Life Sciences Commons^™

Immunomodulatory Effects And Marker Components Of Alcohol Extract From Acanthopanax Senticosus (Rupr . Et Maxim .) Harms- Ganoderma Applanatum (Pers.) Pat., Lihong Wang, Kairui Sheng, Ming Lu, Jin Su, Yang Ping, Yu Zhang, Ji Zhao, Yixia Gong

Journal of Food Science and Biotechnology

[Objective ] The aim of this study was to analyze the compositional changes of the alcohol extracts of Acanthopanax senticosus (Rupr.et Maxim.) Harms (APS )-Ganoderma applanatum (Pers.) Pat.(GA) before and after compounding at a mass ratio of 5∶1 (mAPS∶mGA=5∶1) and to investigate the immunomodulatory effects and marker components of the extracts.[Method ] The mouse models of compromised immunity and delayed-type hypersensitivity (DTH ) were established with cytoxan (CTX ) and 2,4-dinitrochlorobenzene (DNCB ),respectively,to investigate the effects of the alcohol extracts on the immune system.Ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS ) was used to analyze the changes of the active ingredients …

Effects And Differences Of (+)-Catechin And (-)-Epicatechin On Antioxidant Activity Of Hek 293t Cells, Chang Sun, Ning Xia, Chao Wang, Fengxian Qin, Chengyu Lyu, Jian Liu, Tiezhu Li

Journal of Food Science and Biotechnology

[Objective ] This study aims to investigate the effects and differences of the natural antioxidant (+)-catechin and its isomer (-)-epicatechin on the antioxidant activity of HEK 293T cells based on the nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE ) pathway.[Method ] The effects of (+)-catechin and (-)-epicatechin on the viability of HEK 293T cells were investigated via the methyl thiazolyl tetrazolium (MTT ) assay.Reporter genes were employed to investigate the regulatory effects on the activation of ARE.The effects of (+)-catechin and (-)-epicatechin on the mRNA and proteins levels of the downstream factors [glutamate-cysteine ligase modifier subunit (GCLM …

Effects Of Α-Amylase Addition On The Characteristics Of Infant Rice Flour, Huihui Liu, Zhiyong Dai, Mengyi Li, Jiao Peng, Xing Meng, Luyan Liao, Rongbin Zhang

Journal of Food Science and Biotechnology

[Objective ] This study aims to investigate the effects of α-amylase addition on the characteristics of infant rice flour.[Method ] Infant rice flour samples with different α-amylase addition were prepared.The basic composition,relative molecular mass of starch,gelatinization properties,hydration properties,texture properties,in vitro digestion characteristics,and microstructure of infant rice flour were determined.Furthermore,the correlations between the physicochemical characteristics and quality characteristics of infant rice flour were analyzed.[Result ] The weight-averaged molecular weight and the number-averaged molecular weight of starch in infant rice flour decreased with the increase in α-amylase addition.The gelatinization curve of infant rice flour with α-amylase addition was relatively gentle,and the gelatinization …

Effects Of Spices On Microbial Community Structure And Volatile Flavor Components Of Fuling Pickled Mustard Tuber, Ting Ren, Yuling Liu, Zhiping Zhao, Xiaoyong Chen, Yumei Peng, Hong Tao, Yuanli Luo

Journal of Food Science and Biotechnology

[Objective ] This study aims to investigate the effects of spices on the microbial community structure and volatile flavor compounds of Fuling pickled mustard tuber and explore the correlations between dominant microbial genera and volatile components.[Method ] The effects of spices on microbial community structure and volatile flavor components of Fuling pickled mustard tuber were investigated by high-throughput sequencing and headspace solid-phase microextraction (HS-SPME ) coupled with gas chromatography-mass spectrometry (GC-MS ).Pearson correlation coefficients were calculated to reveal the correlations between dominant microbial genera and volatile components.The mass fractions of total acids,nitrite,and reducing sugar were determined.[Result ] The dominant microbial …

