Investigating The Role Of The Basolateral Amygdala Plays In The Incubation Of Cue-Induced Cocaine Seeking Behavior,
2022
Rowan University
Investigating The Role Of The Basolateral Amygdala Plays In The Incubation Of Cue-Induced Cocaine Seeking Behavior, Claire Marie Corbett
Graduate School of Biomedical Sciences Theses and Dissertations
Cocaine use disorder is a chronic, relapsing brain disease. Sex and ovarian hormones are known to influence cocaine addiction liability and relapse vulnerability. However, little is known regarding the cellular and synaptic mechanisms contributing to sex differences in relapse vulnerability, including how these measures are influenced by hormonal fluctuations. To investigate sex differences in relapse vulnerability we use a rodent model of cocaine craving and relapse called the incubation model in which cue-induced seeking progressively increases or “incubates” during the first month of withdrawal from extended-access cocaine self-administration. Using this model, we have recently shown that females in the estrus …
An Assessment Of Burbot Life History In Minnesota With A Focus On Movement Dynamics And Spawning Vulnerability,
2022
Bemidji State University
An Assessment Of Burbot Life History In Minnesota With A Focus On Movement Dynamics And Spawning Vulnerability, Tyler Robinson
Biology Graduate Theses
Burbot have a circumpolar range spanning from rivers of Alaska to lentic systems in Minnesota. Although Burbot population dynamics have been studied, their movement dynamics have been rarely investigated. Our objectives were to assess seasonal home range changes of Burbot in a closed-lentic system and quantify the scale of spawning aggregations. Sixty-six Burbot were implanted with acoustic transmitters in Bad Medicine Lake, Minnesota, with 32 surviving the length of the study period between 10 April 2019 to 11 June 2020. The peak spawning date for Burbot in Bad Medicine Lake was estimated to be mid-March, when home range estimates were …
Efforts To Increase The Ketamine-Like Activity Of The Rapid-Acting Antidepressant Ro-25-6981 (Mi-4) By Increasing Ampa Potentiation,
2022
Roseman University of Health Sciences
Efforts To Increase The Ketamine-Like Activity Of The Rapid-Acting Antidepressant Ro-25-6981 (Mi-4) By Increasing Ampa Potentiation, Nathan Heger
Annual Research Symposium
The small molecule ketamine has generated much interest due to its rapid antidepressant effects. Despite having a rapid onset, ketamine has poor bioavailability, short duration of action, toxicities with long-term use, and a high potential for abuse. The molecule MI-4 (RO 25-6981) has also been shown to have both a rapid and sustained antidepressant effect. Most of the research into the mechanism of the rapid onset of MI-4 and ketamine has focused on their interaction with the NMDA receptor in addition to some monoamine transporters. Some recent publications have shown a significant role of AMPA receptors in the ketamine antidepressant …
A Quantitative Analysis Of The Efficacy Of Various Essential Oils Against The Sars Cov-2 Virus,
2022
Brigham Young University - Provo
A Quantitative Analysis Of The Efficacy Of Various Essential Oils Against The Sars Cov-2 Virus, Elizabeth Wagstaff, Chandrelyn Kraczek, Jack Brandon Lopez
Annual Research Symposium
A poster presentation and abstract for the Roseman Symposium. The project focuses on testing 3 essential oil blends and two disinfectants containing an essential oil blend against SARS CoV-2 in response to the COVID-19 pandemic. The project procedure involves plaque assays, disinfection, and neutralization techniques.
Trkb Activity Alters Voluntary Alcohol Consumption In Nondependent Mice,
2022
Noorda College of Osteopathic Medicine
Trkb Activity Alters Voluntary Alcohol Consumption In Nondependent Mice, Alfred Amendolara
Annual Research Symposium
No abstract provided.
Novel Methodology For The Investigation Of Dmrt3a Interneurons In Larval Zebrafish,
2022
Noorda College of Osteopathic Medicine
Novel Methodology For The Investigation Of Dmrt3a Interneurons In Larval Zebrafish, Alfred Amendolara
Annual Research Symposium
No abstract provided.
