Life Sciences Commons^™

Assessing The Economic Impacts Of The Illegal, Unreported And Unregulated Fishing On The Namibian Coastal Communities : Challenges And Mitigation Strategies, Susana Kashinashilonga Angula

World Maritime University Dissertations

No abstract provided.

Assessing The Effectiveness Of Extension Services On Aquaculture Development In Ashanti Region, Ghana, Bismark Essel

World Maritime University Dissertations

No abstract provided.

Evaluating The Fisheries Observer Program Of Guyana’S Seabob Trawl Fishery : Insights Into Scientific Aspects And Onboard Working Conditions, Kadesha Shawyana Nedd

World Maritime University Dissertations

No abstract provided.

The Role Of Marine Spatial Planning (Msp) In Managing Conflicts Between Marine Resource Users In Tanzania, Ramadhani Juma Shausi

World Maritime University Dissertations

No abstract provided.

Gilbert’S Potoroo And The Fun-Guys: Co-Existing Mycophagous Mammals As Indicators Of Potentially Available Fungal Food Resources, Rebecca J. Quah, James Anthony Friend, Aaron J. Brace, Saul J. Cowen, Robert A. Davis, Harriet R. Mills, Anna J.M. Hopkins

Research outputs 2022 to 2026

Understanding resource use and availability is critical for the success of wildlife translocations, especially for species with complex diets. Mycophagous (fungus-feeding) diets are particularly challenging to study due to the difficulty in identifying fungal species, many of which remain undescribed. Environmental DNA (eDNA) metabarcoding techniques applied to scat samples, offer a promising solution to overcome the limitations of traditional dietary analysis involving microscopic identification of undigested material in scats. This allows for the detailed characterization of fungal composition in the diets of mycophagous species. Here we present results of a dietary study focused on Gilbert’s potoroo (Potorous gilbertii) that also …

Screening For Potential Plant Growth‐Promoting Rhizobacteria (Pgpr)-Assisted Phytoremediation To Mitigate Lead Toxicity In Uae Soils, Zeinab Mohamed Abdalla

Theses

This study investigates the potential of lead (Pb)-tolerant actinobacteria that possess 1-aminocyclopropane-1-carboxylate deaminase (ACCD) activity and plant growth-promoting (PGP) traits to serve as a biological tool for enhancing the growth of corn (Zea mays L.) under Pb stress. The primary objective of this research was to isolate and characterize novel, Pb-tolerant, rhizosphere-competent actinobacteria and to evaluate their efficacy in mitigating Pb toxicity, reducing its uptake, and promoting biomass accumulation in corn grown in contaminated soil. A total of 43 actinobacterial isolates were obtained from Pb-contaminated rhizosphere soil and screened for Pb tolerance, rhizosphere competence, ACCD activity, and PGP traits. …

Dairy And Food Science News, Nov 2025, Department Of Dairy And Food Science

Dairy & Food Science News

Message from the Department Head
Holiday Cheese Boxes
We are Hiring
Dairy and Food Science Department in the Media
Education abroad program to India - Food and Agriculture Processing: India SDSU Fall 2026
Faculty Updates
Surveys and Studies
Recruitment Updates and Opportunities
SDSU Company Student Recruitment
Student Updates
Alumni Spotlight
Events and Calendar

Small For Gestational Age Subgroups Have Differential Morbidity, Growth, And Neurodevelopment At Age 2: The Interbio-21st Newborn Study, Aris T. Papageorghiou, María C. Restrepo-Ménde, Rose Mcgready, Fernando C. Barros, Francois Nosten, Shama Munim, Roseline Ochieng, Rachel Craik, Hellen C. Barsosio, Zulfiqar Ahmed Bhutta

Department of Obstetrics & Gynaecology

Background: Small for gestational age is a complex perinatal syndrome associated with increased neonatal morbidity, mortality, and impaired childhood growth and neurodevelopment. Current classifications rely primarily on birthweight, which does not capture the heterogeneity of the condition nor predict long-term health outcomes. Here we aim to identify and characterize distinct small for gestational age subgroups and assess their neonatal and early childhood health trajectories.
Objective: To refine the classification of small for gestational age by identifying subgroups based on maternal, fetal, and environmental factors and evaluating their associations with neonatal morbidity, growth, and neurodevelopment at age 2.
Study design: Prospective …

