Psilocybin Prevents Symptoms Of Hyperarousal And Enhances Novel Object Recognition In Rats Exposed To The Single Prolonged Stress Paradigm,
2023
Ohio Northern University
Psilocybin Prevents Symptoms Of Hyperarousal And Enhances Novel Object Recognition In Rats Exposed To The Single Prolonged Stress Paradigm, Colin R. Del Valle, Heather R. Sparkman, Margaret M. Naylor, Connor M. Cruea, Rachel E. Rice, Claire E. Miller, Brooke E. Bramlage, Lillianna P. Puppel, Madison L. Brown, Aleece K. Al-Olimat, Elizabeth S. Dietz, Phillip R. Zoladz
ONU Student Research Colloquium
Pharmacotherapy for stress-related psychological disorders remains inadequate. Patients who are treated with conventional pharmacological agents frequently report negligeable symptom reduction, and, in most cases, less than 50% experience full remission. Clearly, there is a need for additional pharmaceutical research into both established and novel approaches to alleviate these conditions. Over the past several years, there has been a renewed interest in the use of psychedelics to aid in the treatment of psychological disorders. Several studies have reported promising results in patients with major depression, anxiety disorders, and post-traumatic stress disorder (PTSD) following treatment with psychedelic agents such as lysergic acid …
Tunnel Vision, False Memories, And Intrusive Memories Following Exposure To The Trier Social Stress Test,
2023
Ohio Northern University
Tunnel Vision, False Memories, And Intrusive Memories Following Exposure To The Trier Social Stress Test, Chloe N. Cordes, Cassidy L. Pfister, Kayla M. Boaz, Taylor D. Niese, Sydney L. Parker, Kristen E. Long, Mercedes L. Stanek, Matthew S. Risner, John G. Blasco, Koen N. Suzelis, Kelsey M. Siereveld, Shannon B. Carnes, Boyd R. Rorabaugh, Phillip R. Zoladz
ONU Student Research Colloquium
Most research examining the impact of stress on learning and memory has exposed participants to a stressor and measured how it affects learning and memory for unrelated material (e.g., list of words). Such work has been helpful, but it has not been the most translational to the human condition. When considering phenomena such as intrusive memories in post-traumatic stress disorder (PTSD) or an eyewitness's memory for a crime, it is most useful to know what an individual remembers about the stress experience itself, not unrelated information. In prior work, investigators used a modified version of the Trier Social Stress Test …
Impact Of Acute Stress, Sex, And Childhood Maltreatment On Fear Learning And Fear Generalization In A Fear-Potentiated Startle Paradigm,
2023
Ohio Northern University
Impact Of Acute Stress, Sex, And Childhood Maltreatment On Fear Learning And Fear Generalization In A Fear-Potentiated Startle Paradigm, Kayla M. Boaz, Chloe N. Cordes, Cassidy L. Pfister, Taylor D. Niese, Sydney L. Parker, Kristen E. Long, Mercedes L. Stanek, Boyd R. Rorabaugh, Seth D. Norrholm, Phillip R. Zoladz
ONU Student Research Colloquium
Many researchers approach the etiology of trauma-, stressor-, and anxiety-related mental disorders from the perspective of classical conditioning processes gone awry. According to this view, abnormal associative relationships between conditioned and unconditioned stimuli may underlie pathological anxiety and result in unusually intense fear memories or fear memories that cannot be properly extinguished. Recent work has expanded on this view by showing that many psychological disorders involving pathological anxiety are associated with an exaggerated form of stimulus generalization, leading individuals with such disorders to respond with fear and anxiety to a variety of contexts and cues that should not be threatening. …
Mechanisms Linking Threat- And Deprivation-Related Childhood Adversity And Depression: The Biopsychosocial Model,
2023
Behavioural Science Institue, Radboud University, The Netherlands; Faculty of Psychology, Universitas Indonesia
Mechanisms Linking Threat- And Deprivation-Related Childhood Adversity And Depression: The Biopsychosocial Model, Cut N. Kemala, Marijtje L.A. Jongsma, Donny Hendrawan, Eni Becker
Psychological Research on Urban Society
Childhood adversity involves a wide range of negative experiences that pose a serious threat to a child’s wellbeing. It has been consistently shown to predict (chronic) depression in subsequent stages of development, but mechanisms underlying the relationship are still less clear. Moving from a cumulative approach of lumping heterogeneous categories of childhood adversity to a dimensional approach of classifying negative experiences into two major dimensions (threat and deprivation) has facilitated the identification of specific processes by which childhood adversity can predict depression. This review aims to provide an integrative overview of how childhood adversity increases the risk for depression using …
Working Memory During The Menstrual Cycle: A Study Of The Role Of The Different Phases Of The Menstrual Cycle On Working Memory,
2023
Brescia University College
Working Memory During The Menstrual Cycle: A Study Of The Role Of The Different Phases Of The Menstrual Cycle On Working Memory, Daniella Brownrigg
