A True Bloody Emergency: An Unusual Case Of Thrombotic Thrombocytopenic Purpura, 2024 The University of Texas Rio Grande Valley
A True Bloody Emergency: An Unusual Case Of Thrombotic Thrombocytopenic Purpura, Joshua M. Ninan
Research Symposium
Background: Thrombotic thrombocytopenic purpura (TTP) is a primary thrombotic microangiopathy that is classically characterized by thrombocytopenia and microangiopathic hemolytic anemia (MAHA). Although rare with an annual incidence of 3.7 cases per one million adults, it is considered a true hematological emergency due to its fatality rate of almost 100% if appropriate treatment is not initiated immediately. This makes it vitally important to identify and treat patients with TTP, a task that becomes unusually challenging in the absence of the disorder’s other characteristically diagnostic clinical features such as mucosal bleeding, fever, or presence of schistocytes.
Case Presentation: A 30-year-old gentleman with …
Stigma And Patient-Controlled Analgesia: Trust Is The Essential Ingredient Of Successful Patient Education In The Patient-Doctor Relationship, 2023 Wayne State University
Stigma And Patient-Controlled Analgesia: Trust Is The Essential Ingredient Of Successful Patient Education In The Patient-Doctor Relationship, Trey D. Vanaken
Clinical Research in Practice: The Journal of Team Hippocrates
A clinical decision report using:
Van Beers EJ, Van Tuijn CFJ, Nieuwkerk PT, et al. Patient-controlled analgesia versus continuous infusion of morphine during vaso-occlusive crisis in sickle cell disease, a randomized controlled trial. Am J Hematol. 2007;82(11):955-960. https://doi.org/10.1002/ajh.20944.
for a patient with recurrent vaso-occlusive crisis secondary to Sickle Cell Disease.
Hepatitis B Virus And B-Cell Lymphoma: Evidence, Unmet Need, Clinical Impact, And Opportunities, 2023 Thomas Jefferson University
Hepatitis B Virus And B-Cell Lymphoma: Evidence, Unmet Need, Clinical Impact, And Opportunities, Maya Rosenberg, Maria Poluch, Colin Thomas, Paola Sindaco, Alan Khoo, Pierluigi Porcu
Kimmel Cancer Center Faculty Papers
Nearly a billion people worldwide are infected with the hepatitis B Virus (HBV) and about a third of them have chronic infection. HBV is an important cause of morbidity and mortality, including acute and chronic hepatitis and hepatocellular carcinoma (HCC). Screening and control of primary HBV infection through vaccination represent a major advance in global public health, but large sections of the world population, in both developed and underdeveloped countries, remain unscreened and unvaccinated. In addition to being a global cause of liver disease, an important role of HBV in lymphoma has also emerged. First, the high risk of HBV …
Investigating The Role Of Il-10 Producing Nkt Cells In Prevention Of Graft Versus Host Disease, 2023 The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences
Investigating The Role Of Il-10 Producing Nkt Cells In Prevention Of Graft Versus Host Disease, Drew Boagni
Dissertations & Theses (Open Access)
The standard curative treatment for hematologic malignancies is allogeneic stem cell transplantation (ASCT), in which the patient’s immune system is replaced with that of a healthy donor. This can lead to cure through the graft versus leukemia (GVL) effect but can also cause graft versus host disease (GVHD), which is characterized by systemic inflammation and organ damage mediated by dysregulated donor T cells. Preclinical studies have shown invariant natural killer T cells (iNKT) cells can prevent GVHD while preserving GVL. iNKT cells are unconventional T cells which recognize glycolipid antigens presented in the context of CD1d. Upon activation, they secrete …
Relative Reticulocytopenia, Erythropoietin, And Kidney Function In Patients With Sickle Cell Disease, 2023 St. Christopher's Hospital for Children
Relative Reticulocytopenia, Erythropoietin, And Kidney Function In Patients With Sickle Cell Disease, Richard Suarez, Nataly Apollonsky, Bruce Bernstein
St. Chris Research Day
No abstract provided.