‘Earth System Engineers’ And The Cumulative Impact Of Organisms In Deep Time, Simon A. F. Darroch, Michelle M. Casey, Alison T. Cribb, Amanda E. Bates, Matthew E. Clapham, Dori L. Contreras, Matthew Craffey, Ivo A. P. Duijnstee, William Gearty, Nicholas J. Gotelli, Marcus J. Hamilton, Riley F. Hayes, Pincelli M. Hull, Daniel E. Ibarra, V. A. Korasidis, Jaemin Lee, Cindy V. Looy, Tyler R. Lyson, Benjamin Muddiman, Peter D. Roopnarine, Alex B. Shupinski, Felisa A. Smith, Alycia L. Stigall, Catalina P. Tomé, Katherine A. Turk, Amelia Villaseñor, Peter J. Wagner, Steve C. Wang, S. Kathleen Lyons

College of Life Sciences Faculty Papers

Understanding the role of humans as 'ecosystem engineers' requires a deep-time perspective rooted in evolutionary history and the fossil record. However, no conceptual framework exists for studying the rise of ecosystem engineering in deep time, requiring us to consider effects that fall outside the scope of traditional definitions. Here, we present a new framework applicable to both modern and ancient engineering-type effects. We propose a new term - 'Earth system engineering' - to describe biological processes that alter the structure and function of planetary spheres, and which combines core tenets of ecosystem engineering, niche construction, and legacy effects. We illustrate …

3d Printed Microscopes As A Low-Cost Alternative To Conventional Light Microscopes, Aidan W. Donelan, Hunter N. Lemer, Sudeshna Roy, Nicholas C. Butzin

iLEARN Teaching Resources

Many K-12 schools function on limited budgets in their science departments, making it difficult to acquire, maintain, and update microscopes. While modern light microscopes are often complex, expensive, and require specialized training, they are based on simple principles of light. Microscopes enable us to observe objects too small for the naked eye and reveal intricate details. Introducing affordable, easy-to-use microscope adaptations early in education helps foster a deeper understanding of science and encourages young students to pursue STEM fields. Using 3D printing, we developed two innovative microscope models and two lesson plans. Lesson 1: Using a smartphone microscope to visualize …

Brain-Wide Patterns Of Crf Receptor 1 Expression In The Transgenic Crfr1-Cre-2a-Tdtom Rat, Douglas S Engelke, Lierni Ugartemendia, Jonathan Tao, Shivakumar Rajamanikam, Fabricio H Do Monte, Nicholas J Justice

Faculty, Staff and Student Publications

The ability to manipulate neurons that express corticotropin-releasing factor (CRF) or its receptors has led to many new discoveries about how CRF signaling modulates stress-related behaviors in mice. However, similar advances in rats have been limited by the lack of reporter lines targeting CRF receptors, restricting access to behavioral paradigms that are more suitable for, or specific to, rats. Here, we provide an extensive neuroanatomical characterization of a recently generated CRFR1-Cre rat. We show that Cre and tdTomato are expressed in a pattern that closely aligns with previously reported CRFR1 expression patterns, as determined by in situ hybridization in rats …

Acute Kidney Injury Is Associated With Elevated Urinary Endotrophin, Amanda J Clark, Brenda Mendoza Flores, Marie Christelle Saade, Kyle Q Vu, Isaac J Pence, Ningyan Zhang, Zhiqiang An, Dawei Bu, Philipp E Scherer, Samir M Parikh

Faculty, Staff and Student Publications

Acute kidney injury (AKI) is prevalent among hospitalized patients. Novel biomarkers are needed to diagnose AKI and target therapies. Endotrophin (ETP) is a molecule released during collagen type VI formation that may promote injury and fibrosis. Although serum ETP elevation has been associated with adverse outcomes in AKI, urinary ETP has not been assessed in AKI, nor has ETP been evaluated in a pediatric population. Urine samples were collected from a tertiary children's hospital. Medical records were reviewed, and patients who met criteria were sorted into three categories:

Opposing Roles Of Microglial And Macrophagic C3ar1 Signaling In Stress-Induced Synaptic And Behavioral Changes, Ashutosh Tripathi, Alona Bartosh, Dania Jose, Jocelyn Mata, Usama Hussein, Fernanda Laezza, Zhongming Zhao, Anilkumar Pillai