The Correlation Of D-Dimer To Stroke Diagnosis Within 24 Hours: A Meta-Analysis,
2022
Shalamar Medical and Dental College
The Correlation Of D-Dimer To Stroke Diagnosis Within 24 Hours: A Meta-Analysis, Adeel Ahmad, Zara Islam, Saad Manzoor Ahmad, Zouina Sarfraz, Azza Sarfraz, Miguel Felix, Ivan Cherrez-Ojeda
Department of Paediatrics and Child Health
Background: Diagnosing D-Dimer early is essential to optimize clinical treatment and quality of life and reduce mortality. This study aims to identify the difference of D-Dimer levels (ng/ml) in patients with stroke within the 6- and 24-h period compared to patients that mimic stroke.
Methods: An electronic database search across PubMed/MEDLINE, Cochrane, Web of Science, CINAHL, EMBASE, and Scopus was conducted until December 10, 2021. Studies were eligible if they included adult patients with stroke compared to stroke mimics or controls reporting D-Dimer values. Quality assessment was conducted using GRADE. The standardized mean difference and 95% confidence intervals were calculated …
Development Of A Multivariate Model With Desirability-Based Optimization For Determination Of Atenolol And Hydrochlorothiazide By Eco-Friendly Hplc Method With Fluorescence Detection,
2022
The British University in Egypt
Development Of A Multivariate Model With Desirability-Based Optimization For Determination Of Atenolol And Hydrochlorothiazide By Eco-Friendly Hplc Method With Fluorescence Detection, Ekram Hany Mohamed, Ahmed Hemdan,, Naser F. Al-Tannak,
Pharmacy
Determination of a widely used antihypertensive combination of atenolol and hydrochlorothiazide was achieved by rapid and eco-friendly high-performance liquid chromatography method combined with fluorescence detection. The response surface methodology is conducive to the complete separation of the two drugs in a shorter analysis time. The separation of the mixture was achieved using an Inertsil C18 analytical column (150 × 4.6 mm, 5 µ). The mobile phase used was ethanol: potassium dihydrogen phosphate at pH 3 (65:35 v/v) and the flow rate was 0.7 mL/min. The fluorescence detector operated at excitation and emission wavelengths of 230 and 310 nm (atenolol) and …
A Review Of Coronaviruses Associated With Kawasaki Disease: Possible Implications For Pathogenesis Of The Multisystem Inflammatory Syndrome Associated With Covid-19,
2022
Aga Khan University
A Review Of Coronaviruses Associated With Kawasaki Disease: Possible Implications For Pathogenesis Of The Multisystem Inflammatory Syndrome Associated With Covid-19, Fatima Farrukh Shahbaz, Russell Seth Martins, Abdullah Umair, Ronika Devi Ukrani, Kauser Jabeen, M Rizwan Sohail, Erum Khan
Medical College Documents
Multisystem Inflammatory Syndrome in Children (MIS-C), representing a new entity in the spectrum of manifestations of COVID-19, bears symptomatic resemblance with Kawasaki Disease (KD). This review explores the possible associations between KD and the human coronaviruses and discusses the pathophysiological similarities between KD and MIS-C and proposes implications for the pathogenesis of MIS-C in COVID-19. Since 2005, when a case-control study demonstrated the association of a strain of human coronavirus with KD, several studies have provided evidence regarding the association of different strains of the human coronaviruses with KD. Thus, the emergence of the KD-like disease MIS-C in COVID-19 may …
Characterization Of Testis-Derived Mesenchymal Cells And The Hunt For Universal Stemness Markers,
2022
The American University in Cairo AUC
Characterization Of Testis-Derived Mesenchymal Cells And The Hunt For Universal Stemness Markers, Myret Ghabriel
Theses and Dissertations
Mesenchymal stromal/stem cells (MSCs) are multipotent cells residing in multiple tissues with the capacity for self-renewal and differentiation into various cell types. Due to the myriad sources of MSCs the International Society for Cellular Therapy (ISCT) proposed certain criteria for their characterization. Here, we isolate adult MSCs from mouse testes and demonstrate that these testis-derived MSCs (tMSCs) follow some of the ISCT’s criteria. tMSCs expressed the MSCs surface markers CD44, CD73, and CD29 and lacked the expression of the hematopoietic cell marker CD45. Moreover, the cells displayed the capacity for self-renewal and in vitro differentiation into adipocytes. Since the isolation …