Effects Of Shaping And Baking Processes On The Antioxidant Activity Of Round Roasted Green Tea, Jun Liu, Gong Feng, Rong Tan, Weihong Huang

Journal of Food Science and Biotechnology

[Objective ] This study investigated the effects of shaping and baking processes on the antioxidant activity of round roasted green tea,aiming to provide theoretical support and practical reference for improving the quality and optimizing the processing techniques of green tea.[Method ] The influences of different processing stages and key procedures such as shaping and baking on the antioxidant activity of round roasted green tea were studied.A zebrafish model (in vivo ) and multiple indexes including DPPH radical scavenging rate,ABTS ⁺ radical scavenging rate,and ferric ion reducing antioxidant power (FRAP ) were employed for comprehensive evaluation of the antioxidant activity.[Result ] …

Effects And Mechanisms Of Phytosterol-Oil Bodies Emulsion On Lipid Metabolism Of Caenorhabditis Elegans, Jie Sun, Mengyuan Yuan, Yifei Liu, Fuyao Zhang, Zhuofan Yang, Guoyou Yin

Journal of Food Science and Biotechnology

[Objective ] This study aims to explore the lipid-lowering effects of the phytosterol-oil bodies emulsion (POE ).[Method ] Caenorhabditis elegans was taken as a model to evaluate the effects of POE on lipid metabolism,physiological indexes,and expression of genes associated with oxidative stress and fat metabolism.[Result ] Compared with the control group,different mass concentrations of POE reduced the mass fraction of fat (P<0.01) and the relative content of triglycerides (P<0.05),without toxicity to the growth and development of C.elegans (P<0.01).At the same time,it significantly reduced the level of reactive oxygen species and increased the levels of antioxidant enzymes.In addition,POE affected the expression levels of genes related to fat metabolism.qPCR results showed that POE up-regulated the mRNA level of sbp-1,while down-regulating the mRNA levels of fat-2,nhr-80,and fat-5 (P<0.05).[Conclusion ] POE may improve lipid metabolism by slowing fat deposition,regulating the fat peroxidation pathway,and alleviating oxidative stress in C.elegans.

Optimization Of Processing Technology And Analysis Of Volatile Components In Jinxuan Black Tea Cream, Yunxian Wang, Yunxiong Zhao, Lianfeng Luo, Baogui Liu, Jingjing Yang

Journal of Food Science and Biotechnology

[Objective ] This study is intended to optimize the preparation process of Jinxuan black tea cream,enhance the content of tea polyphenols,and compare the effects of different processing methods on the volatile components of the tea cream.[Method ] With dried Jinxuan black tea as the raw material,response surface methodology was adopted to examine the impacts of tea-to-water ratio,enzyme dosage,ultrasonic power,and ultrasonic duration on the mass fraction of tea polyphenols in the black tea cream.Furthermore,headspace solid-phase microextraction (HS-SPME ) coupled with gas chromatography-mass spectrometry (GC-MS ) was employed to detect and analyze the volatile components in the black tea cream samples processed …

Optimization Of The Fermentation Medium Of Aneurinibacillus Jxn- 1 For Caproic Acid Production, Guangdong Gan, Chunlin Zhang, Ting Huang, Junjun He, Chun Pu, Wei Shi, Mingye Peng, Tengfei Zhao

Journal of Food Science and Biotechnology

[Objective ] This study aims to increase the caproic acid yield of Aneurinibacillus JXN- 1.[Method ] First,a Plackett-Burman design was employed to screen the significant factors affecting caproic acid yield from eight medium components.Subsequently,the path of steepest ascent method was used to determine the optimal concentration ranges of these significant factors.Finally,a Box-Behnken design was utilized to establish a quadratic polynomial regression model,and the interactions among the significant factors were analyzed to predict the optimal medium composition.[Result ] The Plackett-Burman design identified the mass concentration s of sodium acetate and calcium folinate and the volume fraction of ethanol as significant influencing …

