Clinical, Diagnostic, And Metabolic Characteristics Associated With Nephrolithiasis In The Black Women's Health Study, 2024 Thomas Jefferson University
Clinical, Diagnostic, And Metabolic Characteristics Associated With Nephrolithiasis In The Black Women's Health Study, Maria D'Amico, Richard K. Babayan, David S. Wang, Shaun Wason, Yvette C. Cozier
Jefferson Hospital Staff Papers and Presentations
Background/Objectives: Nephrolithiasis (kidney stones) is a frequently occurring urologic condition resulting in significant patient morbidity and healthcare costs. Despite the higher prevalence of metabolic risk factors for nephrolithiasis among Black women, there have been few epidemiologic studies of kidney stones focusing on this group.
Methods: We describe demographic and health characteristics, diagnostics, and metabolic profiles of US Black women with self-reported kidney stones. The women were participants in the Black Women’s Health Study (BWHS), a large prospective cohort of US Black women (median age 38 years) begun in 1995.
Results: Among the 2750 BWHS participants who completed an online supplemental …
Trace Out The Improvement Level And Awareness Of Polycyctic Ovary Syndrome (Pcos) Among General People And Educational Institute Of Developed And Developing Countries, 2024 Institute of Pure and Applied Zoology University of Okara, Punjab, Pakistan
Trace Out The Improvement Level And Awareness Of Polycyctic Ovary Syndrome (Pcos) Among General People And Educational Institute Of Developed And Developing Countries, Muhammad Rizwan, Maryam Mushtaq, Asif Bilal, Tabassum Nawaz, Kashif Riaz, Maria Hussain, Mirza Fahad Baig, Saira Ashfaq, Ayesha Mushtaq, Umair Riaz, Mariya Basharat
Journal of Bioresource Management
One of the most prevalent hormonal problems which affect women is polycystic ovary syndrome (PCOS). It consists of several fundamentals, including reproductive, metabolic, and cardiovascular ones, and has effects on the patient's health throughout the duration of their life. Limited data is available on PCOS in developing countries like Pakistan. The aim of our study is to trace out the prevalence of PCOS in developed countries like America and China as well as developing countries like Pakistan. The study was done in the above mention developed and developing countries through the interviews of people by online questionnaire. This survey research …
Surviving The Shock: Critical Management Of Klebsiella Pneumoniae Septic Shock In A Pregnant Patient, 2024 The University of Texas Rio Grande Valley School of Medicine
Surviving The Shock: Critical Management Of Klebsiella Pneumoniae Septic Shock In A Pregnant Patient, Oliverio J. Abarca Guzman, Michelle Minero
Research Colloquium
Background: Klebsiella pneumoniae bacteremia is a known cause of septic shock, but its occurrence in the context of chorioamnionitis during pregnancy, especially with imminent abortion of one twin, is rare. This case report highlights the critical care management and outcomes of a 24-year-old woman who developed septic shock due to Klebsiella pneumoniae bacteremia.
Case Presentation: A 24-year-old gravida 4, para 2 woman at 17 weeks gestation with a dichorionic diamniotic twin pregnancy presented in septic shock after delivering a nonviable twin A at home. Suspected sepsis secondary to chorioamnionitis with retained placenta was confirmed by laboratory results showing Klebsiella pneumoniae …
Exploring Perinatal Ketamine For Postpartum Depression Following Cesarean Section: A Systematic Review, 2024 Rowan University
Exploring Perinatal Ketamine For Postpartum Depression Following Cesarean Section: A Systematic Review, Jaylyn Thompson, David F Lo, Alexis Foschini, Suvan Sundaresh
Rowan-Virtua School of Osteopathic Medicine Departmental Research
The aim of this study was to explore the use of perinatal ketamine to see if it can be used for the reduction of postpartum depression (PPD) following cesarean section (C-section). PubMed, Cochrane, and Web of Science were the primary databases used for this review. Search terms used on January 5, 2024 incorporated "ketamine," "C-section," "postpartum depression," and related synonyms. The criteria for inclusion centered on studies published between January 1, 2008 and January 5, 2024. The final selection of articles was screened based on extraction criteria leaving eight randomized control trials in the final review. The selected data from …
The Transfer Of Molnupiravir And Nirmatrelvir Across The Human Placenta And Prediction Of Drug Safety In Pregnancy, 2024 Western University
The Transfer Of Molnupiravir And Nirmatrelvir Across The Human Placenta And Prediction Of Drug Safety In Pregnancy, Magdalene Zabek
Electronic Thesis and Dissertation Repository