Brescia Psychology Undergraduate Honours Theses
This study investigated the role of the menstrual cycle phases (Follicular, Luteal and Menstruation) on working memory components (verbal and visuospatial). Eighty-eight undergraduate students attending Brescia University college completed a survey regarding: demographics, menstrual cycle information and working memory cognitive tasks. The cognitive tasks were the Corsi Block Tapping Test and a shorter version of the Hooper Visual Organization test for visuospatial working memory; and the Forward Digit Span Test and the Semantic Verbal Fluency Subset: Animals from the Barcelona Test for verbal working memory. Participants were categorized into the different menstrual phases they were experiencing. No significant differences were …
Trait Sadism In Bdsm Practitioners And Non-Practitioners,
2023
University of New Mexico
Trait Sadism In Bdsm Practitioners And Non-Practitioners, Marley Russell
Psychology ETDs
Sadism is an elusive construct within psychology. Multiple types are studied without clear psychometric or theoretical distinctions, and operationalizations of these respective sub-constructs lack validity. This study explores the empirical distinction between two sadism types: consensual sexual sadism (i.e. in the context of BDSM) and trait sadism. Trait sadism is widely synonymized with “everyday sadism”, but here conceptualized as a higher-order construct encompassing both everyday and a novel “prosocial sadism”. I develop and pilot the BDSM Identities and Behaviors (BIB) checklist in a sample of BDSM practitioners. I then compare those practitioners to non-practitioners on trait sadism and dark triad …
Choline Supplementation Alters Hippocampal Cytokine Levels In Adolescence And Adulthood In An Animal Model Of Fetal Alcohol Spectrum Disorders,
2023
San Diego State University
Choline Supplementation Alters Hippocampal Cytokine Levels In Adolescence And Adulthood In An Animal Model Of Fetal Alcohol Spectrum Disorders, Jessica A. Baker, Tamara S. Bodnar, Kristen Breit, Joanne Weinberg, Jennifer D. Thomas
Psychology Faculty Publications
Alcohol (ethanol) exposure during pregnancy can adversely affect development, with long-lasting consequences that include neuroimmune, cognitive, and behavioral dysfunction. Alcohol-induced alterations in cytokine levels in the hippocampus may contribute to abnormal cognitive and behavioral outcomes in individuals with fetal alcohol spectrum disorders (FASD). Nutritional intervention with the essential nutrient choline can improve hippocampal-dependent behavioral impairments and may also influence neuroimmune function. Thus, we examined the effects of choline supplementation on hippocampal cytokine levels in adolescent and adult rats exposed to alcohol early in development. From postnatal day (PD) 4-9 (third trimester-equivalent), Sprague-Dawley rat pups received ethanol (5.25 g/kg/day) or sham …
"Alcohol Is Not Fun Anymore!": A Study Of Alcohol Expectancies During Covid-19,
2023
Northern Kentucky University
"Alcohol Is Not Fun Anymore!": A Study Of Alcohol Expectancies During Covid-19, Sara Mcfarland, Katie Ison, Heather Kissel Phd, Ty Brumback Phd
Posters-at-the-Capitol
College parties normalize alcohol use and students develop expectations about drinking due to peer influence and previous experience with alcohol. Our study investigated changes in alcohol expectancies by collecting cross-sectional data on predictors of alcohol use in young adults before and after the start of the pandemic. Data for 46 participants (mean age=20.74, 72% female) were collected prior to March 2020, while data for an additional 26 participants (mean age=19.27, 80.8% female) were collected starting in 2021. During the laboratory session, participants completed surveys and a structured clinical interview. We examined responses from the Alcohol Expectancy Questionnaire (AEQ). This self-report …
Is The Area Postrema Resistant To The Anesthetic Effects Of Ms-222?,
2023
Cal Poly Humboldt
Is The Area Postrema Resistant To The Anesthetic Effects Of Ms-222?, Austin T. Csiszar
Cal Poly Humboldt theses and projects
MS-222 is a common fish anesthetic that dampens neural activity by inhibiting neuronal voltage-gated sodium channels (Nav) required for action potentials. Previous experiments conducted by our lab’s primary investigator using fluorescence calcium imaging in zebrafish neurons resulted in the observation that neurons in the area postrema (AP), a circumventricular organ located in the dorsal hindbrain, displayed prominent fluorescence intensity during MS-222 induced sedation. I used the genetically encoded calcium indicator GCaMP6s to conduct fluorescence calcium imaging with the goal of recording neural activity in the larval zebrafish area postrema and optic tectum to compare the anesthetic effects of …
Effects Of Atomoxetine On Circadian Rhythms And Locomotor Activity,
2023
Cal Poly Humboldt
Effects Of Atomoxetine On Circadian Rhythms And Locomotor Activity, Rhiannon Ryder Crimmins
Cal Poly Humboldt theses and projects
