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Articles 1801 - 1830 of 255677
Full-Text Articles in Life Sciences
Colostrum Management For Dairy Calves: Key Practices For Calf Health And Performance, Drew Swartz, Jacob Hadfield, Kalen Taylor, Maggi Mathews
Colostrum Management For Dairy Calves: Key Practices For Calf Health And Performance, Drew Swartz, Jacob Hadfield, Kalen Taylor, Maggi Mathews
All Current Publications
This fact sheet provides practical recommendations for dairy producers to improve colostrum management and support calf health and performance.
Vector-Borne Viral Diseases In Horses, Sunutcha Suntrarachun
Vector-Borne Viral Diseases In Horses, Sunutcha Suntrarachun
The Thai Journal of Veterinary Medicine
Vector-borne viral diseases are major threats to equine health worldwide. These infections are transmitted by arthropod vectors such as mosquitoes, biting midges, and horseflies, resulting in clinical manifestations ranging from mild febrile illness to severe neurological, respiratory, circulatory, or hematologic disorders with high mortality rates. Major equine vector-borne viral diseases include African horse sickness (AHS), equine infectious anemia (EIA), equine encephalomyelitis (Eastern: EEE, Western: WEE, and Venezuelan: VEE), West Nile virus (WNV), and Japanese encephalitis (JE). Each disease is caused by a distinct viral pathogen and transmitted by specific vectors that influence their epidemiology and geographic distribution. Transmission occurs through …
Reference Values For Intraocular Pressure In Collared Scops Owls (Otus Lettia) Measured Using Rebound Tonometry, Yun-Shan Chiu, Chau-Hwa Chie, Pin-Huan Yu, Chung-Tien Lin
Reference Values For Intraocular Pressure In Collared Scops Owls (Otus Lettia) Measured Using Rebound Tonometry, Yun-Shan Chiu, Chau-Hwa Chie, Pin-Huan Yu, Chung-Tien Lin
The Thai Journal of Veterinary Medicine
In this study, we aimed to establish species-specific reference values for intraocular pressure (IOP) in clinically healthy collared scops owls (Otus lettia) using rebound tonometry. Twelve free-living owls were included, and twentyfour eyes were examined. All owls were physically restrained in an upright position without sedation. Intraocular pressure was measured in both eyes using rebound tonometry (TONOVET; iCare Finland Oy, Vantaa, Finland) in d mode. No significant difference in IOP was observed between the right and left eyes. The mean IOP values were 10.42 ± 1.24 mmHg (median, 11 mmHg; range, 8–12 mmHg) in the right eye and 10.75 ± …
From The Edge To The Grounds Of “Sentientism”, David Degrazia
From The Edge To The Grounds Of “Sentientism”, David Degrazia
Animal Sentience
Birch’s book is a remarkable exploration of the nature of sentience, its moral salience, evidence for its presence, and how to arrive at humane policies regarding our treatment of human beings, animals, brain organoids, and AI systems of uncertain sentience. Although Birch endorses the view that sentience is of fundamental moral importance, he endeavors to remain neutral among reasonable moral views and work out how to navigate through uncertainty—both ethical and epistemological—to arrive at defensible policies. While making common cause with Birch’s project, my own recent book advances a developed case in favor of the “sentientism” Birch endorses.
