Life Sciences Commons^™

Machine Learning Vegetation Filtering Of Coastal Cliff And Bluff Point Clouds, Phillipe A. Wernette

Michigan Tech Publications

Coastal cliffs erode in response to short- and long-term environmental changes, but predicting these changes continues to be a challenge. In addition to a chronic lack of data on the cliff face, vegetation presence and growth can bias our erosion measurements and limit our ability to detect geomorphic erosion by obscuring the cliff face. This paper builds on past research segmenting vegetation in three-band red, green, blue (RGB) imagery and presents two approaches to segmenting and filtering vegetation from the bare cliff face in dense point clouds constructed from RGB images and structure-from-motion (SfM) software. Vegetation indices were computed from …

Assessment Of Georgia’S Royal Catchfly (Silene Regia) Along A Forest-Edge Gradient In A Remnant Prairie Community, Megan Brooks

Master's Theses

Royal catchfly (Silene regia) is a perennial prairie forb known to grow in rocky, alkaline soils within tallgrass prairies of the eastern United States. S. regia is recorded from twelve states, including Georgia, and is now confined to fragmented habitats due to the loss of 95% of its natural environment. The species is now listed as critically imperiled in the state of Georgia. Attempts at reintroduction via outplanting have only shown limited success, necessitating more research on the environmental conditions in which this plant survives in its southern-most distribution. This study investigated the local ecological factors influencing the …

Effect Of Plumbagin On Chemo-Resistant Metastatic Retinoblastoma, John J. Soto

Theses and Dissertations

Retinoblastoma, which is an ocular malignancy, usually results in poor prognoses in pediatric patients worldwide. Retinoblastoma in some events, can develop metastatic phenotypes which can lead to secondary tumor formation, furthering deleterious patient outcomes. It is of paramount importance to identify and research potent novel compounds that can be used to increase the likelihood of remission. Plumbagin (PLB) is a plant-derived, neuroprotective agent, which exhibits significant anticancer activities during in vitro study. PLB has been shown to have a high therapeutic efficacy against chemoresistant sublines as well as their normal counterparts. We attempted to show that the chemoresistant ABCC1 could …

Perspectives On Computational Modeling Of Biological Systems And The Significance Of The Sysmod Community, Bhanwar Lal Puniya, Meghna Verma, Chiara Damiani, Shaimaa Bakr, Andreas Dräger

Department of Biochemistry: Faculty Publications

Motivation: In recent years, applying computational modeling to systems biology has caused a substantial surge in both discovery and practical applications and a significant shift in our understanding of the complexity inherent in biological systems.

Results: In this perspective article, we briefly overview computational modeling in biology, highlighting recent advancements such as multiscale modeling due to the omics revolution, single-cell technology, and integration of artificial intelligence and machine learning approaches. We also discuss the primary challenges faced: integration, standardization, model complexity, scalability, and interdisciplinary collaboration. Lastly, we highlight the contribution made by the Computational Modeling of Biological Systems …

Assessing The Impact Of Storage Conditions On Rna From Human Saliva And Its Application To The Identification Of Mrna Biomarkers For Asthma, Poorna Manasa Bhamidimarri, David Fuentes, Laila Salameh, Bassam Mahboub, Rifat Hamoudi

Faculty, Staff and Student Publications

Introduction: Human saliva was used to develop non-invasive liquid biopsy biomarkers to establish saliva as an alternate to blood and plasma in translational research. The present study focused on understanding the impact of sample storage conditions on the extraction of RNA from saliva and the RNA yield, to be applied in clinical diagnosis. In this study, genes related to asthma were used to test the method developed.

Methods: Salivary RNA was extracted from three subjects using the Qiazol® based method and quantified by both spectrophotometric (NanoDrop) and fluorometric (Qubit®) methods. RNA integrity was measured using a bioanalyzer. Quantitative PCR was …

Immunotherapy In Locally Advanced Cervical Cancer: Integrating Keynote-A18 Into Management Strategies, Jeffrey A How, Amir A Jazaeri

Faculty, Staff and Student Publications

In locally advanced cervical cancer (LACC), the benefit of PD-1 blockade was unknown. In KEYNOTE-A18, Lorusso et al.1 compared the efficacy and safety of adding pembrolizumab to chemoradiation in LACC and demonstrated favorable outcomes. Given multiple approved indications of pembrolizumab in cervical cancer, strategies for optimal integration into management will be needed to maximize overall survival.

