Molecular Signatures Of Differential Responses To Exercise Trainings During Rehabilitation.,
2017
George Washington University
Molecular Signatures Of Differential Responses To Exercise Trainings During Rehabilitation., Yi-Wen Chen, Chris Gregory, Fan Ye, Naoe Harafuji, Donovan Lott, San-Huei Lai, Sunita Mathur, Mark Scarborough, Parker Gibbs, Celine Baligand, Krista Vandenborne
Genomics and Precision Medicine Faculty Publications
The loss and recovery of muscle mass and function following injury and during rehabilitation varies among individuals. While recent expression profiling studies have illustrated transcriptomic responses to muscle disuse and remodeling, how these changes contribute to the physiological responses are not clear. In this study, we quantified the effects of immobilization and subsequent rehabilitation training on muscle size and identified molecular pathways associated with muscle responsiveness in an orthopaedic patient cohort study. The injured leg of 16 individuals with ankle injury was immobilized for a minimum of 4 weeks, followed by a 6-week rehabilitation program. The maximal cross-sectional area (CSA) …
Evidence Of Morphological And Functional Variation Among Bluegill Lepomis Macrochirus Populations Across Grand Lake St Mary's Watershed Area,
2017
Wright State University - Main Campus
Evidence Of Morphological And Functional Variation Among Bluegill Lepomis Macrochirus Populations Across Grand Lake St Mary's Watershed Area, Anthony Bell, Stephen J. Jacquemin
Biological Sciences Faculty Publications
A myriad of factors have been shown to influence the morphology offreshwaterfish. However, studies that parse out where variation is comingfrom (e.g. body size, sex, and habitat) as well as what potential thesechanges have to influence function (e.g. swimming performance) areunderstudied. Therefore, the objectives of this study were to describemorphological variation of BluegillLepomis macrochirusacross the GrandLake St Mary’s watershed area (northwest OH, USA) and test forcovariation of morphology with size, sex, and habitat as well as to assessswimming performance to discern whether any differences in habitat (andmorphology) correspond with functional aspects related to criticalswimming velocity. Geometric morphometric methods were used …
Biosimp: Using Software Testing Techniques For Sampling And Inference In Biological Organisms,
2017
University of Nebraska-Lincoln
Biosimp: Using Software Testing Techniques For Sampling And Inference In Biological Organisms, Mikaela Cashman, Jennie L. Catlett, Myra B. Cohen, Nicole R. Buan, Zahmeeth Sakkaff, Massimiliano Pierobon, Christine A. Kelley
School of Computing: Conference and Workshop Papers
Years of research in software engineering have given us novel ways to reason about, test, and predict the behavior of complex software systems that contain hundreds of thousands of lines of code. Many of these techniques have been inspired by nature such as genetic algorithms, swarm intelligence, and ant colony optimization. In this paper we reverse the direction and present BioSIMP, a process that models and predicts the behavior of biological organisms to aid in the emerging field of systems biology. It utilizes techniques from testing and modeling of highly-configurable software systems. Using both experimental and simulation data we show …
First Definitive Fossil Of An Oestroid Fly (Diptera: Calyptratae: Oestroidea) And The Dating Of Oestroid Divergences,
2017
Wright State University - Main Campus
First Definitive Fossil Of An Oestroid Fly (Diptera: Calyptratae: Oestroidea) And The Dating Of Oestroid Divergences, Pierfilippo Cerretti, John O. Stireman Iii, Thomas Pape, James E. O'Hara, Marco A. Marinho, Knut Rognes, David A. Grimaldi
Biological Sciences Faculty Publications
