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1,872 full-text articles. Page 80 of 85.

Who Listens To Our Advice? A Secondary Analysis Of Data From A Clinical Trial Testing An Intervention Designed To Decrease Delay In Seeking Treatment For Acute Coronary Syndrome, Barbara Riegel, Angelo Elmi, Debra K. Moser, Sharon McKinley, Hendricka Meischke, Lynn V. Doering, Patricia Davidson, Michele Pelter, Heather Baker, Kathleen Dracup 2011 University of Pennsylvania

Who Listens To Our Advice? A Secondary Analysis Of Data From A Clinical Trial Testing An Intervention Designed To Decrease Delay In Seeking Treatment For Acute Coronary Syndrome, Barbara Riegel, Angelo Elmi, Debra K. Moser, Sharon Mckinley, Hendricka Meischke, Lynn V. Doering, Patricia Davidson, Michele Pelter, Heather Baker, Kathleen Dracup

School of Nursing Departmental Papers

Objective

Prolonged prehospital delay in persons experiencing acute coronary syndrome (ACS) remains a problem. Understanding which patients respond best to particular interventions designed to decrease delay time would provide mechanistic insights into the process by which interventions work.

Methods

In the PROMOTION trial, 3522 at-risk patients were enrolled from 5 sites in the United States (56.4%), Australia and New Zealand; 490 (N = 272 intervention, N = 218 control) had an acute event within 2 years. Focusing on these 490, we (1) identified predictors of a rapid response to symptoms, (2) identified intervention group subjects with a change in these predictors ...


Long-Term Trends In Short-Term Outcomes In Acute Myocardial Infarction, Hoa Nguyen, Jane Saczynski, Joel Gore, Molly Waring, Darleen Lessard, Jorge Yarzebski, George Reed, Frederick Spencer, Shu-Xia Li, Robert Goldberg 2011 University of Massachusetts Medical School

Long-Term Trends In Short-Term Outcomes In Acute Myocardial Infarction, Hoa Nguyen, Jane Saczynski, Joel Gore, Molly Waring, Darleen Lessard, Jorge Yarzebski, George Reed, Frederick Spencer, Shu-Xia Li, Robert Goldberg

Jorge L. Yarzebski

BACKGROUND: The objectives of this study were to examine the magnitude of, and 20-year trends in, age differences in short-term outcomes among men and women hospitalized with acute myocardial infarction (AMI) in central Massachusetts.

METHODS: The study population consisted of 5907 male and 4406 female residents of the Worcester, MA, metropolitan area hospitalized at all greater Worcester medical centers with AMI between 1986 and 2005.

RESULTS: Overall, among both men and women, older patients were significantly more likely to have developed atrial fibrillation, heart failure, and to have died during hospitalization and within 30 days after admission compared with patients ...


A Reappraisal Of Stroke Mortality Trends In Brazil (1979 To 2009), Paulo A. Lotufo 2011 Universidade de São Paulo

A Reappraisal Of Stroke Mortality Trends In Brazil (1979 To 2009), Paulo A. Lotufo

Paulo A Lotufo

Background: Brazil has the highest cerebrovascular death rate in the Western Hemisphere. We investigated temporal trends according to gender and stroke subtypes. Methods: We analysed mortality rates between 1979 and 2009 for different stroke subtypes. Data were stratified by sex and age (35–74 y). The annual percent change (APC) and significant changes in the trends were identified with joinpoint Poisson regression. The average annual percent change (AAPC) for 2005-09 was presented because that period had the best quality of information. Results: After excluding deaths due to stroke sequels, for men, the APCs (95% confidence intervals) were: 1979-84: 0.7 ...


Autoimmune Responses To Atherosclerotic Lipids: A Study In Murine Models Of Atherosclerosis And Obesity, hanjing wu 2011 The Texas Medical Center Library

Autoimmune Responses To Atherosclerotic Lipids: A Study In Murine Models Of Atherosclerosis And Obesity, Hanjing Wu

The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Dissertations and Theses (Open Access)

Atherosclerosis is a chronic, complex arterial disease characterized by intimal lipid accumulation and inflammation. A unique lipid-binding molecule, namely cluster of differentiation 1d (CD1d), may impact atherosclerosis. Structurally, CD1d acts as a nonpolymorphic cell-surface receptor, resembling the major histocompatibility complex-I (MHC-I). While MHC-I restricts peptide antigen presentation to T cells, CD1d presents lipid antigens to T cells named CD1d-restrictedd T cells. Although increased expression of CD1d has been found in human plaques, the exact nature of CD1d-recognized lipids in atherosclerosis remains to be determined. Three groups of lipids may undergo oxidation in atherosclerosis producing atherogenic lipids: phospholipids, fatty acids, and ...


