Relationships Among Stress Measures, Risk Factors, And Inflammatory Biomarkers In Law Enforcement Officers, Sandra L. Ramey, Nancy R. Downing, Warren D. Franke, Mohammad H. Alasagheirin
Law enforcement officers suffer higher morbidity and mortality rates from all causes than the general population. Cardiovascular disease (CVD) accounts for a significant portion of the excess illness, with a reported prevalence as high as 1.7 times that of the general population. To determine which occupational hazards cause this increased risk and morbidity, it is imperative to study law enforcement officers before they retire. The long-range goal of our research is to reduce the incidence of CVD-related illness and death among aging law enforcement officers. The purpose of the present study was to measure pro- and anti-atherogenic inflammatory markers ...
Artificial Devices As A Viable Alternative To The Conventional Heart Transplant, 2012 Touro College
Artificial Devices As A Viable Alternative To The Conventional Heart Transplant, Hadassah Radzik
The Science Journal of the Lander College of Arts and Sciences
The human heart is one of the most vital organs in the body. It distributes blood throughout the body, providing the body with oxygen and nutrition, and contributes to metabolism. When the heart fails, blood flow is impaired, thereby limiting the exchange of oxygen within the cardiopulmonary system as well as diminishing oxygenation and nutrition to the other major organs and periphery. The only current proven treatment for advanced heart failure is cardiac transplant. Given the heart’s importance and the scarcity of donated organs, modern medicine has experimented with the creation of an artificial heart. Because the heart is ...
Improved Left Ventricular Mass Quantification With Partial Voxel Interpolation – In-Vivo And Necropsy Validation Of A Novel Cardiac Mri Segmentation Algorithm, Noel C.F. Codella, Hae Yeoun Lee, David S. Fieno, Debbie W. Chen, Sandra M. Hurtado Rua, Minisha Kochar, John Paul Finn, Robert Judd, Parag Goyal, Jesse Schenendorf, Matthew D. Cham, Richard B. Devereux, Martin Prince, Yi Wang, Jonathan W. Weinsaft
Mathematics Faculty Publications
Background—CMR typically quantifies LV mass (LVM) via manual planimetry (MP), but this approach is time consuming and does not account for partial voxel components - myocardium admixed with blood in a single voxel. Automated segmentation (AS) can account for partial voxels, but this has not been used for LVM quantification. This study used automated CMR segmentation to test the influence of partial voxels on quantification of LVM. Methods and Results—LVM was quantified by AS and MP in 126 consecutive patients and 10 laboratory animals undergoing CMR. AS yielded both partial voxel (ASPV) and full voxel (ASFV) measurements ...
Physical Activity, Sleep Patterns, And Health Outcomes In University Law Enforcement Officers, 2012 University of Kentucky
Physical Activity, Sleep Patterns, And Health Outcomes In University Law Enforcement Officers, Nicole C. Koebke
Theses and Dissertations--Kinesiology and Health Promotion
Research indicates that law enforcement officers (LEOs) have a higher prevalence of developing coronary artery disease (CAD) compared to the general population. Sleep deprivation and physical inactivity have been found to be related to many risk factors for CAD. This cross-sectional study examined the health status and the relationship between sleep and physical activity outcomes versus CAD risk factors among 27 University LEOs. The subjects’ health behaviors, and CAD and metabolic syndrome risk factors were described using basic statistics. Accelerometer derived sleep and physical activity outcomes were correlated to measures of health to identify potential relationships. 33% of LEOs were ...
Designing New Drugs To Treat Cardiac Arrhythmia, 2012 Portland State University
Designing New Drugs To Treat Cardiac Arrhythmia, Yanping Ye
Dissertations and Theses
Heart failure resulting from different forms of cardiomyopathy is defined as the inability of the heart to pump sufficient blood to meet the body's metabolic demands. It is a major disease burden worldwide and the statistics show that 50% of the people who have the heart failure will eventually die from sudden cardiac death (SCD) associated with an arrhythmia. The central cause of disability and SCD is because of ventricular arrhythmias. Genetic mutations and acquired modifications to RyR2, the calcium release channel from sarcoplasmic reticulum, can increase the pathologic SR Ca2+ leak during diastole, which leads to defects in ...
