Life Sciences Commons^™

Electrochemical Sensors For In Situ Monitoring Of Reactive Species During Cold Atmospheric Plasma-Based Therapies, Jonathan Thomas, Suneel Kumar, Gagana Karkada, Julia Sutter, Kristina Pattison, Jason Rainone, Dhruv Patel, Shashank Madhavan, Fred Krebs, Francois Berthiaume, Vandana Miller, Katharina Stapelmann

Kimmel Cancer Center Faculty Papers

Cold atmospheric pressure plasma (CAP) is emerging as a clinically relevant therapy for dermatological conditions such as actinic keratosis, warts, and chronic wounds. However, these therapies lack strategies to monitor CAP delivery in situ and to ensure delivery of an effective CAP dose without unwanted toxicity. CAP acts as a therapeutic agent in these biomedical applications primarily (but not solely) through reactive oxygen and nitrogen species (RONS) generated at transiently high local concentrations. Here we demonstrate the use of bio-electrochemical sensors capable of real-time measurements of key CAP RONS: hydrogen peroxide and oxidation-reduction-potential (ORP). In in vitro scratch assays and …

Citizen's Rare Plant Watch 2025 Recap, Nora Dunkirk

Rae Selling Berry Seed Bank and Plant Conservation Program

Citizen's Rare Plant Watch (CRPW) is a community science program which takes volunteers out to visit populations of rare and threatened Oregon native plant species. Volunteers assess their health and viability, update the Oregon Biodiversity Information Center (ORBIC) state database for rare species, and help contribute to data driven management decisions throughout the state. Housed at Portland State University, this program is open to the public and attracts plant lovers from diverse backgrounds. Each spring, CRPW trains volunteers on methods of data collection, and this year we implemented new technology using Survey123 to streamline population assessments. We focus on species …

The Effectiveness Of Telemedicine As A Pivotal Tool In Providing Accessible Medical Care, Peyton Wilt

Honors Theses

Telemedicine has emerged as one of the most transformative innovations in modern healthcare, offering new opportunities to bridge long-standing gaps in access, quality, and continuity of care. Rural and underserved communities in the United States face persistent barriers to healthcare, including provider shortages, geographic isolation, limited access to specialty services, transportation challenges, and socioeconomic disparities. These structural barriers often delay diagnosis, disrupt chronic disease management, and worsen overall health outcomes. Telemedicine provides a mechanism to address many of these obstacles by enabling remote consultations, real-time monitoring, follow-up appointments, and access to specialty providers through digital platforms.

This thesis examines the …

The Need To Incorporate Polysubstance Use In Neuropsychopharmacology Research: Biological Lessons And New Opportunities, Max E. Joffe, Susan M. Ferguson, Nick W. Gilpin, Melissa A. Herman, Lori A. Knackstedt, Patrick A. Randall, Abigail G. Schindler, Mary M. Torregrossa, Jennifer A. Rinker

School of Medicine Faculty Publications

Critical evaluation and refinement of animal models is essential for neuroscientists to understand complex physiological and pathological processes related to psychiatric diseases. In general, preclinical studies modeling drug dependence and problematic substance use have been limited to the administration of a single substance; however, there is a growing appreciation that this approach has failed to capture the complexities of humans and has stifled translational efforts. Polysubstance use represents the overwhelmingly common patterns of alcohol and drug use in humans. For example, epidemiological studies generally determine that between 70–95 % of individuals with alcohol use disorder use tobacco daily, and upwards …

Advancing Louisiana's Cropping Systems: Sustainable Bioenergy Production, Cover Crops, And Technology Integration, Pedro R. Carrillo

LSU Doctoral Dissertations

The adoption of cover crops in Louisiana is lower than the national average, underscoring the need for region-specific research to address environmental challenges and demonstrate the short-term benefits of these practices within existing production systems. This research evaluated the integration of cover crops (CC) in energy cane (Saccharum spp.) and no-till cotton systems, focusing on their effects on soil health, nitrogen (N) management, and biomass production. Soil health indicators (SHIs), including enzymatic activities (β-glucosidase, β-glucosaminidase, and urease), protein N, inorganic N concentrations (nitrate and ammonium), soil organic matter (SOM), and microbial community composition assessed through ester-linked fatty acid …