Advancing Paradigm Of Quantitative Synthetic Biology And Strengthening Mission-Oriented Basic Research, Chenli Liu
Advancing Paradigm Of Quantitative Synthetic Biology And Strengthening Mission-Oriented Basic Research, Chenli Liu
Bulletin of Chinese Academy of Sciences (Chinese Version)
Synthetic biology is an important frontier in the life sciences, yet its further development remains constrained by limited capacity for rational design. Quantitative synthetic biology, which iteratively integrates quantitative modeling with the construction and analysis of synthetic systems, offers a promising paradigm for addressing this challenge. In this perspective, the study discusses the background and motivations underlying the emergence of this field and summarizes recent developments and exploratory efforts. Considering the unique characteristics of quantitative synthetic biology, it is suggested that progress in the field may benefit from strategically organized collaborative research that balances mission-oriented goals with investigator-driven exploration. On …
Air Pollution And Public Health: Global Evidence And Implications, Mohammed Obaid Al-Mansoori
Air Pollution And Public Health: Global Evidence And Implications, Mohammed Obaid Al-Mansoori
Al-Bahir
Globally, the issue of air pollution keep being one of most serious challenges that affecting environment and human health, coming from emissions of industries, transport, agriculture and also from the fuel people use in homes, in addition to natural events that make the situation worse. This review try to bring together the available evidences about the sources, types, and the health impacts of the main air pollutants, including the gaseous ones like SO₂, O₃, NO₂, and CO, and the particulate matter (PM₁₀, PM₂.₅). Exposure for short or long time to these pollutants is linked with many harmful outcomes, such as …
Analysis On Thermo-Viscous Steady Fluid Motion Over An Impermeable Infinitely Stretched Horizontal Moving Rectangular Surface, P. Krishna, N. Pothanna, K. Spandana
Analysis On Thermo-Viscous Steady Fluid Motion Over An Impermeable Infinitely Stretched Horizontal Moving Rectangular Surface, P. Krishna, N. Pothanna, K. Spandana
Mansoura Engineering Journal
This study presents analysis on thermo-viscous steady fluid motion over an impermeable infinitely stretched horizontal moving rectangular surface. The numerical results have been found employing R-K method of order 6 shooting techniques developed in Mathematica software ND solve for the flow adaptable equations comprising temperature and velocity. The flow behavior and the impacts of material constraints on the flow region have been analyzed and deliberated taking the help from the generated graphs. The variations of these flow fields have been studied for wide spectrum of physical characteristics which influences the nature of thermo-viscous fluid. The impact of viscosity, constant pressure …
Cap1 (Cyclase-Associated Protein 1) Mediates The Camp Regulation Of Adhesion And Proliferation Of Schwann Cells In The Peripheral Nervous System, Jarna Karmoker
Cap1 (Cyclase-Associated Protein 1) Mediates The Camp Regulation Of Adhesion And Proliferation Of Schwann Cells In The Peripheral Nervous System, Jarna Karmoker
Student Theses and Dissertations
The peripheral nervous system relays signals between the central nervous system and the rest of the body, and peripheral nerve injuries and neuropathies can cause permanent neurological deficits. Schwann cells (SCs) are glial cells that myelinate neurons, which is essential for neuronal function and nerve repair. CAP1 (Cyclase-Associated Protein 1) is best characterized as an actin-regulating protein, while it also regulates other cellular processes, including matrix adhesion, migration, and proliferation. We discovered that cAMP-induced CAP1 dephosphorylation regulates relevant cell functions. While cAMP is also important for SC function and myelination, the underlying mechanisms remain largely unknown. We silenced CAP1 in …
Fear Of Negative Evaluation And Intrinsic Motivation In Resistance-Trained Individuals: A Comparison Of Novice And Experienced Lifters, Karter Bokker
Fear Of Negative Evaluation And Intrinsic Motivation In Resistance-Trained Individuals: A Comparison Of Novice And Experienced Lifters, Karter Bokker
Student Theses and Dissertations