What Evidence Is Available On Apixaban For The Primary Prevention Of Stroke In Patients With Atrial Fibrillation?, Justin Dang, Laura Tsu
Pharmacy Faculty Articles and Research
This drug information question and answer sheet discusses the use of apixaban (Eliquis) for the primary prevention of stroke in patients with atrial fibrillation.
Bilateral Medial Medullary Infarction: A Systematic Review, 2011 St Michael's Hospital, University of Toronto
Bilateral Medial Medullary Infarction: A Systematic Review, Gustavo Saposnik
No abstract provided.
Unmasking The Benefits Of B Vitamins In Stroke Prevention, 2011 St Michael's Hospital, University of Toronto
Unmasking The Benefits Of B Vitamins In Stroke Prevention, Gustavo Saposnik
No abstract provided.
High Fat Diet Enhances Cardiac Abnormalities In Shr Rats: Protective Role Of Heme Oxygenaseadiponectin Axis, Jian Cao, Komal Sodhi, Nitin Puri, Sumit R. Monu, Rita Rezzani, Nader G. Abraham
Pharmaceutical Science and Research
High dietary fat intake is a major risk factor for development of cardiovascular and metabolic dysfunction including obesity, cardiomyopathy and hypertension.
The present study was designed to examine effect of high fat (HF) diet on cardio-vascular structure and function in spontaneously hypertensive rats (SHR), fed HF diet for 15 weeks, a phenotype designed to mimic metabolic syndrome.
Development of metabolic syndrome like phenotype was confirmed using parameters, including body weight, total cholesterol and blood pressure levels. High fat diet impaired vascular relaxation by acetylcholine and exacerbated cardiac dysfunction in SHRs as evidenced by lower left ventricular function ...
Introduction Of The Tools For Economic Analysis Of Patient Management Interventions In Heart Failure Costing Tool: A User-Friendly Spreadsheet Program To Estimate Costs Of Providing Patient-Centered Interventions, 2011 University of Pennsylvania
Introduction Of The Tools For Economic Analysis Of Patient Management Interventions In Heart Failure Costing Tool: A User-Friendly Spreadsheet Program To Estimate Costs Of Providing Patient-Centered Interventions, Shelby D. Reed, Yanhong Li, Shital Kamble, Daniel Polsky, Felicia L. Graham, Margaret T. Bowers, Gregory P. Samsa, Sara Paul, Kevin A. Schulman, David J. Whellan, Barbara Riegel
School of Nursing Departmental Papers
Background—Patient-centered health care interventions, such as heart failure disease management programs, are under increasing pressure to demonstrate good value. Variability in costing methods and assumptions in economic evaluations of such interventions limit the comparability of cost estimates across studies. Valid cost estimation is critical to conducting economic evaluations and for program budgeting and reimbursement negotiations.
Methods and Results—Using sound economic principles, we developed the Tools for Economic Analysis of Patient Management Interventions in Heart Failure (TEAM-HF) Costing Tool, a spreadsheet program that can be used by researchers and health care managers to systematically generate cost estimates for economic ...
Characterization Of The Mechanism Of Pparγ-Mediated Neointima Formation In Rodents, 2011 University of Tennessee Health Science Center
Characterization Of The Mechanism Of Pparγ-Mediated Neointima Formation In Rodents, Ryoko Tsukahara
Theses and Dissertations (ETD)
Lysophosphatidic acid (LPA) and its ether analog alkyl glycerophosphate (AGP) elicit arterial wall remodeling when applied intralumenally into the uninjured carotid artery. LPA is the ligand of eight GPCRs and the peroxisome proliferator-activated receptor γ (PPARγ). We pursued a gene knockout strategy to identify the LPA receptor subtypes necessary for the neointimal response in a non-injury model of carotid remodeling and also compared the effects of AGP and the PPARγ agonist rosiglitazone (ROSI) on balloon injury-elicited neointima development. In the balloon injury model AGP significantly increased neointima; however, rosiglitazone application attenuated it. AGP and ROSI were also applied intralumenally for ...
