Hope, Cutting-Edge Science, And Poignant Moments At The World Congress On Huntington's Disease, 2013 University of San Diego
Hope, Cutting-Edge Science, And Poignant Moments At The World Congress On Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Reaching Out To The ‘Hd Family’ At The World Congress On Huntington's Disease, 2013 University of San Diego
Reaching Out To The ‘Hd Family’ At The World Congress On Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Heading To Rio For The 2013 World Congress On Huntington's Disease, 2013 University of San Diego
Heading To Rio For The 2013 World Congress On Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Advocacy Meets Science And Medicine: Personal Enrichment And A Coping Mechanism For Huntington's Disease, 2013 University of San Diego
Advocacy Meets Science And Medicine: Personal Enrichment And A Coping Mechanism For Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
‘Predicting’ Huntington’S Disease In The Heartland, 2013 University of San Diego
‘Predicting’ Huntington’S Disease In The Heartland, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
A Gene-Positive Dad’S Reflections On Huntington’S Disease, Parenthood, And The Fragility Of Life, 2013 University of San Diego
A Gene-Positive Dad’S Reflections On Huntington’S Disease, Parenthood, And The Fragility Of Life, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
"Who Would Have Thought, With A Diagnosis Like This, I Would Be Happy?": Portraits Of Perceived Strengths And Resources In Early-Stage Dementia, 2013 Portland State University
"Who Would Have Thought, With A Diagnosis Like This, I Would Be Happy?": Portraits Of Perceived Strengths And Resources In Early-Stage Dementia, Jutta Elisabeth Ataie
Dissertations and Theses
This study used photovoice methodology to explore how people with early-stage dementia use their perceived strength and resources to cope with the illness. Purposive sampling was used to recruit participants. Thirteen women and seven men age 57 to 90 (mean 73.4) with MMSE scores ranging from 20 to 28 (mean 25.6) participated in the project. Participants were provided with a disposable camera and invited to take photographs relevant to their well-being. The photographs provided the means for participants to take the lead in dialogue sessions about their coping response.
Grounded theory analysis revealed that initially, early-stage dementia precipitated a disruption …
Depression In Parkinson Disease, 2013 Washington University School of Medicine
Depression In Parkinson Disease, Kevin J. Black
Kevin J. Black, MD
Statin Discontinuation Among Nursing Home Residents With Advanced Dementia, 2013 University of Massachusetts Medical School
Statin Discontinuation Among Nursing Home Residents With Advanced Dementia, Jennifer Tjia, Sarah L. Cutrona, Daniel J. Peterson, Becky A. Briesacher
Jennifer Tjia
Background: Statin use in elderly individuals with life-limiting illness such as advanced dementia is controversial.
Objective: To describe factors associated with statin discontinuation and estimate impact of discontinuation on 28-day hospitalizations in nursing home (NH) residents with advanced dementia.
Methods: Retrospective cohort study of NH residents ≥ 65 years with recent progression to advanced dementia from 5 large U.S. states drawn from the 2007-2008 Minimum Data Set 2.0. We identified residents using statins. Clinical characteristics and 28-day hospitalization risk were compared for residents discontinuing and continuing statins. Multivariable Cox proportional hazard models identified factors associated with time to statin discontinuation …
Going With The Flow Of Time, 2013 University of San Diego
Going With The Flow Of Time, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Magnetic Resonance Imaging Of Iron In Early Multiple Sclerosis At 3 Tesla, 2013 The University of Western Ontario
Magnetic Resonance Imaging Of Iron In Early Multiple Sclerosis At 3 Tesla, Matthew P. Quinn
Electronic Thesis and Dissertation Repository
Multiple sclerosis (MS) is the most common neurological disease in young Canadians, yet its etiology remains obscure. Two possibly related findings in MS are brain iron deposition and the presence of small veins in white matter lesions. This thesis concerns the development and application of 3 Tesla magnetic resonance imaging tools to image iron and veins in early multiple sclerosis.
To facilitate measurements of iron concentration as well as production of cerebral venograms, we first optimized multi-echo susceptibility weighted imaging (SWI), using numerical simulations and input from physicians. We validated measurements of R2*, an MRI parameter that scales linearly with …
Exploring The Iranian-Canadian Family Experience Of Dementia Caregiving: A Phenomenological Study, 2013 The University of Western Ontario
Exploring The Iranian-Canadian Family Experience Of Dementia Caregiving: A Phenomenological Study, Sevil Deljavan
Electronic Thesis and Dissertation Repository
Presently in Canada, there are approximately 500,000 individuals living with dementia, which is expected to increase to over one million by 2038. With Canada’s minority elderly population growing, the number of Iranian-Canadian older adults living with dementia is expected to rise as well. Family caregivers are a significant source of help among Iranian-Canadians and the provision of informal care by adult children for parents with dementia in the Iranian culture is an expression of love and dedication.