Molnupiravir and nirmatrelvir are effective COVID-19 therapeutics, however there is limited data on their safety during pregnancy. The objective is to quantify the placental transfer of nirmatrelvir and b-D-N4-hydroxycytidine (NHC), the metabolite of molnupiravir found in plasma. A systematic review on the pharmacokinetics of nirmatrelvir found no data in pregnant subjects, though several studies reported parameters in non-pregnant individuals such as CL, VD, and fu. Using the ex vivo human placental perfusion model, nirmatrelvir showed a fetal-maternal concentration ratio (F:M) of 0.34 at therapeutic doses (2.21 µg/mL) and 0.46 (22.1 µg/mL) at supratherapeutic doses. Adjusted F:M …
Syphilitic Gumma Presenting As Squamous Cell Carcinoma Of Vulva: A Case Report, 2024 University of Oklahoma at Tulsa
Syphilitic Gumma Presenting As Squamous Cell Carcinoma Of Vulva: A Case Report, R.M. Nuss, A.J. Lazenby, Holly C. Provost, Tara Castellano
School of Medicine Faculty Publications
Introduction: Tertiary syphilis, a late form of the disease with neurologic, cutaneous, and cardiovascular manifestations, is rarely seen in the United States in modern times. Also called the “great imitator,” syphilis tends to mimic other disease processes, which can lead to a delay in proper diagnosis and treatment. Case: We present the case of a 59-year-old woman who presented for evaluation of possible squamous cell carcinoma of the vulva. After multiple inconclusive biopsies and extensive workup with multiple providers, she was instead found to have cutaneous and neurologic tertiary syphilis. A correct diagnosis was delayed in this patient due to …
Device-Based Measures Of Maternal Physical Activity, Pregnancy Nocturnal Glucose, Postpartum Sleep, And Infant Adiposity, 2024 University of Tennessee, Knoxville
Device-Based Measures Of Maternal Physical Activity, Pregnancy Nocturnal Glucose, Postpartum Sleep, And Infant Adiposity, Bethany R. Hallenbeck
Doctoral Dissertations
This dissertation presents physical activity, sedentary behavior, and bedrest (sleep estimation) data from ActiGraph devices worn during pregnancy and postpartum. Analyses of these data consider how these behaviors may relate to each other and health outcomes in the mother and child. The research aims to bridge the gap in understanding the intricate relationship between physical activity health behaviors and maternal and infant health metrics during the critical phases of pregnancy and postpartum. For this work, we employed repeated measures mixed modelling and integrated device-based, research-grade, ActiGraph data with clinical measures and survey responses to elucidate the multifaceted dynamics influencing a …
Cord Blood Troponin I Levels: Biomarker Evidence Of Fetal Cardiac Injury In Intrahepatic Cholestasis Of Pregnancy, 2024 Thomas Jefferson University
Cord Blood Troponin I Levels: Biomarker Evidence Of Fetal Cardiac Injury In Intrahepatic Cholestasis Of Pregnancy, Itamar Futterman, Hitangee Jain, Rodney Mclaren, Jonathan Mays
Department of Obstetrics and Gynecology Faculty Papers
BACKGROUND: Intrahepatic cholestasis of pregnancy has been linked to sudden stillbirth. The suddenness of the stillbirths in these cases have led clinicians to suspect that the pathogenesis of stillbirth in women with intrahepatic cholestasis of pregnancy is not related to asphyxia but rather to an undefined etiology. One leading hypothesis relates certain bile acid metabolites to myocardial injury. OBJECTIVE: The purpose of this study was to determine whether cord blood troponin I levels are increased in fetuses born to mothers with a diagnosis of intrahepatic cholestasis of pregnancy. STUDY DESIGN: A prospective, case-control study was performed at a single institution …
Bd Vaginal Panel Assay Results On The High-Throughput Bd Cor System Compared To The Bd Max System, 2024 Becton, Dickinson and Company, BD Life Sciences-Diagnostic Solutions, Sparks, MD
Bd Vaginal Panel Assay Results On The High-Throughput Bd Cor System Compared To The Bd Max System, Elizabeth Stonebraker, Wallace Greene, Stephanie N. Taylor, Catherine L. Cammarata, April Bobenchik, Elizabeth Lockamy
School of Medicine Faculty Publications
Molecular-based assays demonstrate excellent sensitivity for the detection of vaginitis causes. Here, the high-throughput BD Vaginal Panel for BD COR System (VP-COR) performance was compared to that of the predicate, BD MAX Vaginal Panel for BD MAX System (VP-MAX). Clinical or contrived samples were used to determine the agreement between VP-COR and VP-MAX. Acceptance criteria for VP-COR agreement were as follows: bacterial vaginosis (BV) required a positive percent agreement (PPA) point estimate of ≥ 95% and a negative percent agreement (NPA) point estimate of ≥ 98%; Candida group, Candida glabrata, Candida krusei, and Trichomonas vaginalis (TV) required a PPA and …
