Life Sciences Commons^™

Volume 2, Chapter 19-2: Bryophyte Bacteria Effects On Communities, Janice M. Glime

Bryophyte Ecology Subchapters

No abstract provided.

High-Frequency Accelerometer Recording Of Key Predatory Behaviors In Vipers: Validation And Case Study With Timber Rattlesnakes (Crotalus Horridus), Morgan L. Thompson, Richard H. Adams, Anna Tipton, Dominic L. Desantis

Graduate Research Showcase

High-frequency accelerometer recording of key predatory behaviors in vipers: validation and case study with Timber Rattlesnakes (Crotalus horridus)

Morgan Thompson, Richard H. Adams, Anna F. Tipton, and Dominic L. DeSantis

Tri-axial accelerometers (ACTs) are becoming increasingly common in studies of animal behavior wherein direct observation of subjects in nature is constrained or impossible. ACTs are small (< 1 g) piezo-electric (spring-like) sensors that measure three-dimensional acceleration (upward, downward, and side-to-side) derived from subject motion. When leveraged with advanced machine learning techniques, these data can enable precise automated classification of a wide range of movement-mediated behaviors. Until recently, ACTs were largely reserved for larger-bodied organisms or those most amenable to the temporary external attachment of devices. Ongoing ACT miniaturization has now expanded the breadth of organisms amenable to these methods. This project aims to expand on a recently developed framework for ACT monitoring in wild-ranging snakes, a group that has been mostly overlooked in biologging applications. We are currently conducting extensive captive validation trials for robust model training and testing to enable classification of predatory behaviors, including striking and ingestion of prey items, in Timber Rattlesnakes (Crotalus horridus). Following captive validation, we will translate this method to the field with a population of C. horridus in the lower Piedmont of middle Georgia to evaluate the efficacy of externally attached ACTs for remote and continuous monitoring of …

Physicochemical And Pasting Properties Of Flour And Starch From Two New Cassava Accessions, Raphael Aidoo, Ibok Nsa Oduro, Jacob K. Agbenorhevi, William Otoo Ellis, Nana Baah Pepra-Ameyaw

Food Science Faculty Articles and Research

Some new cassava accessions have been developed and released because of their high yield, resistance to disease, adaptability to wider ecological environment, and less cost of production. However, their flour and starch properties have not been characterized for potential food applications. In the present study, starch and flour were produced from two new cassava accessions (Sika Bankye and Bankye Hemaa) and evaluated for their physicochemical and pasting properties. The flour samples recorded higher values for the various functional parameters compared to their starch counterparts. Both flour samples had a similar water absorption capacity (WAC) of ~263% but the associated …

Phenotypic Variability In Ipsc-Induced Cardiomyocytes And Cardiac Fibroblasts Carrying Diverse Lmna Mutations, Jiajia Yang

USF Tampa Graduate Theses and Dissertations

Mutations in the LMNA gene (encoding lamin A/C) are the second most common cause of familial arrhythmogenic cardiomyopathy. Diverse LMNA variants in cardiomyocytes have been associated with cardiac phenotypes. Moreover, cardiac fibroblasts make up a large fraction of the myocardium's non-myocyte component, intrinsically linked to extracellular matrix synthesis and turnover as well as secreting large amounts of bioactive metabolites. However, our understanding of how different mutation sites and the non-myocyte niche mediate cardiomyocyte function is limited. To fill this gap, in this thesis I investigated the hypothesis that variable LMNA mutations have significant effects on the genetic, structure and electrophysiological …

A Global Soil Spectral Calibration Library And Estimation Service, Keith D. Sheperd, Rich Ferguson, David Hoover, Fenny Van Egmond, Jonathan Sanderman, Yufeng Ge

Department of Agronomy and Horticulture: Faculty Publications

There is growing global interest in the potential for soil reflectance spectroscopy to fill an urgent need for more data on soil properties for improved decision-making on soil security at local to global scales. This is driven by the capability of soil spectroscopy to estimate a wide range of soil properties from a rapid, inexpensive, and highly reproducible measurement using only light. However, several obstacles are preventing wider adoption of soil spectroscopy. The biggest obstacles are the large variation in the soil analytical methods and operating procedures used in different laboratories, poor reproducibility of analyses within and amongst laboratories and …

Differences In Stronger Versus Weaker Firefighters In Selected Measures Of Power, Quincy Johnson, J. Jay Dawes, Melissa Uftring, Marcel Lopes Dos Santos, Davis Hale, Gabriel J. Sanders, Will Peveler, Roger O. Kollock

