Nervous System Diseases Commons^™

Impact Of Insurance Status On Migraine Care In The United States, Andrew Wilper, Steffie Woolhandler, David U. Himmelstein, Rachel Nardin

Publications and Research

Objective
To determine whether insurance status is associated with differential outpatient treatment of migraine in the United States.

Methods
We analyzed 11 years of data from the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey (1997–2007), which survey patient visits to doctors’ offices, hospital outpatient departments, and emergency departments (EDs) in the United States. We used logistic regression to determine whether insurance status was associated with the prescription of standard migraine therapy, defined as 1) a triptan or dihydroergotamine and 2) a prophylactic agent.

Results
We identified 6,814 individual patient visits for migraine, representing 68.6 million …

Band Heterotopia, M. S. Alam, N Naila

Section of Internal Medicine

Band heterotopias are one of the rarest groups of congenital disorder that result in variable degree of structural abnormality of brain parenchyma. Band of heterotopic neurons result from a congenital or acquired deficiency of the neuronal migration. MRI is the examination of choice for demonstrating these abnormalities because of the superb gray vs. white matter differentiation, detail of cortical anatomy and ease of multiplanar imaging. We report a case of band heterotopia that showed a bilateral band of gray matter in deep white matter best demonstrated on T2 Wt. and FLAIR images.

Growing Burden Of Neurological Diseases In Pakistan � Need For A National Health Survey, Mohammad Wasay, Shaukat Ali

Department of Medicine

No abstract provided.

Good-Bye, Pre-Existing Conditions!, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Aiming For Hd Clinical Trials, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

A Restless Soul At The Hd Research Meeting, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

A Super Sunday Hd Story, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Telling The Truth About A Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

When The Pain Brings A Smile, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Squeezing In The Life, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Finding The Pill On The Floor: How Contrast Sensitivity Affects Daily Living Skills In Alzheimer’S Disease Patients, Marlyn Colon

Undergraduate Review

Alzheimer’s disease (AD) is a progressive brain disorder that gradually destroys an individual’s mental functioning and social capabilities, including the ability to carry out everyday activities. Although memory deficits affect AD patients’ ability to perform these activities, research suggests that visual perception impairments also contribute. One impaired visual perception ability, contrast sensitivity, enables one to distinguish an object from its immediate surroundings. The present project measured contrast sensitivity in a real-world task by having AD patients find a pill of various shades of gray on a tiled background. Results were compared to young and elderly control participants. Participants also filled …

Genetic Connections Between Neurological Disorders And Cholesterol Metabolism, Ingemar Bjorkhem, Valerio Leoni, Steve Meaney

Articles

Cholesterol is an essential component of both the peripheral and central nervous systems of mammals. Over the last decade, evidence has accumulated that disturbances in cholesterol metabolism are associated with the development of various neurological conditions. In addition to genetically defined defects in cholesterol synthesis, which will be covered in another review in this Thematic Series, defects in cholesterol metabolism (cerebrotendinous xanthomatosis) and intracellular transport (Niemann Pick Syndrome) lead to neurological disease. A subform of hereditary spastic paresis (type SPG5) and Huntington's disease are neurological diseases with mutations in genes that are of importance for cholesterol metabolism. Neurodegeneration is generally …

Disclosure Of At-Risk Status For Huntington's Disease: Is There A "Right Time?", Krysten Ann Shipley

Honors Program Theses

The disclosure of at-risk status for HD can be a complicated and stress inducing process. The most difficult people to disclose this information to are most often those who are also at-risk, notably the children of individuals who are themselves at-risk for developing the disease or know that they will develop the disease. How and when a child finds out that he or she is at risk for a debilitating disease can have a tremendous impact on the development of the child. The purpose of this thesis is to assess the ideal course of action in dealing with how and …

An Epitope From Acanthamoeba Castellanii That Cross-React With Proteolipid Protein 139-151-Reactive T Cells Induces Autoimmune Encephalomyelitis In Sjl Mice, Chandirasegaran Massilamany, David Steffan, Jay Reddy

Jay Reddy Publications

We report here that an epitope (aa, 83-95) derived from Acanthamoeba castellanii (ACA) induces clinical signs of experimental autoimmune encephalomyelitis (EAE) in SJL/J mice reminiscent of the disease induced with myelin proteolipid protein (PLP) 139-151. By using IA^s/tetramers, we demonstrate that both ACA 83-95 and PLP 139-151 generate antigen-specific cross-reactive CD4 T cells and the T cells secrete identical patterns of cytokines and induce EAE with a similar severity. These results may provide insights into the pathogenesis of multiple sclerosis and ACA-induced granulomatous encephalitis.

Ischemic Stroke Care - Official Guidelines From The Pakistan Society Of Neurology, Ayeesha Kamran Kamal, Ahmed Itrat, Imama Naqvi, Maria Khan, Roomasa Channa, Ismail Khatri, Mohammad Wasay

Department of Medicine

No abstract provided.