Faculty, Staff and Student Publications

The social deficits following chronic stress conditions are linked to synaptic dysfunction in the brain. Complement system plays a critical role in synapse regulation. Although complement has been implicated in chronic stress-induced behavior deficits the cellular substrates and mechanisms underlying complement-mediated behavior changes under chronic stress conditions are not known. In the present study, we investigated the role of complement component 3a receptor (C3ar1) in microglia and monocytes/macrophages (Mo/MΦ) in chronic unpredictable stress (CUS)-induced synapse loss and behavior deficits in mice. We found that deletion of microglial C3ar1 attenuated stress-induced social behavior deficits and changes in neuroinflammatory as well as …

Damslnet: Dual-Attention Multi-Scale Lightweight Network For Plant Disease Classification, Linfan Deng, Juan Qin, Kun Li, Jinhua Zhu, Zhaoxia Wang

Research Collection School Of Computing and Information Systems

Accurately identifying crop diseases plays a crucial role in advancing intelligent and modern agricultural production. Deep learning techniques have performed robust performance in classifying plant disease images. However, current studies face the challenge that many plant disease datasets are generated in controlled environments, leading to reduced model performance in real-world agricultural settings. This paper aims to provide a lightweight model that can accurately classify plant diseases in natural environments. Specifically, this paper investigates the Dual-Attention Multi-Scale Lightweight Network (DAMSLNet), which combines dual-attention-based multi-scale feature extraction and deep information fusion, to classify plant diseases. At the front end, the model employs …

Khsrp-Mediated Decay Of Axonally Localized Prenyl-Cdc42 Mrna Slows Nerve Regeneration, Matthew D. Zdradzinski, Lauren S. Vaughn, Samaneh Matoo, Kayleigh Trumbull, Terika P. Smith, Davis Noblitt, Courtney N. Buchanan, Ashley Loomis, Elizabeth Thames, Seung Joon Lee, Nora Perrone-Bizzozero, Qun Lu, Jessica M. Larsen, Jeffery L. Twiss

Faculty Publications

The small GTPase CDC42 promotes axon growth through actin filament polymerization and this growth is driven by axonal localization of the mRNA encoding the prenylated CDC42 isoform (Prenyl-Cdc42). Here, we show that axonal Prenyl-Cdc42 mRNA levels and the mRNA's translation are decreased by growth-inhibiting stimulation and increased by growth-promoting stimulation. In contrast, axonal RhoA mRNA transport and translation are increased by growth-inhibiting but unaffected by growth-promoting stimuli. Localized increase in KHSRP in response to growth inhibitory stimulation, through elevation of intracellular Ca2+, promotes decrease in axonal levels of Prenyl-Cdc42 mRNA. Distinct 3'UTR motifs regulate transport and axonal levels of Prenyl-Cdc42 …

Western Australia’S Primary Industries: 2021-22 Economic Overview, D. Maharjan, S. Akbari, A K. Abadi Ghadim, P. Mattingley, I. Wilkinson, J. Tan, J. Van Staden, M. Radhakrishnan

All other publications

The Western Australia’s Primary Industries: 2021-22 Economic Overview (WAPIEO) is developed by DPIRD in partnership with the Forest Products Commission.

The WAPIEO has a trade focus and provides a single source for consistent statistics and insights on observed industry trends.

The WAPIEO is based primarily on 2021-22 economic indicators from the Department of Treasury, DPIRD data, and statistics from the Australian Bureau of Statistics (ABS), in line with the release cycle dates of final ABS data.

Restricting Metabolic Plasticity Enhances Stress Adaptation Through The Modulation Of Pdh And Hif1a In Trap1-Depleted Colon Cancer, Hong-Yuan Tsai, Miao-Hsueh Chen, Jihye Yun, Lisa A Lai, John F Valentine, Mary P Bronner, Teresa A Brentnall, Sheng Pan, Ru Chen

Faculty, Staff and Student Publications

Metabolic plasticity allows cancer cells to survive under adverse conditions. To investigate the role of mitochondrial chaperone tumor necrosis factor receptor-associated protein 1 (TRAP1) in this process, we used CRISPR/Cas9 mediated genetic deletion to knock out (KO) TRAP1 in colon cancer cells. Depletion of TRAP1 triggered a series of events: induced metabolic reprogramming, increased glycolytic flux, downregulation of mitochondrial complex I, and elevated ROS generation. TRAP1-deficient cells showed tolerance to Oxidative Phosphorylation (OXPHOS) inhibitors and exhibited a higher extracellular acidification rate (ECAR). Additionally, TRAP1 depletion activated hypoxia response elements (HREs) and upregulated HIF1A target genes such as GLUT1 and MCT1. …