Persistent Gram-Negative Bloodstream Infection Increases The Risk Of Recurrent Bloodstream Infection With The Same Species, Paa Kwesi Ankrah, Andrew Bock, Felicia Ruffin, Blake M Hanson, Cesar A Arias, Joshua Parsons, Joshua T Thaden

Faculty, Staff and Student Publications

The association between persistent gram-negative bloodstream infection (GN-BSI), or ongoing positive cultures, and recurrent GN-BSI has not been investigated. Among 992 adults, persistent GN-BSI was associated with increased recurrent GN-BSI with the same bacterial species and strain (6% vs 2%; P = .04). Persistent GN-BSI may be a marker of complicated infection.

Current And Future Environmental Suitability For Bats Hosting Potential Zoonotic Pathogens In Rural Kenya, Ruut Uusitalo, Reilly T. Jackson, Tamika J. Lunn, Essi M. Kohonen, Joseph G. Ogala, Paul W. Wabala, Tarja A. Sironen, Kristian M. Forbes

Biological Sciences Faculty Publications and Presentations

Synanthropic bats live in close proximity to humans and domestic animals, creating opportunities for potential pathogen spillover. We explored environmental correlates of occurrence for a widely distributed synanthropic African bat, Mops pumilus—a species associated with potential zoonotic viruses—and estimated current and future environmental suitability in the Taita Hills region and surrounding plains in Taita–Taveta County in southeast Kenya. To project future environmental suitability, we used four Coupled Model Intercomparison Project Phase 6 general circulation models that capture temperature and precipitation changes for East Africa. The models were parameterized with empirical capture data of M. pumilus collected …

Heterogeneous Resources In Infrastructures Of The Edge Network Paradigm: A Comprehensive Review, Qusay S. Alsaffar, Leila Ben Ayed

Karbala International Journal of Modern Science

The late 1990s saw the rise of the edge computing network paradigm, as well as an increase in the number of IoT de-vices. This concept is viewed as a link between cloud servers and end-devices, bringing processing and storage re-sources closer to clients. As a result of its low latency and high performance, researchers and developers have expressed interest in it. However, this paradigm confronts a number of obstacles and restrictions, including restricted and hetero-geneous resources at network edges. In this paper, we provide a detailed review of heterogeneous resources in edge network infrastructures using a three-dimensional method. These three …

Puberty Classifications In Beef Heifers Are Moderately To Highly Heritable And Associated With Candidate Genes Related To Cyclicity And Timing Of Puberty, Melanie K. Hess, Anteneh Mersha, Sadie S. Ference, Sarah R. Nafziger, Jessica A. Keane, Anna M. Fuller, Scott G. Kurz, Courtney M. Sutton, Matthew L. Spangler, Jessica Lynn Petersen, Andrea S. Cupp

Department of Animal Science: Faculty Publications

Introduction: Pubertal attainment is critical to reproductive longevity in heifers. Previously, four heifer pubertal classifications were identified according to attainment of blood plasma progesterone concentrations > 1 ng/ml: 1) Early; 2) Typical; 3) Start-Stop; and 4) Non-Cycling. Early and Typical heifers initiated and maintained cyclicity, Start-Stop started and then stopped cyclicity and Non- Cycling never initiated cyclicity. Start-Stop heifers segregated into Start-Stop- Discontinuous (SSD) or Start-Stop-Start (SSS), with SSD having similar phenotypes to Non-Cycling and SSS to Typical heifers. We hypothesized that these pubertal classifications are heritable, and loci associated with pubertal classifications could be identified by genome wide association …

Neuroinflammation And Gut Barrier Function Post Traumatic Brain Injury, Anne Sullivan

