ming Tu
Faculty, Staff and Student Publications
Germ cell tumor of the testis (GCT) is a curable cancer even when it is widely metastatic; however, outcomes can differ based on tumor histology. Chemo-resistance in certain phenotypes, such as teratoma and yolk sac tumor, contributes to poor clinical outcomes in some patients with GCT. Despite this resistance to S-YSTemic therapy, many of these tumor subtypes remain amenable to surgical resection and possible cure. In this study, we report on a series of seven patients highlighting two chemo-resistant subtypes of nonseminomatous germ cell tumor (NSGCT), sarcomatoid yolk sac tumor (S-YST), and epithelioid trophoblastic tumor (ETT) for which early resection …
Structural Analysis Of The Female Reptile Reproductive System By Micro-Computed Tomography And Optical Coherence Tomography†, Bonnie K Kircher, Michaela A Mccown, Deirdre M Scully, Richard R Behringer, Irina V Larina
Structural Analysis Of The Female Reptile Reproductive System By Micro-Computed Tomography And Optical Coherence Tomography†, Bonnie K Kircher, Michaela A Mccown, Deirdre M Scully, Richard R Behringer, Irina V Larina
Faculty, Staff and Student Publications
Volumetric data provide unprecedented structural insight to the reproductive tract and add vital anatomical context to the relationships between organs. The morphology of the female reproductive tract in non-avian reptiles varies between species, corresponding to a broad range of reproductive modes and providing valuable insight to comparative investigations of reproductive anatomy. However, reproductive studies in reptilian models, such as the brown anole studied here, have historically relied on histological methods to understand the anatomy. While these methods are highly effective for characterizing the cell types present in each organ, histological methods lose the 3D relationships between images and leave the …
Rest-Dependent Downregulation Of Von Hippel-Lindau Tumor Suppressor Promotes Autophagy In Shh-Medulloblastoma, Ashutosh Singh, Donghang Cheng, Jyothishmathi Swaminathan, Yanwen Yang, Yan Zheng, Vidya Gopalakrishnan
Rest-Dependent Downregulation Of Von Hippel-Lindau Tumor Suppressor Promotes Autophagy In Shh-Medulloblastoma, Ashutosh Singh, Donghang Cheng, Jyothishmathi Swaminathan, Yanwen Yang, Yan Zheng, Vidya Gopalakrishnan
Faculty, Staff and Student Publications
The RE1 silencing transcription factor (REST) is a driver of sonic hedgehog (SHH) medulloblastoma genesis. Our previous studies showed that REST enhances cell proliferation, metastasis and vascular growth and blocks neuronal differentiation to drive progression of SHH medulloblastoma tumors. Here, we demonstrate that REST promotes autophagy, a pathway that is found to be significantly enriched in human medulloblastoma tumors relative to normal cerebella. In SHH medulloblastoma tumor xenografts, REST elevation is strongly correlated with increased expression of the hypoxia-inducible factor 1-alpha (HIF1α)-a positive regulator of autophagy, and with reduced expression of the von Hippel-Lindau (VHL) tumor suppressor protein - a …
Small Rna Signatures Of Acute Ischemic Stroke In L1cam Positive Extracellular Vesicles, Bharti Manwani, Nivetha Brathaban, Abiya Baqai, Yashee Munshi, Hilda W Ahnstedt, Kajsa Arkelius, Edilberto Amorim, Fanny M Elahi, Neel S Singhal
Small Rna Signatures Of Acute Ischemic Stroke In L1cam Positive Extracellular Vesicles, Bharti Manwani, Nivetha Brathaban, Abiya Baqai, Yashee Munshi, Hilda W Ahnstedt, Kajsa Arkelius, Edilberto Amorim, Fanny M Elahi, Neel S Singhal
Faculty, Staff and Student Publications
L1CAM-positive extracellular vesicles (L1EV) are an emerging biomarker that may better reflect ongoing neuronal damage than other blood-based biomarkers. The physiological roles and regulation of L1EVs and their small RNA cargoes following stroke is unknown. We sought to characterize L1EV small RNAs following stroke and assess L1EV RNA signatures for diagnosing stroke using weighted gene co-expression network analysis and random forest (RF) machine learning algorithms. Interestingly, small RNA sequencing of plasma L1EVs from patients with stroke and control patients (n = 28) identified micro(mi)RNAs known to be enriched in the brain. Weighted gene co-expression network analysis (WGCNA) revealed small RNA …
Differences In Perceived Energy And Macronutrient Requirements Across Divisions In Ncaa Athletes, K. Michelle Singleton, Andrew Jagim, Jamie Mcallister-Deitrick, Marcos Daou, Chad M. Kerksick
Differences In Perceived Energy And Macronutrient Requirements Across Divisions In Ncaa Athletes, K. Michelle Singleton, Andrew Jagim, Jamie Mcallister-Deitrick, Marcos Daou, Chad M. Kerksick
Faculty Scholarship
Background
Sports nutrition is an impactful component to sports performance. The purpose of the current study was to investigate the sports nutrition knowledge of National Collegiate Athletic Association collegiate athletes and assess self-reported perceived requirements for energy and macronutrient intake. A secondary aim was to evaluate the awareness of physical and emotional perceptions associated with mindful eating.