Biophysical Processes Of Morphogenesis In Lizard Lungs, Kaleb Hill, Aaron H. Griffing, Michael A. Palmer, Bezia Lemma, Aria S. Lupo, Tony Gamble, Natalia A. Shylo, Andrej Kosmrlj, Paul A. Trainor, Celeste M. Nelson

Biological Sciences Faculty Research and Publications

Background

The lungs of squamate reptiles (lizards and snakes) are highly diverse, exhibiting single chambers, multiple chambers, transitional forms with two to three chambers, along with a suite of other anatomical features, including finger-like epithelial projections into the body cavity known as diverticulae. During embryonic development of the simple, sac-like lungs of anoles, the epithelium is pushed through the openings of a pulmonary smooth muscle mesh by the forces of luminal fluid pressure. This process of stress ball morphogenesis generates the faveolar epithelium typical of squamate lungs.

Results

Here, we compared embryonic lung development in brown anoles, leopard geckos, and …

Consumers Stabilize Grassland Ecosystem Functions By Destabilizing Belowground Communities Under Abiotic Stress, Jane M. Lucas, Michelle L. Budny, Nathan P. Lemoine

Biological Sciences Faculty Research and Publications

Consumers play a critical role in mediating plant and ecosystem responses to abiotic stress, yet their influence on belowground processes under changing environmental conditions remains underexplored. Insect consumers are vital components of grassland ecosystems that can shape ecosystem function and stability by mitigating how plant and microbial communities respond to abiotic stress, like drought. This study investigates how small-bodied consumers influence the magnitude and stability of grassland belowground functions across gradients of abiotic stress. We conducted a fully factorial field experiment manipulating consumer presence and induced drought over a growing season. Our results reveal that the presence of consumers stabilizes …

Minimum Standards Of Maturity For Table Grapes 2025-2026, Department Of Primary Industries And Regional Development, Western Australia

Viticulture research reports

The table shows the approved minimum standard of maturity for each of the standard varieties listed when tested using the approved method. The approved method for testing these varieties is to test the brix (sugar level) of the fruit using a refractometer.

Detection And Classification Of Invasive Callery Pear From Multisource Satellite Imageries In Google Earth Engine, Kavi Raj Awasthi, Nilesh Timilsina, Denita Hadziabdic, Federico Iuricich, William E. Klingeman, Marcin Nowicki, Brook T. Russell, Jessica A. Hartshorn

Publications

Assessing the spatial distribution of invasive species is a critical component for establishing baselines to examine the rate of spread, documenting key areas where negative impacts on ecosystems can be mitigated, and developing sustainable management strategies. Callery pear (Pyrus calleryana Decne.; PC) is a rapidly spreading invasive woody plant species in the eastern United States (U.S.). The incursion of these wild-type trees into urban, peri-urban, and rural landscapes, which have escaped from transplanted clonal cultivars, poses complex management challenges for land managers and hampers ecosystem function by competing with native plant species and altering the forest environment. We integrated …

Expanding Functionalities Of Immune Receptors Through Simultaneous Transfer Of Sensor And Helper Nlrs, Dongjiao Wang, Qibin Wu, Daowen Wang, Youxiong Que, Zheng Qing Fu

Faculty Publications

No abstract provided.

Risk Score Roulette: A Cautionary Tale Of Polygenic Risk Score Reliability, Diane Xue, Elizabeth E Blue, Alexis C Wood, Jerome I Rotter, Alison E Fohner

Children’s Nutrition Research Center Staff Publications

Genetic risk prediction for Alzheimer's disease (AD) has high potential impact, yet few studies have assessed the reliability of various polygenic risk score (PRS) methods at the individual level. Here, we evaluated the reliability of AD PRS estimates among 6338 participants from the Multi-Ethnic Study of Atherosclerosis. We compared four PRS models that have been previously associated with dementia risk. Despite similar population-level performance metrics, inter-model reliability of individual-level risk assessment was low, even among individuals classified in the top and bottom deciles. These findings raise serious concerns about the downstream application of PRS for guiding interventions for AD.