Background: Attention deficit hyperactivity disorder (ADHD) is a common neurological disorder characterized by inattention, hyperactivity, and impulsive behavior. Many people with ADHD who are taking pharmacological treatments also report having sleep problems, and both children and adults tend to fall asleep later than neurotypical people. Since diagnosis and treatment of ADHD are on the rise, understanding how the disorder and common medications influence circadian rhythms is becoming more important. Zebrafish are a common animal model that have been shown to reliably represent features of many human disorders, including ADHD. Hypothesis: The specific hypotheses tested were: (H1) that a …
Individual Differences In The Coordinated Behavioral And Physiological Immune Response To Pathogenic Threat,
2023
Cal Poly Humboldt
Individual Differences In The Coordinated Behavioral And Physiological Immune Response To Pathogenic Threat, Edwin Joel Rosales-Vijil
Cal Poly Humboldt theses and projects
Previous research has shown that simply viewing a pathogenic threat (e.g., a photo of someone sneezing) can trigger our immune systems to activate. Activation of the immune system can be measured through a variety of physiological markers, including inflammatory cells (i.e., cytokines) in the blood or saliva. The current study aims to replicate that finding that viewing pathogen-relevant images will trigger an immune response, and extend this work by investigating whether individual differences in perceived vulnerability to disease impacts the size of this immune response.
Effects Of Development On Hpa Function Following Pubertal Stress,
2023
West Virginia University
Effects Of Development On Hpa Function Following Pubertal Stress, Brittany D. Elliott
Graduate Theses, Dissertations, and Problem Reports
For women, two of the greatest risk factors for affective disorders are adversity experienced during puberty and later becoming pregnant. We have created a translationally relevant mouse model where we address these complex risk factors. Previously, we discovered that pregnant mice (dams) that experienced chronic variable stress (CVS) during puberty display a blunted hypothalamic-pituitary-adrenal (HPA) response when exposed to an acute stressor. Interestingly, this alteration only first becomes apparent during pregnancy, which is a sensitive period for these effects due to normative neuroendocrine changes. Further investigation of the mechanisms underlying this dysfunction revealed altered gene expression in the paraventricular nucleus …
A Culturally Responsive Evaluation Lens To Logic Model Design,
2023
Claremont Colleges
A Culturally Responsive Evaluation Lens To Logic Model Design, Ciara Cascharelle Knight
CGU Theses & Dissertations
Culturally responsive evaluation (CRE) is an approach that centers all evaluation processes around the culture of a program’s secondary stakeholders. Specifically, this entails ensuring shared meanings in a group through communication. However, minimal connections have been made between CRE and logic model designs. Logic models commonly used by evaluators are data visualization and communication tools designed to aid in effectively communicating a program’s theory. Nevertheless, little is understood about the role culture plays in this process. This multiphase mixed methods study explored the integration of CRE to logic model designs using individualism and collectivism (IC) as a construct for culture …
Vapourized Cannabis Extract Administration Impairs Memory And Alters Neural Activity In Laboratory Rats,
2023
Wilfrid Laurier University
Vapourized Cannabis Extract Administration Impairs Memory And Alters Neural Activity In Laboratory Rats, Megan Chladny
Theses and Dissertations (Comprehensive)
Although people have smoked cannabis for millennia, administration of cannabis by heating the dried plant material or distilled extracts to a temperature just below the combustion point (i.e., vapourization or "vaping") has rapidly increased over the past few years (Javadi-Payder, Cole, and Taffe, 2018; Manwell, Charchoglyan, Brewer, Matthews, Heipel, and Mallet, 2014). Conversely, most of the cannabinoid research using rodent models has used parenteral routes of administration to examine the effects of purified cannabis extracts such as ∆9-tetrahydrocannabinol (THC), making it difficult to directly compare laboratory research to human drug use. Building on previous studies showing that THC …
Examining Allostatic Load As A Biological Mechanism Linking Childhood Adversity And Pediatric Pain,
2023
Virginia Commonwealth University
Examining Allostatic Load As A Biological Mechanism Linking Childhood Adversity And Pediatric Pain, Angela Pascale
Theses and Dissertations
Despite a strong literature base relating childhood adversity to pain, the biological mechanisms underlying these associations remain unclear. Theoretical and preliminary empirical evidence supports allostatic load as a potential biological mechanism, though prior studies investigating associations between childhood adversity and elevated allostatic load and/or between elevated allostatic load and poorer pain outcomes have primarily focused on adult populations and individual allostatic load indicators rather than a comprehensive index. Thus, the current study built upon prior literature by testing longitudinal relationships between childhood adversity and multiple biological indicators spanning across physiological systems (i.e., comprehensive allostatic load index) and pediatric pain outcomes …