The Impact Of Frailty On Health Related Quality Of Life In Heart Failure, Harleah G. Buck, Barbara Riegel 2011 University of Pennsylvania

The Impact Of Frailty On Health Related Quality Of Life In Heart Failure, Harleah G. Buck, Barbara Riegel

School of Nursing Departmental Papers

Background/Aims: Most heart failure (HF) hospital discharges involve people > 65 years, many frail. The purpose of this study was to determine if frailty explains variability in health related quality of life (HRQOL) in older adults with HF over and above known correlates.

Methods: A frailty index score was developed by weighting age, number of comorbid conditions, and symptom severity. A multivariate hierarchical regression analysis of known predictors of HRQOLgender, income, ethnicity, health perception, NYHA class — were entered first and then the frailty index was entered and regressed on HRQOL in 2 unique samples.

Results: When known predictors were tested ...


Early Detection And Treatment Of Acute Clinical Decline In Hospitalized Patients: An Observational Study Of Icu Transfers And An Assessment Of The Effectiveness Of A Rapid Response Program: A Dissertation, Tanya Lord 2011 University of Massachusetts Medical School

Early Detection And Treatment Of Acute Clinical Decline In Hospitalized Patients: An Observational Study Of Icu Transfers And An Assessment Of The Effectiveness Of A Rapid Response Program: A Dissertation, Tanya Lord

GSBS Dissertations and Theses

The Institute for Healthcare Improvement (IHI) has promoted implementing a RRS to provide safer care for hospitalized patients. Additionally, the Joint Commission made implementing a RRS a 2008 National Patient Safety Goal. Although mandated, the evidence to support the effectiveness of a RRS to reduce cardiac arrests on hospital medical or surgical floors and un-anticipated ICU transfers remains inconclusive, partly because of weak study designs and partly due to a failure of published studies to report all critical aspects of their intervention. This study attempted to evaluate the effectiveness and the implementation of a RRS on the two campuses of ...


Transcendocardinal Delivery Of Aav6 Results In Highly Efficient And Global Cardiac Gene Transfer In Rhesus Macaques, Guangping Gao, Lawrence T. Bish, Margaret M. Sleeper, Xin Mu, Lan Sun, You Lou, Jiachuan Duan, Chunyan Hu, Li Wang, H. Lee Sweeney 2011 University of Pennsylvania

Transcendocardinal Delivery Of Aav6 Results In Highly Efficient And Global Cardiac Gene Transfer In Rhesus Macaques, Guangping Gao, Lawrence T. Bish, Margaret M. Sleeper, Xin Mu, Lan Sun, You Lou, Jiachuan Duan, Chunyan Hu, Li Wang, H. Lee Sweeney

Departmental Papers (Vet)

Heart disease is the leading cause of morbidity and mortality, and cardiac gene transfer has potential as a novel therapeutic approach. We previously demonstrated safe and efficient gene transfer to the canine heart using a percutaneous transendocardial injection procedure to deliver self-complementary (sc) adeno-associated virus 6 (AAV6) vector. In the present study, we proceed with our vertical translation study to evaluate cardiac gene transfer in nonhuman primates (NHPs). We screened approximately 30 adult male rhesus macaques for the presence of neutralizing antibodies against AAV6, AAV8, and AAV9, and then selected seven monkeys whose antibody titers against these three serotypes were ...


Neighborhood Disparities In Stroke And Myocardial Infarction Mortality: A Gis And Spatial Scan Statistics Approach, Agricola Odoi 2011 University of Tennessee, Knoxville

Neighborhood Disparities In Stroke And Myocardial Infarction Mortality: A Gis And Spatial Scan Statistics Approach, Agricola Odoi

Agricola Odoi

Background: Stroke and myocardial infarction (MI) are serious public health burdens in the US. These burdens vary by geographic location with the highest mortality risks reported in the southeastern US. While these disparities have been investigated at state and county levels, little is known regarding disparities in risk at lower levels of geography, such as neighborhoods. Therefore, the objective of this study was to investigate spatial patterns of stroke and MI mortality risks in the East Tennessee Appalachian Region so as to identify neighborhoods with the highest risks. Methods: Stroke and MI mortality data for the period 1999-2007, obtained free ...