International Journal of Exercise Science

International Journal of Exercise Science 15(4): 552-560, 2022. Firefighters are required to perform a wide array of physically demanding job tasks, such as forcible entry, charged hose advances and victim extractions. An adequate level of muscular strength and power are required to successfully perform these tasks. The purpose of this study is to investigate the differences in stronger and weaker firefighters in measures of power. Archived data for twenty-seven (age = 34.3 ± 7.9 yr, body height = 176.3 ± 7.2 cm, body mass = 89.4 ± 15.7 kg) full-time firefighters were analyzed. Participants were placed into one of two …

Effects Of Six-Week Periodized Versus Non-Periodized Kettlebell Swing Training On Strength, Power And Muscular Endurance, Evaldo Rui Tavares Santos Junior, Belmiro De Salles, Ingrid Dias, Roberto Simão, Jeff Willardson

International Journal of Exercise Science

International Journal of Exercise Science 15(4): 526-540, 2022. The purpose of this study was to compare a periodized versus a non- periodized protocol of kettlebell (KTB) swings over six weeks on strength, power, and muscular endurance. Twenty-eight high intensity functional training (HIFT) practitioners were assigned to non- periodized (NPG = 11), periodized (PG = 11), or control groups (CG = 6). NPG used the same load (20 kg) throughout the training period while the PG used a step loading progression (with an added four kilograms every two weeks). Measures of strength and muscular endurance in the deadlift exercise, and power …

Effect Of Different Numbers Of Interset Antagonist Proprioceptive Neuromuscular Facilitation Stretching On The Total Number Of Repetitions For The Agonists, Humberto Miranda, Aline Aparecida De Oliveira, Juliana Soares Dos Santos Ribeiro, Fabio Henrique De Freitas, Juliana Brandão Pinto De Castro, Renato L. Alvarenga, Jeff Willardson

International Journal of Exercise Science

International Journal of Exercise Science 15(4): 498-506, 2022. Recent studies have observed that stretching applied to antagonist muscles can promote improvement in agonist muscle performance. The purpose of this study was to investigate the effect of different numbers of interset proprioceptive neuromuscular facilitation (PNF) stretching for the antagonists on the total number of repetitions completed for the agonists (quadriceps) in the leg extension exercise. Fourteen physically active individuals (age: 29.35 ± 10.5 years; body mass: 79.1 ± 11.34 kg; height: 170.4 ± 8.7 cm) participated in this study. The following experimental protocols were performed: 1) Traditional protocol (Traditional) …

Pre-Exhaustion Training, A Narrative Review Of The Acute Responses And Chronic Adaptations, Thiago Trindade, Ragami Alves, Bruno De Castro, Matheus De Medeiros, Jason De Medeiros, Paulo Dantas, Jonato Prestes

International Journal of Exercise Science

International Journal of Exercise Science 15(3): 507-525, 2022. Pre-exhaustion (PE) is a popular resistance training strategy that involves performing a single-joint exercise followed by a multi-joint exercise with minimal recovery between the transition. This approach is widely used by bodybuilding athletes and resistance training (RT) enthusiasts with the aim of enhancing muscle strength and hypertrophy. The present paper aimed to provide a narrative review as to the effects of the PE method on different acute and chronic outcomes, and discuss relevant practical applications. When considering the body of literature as a whole, we conclude that current evidence does not support …

Electromyographic Examination Of Hip And Knee Extension Hex Bar Exercises Varied By Starting Knee And Torso Angles, Edward Jo, Kevin A. Valenzuela, Whitney Leyva, Jennifer Rivera, Kalin Tomlinson, Elisabeth Zetiz

International Journal of Exercise Science

International Journal of Exercise Science 15(1): 541-551, 2022. Variations of the deadlift can be executed using the hexagonal (hex) bar by altering, for instance, the knee and torso angles while maintaining a constant hip angle at the start position. PURPOSE: To examine muscle activation patterns of the biceps femoris, rectus femoris, and erector spinae during three deadlift variations using the hex bar. METHODS: Twenty resistance-trained male and female subjects performed hex bar deadlift variations in three different starting knee flexion positions: 128.4 ± 8.5°, 111.9 ± 8.7°, and 98.3 ± 6.5°. Subjects performed three repetitions at 75% of their three-repetition …

Case 71: Lactate Dehydrogenase As A Therapeutic Target To Treat Parasitic Disease, Dr. Kathleen Cornely

Chemistry & Biochemistry Case Studies

In this case study, researchers use their knowledge of lactate dehydrogenase in parasites and humans to investigate inhibitors that are selective for the parasite agent.

