The Reversal Effects Of Curcumin, An Herbal Remedy, On The Impairments Induced By Vmat-2 Inhibitor Tetrabenazine,
2014
University of Connecticut - Storrs
The Reversal Effects Of Curcumin, An Herbal Remedy, On The Impairments Induced By Vmat-2 Inhibitor Tetrabenazine, Emily Qian, Samantha E. Yohn
Honors Scholar Theses
Substantial evidence has shown that dopamine (DA), particularly in the nucleus accumbens (NAc), is involved in behavioral activation and effort-related processes, such as overcoming work related response costs. Interference with accumbens DA transmission through administration of the vesicular monoamine transportor-2 (VMAT-2) inhibitor tetrabenazine (TBZ) produces an alteration of response allocation in the concurrent FR5/chow choice procedure, biasing animals toward the lower effort alternative. It has been suggested that these drug-induced shifts in effort-related choice behavior seen in rodents are analogous to symptoms such as psychomotor retardation, anergia, and fatigue, which can be observed in people with depression and other related …
Visions Of Living With Parkinson's Disease: A Photovoice Study,
2014
The University of Texas at Tyler
Visions Of Living With Parkinson's Disease: A Photovoice Study, Danice Greer, Cheryl Cooper, Melinda Hermanns
Faculty Posters
This poster was presented at the May 2014 UT Tyler Faculty Awards.
Propagation Of Oligomeric Α-Synuclein And Amyloid-Β: Implications For Parkinson's And Alzheimer's Diseases,
2014
University of Southern Mississippi
Propagation Of Oligomeric Α-Synuclein And Amyloid-Β: Implications For Parkinson's And Alzheimer's Diseases, Matthew Stephen Planchard
Master's Theses
The aggregation of amyloidogenic proteins is a critical event in the pathology of a variety of neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). The proteins α-synuclein (αS) and amyloid-β (Aβ) are involved in the formation of amyloid lesions observed in PD and AD, respectively. Both PD and AD exhibit a significant amount of co-pathology in clinical settings, and the αS and Aβ proteins have been shown to interact in vitro. Recent experimental consensus has shown oligomeric species to be significant, if not primary, sources of toxicity in these diseases. …
Epigenetic Remodeling In An Imr-32 Cell Line And Transgenic Mouse Model Of Alzheimer's Disease,
2014
Liberty University
Epigenetic Remodeling In An Imr-32 Cell Line And Transgenic Mouse Model Of Alzheimer's Disease, Matthew S. Baker
Senior Honors Theses
The pathological features of Alzheimer’s disease (AD) have been researched and documented extensively, however the causes of these features are still unknown. The following studies sought to determine if epigenetic methylation alterations contribute to AD. Two studies were sequentially carried out, first using an IMR-32 model and then using a transgenic mouse model overexpressing beta-amyloid. A few assay and confirmation methods were carried out to determine the promoter regions in disease state models undergoing drastic change, and the genes linked to these promoter regions were analyzed to determine significant gene ontology being altered by this epigenetic modification. This data was …
After A Social Security Setback, Hdsa Steps Up Advocacy On Huntington's Disability Criteria,
2014
University of San Diego
After A Social Security Setback, Hdsa Steps Up Advocacy On Huntington's Disability Criteria, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Role Of Gluk1 Kainate Receptors In Seizures, Epileptic Discharges, And Epileptogenesis,
2014
Drexel University
Role Of Gluk1 Kainate Receptors In Seizures, Epileptic Discharges, And Epileptogenesis, Brita Fritsch, Janine Reis, Maciej Gasior, Rafal M. Kaminski, Michael A. Rogawski
Michael A. Rogawski
Kainate receptors containing the GluK1 subunit have an impact on excitatory and inhibitory neurotransmission in brain regions, such as the amygdala and hippocampus, which are relevant to seizures and epilepsy. Here we used 2-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl) propanoic acid (ATPA), a potent and selective agonist of kainate receptors that include the GluK1 subunit, in conjunction with mice deficient in GluK1 and GluK2 kainate receptor subunits to assess the role of GluK1 kainate receptors in provoking seizures and in kindling epileptogenesis. We found that systemic ATPA, acting specifically via GluK1 kainate receptors, causes locomotor arrest and forelimb extension (a unique behavioral characteristic of GluK1 …
Role Of Gluk1 Kainate Receptors In Seizures, Epileptic Discharges, And Epileptogenesis,
2014
Drexel University
Role Of Gluk1 Kainate Receptors In Seizures, Epileptic Discharges, And Epileptogenesis, Brita Fritsch, Janine Reis, Maciej Gasior, Rafal M. Kaminski, Michael A. Rogawski
Michael A. Rogawski
Kainate receptors containing the GluK1 subunit have an impact on excitatory and inhibitory neurotransmission in brain regions, such as the amygdala and hippocampus, which are relevant to seizures and epilepsy. Here we used 2-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl) propanoic acid (ATPA), a potent and selective agonist of kainate receptors that include the GluK1 subunit, in conjunction with mice deficient in GluK1 and GluK2 kainate receptor subunits to assess the role of GluK1 kainate receptors in provoking seizures and in kindling epileptogenesis. We found that systemic ATPA, acting specifically via GluK1 kainate receptors, causes locomotor arrest and forelimb extension (a unique behavioral characteristic of GluK1 …
Woody Guthrie, Huntington’S Disease, And Our Duty To Improve Caregiving,
2014
University of San Diego
Woody Guthrie, Huntington’S Disease, And Our Duty To Improve Caregiving, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Reshaping My Career And Life In The Face Of Huntington's Disease (And A Note Of Hope),
2014
University of San Diego
Reshaping My Career And Life In The Face Of Huntington's Disease (And A Note Of Hope), Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Development Of A Safe And Efficient Near-Infrared Diagnostic Method For Alzheimer's Disease,
2014
Georgia State University
Development Of A Safe And Efficient Near-Infrared Diagnostic Method For Alzheimer's Disease, Joseph Tawney
Georgia State Undergraduate Research Conference
No abstract provided.
