Superterry Destroys The Evil Monster Huntington’S Disease,
2012
University of San Diego
Superterry Destroys The Evil Monster Huntington’S Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Playing In The Fourth Quarter Of Life As Huntington's Disease Looms,
2012
University of San Diego
Playing In The Fourth Quarter Of Life As Huntington's Disease Looms, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
California Stem Cell Agency Approves $19 Million Clinical Trial Project As Huntington's Disease Families 'Change The Course Of Science',
2012
University of San Diego
California Stem Cell Agency Approves $19 Million Clinical Trial Project As Huntington's Disease Families 'Change The Course Of Science', Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Exogenous Alpha-Synuclein Induces Cell Death Related Proteins In C6 Oligodendrocyte-Like Cells Corresponding To Protein Expression Observed In Multiple System Atrophy,
2012
Western Michigan University
Exogenous Alpha-Synuclein Induces Cell Death Related Proteins In C6 Oligodendrocyte-Like Cells Corresponding To Protein Expression Observed In Multiple System Atrophy, Derrick Samuel Hilton
Dissertations
Multiple System Atrophy (MSA) consists of three disorders; Autonomic Dysfunction, Cerebellar Ataxia, and Parkinsonism. In MSA, the protein Alpha-Synuclein (SNCA) appears in the central nervous system as misfolded protein aggregates primarily in oligodendrocytes. This dissertation reports the results from studies examining the effect of exogenous SNCA has on a cell model: C6 oligodendrocyte-like cells. Treated cells were evaluated using western blot and DNA microarray. In addition the expression of proteins was evaluated using immunocytochemistry in MSA patient tissue.
C6 cells were shown to take up SNCA when added to the media. SNCA also underwent a truncation when taken up by …
The Wholehearted Embrace: My First Hdsa Convention,
2012
University of San Diego
The Wholehearted Embrace: My First Hdsa Convention, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Yale’S Partnership Against Huntington’S Disease: An Alumnus Reconnects And Finds Hope As Scientists Pursue 'Viagra For The Brain' And Other Solutions,
2012
University of San Diego
Yale’S Partnership Against Huntington’S Disease: An Alumnus Reconnects And Finds Hope As Scientists Pursue 'Viagra For The Brain' And Other Solutions, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
A Compassionate Allowance, And Faster Social Security Benefits, For The Juvenile Huntington's Disease Community: A Key Step For Advocacy,
2012
University of San Diego
A Compassionate Allowance, And Faster Social Security Benefits, For The Juvenile Huntington's Disease Community: A Key Step For Advocacy, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Development Of A Microfluidic Device Coupled To Microdialysis Sampling For The Pre-Concentration Of Cytokines,
2012
University of Arkansas, Fayetteville
Development Of A Microfluidic Device Coupled To Microdialysis Sampling For The Pre-Concentration Of Cytokines, Randy Francisco Espinal Cabrera
Graduate Theses and Dissertations
A proof-of-concept microfluidic device combined with heparin-immobilized magnetic beads was created to concentrate cytokine proteins collected from microdialysis samples. Cytokines are known to be related to several diseases such as cancer, and Parkinson's diseases, so to be able to develop more effective diseases treatments their interactions have to be well understood. Amine-functionalized polystyrene and carboxyl-functionalized magnetic microspheres of ~6.0 ìm in diameter were used to immobilize heparin. The amount of heparin immobilized on polystyrene beads was 5.82 x 10-8 ± 0.36 x 10-8 M per 1.0 x 106 beads and for magnetic beads was 0.64 x 10-8 ± 0.01 x …
Improved Techniques For Acquisition And Analysis Of Dynamic Contrast-Enhanced Magnetic Resonance Imaging For Detecting Vascular Permeability In The Central Nervous System,
2012
The University of Texas Graduate School of Biomedical Sciences at Houston
Improved Techniques For Acquisition And Analysis Of Dynamic Contrast-Enhanced Magnetic Resonance Imaging For Detecting Vascular Permeability In The Central Nervous System, Cheukkai Hui
Dissertations and Theses (Open Access)
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a noninvasive technique for quantitative assessment of the integrity of blood-brain barrier and blood-spinal cord barrier (BSCB) in the presence of central nervous system pathologies. However, the results of DCE-MRI show substantial variability. The high variability can be caused by a number of factors including inaccurate T1 estimation, insufficient temporal resolution and poor contrast-to-noise ratio. My thesis work is to develop improved methods to reduce the variability of DCE-MRI results. To obtain fast and accurate T1 map, the Look-Locker acquisition technique was implemented with a novel and truly centric k-space segmentation scheme. In …
Novel Use Of Dual Anti-Inflammatory Therapy To Overcome Drug Resistance And Improve Functional Recovery Following Spinal Cord Injury,
2012
The University of Texas Graduate School of Biomedical Sciences at Houston
Novel Use Of Dual Anti-Inflammatory Therapy To Overcome Drug Resistance And Improve Functional Recovery Following Spinal Cord Injury, Jennifer Dulin
Dissertations and Theses (Open Access)
Over 1.2 million Americans are currently living with a traumatic spinal cord injury (SCI). Despite the need for effective therapies, there are currently no proven effective treatments that can improve recovery of function in SCI patients. Many therapeutic compounds have shown promise in preclinical models of SCI, but all of these have fallen short in clinical trials.
