Systems Biology Commons^™

Vascular Plants Of The Forest River Bi- Ology Station, North Dakota, Alexey Shipunov, Kathryn A. Yurkonis, John C. La Duke, Vera L. Facey

The Prairie Naturalist

During summer 2013 we completed a listing of the plant species of the joint University of North Dakota (UND) Forest River Biology Station and North Dakota Game and Fish Department Wildlife Management Area (FRBS).The FRBS is a 65 ha tract of land that encompasses the south half of the SW 1⁄4 of section 11 (acquired by UND in 1952) and the north half of the NW 1⁄4 of section 14 (acquired by UND in 1954) in Inkster Township (T154N, R55W). The two parcels are bisected by the Forest River, a tributary of the Red River of the North. The area …

Food Habits Of Fall-Collected Age-0 Walleyes In Eastern South Dakota Gla- Cial Lakes, Benjamin J. Schall, Matthew J. Phayvanh, Jeffrey D. Grote, Daniel J. Dembkowski, Melissa R. Wuellner

The Prairie Naturalist

Food habits of age-0 fishes can influence their growth and survival prior to the first winter (Hoxmeier et al. 2006, Shoup and Wahl 2011). Ontogenetic diet shifts in juvenile piscivorous fishes result in a transition in consumption from zooplankton to macroinvertebrates and eventually fish throughout development (Mittelbach and Persson 1998). Certain food items may be more energetically beneficial to fishes than others as consumption of prey fishes may lead to faster growth rates of predators, decreased overwinter starvation, avoidance of competition, and reduced predation risk (Werner and Gilliam 1984). By the time age-0 walleyes (Sander vitreus) have reached lengths of …

Bot Fly Infestation Of Thirteen-Lined Ground Squirrels In Colorado Shortgrass Steppe, Kim Conway, Paul Stapp

The Prairie Naturalist

We studied prevalence of bot fly infestation of thirteen-lined ground squirrels (Ictidomys tridecemlineatus) trapped during 13 years of population monitoring in shrub and grassland habitats in northern Colorado. We also investigated effects of prescribed burning, a common habitat management practice in grasslands, on bot fly prevalence. Infested squirrels were rarely located on shrub sites and during spring (May–Jun) trapping. Across all summers, mean prevalence in grasslands was 7.9% (range: 2.1–23.8%), with years of highest prevalence corresponding to years when the fewest hosts were captured in spring. Infested squirrels had from one to seven warbles, with 46.7% having only one warble. …

A Model Of How Different Biology Experts Explain Molecular And Cellular Mechanisms, Caleb M. Trujillo, Trevor R. Anderson, Nancy J. Pelaez

PIBERG Publications

Constructing explanations is an essential skill for all science learners. The goal of this project was to model the key components of expert explanation of molecular and cellular mechanisms. As such, we asked: What is an appropriate model of the components of explanation used by biology experts to explain molecular and cellular mechanisms? Do explanations made by experts from different biology subdisciplines at a university support the validity of this model? Guided by the modeling framework of R. S. Justi and J. K. Gilbert, the validity of an initial model was tested by asking seven biologists to explain a molecular …

Improving Communication Through Writing, Christopher N. Jacques

The Prairie Naturalist

Greetings GPNSS members! By the time you read this editorial, most of us will be enjoying the summer vacation and all that the Great Plains has to offer. Warmer temperatures, increasing day length, and time in the field are a welcomed change from the seemingly endless grip of “old man” winter (for those of us in the northern Great Plains). Of course, believing that anyone could truly enjoy the clouds of tormenting, biting insects and high humidity across the Great Plains is hard to imagine, in my opinion. There are plenty of summer activities for the outdoor enthusiasts among us, …

West Nile Virus And Ferruginous Hawks (Buteo Regalis) In The Northern Great Plains, Shubham Datta, Jonathan A. Jenks, David E. Knudsen, Kent C. Jensen, Will M. Inselman, Christopher C. Swanson, Troy W. Grovenburg

The Prairie Naturalist

Emerging infectious diseases (EID) present significant threats to the conservation of global biodiversity (Daszak et al. 2000). Evaluating impacts (spatial, temporal and demographic) of EIDs on sensitive and declining wildlife populations is challenging because quantitative information is usually dependent on estimates rather than counts (Wobeser 2007) and mortality rates are seldom quantified with conventional monitoring (Naugle et al. 2005).

