The Huntington's Disease High-Wire Act,
2011
University of San Diego
The Huntington's Disease High-Wire Act, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
S.O.S. For Huntington's Disease Families, And An Important Bill In Congress,
2011
University of San Diego
S.O.S. For Huntington's Disease Families, And An Important Bill In Congress, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Holding The Potential Cure In My Hand,
2011
University of San Diego
Holding The Potential Cure In My Hand, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
The Huntington’S Community Rising And Converging,
2011
University of San Diego
The Huntington’S Community Rising And Converging, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Bin Laden And Hd,
2011
University of San Diego
Bin Laden And Hd, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
The Diary Of A Huntington's Disease Activist,
2011
University of San Diego
The Diary Of A Huntington's Disease Activist, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
The Shadow Career,
2011
University of San Diego
The Shadow Career, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Let’S Fix The Law To Help Huntington’S Families,
2011
University of San Diego
Let’S Fix The Law To Help Huntington’S Families, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
The Faceless Faces Of Huntington's Disease,
2011
University of San Diego
The Faceless Faces Of Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Can We Stop The Stroke Epidemic In Pakistan?,
2011
Shifa International Hospital
Can We Stop The Stroke Epidemic In Pakistan?, Ismail A. Khatri, Mohammad Wasay
Department of Medicine
No abstract provided.
Characterization Of Amino Acid Residues Integral To Neuronal Binding Of Amyloid Beta Protein In Alzheimer’S Disease,
2011
California Polytechnic State University, San Luis Obispo
Characterization Of Amino Acid Residues Integral To Neuronal Binding Of Amyloid Beta Protein In Alzheimer’S Disease, Nicole C. Olson
Chemistry and Biochemistry
Purpose: Alzheimer’s Disease is a neurodegenerative disease resulting from over-production and neuronal accumulation of amyloid-beta proteins (Aβ40/Aβ42). The glycine residue at position 33 and histidine residues at positions 13 and 14 are involved with binding and internalization of these proteins, actions potentially inhibited by substituting or sterically hindering these residues with an antibody specific to positions 2-11 (IgG-4.1). Rat pheochromocytoma (PC12) cells differentiated with nerve growth factor were used as a neuronal model to determine whether substitution and/or antibody block amyloid-beta’s neuronal interactions.
Methods: PC12 cells were incubated with fluorescein-labeled-amyloid-beta-40 (F-Aβ40) or substituted F-Aβ40 derivatives (F-Aβ40-H13,14G, F-Aβ40-H13,14G;G33A), with or without …
Huntington’S Disease, Loneliness, And Love,
2011
University of San Diego
Huntington’S Disease, Loneliness, And Love, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
A Cascade Of Emotions About Huntington’S Disease,
2011
University of San Diego
A Cascade Of Emotions About Huntington’S Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Huntington’S Support Group: Seeking Solidarity, Fighting Denial,
2011
University of San Diego
Huntington’S Support Group: Seeking Solidarity, Fighting Denial, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Coming Down From Coming Out: Recharging The Activism Batteries,
2011
University of San Diego
Coming Down From Coming Out: Recharging The Activism Batteries, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
‘Drug Hunters’ Bring Hope To Huntington’S Families,
2011
University of San Diego
‘Drug Hunters’ Bring Hope To Huntington’S Families, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Unmasking Gene Veritas: A Huntington's Disease Activist Goes Public,
2011
University of San Diego
Unmasking Gene Veritas: A Huntington's Disease Activist Goes Public, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
A Survey Of Oxidative Paracatalytic Reactions Catalyzed By Enzymes That Generate Carbanionic Intermediates: Implications For Ros Production, Cancer Etiology, And Neurodegenerative Diseases,
2011
New York Medical College
A Survey Of Oxidative Paracatalytic Reactions Catalyzed By Enzymes That Generate Carbanionic Intermediates: Implications For Ros Production, Cancer Etiology, And Neurodegenerative Diseases, Victoria Bunik, John Schloss, John T. Pinto, Natalia Dudareva, Arthur J L Cooper
NYMC Faculty Publications
Enzymes that generate carbanionic intermediates often catalyze paracatalytic reactions with O2 and other electrophiles not considered “normal” reactants. For example, pyridoxal 5′-phosphate (PLP)—containing pig kidney dopa decarboxylase oxidizes dopamine with molecular O2 to 3,4-dihydroxyphenylacetaldehyde at about 1% of the rate at which it catalyzes nonoxidative dopa decarboxylation. The mutant Y332F enzyme, however, catalyzes stoichiometric conversion of dopa to 3,4-dihydroxyphenylacetaldehyde, suggesting that even minor structural changes may alter or initiate paracatalytic reactions catalyzed by certain enzymes. Carbanions generated by several thiamine diphosphate (ThDP)—dependent enzymes react with different electrophiles, transforming some xenobiotics and endogenous compounds into potentially biologically hazardous products. The detrimental …
Feeling Like An Alien: Going Public About Huntington's,
2011
University of San Diego
Feeling Like An Alien: Going Public About Huntington's, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Unifying The Mathematical Modeling Of In Vivo And In Vitro Microdialysis,
2011
National Institutes of Health
Unifying The Mathematical Modeling Of In Vivo And In Vitro Microdialysis, Peter M. Bungay, Rachita K. Sumbria, Ulrich Bickel
Pharmacy Faculty Articles and Research
A unifying approach is presented for developing mathematical models of microdialysis that are applicable to both in vitro and in vivo situations. Previous models for cylindrical probes have been limited by accommodating analyte diffusion through the surrounding medium in the radial direction only, i.e., perpendicular to the probe axis, or by incomplete incorporation of diffusion in the axial direction. Both radial and axial diffusion are included in the present work by employing two-dimensional finite element analysis. As in previous models, the nondimensional clearance modulus (Θ) represents the degree to which analyte clearance from the external medium influences diffusion through the …
