Memories Of The Dna Car,
2011
University of San Diego
Memories Of The Dna Car, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Infection Of Neuronal Cells By Chlamydia Pneumoniae And Herpes Simplex Virus Type 1 Alters Expression Of Genes Associated With Alzheimer’S Disease,
2011
Phila College of Osteopathic Medicine
Infection Of Neuronal Cells By Chlamydia Pneumoniae And Herpes Simplex Virus Type 1 Alters Expression Of Genes Associated With Alzheimer’S Disease, Morgan M. Devins, Fiora D. Zoga, Brian J. Balin, Denah M. Appelt, Susan T. Hingley
Scholarly Posters
Several studies have suggested an infectious etiology for Alzheimer’s disease (AD). We have been investigating a potential role for both Chlamydia pneumoniae and Herpes simplex virus type 1 (HSV1) in the initiation of sporadic late-onset AD. Our current study focuses on investigation of gene expression using Alzheimer-specific Real-Time PCR microarrays on RNA derived from SKNMC human neuronal cells infected with C. pneumoniae and/or HSV1. There are distinct differences in the patterns of gene regulation by the two pathogens. For example, C. pneumoniae induces expression of genes involved in amyloid production and processing, such as β-amyloid precursor protein (APP), β-site APP-cleaving …
Analysis Of Chlamydia Pneumoniae And Ad-Like Pathology In The Brains Of Balb/C Mice Following Direct Intra-Cranial Infection,
2011
Philadelphia College of Osteopathic Medicine
Analysis Of Chlamydia Pneumoniae And Ad-Like Pathology In The Brains Of Balb/C Mice Following Direct Intra-Cranial Infection, Jessica Rachel Barton, Christine J. Hammond, Amy L. Brady, Denah M. Appelt, Brian J. Balin, Christopher Scott Little
Scholarly Posters
Alzheimer’s disease (AD) is an age-related progressive neurodegenerative disorder and the most common form of dementia. The pathology in the central nervous system (CNS) impairs memory and cognition, hindering the capabilities and the quality of life of the individual. This project continues studying the role of infection and Alzheimer’s disease, as previous studies in this laboratory have done, and contributes to the overall understanding of the possible causes of this disease. In this study, BALB/c mice were infected, via direct intracranial injection, with a respiratory isolate (AR-39) of Chlamydia pneumoniae. Their brains were analyzed at 7 and 14 days post-infection, …
Analysis Of Chlamydia Pneumoniae-Infected Monocytes Following Incubation With A Novel Peptide, Acaly18, Implicates The Inflammasome In Clearance Of Infection,
2011
Philadelphia College of Osteopathic Medicine
Analysis Of Chlamydia Pneumoniae-Infected Monocytes Following Incubation With A Novel Peptide, Acaly18, Implicates The Inflammasome In Clearance Of Infection, Brian J. Balin, James D. Thacker, Charles Lim, Corey M. Caruthers, Susan T. Hingley, Juliana Zoga, Denah M. Appelt
Scholarly Posters
Chlamydia pneumoniae infection may be a trigger for the pathology observed in sporadic lateonset Alzheimer’s disease as a function of initiating neuroinflammation following entry of the organism into the brain. We have hypothesized that one entry mechanism may be by bloodborne infected monocytes trafficking the infection into the brain. This study focuses on infection of monocytes in vitro followed by analysis using immunofluorescence labeling and RT-PCR-microarray techniques. The microarrays utilized consisted of an Alzheimer’s disease pathway array and an innate and adaptive immunity array from SAbiosciences. Analysis by real time PCR for both gene arrays was performed on uninfected and …
Gestational Diabetes Clinic For Indigent Latinos,
2011
Philadelphia College of Osteopathic Medicine
Gestational Diabetes Clinic For Indigent Latinos, Sara Wilson Reece
Scholarly Posters
Gestational diabetes mellitus (GDM), “carbohydrate intolerance of variable severity with onset or fist recognition during pregnancy,” results from insulin resistance and relative insulin deficiency usually in second trimester.¹ • Gestational diabetes (GDM) impacts between 4% and 9% of all pregnancies. • Gestational diabetes (GDM) results in increased fetal complications of macrosomia, shoulder dystocia and neonatal hyperglycemia as well as maternal risks of preeclampsia and polyhydramnois. • Women who are Hispanic or Asian decent are at highest risk of developing GDM. • Diagnosis ² • Perform 75-gramoral glucose tolerance test (OGTT) at 24 – 28 weeks of gestation in women not …
Role Of The Vagal System In The Regulatory Sensory Processing Patterns In Children With Autistic Spectrum Disorder: Physiologic Underpinnings And Reliability Of Measurement,
2011
Seton Hall University
Role Of The Vagal System In The Regulatory Sensory Processing Patterns In Children With Autistic Spectrum Disorder: Physiologic Underpinnings And Reliability Of Measurement, Catherine M. Cavaliere