Comparative Toxicity Of Hydrocarbons For Evaluation Of Lysmata Boggessi As An Experimental Proxy For Deep-Water Column Micronekton, Dorothy-Ellen A. Renegar, Nicholas Turner, Gopal Bera, Eileen G. Whitemiller, Bernhard Riegl, Jose Sericano, Anthony H. Knap

Marine & Environmental Sciences Faculty Articles

The potential impacts of sub-surface hydrocarbon plumes to deep-water column micronekton are an important consideration in a more complete understanding of ecosystem effects resulting from deep-sea oil spills. However, evaluating toxicity in these organisms presents multiple challenges, and the use of a shallow-water proxy species allows comparison and validation of experimental results. This study thus examined the suitability of the peppermint shrimp, Lysmata boggessi, as an experimental proxy for ecologically important deep-sea zooplankton/micronekton in hydrocarbon toxicity assays. This crustacean species occurs in shallow coastal marine environments throughout the western Atlantic, Caribbean and Gulf of Mexico, is similar in …

Anti-Tumor Activity Of Cetuximab Plus Avelumab In Non-Small Cell Lung Cancer Patients Involves Innate Immunity Activation: Findings From The Cave-Lung Trial, Carminia Maria Della Corte, Morena Fasano, Vincenza Ciaramella, Flora Cimmino, Robert Cardnell, Carl M Gay, Kavya Ramkumar, Lixia Diao, Raimondo Di Liello, Giuseppe Viscardi, Vincenzo Famiglietti, Davide Ciardiello, Giulia Martini, Stefania Napolitano, Concetta Tuccillo, Teresa Troiani, Erika Martinelli, Jing Wang, Lauren Byers, Floriana Morgillo, Fortunato Ciardiello

Faculty, Staff and Student Publications

BACKGROUND: We recently conducted Cetuximab-AVElumab-Lung (CAVE-Lung), a proof-of-concept, translational and clinical trial, to evaluate the combination of two IgG1 monoclonal antibodies (mAb): avelumab, an anti-PD-L1 drug, and cetuximab, an anti-epidermal growth factor receptor (EGFR) drug, as second- or third-line treatment in non-small cell lung cancer (NSCLC) patients. We have reported clinically relevant anti-tumor activity in 6/16 patients. Clinical benefit was accompanied by Natural Killer (NK) cell-mediated antibody-dependent cell cytotoxicity (ADCC). Among the 6 responding patients, 3 had progressed after initial response to a previous treatment with single agent anti-PD-1, nivolumab or pembrolizumab.

METHODS: We report long-term clinical follow-up and additional …

Human Adaptation And Morphological Variation: Expanding Diversity In Anatomy Curriculum, Jordan Cass, Cooker Storm

Seaver College Research And Scholarly Achievement Symposium

Introduction: The recent upturn in our nation’s socio-political conversation has fueled interest in ensuring that college curricula is diverse and inclusive. Because human anatomy is ubiquitous across colleges, it may be a valuable avenue to purposefully incorporate topics of diversity in a way that positively impacts our socio-cultural relationships. Providing students with a scientific understanding of our visible differences may mitigate subconscious bias when we see others who have different features. Purpose: We investigated the biogeographical factors that contribute to the morphological variability of the face, hair, and body size; with the secondary aim of developing diverse and …

Developmental Staging And Morphological Comparisons Of Four Fern Gametophyte Species From The Santa Monica Mountains, Tristan Furlong

Seaver College Research And Scholarly Achievement Symposium

The fern life cycle alternates between two distinct phases: a diploid sporophyte phase consisting of the “adult” fern, and a haploid gametophyte phase. Early events and changes in gametophyte development can have considerable consequences in the morphologies of these different fern species and may facilitate the various adaptive strategies employed by the gametophytes in their different habitats. This study investigates early developmental events in the gametophytes of four different fern species found in the Santa Monica Mountains, Adiantum jordanii (chaparral understory, summer deciduous sporophyte), Woodwardia fimbriata (riparian stream), Dryopteris arguta (chaparral understory, evergreen), and Pentagramma triangularis (chaparral understory, resurrection sporophyte). …