Methods
Participants included NCAA Division I (DI, n = 45), II (DII, n = 31), and III (DIII, n = 47) athletes. Athletes completed a validated questionnaire designed to assess sports nutrition knowledge and were asked questions about their perceived dietary energy and …
Differences In Perceived Energy And Macronutrient Requirements Across Divisions In Ncaa Athletes, K. Michelle Singleton, Andrew R. Jagim, Jamie Mcallister-Deitrick, Marcos Daou, Chad M. Kerksick
Differences In Perceived Energy And Macronutrient Requirements Across Divisions In Ncaa Athletes, K. Michelle Singleton, Andrew R. Jagim, Jamie Mcallister-Deitrick, Marcos Daou, Chad M. Kerksick
Kinesiology
Background: Sports nutrition is an impactful component to sports performance. The purpose of the current study was to investigate the sports nutrition knowledge of National Collegiate Athletic Association collegiate athletes and assess self-reported perceived requirements for energy and macronutrient intake. A secondary aim was to evaluate the awareness of physical and emotional perceptions associated with mindful eating. Methods: Participants included NCAA Division I (DI, n = 45), II (DII, n = 31), and III (DIII, n = 47) athletes. Athletes completed a validated questionnaire designed to assess sports nutrition knowledge and were asked questions about their perceived dietary energy and …
Frontotemporal Dementia-Like Disease Progression Elicited By Seeded Aggregation And Spread Of Fus, Sonia Vazquez-Sanchez, Britt Tilkin, Fatima Gasset-Rosa, Sitao Zhang, Diana Piol, Melissa Mcalonis-Downes, Jonathan Artates, Noe Govea-Perez, Yana Verresen, Lin Guo, Don Cleveland, James Shorter, Sandrine Da Cruz
Frontotemporal Dementia-Like Disease Progression Elicited By Seeded Aggregation And Spread Of Fus, Sonia Vazquez-Sanchez, Britt Tilkin, Fatima Gasset-Rosa, Sitao Zhang, Diana Piol, Melissa Mcalonis-Downes, Jonathan Artates, Noe Govea-Perez, Yana Verresen, Lin Guo, Don Cleveland, James Shorter, Sandrine Da Cruz
Department of Biochemistry and Molecular Biology Faculty Papers
RNA binding proteins have emerged as central players in the mechanisms of many neurodegenerative diseases. In particular, a proteinopathy of fused in sarcoma (FUS) is present in some instances of familial Amyotrophic lateral sclerosis (ALS) and about 10% of sporadic Frontotemporal lobar degeneration (FTLD). Here we establish that focal injection of sonicated human FUS fibrils into brains of mice in which ALS-linked mutant or wild-type human FUS replaces endogenous mouse FUS is sufficient to induce focal cytoplasmic mislocalization and aggregation of mutant and wild-type FUS which with time spreads to distal regions of the brain. Human FUS fibril-induced FUS aggregation …
Boom, Shake The Room: Seismic Surveys Affect Behaviour And Survival Of Western Rock Lobster, Simon De Lestang, Jason How, Kelvin Rushworth, Christine Erbe
Boom, Shake The Room: Seismic Surveys Affect Behaviour And Survival Of Western Rock Lobster, Simon De Lestang, Jason How, Kelvin Rushworth, Christine Erbe
Fisheries Research Articles
Seismic studies are conducted to investigate subterranean structures for, among other things, indications of petroleum and mineral deposits. Within the marine environment, these studies use sub-surface airguns to create powerful sound waves that penetrate the substrate, with their variable reflection time and strength being used to model seabed densities, structure, and composition. There is a growing body of work examining the effects of seismic surveys on marine fauna, primarily marine mammals and to a lesser extent fishes and invertebrates. Recently published studies on the southern rock lobster have shown these intense sound waves can affect lobster physiology and short-term behaviour. …