This study examined the relationship between fear of negative evaluation (FNE) and intrinsic motivation in resistance-trained individuals and compared FNE levels between novice and experienced lifters. Twenty-two male participants (n = 8 novices, n = 14 experienced) completed questionnaires assessing FNE and intrinsic motivation. A Pearson correlation and independent-samples t-test were conducted. Results indicated no significant relationship between FNE and intrinsic motivation (r = -.144, p = .523). However, novice lifters reported significantly higher FNE scores than experienced lifters, (t20) = 2.71, p = .014, with a large effect size (d = 1.20). These findings suggest that while FNE may …
Assessing The Effectiveness Of Wetland Reserve Easements As Habitat For Birds In The Mississippi Alluvial Valley Of Eastern Arkansas, Colin K. Dobson
Assessing The Effectiveness Of Wetland Reserve Easements As Habitat For Birds In The Mississippi Alluvial Valley Of Eastern Arkansas, Colin K. Dobson
Student Theses and Dissertations
Globally, wetland habitats suffered major declines during the 20th century. In the 1990s, the United States government created the Wetland Reserve Program (later consolidated into the Agricultural Conservation Easement Program), to combat the loss of wetlands. Despite success in attracting landowners, minimal monitoring of properties enrolled into the program (easements) has occurred. In this study, we monitored avian communities at easements, compared avian diversity at easements to agriculture and bottomland forests, and quantified microhabitat, site-specific, and surrounding landscape features at easements. We also studied the demographic rates of an indicator species of bottomland forests, the Prothonotary Warbler (Protonotaria citrea) at …
Efficacy Evaluation Of An Allopathic & Homeopathic Anthelmintic On Small Ruminant Parasite Loads, Kennon Leigh Harrington
Efficacy Evaluation Of An Allopathic & Homeopathic Anthelmintic On Small Ruminant Parasite Loads, Kennon Leigh Harrington
Student Theses and Dissertations
This study aimed to compare the efficacy of an allopathic and homeopathic anthelmintic in sheep and goats naturally infected with internal parasites. Animals with a threshold of ≥1000 EPG (n=30) were enrolled. The allopathic group received a single 14.79 mL per 50 lbs. BW drench solution of Prohibit®. The homeopathic group received a mixed herbal aqueous suspension, 2x/day D1-D3, thereafter 2x/day once a week W1-W4. There was an effect of anthelmintic treatment (P=0.0234) and day (P=0.0116) on total EPG, but no interaction effect for treatment by day (P=0.2440). For Initial sampling, there was a weak correlative tendency between weight and …
Enhancer Rna Transcription Near Segmentation Gene Enhancers Can Be Analyzed In Situ Using Fish, Christine Mau, Benjamin Schmid, Ezzat El-Sherif
Enhancer Rna Transcription Near Segmentation Gene Enhancers Can Be Analyzed In Situ Using Fish, Christine Mau, Benjamin Schmid, Ezzat El-Sherif
School of Integrative Biological & Chemical Sciences Faculty Publications
Enhancer RNAs (eRNAs) are non-coding transcripts produced at enhancer regions, which appear to be involved in transcriptional regulation. Up to date, these have been primarily investigated using labor- and cost-intensive genomic techniques. However, the precise mechanisms by which eRNA transcription or eRNA transcripts themselves mediate transcriptional regulation remain unclear. Here, we present a novel experimental approach that allows us to analyze characteristics of eRNA transcription in fixed and live whole Drosophila melanogaster embryos. We employ the anterior–posterior patterning genes as a model system to investigate the dynamics of eRNA expression, utilizing an imaging-based approach. We combined high-sensitivity fluorescence in situ …
Natural Behavior Vs. Subjective Experience In Fish Welfare Assessments, Ronald G. Oldfield
Natural Behavior Vs. Subjective Experience In Fish Welfare Assessments, Ronald G. Oldfield
Animal Sentience
Several commentaries on the Oldfield & Bonano (2024) target article proposed that natural behavior should play a larger role in assessing the welfare of fishes in zoos and aquariums. However, the natural-behavior concept of animal welfare has been widely criticized because natural behaviors do not necessarily improve welfare, and unnatural behaviors do not necessarily reduce it. I review the three major concepts of animal welfare — physical health, natural behavior, and affect/feelings — and argue that behavior patterns, whether natural or otherwise, should be evaluated according to their effects on health and subjective experience. Using the affect/feelings concept and the …
Reproductive Trends Of Male Atlantic Spotted Dolphins (Stenella Frontalis) Following Two Hurricanes In The Bahamas, Tara Southerland Pedersen