Alirocumab In Dexamethasone-Induced Metabolic Syndrome: Therapeutic Benefits And Potential Hepatic Risks Through Rxr-Α / P-Akt Modulation, Miad A. Aljuhani, Mohamed S. Abdel-Bakky

Saudi Toxicology Journal

Background: Metabolic syndrome (MetS) elevates the risk of developing cardi-ovascular diseases and type 2 diabetes., driven by insulin resistance (IR), inflammation, and metabolic dysregulation. The PI3K/AKT pathway shows a key part in glucose and lipid metabolism. Alirocumab, a PCSK9 inhibitor, lowers LDL-C and improves IR but may cause hepatotoxicity. Aims: This study examines ali-rocumab’s effects on dexamethasone-induced MetS in rats, focusing on its metabolic benefits and potential liver toxicity. Methods: Over 30 days, 40 male Albino rats were distributed into control, Alirocumab, Dexamethasone, and Dexa-methasone+Alirocumab groups, with the latter receiving Dexamethasone to induce metabolic syndrome followed by Alirocumab administration. Results: …

Turfgrass Weed Control For Professionals, 2024, Aaron J. Patton, Matthew T. Elmore

Purdue University Press Books

Turfgrass is used on everything from athletic fields, golf courses, and parks, to lawns, sod farms, and roadsides. Unfortunately, information on weed management for professionals maintaining these areas has often been inaccurate or out of date, and applicators are frequently unaware of the most effective methods for controlling weeds in turf. Written by experts in the field and featuring insights from contributors from sixteen states across the US, the 2024 edition of Turfgrass Weed Control for Professionals was developed to provide science-based information for those working in the field. It contains information about turfgrass management, weed biology and management, more …

Imaging Features Of High-Grade Astrocytoma With Piloid Features: A Single Center Case Series, Heba Al Qudah, Jackson D Hamilton, Maria A Gubbiotti, Ahmed Msherghi, Hamza A Salim, Sahar Alizada, Ho-Ling Liu, Vinodh A Kumar, Max Wintermark, Rami W Eldaya

Faculty, Staff and Student Publications

High-grade astrocytoma with piloid features (HGAP) is a recently described IDH-wildtype tumor with limited literature describing its imaging features. We present our institution's experience and the largest imaging-focused cohort of HGAP reported to date, offering a comprehensive analysis of MRI features of seventeen intracranial and one spinal HGAP, while introducing novel imaging features that have not been previously described. These include focal areas of diffusion restriction, surrounding spiculated, finger-like enhancement and increased perfusion metrics. Additionally, we highlight imaging features of HGAP arising in patients with Neurofibromatosis Type 1, such as intraventricular tumor spread, unusual temporal lobe location and multifocal presentation.

Late Morbidity And Mortality In Survivors Of Childhood Ependymoma: A Report From The Childhood Cancer Survivor Study (Ccss), Katharine R Lange, Peter De Blank, Mengqi Xing, Sedigheh Mirzaei, Deo Kumar Srivastava, Kevin Oeffinger, Joseph Neglia, Kevin Krull, Paul C Nathan, Rebecca Howell, Kirsten K Ness, Lucie M Turcotte, Wendy Leisenring, Gregory T Armstrong, Tara Brinkman, Daniel C Bowers, Mehmet Fatih Okcu

Faculty, Staff and Student Publications

Background/objectives: Treatment of childhood ependymoma evolved from 1970 to 1999 by reducing radiation volumes and incorporating chemotherapy. The impact of these changes on long-term health outcomes remains unknown. In this report, we evaluated temporal changes in all-cause and cause-specific late mortality, chronic health conditions (CHCs), and subsequent neoplasms (SNs) in the Childhood Cancer Survivor Study (CCSS) cohort of adult survivors of pediatric ependymoma, diagnosed between 1970 and 1999.

