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Dopamine D1 And D3 Receptor Polypharmacology In Cocaine Reward And Cocaine Seeking, Ewa J. Galaj 2017 The Graduate Center, City University of New York

Dopamine D1 And D3 Receptor Polypharmacology In Cocaine Reward And Cocaine Seeking, Ewa J. Galaj

All Graduate Works by Year: Dissertations, Theses, and Capstone Projects

Background: In the search for efficacious pharmacotherapies to treat cocaine addiction much attention has been given to agents targeting D1 or D3 receptors because of the involvement of these receptors in cocaine-related behaviors. D1 and D3 receptor partial agonists and antagonists have been shown to reduce cocaine reward, reinstatement of cocaine seeking and conditioned place preference (CPP) in rodents and non-human primates. However, translation of these encouraging results with selective D1 or D3 receptor agents has been limited due to a number of factors including toxicity, poor pharmacokinetic properties and extrapyramidal and sedative side effects.

Purpose: Given the role of ...


The Poverty Of The Neuroscience Of Poverty: Policy Payoff Or False Promise?, Amy L. Wax 2017 University of Pennsylvania Law School

The Poverty Of The Neuroscience Of Poverty: Policy Payoff Or False Promise?, Amy L. Wax

Faculty Scholarship

Research in deprivation neuroscience has grown rapidly over the past 15 years. Studies in this field examine brain structure and function of individuals from disadvantaged backgrounds. Many attempt to link brain characteristics to behavioral and cognitive deficits found more commonly in deprived populations.

The article assesses claims by neuroscientists and policy-oriented commentators that deprivation neuroscience can help generate more effective strategies for addressing poverty and deprivation. It concludes that research in this field has no unique practical payoff for reducing or alleviating poverty and its effects, over and above what is known or can be discovered from behavioral science and ...


The Importance Of Serotonergic And Adrenergic Receptors For The Induction And Expression Of One-Trial Cocaine-Induced Behavioral Sensitization, Krista N. Rudberg 2016 California State University - San Bernardino

The Importance Of Serotonergic And Adrenergic Receptors For The Induction And Expression Of One-Trial Cocaine-Induced Behavioral Sensitization, Krista N. Rudberg

Electronic Theses, Projects, and Dissertations

Addiction is a complex process in which behavioral sensitization may be an important component. While the behavioral effects of sensitization are well established, the intricate neurobiology of the phenomenon is still largely unknown. Dopamine systems mediate the induction of behavioral sensitization in adult rats, but there is a large amount of evidence showing that other neurotransmitter systems also modulate the induction process. For example, the α1b-adrenergic and 5-HT2A receptor systems are known to modulate the sensitized responding of adult rats, but the roles that these receptor systems play in the induction and expression of behavioral sensitization during the preweanling ...


Habitat Use By Bottlenose Dolphins, Tursiops Truncatus, In Roanoke Sound, North Carolina, Shauna Marisa McBride 2016 University of Southern Mississippi

Habitat Use By Bottlenose Dolphins, Tursiops Truncatus, In Roanoke Sound, North Carolina, Shauna Marisa Mcbride

Dissertations

Information on the habitat use of a species is important to develop conservation efforts and management strategies for that species. Roanoke Sound, North Carolina is primarily a seasonal habitat for bottlenose dolphins, Tursiops truncatus, from late spring to early fall, but little information is known about how dolphins use this area. Transect survey data and opportunistic survey data collected by the Outer Banks Center for Dolphin Research from 2009 to 2015 were used to analyze dolphin habitat use. The objectives of this project were to: 1) identify areas that were important to dolphins, 2) determine which behaviors were observed in ...


Marijuana Use Is Associated With Behavioral Approach And Depressive Symptoms In Adolescents And Emerging Adults, Natasha E. Wright, Danny Scerpella, Krista M. Lisdahl 2016 University of Wisconsin - Milwaukee

Marijuana Use Is Associated With Behavioral Approach And Depressive Symptoms In Adolescents And Emerging Adults, Natasha E. Wright, Danny Scerpella, Krista M. Lisdahl

Psychology Faculty Articles

Background

Repeated CB1 binding due to THC results in downregulation of the endocannabinoid system in cortex and limbic regions, perhaps disrupting frontolimbic functioning. This is particularly a concern in young adults who are still undergoing neurodevelopment in frontal and limbic regions. Such disruptions may be linked to increased depressive symptoms, anxiety symptoms, and executive dysfunction, and decreased behavioral approach.

Objectives

Here we examine the influence of young adult marijuana use on anxiety, depressive symptoms, behavioral approach, and executive dysfunction. The influence of alcohol and gender were also assessed.