Pathogenic Xpo1 Variants Cause A Dominant Neurodevelopmental Disorder, Amber S E Van Oirsouw, Pavla Nedbalova, Miroslava Hancarova, Jan Prchal, Darina Prchalova, Marketa Vlckova, Sarka Bendova, Kristin G Monaghan, Lisa M Dyer, Yanmin Chen, Deanna Alexis Carere, Emma A M Te Bogt, Heather Fisher, Angela E Scheuerle, Stephanie Riley, Mahim Jain, Weiyi Mu, Joann N Bodurtha, Albertien M Van Eerde, Marijn F Stokman, Nicola Longo, Meena Balasubramanian, Michael Spiller, Gregory Costain, Charlotte Von Der Lippe, Kristian Tveten, Marianne Jortveit, Øystein L Holla, Bertrand Isidor, Benjamin Cogné, Kevin E Glinton, Blake Vuocolo, Roberta Ann Sierra, Brad Angle, Kelly Bontempo, Klaas Koop, Rachel Rabin, John Pappas, David A Staffenberg, Pascal Joset, Peter Miny, Isabel Filges, Abdulrazak Alali, Kara Vitalone, Jill A Rosenfeld, Weimin Bi, Samuel Bradbrook, Renee Perrier, Subhadra Ramanathan, June-Anne Gold, María Palomares Bralo, María Ángeles Gómez-Cano, Ann Haskins Olney, Shelly Nielsen, Alban Ziegler, Dominique Bonneau, Clément Prouteau, Ange-Line Bruel, Charlotte Caille-Benigni, Laëtitia Lambert, Andrea C Yu, Nathaniel H Robin, Dana Goodloe, Jan Fischer, Joseph Porrmann, Yvonne D Hennig, Rami Abou Jamra, Isabella Herman, Ivy R Johnson, Lucas Hérissant, Guillaume Jouret, Koen L I Van Gassen, Ellen Van Binsbergen, Bert Van Der Zwaag, Alwin Kamermans, Renske Oegema, Zdenek Sedlacek, Michaela Fenckova, Richard H Van Jaarsveld

Faculty, Staff and Students Publications

Purpose: XPO1 functions in key cellular processes, including nucleo-cytoplasmic export and mitosis. The gene is deleted in a subset of patients with the 2p15p16.1 microdeletion syndrome; however, no monogenic XPO1-related disorder has been described to date.

Methods: We collected clinical data of individuals with de novo XPO1 variants through online matchmaking. We used Drosophila to study XPO1 function in development and habituation learning.

Results: A total of 22 individuals met the criteria to be included in the main study cohort. Of these, half have putative loss-of-function variants, and half have coding variants (10 missense and 1 in-frame deletion variant). We …

Glycerol-3-Phosphate Activates Chrebp, Fgf21 Transcription And Lipogenesis In Citrin Deficiency, Vinod Tiwari, Byungchang Jin, Olivia Sun, Edwin D J Lopez Gonzalez, Min-Hsuan Chen, Xiwei Wu, Hardik Shah, Andrew Zhang, Mark A Herman, Cassandra N Spracklen, Russell P Goodman, Charles Brenner

Faculty, Staff and Students Publications

Citrin deficiency (CD) is caused by the inactivation of SLC25A13, a mitochondrial membrane protein required to move electrons from cytosolic NADH to the mitochondrial matrix in hepatocytes. People with CD do not like sweets. Here we show that SLC25A13 loss causes the accumulation of glycerol-3-phosphate (G3P), which activates the carbohydrate response element-binding protein (ChREBP) to transcribe FGF21, which acts in the brain to restrain intake of sweets and alcohol and to transcribe key genes driving lipogenesis. Mouse and human data suggest that G3P-ChREBP is a mechanistic component of the Randle Cycle that contributes to metabolic-dysfunction-associated steatotic liver disease and forms …

Molecular Mechanisms In Masld/Mash-Related Hcc, Xiaobo Wang, Liang Zhang, Bingning Dong