Analysis Of Source–Sink Organ Dynamics In Kaffir Lime (Citrus Hystrix Dc.) At Different Plant Ages, Siti Auliya Rahma, Rahmat Budiarto, Syariful Mubarok

Jurnal Kultivasi

Kaffir lime (Citrus hystrix DC.) is a leafy spice commodity widely used as a culinary ingredient, in bio-pharmaceuticals, and as a raw material for essential oil production. Despite its high demand, leaf productivity remains relatively low, highlighting the need for improved cultivation practices. A better understanding of source–sink dynamics is essential, as leaf production is strongly influenced by the balance between assimilate-producing and assimilate-consuming organs. Therefore, this study aimed to evaluate the source-sink capacity of kaffir lime plants of different ages as a preliminary step toward identifying cultivation strategies to enhance leaf production. The experiment was conducted at Bale Tatanen …

Comparative Analysis Of Color, Texture, And Water Content In Three Shallot Cultivars At Different Harvest Ages, Rahma Wati Lestari, Kusumiyati, Syariful Mubarok

Jurnal Kultivasi

Shallots are a major horticultural commodity with high economic value. The quality of shallots is determined not only by the quantity of the harvest but also by physical characteristics such as bulb color, texture, and water content. This study aims to evaluate the differences in these physical parameters in three popular local cultivars: Brebes, Sumenep, and Tuktuk, harvested at 56, 63, and 70 days after planting (DAP), respectively. This research uses a Randomized Block Design consisting of 9 treatment combinations and analyzed using the SmartstatXL application. Color measurements are conducted using the CIELAB method and converted to CIELCH and RGB …

Role Of Nano Edible Coating, Packaging, And Storage Temperature In Maintaining Color, Moisture Content, And Phenolic Compounds Of Straw Mushroom, Kiki Nuratni Sitompul, Syariful Mubarok, Kusumiyati

Jurnal Kultivasi

Straw mushrooms are among the most sought-after edible mushrooms, but their harvest is highly perishable due to their high respiration and transpiration rates, leading to a decline in quality during storage. The application of nano edible coating can cover the surface of straw mushrooms and maintain their freshness, while packaging and storage at low temperatures can maintain quality by inhibiting respiration and enzymatic activity. This study aims to evaluate the effects of nano edible coating, packaging types, and different storage temperatures on the color, moisture content, and phenolic compounds of straw mushrooms. The study was conducted at the Horticulture Laboratory, …

A Review Of Bioactive Compounds Of Caesalpinia Sappan: Pre- And Post-Harvest Effect, Annisa Lugina Rachman, Santi Rosniawaty, Syariful Mubarok, Cucu Suherman, Yudithia Maxiselly

Jurnal Kultivasi

Sappanwood (Caesalpinia sappan L.) is a shrub or small tree that thrives in tropical regions and has been widely distributed across various areas. It has long been used as a natural dye in textiles, cosmetics, and herbal beverages due to its content of various bioactive compounds. This literature review discusses the secondary metabolites in sappanwood, their health benefits, and strategies to enhance product quality through pre-harvest and post-harvest treatments. This literature review was conducted by searching for relevant journals on Google Scholar using relevant keywords. Sappanwood contains diverse secondary metabolites, including flavonoids, phenolics, anthraquinones, triterpenoids, steroids, alkaloids, and tannins, with …

Circulating Tumor Dna Refines Risk Stratification Of Neoadjuvant Therapy-Resistant Breast Tumors, Mark Jesus M Magbanua, Nayelis A Manon, Denise M Wolf, Samuel Rivero-Hinojosa, Ziad Ahmed, Rosalyn W Sayaman, Antony Tin, Derrick Renner, Ekaterina Kalashnikova, Lamorna Brown-Swigart, Gillian L Hirst, Christina Yau, Wen Li, Claudine Isaacs, Rebecca A Shatsky, Amy S Clark, Alexandra Zimmer, Amy L Delson, Angel Rodriguez, Minetta C Liu, Paula R Pohlmann, Laura J Esserman, Hope S Rugo, Angela Demichele, Laura Van 'T Veer

