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Articles 53491 - 53520 of 254175

Full-Text Articles in Life Sciences

Sustainable Intensification In Crop-Livestock Systems, P. Rovira, Paulo C. De F. Carvalho, J. Terra, F. Lattanzi, R. Pizzio, W. Ayala Mar 2022

Sustainable Intensification In Crop-Livestock Systems, P. Rovira, Paulo C. De F. Carvalho, J. Terra, F. Lattanzi, R. Pizzio, W. Ayala

IGC Proceedings (1977-2023)

Extensive livestock production is the main animal source food system in the Pampas and Campos sub-regions in South America. Beef cattle and sheep convert forage biomass that humans cannot eat into nutrient-dense human-edible foods (meat and milk) and valuable co-products (wool). However, diverse global pressures are acting on Pampas systems including increasing demand for protein sources (food security), climate change, environmental footprint, and competition for land. The integration of small areas of pasture-crop rotations is an alternative for increasing efficiency and sustainable intensification of agroecosystems based on natural grasslands. Rotations led by improved pastures increase the carrying capacity and productivity …


Nutritional Sensitivity Per Morphological Component In Urochloa Hybrid Under Tropical Environments, Bernal-Flores Alvaro, E. A. Pizarro, Adrián R. Quero-Carrillo, Paulino Pérez-Rodríguez, Ramon Rodolfo Ruíz, Thiago Da Cruz Madeira Mar 2022

Nutritional Sensitivity Per Morphological Component In Urochloa Hybrid Under Tropical Environments, Bernal-Flores Alvaro, E. A. Pizarro, Adrián R. Quero-Carrillo, Paulino Pérez-Rodríguez, Ramon Rodolfo Ruíz, Thiago Da Cruz Madeira

IGC Proceedings (1977-2023)

Camello® (GP 3025) is a tolerant to drought Urochloa hybrid grass showing good forage production, early flowering with high regrowth rates. The objective was to define nutrient concentration changes by morphological component and, their differences for two tropical contrasting environments. Nutrient concentrations differences (P≤0.05) were observed among morphological components over time. In environments (Aw1) the morphological components showed higher average protein content in comparison to that from hostile conditions (Aw0); lamina (12.2% vs 10.4%), pseudostem (9.5% vs 6.6%) and sheath (9.8% vs 6.8%). Hostile environments (Aw0) promoted increases for FAD (47.9%, 46.9%, pseudostem …


The Comparative Effects Of Short Duration, High Density And Conventional, Rotational Grazing On Different Soil, Vegetation And Animal Parameters In Dry And Mesic Grasslands Of South Africa, Jamie Paulse, Paul Malan, Nico Smit Mar 2022

The Comparative Effects Of Short Duration, High Density And Conventional, Rotational Grazing On Different Soil, Vegetation And Animal Parameters In Dry And Mesic Grasslands Of South Africa, Jamie Paulse, Paul Malan, Nico Smit

IGC Proceedings (1977-2023)

Short duration, high density grazing is a grazing management strategy that incorporates the rotation of large livestock herds, often at double or triple the normal prescribed stocking densities of the specific area. It is claimed that this type of grazing management can improve rangeland health by improving soil and vegetation condition, and subsequently influencing animal performance. Regardless of the scarcity of scientific evidence validating these claims, the change from conventional rotational grazing systems to short duration, high density grazing systems is on the increase in South Africa. This study aims to assess these claims, through the quantification of various rangeland …


Sustainable Management Of Rangelands: An Assessment Of Invasion Cover Trajectories And Their Contribution To Invasion Management In Marigat Sub-County, Kenya, Beatrice Adoyo, Albrecht Ehrensperger, Mikalitsa S. Mukhovi, Boniface Kiteme, Purity Mbaabu Rima, Sandra Eckert, Simon Choge, Urs Schaffner Mar 2022

Sustainable Management Of Rangelands: An Assessment Of Invasion Cover Trajectories And Their Contribution To Invasion Management In Marigat Sub-County, Kenya, Beatrice Adoyo, Albrecht Ehrensperger, Mikalitsa S. Mukhovi, Boniface Kiteme, Purity Mbaabu Rima, Sandra Eckert, Simon Choge, Urs Schaffner

IGC Proceedings (1977-2023)