Substrate Type Affects The Drying Speed And Desiccation Tolerance Of Fern Gametophytes, Jordyn D. Regier, Mayra J. Hernandez, Camille K. Sicangco, Stephen D. Davis, Helen I. Holmlund

Seaver College Research And Scholarly Achievement Symposium

Although most ferns require abundant water to thrive, some ferns can survive in habitats with limited water. Previous studies have examined the adaptations that allow xeric ferns to thrive in mediterranean-type ecosystems such as southern California. However, the large fern sporophyte only represents one stage of the fern life cycle; the independent gametophyte phase must also survive water stress, including the six-month summer drought periods of the Santa Monica Mountains. Some fern gametophytes have been reported to be desiccation tolerant (capable of recovery from near-complete drying), and this trait is believed to be dependent on the plant’s drying speed. In …

Endogenous Cftr Expression In Human Epithelial Cell Lines, Zithlaly Amezquita

Undergraduate Research Conference

CFTR (Cystic Fibrosis Transmembrane-conductance Regulator) is a plasma membrane protein that functions as a chloride ion channel on many epithelial cells. There are over 1000 mutations that affect the function of this protein; however, the most common mutation is DF508. CFTR mutations target many secretory organs like pancreas and lungs causing the genetic disease cystic fibrosis (CF), common among Caucasians of northern European origin. Detection of endogenous CFTR expression is possible by a difficult and costly immunoprecipitation method but not by the most used western blotting method. Therefore, the goal of this project was to detect the endogenous CFTR expression …

Absence Of Streptococcus Pneumoniae Capsule Increases Bacterial Binding, Perisstence, And Inflammation In Corneal Infection, Mary A. Carr, Dennis Marcelo, K. Michael Lovell, Angela H. Benton, Nathan A. Tullos, Erin W. Norcross, Brandon Myers, Hayley Craddieth, Mary E. Marquart

Student Publications

The role of the pneumococcal polysaccharide capsule is largely unclear for Streptococcus pneumoniae keratitis, an ocular inflammatory disease that develops as a result of bacterial infection of the cornea. In this study, capsule-deficient strains were compared to isogenic parent strains in their ability to adhere to human corneal epithelial cells. One isogenic pair was further used in topical ocular infection of mice to assess the contribution of the capsule to keratitis. The results showed that non-encapsulated pneumococci were significantly more adherent to cells, persisted in significantly higher numbers on mouse corneas in vivo, and caused significant increases in murine ocular …

Nitrogen Increases Early-Stage And Slows Late-Stage Decomposition Across Diverse Grasslands, Allison L. Gill, Peter B. Adler, Elizabeth T. Borer, Christopher R. Buyarski, Elsa E. Cleland, Carla M. D'Antonio, Kendi F. Davies, Daniel S. Gruner, W. Stanley Harpole, Kirsten S. Hofmockel, Andrew S. Macdougall, Rebecca L. Mcculley, Brett A. Melbourne, Joslin L. Moore, John W. Morgan, Anita C. Risch, Martin Schütz, Eric W. Seabloom, Justin P. Wright, Louie H. Yang, Sarah E. Hobbie

Wildland Resources Faculty Publications

1. To evaluate how increased anthropogenic nutrient inputs alter carbon cycling in grasslands, we conducted a litter decomposition study across 20 temperate grasslands on three continents within the Nutrient Network, a globally distributed nutrient enrichment experiment
2. We determined the effects of addition of experimental nitrogen (N), phosphorus (P) and potassium plus micronutrient (K_μ) on decomposition of a common tree leaf litter in a long-term study (maximum of 7 years; exact deployment period varied across sites). The use of higher order decomposition models allowed us to distinguish between the effects of nutrients on early- versus late-stage decomposition.
3. Across continents, the …

Size Structure And Intraguild Interactions Between Two Ambystoma Species, Gwyneth Daunton

Theses and Dissertations

Intraguild interactions affect population and community structure through a combination of competition and predation. Changes in size structure influence intraguild interactions by affecting the strength and direction of these species’ interactions. I tested for size-structured intraguild interactions in temporary pond ecosystems between marbled salamanders (Ambystoma opacum) and tiger salamanders (Ambystoma tigrinum) using an outdoor mesocosm experiment. I hypothesized that 1) A. opacum survivorship and growth would be negatively impacted when both species start at a similar size because tiger salamanders grow faster and are more aggressive 2) A. tigrinum will grow slower and have lower survivorship …

