Life Sciences Commons^™

Exploring The Salinity Tolerance Of Zooplankton Communities On The Great Plains, Abbeneet Binning Bath, Derek Gray

Theses and Dissertations (Comprehensive)

Palaeoecological data shows fluctuating salinity levels in lakes across the Great Plains due to alternating wet and dry periods over the last two millennia. Droughts caused by this natural variation may be exacerbated by anthropogenic climate change, as the Great Plains are expected to become drier over the coming decades. As conditions become drier, the evaporation of water will increase the salinity of lakes across the region. Increases in salinity may significantly impact biodiversity, including important members of lake food webs such as zooplankton. Due to the region's history of alternating wet and dry periods, zooplankton may have adapted to …

Impact Of Membrane Lipid Composition On The Structure And Function Of Uncoupling Proteins 1 And 2 From Arabidopsis Thaliana (Atucp1 And Atucp2), Elizabeth Silva

Theses and Dissertations (Comprehensive)

A proton gradient across the inner mitochondrial membrane (IMM) is required for the synthesis of adenosine triphosphate (ATP) via ATP synthase. In other words, generation of the proton gradient is coupled to the synthesis of ATP. Interestingly, uncoupling proteins (UCPs), also located in the IMM, dissipate the proton gradient, meaning that the gradient is not efficiently used for the production of ATP.¹ The mechanism of proton transport activity of UCPs has been hypothesized and widely debated for the past 20 years to also reduce oxidative stress by reducing the production of reactive oxygen species (ROS).² The majority of …

Timing Of Migration And Seasonal Movements Of Arctic Grayling (Thymallus Arcticus) In Relation To Water Temperature In The Kakisa River And Upper Mackenzie River, Nwt: Results From An Acoustic Telemetry Study., Levi Snook

Theses and Dissertations (Comprehensive)

Arctic grayling (Thymallus arcticus) are a cold-water salmonid that inhabit waterbodies throughout the circumpolar regions of the northern hemisphere. In the last decade, Ka'a'gee Tu First Nation members as well as local sport fishers, have observed lower catches of Arctic grayling during their annual spawning run in the Kakisa River, NWT. Many potential causes of this decline have been hypothesized including climate change and over harvesting. Outside of the general annual spawning activity in the headwaters of the Kakisa River, the ecology of the population, including post-spawn habitat use and migratory patterns, remained understudied. To address these knowledge gaps, acoustic …

Marine And Freshwater Habitats Used By Sympatric Anadromous Arctic Char (Salvelinus Alpinus) And Dolly Varden (S. Malma Malma) In The Central Canadian Arctic, Simon W. Depasquale Mr.

Theses and Dissertations (Comprehensive)

Two closely related but distinct species of char, Arctic Char (Salvelinus alpinus) and Dolly Varden (S. malma), are critically important to the food security and culture of Indigenous peoples in northern North America. Subsistence Inuit fishers in Kugluktuk, NU, Canada, have noticed changes in the timing and locations of their catches of char in the past ~ 10 years. In response, an ongoing partnered research program between the Kugluktuk Hunters and Trappers Organization (HTO) and scientists was formed to study Arctic Char and northern form Dolly Varden (S. malma malma). Char research near Kugluktuk presents a unique opportunity to further …

Characterizing The Targeting Of Toc159 Receptors To The Chloroplast Outer Envelope Membrane And Their Role In The Assembly Of Distinct Toc Complexes, Michael Fish

Theses and Dissertations (Comprehensive)

Global agriculture and food security face challenges from climate change, population growth, and other human-driven pressures. Enhancing our understanding of plant biology, particularly chloroplast function, is critical for improving crop yield and stress resilience. As the sites of photosynthesis and key regulators of plant responses to environmental cues, chloroplasts depend on the precise import of thousands of nuclear-encoded proteins to maintain their biogenesis and function. While much is known about the core translocon components in the chloroplast outer envelope membrane that form the TOC complex, the mechanisms underlying their targeting, assembly, and regulation remain incompletely understood.