West Nile virus (WNv), a mosquito-borne Flavivirus (family Flaviviridae; Komar 2001), was discovered in northwest Uganda in 1937 (Smithburn et al. 1940). First encountered in the western hemisphere in New York in 1999 (Nash et al. 2001), WNv has become enzootic …

Habitat-Related Differences In Necroph- Ilous Species Composition: Implications For Resource Competition, Adrienne L. Conley, Elisabeth K. Jorde, Rachel E. Jorde, Lauren K. Yares, Kenzie K. Lee, Carrie L. Hall, Daniel R. Howard

The Prairie Naturalist

Competition for resources is one of the most important selective factors influencing the expression of life history traits in both plants and animals (Darwin 1859). In grasslands, competition for resources such as nutrients, water, and space often is constrained by stochastic processes (Axelrod 1985). Disturbance factors such as fire, grazing by large herbivores, and fluctuating climatic conditions tend to alter the structure and magnitude of competition for limited resources among grassland communities more frequently than in other ecosystems (Snaydon 1987, van der Maarel 1993). Vertebrate carrion is one important resource used by both plants and animals in grasslands, providing a …

Comparison Of Two Trap Net Designs For Sampling Muskellunge, Brian G. Blackwell, Todd M. Kaufman, Tyrel S. Moos, David O. Lucchesi

The Prairie Naturalist

Sampling adequate numbers of muskellunge (Esox masquinongy) is necessary to evaluate stocking success and to collect information on various population metrics (e.g., growth, condition, relative abundance). However, muskellunge are often difficult to sample with standard fish sampling gears. We collected muskellunge in trap nets of two different designs (large trap nets [1.5-m × 1.8-m frames, 1.5-m diameter hoops, double throated, single 1.5-m × 30.5-m lead and 19-mm knotless mesh] and small trap nets [0.9-m × 1.5-m frames, 0.9-m diameter hoops, single throat, single 0.9-m × 15.2-m lead and 19-mm knotted mesh]. We also estimated abundance of muskellunge (>600 mm …

Using Otolith Microchemistry To Classify Yellow Perch As Stocked Or Naturally Produced, Andrew K. Carlson, Matthew J. Ward, Brian D.S Graeb

The Prairie Naturalist

Fisheries managers routinely use stocking to supplement fish populations (Schramm and Piper 1995, Fisher 1996). Stocking eyed-eggs offers substantial cost savings compared to stocking fry and fingerlings (PFBC 2011); however, traditional stocking evaluation using oxytetracycline (OTC) marking of otoliths is ineffective for eyed-eggs of some species (e.g., yellow perch, [Perca fla- vescens]). Thus, there is a need for additional approaches to be able to classify fish as stocked or naturally produced. Fish otoliths are paired calcified structures in the inner ear that permanently deposit trace elements in proportion to water column concentrations (Campana 1999, Campana et al. 2000). Coupled with …

Phylogenetic Relationships Of Samydaceae And Taxonomic Revision Of The Species Of Casearia In South-Central Asia, Tharangamala Samarakoon

Dissertations

The flowering plant family Samydaceae was recently reinstated to include 14 genera and about 256 species of tropical trees and shrubs. Preliminary analyses of relationships in the family, however, indicated that the largest genus in the family, Casearia, is not monophyletic and that several smaller groups are probably misplaced. In order to affirm or refute those hypotheses, additional DNA sequence data with broader taxon sampling from the Old World were gathered for phylogenetic analysis. In particular, rapidly evolving plastid (matK, ndhF, psbA-trnH, trnL, and trnL-F) and nuclear (EMB2765 and GBSSI) DNA …

Pathological Effects Of Repeated Concussive Tbi In Mouse Models: Periventricular Damage And Ventriculomegaly, Richard H. Wolferz Jr.