Faculty, Staff and Student Publications

Early-stage breast cancers resistant to neoadjuvant therapy (NAT), characterized by high residual cancer burden (RCB) after treatment, have an increased risk of metastatic recurrence. Here, we show that circulating tumor DNA (ctDNA) detected using a tumor-informed test (1) can improve risk stratification of patients with NAT-resistant tumors (RCB-II/RCB-III) and (2) predict response to NAT. Stratification using ctDNA status at pretreatment or post-NAT and ctDNA dynamics identified NAT-resistant tumors with a significantly decreased risk of metastatic recurrence. ctDNA clearance as early as week 3 across receptor subtypes predicted favorable responses to NAT, including immunotherapies. Interestingly, less than a fifth of patients …

Single Cell Spatial Profiling Of The Matrisome Identifies Region-Specific Adhesion And Signaling Networks In Glioblastoma, Arpan De, Santiago A Forero, Ali Pirani, John E Morales, Marisol De La Fuente-Granada, Sumod Sebastian, Jason T Huse, Leomar Y Ballester, Jeffrey S Weinberg, Frederick F Lang, Kadir C Akdemir, Joseph H Mccarty

Faculty, Staff and Student Publications

The human brain contains a milieu of extracellular matrix (ECM) components that promote normal development and physiology. ECM signaling pathways are often dysregulated in brain pathologies including the malignant cancer glioblastoma (GBM). Here, we used single-cell spatial transcriptomic platforms to map the expression of nearly 400 ECM genes in matching non-cancerous brain and GBM samples. At least four different GBM cell populations have been identified that show unique ECM expression profiles and spatial enrichment in distinct intratumor regions. Spatial mapping demonstrates largely non-overlapping expression signatures of ECM components in GBM stromal cell types, particularly in vascular endothelial cells and microglia/macrophages. …

Geoscience Letters: From Founding Vision To Shaping The Future Of Geoscience, James Terry, Cheng‐Ku Yu

All Works

No abstract provided.

Current Threat To The Native Endemic Muckalee Crayfish (Procambarus Gibbus) From An Invasive Crayfish (Faxonius Palmeri Creolanus) And Tests Of Cold Tolerance As A Limiting Factor, Alexandria L. Exum, Nickeya Wynn, William Ellerbee, Madaline Toth, Otto T. Lorenz

Georgia Journal of Science

Surveys for native and invasive crayfish were conducted in Muckalee creek in 2015 and 2021. Both surveys used passive minnow traps and examined upstream and downstream sites, including at the mouth of the creek where it connects with the Flint River. The Flint River has been overrun with an invasive crayfish species, Faxonius palmeri creolanus (Creole Painted Crayfish) and its range has spread rapidly throughout southwest Georgia. In Muckalee Creek there were only a few F. p. creolanus found during each survey and both times they were only found at the mouth of the creek. One hypothesis on why they …

Ink And Ignorance: How Limitations In Research, Captivity And Recognition Obscure Cephalopod Science, Jacob Weniger

Saint John’s Preparatory School Student Work

This paper analyzes what the limitations are in modern ocean research and how they relate to the study of cephalopods. To understand this, the paper reviews many known cephalopod species to understand what is unknown about their biology. Research was then conducted to assess why certain aspects of species are unknown. Then each gap the specifications of the limitation and the solutions or strategies to overcome them was examined. This led to examinations of research tools, analysis bias, and public views. Understanding these issues is of great importance because it gives a comprehensive lay out of what needs to be …

Update To: New Butterfly Taxa And Findings From Genomic Analyses, Jing Zhang, Qian Cong, Jinhui Shen, Leina Song, Nick V. Grishin