Plastids, including chloroplasts, evolved …

Immune Pathway Modulation In Melanoma Using Chitosan Nanoparticle-Mediated Dsrna Delivery, Bethel C. Iwuji

Theses and Dissertations (Comprehensive)

Cancer is a group of diseases characterized by abnormal and uncontrolled cell division, which typically results in the formation of tumours. Even with advances in treatments, cancer remains one of the leading causes of death globally. Melanoma is an aggressive form of skin cancer which is highly malignant, develops in the pigment-producing cells of the skin, melanocytes, and in the late stages of the disease poses a significant challenge for therapeutic intervention due to its multidrug resistance. The innate immune system is the first line of defence against invading pathogens, including viruses, bacteria, and fungi, and can recognize and destroy …

Macroinvertebrate Communities And Food Web Structure In Tundra Streams Are Shaped By Substrate Size And Beaver Impoundments, Mathew K. Mervyn

Theses and Dissertations (Comprehensive)

North American beavers (Castor Canadensis) are expanding their range into the Arctic tundra as climate change drives earlier ice and snowmelt, and increased shrub cover. As ecosystem engineers, beavers build dams that alter water chemistry by creating impoundments within streams, trapping sediment and organic matter, and modifying nutrient cycling. This thesis evaluates how beaver impoundments interact with natural geomorphic variation in tundra streams and how impoundments affect tundra freshwater ecosystems in the western Canadian Arctic.

In Chapter 2, I compared water chemistry and benthic macroinvertebrate (BMI) community composition across 16 stream reaches, including those with and without beaver dams, with …

Fisheries Research Report No. 345: Metropolitan Monitoring Program 2024, Alissa C. Tate, Claire B. Smallwood, Karina L. Ryan

Fisheries Research Reports

Ongoing monitoring of recreational fisheries in the Metropolitan zone is essential to ensure the sustainable use of fisheries resources. Surveys of shore- and boat-based recreational fishers within the Metropolitan zone of the West Coast bioregion provide information on human dimensions and catch-per-fisher as well as mean length and weight of key recreationally caught species. For shore-based fishers, estimates of fishing effort, catch and harvest are also presented for key nearshore species. Information in this report is used to support ongoing assessments for key nearshore species and inform the development and evaluation of harvest strategies and other management actions, such as …

Sifting Wheat: Structural Determinants Of Us Wheat Pricing, Caleb Kevin Brown

Theses and Dissertations--Agricultural Economics

Soft red winter (SRW) wheat basis reflects local demand conditions influenced by a range of structural and market factors. This study describes market signaling through carry and basis, arbitrage opportunities in SRW wheat, and the advantages or disadvantages of different grain origination contracts. A hedonic modeling framework, using observations pooled by futures board period, evaluated the seasonal drivers of wheat basis. A panel dataset was constructed from public and private sources and aggregated to the United Stated Department of Agriculture (USDA) Agricultural District level. Explanatory variables included regional milling capacity, mill storage, NASS wheat production, diesel price, rail car cost, …

The Theory Of Evolution, Alois Nicholas Wurst

Bachelors’ Theses

What is perhaps one of the most fascinating questions in the scientific and philosophical world today is the theory on the Decent of Man. We hear much concerning Evolution. New theories on the subject appear almost daily. Most of these seem to be hoaxes on the part of publicity hungry scientists. If a man would have his name in newspapers the world over, he must only say that he produced a living organism out of inanimate matter. Of course such a statement produces a sensation. But this sensation is short lived. Investigation usually exposes prevarication on the part of the …

Characterizing Niche Specialization In Staphylococcus Epidermidis, Sandra Jablonsk

Dissertations

This thesis investigates the microbial diversity of Staphylococcus epidermidis (S. epidermidis) across various anatomical sites in the human body. While traditionally viewed as a benign skin microbe, S. epidermidis also inhabits the urinary, gastrointestinal, and respiratory tracts, raising questions about its genetic variation and adaptability in different environments. The research aims to compare strains of S. epidermidis isolated from the oral cavity, nostrils, urinary tract, and skin of healthy individuals to determine if they share a common ancestor or if they evolved independently in response to specific environmental factors. The study comprises three main aims. Aim 1 focuses on assessing …

Computational Analysis And Characterization Of The Inducible 1-Cysteine Peroxiredoxin Promoter In The Malaria Parasite Plasmodium, Lara Ladney

Dissertations

Malaria afflicts over 200 million people annually, which results in over half a million deaths, primarily in sub-Saharan Africa. Malaria parasites are complex protozoan organisms that inhabit two hosts: humans, the site of asexual reproduction, and the Anopheles mosquito, where sexual reproduction occurs. To withstand the hostile extracellular environment of the Anopheles mosquito, the malaria parasite Plasmodium berghei employs antioxidant defense mechanisms. Previous work suggests upregulation of 1-Cysteine Peroxiredoxin (1-CPxn) when the mosquito uptakes a blood meal containing the parasite. The parasite must acclimate to the harsh environmental conditions of the mosquito midgut: find a way to counteract reactive oxygen …