Uncovering The Evidence: Systematic Review Of Interventions To Reduce Oral Health Disparities Between Adults With Intellectual Disability And The General Population,
2014
University of Massachusetts Medical School
Uncovering The Evidence: Systematic Review Of Interventions To Reduce Oral Health Disparities Between Adults With Intellectual Disability And The General Population, Christine J. Clifford, Alexandra Bonardi, Nancy E. Harger, Matthew Holder
Nancy E. Harger
Oral health is a public health concern for people with intellectual or developmental disabilities (I/DD). Research consistently shows that the population with I/DD experiences poorer oral hygiene, higher prevalence and severity of periodontal disease, and higher incidence of untreated caries when compared to the general population. Poor oral health can cause chronic pain, affect the ability to eat and communicate, and adversely affect physical health and quality of life. Intervention strategies include enhanced prevention, increased routine care, expanded insurance coverage, and training for dentists and hygienists. Research is needed to identify the most effective interventions. A standard systematic literature review …
Brain Blast 2014 Speakers Poster,
2014
University of New England
Brain Blast 2014 Speakers Poster, Annie Leslie
Brain Blast
Poster from UNE's Brain Blast 2014 listing the presenters at this event.
Brain Blast 2014 Poster,
2014
University of New England
Brain Blast 2014 Poster, Annie Leslie
Brain Blast
Announcement poster for UNE's Brain Blast 2014, a pechakucha-style brain health and safety awareness and learning event.
Health, Wellness, And The Pursuit Of Happiness: Common Ground For Adults With Cerebral Palsy And Modern Physical Therapists,
2014
University of Hartford
Health, Wellness, And The Pursuit Of Happiness: Common Ground For Adults With Cerebral Palsy And Modern Physical Therapists, Lisa Blumberg, Mary E. Gannotti, Diana J. Larocco, Yvette Blanchard
Physical Therapy Faculty Publications
Health, wellness, and happiness are important long-term goals for adulthood, especially for children with cerebral palsy (CP). Physical therapists (PTs) can assist individuals with CP realize these goals; however it requires PTs to have a greater understanding of how to apply impairment, functional, or contextual interventions to meet these goals. A critical gap in knowledge exists about perceptions of happiness and health priorities of adults with CP. The purpose of this paper is to describe the beliefs, feelings, and perceptions of happiness and health of adults with CP as compared to adults without CP, specifically PTs.
What’S In A Name? How Huntington’S Disease Gene Carriers Are Seen By Themselves And Others,
2014
University of San Diego
What’S In A Name? How Huntington’S Disease Gene Carriers Are Seen By Themselves And Others, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
‘It’S Really Getting Real’: Payoffs In The Effort To Treat Huntington's Disease,
2014
University of San Diego
‘It’S Really Getting Real’: Payoffs In The Effort To Treat Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Accentuating The Positive: Olympic Medalist Sarah Winckless's Strategy Against Huntington's Disease,
2014
University of San Diego
Accentuating The Positive: Olympic Medalist Sarah Winckless's Strategy Against Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Attention Deficit Associated With Early Life Interictal Spikes In A Rat Model Is Improved With Acth,
2014
Dartmouth College
Attention Deficit Associated With Early Life Interictal Spikes In A Rat Model Is Improved With Acth, Amanda E. Hernan, Abigail Alexander, Pierre-Pascal Lenck-Santini, Rod C. Scott
Dartmouth Scholarship
Children with epilepsy often present with pervasive cognitive and behavioral comorbidities including working memory impairments, attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder. These non-seizure characteristics are severely detrimental to overall quality of life. Some of these children, particularly those with epilepsies classified as Landau-Kleffner Syndrome or continuous spike and wave during sleep, have infrequent seizure activity but frequent focal epileptiform activity. This frequent epileptiform activity is thought to be detrimental to cognitive development; however, it is also possible that these IIS events initiate pathophysiological pathways in the developing brain that may be independently associated with cognitive deficits. These …
To Take, Or Not To Take, Unproven Supplements In The Fight Against Huntington's Disease,
2014
University of San Diego
To Take, Or Not To Take, Unproven Supplements In The Fight Against Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Proof Of Heaven? My Ongoing Search For The Meaning Of Huntington's Disease In Life And Death,
2014
University of San Diego
Proof Of Heaven? My Ongoing Search For The Meaning Of Huntington's Disease In Life And Death, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