The Aquatic Microbial Environment Shapes The Gut Microbiota, Brain, And Behavior Of Larval Amphibians, Kyle Emerson
The Aquatic Microbial Environment Shapes The Gut Microbiota, Brain, And Behavior Of Larval Amphibians, Kyle Emerson
Electronic Theses and Dissertations
Microbial communities comprising bacteria, viruses, fungi, and protists live within and on the surfaces of animal hosts. These microbial communities exist in symbiosis with the host, and heavily influence host physiology, development, health, and fitness. Gut-dwelling microbes (i.e., gut microbiota) contribute to host neurodevelopment through a bidirectional Microbiota-Gut-Brain (MGB) axis. Evidence of the MGB axis has been primarily derived from studies that use germ-free (GF) models, which commonly display altered neurophysiology and behavior compared to conventionally raised counterparts. Almost all studies of the MGB axis have used mammalian models in a biomedical framework, leaving a knowledge gap regarding the role …
Heavy Metals Implications To Sediment Microbiome And Coral Response To Arsenic Dosing, Dimitrios G. Giarikos, Amy Hirons, Jose V. Lopez, Abigail Renegar, Jason Gershman
Heavy Metals Implications To Sediment Microbiome And Coral Response To Arsenic Dosing, Dimitrios G. Giarikos, Amy Hirons, Jose V. Lopez, Abigail Renegar, Jason Gershman
SECLER Data
No abstract provided.
Therapy-Related Chronic Myelomonocytic Leukemia Does Not Have The High-Risk Features Of A Therapy-Related Neoplasm, Alex Bataller, Georgina Gener-Ricos, Emmanuel Almanza-Huante, Kelly S Chien, Samuel Urrutia, Juan Jose Rodriguez-Sevilla, Koji Sasaki, Koichi Takahashi, Courtney D Dinardo, Farhad Ravandi, Gautam Borthakur, Tapan M Kadia, Rashmi Kanagal-Shamanna, Hagop M Kantarjian, Guillermo Garcia-Manero, Guillermo Montalban-Bravo
Therapy-Related Chronic Myelomonocytic Leukemia Does Not Have The High-Risk Features Of A Therapy-Related Neoplasm, Alex Bataller, Georgina Gener-Ricos, Emmanuel Almanza-Huante, Kelly S Chien, Samuel Urrutia, Juan Jose Rodriguez-Sevilla, Koji Sasaki, Koichi Takahashi, Courtney D Dinardo, Farhad Ravandi, Gautam Borthakur, Tapan M Kadia, Rashmi Kanagal-Shamanna, Hagop M Kantarjian, Guillermo Garcia-Manero, Guillermo Montalban-Bravo
Faculty, Staff and Student Publications
Therapy-related myeloid neoplasms (t-MNs) arise after exposure to cytotoxic therapies and are associated with high-risk genetic features and poor outcomes. We analyzed a cohort of patients with therapy-related chronic myelomonocytic leukemia (tCMML; n = 71) and compared its features to that of de novo CMML (dnCMML; n = 461). Median time from cytotoxic therapy to tCMML diagnosis was 6.5 years. Compared with dnCMML, chromosome-7 abnormalities (4% vs 13%; P = .005) but not complex karyotype (3% vs 7%; P = .15), were more frequent in tCMML. tCMML was characterized by higher TP53 mutation frequency (4% vs 12%; P = .04) …
Collaborative Modeling To Compare Different Breast Cancer Screening Strategies: A Decision Analysis For The Us Preventive Services Task Force, Amy Trentham-Dietz, Christina Hunter Chapman, Jinani Jayasekera, Kathryn P Lowry, Brandy M Heckman-Stoddard, Jennifer L Caswell-Jin, Ying Lu, Hui Huang, Sarah Stein, Liyang Sun, Eugenio J Gil Quessep, Yuanliang Yang, Yifan Lu, Juhee Song, Diego F Muñoz, Yisheng Li, Allison W Kurian, Karla Kerlikowske, Ellen S O'Meara, Brian L Sprague, Anna N A Tosteson, Eric J Feuer, Donald Berry, Sylvia K Plevritis, Xuelin Huang, Harry J De Koning, Nicolien T Van Ravesteyn, Sandra J Lee, Oguzhan Alagoz, Clyde B Schechter, Natasha K Stout, Diana L Miglioretti, Jeanne S Mandelblatt