The Feeling Of Control: The Psychology Behind Immersive Controls In Video Games And Their Real World Effects,
2023
Bard College
The Feeling Of Control: The Psychology Behind Immersive Controls In Video Games And Their Real World Effects, Atom Orbit Carrasco
Senior Projects Spring 2023
There is a phenomenon that can occur while playing video games where the player begins to feel similar sensations to the player character. This phenomenon, unnamed until now, has very little research directly related to it. There is plenty of indirect research that can be applied to this phenomenon, now called sensation mirroring. A review of both cognitive and psychobiological literature allows for major connections between human functions and how they interact with video game control schemes to be drawn. These connections help form a potential theory on the mechanisms of sensation mirroring and provide directions for future research on …
Preimplantation Genetic Testing For Neurobehavioral Traits,
2023
Cal Poly Humboldt
Preimplantation Genetic Testing For Neurobehavioral Traits, Peter K. Zeller
Cal Poly Humboldt theses and projects
Differences in behavioral and mental health traits result from unique interactions of genetic and environmental factors. Genetic information has improved along with technological advancements allowing for more data points to be established and increased data resolution. Because of this, there is a greater ability to identify embryos that carry genetic risk. The approach of Preimplantation Genetic Testing (PGT) is routine for certain genetic diseases but has not been widely used for psychiatric or behavioral traits. This paper critically examines the potential application of PGT-P by focusing on one main example, Alzheimer’s disease (AD). AD is the most prevalent form of …
Calcium Imaging Of Central Amygdala Activity After Fentanyl Escalation,
2023
University of Kentucky
Calcium Imaging Of Central Amygdala Activity After Fentanyl Escalation, Samantha Malone
Theses and Dissertations--Psychology
Evidence suggests that rats given long access (LgA) sessions to self-administer (SA) opioids escalate their intake, while also showing greater withdrawal severity and drug-induced reinstatement compared to rats maintained on short access (ShA) daily SA sessions. Little is known about the neural changes that occur during opioid escalation that may impact withdrawal and relapse. Past work examining opioid SA using ShA sessions in rodents has identified the central amygdala (CeA) as an area of interest that becomes hyperactive in acute withdrawal and may be involved in the incubation of craving that occurs after protracted withdrawal. However, these studies have not …
A Theoretical Basis For Understanding And Researching The Relationship Between Music, Stress, And Biofeedback,
2023
Antioch University Seattle
A Theoretical Basis For Understanding And Researching The Relationship Between Music, Stress, And Biofeedback, Frederick Wang
Antioch University Full-Text Dissertations & Theses
Music’s ability to influence emotional states and physical arousal has become an increasingly popular area of study. The wealth of literature around music and stress suggests a significant amount of interest in leveraging music to manage stress. However, as attention increases, the robustness of research becomes an increasing concern. This study investigates the current literature and proposes recommendations for the future studying of the psychological and physiological impacts of music as it relates to stress reduction. Existing literature was reviewed with a focus on the operationalization of key concepts of music and stress. The analysis showed considerable discrepancies in research …
Relation Between Parent Feeding And Emotional Overeating In Preschoolers As Mediated By Emotion Regulation,
2023
University of North Florida
Relation Between Parent Feeding And Emotional Overeating In Preschoolers As Mediated By Emotion Regulation, Lindsay Nicole Baker
UNF Graduate Theses and Dissertations
Emotional overeating is defined as eating in response to negative emotions, and the shift from emotional undereating to overeating around the preschool years indicates environmental influences. Parent feeding practices such as using food to regulate emotions and behavior may impede children’s ability to regulate their emotions, leading to emotional overeating. This study analyzed the relation between parent feeding practices, child emotion regulation, and emotional overeating in 4- and 5-year-old children. For study 1, mothers of 4- and 5-year-old children completed online questionnaires through MTurk and Prolific. Questionnaires measured parent feeding practices, emotion regulation, and emotional overeating. Parent use of food …
