Donepezil And Galanin Interactions In An Animal Model Of Alzheimer’S Disease,
2010
University of Nevada, Las Vegas
Donepezil And Galanin Interactions In An Animal Model Of Alzheimer’S Disease, Jonathan J. Sabbagh
UNLV Theses, Dissertations, Professional Papers, and Capstones
Alzheimer's disease (AD) is a neurodegenerative disorder marked by a progressive loss of cognitive function. One of the neurobiological hallmarks of AD is a progressive loss of cholinergic neurons and a decrease in the amount of acetylcholine in the brain. Pharmacological therapies have targeted the cholinergic system, specifically first-line, palliative treatment using acetylcholinesterase (AChE) inhibitors, such as donepezil. Donepezil has been shown to increase cholinergic tone and ameliorate some of the cognitive deficits in AD patients. Galanin, a neuropeptide that inhibits the evoked release of several neurotransmitters including acetylcholine as well as modulates seveal intracellular cascades, is overexpressed in AD …
Enjoying The Life We Have Left,
2010
University of San Diego
Enjoying The Life We Have Left, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
An Expedition To The Brain,
2010
University of San Diego
An Expedition To The Brain, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Losing Control, Seeking Connections,
2010
University of San Diego
Losing Control, Seeking Connections, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Out Of The Closet And On To The Cure,
2010
University of San Diego
Out Of The Closet And On To The Cure, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
More To Lose Than Ever',
2010
University of San Diego
More To Lose Than Ever', Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Living In Limbo,
2010
University of San Diego
Living In Limbo, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
My Friend, The Fast Lane,
2010
University of San Diego
My Friend, The Fast Lane, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Traveling Across America, Togetherness And Memories,
2010
University of San Diego
Traveling Across America, Togetherness And Memories, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Hyperprolactinaemia Induced By Proton Pump Inhibitor,
2010
Aga Khan University
Hyperprolactinaemia Induced By Proton Pump Inhibitor, Abdul Jabbar, Rabbia Khan, Syed Nadir Farrukh
Section of Internal Medicine
A case of a 13 year old girl who manifested hyperprolactinaemia and galactorrhea induced by Omeprazole, a commonly used proton pump inhibitor is presented.
Charting New Territory: Going Public About Hd,
2010
University of San Diego
Charting New Territory: Going Public About Hd, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
God, Huntington's Disease And The Meaning Of Life,
2010
University of San Diego
God, Huntington's Disease And The Meaning Of Life, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Dad, Could You Get Hd?',
2010
University of San Diego
Dad, Could You Get Hd?', Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
A Perfect Day: The Sunset Of A Meaningful Life,
2010
University of San Diego
A Perfect Day: The Sunset Of A Meaningful Life, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Care Versus Cure: We Can Progress In Both,
2010
University of San Diego
Care Versus Cure: We Can Progress In Both, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Eye Movement Measures Of Cognitive Control In Children With To Urette Syndrome,
2010
University of Texas Graduate School of Biomedical Sciences at Houston
Eye Movement Measures Of Cognitive Control In Children With To Urette Syndrome, Cameron B. Jeter
Dissertations and Theses (Open Access)
Tourette Syndrome begins in childhood and is characterized by uncontrollable repetitive actions like neck craning or hopping and noises such as sniffing or chirping. Worst in early adolescence, these tics wax and wane in severity and occur in bouts unpredictably, often drawing unwanted attention from bystanders. Making matters worse, over half of children with Tourette Syndrome also suffer from comorbid, or concurrent, disorders such as attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD). These disorders introduce anxious thoughts, impulsivity, inattention, and mood variability that further disrupt children with Tourette Syndrome from focusing and performing well at school and home. …
Tetrahydroisoquinoline Neurotoxins In Parkinson Disease,
2010
University of Tennessee Health Science Center
Tetrahydroisoquinoline Neurotoxins In Parkinson Disease, Michael G. Decuypere
Theses and Dissertations (ETD)
The goal of this dissertation work was to (1) determine the distribution of several tetrahydroisoquinoline (TIQ) derivatives in rodent, normal human and Parkinson disease (PD) brain, (2) quantify the levels of these TIQ derivatives in common food sources in an effort to link specific food intake patterns with the development of PD and (3) examine the neurotoxicity of select TIQ derivatives in human dopaminergic cell culture. The TIQs are a family of monoamine alkaloids that share structural homology with 1-methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (MPTP), can be formed from dopamine or its oxidized metabolites and may be involved in the pathogenesis of monoaminergic cell …
Pain Management In Nursing Home Residents With Cancer And Dementia With And Without Hospice Services,
2010
University of Tennessee Health Science Center
Pain Management In Nursing Home Residents With Cancer And Dementia With And Without Hospice Services, Todd Bryant Monroe
Theses and Dissertations (ETD)
Aims: We sought to identify differences in pain management between two groups; nursing home residents with malignant cancer and dementia with and without hospice services.
Methods: Decedent records from 2003-2009 were assessed for diagnosis of dementia and cause of death as cancer. Ten malignant cancer diagnoses were determined a priori from the CDC 2004 data on the top 10 malignant cancers for all races and genders. Fifty-five decedents from 10 nursing homes were included in the final sample. Four instruments were used: Minimum Data Set (MDS) a standardized assessment tool required of most U.S. nursing homes. A large …
Ten Reasons To Cure Hd,
2010
University of San Diego
Ten Reasons To Cure Hd, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
The Point Of No Return,
2010
University of San Diego
The Point Of No Return, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