Analyzing Inhibitors Of The Sars-Cov-2 Endoribonuclease Nsp15, Mary Staunton

Honors Scholar Theses

The global pandemic caused by the virus SARS-CoV-2 has devastated the world. A flurry of research into the structures and activities of the virus have identified several viable targets for drug therapy, including the endoribonuclease nsp15, also known as EndoU. EndoU has been shown to play a role in diminishing the host cell’s immune response to the virus by cleaving signaling dsRNA, specifically targeting uridine sequences. The development of the crystal structure nsp15 allowed our lab along with others to perform virtual screenings to identify inhibitors that might be able to dock at the active site and inhibit the activity …

The Design, Construction, And Testing Of A Recombinant Dna Vaccine For Brucella Abortus And Brucella Melitensis, Stephanie Lynn Korle

LSU Doctoral Dissertations

Brucella spp. are a bacterium that cause brucellosis, a zoonotic disease, which is commonly seen in cattle, sheep, goats, swine, and canines. Brucellosis is a problem worldwide, although it is eradicated in some countries (Garin-Bastuji et al. 1998). The reason for designing recombinant DNA (rDNA) vaccines opposed to utilizing the live-attenuated vaccines on the market is that they cannot be given to pregnant animals without potentially causing abortion, while an rDNA vaccine should be safe for pregnant animals since it does not contain viable bacteria. Also, there are no serological tests that can accurately distinguish between an animal vaccinated …

Plant-Soil Feedbacks Help Explain Plant Community Productivity, Andrew Kulmatiski, Jeanette Norton, Leslie E. Forero, Josephine Grenzer

Browse all Datasets

Plant community productivity tends to increase as species richness increases, but the mechanisms behind this biodiversity-productivity relationship are not fully understood. Plant-soil feedbacks (PSF) are a compelling potential mechanism of the biodiversity-productivity relationship because they can explain patterns of both underyielding and overyielding in diverse plant communities. To test the role of plant-soil feedbacks in the biodiversity-productivity relationship we measured all possible plant-soil feedbacks for sixteen species, and used the measured plant-soil feedbacks to predict plant community biomass production. We compared the predicted plant community biomass production to observed biomass production in a paired biodiversity-productivity experiment.

Transcriptomic Analysis Of Liver Indicates Novel Vaccine To Porcine Reproductive And Respiratory Virus Promotes Homeostasis In T-Cell And Inflammatory Immune Responses Compared To A Commercial Vaccine In Pigs, Damarius S. Fleming, Laura C. Miller, Jiuyi Li, Albert Van Geelen, Yongming Sang

Agricultural and Environmental Sciences Faculty Research

One of the largest impediments for commercial swine production is the presence of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), a devastating RNA viral infection that is responsible for over $1 billion in loss in the U.S. annually. The challenge with combating PRRSV is a combination of the effect of an extraordinary rate of mutation, the ability to infect macrophages, and subversion of host immune response through a series of actions leading to both immunomodulation and immune evasion. Currently there are a handful of commercial vaccines on the market that have been shown to be effective against homologous infections, but …

Comparison Of Recent Survey Techniques For Estimating Benthic Cover On Caribbean Mesophotic Reefs, Joseph R. Pawlik, Roy A. Armstrong, Stephanie Farrington, John Reed, Sara Rivero-Calle, Hanumant Singh, Brian K. Walker, Jason White

Marine & Environmental Sciences Faculty Articles

Highly divergent estimates of benthic cover of sponges have been reported for Caribbean mesophotic reefs (90-100 m) based on quadrat point-intercept data collection using 2 methods: visual surveys conducted in situ by technical divers, and analyses of photographs taken by unmanned underwater vehicles (UUVs). The second method has been criticized for potential errors from image distortion caused by variable camera angle relative to the substratum, but without a broader comparison of both methods. We find that studies that have used the UUV-based method are advantageous for a number of reasons, most importantly: (1) access to the full mesophotic zone, (2) …

Rethinking Public Health Risk Mitigation Strategies: Recognizing The Biosocial Nature Of Covid-19, Grace Savard