Seton Hall University Dissertations and Theses (ETDs)
This study was a preliminary investigation into the reliability of cardiac vagal tone (CVT) as a measure of regulatory sensory processing in typically developing children and children with autistic spectrum disorders (ASD). We also examined group differences in CVT at rest and in response to sensation and the relationship of CVT to behavioral measures of sensory processing. The goals of this study were to answer three related research questions: 1. Is CVT a reliable measure of regulatory sensory processing? 2. Do children with ASD respond to sensory information differently than typically developing children? 3. Is there a relationship between physiologic …
Alzheimer's Disease Association With Chlamydia Pneumoniae,
2011
Philadelphia College of Osteopathic Medicine
Alzheimer's Disease Association With Chlamydia Pneumoniae, Andrew Short
PCOM Biomedical Studies Student Scholarship
Exogenous bacteria, such as Chlamydia pneumoniae, may be a cause of inflammation that contributes to the progression of Alzheimer's disease (AD). Inflammation has been previously established as a contributor to AD progression. Balin et al. first reported C. pneumoniae in the brains of post-mortem late onset AD patients. PCR analysis showed that 17/19 AD patients were positive for the organism in areas of the brain with typical AD-related neuropathology while 18/19 control patients were PCR-negative. Gerard et al. determined, using real-time PCR, that C. pneumoniae-infected cells colocalize with both neuritic senile plaques and neurofibrillary tangles, the defining pathologies of AD. …
Is L-Carnitine An Effective Treatment To Improve The Quality Of Life For Patients With Rett Syndrome?,
2011
Philadelphia College of Osteopathic Medicine
Is L-Carnitine An Effective Treatment To Improve The Quality Of Life For Patients With Rett Syndrome?, Bernadette Mason
PCOM Physician Assistant Studies Student Scholarship
Objective: To determine “Is L-carnitine an effective treatment to improve the quality of life for patients with Rett Syndrome?”
Identification Of A Second Mimicry Epitope From Acanthamoeba Castellanii That Induces Cns Autoimmunity By Generating Cross-Reactive T Cells For Mbp 89–101 In Sjl Mice,
2011
University of Nebraska-Lincoln
Identification Of A Second Mimicry Epitope From Acanthamoeba Castellanii That Induces Cns Autoimmunity By Generating Cross-Reactive T Cells For Mbp 89–101 In Sjl Mice, Chandirasegaran Massilamany, Oluwatoyin A. Asojo, Arunakumar Gangaplara, David J. Steffen, Jay Reddy
Jay Reddy Publications
We had previously reported that Acanthamoeba castellanii (ACA) contains a mimicry epitope for proteolipid protein 139–151 capable of inducing central nervous system (CNS) autoimmunity in SJL/J mice. We now present evidence that ACA also contains a mimicry epitope for myelin basic protein (MBP) 89–101, a derivative from amoebic nicotinamide adenine dinucleotide dehydrogenase subunit 2 (NAD). The epitope, NAD 108–120, contains a discontinuous stretch of six amino acids in the core region (VVFFKNIILIGFL) sharing 46% identity with MBP 89–101 (VHFFKNIVTPRTP; identical residues are underlined). SJL mice immunized with NAD 108–120 develop encephalomyelitis similar to the disease induced by the cognate peptide. …
Identification Of A Second Mimicry Epitope From Acanthamoeba Castellanii That Induces Cns Autoimmunity By Generating Cross-Reactive T Cells For Mbp 89–101 In Sjl Mice,
2011
University of Nebraska-Lincoln
Identification Of A Second Mimicry Epitope From Acanthamoeba Castellanii That Induces Cns Autoimmunity By Generating Cross-Reactive T Cells For Mbp 89–101 In Sjl Mice, Chandirasegaran Massilamany, Oluwatoyin A. Asojo, Arunakumar Gangaplara, David J. Steffen, Jay Reddy
Jay Reddy Publications
We had previously reported that Acanthamoeba castellanii (ACA) contains a mimicry epitope for proteolipid protein 139–151 capable of inducing central nervous system (CNS) autoimmunity in SJL/J mice. We now present evidence that ACA also contains a mimicry epitope for myelin basic protein (MBP) 89–101, a derivative from amoebic nicotinamide adenine dinucleotide dehydrogenase subunit 2 (NAD). The epitope, NAD 108–120, contains a discontinuous stretch of six amino acids in the core region (VVFFKNIILIGFL) sharing 46% identity with MBP 89–101 (VHFFKNIVTPRTP; identical residues are underlined). SJL mice immunized with NAD 108–120 develop encephalomyelitis similar to the disease induced by the cognate peptide. …
What Modifiable Risk Factors Lead To Strokes In Our Part Of The World,
2011
Aga Khan University
What Modifiable Risk Factors Lead To Strokes In Our Part Of The World, Maria Khan, Ayeesha Kamran Kamal
Section of Neurology
No abstract provided.