Analyzing The Population Structure Of The Rhizobia Associated With Astragalus Lentiginosus, Joshua Adam Melnick

Dissertations

Legumes are an incredibly diverse and agriculturally important family of plants. They have a special relationship with symbiotic bacteria known as rhizobia which fix nitrogen into ammonia within nodules on their roots. Astragalus is the largest plant genus on Earth, and the species Astragalus lentiginosus is extraordinarily diverse, consisting of approximately 40 varieties. However, the rhizobia of A. lentiginosus have never been studied. In this study, root nodules were extracted from 17 varieties of A. lentiginosus to obtain rhizobial strains and metagenomes. A. lentiginosus primarily associates with rhizobia from the genera Mesorhizobium and Allomesorhizobium. There was little evidence of horizontal …

Toll-Like Receptor Signaling In Neurons Modulates C. Elegans Feeding Behavior In A Hunger State-Dependent Manner, Neel Patel, Joseph Rios, Retwika Ganguly, Cindy Mutafoglu, Nour Shalash, Karla Gallardo, Malak Saleh, John Chahine, Emily Kopecky, Gursimran Gujral, Kamya Shah, Christos Suriano

Department of Biology Faculty Scholarship and Creative Works

Animals face the risk of encountering pathogenic microbes while foraging for resources. Assessing the risk of nutrition vs. infection can result in the behavioral regulation of immune processes. Behavioral immunity in the nematode roundworm Caenorhabditis elegans (C. elegans) is regulated, in part, by the innate immune molecule TOL-1: a homolog of vertebrate Toll-like Receptor (TLR) proteins that influences C. elegans pathogen avoidance behaviors by promoting the development of CO2-detecting chemosensory neurons. While TOL-1′s role in pathogen avoidance is well established, its role in an opposing behavior – foraging – has not been examined. In addition to pathogenic bacteria, preferred food …

Microbial Mavericks: Turning Hazards Into Snacks, Alison G. Blanton

Biology Dissertations - Archive

Symbiotic associations with microbes are widespread across life and provide hosts with essential and beneficial functions. A growing concern in pest management is symbiont-mediated detoxification (SMD), a form of metabolic resistance to insecticides. The best-known example of SMD involves the bean bug Riptortus pedestris, where an environmentally acquired but obligate Caballeronia symbiont confers resistance to the organophosphorus insecticide fenitrothion. Motivated by this model, I began my work in another known bug-Caballeronia symbiosis: Leptoglossus phyllopus, native to the United States. I then expanded the study to include two additional U.S.-native hosts, Leptoglossus zonatus and Anasa tristis. Representative …

Interspecific Interactions And Resource Availability As Drivers Of Species Occurrences, Edita Folfas

Biology Dissertations - Archive

Understanding what forces determine species occurrence is central to studies of community ecology. Species interact with each other and their environment, and these interactions scale up to shape global patterns of diversity. In my first chapter, I examined how predation might shape patterns of Anolis lizard species richness and abundance across landscapes on islands in the Greater Antilles. I quantified predatory bird occurrence by using thousands of observations from an online citizen science database (eBird). I then obtained estimates of anole abundance and diversity by conducting local field surveys and using mark-resight methods. While predators could negatively impact anole abundance …

A Pyrrole Modified 3,4-Propylenedioxythiophene Conjugated Polymer As Hole Transport Layer For Efficient And Stable Perovskite Solar Cells, Yuanhao Tang, Ke Ma, Wenhao Shao, Yoon Ho Lee, Ashkan Abtahi, Jiaonan Sun, Hanjun Yang, Aidan H. Coffey, Harindi R. Atapattu, Mustafa Ahmed, Qixuan Hu, Wenzhan Xu, Raunak Dani, Limei Wang, Chenhui Zhu, Kenneth R. Graham, Jianguo Mei, Letian Dou