CSB and SJU Distinguished Thesis

The SARS-CoV-2 virus has rippled throughout every aspect of society and influenced how we live, breathe, and interact with one another. The purpose of this thesis is to explore the interdisciplinary biosocial impacts of the SARS-CoV-2 virus and the resulting disease, COVID-19. In order to understand the complexities of caregiving during COVID-19, we conducted 75 semi-structured interviews with 55 healthcare providers across 18 states over a span of two years. This research assesses how COVID-19 risk mitigation strategies were designed with the primary intention to stop the spread of the virus rather than account for the longer-term social and biological …

Statistical Modeling Of Drug Properties, Host Clinical And Genetic Factors In Drug-Induced Liver Injury, Kristin Ashby

Theses and Dissertations

Drug-induced liver injury (DILI) is a rare adverse reaction that can result in liver transplant or death. Currently, there are no reliable methods to identify which individuals are at risk of developing severe or chronic DILI prior to drug administration. Here, we investigated the interplay between drug properties, clinical, and genetic factors and DILI risk, severity, and trajectory. First, we used a large, published dataset of 1036 drugs to examine the relationship between DILI risk and two drug properties, lipophilicity and extent of metabolism. Each drug property was tested alone and in combination with daily dose using five different DILI …

An Objective System For Quantitative Assessment Of Television Viewing Among Children (Family Level Assessment Of Screen Use In The Home-Television): System Development Study, Anil Kumar Vadathya, Salma Musaad, Alicia Beltran, Oriana Perez, Leo Meister, Tom Baranowski, Sheryl O Hughes, Jason A Mendoza, Ashutosh Sabharwal, Ashok Veeraraghavan, Teresia O'Connor

Children’s Nutrition Research Center Staff Publications

Background: Television viewing among children is associated with developmental and health outcomes, yet measurement techniques for television viewing are prone to errors, biases, or both.

Objective: This study aims to develop a system to objectively and passively measure children's television viewing time.

Methods: The Family Level Assessment of Screen Use in the Home-Television (FLASH-TV) system includes three sequential algorithms applied to video data collected in front of a television screen: face detection, face verification, and gaze estimation. A total of 21 families of diverse race and ethnicity were enrolled in 1 of 4 design studies to train the algorithms and …

Using Quantitative Imaging For Personalized Medicine In Pancreatic Cancer: A Review Of Radiomics And Deep Learning Applications, Kiersten Preuss, Nate Thach, Xiaoying Liang, Michael Baine, Justin Chen, Chi Zhang, Huijing Du, Hongfeng Yu, Chi Lin, Michael A. Hollingsworth, Dandan Zheng

School of Biological Sciences: Faculty Publications

As the most lethal major cancer, pancreatic cancer is a global healthcare challenge. Personalized medicine utilizing cutting-edge multi-omics data holds potential for major breakthroughs in tackling this critical problem. Radiomics and deep learning, two trendy quantitative imaging methods that take advantage of data science and modern medical imaging, have shown increasing promise in advancing the precision management of pancreatic cancer via diagnosing of precursor diseases, early detection, accurate diagnosis, and treatment personalization and optimization. Radiomics employs manually-crafted features, while deep learning applies computer-generated automatic features. These two methods aim to mine hidden information in medical images that is missed by …

Blinatumomab Maintenance After Allogeneic Hematopoietic Cell Transplantation For B-Lineage Acute Lymphoblastic Leukemia, Mahmoud R Gaballa, Pinaki Banerjee, Denái R Milton, Xianli Jiang, Christina Ganesh, Sajad Khazal, Vandana Nandivada, Sanjida Islam, Mecit Kaplan, May Daher, Rafet Basar, Amin Alousi, Rohtesh Mehta, Gheath Alatrash, Issa Khouri, Betul Oran, David Marin, Uday Popat, Amanda Olson, Priti Tewari, Nitin Jain, Elias Jabbour, Farhad Ravandi, Hagop Kantarjian, Ken Chen, Richard Champlin, Elizabeth Shpall, Katayoun Rezvani, Partow Kebriaei

Faculty, Staff and Student Publications

Patients with B-lineage acute lymphoblastic leukemia (ALL) are at high-risk for relapse after allogeneic hematopoietic cell transplantation (HCT). We conducted a single-center phase 2 study evaluating the feasibility of 4 cycles of blinatumomab administered every 3 months during the first year after HCT in an effort to mitigate relapse in high-risk ALL patients. Twenty-one of 23 enrolled patients received at least 1 cycle of blinatumomab and were included in the analysis. The median time from HCT to the first cycle of blinatumomab was 78 days (range, 44 to 105). Twelve patients (57%) completed all 4 treatment cycles. Neutropenia was the …