Master's Theses

Traumatic Brain Injury (TBI) is a major cause of morbidity and mortality that afflicts millions of people in the United States annually. TBI mice had significantly increased expression of the pro-inflammatory cytokines and decreased expression of tight junction proteins CLDN5, CLDN12, and OCLD in brain lesion tissue. TBI mice exhibited a significant accumulation of FITC in the middle and distal part of the small intestine compared to sham mice. TBI mice exhibited an increase in pathogenic bacteria Enterobacteriaceae and a decrease in beneficial bacteria lactobacillus. TBI mice exhibited a trend toward an increase in permeability compared to no treatment. These …

Biological Lags And Market Dynamics In Vertically Coordinated Food Supply Chains: Hpai Impacts On U.S. Egg Prices, James L. Mitchell, Jada M. Thompson, Trey Malone

Department of Agricultural Economics Faculty Publications

It is well known that livestock production involves long biological lags. Failure to account for these biological lags can result in the misspecification of supply chain relationships and adjustments to market shocks, which can have significant implications for policy decisions. An example is the 2022 Highly Pathogenic Avian Influenza (HPAI) event that caused high mortality rates in domestic poultry supply chains and reduced egg production. We use the 2022–2023 HPAI event to highlight the implications of misspecification of disease dynamics in agri-food systems. Specifically, we examine the impact of HPAI on U.S. egg prices in 2022–2023. To do this, we …

Ancient Nitrogenases Are Atp Dependent, Derek F. Harris, Holly R. Rucker, Amanda K. Garcia, Zhi-Yong Yang, Scott D. Chang, Hannah Feinsilber, Betül Kaçar, Lance C. Seefeldt

Chemistry and Biochemistry Faculty Publications

Life depends on a conserved set of chemical energy currencies that are relics of early biochemistry. One of these is ATP, a molecule that, when paired with a divalent metal ion such as Mg²⁺, can be hydrolyzed to support numerous cellular and molecular processes. Despite its centrality to extant biochemistry, it is unclear whether ATP supported the function of ancient enzymes. We investigate the evolutionary necessity of ATP by experimentally reconstructing an ancestral variant of the N₂-reducing enzyme nitrogenase. The Proterozoic ancestor is predicted to be ~540–2,300 million years old, post-dating the Great Oxidation Event. Growth …

Incorporating Oxygen Isotopes Of Oxidized Reactive Nitrogen In The Regional Atmospheric Chemistry Mechanism, Version 2 (Icoin-Racm2), Wendell W. Walter, Masayuki Takeuchi, Nga L. Ng, Meredith G. Hastings

Faculty Publications

The oxygen isotope anomaly (Δ¹⁷O = δ¹⁷O − 0.52 × δ¹⁸O > 0) has proven to be a robust tool for probing photochemical cycling and atmospheric formation pathways of oxidized reactive nitrogen (NO_y). Several studies have developed modeling techniques to implicitly model Δ¹⁷O of NO_y molecules based on numerous assumptions that may not always be valid. Thus, these models may be oversimplified and limit our ability to compare model Δ¹⁷O values of NO_y with observations. In this work, we introduce a novel method for explicitly tracking Δ …

Pollination And Seed Production Of Lavandula Angustifolia Mill. (Lamiaceae), Sam S. Ingram, Tyler M. Wilson, Joseph S. Wilson, Emma A. Ziebarth, Makenna C. Johnson, Jacob G. Young, Richard E. Carlson

Biology Faculty Publications

Lavandula angustifolia Mill., lavender, is an aromatic plant in the Lamiaceae family. Lavender is an important economic plant that is cultivated throughout the world. Previous studies have shown that the primary pollinators of lavender in Europe and North Africa are bee species, specifically Bombus spp. However, similar studies have not been previously performed in North America. The current study, on cultivated population lavender (grown from seed) in Utah (USA), found a diverse community of bees visiting lavender over a 4-week sequential and successive blooming period. The observed and identified bees were distinguished across 8 genera and 12 species, of which …