The Best Christmas Gift Of All,
2010
University of San Diego
The Best Christmas Gift Of All, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
The Mission Of A Lifetime,
2010
University of San Diego
The Mission Of A Lifetime, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
A Simple Method To Reduce Infection Of Ventriculoperitoneal Shunts Clinical Article,
2010
Aga Khan University
A Simple Method To Reduce Infection Of Ventriculoperitoneal Shunts Clinical Article, Atiq-Ur Rehman, Tausif-Ur Rehman, Hassaan H. Bashir, Vikas Gupta
Department of Medicine
Object: Postoperative shunt infection is the most common and feared complication of ventriculoperitoneal (VP) shunt placement for treatment of hydrocephalus. The rate of shunt infection is highest in the 1st postoperative month. The most common organisms responsible for shunt infection include coagulase-negative Staphylococcus and Staphylococcus aureus. This suggests a transfer of Patient's skin flora via the surgeons' glove as a possible means of infection. The authors conducted a study to determine if the rate of postoperative shunt infections could be reduced simply by changing gloves before handling the shunt catheter. Methods: A total of 111 neonates born with congenital hydrocephalus …
Vertex And The New Wave Of Huntington’S Research,
2010
University of San Diego
Vertex And The New Wave Of Huntington’S Research, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Globalizing The Fight Against Huntington's,
2010
University of San Diego
Globalizing The Fight Against Huntington's, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
The Mglur2/3 Agonist Ly397268 Improves Morphometric And Behavioral Outcomes In R6/2 Huntington's Disease Mice,
2010
University of Tennessee Health Science Center
The Mglur2/3 Agonist Ly397268 Improves Morphometric And Behavioral Outcomes In R6/2 Huntington's Disease Mice, Dennis Craig Lafferty
Theses and Dissertations (ETD)
A prominent theory for the pathology of Huntington's Disease (HD) is the excitotoxic injury to the striatum. Continual exposure of ionotropic NMDA receptors to glutamate from the cortex can be excitotoxic in HD and leave striatal neurons vulnerable to damage. Activation of presynaptic mGluR2/3 by an agonist dampens glutamate release from corticostriatal terminals. Treatments that target excitoxicity and oxidative stress thus may improve some of the symptoms in HD patients and it is therefore logical to pursue therapies aimed in this direction. LY379268 is an inviting mGluR2/3 agonist that has been shown to be neuroprotective in hypoxic and ischemic injuries …
Donepezil And Galanin Interactions In An Animal Model Of Alzheimer’S Disease,
2010
University of Nevada, Las Vegas
Donepezil And Galanin Interactions In An Animal Model Of Alzheimer’S Disease, Jonathan J. Sabbagh
UNLV Theses, Dissertations, Professional Papers, and Capstones
Alzheimer's disease (AD) is a neurodegenerative disorder marked by a progressive loss of cognitive function. One of the neurobiological hallmarks of AD is a progressive loss of cholinergic neurons and a decrease in the amount of acetylcholine in the brain. Pharmacological therapies have targeted the cholinergic system, specifically first-line, palliative treatment using acetylcholinesterase (AChE) inhibitors, such as donepezil. Donepezil has been shown to increase cholinergic tone and ameliorate some of the cognitive deficits in AD patients. Galanin, a neuropeptide that inhibits the evoked release of several neurotransmitters including acetylcholine as well as modulates seveal intracellular cascades, is overexpressed in AD …
Enjoying The Life We Have Left,
2010
University of San Diego
Enjoying The Life We Have Left, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
An Expedition To The Brain,
2010
University of San Diego
An Expedition To The Brain, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