The Use And Effectiveness Of Diet And Physical Activity As Interventions For Polycystic Ovary Syndrome. A Review., 2024 Georgia College & State University
The Use And Effectiveness Of Diet And Physical Activity As Interventions For Polycystic Ovary Syndrome. A Review., Caroline C. Jones, Jinkyung Park
The Corinthian
Polycystic Ovary Syndrome (PCOS) is a hormonal disorder that is common among women who are of reproductive age, most commonly in ages between 15 and 44 years of age (Moran et al., 2010). While the exact cause of PCOS is unknown, it is widely believed by many experts that genetic factors including excess levels of insulin and excess androgen are attributing factors (Moran et al., 2010) . Women with PCOS experience several different signs and symptoms including; infrequent or prolonged menstrual periods leading to infertility and the development of cysts (Iatrakis et al., 2006). Some other common symptoms of PCOS …
A Rare Intervention: Perimortem Hysterotomy In An Obstetric Emergency In A 32-Year-Old Female, 2024 Jefferson Health NJ
A Rare Intervention: Perimortem Hysterotomy In An Obstetric Emergency In A 32-Year-Old Female, Alex Mirchandani
Rowan-Virtua Research Day
In the realm of obstetric emergencies, perimortem hysterotomy stands as a rare but crucial intervention, employed in dire circumstances to salvage both maternal and fetal lives. This procedure, involving the surgical delivery of a fetus from a mother in cardiac arrest, presents a unique set of challenges and ethical considerations for healthcare providers. This case report delves into the intricate details surrounding a perimortem hysterotomy performed under emergent conditions, exploring the clinical decision-making process, procedural intricacies, and outcomes. Through this narrative, we aim to shed light on the complexities of managing obstetric emergencies, emphasizing the critical role of timely intervention …
Case Report: An Emergency Department Presentation Of An Ovarian Teratoma, 2024 Jefferson Health NJ
Case Report: An Emergency Department Presentation Of An Ovarian Teratoma, David Marconi, Zamron Masih
Rowan-Virtua Research Day
A teratoma (from the Greek terato for “monster” and onkoma for “mass” or “swelling”) is a type of neoplasm composed of tissues from two or three germ layers. Mature cystic teratomas (MCTs) constitute 70% of all ovarian neoplasms. They typically present with nonspecific symptoms such as pain and nausea. They account for approximately 2% of all primary ovarian malignant cancers and are predominately diagnosed via ultrasound. Computed tomography may be necessary if malignancy is suspected. Larger size warrants a higher suspicion of malignancy. Management is symptom control and ultimately, surgical removal. Prognosis is generally excellent, provided there is no malignant …
Use Of Point-Of-Care Ultrasound In The Diagnosis Of Postpartum Cardiomyopathy, 2024 Jefferson Health NJ
Use Of Point-Of-Care Ultrasound In The Diagnosis Of Postpartum Cardiomyopathy, Muhammad Noman, Frank A. Wheeler, James A. Espinosa, Alan Lucerna
Rowan-Virtua Research Day
Postpartum cardiomyopathy (PPCM), also known as peripartum cardiomyopathy is a rare form of heart failure (HF) that occurs in the late stages of pregnancy or in the early postpartum period. For it to be classified as PPCM, it must occur in the absence of another identifiable cause for HF and have left ventricular (LV) systolic dysfunction with an LV ejection fraction (LVEF) less than 45%. Here we present the case of a 46-year-old female G3P2 presented 5 days postpartum cesarean section delivery in acute respiratory distress where point of care ultrasound was used for assessment of the lungs to visualize …
Dermoid Cyst – Presenting With Llq Abdominal Pain, 2024 Jefferson Health NJ
Dermoid Cyst – Presenting With Llq Abdominal Pain, Mohammad A. Rattu, James A. Espinosa
Rowan-Virtua Research Day
Ovarian cysts are fluid-filled structures that may be defined as simple or complex and are often discovered incidentally on imaging. Their etiology can range from physiologically normal (such as follicular or luteal cysts) to ovarian malignancies. They are more common in the reproductive years secondary to endogenous hormonal production however may also occur at any age. Simple cysts more commonly occur among all age groups; mixed cystic and solid and completely solid ovarian lesions however have rates of increased malignancy. The most independent risk factor is age; therefore, post-menopausal women should have proper follow-up secondary to this risk. Some risk …
Maternal Health Outcomes Of The Least And Most Vulnerable Counties In Nj, 2024 Rowan University
Maternal Health Outcomes Of The Least And Most Vulnerable Counties In Nj, Nayarith Lopez
Rowan-Virtua Research Day
- Maternal health continues to be of great concern in the United States.