Calyptrate flies include about 22,000 extant species currently classified into Hippoboscoidea (tsetse, louse, and bat flies), the muscoid grade (house flies and relatives) and the Oestroidea (blow flies, bot flies, flesh flies, and relatives). Calyptrates are abundant in nearly all terrestrial ecosystems, often playing key roles as decomposers, parasites, parasitoids, vectors of pathogens, and pollinators. For oestroids, the most diverse group within calyptrates, definitive fossils have been lacking. The first unambiguous fossil of Oestroidea is described based on a specimen discovered in amber from the Dominican Republic. The specimen was identified through digital dissection by CT scans, which provided morphological …
A New Tachinid Genus And Species Record For North America: Iceliopsis Borgmeieri Guimarães,
2017
Wright State University - Main Campus
A New Tachinid Genus And Species Record For North America: Iceliopsis Borgmeieri Guimarães, John O. Stireman Iii, Jane E. Dell
Biological Sciences Faculty Publications
The Iceliini are a small, enigmatic New World tribe of Tachininae consisting of three genera, Icelia RobineauDesvoidy, Iceliopsis Guimarães, and Erviopsis Townsend, and five recognized species (Guimarães 1976). All known species are exclusively Neotropical in distribution with the exception of Icelia triquetra (Olivier), which ranges from Brazil, through Central America, and as far north as New York state (O’Hara & Wood 2004). Members of the tribe are generally medium-sized (ca. 7–12 mm), elongate, yellowish or grayish in color, and resemble Dexiini or Leskiini in general appearance. Species of Iceliini are relatively rarely collected and there is but a single host …
Intercellular Adhesion Molecule-1 Augments Myoblast Adhesion And Fusion Through Homophilic Trans-Interactions,
2017
Wright State University - Main Campus
Intercellular Adhesion Molecule-1 Augments Myoblast Adhesion And Fusion Through Homophilic Trans-Interactions, Francis X. Pizza, Ryan A. Martin, Evan M. Springer, Maxwell S. Leffler, Bryce R. Woelmer, Issac J. Recker, Douglas W. Leaman
Biological Sciences Faculty Publications
The overall objective of the study was to identify mechanisms through which intercellular adhesion molecule-1 (ICAM-1) augments the adhesive and fusogenic properties of myogenic cells. Hypotheses were tested using cultured myoblasts and fibroblasts, which do not constitutively express ICAM-1, and myoblasts and fibroblasts forced to express full length ICAM-1 or a truncated form lacking the cytoplasmic domain of ICAM-1. ICAM-1 mediated myoblast adhesion and fusion were quantified using novel assays and cell mixing experiments. We report that ICAM-1 augments myoblast adhesion to myoblasts and myotubes through homophilic trans-interactions. Such adhesive interactions enhanced levels of active Rac in adherent and …
Synaptic Up-Scaling Preserves Motor Circuit Output After Chronic, Natural Inactivity,
2017
Wright State University - Main Campus
Synaptic Up-Scaling Preserves Motor Circuit Output After Chronic, Natural Inactivity, Joseph Michael Santin, Mauricio Vallejo, Lynn K. Hartzler
Biological Sciences Faculty Publications
Neural systems use homeostatic plasticity to maintain normal brain functions and to prevent abnormal activity. Surprisingly, homeostatic mechanisms that regulate circuit output have mainly been demonstrated during artificial and/or pathological perturbations. Natural, physiological scenarios that activate these stabilizing mechanisms in neural networks of mature animals remain elusive. To establish the extent to which a naturally inactive circuit engages mechanisms of homeostatic plasticity, we utilized the respiratory motor circuit in bullfrogs that normally remains inactive for several months during the winter. We found that inactive respiratory motoneurons exhibit a classic form of homeostatic plasticity, up-scaling of AMPA-glutamate receptors. Up-scaling increased the …
Insights Into The Ecology, Genetics And Distribution Of Lucanus Elaphus Fabricius (Coleoptera: Lucanidae), North America's Giant Stag Beetle,
2017
Wright State University - Main Campus
Insights Into The Ecology, Genetics And Distribution Of Lucanus Elaphus Fabricius (Coleoptera: Lucanidae), North America's Giant Stag Beetle, Michael D. Ulyshen, Louis G. Zachos, John O. Stireman Iii, Thomas N. Sheehan, Ryan C. Garrick
Biological Sciences Faculty Publications