Ikzf1 And Ubr4 Gene Variants Drive Autoimmunity And Th2 Polarization In Igg4-Related Disease, Qingxiang Liu, Yanyan Zheng, Ines Sturmlechner, Abhinav Jain, Maryam Own, Huimin Zhang, Karen Cerosaletti, Jane H Buckner, Kenneth J Warrington, Matthew J Koster, Cornelia M Weyand, Jörg J Goronzy

Faculty, Staff and Student Publications

IgG4-related disease (IgG4-RD) is a systemic immune-mediated fibroinflammatory disease whose pathomechanisms remain poorly understood. Here, we identified gene variants in familial IgG4-RD and determined their functional consequences. All 3 affected members of the family shared variants of the transcription factor IKAROS, encoded by IKZF1, and the E3 ubiquitin ligase UBR4. The IKAROS variant increased binding to the FYN promoter, resulting in higher transcription of FYN in T cells. The UBR4 variant prevented the lysosomal degradation of the phosphatase CD45. In the presence of elevated FYN, CD45 functioned as a positive regulatory loop, lowering the threshold for T cell activation. Consequently, …

Supporting Ontario Public Health Units To Address Adverse Childhood Experiences In Pandemic Recovery Planning: A Priority-Setting Exercise, Kimberly B Harding, Erica Di Ruggiero, Erick Gonzalez, Amanda Hicks, Daniel W Harrington

Faculty, Staff and Student Publications

BACKGROUND: Adverse childhood experiences (ACEs) are potentially traumatic exposures experienced during childhood, for example, neglect. There is growing evidence that the coronavirus disease 2019 (COVID-19) pandemic and related socioeconomic conditions contributed to an increased risk of ACEs. As public health programs/services are re-evaluated and restored following the state of emergency, it is important to plan using an ACEs-informed lens. The aim of this study was to identify and prioritize initiatives or activities that Public Health Ontario (PHO) could undertake to support Ontario public health units' work towards ACEs-informed pandemic recovery plans.

METHODS: The Child Health and Nutrition Research Initiative method …

Identifying Mage-A4-Positive Tumors For Tcr T Cell Therapies In Hla-A∗02-Eligible Patients, Tianjiao Wang, Jean-Marc Navenot, Stavros Rafail, Cynthia Kurtis, Mark Carroll, Sofie Van Rossom, Konstantinos Avraam, Robyn Broad, Karen Howe, Ashley Liddle, Amber Clayton, Ruoxi Wang, Laura Quinn, Joseph P Sanderson, Cheryl Mcalpine, Carly Carozza, Eric Pimpinella, Susan Hsu, Francine Brophy, Erica Elefant, Paige Bayer, Dennis Williams, Marcus O Butler, Jeffrey M Clarke, Justin F Gainor, Ramaswamy Govindan, Victor Moreno, Melissa Johnson, Janet Tu, David S Hong, George R Blumenschein

Faculty, Staff and Student Publications

T cell receptor (TCR) T cell therapies target tumor antigens in a human leukocyte antigen (HLA)-restricted manner. Biomarker-defined therapies require validation of assays suitable for determination of patient eligibility. For clinical trials evaluating TCR T cell therapies targeting melanoma-associated antigen A4 (MAGE-A4), screening in studies NCT02636855 and NCT04044768 assesses patient eligibility based on: (1) high-resolution HLA typing and (2) tumor MAGE-A4 testing via an immunohistochemical assay in HLA-eligible patients. The HLA/MAGE-A4 assays validation, biomarker data, and their relationship to covariates (demographics, cancer type, histopathology, tissue location) are reported here. HLA-A∗02 eligibility was 44.8% (2,959/6,606) in patients from 43 sites across …

Durable Objective Response To Lurbinectedin In Small Cell Bladder Cancer With Tp53 Mutation: A Molecular-Directed Strategy, Mohammad Jad Moussa, Jaanki Khandelwal, Nathaniel R Wilson, Sagar A Naik, Vivek Subbiah, Pavlos Msaouel, Omar Alhalabi