Lymphoma With Tuberculous Granulomas,
2022
Aga Khan University
Lymphoma With Tuberculous Granulomas, Jyoti Mohan Lal, Anila Rashid
Department of Pathology and Laboratory Medicine
Chronic granulomatous inflammation is a common finding in lymphoproliferative disorders (LPDs), but it is important to exclude coexisting mycobacterium tuberculosis (MTB) especially in patients from areas of high endemicity. This case emphasizes the relevance of performing MTB culture on bone marrow exhibiting LPD and concomitant granulomas
A Highly Selective And Sensitive Spectrofluorimetric Method For The Assessment Of 3-Nitrotyrosine In Serum Using (Eu(Tta)3phen) Photo Probe,
2022
The British University in Egypt
A Highly Selective And Sensitive Spectrofluorimetric Method For The Assessment Of 3-Nitrotyrosine In Serum Using (Eu(Tta)3phen) Photo Probe, Ekram Hany Mohamed, Mohamed S. S. Attia, Ahmed O. Youssef, Nour El-Din A. Abdel-Sattar, Mohammed A. Amin,, Sarah Alharthi, Safwat A. Mahmoud,, Mona N. Abou-Omar,
Pharmacy
A simple, accurate and fast method was developed for the assessment of 3-nitrotyrosine as a biomarker for the early diagnosis of liver cirrhosis with minimal hepatic encephalopathy (MHE) using a (Eu(TTA)3Phen) photo probe. 3-Nitrotyrosine can remarkably quench the luminescence intensity of the (Eu(TTA)3Phen) complex in DMSO at pH = 9 and λem = 617 nm. The quenching of the luminescence intensity of (Eu(TTA)3Phen) complex particularly the electrical emission band at λem = 617 nm is used for the assessment of 3-nitrotyrosine in different serum samples of patients with liver cirrhosis
Scientific Development Of An Integrated Workflow For Latent Print, Questioned Document, And Dna Processing Of Paper Evidence,
2022
CUNY Graduate Center
Scientific Development Of An Integrated Workflow For Latent Print, Questioned Document, And Dna Processing Of Paper Evidence, Ashley Morgan
Dissertations, Theses, and Capstone Projects
Touch paper evidence could be the source of probative human DNA but recovery is challenging and forensic laboratories instead prioritize processing by the Latent Print and Questioned Document disciplines. Recent advances in DNA collection methods and the increased sensitivity of STR typing kits have improved success rates for DNA testing of paper evidence; but prior to implementing DNA collection, laboratories have to decide in which order to examine paper for the different types of forensic evidence. This thesis developed and tested a multi-discipline workflow for processing paper evidence by DNA, Latent Prints and Questioned Documents experts. Preliminary sampling studies indicated …
Distribution Of Serotypes And Antibiotic Resistance Of Invasive Pseudomonas Aeruginosa In A Multi-Country Collection,
2022
University of Maryland School of Medicine
Distribution Of Serotypes And Antibiotic Resistance Of Invasive Pseudomonas Aeruginosa In A Multi-Country Collection, Shamima Nasrin, Nicolas Hegerle, Shaichi Sen, Joseph Nkeze, Sunil Sen, Jasnehta Permala-Booth, Myeongjin Choi, James Sinclair, Milagritos D. Tapia, Sadia Shakoor
Department of Pathology and Laboratory Medicine
Background: Pseudomonas aeruginosa is an opportunistic pathogen that causes a wide range of acute and chronic infections and is frequently associated with healthcare-associated infections. Because of its ability to rapidly acquire resistance to antibiotics, P. aeruginosa infections are difficult to treat. Alternative strategies, such as a vaccine, are needed to prevent infections. We collected a total of 413 P. aeruginosa isolates from the blood and cerebrospinal fluid of patients from 10 countries located on 4 continents during 2005-2017 and characterized these isolates to inform vaccine development efforts. We determined the diversity and distribution of O antigen and flagellin types and …
Evaluation Of A Shortened Redon Fit Test Protocol For Half-Mask Respirators,
2022
University of North Alabama
Evaluation Of A Shortened Redon Fit Test Protocol For Half-Mask Respirators, Olivia Dawson, Riley Duncan, Leshan J. Kimbrough
Scholar's Day
The purpose of this study was to investigate whether a shortened REDON method is as effective and accurate compared to the reference method when measuring respirator fit for elastomeric half-mask respirators using the Quantifit® CNP instrument.