1. Little is known about the biology or conservation status of Lucanus elaphus Fabricius in North America despite well-documented declines of a related species, Lucanus cervus (L.), in Europe. This study provides information critical to developing conservation plans for L. elaphus including the species’ larval substrate requirements, genetic data and range-wide estimates of habitat suitability. 2. In Mississippi floodplain forests, larval L. elaphus were recovered from a wide range of log sizes and rot types and were either found tunnelling within the wood or feeding beneath logs at the soil–wood interface. The species appears to require 1–2 years to complete …
Network Analytics For The Mirna Regulome And Mirna-Disease Interactions,
2017
Virginia Commonwealth University
Network Analytics For The Mirna Regulome And Mirna-Disease Interactions, Joseph Jayakar Nalluri
Theses and Dissertations
miRNAs are non-coding RNAs of approx. 22 nucleotides in length that inhibit gene expression at the post-transcriptional level. By virtue of this gene regulation mechanism, miRNAs play a critical role in several biological processes and patho-physiological conditions, including cancers. miRNA behavior is a result of a multi-level complex interaction network involving miRNA-mRNA, TF-miRNA-gene, and miRNA-chemical interactions; hence the precise patterns through which a miRNA regulates a certain disease(s) are still elusive. Herein, I have developed an integrative genomics methods/pipeline to (i) build a miRNA regulomics and data analytics repository, (ii) create/model these interactions into networks and use optimization techniques, motif …
Vamorolone, A Dissociative Steroidal Compound, Reduces Pro-Inflammatory Cytokine Expression In Glioma Cells And Increases Activity And Survival In A Murine Model Of Cortical Tumor.,
2016
George Washington University
Vamorolone, A Dissociative Steroidal Compound, Reduces Pro-Inflammatory Cytokine Expression In Glioma Cells And Increases Activity And Survival In A Murine Model Of Cortical Tumor., Elizabeth Wells, Madhuri Kambhampati, Jesse M Damsker, Heather Gordish-Dressman, Sridevi Yadavilli, Oren J Becher, Jamila Gittens, Mojca Stampar, Roger J. Packer, Javad Nazarian
Genomics and Precision Medicine Faculty Publications
Corticosteroids, such as dexamethasone, are routinely used as palliative care in neuro-oncology for their anti-inflammatory benefits, however many patients experience dose limiting side effects caused by glucocorticoid response element (GRE)-mediated transcription. The purpose of this study was to use a murine model to investigate a new steroid alternative, vamorolone, which promises to reduce side effects through dissociating GRE-mediated transcription and NF-κB -mediated anti-inflammatory actions. To compare vamorolone to dexamethasone in reducing pro-inflammatory signals in vitro, murine glioma cells were treated with dexamethasone, vamorolone or vehicle control. Changes in mRNA expression were assessed using the nanostring inflammatory platform. Furthermore, drug …
Global Gene Expression Profiling Of Healthy Human Brain And Its Application In Studying Neurological Disorders,
2016
University of Nebraska Medical Center
Global Gene Expression Profiling Of Healthy Human Brain And Its Application In Studying Neurological Disorders, Simarjeet K. Negi
Theses & Dissertations
The human brain is the most complex structure known to mankind and one of the greatest challenges in modern biology is to understand how it is built and organized. The power of the brain arises from its variety of cells and structures, and ultimately where and when different genes are switched on and off throughout the brain tissue. In other words, brain function depends on the precise regulation of gene expression in its sub-anatomical structures. But, our understanding of the complexity and dynamics of the transcriptome of the human brain is still incomplete. To fill in the need, we designed …
Effect Of Arginine On Oligomerization And Stability Of N-Acetylglutamate Synthase.,
2016
George Washington University