Reproductive Trends Of Male Atlantic Spotted Dolphins (Stenella Frontalis) Following Two Hurricanes In The Bahamas, Tara Southerland Pedersen
USF Tampa Graduate Theses and Dissertations
Marine mammals are impacted by hurricanes that may influence reproductive success and genetic diversity. Understanding how populations respond to demographic change is increasingly important as extreme weather events become more frequent. A population of Atlantic spotted dolphins (Stenella frontalis) on Little Bahama Bank in the Bahamas has been observed continuously since 1985. In 2004, two hurricanes struck the region within one month, resulting in the loss of approximately 36% of the population. Population declines can alter the operational sex ratio (OSR), social structure, and encounter rates among potential mates, potentially influencing patterns of reproductive success. Previous molecular studies showed that …
Contribution Of Animals To Biomedical Advancements In The Current Era: A Narrative Review, Leena Rajathy Port Louis, Mani Rajarathinam, Prithiviraj Nagarajan, Divya Sekar, Nisha Perumal
Contribution Of Animals To Biomedical Advancements In The Current Era: A Narrative Review, Leena Rajathy Port Louis, Mani Rajarathinam, Prithiviraj Nagarajan, Divya Sekar, Nisha Perumal
The Thai Journal of Pharmaceutical Sciences
Animal research has played a major role in the development of vaccinations and therapies for illnesses such as tetanus, polio, meningitis, hepatitis, and Severe Acute Respiratory Syndrome Coronavirus 2. For every prescription drug available today, animal testing and research have contributed immensely. This narrative review aims to explore the contribution of animals to biomedical advancements in the current era, which involved a search of peer-reviewed literature using electronic databases such as Scopus, Web of Science, and PubMed. In current biomedical research, animals help develop new treatments for long-term illnesses such as cancer, HIV, and Alzheimer’s. Animals also aid in the …
Anti-Inflammatory Activities Of Muntingia Calabura L. In Monosodium Urate-Induced Acute Gout Arthritis: Regulation Of Nlrp3 And Il-1Β, Nita Parisa, Eva Rianty, Nia Savitri Tamzil, Debby Handayati Harahap, Veny Larasati, Bintang Arroyantri Prananjaya, Theodorus Theodorus
Anti-Inflammatory Activities Of Muntingia Calabura L. In Monosodium Urate-Induced Acute Gout Arthritis: Regulation Of Nlrp3 And Il-1Β, Nita Parisa, Eva Rianty, Nia Savitri Tamzil, Debby Handayati Harahap, Veny Larasati, Bintang Arroyantri Prananjaya, Theodorus Theodorus
The Thai Journal of Pharmaceutical Sciences
Background: Acute gout arthritis, which is caused by hyperuricemia, is a common inflammatory joint disease, leading to monosodium urate (MSU) crystal deposition. These crystals trigger inflammation, causing pain and significantly impairing the patient’s quality of life. Colchicine is commonly used to treat and prevent acute gout arthritis, but it has several side effects. Cherry tree (Muntingia calabura L.) leaves, which possess anti-inflammatory properties, show promise as an alternative treatment. The potential benefit of the leaves may be due to the flavonoid content.
Objectives: This study aimed to assess the anti-inflammatory activities of cherry tree leaves in an MSU-induced acute …
Adaptative And Structured Optimization Stockwell Transform For Robust Power-Quality Disturbances Detection, Moudjibatou Afoda, Séna Apeke, Filippo Gatti, Alessio Iovine, Léonce W. Tokam, Guy M. Toche Tchio, Ouro-Djobo S. Sanoussi
Adaptative And Structured Optimization Stockwell Transform For Robust Power-Quality Disturbances Detection, Moudjibatou Afoda, Séna Apeke, Filippo Gatti, Alessio Iovine, Léonce W. Tokam, Guy M. Toche Tchio, Ouro-Djobo S. Sanoussi
Mansoura Engineering Journal
The monitoring of electrical power quality requires advanced analysis techniques capable of accurately detecting and localizing non-stationary disturbances. This work proposes a structured and adaptive optimization of the Stockwell Transform (ST), referred to as Two-Power Optimization (TPO). A multiparametric Gaussian window governed by four parameters (m, p, k, r), is introduced, and a genetic algorithm is applied independently to each signal to optimize these parameters. The optimization process adapts the analysis scale to the local characteristics of the signal while preserving the physical consistency of the window function. Simulation results on synthetic power quality signals demonstrate that the proposed method …
Finite Element Modelling On A Non-Linear Radiative Hybrid Nanofluid Flowing Through A Rotating Disk, N. Janaki Phani Madhuri, Md. Shamshuddin
