Life Sciences Commons^™

Recombination Mediator Proteins: Misnomers That Are Key To Understanding The Genomic Instabilities In Cancer, Justin Courcelle, Travis K. Worley, Charmain Courcelle

Biology Faculty Publications and Presentations

Recombination mediator proteins have come into focus as promising targets for cancer therapy, with synthetic lethal approaches now clinically validated by the efficacy of PARP inhibitors in treating BRCA2 cancers and RECQ inhibitors in treating cancers with microsatellite instabilities. Thus, understanding the cellular role of recombination mediators is critically important, both to improve current therapies and develop new ones that target these pathways. Our mechanistic understanding of BRCA2 and RECQ began in . Here, we review the cellular roles of RecF and RecQ, often considered functional homologs of these proteins in bacteria. Although these proteins were originally isolated as genes …

Challenges In Gluten Analysis: A Comparison Of Four Commercial Sandwich Elisa Kits, Plaimein Amnuaycheewa, Lynn Niemann, Richard E. Goodman, Joseph L. Baumert, Steve L. Taylor

Department of Food Science and Technology: Faculty Publications

Gluten is composed of prolamin and glutelin proteins from several related grains. Because these proteins are not present in identical ratios in the various grains and because they have some differences in sequence, the ability to accurately quantify the overall amount of gluten in various food matrices to support gluten-free labeling is difficult. Four sandwich ELISAs (the R-Biopharm AG R5 RIDASCREEN®, the Neogen Veratox® R5, the Romer Labs AgraQuant® G12, and the Morinaga Wheat kits) were evaluated for their performance to quantify gluten concentrations in various foods and ingredients. The Morinaga and AgraQuant® G12 tests yielded results comparable to the …

Strategies To Promote Responsive Bottle-Feeding In Wic Predict Less Frequent Use Of Food To Soothe And Healthier Weight Status For Infants With Negative Temperaments, Alison K. Ventura, Shannon E. Whaley

Kinesiology and Public Health

Background: Infants with greater temperamental negative affectivity are at higher risk for overfeeding and excess weight gain.

Objective: To examine whether strategies to promote responsive bottle-feeding within WIC promoted healthier maternal feeding practices and infant weight status among infants with greater negative affectivity.

Methods: Secondary analysis of data from a matched-pair cluster randomized trial. Policy, systems and environmental change (PSE) strategies to promote responsive bottle-feeding were implemented at three WIC clinics; these clinics were compared with three matched control clinics. Linear mixed models tested whether infant negative affectivity interacted with PSE strategies to predict feeding and weight outcomes when infants …

Pastoralists’ Perception Of Poverty: A Case Of The Somali And Turkana Of Northern Kenya, W. P. Watete, Kogi-Makau

IGC Proceedings (1977-2023)

Poverty is a complex phenomenon, without a single definition or standard methods of reducing it. Income based methods of assessing poverty have been shown to have limitations that undermine their application in measuring and attacking poverty among pastoral households. Stages of progress method of poverty assessment was used to assess poverty among pastoral households in Turkana and Mandera Counties of Northern Kenya. Three hundred and three hundred and fifty-four households in Mandera and Turkana Counties respectively were sampled across three different livelihood zones: pastoral, agro-pastoral and off-farm. Accumulation of livestock was regarded as a key indicator of wealth among pastoral …

Pastoralist Conservation: Local Ecological Knowledge And Collective Action For Grassland Conservation In Sierra De Segura (Spain), P. Sanosa-Cols, F. Ravera, F. Dominguez, M. Ventura

IGC Proceedings (1977-2023)

Even if Pastoralism is not practised anymore by a majority of families in the Sierra de Segura (south-eastern Andalusia, Spain), it is still considered a paradigmatic way of life and management of its highlands and a key cultural heritage deeply rooted in local identity. In this article we explore two pastoral communities of this region, Santiago and Pontones, with their body of situated knowledge of the territory and natural resources, which helps pastoralists to organize their livelihoods, while requiring collective organization to manage access to grasslands. Through an ethnographic research based on participant observation and in-depth interviews, we explore the …

Intensification Of Pastoralism As A Driver Of Degradation In The Algerian Steppe, S. Bencherif, P. Manzano