Effect Of Arginine On Oligomerization And Stability Of N-Acetylglutamate Synthase., N Haskins, A Mumo, P H Brown, Mendel Tuchman, Hiroki Morizono, L Caldovic
Genomics and Precision Medicine Faculty Publications
N-acetylglutamate synthase (NAGS; E.C.2.3.1.1) catalyzes the formation of N-acetylglutamate (NAG) from acetyl coenzyme A and glutamate. In microorganisms and plants, NAG is the first intermediate of the L-arginine biosynthesis; in animals, NAG is an allosteric activator of carbamylphosphate synthetase I and III. In some bacteria bifunctional N-acetylglutamate synthase-kinase (NAGS-K) catalyzes the first two steps of L-arginine biosynthesis. L-arginine inhibits NAGS in bacteria, fungi, and plants and activates NAGS in mammals. L-arginine increased thermal stability of the NAGS-K from Maricaulis maris (MmNAGS-K) while it destabilized the NAGS-K from Xanthomonas campestris (XcNAGS-K). Analytical gel chromatography and ultracentrifugation indicated tetrameric structure of the …
The Effect Of Wee1 On Mitosis In The Spb Mutant,
2016
Western Michigan University
The Effect Of Wee1 On Mitosis In The Spb Mutant, David Leroy
Honors Theses
The speedbump mutant has been identified as an early arrest mutant, becoming apparent as soon as 80% epiboly (8.5 hours of development). This mutant has a mutation in wee1, which is a protein regulating entry into mitosis ensuring the completion of DNA replication before mitosis. The lack of this protein in speedbump allows for early entry into mitosis resulting in damage to the chromosome. Here, we investigate two questions: if mitosis in the speedbump mutant phenotype is more frequent than wild-type phenotype, and, if so, is there a phase in which the mutant phenotype favors. We used phosphorylated histone H3 …
Review Of Booming From The Mists Of Nowhere: The Story Of The Greater Prairie-Chicken By Greg Hoch,
2016
Minnesota Department of Natural Resources, Crookston
Review Of Booming From The Mists Of Nowhere: The Story Of The Greater Prairie-Chicken By Greg Hoch, Ross H. Hier
The Prairie Naturalist
The Greater Prairie-Chicken (Tympanuchus cupido pinnatus) is an iconic species inhabiting one of the most iconic and rarest habitats in the world—the tallgrass prairies of central North America. To tell the story of the Greater Prairie-Chicken is a monumental task. Its history is intricately woven into pre- and post-European settlement of the North American prairies in such a way that knowledge of the species is spread over several centuries. Thus, researching the “old and the new” regarding the Greater Prairie-Chicken requires a substantial literature review, much of which occurs in publications from the 1800s. Hoch has done a …
Review Of Plants Have So Much To Give Us, All We Have To Do Is Ask: Anishinaabe Botanical Teachings By Mary Siisip Geniusz (Edited By Wendy Makoons Geniusz, Illustrated By Annmarie Geniusz),
2016
University of Kansas
Review Of Plants Have So Much To Give Us, All We Have To Do Is Ask: Anishinaabe Botanical Teachings By Mary Siisip Geniusz (Edited By Wendy Makoons Geniusz, Illustrated By Annmarie Geniusz), Natasha Myhal, Kelly Kindscher
The Prairie Naturalist
Plants Have So Much to Give Us, All We Have to Do Is Ask offers a new look at Anishinaabe (Ojibwe) ethnobotany as told through traditional stories. Botanical teachings through stories are a way to pass down traditional knowledge from generation to generation. For example, Anishinaabe knowledge on plants was written and recorded in communities willing to share their knowledge with early scholars, such as Albert B. Reagan (1928), Huron H. Smith (1932), and Melvin R. Gilmore (1933). Each of these scholars spent time with an Anishinaabe community to learn about plants and primarily to provide written descriptions of plants …
Review Of Estimation Of Parameters For Animal Populations: A Primer For The Rest Of Us By Larkin A. Powell And George A. Gale,
2016
United States Geological Survey, Northern Prairie Wildlife Research Center
Review Of Estimation Of Parameters For Animal Populations: A Primer For The Rest Of Us By Larkin A. Powell And George A. Gale, Max Post Van Der Burg
The Prairie Naturalist