The Taxonomic Report of the International Lepidoptera Survey

Due to the United States government shutdown, GenBank services were unavailable, and accession numbers could not be obtained for the sequences reported in the original publication. This update provides the GenBank accession numbers for these sequences, together with additional taxonomic findings accumulated since the initial study. One genus, 16 species and four subspecies are proposed as new (type species or localities in parentheses): Madaga Grishin, gen. n. (Artitropa alaotrana Oberthür, 1916), Udranomia eurianus Grishin, sp. n. (Ecuador: Napo), Entheus dalina Grishin, sp. n. (Brazil: Pará), Entheus ambo Grishin, sp. n. (Colombia: Cauca), Entheus pico Grishin, sp. n. (Colombia: Valle …

You Have To Cut&Walk; Before You Can Cut&Run;: Regulation Of Gene Expression By The Vitamin D Receptor (Vdr) In The Annual Killifish, Austrofundulus Limnaeus, Rosalia Tanori

Dissertations and Theses

The annual killifish, Austrofundulus limnaeus, found in ephemeral ponds in South America, possesses a remarkable ability to survive extended periods without water and oxygen. This ability is associated with developmental dormancy known as diapause. Numerous genetic and environmental factors influence the entry into diapause and tolerance to environmental stress. Among these is vitamin D3 signaling mediated by the vitamin D receptor (VDR), which plays a crucial role in regulating entry into diapause and the continuous development of an embryo in a temperature-dependent manner. Vitamin D3 signaling influences a variety of physiological processes in vertebrates. While extensively characterized in mammalian …

Spike Timing Depended Plasticity Produces Unsupervised Learning Of Synergistic Muscle Feedback In A Synthetical Neural Network, Mark Allen Pupkiewicz

Dissertations and Theses

This study investigates how type Ia feedback from muscle spindles can be organized into groups representing agonistic muscle pairs through Spike Timing Dependent Plasticity (STDP). A single degree of freedom joint is actuated with four biologically modeled muscles forming two agonistic pairs. In order to emulate the sensory dynamics of biological muscle spindles, sensors in the model record the active length and velocity states of each muscle, the two primary factors eliciting type Ia afferent responses. In biological networks, synapses from Ia sensory neurons frequently activate interneurons representing agonistic muscle sources. This research investigates whether this organization can emerge in …

Mechanistic Modelling And Parameter Estimation Of Heterogeneous Catalytic Synthesis Of Green Fuel, Rasheed U. Owolabi, Obinna P. Anele, Mohammed A. Usman

Mansoura Engineering Journal

Investigation of the kinetics and mechanistic modelling of biodiesel synthesis through the reaction of castor oil with methanol under catalyzed conditions was carried out in this study. The reaction mechanisms of the Eley-Rideal, Langmuir-Hinshelwood-Hougen-Watson, and Hattori type were employed to identify the rate-determining or controlling step of the reaction. Thirteen rate expressions were developed for reactant adsorption, product desorption, and surface chemical reactions. The experimental data from Sanchez-Cantu et al. were used to validate the models, and the best-fitting model and parameter estimation were evaluated using SAS and MATLAB software. From the results, the Eley-Rideal mechanism with glycerol desorption as …

The Timing Of Pubertal Onset Affects Adults Anxiety Behavior In A Sex-Specific Manner, Evan Raubenolt

Honors Projects

This study aims to look at the relationship between the timing of pubertal onset and its long-term effects on adult anxiety behavior in rats. Though the topic of pubertal onset has been frequently discussed in developmental research, its exact effects have been inconsistent. Human models have shown that early and late maturing males are associated with a notable increase in adult anxiety behavior, while in rat models, similar sex-specific effects regarding anxiety have been demonstrated, though those studies focus on a causal relationship between exposure to stress and age of pubertal onset. This study first aims to examine that relationship …

Thriving Hives: The Apiary - Beekeeping Essentials, Joseph Okoh, Andree' Walker Bravo

All Current Publications

This fact sheet is designed to help honey bee producers optimize their beekeeping practices and improve management systems. It offers essential guidance on selecting an ideal apiary location, choosing the right beehive, and ensuring efficient colony management. Additionally, this document serves as a valuable training resource for aspiring beekeepers.