Faculty, Staff and Student Publications

Small cell bladder cancer (SCBC) is a rare and aggressive disease, often treated with platinum/etoposide-based chemotherapy. Key molecular drivers include the inactivation of onco-suppressor genes (TP53, RB1) and amplifications in proto-oncogenes (MYC). We report a patient with SCBC who achieved an objective and prolonged response to lurbinectedin, which has been approved for metastatic small cell lung cancer, after developing disease progression on cisplatin/etoposide and nivolumab/ipilimumab. A genomic analysis of a metastatic biopsy prior to lurbinectedin initiation revealed a TP53 mutation and amplification of the cell cycle regulators E2F3 and MYCL. A repeat biopsy following …

The Use Of Musculoskeletal Fitness Measures As Indicators Of Performance In Police Occupational Tasks, Elisa F.D. Canetti, Robin Marc Orr, William Brown, Ben Schram, Robert G. Lockie, J. Jay Dawes

International Journal of Exercise Science

International Journal of Exercise Science 17(4): 819-830, 2024. Fitness testing is employed by some law enforcement agencies to assure performance in occupational tasks. The aim of this study was to investigate associations between musculoskeletal fitness assessment scores and performance in police occupational tasks. Retrospective data from 106 law enforcement officers who completed five musculoskeletal fitness assessments (vertical jump (VJ), hand grip strength, leg back dynamometer, 1-minute push-ups and sit-ups) and three routine occupational tasks (1.22m fence jump (FJ), 8.5m victim drag (VD) with 101kg and a get-up (GU)) were collected. A standard multiple regression was performed to determine if the …

Normative Hamstrings And Quadriceps Isometric Strength Values And Hamstrings-Quadriceps Asymmetry In Healthy Collegiate Soccer And Basketball Players, Oluwatoyosi Owoeye, Davie Mulenga, Jemma Kim, Anthony Breitbach, Jamil Neme

International Journal of Exercise Science

International Journal of Exercise Science 17(4): 768-778, 2024. The objectives of this study were to report weight-normalized, sex- and sport-stratified normative values for hamstrings and quadriceps isometric strength in collegiate soccer and basketball players using a low-cost hand-held dynamometer and assess the prevalence of “substantial” hamstrings-quadriceps (H/Q) ratio strength imbalance (<0.6) among players. Ninety-four healthy collegiate male and female soccer and basketball players (age range: 18–24 years) were examined for baseline isometric hamstrings and quadriceps strength using a handheld isometric dynamometer with standardized and valid protocols. For soccer, the mean (95%CI) weight-normalized peak isometric strength values (considering dominant limbs) were 3.29 (2.90 to 3.64) N/kg (hamstrings) and 5.48 (4.96 to 6.00) N/kg (quadriceps) in male players and 2.62 (2.39 to 2.85) N/kg (hamstrings) and 4.55 (4.14 to 4.96) N/kg (quadriceps) in female players. For basketball, the mean (95% CI) peak strength values were 2.97 (2.72 to 3.21) N/kg (hamstrings) and 4.89 (4.44 to 5.33) N/kg (quadriceps) in male players and 2.48 (2.15 to 2.80) N/kg (hamstrings) and 4.21 (3.54 to 4.87) N/kg (quadriceps) in female players. The prevalence of substantial H/Q strength imbalance was 37% (95%CI: 24% to 52%) in soccer and 44% (95%CI: 29% to 60%) in basketball players. This study is first to provide normative values for peak isometric hamstrings and quadriceps strength using a low-cost hand-held dynamometer. The normative database from this study is valuable to coaches, sports medicine professionals, exercise scientists and other stakeholders to inform injury prevention, rehabilitation progression, return to play decisions and performance goals in collegiate soccer and basketball players.