Chemical and Materials Engineering Faculty Publications

Despite the outstanding electric properties and cost-effectiveness of poly- (3,4-ethylenedioxythiophene) (PEDOT) and its derivatives, their performance as hole transport layer (HTL) materials in conventional perovskite solar cells (PSCs) has lagged behind that of widely used spirobifluorene-based molecules or poly(triaryl amine). This gap is mainly from their poor solubility and energy alignment mismatch. In this work, the design and synthesis of a pyrrole-modified HTL (PPr) based on 3,4-propylenedioxythiophene (ProDOT) are presented for efficient and stable PSCs. As a result of the superior defects passivation ability, excellent contact with perovskite, enhanced hole extraction, and high hydrophobicity, the unencapsulated PPr-based PSCs showed the …

Cardiac Injury Regulates Neuroinflammation Through Extracellular Vesicle–Mediated Heart-Brain Crosstalk, Qingxuan Li, Ramzi H. Hamdalla, Neha Dhyani, Lijun Sun, Lie Gao, Tara L. Rudebush, Irving H. Zucker, Changhai Tian

Toxicology and Cancer Biology Faculty Publications

Cognitive impairment is common in heart failure patients, contributing to morbidity and mortality. This impairment may be linked to neuroinflammation in heart failure. However, the primacy of the heart-brain axis remains to be completely understood. Here, we elucidate the potential effects of myocardial injury on pathways and inflammatory mediators responsible for cognitive impairment using a rodent myocardial injury model. The results demonstrate direct extracellular vesicle (EV)-mediated heart-brain crosstalk and the glial uptake of cardiac EVs. In addition, brain inflammation was also elicited following myocardial injury. Moreover, cardiac EVs promote brain microglial cell activation in vitro, potentially mediated by EV-enriched micro-RNAs …

Exploring The Links Among Brain Iron Accumulation, Cognitive Performance, And Dietary Intake In Older Adults: A Longitudinal Mri Study, Valentinos Zachariou, Colleen A. Pappas, Christopher E. Bauer, Elayna R. Seago, Brian T. Gold

Neurology Faculty Publications

This study evaluated longitudinal brain iron accumulation in older adults, its association with cognition, and the role of specific nutrients in mitigating iron accumulation. MRI-based, quantitative susceptibility mapping estimates of brain iron concentration were acquired from seventy-two healthy older adults (47 women, ages 60–86) at a baseline timepoint (TP1) and a follow-up timepoint (TP2) 2.5–3.0 years later. Dietary intake was evaluated at baseline using a validated questionnaire. Cognitive performance was assessed at TP2 using the uniform data set (Version 3) neuropsychological tests of episodic memory (MEM) and executive function (EF). Voxel-wise, linear mixed-effects models, adjusted for longitudinal gray matter volume …

A Unique Inflammaging Profile Generated By T Cells From People With Obesity Is Metformin Resistant, S. Santacruz‑Calvo, S. Saraswat, Gabriella Kalantar, E. Zukowski, H. Marszalkowski, Aida Javidan, F. Gholamrezaeinejad, L. P. Bharath, P. A. Kern, X. D. Zhang, Barbara S. Nikolajczyk

Pharmacology and Nutritional Sciences Faculty Publications

The alarmingly high prevalence of obesity in older adults coupled with the negative health effects of chronic inflammation in both obesity and aging highlight the importance of studies investigating the impacts of obesity on age-related inflammation. Since shifts in peripheral T-cell metabolism and function drive systemic inflammation in both obesity and aging, we hypothesize that obesity impacts the Th17-dominated inflammaging profile we identified in lean subjects and thus modifies the anti-inflammatory effects of geroprotective drugs like metformin. New cytokine profiling data showed that CD4+ T cells from older people with obesity generate a profile that specifically excludes Th17 cytokines. Metformin …

Bilirubin Hepatic And Intestinal Transport And Catabolism: Physiology, Pathophysiology, And Benefits, Zachary A. Kipp, Sally N. Pauss, Genesee J. Martinez, Terry D. Hinds, Jr., Wang-Hsin Lee

Pharmacology and Nutritional Sciences Faculty Publications

Bilirubin, a metabolite derived from heme degradation, has traditionally been regarded as a waste product and a marker of liver injury. However, increasing evidence suggests that bilirubin also functions as a hormone, and reduced levels are associated with metabolic dysfunction. Studies have shown a strong association between low circulating bilirubin levels and an increased risk of metabolic disorders and cardiovascular disease. To advance bilirubin-based treatment strategies, it is essential to elucidate the mechanisms underlying bilirubin transport and metabolism. Therefore, we provide an in-depth discussion of bilirubin production and its subsequent fates, with a particular focus on the transport between the …