IGC Proceedings (1977-2023)

Land degradation linked to pastoralism use has been a worldwide concern for decades. A biological approach has often been use to understand such phenomena, usually disregarding economic and social factors. Radical transformations of pastoralism at the Algerian steppe constitute a good case study to provide an integrated understanding and to better orient development in other pastoralist areas across the world. Different actions by the public sector since the 1960s, as well as the land legislation adopted and the strong agricultural subventions during 2000-2010, have favored a massive conversion of land and resource management. This translates into conversion of many pastures …

Perceptions Of Rangeland Degradation In The Peruvian Altiplano Dry Puna And Implications, C. Turin, J. Gilles

IGC Proceedings (1977-2023)

The Peruvian altiplano’s dry puna is the main feed source for specialized alpaca pastoralist systems. Experts argue that rangelands are severely degraded and have formulated policies and programs to address this. However, these programs have had little success. This paper presents a qualitative case study of the perceptions of rangeland degradation held in three Aymara communities, by range scientists of academia, personnel of NGOs operating in the region and by government officers. We found that each of these groups had distinct views of the level and causes of degradation in the region. Differences in perceptions undermined cooperation and trust between …

Endangered Sustainable Innovation: Indigenous Milk Hygiene And Preservation Techniques By Maasai Too Valuable To Lose, J. Y. Laffa, C. R. Mcculloch, D. Schoder

IGC Proceedings (1977-2023)

The indigenous Parakuyo Maasai communities of Tanzania are traditional pastoralists who depend on fresh cow’s milk as a staple food. However, the arid climate and a lack of clean water challenge milk production and conventional milk hygiene practices.

By conducting informational interviews in eight Parakuyo Maasai regions and 13 districts of Tanzania we sought to identify the key indigenous plants preferred and establish their traditional manner of use. A semi-structured questionnaire was designed to: (i) determine the plants used, (ii) the parts used, (iii) methods of preparation and utensil smoking, (iv) therapeutic applications and associated health benefits of these plants, …

Using Personality And Temperament To Predict Exercise Behavior: A Pilot Study Of The Braverman Nature Assessment, Ben M. Rosicky, Eric E. Hall

International Journal of Exercise Science

International Journal of Exercise Science 15(5): 341-357, 2022. The Braverman Nature Assessment (BNA) is intended to determine the dominant monoamine neurochemical that drives an individual’s temperament and behavior. The measure has been colloquially praised for the ability to determine the most effective exercise protocols for an individual based on their “dominant nature.” This study seeks to examine the proposed relationship between the Braverman Natures and exercise behavior. Seventy-three adults (57 females) between ages 18-65 (mean = 26 years) completed an online survey consisting of the BNA, Big Five Personality Inventory (BFI), and Aerobics Center Longitudinal Study Physical Activity Questionnaire (ACLSPAQ). …

Chronic Effects Of Heavy Load Activity Performed Before Resistance Training Sessions On The Physical Performance Of Youth Soccer Players, Guilherme Borsetti Businari, Julio Benvenutti Bueno De Camargo, Paulo Henrique Barbosa, Felipe Alves Brigatto, Marcelo Saldanha Aoki, Tiago Volpi Braz, Charles Ricardo Lopes

International Journal of Exercise Science

International Journal of Exercise Science 14(6): 1421-1434, 2021. The adoption of resistance training (RT) programs has been shown to positively influence sports performance-related parameters. However, the chronic effects of maximal strength protocols on the performance of soccer players are not completely investigated. The aim of this study was to evaluate the effects of performing two repetition maximum (2RM) before a resistance training session on the physical performance of youth soccer players. Seventeen players (under-20 category) were allocated in one of the following groups: 2RM + resistance training group (2RM + RT, n = 8) and resistance training group (RTG, n …

Comparison Of The Local Temperature, Lactate And Glucose After Three Different Strength Training Methods, Felipe J. Aidar, Dihogo Gama De Matos, Raphael Fabricio De Souza, Marcelo Danillo Matos Dos Santos, Anderson Carlos Marçal, Eduardo Borba Neves, Breno Guilherme De Araujo Tinoco Cabral, Victor Machado Reis