This study explored the meaning of the experience of Iranian adult children in Canada caring for a parent with Alzheimer’s disease, the values …
Spatial Reorganization Of Putaminal Dopamine D2-Like Receptors In Cranial And Hand Dystonia, 2013 Washington University School of Medicine in St. Louis
Spatial Reorganization Of Putaminal Dopamine D2-Like Receptors In Cranial And Hand Dystonia, Kevin J. Black, Abraham Z. Snyder, Jonathan W. Mink, Veeral N. Tolia, Fredy J. Revilla, Stephen M. Moerlein, Joel S. Perlmutter
Kevin J. Black, MD
No abstract provided.
Fighting For The Option To Care For Huntington’S Disease Patients At Home, 2013 University of San Diego
Fighting For The Option To Care For Huntington’S Disease Patients At Home, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Amyloid Beta Resistance And The Warburg Effect: Re-Examining Alzheimer's Disease, 2013 The University of Western Ontario
Amyloid Beta Resistance And The Warburg Effect: Re-Examining Alzheimer's Disease, Jordan Taylor Newington
Electronic Thesis and Dissertation Repository
Alzheimer’s disease (AD) is characterized by deposition of the amyloid beta (Ab) peptide in the brain, an event which frequently but not universally correlates with nerve cell death. Although most nerve cells die in response to Ab, small populations of cells are able to survive by becoming resistant to Ab toxicity. Understanding the mechanisms by which cells become resistant to Ab may reveal novel treatments for AD. Interestingly, nerve cell lines selected for resistance against Ab exhibit increased glucose uptake and glycolytic flux. Here I show that these metabolic changes are mediated through an upregulation of pyruvate dehydrogenase kinase 1 …
Expression Of The Chemokine Receptor, Cxcr4, And Its Ligand, Sdf-1, Are Increased In Purkinje Cells Of The Multiple System Atrophy Cerebellum, 2013 Western Michigan University
Expression Of The Chemokine Receptor, Cxcr4, And Its Ligand, Sdf-1, Are Increased In Purkinje Cells Of The Multiple System Atrophy Cerebellum, Megan Welter
Masters Theses
Multiple System Atrophy (MSA) is a sporadic, neurodegenerative disease that consists of three conditions: autonomic dysfunction, Parkinsonism and cerebellar ataxia. Our lab conducted an Affymetrix global gene expression analysis using pons tissue of MSA patients to determine genes that are differentially expressed when compared to non- MSA controls. This study identified upregulated genes, including the C-X-C chemokine receptor type 4, CXCR4, to which stromal cell-derived factor-I (SDF-1) is the natural ligand. The CXCR4/SDF-1 signaling pair has been sho.wn to play multiple roles in the brain, such as inducing neuronal apoptosis and promoting leukocyte recruitment during inflammation. The MSA cerebellum presents …
Diabetes Mellitus And Hypercholesterolemia Are Risk Factors For Alzheimer’S Disease And Appear To Affect The Integrity Of The Blood Brain Barrier, 2013 Rowan University
Diabetes Mellitus And Hypercholesterolemia Are Risk Factors For Alzheimer’S Disease And Appear To Affect The Integrity Of The Blood Brain Barrier, Jacqueline Dash
Graduate School of Biomedical Sciences Theses and Dissertations
Studies have shown that the vascular risk factors common to diabetes mellitus and hypercholesterolemia are also risk factors for Alzheimer’s disease (AD). It is currently unknown how these diseases are associated with AD, but they may cause a leak in the blood brain barrier (BBB), which is one of the hallmarks of AD. In this preliminary study, over 150 pig brain slides were tested for the expression levels of tight junction proteins occludin and claudin V in the BBB microvasculature. There were three groups of pig brains used in this study namely, control pigs, pigs with diabetes mellitus and hypercholesterolemia …
A Descriptive Study To Find Possible Correlation Between Mri Findings Of Pituitary Gland And Serum Prolactin Level, 2013 Aga Khan University
A Descriptive Study To Find Possible Correlation Between Mri Findings Of Pituitary Gland And Serum Prolactin Level, Muhammad Azeemuddin, Rohana Naqi, Mohammad Wasay
Department of Medicine
Objective: To explore equation, if any, between findings of magnetic resonance imaging of pituitary gland and serum prolactin level.
Methods: The retrospective, descriptive study was conducted at the Department of Radiology, Aga Khan University Hospital, Karachi, and related to patients\' records from April 19, 2006 to April 23, 2009. Seventy patients underwent magnetic resonance imaging of brain for pituitary gland. Inclusion criteria were all patients referred with relevant clinical symptoms or deranged serum prolactin level. Patients who were claustrophobic or had a pacemaker, aneurysm clip, metallic foreign body in the orbit or with no laboratory investigation were excluded from the …
Strangling Of Patient In Nursing Home A Shuddering Reminder Of Subpar Care For Huntington's Disease, 2013 University of San Diego
Strangling Of Patient In Nursing Home A Shuddering Reminder Of Subpar Care For Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Do We Need To Shock The World To Strengthen The Huntington's Disease Cause, 2013 University of San Diego
Do We Need To Shock The World To Strengthen The Huntington's Disease Cause, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.