Collaborative Modeling To Compare Different Breast Cancer Screening Strategies: A Decision Analysis For The Us Preventive Services Task Force, Amy Trentham-Dietz, Christina Hunter Chapman, Jinani Jayasekera, Kathryn P Lowry, Brandy M Heckman-Stoddard, Jennifer L Caswell-Jin, Ying Lu, Hui Huang, Sarah Stein, Liyang Sun, Eugenio J Gil Quessep, Yuanliang Yang, Yifan Lu, Juhee Song, Diego F Muñoz, Yisheng Li, Allison W Kurian, Karla Kerlikowske, Ellen S O'Meara, Brian L Sprague, Anna N A Tosteson, Eric J Feuer, Donald Berry, Sylvia K Plevritis, Xuelin Huang, Harry J De Koning, Nicolien T Van Ravesteyn, Sandra J Lee, Oguzhan Alagoz, Clyde B Schechter, Natasha K Stout, Diana L Miglioretti, Jeanne S Mandelblatt
Faculty, Staff and Student Publications
IMPORTANCE: The effects of breast cancer incidence changes and advances in screening and treatment on outcomes of different screening strategies are not well known.
OBJECTIVE: To estimate outcomes of various mammography screening strategies.
DESIGN, SETTING, AND POPULATION: Comparison of outcomes using 6 Cancer Intervention and Surveillance Modeling Network (CISNET) models and national data on breast cancer incidence, mammography performance, treatment effects, and other-cause mortality in US women without previous cancer diagnoses.
EXPOSURES: Thirty-six screening strategies with varying start ages (40, 45, 50 years) and stop ages (74, 79 years) with digital mammography or digital breast tomosynthesis (DBT) annually, biennially, or …
Role Of Ethanolamine Utilization And Bacterial Microcompartment Formation In Listeria Monocytogenes Intracellular Infection, Ayan Chatterjee, Karan Gautam Kaval, Danielle A Garsin
Role Of Ethanolamine Utilization And Bacterial Microcompartment Formation In Listeria Monocytogenes Intracellular Infection, Ayan Chatterjee, Karan Gautam Kaval, Danielle A Garsin
Faculty, Staff and Student Publications
Ethanolamine (EA) affects the colonization and pathogenicity of certain human bacterial pathogens in the gastrointestinal tract. However, EA can also affect the intracellular survival and replication of host cell invasive bacteria such as Listeria monocytogenes (LMO) and Salmonella enterica serovar Typhimurium (S. Typhimurium). The EA utilization (eut) genes can be categorized as regulatory, enzymatic, or structural, and previous work in LMO showed that loss of genes encoding functions for the enzymatic breakdown of EA inhibited LMO intracellular replication. In this work, we sought to further characterize the role of EA utilization during LMO infection of host …
Slow Proliferation Of Bap1-Deficient Uveal Melanoma Cells Is Associated With Reduced S6 Signaling And Resistance To Nutrient Stress, Vivian Chua, Melisa Lopez-Anton, Mizue Terai, Ryota Tanaka, Usman Baqai, Jelan I Haj, Isabella Trachtenberg, Kristine Luo, Rohith Tudi, Angela Jeon, Anna Han, Inna Chervoneva, Michael A Davies, Julio A Aguirre-Ghiso, Takami Sato, Andrew E Aplin
Slow Proliferation Of Bap1-Deficient Uveal Melanoma Cells Is Associated With Reduced S6 Signaling And Resistance To Nutrient Stress, Vivian Chua, Melisa Lopez-Anton, Mizue Terai, Ryota Tanaka, Usman Baqai, Jelan I Haj, Isabella Trachtenberg, Kristine Luo, Rohith Tudi, Angela Jeon, Anna Han, Inna Chervoneva, Michael A Davies, Julio A Aguirre-Ghiso, Takami Sato, Andrew E Aplin
Faculty, Staff and Student Publications
Uveal melanoma (UM) is the deadliest form of eye cancer in adults. Inactivating mutations and/or loss of expression of the gene encoding BRCA1-associated protein 1 (BAP1) in UM tumors are associated with an increased risk of metastasis. To investigate the mechanisms underlying this risk, we explored the functional consequences of BAP1 deficiency. UM cell lines expressing mutant BAP1 grew more slowly than those expressing wild-type BAP1 in culture and in vivo. The ability of BAP1 reconstitution to restore cell proliferation in BAP1-deficient cells required its deubiquitylase activity. Proteomic analysis showed that BAP1-deficient cells had decreased phosphorylation of ribosomal S6 and …