International Journal of Exercise Science

International Journal of Exercise Science 14(4): 1408-1420, 2021. This study aimed to evaluate the local temperature, lactate, and blood glucose in three strength training methods. The study included 12 male subjects; (22.15 ± 5.77 years, 76.85 ± 9.15 kg, 1.72 ± 0.09 m), with minimum of 12 months of strength training experience, and all participated in the three training methods: the occlusion training (Kaatsu); the tension training (Tension); and the traditional training (Traditional). The Kaatsu training consisted in 3 sets of 10RM with occlusion device in both arms inflated to a 130% occlusion pressure. In addition, the tension method was …

Sources Of Information That Introduced Exercise Science Students To Their Major, Erin Vanderbunt, Doug Brtek

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 3: Issue 1, Article 3, 2022. This study examined the most influential sources of information that first introduced exercise science undergraduate students to their current major and sought to determine if any differences existed between demographic variables. An electronic questionnaire ranking the level of influence of 27 potential sources of information was completed by 131 exercise science students at a regional, midwestern university. Personal experience with the major, health care professionals in the major, and friend or family member in the major were among the highest non-college related sources, while college introductory courses …

Developing A Glossary Of People-Focused Terms Related To Rangelands And Grasslands, Dana Kelly, Katherine I. Johnsen, Chris Magero, Tungalag Ulambayer, Ann Waters-Bayer

IGC Proceedings (1977-2023)

Excellent glossaries on rangelands and grasslands have been developed by the Society for Range Management (SRM), the International Grassland Congress (IGC) and the International Rangeland Congress (IRC). However, these are largely confined to biophysical and technical terminology and contain very few concepts referring to social, institutional and policy aspects of using rangelands and grasslands. After the 10^th IRC in Saskatoon, Canada, in 2016, an informal group started to develop a glossary of such “people-focused” terms. The short and non-academic definitions are meant to improve communication and understanding by users/practitioners in rangeland and grassland management, policymakers, teachers, students, journalists and …

Could Cheese Be The Missing, Hard, Stable Currency To Fortify Self-Sufficiency Of Pastoralist Communities?, D. Schoder, J. Y. Laffa

IGC Proceedings (1977-2023)

Traditional pastoral existence in Africa has always necessitated close, sustainable interaction with a harsh natural environment. Pastoralists, such as the indigenous Parakuyo Maasai of Tanzania traditionally depend on fresh cow’s milk as a staple. They are among the few African ethnic groups that still live as small, socially intact associations close to nature. Unfortunately, fresh milk is difficult to store and inevitably, times of plenty fluctuate with the times of hunger that threaten cultural retreat. Milk storage is particularly challenging in an arid climate without refrigeration and at such times, survival takes precedence over prosperity. We describe an ongoing pilot …

Comparative Analysis Of Cbrm Cases In Kenya, Ethiopia And Tunisia, I. N. Nganga, L. W. Robinson, B. Eba, F. Flintan, E. M. Ontiri, M. Sghaier, N. H. Abdu, S. S. Moiko

IGC Proceedings (1977-2023)

In various countries, development and conservation organizations and national policymakers have been experimenting with ways of applying the community-based natural resource management approach to the unique social and biophysical characteristics of pastoralist rangeland settings, with mixed results. We carried out comparative case study research on community-based rangeland management (CBRM) in a variety of settings in Ethiopia, Kenya and Tunisia with the objective of identifying what kinds of strategies and methods work in which social and ecological contexts. We used an “options by context” approach guided by a research protocol that includes key variables and descriptors for characterizing the implementing organization’s …

Comparative Analysis Of Agri-Food Systems For Extensive Livestock In The High Pyrenees And Creation Of A Multicriterian Tool For Its Evaluation, Laia Motos, Federica Ravera

IGC Proceedings (1977-2023)

The main objective of this study is to compare the different agri-food systems of extensive livestock (ecological and conventional) of big and small ruminants (cattle and sheep respectively) in high Pyrenees. This objective is formulated by looking at the general lack of knowledge of the population regarding the functionality of these systems, the changes of management that have been introduced in the recent years, especially in terms of commercialization, and the different capacity of response of extensive livestock systems to climate change and other socio-economic complementary changes. Attributes and indicators have been selected for the comparative evaluation of livestock systems, …