Geographic Disparities Associated With Stroke And Myocardial Infarction In East Tennessee, 2011 University of Tennessee, Knoxville
Geographic Disparities Associated With Stroke And Myocardial Infarction In East Tennessee, Ashley Pedigo Golden
Stroke and myocardial infarction (MI) are serious conditions whose burdens vary by socio-demographic and geographic factors. Although several studies have investigated and identified disparities in burdens of these conditions at the county and state levels, little is known regarding their geographic epidemiology at the neighborhood level. Both conditions require emergency treatments and therefore timely geographic accessibility to appropriate care is critical. Investigation of disparities in geographic accessibility to stroke and MI care and the role of Emergency Medical Services (EMS) in reducing treatment delays are vital in improving health outcomes. Therefore, the objectives of this work were to: (i) classify ...
Can Antioxidant-Rich Berries Improve Risk Factors Associated With Cardiovascular Disease In Postmenopausal Smokers?, 2011 University of Arkansas, Fayetteville
Can Antioxidant-Rich Berries Improve Risk Factors Associated With Cardiovascular Disease In Postmenopausal Smokers?, Jordan Alaine Teeple
Graduate Theses and Dissertations
The purpose of this study was to examine the effects of smoking on risk factors associated with cardiovascular disease (CVD) and determine the efficacy of antioxidant-rich berries in ameliorating these risk factors in postmenopausal smokers. Menopause and cigarette smoking have been identified as major risk factors for CVD due to a decrease in antioxidant protection, increase in inflammation and oxidative stress, and adverse changes in serum lipids. Antioxidants, specifically flavonoid compounds found in blackberries and blueberries, have been shown to prevent low-density lipoprotein cholesterol oxidation and thus prevent downstream inflammation and oxidative stress. Healthy, postmenopausal nonsmokers (n=14) and smokers ...
Recent Trends In The Characteristics And Prognosis Of Patients Hospitalized With Acute Heart Failure, 2011 University of Massachusetts Medical School
Recent Trends In The Characteristics And Prognosis Of Patients Hospitalized With Acute Heart Failure, David Park, David D. Mcmanus, Chad E. Darling, Jordan H. Goldberg, Joel M. Gore, Darleen M. Lessard, Robert J. Goldberg
Population and Quantitative Health Sciences Publications
BACKGROUND: Despite the magnitude and impact of heart failure (HF) in the United States, relatively little data are available that describe the prognosis associated with acute HF, especially from the perspective of a population-based investigation. The purpose of this nonconcurrent prospective study was to describe the overall, and changing trends therein, prognosis of 4228 patients discharged from all eleven greater Worcester (MA) medical centers after a documented episode of acute HF and factors associated with an increased risk of dying after hospital discharge.
METHODS: The study population consisted of residents of the Worcester metropolitan area discharged after being hospitalized for ...
Adherence To The European Society Of Cardiology (Esc) Guidelines For Chronic Heart Failure - A National Survey Of The Cardiologists In Pakistan, 2011 Emory University School of Medicine, Atlanta GA, USA.
Adherence To The European Society Of Cardiology (Esc) Guidelines For Chronic Heart Failure - A National Survey Of The Cardiologists In Pakistan, Sana Shoukat, Saqib A. Gowani, Ather M. Taqui, Rameez Ul Hassan, Zain A. Bhutta, Anum I. Malik, Sajjad A. Sherjeel, Quratulanne Sheheryar, Sajid H. Dhakam
Section of Neurosurgery
Background:The aims of this study were to evaluate the awareness of and attitudes towards the 2005 European Society of Cardiology (ESC) guidelines for Heart Failure (HF) of the cardiologists in Pakistan and assess barriers to adherence to guidelines.