Fluorescent Carbon Nanodot-Based Rapid Cell Nucleus Staining And Application For Diagnosis, Daiming Zhong, Huamin Yuan, Qiuyan Tian, Gongping Deng, Yanhong Ouyang, Yi Chen, Yang Wang, Zhiqin Yuan
Fluorescent Carbon Nanodot-Based Rapid Cell Nucleus Staining And Application For Diagnosis, Daiming Zhong, Huamin Yuan, Qiuyan Tian, Gongping Deng, Yanhong Ouyang, Yi Chen, Yang Wang, Zhiqin Yuan
Journal of Food and Drug Analysis
Cell nucleus status decides the activities of corresponding cells, making its rapid and effective staining important for revealing the actual condition of biological environment in life science and related fields. In this study, fast staining of cell nucleus is realized by fluorescent carbon nanodots (CDs). The staining mechanism is due to the positively charged CD surface-induced cell membrane penetration, which facilitates the CD-nucleus binding via electrostatic attraction. The size of cell nucleus is easily measured with fluorescence imaging technique. In addition, the CD-based cell nucleus stain is applied for discriminating the normal and cancer cells by determining the cell-to-nucleus ratio …
Effects Of Ibuprofen In The Zdf Rat Model Of Type 2 Diabetes, Alexander Gosslau, Unsal Ozdogru, Emmanuel Zachariah, Shiming Li, Chi-Tang Ho
Effects Of Ibuprofen In The Zdf Rat Model Of Type 2 Diabetes, Alexander Gosslau, Unsal Ozdogru, Emmanuel Zachariah, Shiming Li, Chi-Tang Ho
Journal of Food and Drug Analysis
We aimed to investigate the therapeutic potential of ibuprofen against type 2 diabetes (T2D) using obese Zucker diabetic fatty (ZDF) rats as type 2 diabetes model. ZDF rats were hyperglycemic, dyslipidemic and expressed pro-inflammatory markers in contrast to lean controls, thus reflecting the relationship between obesity and chronic inflammation promoting T2D. Chronic treatment with ibuprofen (2-(4-Isobutylphenyl)propanoic acid) was used to study the impact on pathological T2D conditions as compared to metformin (1,1-dimethylbiguanide) treated ZDF as well as lean controls. Ibuprofen decreased A1c but induced a high insulin release with improved glucose tolerance only after early time points (i.g., 15 and …
Citrus Depressa Peel Extract Act As A Prebiotic To Reduce Lipid Accumulation And Modulate Gut Microbiota In Obese Mice, Zheng-Yuan Su, Jie-An Liao, Ching-Ting Lin, Guor-Jien Wei, Yen-Chen Tung
Citrus Depressa Peel Extract Act As A Prebiotic To Reduce Lipid Accumulation And Modulate Gut Microbiota In Obese Mice, Zheng-Yuan Su, Jie-An Liao, Ching-Ting Lin, Guor-Jien Wei, Yen-Chen Tung
Journal of Food and Drug Analysis
Citrus peels contain abundant polyphenols, particularly flavonoids, and have been shown to exert lipid accumulation decreasing ability. In this study, Citrus depressa peel applied to oven drying and extracted with ethanol extract as CDEE to analyze its flavonoids compositions and investigated its effects on a high-fat diet (HFD)-induced obese mice model. CDEE contained several flavonoids such as hesperidin, sinesentin, nobiletin, tangeretin, 5-demethylnobiletin, and 5-demethyltangeretin. The mice fed an HFD, and administration of 2% CDEE to could decrease weight gain, abdominal fat weight, inguinal fat weight, and the adipocyte size, and CDEE also reduced serum total cholesterol (TCHO), triacylglycerol (TG) compared …
Antityrosinase Activity And Lc-Ms/Ms Analysis Of Optimized Ultrasound-Assisted Condition Extracts And Fractions From Strawberry Tree (Arbutus Unedo L.), Serdar Demir, Halil Koyu, Mustafa Abdullah Yilmaz, Abbas Tarhan, Sura Baykan Ozturk