Cd47: An Immunoregulatory Nexus In Liver And Gastrointestinal Disorders, Josephine Otuagomah, Alana Newcomb, Taesik Gwag, Shuxia Wang

Pharmacology and Nutritional Sciences Faculty Publications

Cluster of differentiation 47 (CD47) is a widely expressed transmembrane protein that serves as a critical immunoregulatory checkpoint in both homeostatic and pathological conditions of the digestive system. It interacts with signal regulatory protein alpha to send a ‘do not eat me’ signal, thereby preventing phagocytosis and shaping immune responses. Beyond immunity, CD47 also influences cell death, growth and metabolism through interactions with integrins and thrombospondin-1. Recent studies implicate CD47 as a central nexus in the pathogenesis of diverse liver and gastrointestinal disorders, including metabolic dysfunction-associated steatotic liver disease, metabolic dysfunction-associated steatohepatitis, inflammatory bowel disease, liver ischaemia-reperfusion injury, drug-induced liver …

Gut Microbiome, Neuroinflammation, And Fetal Alcohol Spectrum Disorders: Insights From Rodent Models, Abdulrahman M. Busayli, Wenhua Xu, Ghaidaa A. Raffah, Gang Chen

Pharmacology and Nutritional Sciences Faculty Publications

Fetal alcohol spectrum disorder (FASD) is a significant public health issue that affects children. It results from ethanol exposure during pregnancy, leading to considerable physical, neurodevelopmental, behavioral, and cognitive deficits. The exact mechanism is not well understood. Recently, considerable attention has been focused on the influence of gut microbiome on brain development through the gut–brain axis. Changes in the gut microbiome resulting from ethanol exposure may contribute to the pathology of FASD, potentially involving neuroinflammation. This literature review summarizes the existing research and primary animal studies on the impact of early ethanol exposure on the gut microbiome, neuroinflammation, brain development, …

Calcineurin/Nfat Inhibitors Maintain Cognition In A Preclinical Prevention Study In An Aging Canine Model Of Alzheimer Disease, Lorena Sordo, Margo F. Ubele, Kathy Boaz, Jennifer L. Mefford, Erin Dehnart Jones, Katie L. Mccarty, Hollie Y. Van Rooyen, Jeffrey R. Smiley, Stasia A. Bembenek Bailey, Jessica A. Perpich, Beverly Meacham, David K. Powell, Frederick Bresch, Jacob W. Crump, Michael J. Phelan, Jessica A. Noche, Craig E. Stark, László G. Puskás, Christopher M. Norris, Elizabeth Head

Pharmacology and Nutritional Sciences Faculty Publications

Brain signaling of calcineurin (CN) and nuclear factor of activated T-cells (NFAT) transcription factor increases in Alzheimer disease (AD) and is associated with synaptic loss, neurodegeneration, neuroinflammation, amyloid-β (Aβ) production, and cognitive decline. CN/NFAT inhibitors ameliorate these neuropathologies in mouse models of AD. Further, chronic use of tacrolimus in transplant patients reduces risk of AD. Beagles naturally develop Aβ plaques and cognitive dysfunction. We evaluated the impact of FDA-approved CN inhibitor, tacrolimus, and experimental NFAT inhibitor, Q134R, on cognitive outcomes during a three-year prevention study in 37 middle-aged beagles. While beagles treated with CN/NFAT inhibitors showed differences in the pattern …

Ceramide Homeostasis In Hepatic Lipid Droplets, Leobarda Robles-Martinez, Kylie H. Morin, Mariana Nikolova‑Karakashian

Physiology Faculty Publications

Almost all eukaryotic cells have the capacity to form lipid droplets (LDs) in conditions of excess energy. Traditionally thought to be just inert fat reservoirs, LDs have recently emerged as important metabolic regulators of cellular stress response that buffer excess free fats and protect cells from lipotoxicity. Ceramide is a bioactive lipid that accumulates in metabolic tissues during fat oversupply. Emerging evidence suggests that sphingolipids and sphingolipid-metabolizing enzymes are found in the LDs and affect LD biogenesis and functions. This article aims to summarize the evidence, delineate some plausible functions of ceramide in hepatic LD biogenesis, and illustrate some of …