Methods: A total of 404 five-year survivors of ependymoma (47.5% female, 80.7% non-Hispanic White, median 6 (range 0-20) years at diagnosis, 22 (5-49) years from diagnosis) diagnosed between 1970 and 1999 and …

Applied Research In Field Crop Pathology For Indiana, 2024, Darcy E. P. Telenko, Sujoung Shim

Purdue University Press Books

Applied Research in Field Crop Pathology for Indiana, 2024 serves as a summary of the applied field crop pathology research trials conducted in 2024 under the direction of the Purdue Field Crop Pathology program in the Department of Botany and Plant Pathology at Purdue University. In Indiana, there are more than 57,600 farms, 16,000 crop producers, and 900 certified crop advisers, Extension educators, and crop-protection industry representatives who manage more than 11.4 million crop-production acres with a total value of $6.3 billion annually. There are more than twenty diseases affecting corn, soybeans, and wheat that may decrease crop production and …

Seismic Responsive Buildings: Comparison Between Egyptian Code 2012 With Different International Codes For Seismic Structural Irregularities At Architectural Design, Aya Abd El Ghaffar Mohamed, Mohamed Anwar Mohamed Fikry, Mai Mohamed Abdo

Mansoura Engineering Journal

Seismic codes are laws and regulations that establish the basic requirements for building structures that can withstand seismic activity. Each country has different restrictions under different subheadings, depending on the seismic history of the region and the economic situation of the country. "Structural irregularity" is the most significant aspect of earthquake codes contributing to architectural design. A regular design of a structure leads to more rational behavior during earthquakes, enhancing resistance to dynamic loads and economic performance in comparison to irregular buildings. Architects must understand how earthquakes impact structures, as the structural system shapes the building's form and aesthetics, and …

How Can Smart Resilience Cities Provide Sdgs? An Integrative Framework Regarding Climate Change Mitigation, Asmaa M. Hassan, Manar A. Kotb

Mansoura Engineering Journal

Urbanization and climate change influence public health and wellbeing, which presents challenges facing architects and urban planners towards providing sustainable and resilient cities. In this context, smart city concept has been adopted to contribute to mitigating such influence. This study aims to conduct a bibliometric analysis within the previous scope. Then an integrative framework for climate change mitigation towards resilient smart cities based on SDGs is accomplished. The results indicate that further efforts are needed to develop “smart tools”, “urban economy”, and “carbon footprint. In addition, the proposed framework provides a significant paradigm shift towards mitigation of climate change impacts, …

Mmp-7 Expression And Rs11225307 Polymorphism In Breast Cancer And Fibroadenoma: A Molecular Study In Basrah, Iraq, Heba Jassam, Wijdan Nazar Ibraheim, Mazin Hawwaz Abdulridha, Rafid Adil Abood, Karam B. Nanjem

AUIQ Complementary Biological System

Breast cancer (BC) progression relies heavily on extracellular matrix degradation, mediated in part by matrix metalloproteinase-7 (MMP-7). While overexpression of MMP-7 has been implicated in multiple cancers, data from Middle Eastern populations remain limited.

This study examined MMP-7 gene expression and polymorphism patterns, with emphasis on rs11225307, in breast cancer versus benign fibroadenoma (FA) tissues among women in Basrah, Iraq. Thirty-seven BC and twenty-three FA patients were enrolled. MMP-7 mRNA expression was quantified using qRT-PCR and normalized to β-actin, while polymorphisms were analyzed through Sanger sequencing of eight SNPs and allele-specific PCR for rs11225307. Statistical significance was set at …

Population Structure Analysis Of Four Basal Higher-Attines Using Bioinformatic Approaches, Gabriel Mcdanield

Biology Theses

Metapopulations within the family Formicidae are unique among other animals due to the large colonies they build, and the mating strategies required to fertilize a specialized reproductive caste that will often produce young for the life of the colony. One group of ants, the fungus-gardeners (tribe Attini). The population structure of North American non-leafcutting, fungus-gardening ants has been understudied, especially in the southwest of the United States. Additionally, not much is known about their dispersal biology, so the dynamics of dispersal of these species and how they affect population structure is likewise not well known. To shed light on the …