Antityrosinase Activity And Lc-Ms/Ms Analysis Of Optimized Ultrasound-Assisted Condition Extracts And Fractions From Strawberry Tree (Arbutus Unedo L.), Serdar Demir, Halil Koyu, Mustafa Abdullah Yilmaz, Abbas Tarhan, Sura Baykan Ozturk
Journal of Food and Drug Analysis
Investigation of utilization possibilities of natural sources has been an important area for research. Tyrosinase inhibitory activity plays a key role in food and medicine industry. Strawberry tree (Arbutus unedo), a widely distributed plant among Mediterranean countries, possess fruits and leaves with rich bioactive phytochemicals, especially polyphenolic compounds. In this study, we aimed to investigate the antityrosinase activity of the fruit and leaf extracts of the plant, and to determine the phenolic compounds that contribute to the antityrosinase activity. In this regard, we evaluated the effect of solvent composition on the extraction of phenolic compounds from A. unedo …
Detection Of Aflatoxin B1 In Chili Powder Using Attenuated Total Reflectance–Fourier Transform Infrared Spectroscopy, Thin Thin Sein, Urairat Mongmonsin, Patutong Chatchawal, Molin Wongwattanakul, Oranee Srichaiyapol, Rungrueang Pattanakul, Patcharaporn Tippayawat
Detection Of Aflatoxin B1 In Chili Powder Using Attenuated Total Reflectance–Fourier Transform Infrared Spectroscopy, Thin Thin Sein, Urairat Mongmonsin, Patutong Chatchawal, Molin Wongwattanakul, Oranee Srichaiyapol, Rungrueang Pattanakul, Patcharaporn Tippayawat
Journal of Food and Drug Analysis
Aflatoxin B1, a major global food safety concern, is produced by toxigenic fungi during crop growing, drying, and storage, and shows increasing annual prevalence. This study aimed to detect aflatoxin B1 in chili samples using ATR–FTIR coupled with machine learning algorithms. We found that 83.6% of the chili powder samples were contaminated with Aspergillus and Penicillium species, with aflatoxin B1 levels ranging from 7.63 to 44.32 µg/kg. ATR–FTIR spectroscopy in the fingerprint region (1800−400 cm-1) showed peak intensity variation in the bands at 1587, 1393, and 1038 cm-1, which are mostly related …
Comparative Bioactivity Assessment Of Bixin Pigment And Associated Phytochemicals Extracted From Annatto Seeds Using Conventional And Green Solvents, Sonakshi Puri, Sumit Kumar Mandal, Harshit Jain, Pankaj Kumar Sharma, Perinkulam Ravi Deepa
Comparative Bioactivity Assessment Of Bixin Pigment And Associated Phytochemicals Extracted From Annatto Seeds Using Conventional And Green Solvents, Sonakshi Puri, Sumit Kumar Mandal, Harshit Jain, Pankaj Kumar Sharma, Perinkulam Ravi Deepa
Journal of Food and Drug Analysis
Nutraceuticals, that include food ingredients and bioactives from natural products, confer physiological health benefits and protection against chronic diseases. Annatto is a tropical shrub grown in Central and South America and parts of India. Its seeds are rich in the edible carotenoid-derived apocarotenoid pigment, bixin, which is used as a natural colorant in food, textiles, and cosmetics, and is now gaining attention for its potential health-promoting attributes. Here, we compared a green solvent (ethyl lactate) based extraction of bixin and associated metabolites in annatto seeds (crushed and seed coat) with two other conventional solvents (acetone and acid-base). Bixin was characterized …
Chemical Constituents From A Marine Medicinal Brown Alga-Derived Xylaria Acuta Sc1019, Hsiao-Yang Hsi, Shih-Wei Wang, George Hsiao, Li-Kwan Chang, Yuan-Chung Cheng, Shu-Jung Huang, Yi-Shan Lu, Tzong-Huei Lee
Chemical Constituents From A Marine Medicinal Brown Alga-Derived Xylaria Acuta Sc1019, Hsiao-Yang Hsi, Shih-Wei Wang, George Hsiao, Li-Kwan Chang, Yuan-Chung Cheng, Shu-Jung Huang, Yi-Shan Lu, Tzong-Huei Lee
Journal of Food and Drug Analysis