Invasive alien species have complex spatiotemporal patterns of spread beyond geographical and jurisdictional boundaries. This calls for a coordinated management approach that is spatially explicit, extends beyond individual plot levels, and incorporates land users’ perceptions and decisions. This study, therefore, aims at assessing spatiotemporal invasion trajectories of the invasive tree Prosopis juliflora in Baringo County, Kenya, and evaluating their possible relation to land users’ management decisions. Pre-classified land cover data over a seven-year time period (1988–2016) were reclassified based on the presence or absence of P. juliflora and integrated into ArcGIS to produce P. juliflora cover trajectories for analysis. The …


Enhancing Grassland Biodiversity And Its Consequences For Grassland Management And Utilisation, Johannes Isselstein Mar 2022

Enhancing Grassland Biodiversity And Its Consequences For Grassland Management And Utilisation, Johannes Isselstein

IGC Proceedings (1977-2023)

Key points

1. Grasslands make an important contribution to the biodiversity of rural landscapes.

2. Biodiversity has the potential to support the production function of grassland. The conditions for this are largely unexplored.

3. The enhancement of biodiversity on agriculturally improved, species-poor grasslands is difficult to achieve due to seed limitation and high residual soil fertility.

4. Measures to overcome constraints are addition of propagules, depletion of soil nutrients, and the use of specific sward treatments.

5. Agri-environmental schemes will play an increasing role in achieving the biodiversity targets in the future, however, the efficiency of such schemes needs improvement.


Assessment Of Relationships Between External Load Metrics And Game Performance In Women’S Lacrosse, Libby Bynum, Ronald Snarr Jr., Bradley Myers 8931361, Jennifer A. Bunn Mar 2022

Assessment Of Relationships Between External Load Metrics And Game Performance In Women’S Lacrosse, Libby Bynum, Ronald Snarr Jr., Bradley Myers 8931361, Jennifer A. Bunn

International Journal of Exercise Science

International Journal of Exercise Science 15(6): 488-497, 2022. The purpose of this study was to analyse the relationship between external load metrics with game performance for Division I collegiate female lacrosse. Data were collected using microtechnology during 26 games with 13 athletes (attackers n = 5, midfielders n = 8). External load variables included: total distance (TD), distance rate (DR), high-intensity (HI) distance, speed, HI sprints, accelerations, decelerations, metabolic equivalent distance (MED), and sprints. For attackers, goals, points, shots, and shots on goal (SOG) had low, positive associations with TD (r = 0.32 to 0.42) and MED (r …


Evaluating Novel Methods Of Classifying Interlimb Asymmetries Within Collegiate American Football Players, Nicolas M. Philipp, Derek A. Crawford, Matthew J. Garver, H. Scott Strohmeyer Mar 2022

Evaluating Novel Methods Of Classifying Interlimb Asymmetries Within Collegiate American Football Players, Nicolas M. Philipp, Derek A. Crawford, Matthew J. Garver, H. Scott Strohmeyer

International Journal of Exercise Science

International Journal of Exercise Science 15(6): 473-487, 2022. Over the last few years, researchers and sport scientists have expressed an increased interest in the effects of interlimb asymmetry on aspects of sport performance such as jumping, sprinting, and changing direction. This study aimed to evaluate the diagnostic utility of three different means of classifying asymmetry to highlight if a 6-week resistance training intervention can meaningfully reduce levels of asymmetry, and to determine the relation between asymmetry reduction and improvements in change of direction (CoD) performance, if any. Eighteen, division-two collegiate American football skill position players completed all pre- and post-intervention …


Acute Ingestion Of A Commercially Available Pre-Workout Supplement Improves Anaerobic Power Output And Reduces Muscular Fatigue, Sotiris Panayi, Andy Galbraith Mar 2022

Acute Ingestion Of A Commercially Available Pre-Workout Supplement Improves Anaerobic Power Output And Reduces Muscular Fatigue, Sotiris Panayi, Andy Galbraith

International Journal of Exercise Science

International Journal of Exercise Science 15(6): 455-472, 2022. The effect of a pre-workout supplement on anaerobic power output and muscular fatigue was examined. 18 participants took part in this double-blinded crossover study, reporting for testing on 3 occasions. Participants completed a 6x6 second repeated sprint test, with 20s recovery between sprints. Anaerobic power output was recorded as the highest power achieved during sprint test. Muscular fatigue was reported as a fatigue index across the six sprints ((maximum power – minimum power) ÷ total sprint time). During a baseline visit, participants consumed 250ml of water 30 minutes prior to testing, whilst …