Analysis Of Rangeland Perceptions Among Potential Land Redistribution Beneficiaries In South Africa: How Well Do Potential Emerging Farmers Know Their Rangelands?, S. Zantsi

IGC Proceedings (1977-2023)

Sound rangeland management is one of the key factors for a successful and viable commercial livestock production in grass fed production systems. However, such knowledge is perceived to be lacking in small-scale livestock farmers, who farm on degraded and overgrazed communal rangelands despite being regarded as prime beneficiaries of the land redistribution programme in the stalling South African land reform. Largely, it is also not known in details how much the potential future commercial farmers know about their rangelands. This study analyses perception of the prime land redistribution beneficiaries—potential emerging farmers, who were surveyed randomly in three South African provinces. …

Development Of Effectual Substrates For Sers By Nanostructurs-Coated Porous Silicon, Fatima J. Moaen, Hammad R. Humud, Fouad G. Hamzah

Karbala International Journal of Modern Science

The current paper provides an efficient method for making active and effectual substrates used for detecting molecules by improving surface-enhanced Raman scattering (SERS). These substrates were fabricated using nanostructure-coated porous silicon. The nanostructures were prepared through the electrical exploding wire (EEW) technique. The silver nanowires (AgNWs) were coated with a polydopamine (PDA) layer to form an AgNWs@PDA colloidal solution. Then, the Ag wire was electrically exploded in the colloidal solution to form the (AgNWs@PDA@AgNPs) plasmonic nanostructures as a metal-insulator-metal. The effect of the plasmonic nanostructures’ morphologies on the absorptances spectra and SERS activities were studied utilising Rhodamine 6G (Rh6G) dye …

Preparation And Characteristics Study Of Porous Silicon For Vacuum Sensor Application, Noor S. Dawood, Mehdi Q. Zayer, Muslim F. Jawad

Karbala International Journal of Modern Science

Vacuum is a technique that can be employed to measure pressures less than atmosphere (101325 mbar), the vacuum is too important in numerous fields of life. In the present research, the sensor of vacuum has been produced using a porous layer of silicon (Psi). N-type of silicon wafer (Si) has been used for formulating Psi samples utilizing photo-electrochemical etching (PECE) technique. The experimental work was carried out under different etching times (30, 60, and 90 min) while fixing the other parameters, including (24%) Hydrofluoric (HF) acid and (20 mA/cm²) current density. The pore width and depth and porosity …

Possible Association Of Telomere Length With Sleep Duration. A Preliminary Pilot Study In A Sicilian Cohort With Centenarians., Anna Aiello, Giulia Accardi, Sawan Alì, Calogero Caruso, Maxine Chen, Immaculata De Vivo, Mattia Emanuela Ligotti, Giovanni Scapagnini, Sergio Davinelli, Giuseppina Candore

Translational Medicine @ UniSa

Telomere length (TL) is considered a biomarker of ageing although this topic is still debated. Also, sleep pattern changes are physiological part of the normal ageing process. In fact, it is widely recognized that sleep duration declines with age, leading to dysregulation of circadian rhythms. The aim of our study was to analyse the possible association of sleep duration with TL in a sample of 135 subjects with ages ranging from 20 to 111 years, recruited from Palermo and neighbouring municipalities in Sicily (Italy). Preliminary data suggest that relative TL (RTL) decreases with age in both men and women. However, …

Epigallocatechin-3-Gallate (Egcg): New Therapeutic Perspectives For Neuroprotection, Aging, And Neuroinflammation For The Modern Age, Ashley Payne, Samuel N. Nahashon, Equar Taka, Getinet M. Adinew, Karam F. A. Soliman

Agricultural and Environmental Sciences Faculty Research

Alzheimer's and Parkinson’s diseases are the two most common forms of neurodegenerative diseases. The exact etiology of these disorders is not well known; however, environmental, molecular, and genetic influences play a major role in the pathogenesis of these diseases. Using Alzheimer’s disease (AD) as the archetype, the pathological findings include the aggregation of Amyloid Beta (Aβ) peptides, mitochondrial dysfunction, synaptic degradation caused by inflammation, elevated reactive oxygen species (ROS), and cerebrovascular dysregulation. This review highlights the neuroinflammatory and neuroprotective role of epigallocatechin-3-gallate (EGCG): the medicinal component of green tea, a known nutraceutical that has shown promise in modulating AD progression …

Descripción De Una Nueva Especie De Tegmaleurodes Martin (Hemiptera: Aleyrodidae) De Guatemala, José Francisco García-Ochaeta

Insecta Mundi

Se describe Tegmaleurodes sanchezi, nueva especie (Hemiptera: Aleyrodidae), de Guatemala. Se proporcionan microfotografías de estructuras morfológicas del pupario, se comentan las características dife­renciales de la especie con sus congéneres y se incluye una clave para las especies.