Honors Scholar Theses

Repeated concussive traumatic brain injury (rcTBI) is the most prominent form of head injury affecting the brain, with an estimated 1.7 million Americans affected each year (Kuhn 2012). Neurologists have been concerned about the danger of repeated head impacts since the 1920’s, but researchers have only begun to understand the long-term effects of rcTBI (McKee 2009). Although symptoms can be as mild as dizziness, current research suggests that multiple concussions can lead to a progressive degenerative brain disease known as chronic traumatic encephalopathy (CTE) (Luo 2008, McKee 2009, Kane 2013). Research on the brain is just beginning to scratch the …

The Heritability Of Shell Morphometrics In The Freshwater Pulmonate Gastropod Physa, Robert T. Dillon Jr., Stephen J. Jacquemin

Biological Sciences Faculty Publications

The cosmopolitan freshwater pulmonate snail Physa acuta hybridizes readily with Physa carolinae in the laboratory, although their F1 progeny are sterile. The two species differ qualitatively in shell shape, the former bearing a more globose shell and the latter more fusiform. We performed a hybridization experiment, measuring a set of 14 traditional (linear) and landmark-based shell morphological variables on even-aged parents and their offspring from both hybrids and purebred control lines. Parent-offspring regression yielded a strikingly high heritability estimate for score on the first relative warp axis, h² = 0.819 ± 0.073, a result that would seem to confirm …

Targeted Single Molecule Sequencing Methodology For Ovarian Hyperstimulation Syndrome., Funda Orkunoglu-Suer, Arthur F. Harralson, David Frankfurter, Paul Gindoff, Travis J. O'Brien

Genomics and Precision Medicine Faculty Publications

BACKGROUND: One of the most significant issues surrounding next generation sequencing is the cost and the difficulty assembling short read lengths. Targeted capture enrichment of longer fragments using single molecule sequencing (SMS) is expected to improve both sequence assembly and base-call accuracy but, at present, there are very few examples of successful application of these technologic advances in translational research and clinical testing. We developed a targeted single molecule sequencing (T-SMS) panel for genes implicated in ovarian response to controlled ovarian hyperstimulation (COH) for infertility.

RESULTS: Target enrichment was carried out using droplet-base multiplex polymerase chain reaction (PCR) technology (RainDance®) …

The Treat-Nmd Advisory Committee For Therapeutics (Tact): An Innovative De-Risking Model To Foster Orphan Drug Development., Emma Heslop, Cristina Csimma, Volker Straub, John Mccall, Kanneboyina Nagaraju, Kathryn R. Wagner, Didier Caizergues, Rudolf Korinthenberg, Kevin M. Flanigan, Petra Kaufmann, Elizabeth Mcneil, Jerry Mendell, Sharon Hesterlee, Dominic J. Wells, Kate Bushby

Genomics and Precision Medicine Faculty Publications

Despite multiple publications on potential therapies for neuromuscular diseases (NMD) in cell and animal models only a handful reach clinical trials. The ability to prioritise drug development according to objective criteria is particularly critical in rare diseases with large unmet needs and a limited numbers of patients who can be enrolled into clinical trials. TREAT-NMD Advisory Committee for Therapeutics (TACT) was established to provide independent and objective guidance on the preclinical and development pathway of potential therapies (whether novel or repurposed) for NMD.We present our experience in the establishment and operation of the TACT. TACT provides a unique resource of …