Warmer Temperatures Increase Egg Laying And Egg Hatching Frequency In The Invasive Freshwater Snail Physa Gyrina From Pennsylvania, Usa, Peter Fong, Morgan Nieman

Biology Faculty Publications

Climate change continues to impact populations of organisms and to affect physiological adaptations to their environments. Freshwater snails have been so impacted globally, not only by climate change, but by the concomitant exposure to environmental pollutants like human antidepressants released from wastewater treatment plants. To test the effect of climate change and antidepressants, we exposed the freshwater snail, Physa gyrina to three temperatures (12 °C, 20 °C, and 25 °C) and to a concentration of the antidepressant fluoxetine, known to modulate snail behavior, and measured time to egg laying and egg hatching. Snails exposed to 20 °C and 25 °C …

First-Line Met Tyrosine Kinase Inhibitors Versus Immunotherapy ± Chemotherapy For Patients With Met Exon 14 Skipping Mutant Metastatic Nsclc, Federica Pecci, Hui Li, Alessandro Di Federico, Jia Wu, Hong Chen, Eleonora Gariazzo, Francesco Mantuano, Edoardo Garbo, Mihaela Aldea, Valentina Santo, Don Gibbons, Hai Tran, Francesco Paoloni, Guilherme Rossato De Almeida, Giulio Metro, Andrea De Giglio, Francesco Gelsomino, Xinan Wang, Marcello Tiseo, Julia Rotow, Andrea Ardizzoni, J Jack Lee, Mark M Awad, Alfredo Addeo, Lingzhi Hong, Marcelo V Negrao, Pasi A Jänne, John V Heymach, Jianjun Zhang, Biagio Ricciuti, Xiuning Le

Faculty, Staff and Student Publications

Purpose: First-line treatment options for MET exon 14 skipping-mutant metastatic non-small cell lung cancer vary because of differences in drug approvals and clinical experience. This study investigates factors influencing outcomes with first-line MET tyrosine kinase inhibitors (TKI) versus immune checkpoint inhibitors (ICI) ± chemotherapy.

Experimental design: Clinicopathologic data were collected from patients with metastatic MET exon 14 skipping-mutant non-small cell lung cancer treated with first-line MET TKI or ICI ± chemotherapy at five centers. Primary endpoints were real-world progression-free survival (rwPFS) and overall survival (OS) to first-line MET TKI versus ICI ± chemotherapy. Subgroup analyses by clinical and tumor characteristics …

Dog Snapper (Lutjanus Jocu) Neurocranium, Camila Avila Escobar, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Season-Long Time-Series Analysis Of Soil Respiration In Furrow-Irrigated Corn With And Without Cover Crop In The Lower Mississippi River Basin, Diego Della Lunga, Kristofor Brye, Michael J. Mulvaney, Mike Daniels, Tabata De Oliveira, Beth Baker, Timothy Bradford, Chandler Arel

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Temporal resolution of carbon dioxide (CO2) release from the soil at the field scale is not completely understood. The objectives of this study were to identify trends, repetitive cycles, and residual patterns and structures with a time-series analysis from a furrow-irrigated corn (Zea mays L.) field with and without cover crops (i.e., CC and No-CC, respectively) over the course of one growing season in the Lower Mississippi River Basin. Carbon dioxide fluxes were measured from 5 May to 18 August 2024, four times a day (i.e., 0300, 0900, 1500, and 2100 h) from each of the two CC treatments. Linear …

Chronosort: Revealing Hidden Dynamics In Alphafold3 Structure Predictions, Matthew J. Argyle, William P. Heaps, Corbyn Kubalek, Spencer Gardiner, Bradley C. Bundy, Dennis Della Corte