Tegmaleurodes sanchezi, new species (Hemiptera: Aleyrodidae), is described from Guatemala. Photomicrographs of the morphological structures of the puparium are provided, distinguishing characteris­tics of the species from its congeners are discussed, and a key to the species is included.

El género de moscas blancas Tegmaleurodes fue descrito por Martin (2005), incluyendo las tres especies neotro­picales Tegmaleurodes lentus Martin, 2005, T. crustatus (Bondar, …

Taxonomic Changes Suggested By The Genomic Analysis Of Hesperiidae (Lepidoptera), Jing Zhang, Qian Cong, Jinhui Shen, Nick V. Grishin

Insecta Mundi

Our expanded efforts in genomic sequencing to cover additional skipper butterfly (Lepidoptera: Hesperiidae) species and populations, including primary type specimens, call for taxonomic changes to re­store monophyly and correct misidentifications by moving taxa between genera and proposing new names. Reconciliation between phenotypic characters and genomic trees suggests three new tribes, two new sub­tribes, 23 new genera, 17 new subgenera and 10 new species that are proposed here: Psolosini Grishin, new tribe (type genus Psolos Staudinger, 1889), Ismini Grishin, new tribe (type genus Isma Distant, 1886), Eetio­nini Grishin, new tribe (type genus Eetion de Nicéville, 1895), Orphina Grishin, new subtribe (type …

Longitudinal Association Of Biological Maturation With Physical Activity Behaviors In Girls Transitioning From 5th To 7th Grade, Russell R. Pate, Marsha Dowda Ph.D., Rod L. Dishman, Joseph Gorab, Agnes Bucko, Ruth P. Saunders Ph.D.

Faculty Publications

Introduction

This longitudinal study determined if social cognitive variables influence physical activity in girls stratified on the basis of maturity status.

Methods

Participants attended South Carolina public schools (Mage in 5th grade = 11.1 years) and included a cohort of 529 girls who provided physical activity data in the 5th grade and in 6th and/or 7th grade. The measure of maturity status was age at peak height velocity (APHV) estimated from maturity offset when the children were in the 5th grade. The Earlier Maturity (EM) group included girls whose APHV was one standard deviation or more below the mean APHV …

Enhancing The Bioaccessibility Of Lycopene From Tomato Processing Byproducts Via Supercritical Carbon Dioxide Extraction, Ali Ubeyitogullari, Ozan N. Ciftci

Department of Food Science and Technology: Faculty Publications

Tomato peel and seed from tomato processing industry are treated as waste; however, they contain lycopene, a high-value bioactive compound. In this study, lycopene was extracted from tomato peel and seed using supercritical carbon dioxide (SC–CO₂) and hexane, and the bioaccessibilities of lycopene in the SC-CO₂- and hexaneextracted oleoresins were investigated for the first time. The (Z)-lycopene content of the SC-CO₂-extracted oleoresin (69%) was higher than that of hexane-extracted oleoresin (45%). Separation of the insoluble fraction from the oleoresins increased the (Z)-lycopene contents of the SC-CO₂- and hexane-extracted oil fractions to 80% …

Case Report: Pharmacogenetics Applied To Precision Psychiatry Could Explain The Outcome Of A Patient With A New Cyp2d6 Genotype, Elena Marcos-Vadillo, Lorena Carrascal-Laso, Ignacio Ramos-Gallego, Andrea Gaedigk, Belén García-Berrocal, Eduardo Mayor-Toranzo, Alfonso Sevillano-Jiménez, Almudena Sánchez, María Isidoro-García, Manuel Franco-Martín