Methods

84 participants (42 MJ, 42 controls) aged 18–25 were balanced ...


Using Auditory Feedback To Improve Striking For Mixed Martial Artists, Frank Krukauskas Krukauskas 2016 University of South Florida

Using Auditory Feedback To Improve Striking For Mixed Martial Artists, Frank Krukauskas Krukauskas

Graduate Theses and Dissertations

The purpose of this study was to evaluate, auditory feedback as a training procedure to increase the effectiveness of throwing a "right cross.” Auditory feedback was evaluated in multiple baselines across behaviors design with 4 mixed martial arts students, two males and two females, 25-54 years old. The percentage of correct steps of the right crosses.” was stable .during baseline for all participants improved substantially following the introduction of the auditory feedback, and maintained at 90 percent or more for all participants during follow-up.


Connecting Psychopathology Meta-Structure And Mechanisms, Charles A. Sanislow 2016 Wesleyan University

Connecting Psychopathology Meta-Structure And Mechanisms, Charles A. Sanislow

Charles A. Sanislow

No abstract provided.


Collaboration Guidelines To Transform Culture, Benjamin Heslop, Kylie Bailey, Jonathan Paul, Antony Drew, Roger Smith 2016 University of Newcastle

Collaboration Guidelines To Transform Culture, Benjamin Heslop, Kylie Bailey, Jonathan Paul, Antony Drew, Roger Smith

Interdisciplinary Journal of Partnership Studies

Positive-sum behaviour arises when people expect a benefit from cooperation. This article argues that positive-sum behaviours give rise to a fairer, more civilized society; however, adoption of these behaviours is impeded by their complexity. For example, others’ actions may seem unpredictable, while individual benefit may seem intangible. Consequently, adoption of positive-sum behaviours could be encouraged by explicit instructions. This article proposes guidelines and outcomes for healthy collaboration, which is a positive-sum behaviour.


The Effect Of Increased Sleep On The Circadian Rhythm Of Salivary Cortisol Concentrations, Mariah Jacqueline Scott 2016 Seton Hall University

The Effect Of Increased Sleep On The Circadian Rhythm Of Salivary Cortisol Concentrations, Mariah Jacqueline Scott

Seton Hall University Dissertations and Theses (ETDs)

Cortisol is a salivary marker for the hypothalamic-pituitary-adrenal axis (HPA) component of the stress response. The activity of the HPA demonstrates a circadian rhythm. It is well known that sleep deprivation increases cortisol concentrations. In this study, we looked at the effect of an increase of one-hour sleep for one month on the circadian rhythm of the HPA.

Eight college subjects (n=8) collected saliva during their normal sleep wake cycle every 4 hours for 24 hours. Saliva collections were repeated after a month of increase of sleep by 1-hour. The subjects also completed demographic forms that asked for age ...


Updating The Research Domain Criteria, Charles A. Sanislow 2016 Wesleyan University

Updating The Research Domain Criteria, Charles A. Sanislow

Charles A. Sanislow

No abstract provided.


Observational Assessment Of Empathy In Parent-Child Verbal Exchanges And Their Influence On Child Behavior, Patty Carambot 2016 The Graduate Center, City University of New York

Observational Assessment Of Empathy In Parent-Child Verbal Exchanges And Their Influence On Child Behavior, Patty Carambot

All Graduate Works by Year: Dissertations, Theses, and Capstone Projects

Empathy, the ability to both experientially share in and understand others’ thoughts, behaviors, and feelings, is vital for human adaptation. Deficits in empathy development have implications across the lifespan for the development of prosocial behavior, social functioning, mental health disorders, and risk for antisocial behavior (e.g., Guajardo, Snyder, & Petersen, 2009; Moreno, Klute & Robinson, 2008). In light of these societal and individual burdens, it is imperative to foster and strengthen the development of this ability early in life to prevent or ameliorate such negative outcomes. This type of prevention can take a variety of forms, but parent and child verbal exchanges and modeling are often the most direct methods after two years of age (e.g., Moreno et al., 2008). The aim of this research was to inform the development of a system to naturalistically assess empathy development via home-based observation of mothers and their children’s verbal exchanges.

The proposed system, iEAR-Empathy in Parent-Child Interactions (iEAR-EPIC), is a verbal coding system to code for verbal behaviors empirically demonstrated to foster empathy development, as well as behaviors found to indicate empathy development. The development of the iEPIC was theoretically informed by Preston and de Waal’s (2002) Perception Action Mechanism (PAM) model of empathy, a neurocognitive-emotional model of empathy. This model demonstrates empathy as a maturing system in which emotional and cognitive understanding develop in tandem through brain-environment interactions. However, the iEPIC also accounts for the interplay between parents and neurocognitive emotional processes, and thus captures the parallel, increasingly interactive, development of cognitive and emotional abilities from infancy onward in the context of a parent-child dyad.