Spatial And Temporal Variability Of Mercury In Upper And Lower Red Lake Walleye,
2022
Bemidji State University
Spatial And Temporal Variability Of Mercury In Upper And Lower Red Lake Walleye, Tyler Orgon
Biology Graduate Theses
Mercury is a global pollutant that is released into our environment by natural and anthropogenic processes resulting in extensive studies conducted on mercury cycling in aquatic ecosystems which has led to the issuance of human-health-based fish-consumption advisories. We examined total mercury concentrations in Walleye Sander vitreus from Upper and Lower Red Lakes, located in north central Minnesota, between 2019 and 2020. Upper and Lower Red Lake form a contiguous water body consisting of two large (483.1 and 665.6 km2, respectively) basins that are naturally connected by a 1.4 km-wide strait. Both basins are important fisheries for recreation, subsistence, and commercial …
Analysis Of Hematocrit Levels In Walleye Sander Vitreus From Similar Waterbodies,
2022
Bemidji State University
Analysis Of Hematocrit Levels In Walleye Sander Vitreus From Similar Waterbodies, Alyssa Hauser
Journal of Earth and Life Science
Walleye Sander vitreus are a popular fish among anglers and hold a prominent place in Minnesotan’s identity as their state fish. Because of this, multiple management practices are used to ensure the continued health of their populations within Minnesota waters. In this study, the process of analyzing hematocrit levels was used to determine if the analysis of hematological parameters could be a useful tool in detecting differences in population health. To evaluate this, blood samples were acquired from age-0 and age-1 fish from two similar lakes and run through a hematocrit centrifuge to separate platelets from plasma to read the …
The Effects Of Diet On Yellow Perch Morphology Throughout Lake Bemidji,
2022
Bemidji State University
The Effects Of Diet On Yellow Perch Morphology Throughout Lake Bemidji, Quiana L. Radaich
Journal of Earth and Life Science
Morphology is very important as it looks at the arrangement of an organism’s parts to determine their functionality, development, and how they could have changed through evolution. It is also important for the identification of species as it can show how closely species are related. This study examines if the morphology of yellow perch changes throughout Lake Bemidji. Along with examining a subset of five stomachs for each group (A-F) of yellow perch collected to determine if diet was a driving force behind morphological changes. The data collected in this study suggested that morphology does change throughout Lake Bemidji and …
Screening Ocean Samples From Georgia For The Presence Of Msx And Dermo Using Pcr And Qpcr Methods,
2022
University of New Hampshire
Screening Ocean Samples From Georgia For The Presence Of Msx And Dermo Using Pcr And Qpcr Methods, Olivia Michelle Williams
Honors Theses and Capstones
This Senior Thesis project aimed to be able to screen samples that came in from a PhD student in Georgia for the presence of two oyster diseases, MSX and Dermo. This study was done using PCR followed by visualizing on E-gels for initial presence of disease. These were then followed by qPCR and visualization on Criterion gels. These Criterion gels were able to be analyzed in order to calculate the pg/uL of MSX and Dermo in the original ocean samples. Since the samples were sent in over the course of February-August ‘21 the presence over time was also able to …
Safety In The Woods: Studying The Effectiveness Of The Kentucky Master Logger Program,
2022
University of Kentucky
Safety In The Woods: Studying The Effectiveness Of The Kentucky Master Logger Program, Austin Winn Leake
Theses and Dissertations--Community & Leadership Development
Logging is a dangerous field; in this study the researcher looks to see the knowledge both before and after professional loggers participate in the Kentucky Master Logger Program. This information was used to see the overall effectiveness of the Kentucky Master Logger Program. The researcher found an overall improvement in logging professionals’ perceptions and understanding of logging safety. The researcher recommends creating an emphasis on a safe work culture through safety incentives and a greater focus on less used personal protective equipment such as insecticide