Manuscripts, Articles, Book Chapters and Other Papers

Precision medicine applied to psychiatry provides new insight into the promising field of precision psychiatry. Psychotic disorders are heterogeneous, complex, chronic, and severe mental disorders. Not only does the prognosis and the course of the disease vary among patients suffering from psychotic disorders, but the treatment response varies as well. Although antipsychotic drugs are the cornerstone of the treatment of schizophrenia, many patients only partially respond to these drugs. Furthermore, patients often experience adverse events which can lead to poor treatment adherence. Interindividual variability in drug response could be related to age, gender, ethnicity, lifestyle factors, pharmacological interactions, obesity, and …

Carbapenemase-Producing Pseudomonas Aeruginosa – An Emerging Challenge, Fred C. Tenover, David P. Nicolau, Christian M. Gill

Biology Faculty Publications

Carbapenem-resistant Pseudomonas aeruginosa (CR-PA) is a major healthcare-associated pathogen worldwide. In the United States, 10–30% of P. aeruginosa isolates are carbapenem-resistant, while globally the percentage varies considerably. A subset of carbapenem-resistant P. aeruginosa isolates harbour carbapenemases, although due in part to limited screening for these enzymes in clinical laboratories, the actual percentage is unknown. Carbapenemase-mediated carbapenem resistance in P. aeruginosa is a significant concern as it greatly limits the choice of anti-infective strategies, although detecting carbapenemase-producing P. aeruginosa in the clinical laboratory can be challenging. Such organisms also have been associated with nosocomial spread requiring infection prevention interventions. The carbapenemases …

An Analysis Of Community-Based Values Informing Land Management On The Midwestern Prairie Band Potawatomi Nation Of Kansas, Usa, Heidi Mehl, Diana L. Restrepo-Osorio, Melinda Howard, Cynthia Annett

IGC Proceedings (1977-2023)

The focus of this study is to examine the interface between land management practices and values within a tribal community in rural midwestern North America. The Prairie Band Potawatomi Nation (PBPN) reside on a tribal reservation with a checkerboard distribution amongst private, non-tribal landowners. Previous studies have indicated that landowners may have different value-systems leading to variations in land-management practices. This can impose discontinuous land management in areas within shared biological boundaries, such as watersheds, especially between tribal and non-tribal entities. Preliminary spatial analysis in and around the PBPN landscape determined that the tribally-managed lands present more vegetative cover per …

A Policy Brief On Adopting The Somali Camel For Enhanced Profitability And Pastoral Resilience In Northern Kenya, Simon G. Kuria, A. O. Adongo, S. Murithi, O. K. Koech, J. T. Njoka, P. Kamande

IGC Proceedings (1977-2023)

Persistent drought and high temperatures in Isiolo and Marsabit counties of northern Kenya repeatedly devastate livestock herds particularly cattle making the pastoralists less resilient, more vulnerable to climate change and poor. To address this challenge, an IGAD funded project promoted adoption of Somali camel breed, trained farmers on improved management and also estimated potential profitability of rearing the camel. Through the project, trainers were trained and facilitated to train 240 peri-urban Somali camel producers in Isiolo and Marsabit on breeding, health, routine husbandry and marketing. Impact study documenting positive stories of change was conducted at the end. Producers who hitherto …

Red Clover Improves The Energy To Protein Balance Of Lucerne-Grass Herbage, X. Godin, Gaëtan F. Tremblay, P. Seguin, S. Bittman, D. Hunt, J. Hakl, G. Bélanger, M.-N. Thivierge, A. Bertrand, M. Thériault, A. Claessens

IGC Proceedings (1977-2023)

Low ratio of readily fermentable carbohydrate to soluble protein concentrations in lucerne (Medicago sativa L.) leads to inefficient use of herbage N by ruminants. To improve the energy to protein balance in lucerne-grass herbage, four proportions of lucerne:red clover (Trifolium pratense L.) were compared in mixtures with and without grasses: timothy (Phleum pratense L.) and tall fescue (Schedonorus arundinaceus Schreb. Dumort.) in Quebec (QC, Canada). In the first post-seeding year, red clover proportion averaged (across grasses and four harvests) 0, 37, 59, and 74% in herbage mixtures. Increasing the proportion of red clover caused a slight …