Finite Element Modelling On A Non-Linear Radiative Hybrid Nanofluid Flowing Through A Rotating Disk, N. Janaki Phani Madhuri, Md. Shamshuddin
Mansoura Engineering Journal
This study develops a finite element model to investigate the MHD flow and heat transfer phenomena of Cu–H₂O and Cu–Fe₃O₄–H₂O hybrid nanofluids flow across a spinning disk modelling by the Tiwari–Das model. The governing non-dimensional momentum and energy equations account for the effects of buoyancy, nonlinear radiation, and ohmic heating. The nonlinear coupled system is solved with the element method (FEM) to find the velocity and temperature fields. Parametric studies will investigate the effects of the magnetic field, buoyancy, volume fraction of nanoparticles, and radiation. Skin friction and Nusselt number are also reported. The results show that with the hybrid …
Real-Time Iot-Enabled Dissolved Oxygen Monitoring And Automated Wastewater Recirculation In Constructed Wetlands, Sivasankar Pandiarajan, Vanitha Sankararajan, Devarinti Chandu
Real-Time Iot-Enabled Dissolved Oxygen Monitoring And Automated Wastewater Recirculation In Constructed Wetlands, Sivasankar Pandiarajan, Vanitha Sankararajan, Devarinti Chandu
Mansoura Engineering Journal
Wastewater treatment is necessary for environmental conservation and combating water pollution. This study demonstrates real-time dissolved oxygen (DO) monitoring in constructed wetland treatment. The system would ensure an adequate supply of oxygen through automated water circulation whenever the level is below 4 mg/L, and shut down when it reaches the normal level. From experiments conducted, it was observed that within three automated circulation processes, it is possible to increase DO concentrations from 0.5 mg/L to 5.0 mg/L. Additionally, Total Dissolved Solids reduced from 1,380 ppm to 920 ppm. pH also stabilized from 8.38 to 7.9. In this system, data is …
Bridging Machine Learning And Climate Futures: A Framework For Explainable, Self-Directed (Agentic) Ai Models In Monitoring, Mitigation, And Governance Of Anthropogenic Climate Impacts, Vijayanandh Rajamanickam, Ketaki Kulkarni, Vishwanadham Mandala, Ozgur Kisi
Bridging Machine Learning And Climate Futures: A Framework For Explainable, Self-Directed (Agentic) Ai Models In Monitoring, Mitigation, And Governance Of Anthropogenic Climate Impacts, Vijayanandh Rajamanickam, Ketaki Kulkarni, Vishwanadham Mandala, Ozgur Kisi
Mansoura Engineering Journal
Environmental and societal damage due to anthropogenic climate change demands detection and mitigation strategies that are both effective and accountable. Machine Learning (ML) appears to offer a powerful set of tools but remains unexploited in these areas. A key barrier remains its poor ability to draw causal inferences about external systems, an essential requirement for meaningful continued monitoring, acting on, and shaping of the climate. Explainable, self-directed learned models operate by attributing environmental changes and deciding how best to model the resulting dynamics—they offer a natural solution. Recent developments in computational ecology, meteorology, and ML are combined to propose a …
Ameliorating Chromium-Induced Stress In Maize Through Phosphorus And Melatonin Application, Zunaira Zafar, Shoaib Ahmad, Muhammad Akhtar, Shafaqat Ali, Sarah Owdah Alomrani, Muhammad Ali Alshehri
Ameliorating Chromium-Induced Stress In Maize Through Phosphorus And Melatonin Application, Zunaira Zafar, Shoaib Ahmad, Muhammad Akhtar, Shafaqat Ali, Sarah Owdah Alomrani, Muhammad Ali Alshehri
Turkish Journal of Agriculture and Forestry
Chromium (Cr+6) toxicity is a significant environmental stress factor that severely hampers plant growth and productivity. This study aimed to evaluate whether the combined application of phosphorus fertilizer and melatonin could alleviate chromium induced stress in maize (Zea mays L.). A foliar spray of melatonin (50 µM) was applied alongside two phosphorus sources—phosphoric acid (PA) and diammonium phosphate (DAP), each at 60% of the recommended rate. Two maize cultivars (FH-1046 and YH-1898) were grown under chromium stress (0, 15, and 30 mg kg–1) to assess treatment effects. The results demonstrated that FH-1046 plants treated with PA + melatonin under noncontaminated …
The Change Of Yield, Growth, And Fruit Quality In Rubygem Strawberry Using Arbuscular Mycorrhizal Species, Selma Kuru Berk
The Change Of Yield, Growth, And Fruit Quality In Rubygem Strawberry Using Arbuscular Mycorrhizal Species, Selma Kuru Berk
Turkish Journal of Agriculture and Forestry