To develop and test the iEPIC, an ethnically diverse subsample of 84 mothers and their 2 to 6-year-old children were recruited from a large, northeastern, urban, public university. After consenting, mother-child dyads were recorded for a 4-hour period during the dyad’s evening routine (5-9p.m.), using a two-minutes on, 10 seconds off protocol, resulting in 28 2-minute clips (56 minutes total) per dyad. Recordings were transcribed and reviewed, and then 4 pairs of coders were trained in the iEPIC coding system, and then coded the dyad recordings for behaviors comprising the proposed iEPIC assessment system.

The iEPIC observational assessment system consists of 5 codes for each parent and child: Reflection (R), Exploring Emotion and State (EES), Emotion and State Description (ESD), and Empathic Understanding and Concern (EUC), as well as Neutral verbalizations (N; non-study-related verbalizations). The EES, ESD, and EUC each have levels of complexity, with higher levels expected to occur more frequently in older children (e.g., 4 years and older).

There were several purposes of the current study: 1) assess inter-rater reliability for the iEPIC coding system 2) determine if ...


Ptsd From Childhood Trauma As A Precursor To Attachment Issues, Christy Owen 2016 Counseling

Ptsd From Childhood Trauma As A Precursor To Attachment Issues, Christy Owen

Fidei et Veritatis: The Liberty University Journal of Graduate Research

The past 20 years have been turbulent regarding Reactive Attachment Disorder (RAD), with conflicting research about its causes, effects, treatment, and prognosis. The current diagnostic criteria in the DSM-5 fails to adequately address this disorder. A number of deviant and maladaptive behaviors common amongst children with RAD are not even mentioned in the diagnostic criteria. As such, the diagnostic definition is almost unidentifiable or incompatible with real-life conduct manifestations of the disorder. Rather, this author contends that RAD is foundationally a unique and extreme form of Posttraumatic Stress Disorder (PTSD) from Early Childhood Trauma. The child endured unspeakable neglect and ...


The Bilingual Brain, Victoria A. James 2016 Gardner-Webb University

The Bilingual Brain, Victoria A. James

Journal of Counseling and Psychology

This literature review explores the neurocognitive effects of the bilingual brain. Many areas of bilingualism are examined such as age of acquisition, which is when the second language is attained, and memory. The three types of bilingual memory are implicit memory, which is procedural memory, explicit memory, which is declarative memory, and episodic memory, which is autobiographical memory. In relation to the bilingual brain, cognition, control, and /lateralization are also reviewed. Finally, second language (L2) learning strategies are considered. The objective of this study is to obtain an understanding on how two or more languages are acquired and processed in ...


Reactivity And Recovery Among Oif/Oef/Ond Combat Veterans: Do Those With Subthreshold Ptsd Differ From Veterans With And Without Ptsd?, Paula Castro-Chapman 2016 University of South Florida

Reactivity And Recovery Among Oif/Oef/Ond Combat Veterans: Do Those With Subthreshold Ptsd Differ From Veterans With And Without Ptsd?, Paula Castro-Chapman

Graduate Theses and Dissertations

This study expanded the current literature by assessing PTSD in relation to reactivity and recovery from negative emotional arousal among OEF/OIF/OND Veterans. Cardiac impedance was employed during a speech task and a trauma imagery procedure. Those in the PTSD-S group displayed lower SBP and higher TPR reactivity relative to the PTSD- and PTSD+ groups; lower CO reactivity relative to the PTSD+ group; and more CO recovery than those in the PTSD+ group to the trauma task. For speech task, Veterans in the PTSD-S group exhibited lower HR reactivity for both speech preparation and delivery than those in the ...


Neural Mechanisms Of Action Switching Moderate The Relationship Between Effortful Control And Aggression, Eric L. Rawls, Connie Lamm 2016 University of New Orleans

Neural Mechanisms Of Action Switching Moderate The Relationship Between Effortful Control And Aggression, Eric L. Rawls, Connie Lamm

University of New Orleans Theses and Dissertations

Aggression and violence are social behaviors that exact a significant toll on human societies. Individuals with aggressive tendencies display deficits in effortful control, particularly in affectively charged situations. However, not all individuals with poor effortful control are aggressive. This study uses event-related potentials (ERPs) to decompose the chronology of cognitive functions underlying the link between effortful control and aggression. Specifically, this study investigates which ERPs moderate the effortful control - aggression association. We examined three successive ERP components (P2, N2 and P3) for stimuli that required effortful control. Results indicated that N2 activation, but not P2 or P3 activation, moderated the ...