P-glycoprotein (Pgp) is an active transporter expressed on capillary endothelial cell membranes at the blood-spinal cord barrier (BSCB). Pgp limits passive diffusion of blood-borne drugs into the CNS, by actively extruding drugs from the endothelial cell membrane. Pgp can become pathologically up-regulated, thus …
Parkinson’S Disease: Molecular Mechanisms And Treatments,
2012
Liberty University
Parkinson’S Disease: Molecular Mechanisms And Treatments, Delia Vahey
Senior Honors Theses
Parkinson’s disease is a motor system disorder that is caused primarily by the loss of dopamine-producing brain cells. The most affected brain structure is the pars compacta of the substantia nigra. This area of the brain is essential to the control of voluntary movement, and so its impairment leads to symptoms such as tremors, rigidity, and impaired balance. The neuronal protein alpha-synuclein has been shown to be heavily involved in the pathogenesis of the disease at the cellular level. The currently available treatments for PD mainly target dopamine regulation, and there been no cure developed for the disease at present. …
From A Paralyzed Genius, Lessons Of Determination And Caregiving For The Huntington's Community,
2012
University of San Diego
From A Paralyzed Genius, Lessons Of Determination And Caregiving For The Huntington's Community, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Binding Efficacy Of Different Polyphenolic Phytochemicals With Β-Lactoglobulin And Human Serum Albumin: Implication For Therapeutics Against Neurodegenerative Diseases,
2012
Department of Chemistry, University of Texas at El Paso
Binding Efficacy Of Different Polyphenolic Phytochemicals With Β-Lactoglobulin And Human Serum Albumin: Implication For Therapeutics Against Neurodegenerative Diseases, Rene Duran^, Andres Ortiz^, Mahesh Narayan*, Vladik Kreinovich*
COURI Symposium Abstracts, Spring 2012
No abstract provided.
The Team Hope Walk: Reinforcing The First Line Of Defense Against Huntington's Disease,
2012
University of San Diego
The Team Hope Walk: Reinforcing The First Line Of Defense Against Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Biotinidase Deficiency In Pakistani Children; What Needs To Be Known And Done,
2012
Aga Khan University
Biotinidase Deficiency In Pakistani Children; What Needs To Be Known And Done, Bushra Afroze, Mohammad Wasay
Department of Medicine
No abstract provided.
A New, More Holistic View Of Huntington’S Disease: The Systems/P4 Approach,
2012
University of San Diego
A New, More Holistic View Of Huntington’S Disease: The Systems/P4 Approach, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
The First Dose Is Hope: Moving Towards Treatments For Huntington's Disease,
2012
University of San Diego
The First Dose Is Hope: Moving Towards Treatments For Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Top Researcher: ‘Genuine Optimism’ About Treatments For Huntington's Disease,
2012
University of San Diego
Top Researcher: ‘Genuine Optimism’ About Treatments For Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
It’S Time For The Huntington’S Community To Speak Out - And Hdsa Is Listening,
2012
University of San Diego
It’S Time For The Huntington’S Community To Speak Out - And Hdsa Is Listening, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
The Quandary Of Denial In The Huntington’S Disease Community (Part Ii),
2012
University of San Diego
The Quandary Of Denial In The Huntington’S Disease Community (Part Ii), Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