A Rare Case Of Rapidly Progressive Cll/Sll Presenting As Bilateral Tonsillar Enlargement And Upper Airway Obstruction, 2023 HCA Healthcare
A Rare Case Of Rapidly Progressive Cll/Sll Presenting As Bilateral Tonsillar Enlargement And Upper Airway Obstruction, William Mangin, Kashif Aslam
North Texas Research Forum 2023
Although chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) differ in clinical presentation, they are both arise from the same pathologic process, namely the clonal expansion of mature B-cells. This malignancy is usually quite indolent and carries a favorable prognosis. Thanks to a number of highly-effective oral targeted therapies, such as the Bruton tyrosine kinase (BTK) inhibitor, Ibrutinib, patient outcomes have improved significantly. Unfortunately, these therapies are not always well tolerated and many patients are forced to discontinue the medication due to side effects. Many patients experience a disease flair and some even transformation to a high-grade malignancy after …
Covid-19 Masking An Atypical Presentation Of Hairy Cell Leukemia, 2023 HCA Healthcare
Covid-19 Masking An Atypical Presentation Of Hairy Cell Leukemia, Kahmalia-Kalee Sada
North Texas Research Forum 2023
Hairy cell leukemia is a rare lymphoid neoplasm of small mature B cell lymphoid cells. Hairy cell leukemia only accounts for about 1 to 2 percent of adult leukemia cases. Early diagnosis of Hairy cell Leukemia is important, it is proven that without treatment the median survival of this cancer is four years. After numerous studies the age-adjusted risk of death with proper diagnosis and treatment has decreased by 85%. The greatest outcomes are seen in individuals who are younger with earlier diagnosis. Hairy Cell Leukemia is a rare leukemia seen with the classic triad of splenomegaly, pancytopenia, and “hairy” …
Acute Thalamic Stroke In A Covid Positive Adult: A Case Report, 2023 HCA Healthcare
Acute Thalamic Stroke In A Covid Positive Adult: A Case Report, Norberto Escobales, Daniel Kiehl, Michelle Militello, Aleger Vorbes
South Atlantic Division Research Day 2023
No abstract provided.
A Case Of Type 1 Cryoglobulinemia With Waldenstrom’S Macroglobulinemia/Lymphoplasmocytic Lymphoma And Dry Gangrene, 2023 HCA Healthcare
A Case Of Type 1 Cryoglobulinemia With Waldenstrom’S Macroglobulinemia/Lymphoplasmocytic Lymphoma And Dry Gangrene, Abhinav Rao, Diego Garrido, Fahim Syed, Kody Dhaliwal, Charles Holladay, Julia Saylors, Matthew Madden, Jason Clark
South Atlantic Division Research Day 2023
No abstract provided.
Hemoglobinopathy Is Associated With Total Hip Arthroplasty Indication Even Beyond Sickle Cell Anemia, 2023 University of Kentucky
Hemoglobinopathy Is Associated With Total Hip Arthroplasty Indication Even Beyond Sickle Cell Anemia, Maxwell J. Rakutt, Daniel N. Bracey, Anna Cohen-Rosenblum, Peter K. Sculco, Franco M. Sabatini, Cale A. Jacobs, Stephen T. Duncan, David C. Landy
School of Medicine Faculty Publications
Background: The extent to which hemoglobinopathies other than sickle anemia (HbSS) are associated with hip osteonecrosis is unknown. Sickle cell trait (HbS), hemoglobin SC (HbSC), and sickle/β-thalassemia (HbSβTh) may also predispose to osteonecrosis of the femoral head (ONFH). We sought to compare the distributions of indications for a total hip arthroplasty (THA) in patients with and without specific hemoglobinopathies. Methods: PearlDiver, an administrative claims database, was used to identify 384,401 patients aged 18 years or older undergoing a THA not for fracture from 2010 to 2020, with patients grouped by diagnosis code (HbSS N = 210, HbSC N = 196, …
Does The Osteopathic Pedal Pump Reduce Lower Limb Volume In Healthy Subjects?, 2023 Rowan University
Does The Osteopathic Pedal Pump Reduce Lower Limb Volume In Healthy Subjects?, Jill S. Adams, Sahil H. Parikh, Brandon J. Goodwin, Donald R. Noll
Rowan-Virtua School of Osteopathic Medicine Faculty Scholarship
CONTEXT: Lymphatic treatments are gentle and passive techniques believed to enhance movement of lymph back into the central circulatory system. Animal studies provide supportive evidence, yet there are few studies in humans.
OBJECTIVES: The aim of this study is to investigate whether the osteopathic pedal pump protocol reduces volume in the lower limbs of healthy subjects.