Fauna Census Of Intertidal Cliffs, Mangapwani, Zanzibar, Emily Jankowski

Independent Study Project (ISP) Collection

Due to their extreme variations in condition over the course of a day, intertidal zones are challenging environments. Organisms that live there must be prepared to cope with both exposure and submersion, not to mention the temperature variations that accompany these conditions. The differing tolerances and adaptations of various organisms to these conditions generally cause patterns of vertical zonation to occur in the intertidal zone, especially when the shore is steep and rocky. Understanding the ecology of shore environments is important to future conservation and management efforts. This study was conducted on a beach in Mangapwani, Zanzibar at at 6˚ …

Genetic Modifiers Of Ambulation In The Cinrg Duchenne Natural History Study., Luca Bello, Akanchha Kesari, Heather A. Gordish-Dressman, Avital Cnaan, Lauren P Morgenroth, Jaya Punetha, Tina Duong, Erik Henricson, Elena Pegoraro, Craig M. Mcdonald, Eric P. Hoffman

Genomics and Precision Medicine Faculty Publications

No abstract provided.

Fish Use Of Largely Unexplored Sub-Tidal Habitats In The Hinchinbrook Channel Estuary, Queensland, Alexandra Parisien

Independent Study Project (ISP) Collection

This study examines the use of sub-tidal open-bottom, rocky, and seagreass habitats by the Siganus genus (herbivores), Gerres genus (benthivores), and planktivores in the Hinchinbrook Channel Estuary in Queensland, Australia. The Hinchinbrook Channel Estuary, a tropical estuary cutting between Hinchinbrook Island and the Australian mainland, is surrounded primarily by mangroves. Its sub-tidal habitats are largely unexplored due to factors such as low visibility and the presence of estuarine crocodiles. In this study, I reviewed 699 underwater videos collected by James Cook University PhD candidate Michael Bradley in order to analyze feeding and movement behavior of pre-identified fish.

The results of …

Tyrosine 705 Phosphorylation Of Stat3 Is Associated With Phenotype Severity In Tgfβ1 Transgenic Mice, Eleonora Guadagnin, Jigna Narola, Carsten G. Bonnemann, Yi-Wen Chen

Genomics and Precision Medicine Faculty Publications

Transforming growth factor beta 1 (TGFβ1) is a key player in skeletal muscle degenerative and regenerative processes. We previously showed that conditionally overexpressing TGFβ1 in skeletal muscles caused myofiber atrophy and endomysial fibrosis in mice. However, the disease severity varied significantly among individual mice. While 40% of mice developed severe muscle pathology and lost body weight within 2 weeks of TGFβ1 transgene induction in muscles, the rest showed milder or no phenotype. This study aims at determining whether signal transducer and activator of transcription 3 (STAT3) plays a role in the phenotypic difference and whether it can be activated by …

Adenovirus Entry From The Apical Surface Of Polarized Epithelia Is Facilitated By The Host Innate Immune Response, Poornima L.N. Kotha, Priyanka Sharma, Abimbola O. Kolawole, Ran Yan, Mahmoud Alghamri, Trisha L. Brockman, Julian Gomez-Cambronero, Julian Cambronero

Biological Sciences Faculty Publications

Prevention of viral-induced respiratory disease begins with an understanding of the factors that increase or decrease susceptibility to viral infection. The primary receptor for most adenoviruses is the coxsackievirus and adenovirus receptor (CAR), a cell-cell adhesion protein normally localized at the basolateral surface of polarized epithelia and involved in neutrophil transepithelial migration. Recently, an alternate isoform of CAR, CAREx8, has been identified at the apical surface of polarized airway epithelia and is implicated in viral infection from the apical surface. We hypothesized that the endogenous role of CAR^Ex8 may be to facilitate host innate immunity. We show that IL-8, …

The Mayfly Newsletter, Peter M. Grant

The Mayfly Newsletter

The Mayfly Newsletter is the official newsletter of the Permanent Committee of the International Conferences on Ephemeroptera.