Investigating The Role Of Testosterone Signaling At Androgen Receptors In Resiliency To Social Stress, Catherine Tucker Clinard 2016 University of Tennessee, Knoxville

Investigating The Role Of Testosterone Signaling At Androgen Receptors In Resiliency To Social Stress, Catherine Tucker Clinard

Doctoral Dissertations

Social experience can alter how individuals cope with stressful events and contribute to individual differences in stress vulnerability. We have previously tested dominant and subordinate male Syrian hamsters (Mesocricetus auratus) in a conditioned defeat model and found that dominant individuals show reduced defeat-induced changes in behavior compared to subordinates. Dominant hamsters also show increased neural activation following social defeat stress in brain regions that regulate social behavior and coping with stress, including the medial amygdala (MeA). Because winning aggressive encounters generates a surge in plasma testosterone and androgen receptors are abundant in the MeA, we tested whether testosterone signaling at ...


Therapy Dogs In The College Classroom: The Effect Of Dogs On Stress, Anxiety, And Spanish L2 Phonological Learning And Performance, Elaine Maralee Henry 2016 University of Tennessee, Knoxville

Therapy Dogs In The College Classroom: The Effect Of Dogs On Stress, Anxiety, And Spanish L2 Phonological Learning And Performance, Elaine Maralee Henry

Doctoral Dissertations

Anxiety and stress invoked by the second language classroom setting has the ability to cause numerous detrimental physiological changes which impair the learning process. A more natural, “immersion” type atmosphere is often desired when teaching a second language; however, this is not typically possible with college classes. Therefore, the addition of therapy dogs to college second language classes may be a beneficial solution since therapy dogs are frequently cited as having the ability to lower stress and anxiety in many different settings. Stroking and interacting with a dog may reduce many markers of stress, including blood pressure, heart rate, and ...


Perseverance: Psychospiritual And Genetic Perspectives, Tony N. Jelsma, Arielle Johnston, Bruce Vermeer 2016 Dordt College

Perseverance: Psychospiritual And Genetic Perspectives, Tony N. Jelsma, Arielle Johnston, Bruce Vermeer

Faculty Work: Comprehensive List

Perseverance constitutes a quality that motivates humankind to press onward usually in the face of significant adversity and resistance. Perseverance is also important in the Christian life. The apostle Paul, using athletic training metaphors, frequently urges his readers to persevere in the faith, even describing his own life as a fight and a race (2 Tim.4:7). Yet, certain groups of people seem to possess a greater measure of perseverance than others have. We are therefore led to ask, “Can our ability to persevere be, in God’s providence, at least partly genetically influenced?”


Nicotine And Methylphenidate Chornic Exposure On Adult Cannabinoid Receptor Agonist (Cp 55,940) Place Conditioning In Male Rats, Christopher P. Plant 2016 California State University - San Bernardino

Nicotine And Methylphenidate Chornic Exposure On Adult Cannabinoid Receptor Agonist (Cp 55,940) Place Conditioning In Male Rats, Christopher P. Plant

Electronic Theses, Projects, and Dissertations

A problematic connection has been reported between those who use nicotine related products alone or in combination with ADHD medications, like methylphenidate (MPH), in late childhood or early adolescence and the increased likelihood of later marijuana abuse in adulthood. Pre-clinical studies have found that the use of nicotine during the early adolescence period produces enduring changes to the endocannabinoid system in the brain. Since CB agonists, like marijuana, exert their effect through the eCB system, it is possible that early nicotine use may alter the rewarding nature of CB agonists in adulthood. In addition, MPH has also been shown to ...


Importance Of The D2 Receptor For One- And Multi-Trial Psychostimulant-Induced Behavioral Sensitization In Preweanling Rats, Martha A. Mohd-Yusof 2016 California State University - San Bernardino

Importance Of The D2 Receptor For One- And Multi-Trial Psychostimulant-Induced Behavioral Sensitization In Preweanling Rats, Martha A. Mohd-Yusof

Electronic Theses, Projects, and Dissertations

The neural mechanisms mediating one-trial and multi-trial behavioral sensitization during early ontogeny are poorly understood. The purpose of this thesis was to assess the importance of D2-like receptors for the induction of cocaine- and methamphetamine-induced one-trial and multi-trial behavioral sensitization during the middle and late preweanling period. In a series of four experiments, rats were injected with saline or the selective dopamine D2-like receptor antagonist raclopride 15 min prior to treatment with the indirect dopamine agonists cocaine or methamphetamine. Acute control groups received two injections of saline. The pretreatment regimens occurred on either PND 16 or PND 20 (one-trial behavioral ...


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