It’S Playoff Time – And A Reminder That Brain Health Comes First,
2013
University of San Diego
It’S Playoff Time – And A Reminder That Brain Health Comes First, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Creating A Christmas Memory For A Huntington’S Family,
2013
University of San Diego
Creating A Christmas Memory For A Huntington’S Family, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
‘Alive And Well’ Captures Struggle Against Untreatable Brain Disorder,
2013
University of San Diego
‘Alive And Well’ Captures Struggle Against Untreatable Brain Disorder, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Exploring The Structure And Biochemistry Of Oxidation-Mediated Inhibitation Of The Peptidyl-Prolyl Isomerase Pin1,
2013
The University of Western Ontario
Exploring The Structure And Biochemistry Of Oxidation-Mediated Inhibitation Of The Peptidyl-Prolyl Isomerase Pin1, Brendan T. Innes
Electronic Thesis and Dissertation Repository
Pin1 is a phosphorylation-dependent peptidyl-prolyl isomerase that has been shown to be neuroprotective in aging-related neurodegenerative diseases such as Alzheimer's disease (AD). However, it is not active in AD brain, and a recent proteomic screen of Mild Cognitive Impairment (MCI) brain samples revealed that Pin1 is oxidized in the brains of these pre-AD patients. This suggests that this oxidation may be the cause of the loss of the neuroprotective Pin1 function in AD. The Pin1 active site contains a functionally critical cysteine residue (Cys113) with a low predicted pKa, making it highly susceptible to oxidation. We hypothesize that Pin1 is …
The Cell And Molecular Biology Of Neurodegenerative Diseases: An Overview,
2013
Philadelphia College of Osteopathic Medicine
The Cell And Molecular Biology Of Neurodegenerative Diseases: An Overview, Heather L. Montie, Thomas M. Durcan
PCOM Scholarly Papers
There is no abstract for this article.
A Huntington’S Thanksgiving Message: Gratitude For Health And The Ability To Work,
2013
University of San Diego
A Huntington’S Thanksgiving Message: Gratitude For Health And The Ability To Work, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Braving Bioethical Challenges: The Importance Of Huntington's Disease,
2013
University of San Diego
Braving Bioethical Challenges: The Importance Of Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
One Year Out Of The Terrible, Lonely Huntington’S Disease Closet,
2013
University of San Diego
One Year Out Of The Terrible, Lonely Huntington’S Disease Closet, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Diagnosis, Treatment And Follow-Up In Four Children With Biotinidase Deficiency From Pakistan,
2013
Aga Khan University
Diagnosis, Treatment And Follow-Up In Four Children With Biotinidase Deficiency From Pakistan, Bushra Afroze, Mohammad Wasay
Department of Medicine
Biotinidase deficiency is an inherited disorder in which the vitamin biotin is not recycled. If untreated, affected individuals develop neurological and cutaneous symptoms. Untreated individuals with biotinidase deficiency either succumb to disease or are left with significant morbidity. We describe clinical course and follow-up of 4 children from Pakistan. All 4 presented with classical symptoms of biotinidase deficiency and responded dramatically to oral biotin within days to weeks. Biotinidase deficiency is reported in Pakistani children from different part of world, however; there is no such report from Pakistan. This highlights lack of awareness of biotinidase deficiency among physicians in Pakistan
‘Tired Of Waiting,’ Huntington’S Disease Families Engrossed In Efforts To Conduct Clinical Trials,
2013
University of San Diego
‘Tired Of Waiting,’ Huntington’S Disease Families Engrossed In Efforts To Conduct Clinical Trials, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
The End Of Fear And Exclusion: Informing My Health Insurance Plan About The Risk Of Huntington's Disease,
2013
University of San Diego
The End Of Fear And Exclusion: Informing My Health Insurance Plan About The Risk Of Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Hope, Cutting-Edge Science, And Poignant Moments At The World Congress On Huntington's Disease,
2013
University of San Diego
Hope, Cutting-Edge Science, And Poignant Moments At The World Congress On Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Reaching Out To The ‘Hd Family’ At The World Congress On Huntington's Disease,
2013
University of San Diego
Reaching Out To The ‘Hd Family’ At The World Congress On Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Heading To Rio For The 2013 World Congress On Huntington's Disease,
2013
University of San Diego
Heading To Rio For The 2013 World Congress On Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Advocacy Meets Science And Medicine: Personal Enrichment And A Coping Mechanism For Huntington's Disease,
2013
University of San Diego
Advocacy Meets Science And Medicine: Personal Enrichment And A Coping Mechanism For Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
‘Predicting’ Huntington’S Disease In The Heartland,
2013
University of San Diego
‘Predicting’ Huntington’S Disease In The Heartland, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
A Gene-Positive Dad’S Reflections On Huntington’S Disease, Parenthood, And The Fragility Of Life,
2013
University of San Diego
A Gene-Positive Dad’S Reflections On Huntington’S Disease, Parenthood, And The Fragility Of Life, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
"Who Would Have Thought, With A Diagnosis Like This, I Would Be Happy?": Portraits Of Perceived Strengths And Resources In Early-Stage Dementia,
2013
Portland State University
"Who Would Have Thought, With A Diagnosis Like This, I Would Be Happy?": Portraits Of Perceived Strengths And Resources In Early-Stage Dementia, Jutta Elisabeth Ataie
Dissertations and Theses
This study used photovoice methodology to explore how people with early-stage dementia use their perceived strength and resources to cope with the illness. Purposive sampling was used to recruit participants. Thirteen women and seven men age 57 to 90 (mean 73.4) with MMSE scores ranging from 20 to 28 (mean 25.6) participated in the project. Participants were provided with a disposable camera and invited to take photographs relevant to their well-being. The photographs provided the means for participants to take the lead in dialogue sessions about their coping response.
Grounded theory analysis revealed that initially, early-stage dementia precipitated a disruption …
Depression In Parkinson Disease,
2013
Washington University School of Medicine
Depression In Parkinson Disease, Kevin J. Black
Kevin J. Black, MD
Statin Discontinuation Among Nursing Home Residents With Advanced Dementia,
2013
University of Massachusetts Medical School
Statin Discontinuation Among Nursing Home Residents With Advanced Dementia, Jennifer Tjia, Sarah L. Cutrona, Daniel J. Peterson, Becky A. Briesacher
Jennifer Tjia
Background: Statin use in elderly individuals with life-limiting illness such as advanced dementia is controversial.
Objective: To describe factors associated with statin discontinuation and estimate impact of discontinuation on 28-day hospitalizations in nursing home (NH) residents with advanced dementia.
Methods: Retrospective cohort study of NH residents ≥ 65 years with recent progression to advanced dementia from 5 large U.S. states drawn from the 2007-2008 Minimum Data Set 2.0. We identified residents using statins. Clinical characteristics and 28-day hospitalization risk were compared for residents discontinuing and continuing statins. Multivariable Cox proportional hazard models identified factors associated with time to statin discontinuation …