High-Risk Environmental Conditions Attenuates Performance Efficiency Index In Ncaa Di Female Soccer Players, Maxine Furtado Mesa, Jeffrey R. Stout, David H. Fukuda, Michael J. Redd, Adam J. Wells Mar 2022

High-Risk Environmental Conditions Attenuates Performance Efficiency Index In Ncaa Di Female Soccer Players, Maxine Furtado Mesa, Jeffrey R. Stout, David H. Fukuda, Michael J. Redd, Adam J. Wells

International Journal of Exercise Science

International Journal of Exercise Science 15(6): 442-454, 2022. The purpose of this study was to evaluate the effects of environmental conditions on running performance and performance efficiency index (Effindex). Performance data recorded using Polar Team Pro sensors from eight collegiate female soccer players in nine matches were analyzed during the 2019 competitive season. Effindex and running performance, including total distance covered (TDREL) and distance covered in five speed thresholds relative to minutes played, were examined for indications of fatigue with respect to environmental conditions, including ambient temperature and relative humidity. Matches were separated into three groups based on …


The Impact Of Early Morning Training Sessions On Total Sleep Time In Collegiate Athletes, Brandon Merfeld, Austin Mancosky, Joel Luedke, Shalynn Griesmer, Jacob Erickson, Victoria Carvalho, Andrew R. Jagim Mar 2022

The Impact Of Early Morning Training Sessions On Total Sleep Time In Collegiate Athletes, Brandon Merfeld, Austin Mancosky, Joel Luedke, Shalynn Griesmer, Jacob Erickson, Victoria Carvalho, Andrew R. Jagim

International Journal of Exercise Science

International Journal of Exercise Science 15(6): 423-433, 2022. Early morning training sessions may affect sleep quantity in athletes. The purpose of this study is to examine differences in total sleep time of collegiate athletes on nights prior to early morning training sessions relative to non-training nights. Wristwatch monitors equipped with photoplethysmography and accelerometer technology were worn by 18 NCAA Division III collegiate athletes (Age: 20.1 ± 1.6 years, Height: 1.81 ± 0.02 m, Body Mass: 91.2 ± 6.5 kg, Body Fat %: 20.8 ± 1.6%) during a two-week period of training to monitor total sleep times. Athletes recorded time in …


Comparison Of A Continuous And Discontinuous Gxt On Vo2 In Resistance-Trained And Endurance-Trained Males, Brandon D. Shepherd, Ffion G. Price, Ben Krings, Johneric W. Smith Mar 2022

Comparison Of A Continuous And Discontinuous Gxt On Vo2 In Resistance-Trained And Endurance-Trained Males, Brandon D. Shepherd, Ffion G. Price, Ben Krings, Johneric W. Smith

International Journal of Exercise Science

International Journal of Exercise Science 15(4): 414-422, 2022. Traditional graded exercise testing to assess maximal oxygen uptake (VO2max) may not well represent resistance-trained athletes due to their unfamiliarity with continuous exercise. For this reason, it is possible discontinuous exercise protocols may better represent the maximum capacity for aerobic metabolism in resistance-trained athletes, in order to provide a more valid assessment of VO2max and risk of developing cardiovascular disease. Purpose: The purpose of this experiment was to compare VO2peak during a continuous and discontinuous modified Bruce protocol in both highly resistance-trained and endurance-trained males. Methods: 19 college-aged …


Is It Safe For Hemodialysis Patients To Seek Gains With Less Pain? Acute Hemodynamic Response To Intradialytic Blood Flow Restriction Training, Rony Nobre, Rodrigo Cardoso, Aline Araujo, Rafael Orcy, Jeniffer Aquino, Larissa Ribeiro, Rafaela Catto, Ana Carolina Conteratto, Airton Rombaldi, Maristela Bohlke Mar 2022