Neighborhood Disparities In Stroke And Myocardial Infarction Mortality: A Gis And Spatial Scan Statistics Approach, Ashley Pedigo, Tim Aldrich, Agricola Odoi 2011 University of Tennessee - Knoxville

Neighborhood Disparities In Stroke And Myocardial Infarction Mortality: A Gis And Spatial Scan Statistics Approach, Ashley Pedigo, Tim Aldrich, Agricola Odoi

Faculty Publications and Other Works -- UT Graduate School of Medicine

Background

Stroke and myocardial infarction (MI) are serious public health burdens in the US. These burdens vary by geographic location with the highest mortality risks reported in the southeastern US. While these disparities have been investigated at state and county levels, little is known regarding disparities in risk at lower levels of geography, such as neighborhoods. Therefore, the objective of this study was to investigate spatial patterns of stroke and MI mortality risks in the East Tennessee Appalachian Region so as to identify neighborhoods with the highest risks.

Methods

Stroke and MI mortality data for the period 1999-2007, obtained free ...


Elucidating The Genetic Determinants Of The Archetypal Complex Disease Hypertriglyceridemia, Christopher T. Johansen 2011 University of Western Ontario

Elucidating The Genetic Determinants Of The Archetypal Complex Disease Hypertriglyceridemia, Christopher T. Johansen

Electronic Thesis and Dissertation Repository

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in Canada. Among non-traditional risk factors, plasma triglyceride (TG) concentration is re-emerging as a significant risk factor. Patients with hypertriglyceridemia (HTG) – an archetypal complex phenotype defined by fasting plasma TG concentration >95th percentile – thus have significantly increased CVD risk, compounded by associated co-morbidities such as obesity, metabolic syndrome and type 2 diabetes. However, the molecular pathways contributing to HTG susceptibility are incompletely defined. A better understanding of the genetic determinants that underlie the phenotypic spectrum of plasma TG and HTG susceptibility is necessary to identify novel genes and ...


Gene By Bmi Interactions Influencing C-Reactive Protein Levels In European-Americans, Sarah Tudor 2011 The University of Texas Graduate School of Biomedical Sciences at Houston

Gene By Bmi Interactions Influencing C-Reactive Protein Levels In European-Americans, Sarah Tudor

The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Dissertations and Theses (Open Access)

C-Reactive Protein (CRP) is a biomarker indicating tissue damage, inflammation, and infection. High-sensitivity CRP (hsCRP) is an emerging biomarker often used to estimate an individual’s risk for future coronary heart disease (CHD). hsCRP levels falling below 1.00 mg/l indicate a low risk for developing CHD, levels ranging between 1.00 mg/l and 3.00 mg/l indicate an elevated risk, and levels exceeding 3.00 mg/l indicate high risk. Multiple Genome-Wide Association Studies (GWAS) have identified a number of genetic polymorphisms which influence CRP levels. SNPs implicated in such studies have been found in or ...


Biomarkers Of Myocardial Stress And Systemic Inflammation In Patients Who Engage In Heart Failure Self-Care Management, Christopher S. Lee, Debra K. Moser, Terry A. Lennie, Nancy C. Tkacs, Kenneth B. Margulies, Barbara Riegel 2011 University of Pennsylvania

Biomarkers Of Myocardial Stress And Systemic Inflammation In Patients Who Engage In Heart Failure Self-Care Management, Christopher S. Lee, Debra K. Moser, Terry A. Lennie, Nancy C. Tkacs, Kenneth B. Margulies, Barbara Riegel

School of Nursing Departmental Papers

Background: Self-care is believed to improve heart failure (HF) outcomes, but the mechanisms by which such improvement occurs remain unclear.

Methods: We completed a secondary analysis of cross-sectional data collected on adults with symptomatic HF to test our hypothesis that effective self-care is associated with less myocardial stress and systemic inflammation. Multivariate logistic regression modeling was used to determine if better HF self-care reduced the odds of having serum levels of amino-terminal pro-B-type natriuretic peptide and soluble tumor necrosis factor α receptor type 1 at or greater than the sample median. Heart failure self-care was measured using the Self-care of ...