In this study, a marine medicinal brown alga Sargassum cristaefolium-derived fungal strain Xylaria acuta SC1019 was isolated and identified. Column chromatography of the extracts from liquid- and solid-fermented products of the fungal strain was carried out, and led to the isolation of twenty-one compounds. Their structures were characterized by spectroscopic analysis, and the absolute configurations were further established by single X-ray diffraction analysis or modified Mosher’s method as nine previously undescribed compounds, namely xylarilactones A–C (1–3), ent-gedebic acid 8-O-α-D-glucopyranoside (4), 5R-hydroxylmethylmellein 11-O-α-D-glucopyranoside (5), ent …
The Role And Mechanism Of Cinnamaldehyde In Cancer, Jiahua Peng, Xin Song, Wenbin Yu, Yuhan Pan, Yufei Zhang, Hui Jian, Bin He
The Role And Mechanism Of Cinnamaldehyde In Cancer, Jiahua Peng, Xin Song, Wenbin Yu, Yuhan Pan, Yufei Zhang, Hui Jian, Bin He
Journal of Food and Drug Analysis
As cancer continues to rise globally, there is growing interest in discovering novel methods for prevention and treatment. Due to the limitations of traditional cancer therapies, there has been a growing emphasis on investigating herbal remedies and exploring their potential synergistic effects when combined with chemotherapy drugs. Cinnamaldehyde, derived from cinnamon, has gained significant attention for its potential role in cancer prevention and treatment. Extensive research has demonstrated that cinnamaldehyde exhibits promising anticancer properties by modulating various cellular processes involved in tumor growth and progression. However, challenges and unanswered questions remain regarding the precise mechanisms for its effective use as …
Trends And Current Food Safety Regulations And Policies For Functional Foods And Beverages Containing Botanicals, Jarunee Intrasook, Takuji W. Tsusaka, Anil Kumar Anal
Trends And Current Food Safety Regulations And Policies For Functional Foods And Beverages Containing Botanicals, Jarunee Intrasook, Takuji W. Tsusaka, Anil Kumar Anal
Journal of Food and Drug Analysis
Globally, the demand for functional foods and beverages has significantly increased due to socioeconomic changes, particularly in health consciousness to enhance their functionality. Functional ingredients derived from botanicals are widely used because of their phytochemical properties with health benefits. This study aims to (1) review the capabilities and challenges of botanical addition in functional foods, (2) review current policies and regulations for functional foods containing botanicals in the European Union (EU), Canada, Japan, the Republic of Korea, and Thailand, and (3) provide recommendations on effective food safety control measures for better consumer trust and trade facilitation. This critical review was …
Identifying The Lead Molecule From Carica Papaya Using Computer-Aided Drug Design Technique Against Streptococcus Pneumoniae, Prajwal Bhanu, Sushma Pradeep, Pruthvish Reddy, Prashanth Vishwanath, Sumanth R M, Girish M S, Bhargav Shreevatsa, Anisha S. Jain, Chandan Dharmashekara, Shiva Prasad Kollur, Sai Chakith Mr, Ashwini P, Chandan Shivamallu, Chandrashekar Srinivasa
Identifying The Lead Molecule From Carica Papaya Using Computer-Aided Drug Design Technique Against Streptococcus Pneumoniae, Prajwal Bhanu, Sushma Pradeep, Pruthvish Reddy, Prashanth Vishwanath, Sumanth R M, Girish M S, Bhargav Shreevatsa, Anisha S. Jain, Chandan Dharmashekara, Shiva Prasad Kollur, Sai Chakith Mr, Ashwini P, Chandan Shivamallu, Chandrashekar Srinivasa
International Journal of Health and Allied Sciences