METHODS: A total of 30 first- and second-year medical students were recruited. Subjects were excluded from participating if they had acute asthma, chronic obstructive pulmonary disease (COPD), congestive heart failure, active infections, fractures of the lower extremities, or metastatic cancer. A within-subjects study design …
Clinical Utility Of Neutrophil To Lymphocyte Ratio In Sickle Cell Disease With Vaso-Occlusive Crisis, 2023 Hematology & Oncology, Internal Medicine, Texas Tech University
Clinical Utility Of Neutrophil To Lymphocyte Ratio In Sickle Cell Disease With Vaso-Occlusive Crisis, Satish Maharaj, Simone Chang
Hematology/Oncology and Stem Cell Therapy
Background and objectives: The neutrophil-to-lymphocyte ratio represents a universally accessible value that correlates with inflammation and prognosis in several disease states; however, the role of this biomarker in sickle cell disease remains poorly explored. Hence, the objective of the present study was to determine its potential clinical utility in patients with sickle cell disease.
Patients: Herein, we retrospectively reviewed 143 patients with sickle cell disease who presented to the emergency department with fever and painful vaso-occlusive crisis.
Results: The examined cohort had a prevalence of 11% confirmed bacterial infection, with approximately two-thirds reporting the use of hydroxyurea. The neutrophil-to-lymphocyte ratio …
Kikuchi Disease: A Rare Recurrence, 2023 HCA Healthcare
Kikuchi Disease: A Rare Recurrence, R Levi Sundermeyer, Jessica Bautista
Continental, MidAmerica, & Mountain Divisions Research Day 2023
No abstract provided.
Multiple Myeloma Diagnosed In A 23-Year-Old Male Presenting With Pathologic Compression Fracture, 2023 HCA Healthcare
Multiple Myeloma Diagnosed In A 23-Year-Old Male Presenting With Pathologic Compression Fracture, Kyle Combe, Tristan Myers, Michelle Levy, Greg Schlessinger
Continental, MidAmerica, & Mountain Divisions Research Day 2023
No abstract provided.
Unusual Presentation Of B-Cell Acute Lymphocytic Leukemia (All) With Skin Manifestations, 2023 HCA Healthcare
Unusual Presentation Of B-Cell Acute Lymphocytic Leukemia (All) With Skin Manifestations, Muhammad Bilal, Victoria Brown, Uma Iyer
North Florida Division Research Day 2023
No abstract provided.
A Case Of Amiodarone Induced Thyrotoxicosis Presenting With Methimazole Induced Agranulocytosis, 2023 HCA Healthcare
A Case Of Amiodarone Induced Thyrotoxicosis Presenting With Methimazole Induced Agranulocytosis, Suhail Saadomer, Moises Matos, Mustafa Kinaan
North Florida Division Research Day 2023
No abstract provided.
Paraneoplastic Leukemoid Reaction In Uterus Carcinosarcoma, 2023 HCA Healthcare
Paraneoplastic Leukemoid Reaction In Uterus Carcinosarcoma, Xiaolan Tang, Ashali Jain, Uma Iyer, Jennifer Reppucci
North Florida Division Research Day 2023
No abstract provided.
Spur Cell Hemolytic Anemia: An Uncommon Etiology Of Anemia In Liver Cirrhosis, 2023 HCA Healthcare
Spur Cell Hemolytic Anemia: An Uncommon Etiology Of Anemia In Liver Cirrhosis, Hanan Gruhonjic, Austin Van Vliet, Maxwell Tague, Masi Javeed
West Florida Division Research Day 2023
No abstract provided.
A Case Of Suspected Intracranial Granulocytic Sarcomas Versus Cerebrovascular Hemorrhage In A Young Male With Cml With Aml Transformation, 2023 HCA Healthcare
A Case Of Suspected Intracranial Granulocytic Sarcomas Versus Cerebrovascular Hemorrhage In A Young Male With Cml With Aml Transformation, Nicholas C. Rochester, Alicia C. Mccartney, Amol S. Patel, Alexandra Kroes, Angelina Rodriguez, Napatkamon Ayutyanont, Upinder Singh
Far West Division Research Day 2023
No abstract provided.
Follicular Lymphoma Presenting As A Small Bowel Obstruction: A Case Report, 2023 HCA Healthcare
Follicular Lymphoma Presenting As A Small Bowel Obstruction: A Case Report, Erica Roma, Kelsey Staudinger, Emmett Mcguire, Katrina Lancaster Shorts
Continental, MidAmerica, & Mountain Divisions Research Day 2023
No abstract provided.