Acute Effects Of Exercise At Different Temperatures On Clinical Symptoms And Nasal Blood Flow In Patient With Allergic Rhinitis: A Randomized Crossover Trial, Kanphatson Kerdkaew, Wannaporn Tongtako

International Journal of Exercise Science

International Journal of Exercise Science 17(3): 779-793, 2024. Allergic rhinitis (AR) affects the nose and is triggered by allergens. However, no research studies have analyzed the acute effect of aerobic exercise at different temperatures in AR patients. This study was to determine the acute effect of aerobic exercise at different temperatures on rhinitis symptoms and nasal blood flow (NBF) in AR patients. Fifteen AR patients aged 18–24 years were randomized in a crossover fashion into two protocols: 60 minutes of aerobic exercise at temperatures of 25 °C and 34 °C. The NBF, rhinitis symptoms, peak nasal inspiratory flow (PNIF), fractional …

Impact Of Latin Ballroom Dance Training On Gait Biomechanics, Anxiety, And Depression, Grace Hanks, Tyler Standifird, Barry Andelin

International Journal of Exercise Science

International Journal of Exercise Science 17(1): 794-809, 2024. The purpose of this study was to analyze the impact of Latin ballroom dance training on gait biomechanics, anxiety, and depression. There were twelve Latin ballroom dancers and twelve recreationally active non-dancers that participated in this research. For collecting data on gait biomechanics, participants walked on a pressure sensitive walkway system and force plates to collect information on foot and ground interactions. Reflective trackers were placed on the anterior part of their hips, knees, and ankles to measure frontal plane lower leg alignment during weight acceptance. A survey including the Generalized Anxiety …

اللجوء الإنساني في ضوء المواثيق الدولية, Shaker Salem Hamdan Kharabsheh, Omar Yasin Mahmoud Khdeirat, Solieman Hamdan Salem Kharabsheh

Journal of the Association of Arab Universities for Research in Higher Education مجلة اتحاد الجامعات العربية للبحوث في التعليم العالي

هدف المقال البحث في ماهية اللجوء الإنساني في ضوء المواثيق الدولية، من خلال بيان مفهوم اللجوء الإنساني، وتوضيح حقوق اللاجئ واجباته، واستعراض الإطار القانوني الدولي والإقليمي لحماية اللاجئين. ولتحقيق هذه الأهداف تمت الاستعانة بالمنهج الوصفي التحليلي، والمنهج القانوني. وقد توصلت الدراسة إلى أن اللجوء ظاهرة اجتماعية ذات بُعد إنساني قديمة قدم التاريخ، وإنه ولغاية إعداد هذه الدراسة لا يوجد تعريف واحد متفق عليه لحق اللجوء، حيث يتم النص على حق الفرد في طلب اللجوء دون وضع تعريف محدد له. ومن أهم الضمانات التي أقرتها المواثيق الدولية للاجيء عدم جواز طرده إلى البلد الذي يخشى فيه اضطهاده. وأن أبرز المعاهدات الدولية …

أثر تعاطي رب الأسرة للمخدرات على العنف ضد المرأة في العاصمة عمان دراسة حالة، المركز الوطني لتأهيل المدمنين في عمان (دراسة نوعية), Khader Khalil Al Rawajfa Mr., Khaled Tamim Professor

Journal of the Association of Arab Universities for Research in Higher Education مجلة اتحاد الجامعات العربية للبحوث في التعليم العالي

هدف المقال التعرف إلى أثر تعاطي رب الأسرة للمخدرات على العنف ضد المرأة في العاصمة عمان في المركز الوطني لتأهيل المدمنين في عمان، ولتحقيق أهداف الدراسة، تم استخدام المنهج النوعي، إذ تم إجراء مقابلات مع (6) نزلاء من أصل (9) نزلاء من أرباب الأسر المتعاطين للمخدرات والمعنفين للمرأة، وقد تم سحب العينة بطريقة عشوائية بسيطة. وأظهرت نتائج الدراسة بأن جميع النزلاء تعاطوا المخدرات قبل الزواج، وقد علمت زوجاتهم عن إدمانهم بعد زواجهم منهم، وجميع النزلاء المعنفين لزوجاتهم مارسوا العنف الجسدي واللفظي والنفسي ضدهن، وجميع عينة الدراسة أكدوا أن العنف كان موجهاً ضد الزوجة فقط. وأما بالنسبة لأسباب تعاطي رب الأسرة …