Arbuscular mycorrhizal fungi (AMF), which exist symbiotically with plant roots, affect plant growth, yield, and fruit quality. The effects of AMF vary depending on the cultivar and mycorrhizal type. In this study, the effects of different AMF types on the Rubygem strawberry cultivar, widely grown in Türkiye, were examined. Gigaspora margarita and Funneliformis mosseae AMF species were applied to plant roots at seedling planting. Fruit quality criteria, including yield, acidity, soluble solid content, phenolic compounds, organic acids, crown and root development, and the number of daughter plants and stolons, were examined. The highest yield was 431.02 g in G. margarita. …
The Core Microbiome Of Fluvisols From The Vistula River Valley: Relationships Between Bacteria And Basic Soil Properties, Karolina Furtak, Anna Marzec-Grządziel, Jarosław Grządziel, Jacek Niedźwiecki
The Core Microbiome Of Fluvisols From The Vistula River Valley: Relationships Between Bacteria And Basic Soil Properties, Karolina Furtak, Anna Marzec-Grządziel, Jarosław Grządziel, Jacek Niedźwiecki
Turkish Journal of Agriculture and Forestry
Fluvisols develop in river valleys through the accumulation of alluvial sediments. They are characterised by high fertility and are extensively used for agriculture. This study aimed to identify the core microbiome of fluvisols in the Vistula Valley and to examine its relationship with the basic physicochemical properties of the soils. Six types of fluvisol (very light, light, medium, and heavy) from four locations in Lublin province were analysed, with samples collected in 2018 and 2022. The microbiome structure was determined by sequencing the V3–V4 region of the 16S rRNA gene and was compared with soil parameters such as pH, electrical …
Multidimensional Scaling (Mds) Analysis Of Fire Blight Resistance In Apple Genotypes Selected From The Eastern Black Sea Region Of Türkiye, Kubi̇lay Kurtuluş Baştaş, Hati̇ce Dumanoğlu, Veli̇ Erdoğan, Ahmet Aygün, Rabi̇a Albayrak Deli̇ali̇oğlu, Sai̇d Efe Dost, Ümi̇t Serdar, Özgün Kalkişim, Sali̇h Maden, Zahi̇de Kocabaş
Multidimensional Scaling (Mds) Analysis Of Fire Blight Resistance In Apple Genotypes Selected From The Eastern Black Sea Region Of Türkiye, Kubi̇lay Kurtuluş Baştaş, Hati̇ce Dumanoğlu, Veli̇ Erdoğan, Ahmet Aygün, Rabi̇a Albayrak Deli̇ali̇oğlu, Sai̇d Efe Dost, Ümi̇t Serdar, Özgün Kalkişim, Sali̇h Maden, Zahi̇de Kocabaş
Turkish Journal of Agriculture and Forestry
Erwinia amylovora is the causal agent of fire blight, which is known as one of the most destructive diseases of apple. The use of fire blight-resistant cultivars/rootstocks is one of the most effective methods available to manage this disease. We previously selected 199 local apple cultivars that showed no clearly visible symptoms of fire blight on the plants from the coastline of the eastern Black Sea Region in Türkiye. The region is characterized by the highest rainfall and humidity levels in the country. In this research, young plants of these genotypes grafted onto MM.106 rootstock were screened for fire blight …
Derived Smoke Solution Mitigates Drought Stress In Forage Pea By Enhancing Antioxidant Defense Mechanisms, Medi̇ne Çopur Doğrusöz
Derived Smoke Solution Mitigates Drought Stress In Forage Pea By Enhancing Antioxidant Defense Mechanisms, Medi̇ne Çopur Doğrusöz
Turkish Journal of Agriculture and Forestry
This study was conducted to enhance plant resilience against drought stress, a major threat to agricultural production, by utilizing an eco-friendly application derived from agricultural waste. We investigated the protective effect of a smoke solution, derived from poppy harvest residues, on the biometric and biochemical parameters of two forage pea (Pisum sativum spp. arvense L.) varieties (GAP Pembesi and Özkaynak). Seeds were primed with 1% and 10% smoke solutions and grown under three distinct conditions: normal irrigation (control), moderate drought, and severe drought. Parameters including biometric traits, chlorophyll pigments, secondary metabolites, and antioxidant enzyme activities were analyzed. The smoke solution …
Intrathecal (G4c2)149 Delivery In C9orf72-Deficient Mice Yields Mild Motor Dysfunction And Als/Ftd Pathological Hallmarks, Katelyn Russell, Amelia Shahrabi, Suleyman Akerman, Matthew D. Byrne, Jeffrey Rothstein, Davide Trotti, Brigid Jensen, Aaron Haeusler
Intrathecal (G4c2)149 Delivery In C9orf72-Deficient Mice Yields Mild Motor Dysfunction And Als/Ftd Pathological Hallmarks, Katelyn Russell, Amelia Shahrabi, Suleyman Akerman, Matthew D. Byrne, Jeffrey Rothstein, Davide Trotti, Brigid Jensen, Aaron Haeusler
Farber Institute for Neuroscience Faculty Papers
A repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), yet existing mouse models incompletely engage spinal regions implicated in disease. Here, an adeno-associated virus encoding (G4C2)149 repeats was delivered via neonatal intrathecal injection, achieving widespread CNS expression with robust spinal cord targeting. This approach was applied to mice with graded loss of endogenous C9orf72 to interrogate both gain- and loss-of-function mechanisms. Longitudinal motor, behavioral, and pathological analyses revealed that repeat expression primarily drives mild, progressive muscle weakness, whereas coordination deficits were largely genotype dependent. Subtle gait abnormalities and hyperactivity …
Prediction Of Furniture Exports In Türkiye Using Machine Learning Methods, İlker Akyüz, Nadi̇r Ersen, Ti̇muçi̇n Bardak, Selahatti̇n Bardak
Prediction Of Furniture Exports In Türkiye Using Machine Learning Methods, İlker Akyüz, Nadi̇r Ersen, Ti̇muçi̇n Bardak, Selahatti̇n Bardak
Turkish Journal of Agriculture and Forestry
In this study, it was aimed to predict Türkiye’s furniture exports for the period from January 2010 to May 2025 using machine learning methods based on macroeconomic indicators. The dataset consisted of 10 economic variables, including the furniture industry production index, capacity utilization rate, import volume, total exports, real effective exchange rate, producer price index, money supply, and oil prices, with 185 observations per variable and a total of 2035 data points. During the data preprocessing phase, no missing or outlier values were detected, and the data were divided into 70% training and 30% testing subsets. Decision tree, random forest, …
Ozonated Water Delays The Microbial Growth And Sensory Quality Loss Of Capia Pepper Fruit During Cold Storage, Yasi̇n Şi̇mşek, Mehmet Ali̇ Koyuncu, Derya Erbaş
Ozonated Water Delays The Microbial Growth And Sensory Quality Loss Of Capia Pepper Fruit During Cold Storage, Yasi̇n Şi̇mşek, Mehmet Ali̇ Koyuncu, Derya Erbaş
Turkish Journal of Agriculture and Forestry
The aim of the present research was to evaluate, for the first time, the effect of ozonated water treatments on the postharvest quality of capia pepper (Capsicum annuum L. ‘Kaptan’). The peppers were harvested at the optimum time and transported to the laboratory immediately. Uniform and quality fruit was selected and precooled. After precooling, the fruit was divided into four groups. The first three groups were immersed in ozonated water at three different concentrations (1.0, 2.0 and 3.0 ppm) for 15 min. The last group (control) was immersed in distilled water for 15 min. The peppers were kept at room …
Describing Propagation Of Carbapenem-Resistant Acinetobacter Baumannii Through Comparative Genomics And Phenotypic Analysis Of Modern-Day Clinical Isolates, Emma Graffice
ETDs from 2020-2029
Understanding the genomic structure of bacterial populations is essential for tracking antimicrobial resistance and informing public health strategies to prevent spread of multidrug resistant organisms. In this study, we investigated the diversity and distribution of carbapenem-resistant Acinetobacter baumannii (CRAb) lineages across a major healthcare system in the U.S. Deep South through both retrospective and prospective isolate collection. Our analysis revealed a heterogeneous population composed of multiple genotypically and phenotypically distinct lineages. To improve the resolution of lineage classification, we applied average nucleotide identity (ANI) as a high-resolution metric for comparative genomics. A ≥99% ANI threshold effectively delineated lineages, outperforming traditional …
Contribution Of Phosphorylation To Hp1a Function, James Walts
Contribution Of Phosphorylation To Hp1a Function, James Walts
ETDs from 2020-2029
Heterochromatin Protein 1 (HP1) family members are highly conserved, non-histone chromosomal proteins essential for heterochromatin formation and transcriptional regulation. In Drosophila melanogaster, HP1a functions both as a transcriptional repressor and activator, as well as other functions, and undergoes post-translational modifications, including phosphorylation. The functional consequences of HP1a phosphorylation remain largely unexplored. This thesis investigates the role of phosphorylation at serines 89/90/91 (S899091) of HP1a by generating two mutant alleles: a phospho-mimic (SE) and a phospho-block (SA). Both alleles produce stable mRNA transcripts; however, Western blot analysis revealed reduced protein accumulation relative to wildtype HP1a. Homozygous phospho-block animals are embryonic lethal …