-The maternal mortality rate for 2021 was 32.9 deaths per 100,000 live births, an increase from both 2020 and 2021.1
-The leading causes of pregnancy-related death are mental health, hemorrhage, and cardiovascular conditions. Most are preventable.2
-New Jersey ranks 27th, with 24.1 deaths occurring within 42 days of the end of a pregnancy per 100,000 live births.3
-While rates for the entire state show a need for improvement, in comparison to northern and central regions, rates in the southern region of NJ are approximately twice the state …
What Is The Efficacy Of The Newly Developed Hpv Vaccine, Cecolin, In Providing Protection Against Hpv-Induced Cervical Cancers In Females Aged 9-14 Years Old, 2024 Rowan University
What Is The Efficacy Of The Newly Developed Hpv Vaccine, Cecolin, In Providing Protection Against Hpv-Induced Cervical Cancers In Females Aged 9-14 Years Old, Yolanda Williams
Rowan-Virtua Research Day
In low to middle income countries, there's a rise in invasive cervical squamous cell carcinoma. Affordability emerges as a crucial factor influencing this trend. This research is based on the development of a new HPV vaccine made in China called Ceolin priced at $47 and its efficacy to be incorporated into the WHO vaccination program. A peer review was conducted based on an ongoing randomized phase 3 clinical trial of a 2 dose regimen bivalent Cecolin vaccine (types 16,18) . The study includes 1025 females aged 9-14 years old split amongst 5 groups. The control group received Gardasil at the …
Management Strategies For Traumatic Injuries In Pregnant Women: A Comprehensive Literature Review, 2024 Rowan University
Management Strategies For Traumatic Injuries In Pregnant Women: A Comprehensive Literature Review, Jaylyn D. Thompson, Jenna Zappetti, Clarence Julian Clark Ii
Rowan-Virtua Research Day
Introduction: Traumatic injuries in pregnant women are the leading cause of non-obstetric death and affect 6% to 8% of all pregnancies. Therefore, it is imperative to maintain updated guidelines to construct a framework for the optimal management strategies for traumatic injuries in pregnant women, considering the perspectives of obstetrics/gynecology, emergency medicine, and orthopedics.
Methods: To conduct this study, research was done via a database search through the Rowan-Virtua School of Osteopathic Medicine’s research library. PubMed was the sole database used to review 8 peer-reviewed sources. Articles that were published within the last 10 years were chosen.
Results: Every woman with …
Addressing The Black Maternal Mortality Rate, 2024 Rowan University
Addressing The Black Maternal Mortality Rate, Kennedy Sanders, Venkateswar Venkataraman, Kate Whelihan
Rowan-Virtua Research Day
Introduction: As of 2021, the Black maternal mortality rate in the United States was 69.9 deaths per 100,000 live births as compared to the national average of 32.9 and the White American average of 26.61. It has been demonstrated that this discrepancy is not fully explained by socioeconomic status. Doulas are professionals who provide support and guidance throughout pregnancy, birth, and early parenthood. Encouraging the use of doulas may be an effective approach to improve the birth experience for Black mothers. Methods: A literature review was performed using PubMed and the following search strings: maternal mortality rate (+race, +race +ethnicity, …
Investigating The Efficacy Of Myo-Inositol In Adolescents With Polycystic Ovary Syndrome: A Scoping Review, 2024 Rowan University
Investigating The Efficacy Of Myo-Inositol In Adolescents With Polycystic Ovary Syndrome: A Scoping Review, Mariam Sharobeem
Rowan-Virtua Research Day
Polycystic ovary syndrome (PCOS) affects approximately 6 to 13% of adolescent girls in the United States.6 PCOS poses difficulty with diagnosing and treatment with adolescents as its symptoms are heterogenous and are often rationalized with other diagnoses. Key diagnostic features of PCOS include irregular menstruation, infertility, obesity, hirsutism, increased risk of diabetes mellitus, hypertension, lipid abnormalities and metabolic syndrome.12 Currently, there are no pharmacological therapies approved by the FDA to treat PCOS.5 Alternatives include pharmacological management of symptoms with medications like combined oral contraceptive pills, metformin and anti-obesity agents.6 Recently, more discussion about the lack of PCOS treatment has been …
Barriers In Health Care Leading To High Maternal Mortality Rates In Southern New Jersey, 2024 Rowan University
Barriers In Health Care Leading To High Maternal Mortality Rates In Southern New Jersey, Katarina Rusinak, Muznah Khan, Ava Dinardo, Nayarith Lopez
Rowan-Virtua Research Day
Maternal mortality remains a significant issue in New Jersey, particularly in the Southern counties where rates are alarmingly high. This study investigates barriers faced by mothers in these areas, utilizing data from state health departments, as well as the CDC. Findings reveal clear disparities in healthcare access and resources, exacerbated by high poverty and rural settings. Proposed interventions include educational posters and community workshops to empower expecting mothers and families. However, challenges such as low attendance and limited effectiveness of interventions underscore the need for comprehensive, sustainable solutions to tackle maternal mortality in Southern New Jersey.