The Compatibility And Contribution Of Natural Enemies In Western Us Alfalfa Management, Ricardo A. Ramirez, Scott A. Bernhardt, Ryan A. Larsen

Funded Research Records

No abstract provided.

Collaborative Research: Evolving Thicker Skin: Understanding How Adaptations To A Universal Trade-Off Dictate The Climate Vulnerability And Ecology Of An Imperiled Vertebrate Clade, Molly Womack

Funded Research Records

No abstract provided.

Compost Composition Effects On Microbial Communities, Deep Carbon, And Nutrient Cycling In Organic Dry-Land Wheat Systems, Astrid Rosa Jacobson

Funded Research Records

No abstract provided.

Investigation Of The Endogenous Opioid Neural Circuitry In Pain, Erin Nicole Bobeck

Funded Research Records

No abstract provided.

Usu Subaward: Creation Of A Cooperative Bs Degree Program For The Marianas Islands And Beyond, Abby Benninghoff

Funded Research Records

No abstract provided.

Ecological Drivers Of Habitat Selection And Maternal Survival In Female Mule Deer (Odocoileus Hemionus), Brady R. Knight

Theses and Dissertations

Understanding the ecological and biological factors that influence habitat selection by mule deer (Odocoileus hemionus) is crucial for effective management. Mule deer select cover, forage, and water, each critical to energy acquisition and survival of mule deer. Here, we evaluate the factors that influence habitat selection and reproductive decisions by mule deer . In chapter one we evaluate the influence of treatments to restore quaking aspen (Populus tremuloides) on habitat selection by mule deer. We hypothesized that mule deer would not use habitats randomly because of variability in nutrition and perceived risk of predation. We predicted that areas with aspen …

Mitochondrial Insoluble Aggregates In Aging And Alzheimer’S Disease Models: Cross-Species Proteomic Integration, Identification Of Conserved Candidates, And Pharmacological Disruption Of Eef-2 Interactions, Sonu Pahal

Theses and Dissertations

Protein aggregation within mitochondria emerges early in both aging and Alzheimer’s disease (AD) and contributes to progressive loss of proteostasis. Insoluble mitochondrial aggregate fractions from Caenorhabditis elegans revealed extensive enrichment of metabolic and translational proteins that also appear in human Alzheimer hippocampal aggregates. Comparative analysis across age and genotype identified a conserved subset of aggregation-prone proteins, several of which cluster around elongation factor 2 (eEF-2), a regulator of ribosomal translocation and energy coupling. Cross-species integration defined a network in which eEF-2 links chaperones, metabolic enzymes, and RNA-binding proteins that co-aggregate in both human Alzheimer material and nematode models. Functional tests …

Space Agriculture: A Comprehensive Systems-Level Review Of Challenges And Opportunities, Hassan Fazayeli, Aaron Lee M. Daigh, Cassandra Palmer, Santosh Pitla, David Jones, Yufeng Ge

Biological Engineering Faculty Publications

As humanity prepares for prolonged space missions and future extraterrestrial settlements, developing reliable and resilient food-production systems is becoming a critical priority. Space agriculture, the cultivation of plants beyond Earth (particularly on the Moon and Mars), faces a constellation of interdependent environmental, biological, and engineering challenges. These include limited solar radiation, elevated ionizing radiation, large thermal variability, non-Earth atmospheric pressures, reduced gravity, regolith substrates with low nutrient-holding capacity, high-CO₂/low-O₂ atmospheres, pervasive dust, constrained water and nutrient availability, altered plant physiology, and the overarching need for closed-loop, resource-efficient systems. These stressors create an exceptionally challenging environment for plant …

A Framework For Improving Analysis And Modeling Of Earth System And Intersectoral Dynamics At Regional Scales, Shih-Yu Wang

Funded Research Records

No abstract provided.

Collaborative Research: Seed-Fungal Interactions: Uncovering Functional Specificity And Primary Symbionts As Key Drivers Of Tropical Tree Recruitment, Noelle Beckman

Funded Research Records

No abstract provided.