Enhanced Photocatalytic Degradation Of Rhodamine B Dye (Rhb), Fluorescein Dye (Flu), And Their Mixture Using Agi/Sno2 Photocatalyst, Saddam Alaskary

Chemical Engineering

AgI/SnO2 composites, synthesized via sol–gel method, emerge as highly efficient photocatalysts for degrading rhodamine B (RhB), fluorescein (Flu), and their mixtures, shifting photocatalytic activity into the visible spectrum. Characterized by XRD, FESEM, DRS, EDX, mapping, TEM, BET, and XPS, these nanocomposites, especially with 15% AgI, show a remarkable increase in photocatalytic efficiency for Flu, achieving a rate constant of 0.0189 min− 1 which is triple that of pure SnO2 at 0.0061 min− 1. The optimal degradation of Flu, RhB, and their mixture occurs with 0.1 g of the 15 wt% AgI/SnO2 composite. This enhancement is attributed to the Z-scheme mechanism …

From Australia To Nebraska: Researching Social Value, Marilyn R. Schlake, Cheryl A. Burkhart-Kriesel, Jean Ann Fischer, Michelle Krehbiel, Randy Saner

Cornhusker Economics

Globally, there is a growing body of research on social capital through the lens of social value, or how the social connections translate into actions with tangible outcomes impacting livelihoods and well-being. In the United States, social value is a relatively new perspective that will add to the social capital discussion.

The Polyaneuploid Cancer Cell State And Therapeutic Resistance: Eco-Evolutionary Dynamics In Structured Populations, Anuraag Bukkuri

USF Tampa Graduate Theses and Dissertations

In this dissertation, I develop and apply eco-evolutionary modeling techniques to understand how the polyaneuploid cancer cell (PACC) state, entered when aneuploid cells exit the cell cycle after S phase and undergo a whole genome duplication, contributes to therapeutic resistance. Since resistance remains one of the primary causes of treatment failure in cancer patients, it is critical to understand how such demographic state transitions allow for acclimatization of cancer cells to therapeutic stressors and how they interact with evolutionary processes to promote irreversible resistance.

In Chapters Two and Three, I lay the foundation for this work. In Chapter Two, I …

Net-Zero Transition In Ukraine: Implications For Sustainable Development Goal 7, Maksym Chepeliev, Oleksandr Diachuk, Roman Podolets, Andrii Semeniuk, Galyna Trypolska

Department of Agricultural Economics Faculty Publications

In this study, we use a TIMES-Ukraine energy system-wide model to explore net-zero transition in Ukraine. The assessment considers the potential implications of the ongoing war in the country and analyzes how the achievement of ambitious mitigation goals could impact the indicators related to the Sustainable Development Goal on energy, SDG7 (Ensure access to affordable, reliable, sustainable and modern energy). Results suggest that the net-zero transition would help improve several SDG7 indicators, including increased share of renewables in total final energy consumption, and increased energy affordability in the long run. However, in the medium run, increasing energy prices and rising …

Winter Gps Tagging Reveals Home Ranges During The Breeding Season For A Borealnesting Migrant Songbird, The Goldencrowned Sparrow, Autumn R. Iverson, Diana L. Humple, Renée L. Cromier, Thomas P. Hahn, Theadora A. Block, Daizaburo Shizuka, Bruce E. Lyon, Alexis S. Chaine, Emily J. Hudson, Elisha M. Hull

School of Biological Sciences: Faculty Publications

Determining space use for species is fundamental to understanding their ecology, and tracking animals can reveal insights into their spatial ecology on home ranges and territories. Recent technological advances have led to GPS-tracking devices light enough for birds as small as ~30 g, creating novel opportunities to remotely monitor fine-scale movements and space use for these smaller species. We tested whether miniaturized GPS tags can allow us to understand space use of migratory birds away from their capture sites and sought to understand both pre-breeding space use as well as territory and habitat use on the breeding grounds. We used …