Use Of Multinational Registries To Assess And Compare Outcomes Of Patients With An Acute Coronary Syndrome: A Dissertation, Hamza H. Awad 2011 University of Massachusetts Medical School

Use Of Multinational Registries To Assess And Compare Outcomes Of Patients With An Acute Coronary Syndrome: A Dissertation, Hamza H. Awad

GSBS Dissertations and Theses

Background
Acute coronary syndromes (ACS) are a major cause of mortality and morbidity in the developed world. By 2020, ACS will be the leading cause of morbidity and mortality worldwide, largely due to substantial increases in ACS burden in developing countries. The developing world has been under-represented in international ACS registries. The Arabian Gulf area is a part of the developing world where little is known about the epidemiology of ACS. The first aim of the dissertation is to compare ACS patient characteristics, current practice patterns, and in-hospital outcomes in the Arabian Gulf area to a large multinational sample. Patients ...


Intracranial Atherosclerotic Disease, Maria Khan, Imama Naqvi, Asha Bansari, Ayeesha Kamran Kamal 2011 Aga Khan University

Intracranial Atherosclerotic Disease, Maria Khan, Imama Naqvi, Asha Bansari, Ayeesha Kamran Kamal

Department of Medicine

Intracranial atherosclerotic disease (ICAD) is the most common proximate mechanism of ischemic stroke worldwide. Approximately half of those affected are Asians. For diagnosis of ICAD, intra-arterial angiography is the gold standard to identify extent of stenosis. However, noninvasive techniques including transcranial ultrasound and MRA are now emerging as reliable modalities to exclude moderate to severe (50%-99%) stenosis. Little is known about measures for primary prevention of the disease. In terms of secondary prevention of stroke due to intracranial atherosclerotic stenosis, aspirin continues to be the preferred antiplatelet agent although clopidogrel along with aspirin has shown promise in the acute ...


Multiple Protein Kinases Determine The Phosphorylated State Of The Small Heat Shock Protein, Hsp27, In Sh-Sy5y Neuroblastoma Cells, Linda A. Dokas, Amy M. Malone, Frederick E. Williams, Surya M. Nauli, William S. Messer Jr. 2011 University of Toledo

Multiple Protein Kinases Determine The Phosphorylated State Of The Small Heat Shock Protein, Hsp27, In Sh-Sy5y Neuroblastoma Cells, Linda A. Dokas, Amy M. Malone, Frederick E. Williams, Surya M. Nauli, William S. Messer Jr.

Pharmacy Faculty Articles and Research

In SH-SY5Y human neuroblastoma cells, the cholinergic agonist, carbachol, stimulates phosphorylation of the small heat shock protein 27 (HSP27). Carbachol increases phosphorylation of both Ser-82 and Ser-78 while the phorbol ester, phorbol-12, 13-dibutyrate (PDB) affects only Ser-82. Muscarinic receptor activation by carbachol was confirmed by sensitivity of Ser-82 phosphorylation to hyoscyamine with no effect of nicotine or bradykinin. This response to carbachol is partially reduced by inhibition of protein kinase C (PKC) with GF 109203X and p38 mitogen-activated protein kinase (MAPK) with SB 203580. In contrast, phosphorylation produced by PDB is completely reversed by GF 109203X or CID 755673, an ...


Chronic Losartan Administration Reduces Mortality And Preserves Cardiac But Not Skeletal Muscle Function In Dystrophic Mice, Lawrence T. Bish, Mark Yarchoan, Margaret M. Sleeper, Jeffrey Gazzara, Kevin J. Morine, Pedro Acosta, Elisabeth R. Barton, H. Lee Sweeney 2011 University of Pennsylvania

Chronic Losartan Administration Reduces Mortality And Preserves Cardiac But Not Skeletal Muscle Function In Dystrophic Mice, Lawrence T. Bish, Mark Yarchoan, Margaret M. Sleeper, Jeffrey Gazzara, Kevin J. Morine, Pedro Acosta, Elisabeth R. Barton, H. Lee Sweeney

Departmental Papers (Vet)

Duchenne muscular dystrophy (DMD) is a degenerative disorder affecting skeletal and cardiac muscle for which there is no effective therapy. Angiotension receptor blockade (ARB) has excellent therapeutic potential in DMD based on recent data demonstrating attenuation of skeletal muscle disease progression during 6–9 months of therapy in the mdx mouse model of DMD. Since cardiac-related death is major cause of mortality in DMD, it is important to evaluate the effect of any novel treatment on the heart. Therefore, we evaluated the long-term impact of ARB on both the skeletal muscle and cardiac phenotype of the mdx mouse. Mdx mice ...