Is It Safe For Hemodialysis Patients To Seek Gains With Less Pain? Acute Hemodynamic Response To Intradialytic Blood Flow Restriction Training, Rony Nobre, Rodrigo Cardoso, Aline Araujo, Rafael Orcy, Jeniffer Aquino, Larissa Ribeiro, Rafaela Catto, Ana Carolina Conteratto, Airton Rombaldi, Maristela Bohlke

International Journal of Exercise Science

International Journal of Exercise Science 15(2): 434-441, 2022. Considering that the hemodynamic safety is a major concern about intradialytic exercise with blood flow restriction, this analysis was performed to compare the blood pressure (BP) behavior during the first two hours of hemodialysis (HD) between sessions with no exercise (control group, CG), low/moderate intensity aerobic exercise with blood flow restriction (BFRE) and conventional aerobic exercise (AE). Adult patients with chronic kidney disease on HD at a university hospital were randomly assigned and submitted to a 12-week intradialytic training with BFRE or AE compared with the CG group. The main outcomes of …


Greater Numbers Of Antral Follicles In The Ovary Are Associated With Increased Concentrations Of Glucose In Uterine Luminal Fluid Of Beef Heifers, Alexandria P. Snider, Matthew S. Crouse, Shelby L. Rosasco, Kaitlin M. Epperson, Emmalee J. Northrop-Albrecht, Jerica J.J. Rich, Chadwick C. Chase Jr., Jeremy R. Miles, George A. Perry, Adam F. Summers, Robert A. Cushman Mar 2022

Greater Numbers Of Antral Follicles In The Ovary Are Associated With Increased Concentrations Of Glucose In Uterine Luminal Fluid Of Beef Heifers, Alexandria P. Snider, Matthew S. Crouse, Shelby L. Rosasco, Kaitlin M. Epperson, Emmalee J. Northrop-Albrecht, Jerica J.J. Rich, Chadwick C. Chase Jr., Jeremy R. Miles, George A. Perry, Adam F. Summers, Robert A. Cushman

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Increased antral follicles are associated with greater fertility and a uterine environment that is more supportive of early embryonic development in beef heifers. Glucose is a primary energy source for embryos, and glucose concentrations are elevated in uterine luminal fluid (ULF) of pregnant heifers. We hypothesized that ULF glucose concentrations and endometrial transcript abundance for glucose transporters on d16 after insemination would be greater in heifers with increased numbers of antral follicles. Heifers classified with either increased or diminished antral follicle counts were artificially inseminated following the CO-Synch protocol (d0). On d16 after insemination, reproductive tracts of heifers were collected …


Smokejumper Obituary: Stillman, Albert Theodore “Al” (Mccall 1959), National Smokejumper Association Mar 2022

Smokejumper Obituary: Stillman, Albert Theodore “Al” (Mccall 1959), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.


School Of Culinary Arts And Food Technology Newsletter-Spring Edition 2022, James Murphy Mar 2022

School Of Culinary Arts And Food Technology Newsletter-Spring Edition 2022, James Murphy

Other resources

The School of Culinary Arts and Food Technology, TU Dublin, Spring Newsletter captured the many events, research, awards, significant contributions and special civic and community activities which the students and staff members of the school have successfully completed up to the Spring period of 2022. The successful completion of these activities would not be possible without the active and on-going support of the 'INSPIRED' friends of Culinary Arts (school supporters) and our school's industry association supporters.


Reduction Of Stabilin-2 Contributes To A Protection Against Atherosclerosisstabilin, Yukako Kayashima1*,, Conner A. Clanton, Amanda M. Lewis, Xinghui Sun, Sylvia Hiller, Phillip Huynh, Jennifer Wilder, John Hagaman, Feng Li, Nobuyo Maeda-Smithies, Edward N. Harris Mar 2022

Reduction Of Stabilin-2 Contributes To A Protection Against Atherosclerosisstabilin, Yukako Kayashima1*,, Conner A. Clanton, Amanda M. Lewis, Xinghui Sun, Sylvia Hiller, Phillip Huynh, Jennifer Wilder, John Hagaman, Feng Li, Nobuyo Maeda-Smithies, Edward N. Harris