Faculty Publications

Protein function emerges from dynamic conformational changes, yet structure prediction methods provide only static snapshots. While AlphaFold3 (AF3) predicts protein structures, the potential for extracting dynamic information from its ensemble predictions has remained underexplored. Here, we demonstrate that AF3 structural ensembles contain substantial dynamic information that correlates remarkably well with molecular dynamics simulations (MD). We developed ChronoSort, a novel algorithm that organizes static structure predictions into temporally coherent trajectories by minimizing structural differences between neighboring frames. Through systematic analysis of four diverse protein targets, we show that root-mean-square fluctuations derived from AF3 ensembles can correlate strongly with those from MD …

Integration Of Marker-Assisted And Field Selection In Developing Tgms Lines For Hybrid Rice In The Southern United States, Ehsan Shakiba, Dustin G. North

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Hybrid rice adoption in the southern United States, especially Arkansas, requires thermo-sensitive genic male sterile (TGMS) lines that combine stable sterility with glabrous foliage and grain quality preferred in U.S. markets. Over seven years (2014–2021), three TGMS lines—UAS3023, UAS20, and UAS4208—were developed through integration of marker-assisted and field-based selection targeting blast resistance (Pi-ta, Pi-b), semi-dwarf stature (sd1), amylose content, and gelatinization temperature. UAS3023 and UAS20 expressed ≥ 99% sterility at ~ 29 °C, while UAS4208 was sterile at ~ 32 °C, thresholds consistent with controlled-environment studies. All lines showed semi-dwarf stature, lodging resistance, glabrous leaves, and ~ …

Effect Of Freezing And Freeze-Thaw Cycles On Equine Serum Insulin Concentration: A Pilot Study, Molly Wallace, Shea Porr, Lydia O'Sullivan

Honors College Theses

Insulin dysregulation is a key component of Equine Metabolic Syndrome (EMS), and is often a predisposing factor to conditions such as laminitis and hepatic lipidosis. Diagnosis of EMS is most often reached through a combination of glucose and insulin measurements in equine serum. Achieving an accurate result of insulin concentration is vital for diagnosis, making proper sample handling essential. The aim of this project was to evaluate the effect of repetitive freeze-thaw cycles on equine serum insulin concentrations. Serum was collected from 10 university-owned horses and split into four treatment groups: Unfrozen, Once Frozen, Twice Frozen, and Thrice Frozen. Unfrozen …

Oligomeric Cystatin C Supports The Immunosuppressive Activity Of Myeloid Cells Through Interaction With Inhibitory Receptors, Chengcheng Zhang, Yubo He, Xiaoye Liu, Jingjing Xie, Meng Fang, Xing Yang, Ryan Huang, Qi Lou, Bufan Li, Ankit Gupta, Cheryl Lewis, Marc I Diamond, Ningyan Zhang, Zhiqiang An, Cheng Cheng Zhang

Faculty, Staff and Student Publications

Amyloid proteins are linked to various diseases; however, their functional roles in immunity and cancer remain unclear. Here, we establish a direct link between oligomeric cystatin C-a cysteine cathepsin inhibitor and a well-characterized amyloidogenic protein-within the tumor microenvironment and the immune inhibitory receptors LILRB2 and LILRB5 on myeloid cells. We demonstrated that human LILRB2 and LILRB5, along with their murine counterpart PIRB, serve as functional receptors for cystatin C oligomers. Engagement of these inhibitory receptors by oligomeric cystatin C enhances the immunosuppressive activity of myeloid cells, leading to T-cell suppression and tumor progression. Deletion of the CST3 gene, which encodes …

Assessing Aerobic And Anaerobic Thresholds With Emphasis On Isocapnic Buffering In Endurance Runners, Yahya Mushaflar Fathi, Seyed Houtan Shahidi Dr., Prof. Dr. Mohamed Twfeq Othman Alhusaen Aga