“Me? A modeler? Never!” This is the opening challenge of the book, Estimation of Parameters for Animal Populations: A Primer for the Rest of Us, by Larkin Powell and George Gale. I say “challenge” because I think this book attempts to challenge the misconception that quantitative methods are out of reach for most biologists and wildlife scientists. When many of us attend college or graduate school to study wildlife science there’s a sense that, at some point, there will be math. But it appears that the attitude of many students toward this reality is to simply suffer through the …
Assessment Of Smallmouth Bass Growth And Mortality In Nebraska Waters,
2016
University of Nebraska at Kearney
Assessment Of Smallmouth Bass Growth And Mortality In Nebraska Waters, Benjamin J. Schall, Keith D. Koupal, Casey W. Schoenebeck, Keith L. Hurley
The Prairie Naturalist
Smallmouth bass (Micropterus dolomieu) have been introduced across Nebraska into a variety of waterbodies. However, an estimate of smallmouth bass growth and mortality in Nebraska waters has not been produced. The objectives of this study were to use historic sampling data to describe the growth of smallmouth bass in Nebraska lakes in relation to other regional models, growth among waterbody types (reservoirs, Interstate 80 [I-80] lakes, and rivers), estimates of age at quality, preferred, and memorable lengths, and mortality for Nebraska smallmouth bass populations. Mean length ± SE of Nebraska smallmouth bass at age 7 was 383 ± …
Finding The Best Remaining Black Hills Montane Grasslands, The First Step In Conservation,
2016
Laramie, Wyoming
Finding The Best Remaining Black Hills Montane Grasslands, The First Step In Conservation, Hollis Marriott, Don Faber-Langendoen, David J. Ode
The Prairie Naturalist
Black Hills Montane Grassland is a rare and endangered plant community endemic to the Black Hills of western South Dakota and northeastern Wyoming. It is restricted to higher elevations on the Limestone Plateau in the western part of the uplift. Early visitors to the Black Hills wrote glowing reports of flower-filled grasslands on the Limestone Plateau. Lieutenant Colonel George A. Custer and his soldiers reveled in lush grass, and decorated the headgear of their horses with flowers (Custer 1875). Expedition botanist A. B. Donaldson “estimated the number of flowers in bloom in Floral Valley at 50, while an equal number …
Changes In The Prairie Naturalist For 2017: Some Bumps In The Road During Transition,
2016
Western Illinois University
Changes In The Prairie Naturalist For 2017: Some Bumps In The Road During Transition, Christopher N. Jacques
The Prairie Naturalist
By now it is obvious to most of our members and authors that The Prairie Naturalist (TPN) has experienced some delays in conducting journal-related business over the past few months. Publication of the June 2016 issue was slightly delayed and the December 2016 was mailed much later than planned. So I wanted to update our members on the current status, and other aspects, of TPN. As most of you know, when I transitioned into the Editorship of TPN, one of my first orders of business was to secure a new publication venue for the journal. Fortunately, the Department …
Review Of Birds Of Montana By Jeffrey S. Marks, Paul Hendricks, And Daniel Casey,
2016
United States Fish and Wildlife Service, Lakewood, Colorado
Review Of Birds Of Montana By Jeffrey S. Marks, Paul Hendricks, And Daniel Casey, Scott G. Somershoe
The Prairie Naturalist
The Birds of Montana is an impressive-looking tome, that includes 659 pages, 155 color range maps, 73 illustrations of species, and 16 color photos of Montana’s habitats. Upon the first bend of the binding, the reader will quickly realize the impressive depth of detail and research that went into writing and completing this book. Although Montana is the fourth largest state, one of the least populated states, and has few “binoculars on the ground,” the state has a fascinating and extensive ornithological history. The Birds of Montana is not a field guide, but rather it is an astonishingly comprehensive reference …