Faculty, Staff and Students Publications

Liver cancer is the third leading cause of cancer-related deaths and ranks as the sixth most prevalent cancer type globally. NAFLD or metabolic dysfunction-associated steatotic liver disease, and its more severe manifestation, NASH or metabolic dysfunction-associated steatohepatitis (MASH), pose a significant global health concern, affecting approximately 20%-25% of the population. The increased prevalence of metabolic dysfunction-associated steatotic liver disease and MASH is parallel to the increasing rates of obesity-associated metabolic diseases, including type 2 diabetes, insulin resistance, and fatty liver diseases. MASH can progress to MASH-related HCC (MASH-HCC) in about 2% of cases each year, influenced by various factors such …

Chemical Modulation Of Gut Bacterial Metabolism Induces Colanic Acid And Extends The Lifespan Of Nematode And Mammalian Hosts, Guo Hu, Marzia Savini, Matthew Brandon Cooke, Xin Wei, Dinghuan Deng, Shihong M Gao, Ruyue Alps Xia, Youchen Guan, Alice X Wen, Xin Yu, Jin Wang, Chao Jiang, Christophe Herman, Jiefu Li, Meng C Wang

Faculty, Staff and Students Publications

Microbiota-derived metabolites have emerged as key regulators of longevity. The metabolic activity of the gut microbiota, influenced by dietary components and ingested chemical compounds, profoundly impacts host fitness. While the benefits of dietary prebiotics are well-known, chemically targeting the gut microbiota to enhance host fitness remains largely unexplored. Here, we report a novel chemical approach to induce a pro-longevity bacterial metabolite in the host gut. We discovered that wild-type Escherichia coli strains overproduce colanic acids (CAs) when exposed to a low dose of cephaloridine, leading to an increased life span in the host organism Caenorhabditis elegans. In the mouse gut, …

Enhancement Of Antimicrobial Activity Of Truncated Cecropin B Peptides With The Substitution Of Tryptophan Residues, Sarah Smith, Christopher Feudale, Josephina R. Vermillion, Joseph Feudale, Joshua Do, Sabrina Arroyo, Juan Barrera, Madeleine Whitsitt, Marion Duval, Colby Grames, Bret Hatzinger, Makenzie Hilling, Tia Kean, Jasayle Rivera, Mia Shum, Hannah Zyra, David Rovnyak, Moria C. Chambers

Faculty Journal Articles

Cecropins are a class of antimicrobial peptides (AMPs) expressed by insects that have broad-spectrum antimicrobial activity and low cytotoxicity. However, cecropins are also long (40–45 amino acids) peptides, making their adaptation for therapeutic use challenging. Here, we present a series of 16 amino acid-long peptides derived from cecropin B from Drosophila melanogaster. The native truncated peptide is cationic and expected to form an amphipathic α-helix, but does not have antimicrobial activity. The incorporation of two Trp residues, depending on the position in the peptide backbone, results in antibacterial activity compa-rable to that of full-length cecropin B against the gram-negative bacteria …

Isolation And Characterization Of Plant Growth Promoting Rhizobacteria From Soils In The Uae And Their Effect On Plant Salt Tolerance, Layla Zayed Almazrouei

Theses

Plants are constantly challenged by environmental stresses that restrict their growth and productivity. In the United Arab Emirates (UAE), soil salinity is a critical barrier to agriculture, particularly for tomato (Solanum lycopersicum), which is highly sensitive to moderate salinity levels (>2.5 dS m⁻¹). This study explored the potential of plant growth–promoting rhizobacteria (PGPR), especially actinobacteria, to enhance salt tolerance in tomato. The objective was to evaluate the effects of rhizosphere-competent (RC) and non-rhizosphere-competent (NRC) PGPR on plant physiology and yield in saline sandy soils. Actinobacterial strains were isolated from the tomato rhizosphere and screened to produce 1-aminocyclopropane-1-carboxylic …

Genomic And Metabolic Network Characterization Of Fusarium Species, Hend Hussain Mueenuddin

Theses

Fusarium covers the wide genus of fungi with over 400 species that are key in agricultural and medical practice. The purpose of the current study was to perform a comprehensive genomic profiling of the 19 Fusarium species that were captured in the National Centre of Biotechnology Information (NCBI) database. The study was made to make a comparison of the data, based on the descriptive statistics of every species, with graphical representation images enabling clear demonstration of the numbers. The study indicated that the chromosomal numbers were in the range of 0-15, the gene count was roughly 11000 -19000, while that …