[Venous Thromboembolism Prophylaxis In Colombian Surgical And Medical Patients: Results For Colombia Of The Endorse Study], Rodolfo J. Dennis, Jairo H. Roa, Juan Villadiego, Freddy Mendez, Elias Vieda, Hector Restrepo 2011 Fundacion Cardioinfantil-Instituto de Cardiologia

[Venous Thromboembolism Prophylaxis In Colombian Surgical And Medical Patients: Results For Colombia Of The Endorse Study], Rodolfo J. Dennis, Jairo H. Roa, Juan Villadiego, Freddy Mendez, Elias Vieda, Hector Restrepo

ENDORSE Publications

INTRODUCTION: More information is needed on the risk of venous thromboembolism in the hospital setting, and on patterns of use of thromboprophylaxis, as advocated in consensus guidelines.ENDORSE was an international study aimed at evaluating hospital venous thromboembolism prevention practices in medical and surgical patients.

OBJECTIVES: The risk of venous thromboembolism was evaluated along with the use of thromboprophylaxis in hospitalized medical and surgical subjects; these data were compared with the international sample from the ENDORSE study.

MATERIALS AND METHODS: Participating institutions in Colombia were selected arbitrarily. The medical charts for medical and surgical patients were evaluated randomly. The 2004 ...


Chd Knowledge And Risk Factors Among Filipino-Americans Connected To Primary Care Services, Alona Dalusung-Angosta 2011 University of Nevada, Las Vegas

Chd Knowledge And Risk Factors Among Filipino-Americans Connected To Primary Care Services, Alona Dalusung-Angosta

Nursing Faculty Presentations

Problem:

Despite growing numbers of FAs in the U.S. and high CHD prevalence, only limited studies are available in the the literature.

Contributing factors?

  • Lack of knowledge
  • Sociodemographic (SD)/Socioeconomic (SE) variables


Ischemia Impairs Vasodilation In Skeletal Muscle Resistance Artery, Kyle Remington Struthers 2011 California Polytechnic State University, San Luis Obispo

Ischemia Impairs Vasodilation In Skeletal Muscle Resistance Artery, Kyle Remington Struthers

Master's Theses

Functional vasodilation in arterioles is impaired with chronic ischemia. We sought to examine the impact of chronic ischemia and age on skeletal muscle resistance artery function. To examine the impact of chronic ischemia, the femoral artery was resected from young (2-3mo) and adult (6-7mo) mice and the profunda femoris artery diameter was measured at rest and following gracilis muscle contraction 14 days later using intravital microscopy. Functional vasodilation was significantly impaired in ischemic mice (14.4±4.6% vs. 137.8±14.3%, p<0.0001 n=8) and non-ischemic adult mice (103.0±9.4% vs. 137.8±14.3%, p=0.05 n=10). In order to analyze the cellular mechanisms of the impairment, a protocol was developed to apply pharmacological agents to the experimental preparation while maintaining tissue homeostasis. Endothelial and smooth muscle dependent vasodilation were impaired with ischemia, 39.6 ± 13.6% vs. 80.5 ± 11.4% and 43.0 ± 11.7% vs. 85.1 ± 10.5%, respectively. From this data, it can be supported that smooth muscle dysfunction is the reason for the observed impairment in arterial vasodilation.


Effects Of A Multicomponent Wellness Intervention On Dyslipidemia In An Overweight Adolescent Population, Olga T. Hardy, Jean Wiecha, Albert Kim, Carlos Salas, Rayna Bricenoc, Kwesi Moody, Joan Becker, Greer Glazer, Carol A. Ciccarelli, Ling Shi, Laura L. Hayman 2011 University of Massachusetts Medical School

Effects Of A Multicomponent Wellness Intervention On Dyslipidemia In An Overweight Adolescent Population, Olga T. Hardy, Jean Wiecha, Albert Kim, Carlos Salas, Rayna Bricenoc, Kwesi Moody, Joan Becker, Greer Glazer, Carol A. Ciccarelli, Ling Shi, Laura L. Hayman

UMass Center for Clinical and Translational Science Research Retreat

Epidemiologic studies suggest that atherosclerotic processes begin in childhood and are associated with abnormal lipid levels. Behavioral changes are the first line of treatment for dyslipidemia in adolescents but outcome data on the effectiveness of this approach are inconsistent. This study aimed to assess the effect of a 13-week multicomponent wellness intervention program on dyslipidemia in lean and overweight/obese adolescents enrolled at a public high school in Boston, Massachusetts. The intervention was conducted at a university-based youth fitness center where 9 overweight/obese adolescents (body mass index [BMI]≥85th percentile for age and sex) and 9 lean adolescents (BMIsex ...


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