International Journal of Exercise Science

International Journal of Exercise Science 18(5): 1381-1392, 2025. https://doi.org/10.70252/IYED1370 Accurate determination of metabolic thresholds is essential for designing effective endurance training. This study aimed to apply a multi-visit Step–Ramp–Step (SRS) protocol to identify aerobic (VT1) and anaerobic (VT2/RCP) thresholds in trained endurance runners, with a particular focus on delineating the isocapnic buffering region—the ventilatory phase between VT1 and VT2 where carbon dioxide (PetCO₂) remains stable despite rising ventilation. Twelve trained male runners (mean age: 27.1 ± 1.9 years; VO₂max: 60.5 ± 2.1 ml·kg⁻¹·min⁻¹) completed the SRS protocol across separate lab visits. Each session included a 4-minute moderate-intensity phase, a progressive …

Black Grouper (Mycteroperca Bonaci) Neurocranium, Layla Lacelle, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Rabies Virus-Vectored Lyme Disease Vaccine Provides Long-Term Protection Against Tick-Transmitted Borrelia Burgdorferi, Shantel Rios, Bibek Bhattachan, Christoph Wirblich, Anisha Chandwani, Kruthi Vavilikolanu, Jacob F. Myers, Chrysoula Kitsou, Utpal Pal, Matthias J. Schnell

Department of Microbiology and Immunology Faculty Papers

Lyme disease (LD) cases have doubled globally. LD is a tick-borne illness caused by the Borrelia burgdorferi sensu lato (Bb). If untreated, Bb can disseminate to distal organs, causing carditis, arthritis, and meningitis. Currently, no FDA-approved human LD vaccine exists on the market. This study used two approaches to incorporate OspA into the rabies virus (RABV) vaccine vector. We used the RABV-glycoprotein tail (RVG tail) and the Hendra virus (HeV) glycoprotein tail (HVG tail) to incorporate OspA, creating BNSP333-OspA-RVG and BNSP333-OspA-HVG, respectively. Both vaccines produced type-1 biased anti-OspA antibodies, but only BNSP333-OspA-HVG induced neutralizing antibodies and protected against Bb infection. …

Primary Intramedullary Spinal Melanocytomas: Case Report And Review Of Clinical Features, Diagnosis, And Management, Gil Kimchi, Samantha Varela, Juan Pablo Zuluaga-Garcia, Francisco Call-Orellana, Esteban Ramirez Ferrer, Romulo Augusto Andrade De Almeida, Maria A Gubbiotti, Isabella C Glitza, Andrew J Bishop, Jonathan D Grant, Robert Y North, Christopher A Alvarez-Breckenridge, Laurence D Rhines, Claudio E Tatsui

Faculty, Staff and Student Publications

Objective: Intramedullary melanocytomas are extremely rare spinal cord tumors with distinct histopathological and imaging characteristics. This report reviews the literature on this pathology and presents a representative case study, highlighting aspects of diagnosis and management.

Methods: A scoping review of PubMed, Web of Science, and Embase databases was conducted to identify reports on intramedullary melanocytomas, focusing on clinical presentation, imaging features, histopathology, treatment, and outcomes. Case reports and case series were included due to the rarity of these tumors.

Results: Twelve manuscripts met the inclusion criteria, including 15 patients. In the majority of patients, intramedullary melanocytomas present with progressive myelopathy …

The Unfolded Protein Response-Novel Mechanisms, Challenges, And Key Considerations For Therapeutic Intervention, P M Quan Mai, Tam-Anh Truong, Sai Kumar Samala, Bhoomika Muruvekere Lakshmisha, Prapannajeet Biswal, Khadijeh Koushki, Prudhvi Chand Mallepaddi, Geraldine Vijay, Sunil Krishnan

Faculty, Staff and Student Publications

Background: The unfolded protein response (UPR) is an evolutionarily conserved, synchronized, and orchestrated process triggered by eukaryotic cells in response to endoplasmic reticulum (ER) stress. UPR restores the ER's capacity to handle large protein loads within it, and still fold and process these proteins accurately. Many recent studies have documented the non-canonical roles of the UPR, outside of protein quality control, in the context of lipid metabolism and the immune system in cancer. Cancer cells have been known to hijack the UPR to promote survival and evade immune surveillance. However, the underlying mechanisms remain poorly understood.

Objectives: Here, we critically …