Streptococcus pneumoniae, a gram-positive cocci bacterium found in the oral cavity and nasopharynx of humans causes acute respiratory infections and pneumonia progression. This study aims to identify highly susceptible, antimicrobial, therapeutic phytochemicals from the leaf extract of the medicinal Carica papaya plant which acts as antibiotic by inhibiting the mechanism of action of Streptococcus species. Using an in silico molecular docking approach, the 3D ligand structures of the screened phytoconstituents of Carica papaya are made to dock with the active pocket of targeted proteins i.e. Cytidine deaminase, 5' methylthionadenosine/S-Adenosylhomocysteine nucleosidase and phosphomevalonate Kinase in Complex with Phosphomevalonate and AMPPNP …
Empowerher: A Pilot Study To Increase Physical Activity And Strength Through Powerbuilding, Aspen E. Streetman, Murry T. Streetman, Halle N. Brin, Emily L. Mailey, Katie M. Heinrich
Empowerher: A Pilot Study To Increase Physical Activity And Strength Through Powerbuilding, Aspen E. Streetman, Murry T. Streetman, Halle N. Brin, Emily L. Mailey, Katie M. Heinrich
International Journal of Exercise Science
International Journal of Exercise Science 17(8): 750-767, 2024. Engaging in empowering exercise develops movement competency (MC) and strength and supports physical health, mental well-being, and quality of life. Powerbuilding combines powerlifting and bodybuilding to increase physical activity (PA), MC, and strength. To our knowledge, powerbuilding has not been explored as an exercise intervention. This pilot study investigated the impact of an eight-week powerbuilding intervention on women’s PA, MC, strength, and empowerment. Eighteen women aged 25.1±9.8 with no powerbuilding experience participated in the intervention, meeting three times weekly for one hour. PA and MC were assessed pre- and post-intervention. Three-repetition maximum …
The 2024 International Journal Of Exercise Science Position Stand On Inclusion, James W. Navalta, Dustin W. Davis, Jafra Thomas, Matthew J. Garver, Shannon Siegel, Joel D. Reece, Jill M. Maples
The 2024 International Journal Of Exercise Science Position Stand On Inclusion, James W. Navalta, Dustin W. Davis, Jafra Thomas, Matthew J. Garver, Shannon Siegel, Joel D. Reece, Jill M. Maples
International Journal of Exercise Science
International Journal of Exercise Science 17(8): 730-749, 2024. The International Journal of Exercise Science (IJES) Working Group for Opportunity, Representation, and Diverse Perspectives was tasked with developing a position stand to provide guidance in critical areas of inclusion. We present to authors, reviewers, and all readership IJES ideals to utilize in practice. Key points are presented, followed by a deeper look with greater explanation into the areas of inclusive language, diversity and inclusion in research, and accessibility. The same approach is presented for the areas of age, disability status, gender identity and sexual orientation, race, and ethnicity with attention to …
Stand Diversity Increases Pine Resistance And Resilience To Compound Disturbance, Sara J. Germain, James A. Lutz
Stand Diversity Increases Pine Resistance And Resilience To Compound Disturbance, Sara J. Germain, James A. Lutz
Wildland Resources Faculty Publications
Background
Drought, fire, and insects are increasing mortality of pine species throughout the northern temperate zone as climate change progresses. Tree survival may be enhanced by forest diversity, with growth rates often higher in mixed stands, but whether tree defenses are likewise aided remains in question. We tested how forest diversity-productivity patterns relate to growth and defense over three centuries of climate change, competition, wildfire, and bark beetle attack. We used detailed census data from a fully mapped 25.6-ha forest dynamics plot in California, USA to conduct a spatially explicit, dendroecological assessment of large-diameter Pinus lambertiana survival following fire reintroduction. …