Native Bee Utilization Of Sorghum And Community Richness In Western Kansas Agricultural System, Katelyn M. Strack

Master's Theses or Doctor of Nursing Practice

In recent years, biologists have documented numerous threats facing native bee populations globally. Current agricultural practices have significant and often negative effects on native bee populations. It is imperative that we understand how these practices affect native bees. Sorghum (Sorghum bicolor (L.) Moench) is cultivated heavily in western Kansas as a grain crop. There is some evidence that native bees can utilize sorghum pollen in other systems. This study investigates whether native bees utilize pollen from sorghum and whether the presence of sorghum in the landscape influences the structure of native bee communities. We conducted observations of sorghum …

A Geometric Morphometrics Analysis Of The Limb Morphologies Of Mosasaurs And Its Palaeoecological Implications, Zachary J. Herbert

Master's Theses or Doctor of Nursing Practice

Mosasaurs were a major component of Late Cretaceous marine ecosystems, being the last Mesozoic radiation of secondarily aquatic tetrapods into diverse niches.

To shed light on the diversity and evolution of limb morphology in this clade, geometric morphometrics analyses were performed on seven skeletal elements from the forelimb and hindlimb. This study tested the hypothesis tested that mosasaurs living in similar environments would exhibit similar morphologies.

After analyzing datasets containing 29 taxa, the observed patterns did not support the hypothesis that habitat was the primary variable influencing morphology. The recurrence of a pattern, the plotting of plioplatecarpine mosasaurs closer to …

The Influence Of Anthropogenic Infrastructure On The Reproductive Success Of Northern House Wrens (Troglodytes Aedon) In Proximity To Highways, Nana-Esi Irie Hanson

Master's Theses or Doctor of Nursing Practice

Anthropogenic disturbances, particularly road infrastructure and noise pollution, significantly affect avian populations, influencing their ecology, behaviour, and reproductive success. This study examined the impact of highway proximity on the reproductive success of the Northern House Wrens (Troglodytes aedon) in a rural landscape. Noise levels and reproductive outcomes were compared between two sites in Hays, Kansas: a high-traffic site near Interstate 70 (Sternberg Museum Nature Trail) and a lower-traffic site at Big Creek on the Fort Hays State University campus. I hypothesized that increased traffic volume and noise pollution would negatively affect Northern House Wren reproductive success. Ambient noise …

Man With An Itchy Back, Katherine Schaffer, Nevin Adamski, Brittany Ambrose, Kathleen Anderson

Department of Emergency Medicine Faculty Publications

[First paragraph] A 61-year old man with no significant past medical history presented with painful bug bites on his lower back 1 day after a 1.5-week-long visit to Africa. He noticed bug bites on his lower back 3 days ago; since then, they have increased in size and become more painful. He was prescribed doxycycline at urgent care earlier that morning and had taken 1 dose. He is taking prophylactic medications for malaria and has had no fever at home. Vital signs, exquisitely tender papular lesions with a central punctum and surrounding erythema in the bilateral paralumbar regions.

A 40-Week Phase 2b Randomized, Multicenter, Double-Blind, Placebo-Controlled Study Evaluating The Safety And Efficacy Of Memantine In Amyotrophic Lateral Sclerosis, Salman Bhai, Todd Levine, Dan Moore, Robert Bowser, Andrew J. Heim, Maureen Walsh, Aziz Shibani, Zachary Simmons, James Grogan, Namita A. Goyal, Raghav Govindarajan, Yessar Hussain, Tania Papsdorf, Tiffany Schwasinger-Schmidt, Nick Olney, Kim Goslin, Michael Pulley, Edward J. Kasarskis, Michael Weiss, Susan W. Katz, Suzan Moser, Duaa Jabari, Omar Jawdat, Jeffrey Statland, Mazen M. Dimachkie, Richard Barohn, Neuromuscular Study Group And Western Als Consortium Memantine Als Study Group

Neurology Faculty Publications

Introduction: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease with no known cure, limited treatment options with minimal benefits, and significant unmet need for disease modifying therapies.

Aims: This study investigated memantine's impact on ALS progression, with an additional focus on the effects of memantine on cognitive and behavioral changes associated with the disease.

Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted from December 2018 to September 2020. ALS patients were enrolled in-person and remotely across 13 sites in the United States. Participants were randomized to memantine (20 mg twice daily) or placebo in a 2:1 ratio …