Methods: A cross-sectional survey was conducted in person from March to July 2009 to all cardiologists practicing in 4 major cities in Pakistan (Karachi, Lahore, Quetta and Peshawar). A validated, semi-structured questionnaire assessing ESC 2005 Guidelines for HF was used to obtain information from cardiologists. It included questions about awareness and relevance of HF guidelines (See Additional File 1). Respondents' management ...
Characteristics, Practice Patterns, And Outcomes In Patients With Acute Hypertension: European Registry For Studying The Treatment Of Acute Hypertension (Euro-Stat), 2011 Papworth Hospital NHS Foundation Trust
Characteristics, Practice Patterns, And Outcomes In Patients With Acute Hypertension: European Registry For Studying The Treatment Of Acute Hypertension (Euro-Stat), Alain Vuylsteke, Jean-Louis Vincent, Didier Payen De La Garanderie, Frederick A. Anderson Jr., Leigh A. Emery, Allison Wyman, Sophie Rushton-Smith, Joel M. Gore
Open Access Publications by UMMS Authors
INTRODUCTION: Although effective strategies are available for the management of chronic hypertension, less is known about treating patients with acute, severe elevations in blood pressure. Using data from the European registry for Studying the Treatment of Acute hyperTension (Euro-STAT), we sought to evaluate 'real-life' management practices and outcomes in patients who received intravenous antihypertensive therapy to treat an episode of acute hypertension.
METHODS: Euro-STAT is a European, hospital-based, observational study of consecutive adult patients treated with intravenous antihypertensive therapy while in the emergency department, perioperative unit or ICU. Enrolment took place between 1 July and 15 October 2009 in 11 ...
Percutaneous Implantation Of The Edwards Sapien Transcatheter Heart Valve For Conduit Failure In The Pulmonary Position: Early Phase 1 Results From An International Multicenter Clinical Trial., 2011 Children's Mercy Hospital
Percutaneous Implantation Of The Edwards Sapien Transcatheter Heart Valve For Conduit Failure In The Pulmonary Position: Early Phase 1 Results From An International Multicenter Clinical Trial., Damien Kenny, Ziyad M. Hijazi, Saibal Kar, John Rhodes, Michael Mullen, Raj Makkar, Girish S. Shirali, Mark Fogel, John Fahey, Mary G. Heitschmidt, Christopher Cain
Manuscripts, Articles, Book Chapters and Other Papers
OBJECTIVES: The purpose of this study was to evaluate the safety and effectiveness of the Edwards SAPIEN transcatheter heart valve (Edwards Lifesciences LLC, Irvine, California) in the pulmonary position in patients with moderate to severe pulmonary regurgitation with or without stenosis.
BACKGROUND: Transcatheter pulmonary valve replacement is evolving, but to date, experience has been limited to the Melody valve (Medtronic Inc., Minneapolis, Minnesota).
METHODS: Eligible patients with dysfunctional right ventricle-to-pulmonary artery conduits were screened if body weight was ≥35 kg and the in situ conduit diameter was ≥16 mm and ≤24 mm. Standardized implantation and follow-up protocols were used.
Elsa-Brasil: Historico [In Portuguese], 2011 Universidade de São Paulo
Elsa-Brasil: Historico [In Portuguese], Paulo A. Lotufo
Paulo A Lotufo
No abstract provided.
Behavioral Health Change In Appalachian Women With High Cardiovascular Disease Risk Report, 2011 University of Kentucky
Behavioral Health Change In Appalachian Women With High Cardiovascular Disease Risk Report, Sarah Cole
No abstract provided.
Vigilância Em Doença Cerebrovascular [Portuguese], 2011 Universidade de São Paulo
Vigilância Em Doença Cerebrovascular [Portuguese], Paulo A. Lotufo
Paulo A Lotufo
No abstract provided.