Department of Biochemistry: Faculty Publications

We have previously identified a novel atherosclerosis quantitative trait locus (QTL), Arch atherosclerosis 5 (Aath5), on mouse chromosome 10 by three-way QTL analyses between Apoe−/− mice on a DBA/2J, 129S6 and C57BL/6J background. The DBA/2J haplotype at the Aath5 locus was associated with smaller plaque size. One of the candidate genes underlying Aath5 was Stabilin-2 (Stab2), which encodes a clearance receptor for hyaluronan (HA) predominantly expressed in liver sinusoidal endothelial cells (LSECs). However, the role of Stab2 in atherosclerosis is unknown. A congenic line of Apoe−/− mice carrying Aath5 covering the Stab2DBA allele …


Reduction Of Stabilin-2 Contributes To A Protection Against Atherosclerosis, Yukako Kayashima, Connor A. Clanton, Amanda M. Lewis, Xinghui Sun, Sylvia Hiller, Phillip Huynh, Jennifer Wilder, John Hagaman, Feng Li, Nobuyo Maeda-Smithies, Ed Harris Mar 2022

Reduction Of Stabilin-2 Contributes To A Protection Against Atherosclerosis, Yukako Kayashima, Connor A. Clanton, Amanda M. Lewis, Xinghui Sun, Sylvia Hiller, Phillip Huynh, Jennifer Wilder, John Hagaman, Feng Li, Nobuyo Maeda-Smithies, Ed Harris

Department of Biochemistry: Faculty Publications

We have previously identified a novel atherosclerosis quantitative trait locus (QTL), Arch atherosclerosis 5 (Aath5), on mouse chromosome 10 by three-way QTL analyses between Apoe−/− mice on a DBA/2J, 129S6 and C57BL/6J background. The DBA/2J haplotype at the Aath5 locus was associated with smaller plaque size. One of the candidate genes underlying Aath5 was Stabilin-2 (Stab2), which encodes a clearance receptor for hyaluronan (HA) predominantly expressed in liver sinusoidal endothelial cells (LSECs). However, the role of Stab2 in atherosclerosis is unknown. A congenic line of Apoe−/− mice carrying Aath5 covering the Stab2 …


Effects Of High-Volume Versus High-Load Resistance Training On Skeletal Muscle Growth And Molecular Adaptations, Christopher G. Vann, Casey L. Sexton, Shelby C. Osburn, Morgan A. Smith, Cody T. Haun, Melissa N. Rumbley, Petey W. Mumford, Nathan T. Montgomery, Bradley A. Ruple, James Mckendry, Jonathan Mcleod, Adil Bashir, Ronald J. Beyers, Matthew S. Brook, Kenneth Smith, Philip J. Atherton, Darren T. Beck, James R. Mcdonald, Kaeilin C. Young, Stuart M. Phillips, Michael D. Roberts Mar 2022

Effects Of High-Volume Versus High-Load Resistance Training On Skeletal Muscle Growth And Molecular Adaptations, Christopher G. Vann, Casey L. Sexton, Shelby C. Osburn, Morgan A. Smith, Cody T. Haun, Melissa N. Rumbley, Petey W. Mumford, Nathan T. Montgomery, Bradley A. Ruple, James Mckendry, Jonathan Mcleod, Adil Bashir, Ronald J. Beyers, Matthew S. Brook, Kenneth Smith, Philip J. Atherton, Darren T. Beck, James R. Mcdonald, Kaeilin C. Young, Stuart M. Phillips, Michael D. Roberts

Faculty Scholarship

We evaluated the effects of higher-load (HL) versus (lower-load) higher-volume (HV) resistance training on skeletal muscle hypertrophy, strength, and muscle-level molecular adaptations. Trained men (n = 15, age: 23 ± 3 years; training experience: 7 ± 3 years) performed unilateral lower-body training for 6 weeks (3× weekly), where single legs were randomly assigned to HV and HL paradigms. Vastus lateralis (VL) biopsies were obtained prior to study initiation (PRE) as well as 3 days (POST) and 10 days following the last training bout (POSTPR). Body composition and strength tests were performed at each testing session, and biochemical assays were …


Assessment Of Diversity Of Antimicrobial Resistance Phenotypes And Genotypes Of Mannheimia Haemolytica Isolates From Bovine Nasopharyngeal Swabs, Hannah F. Carter, Robert W. Wills, Matthew A. Scott, Alexis C. Thompson, Randall S. Singer, John Dustin Loy, Brandi B. Karisch, William B. Epperson, Amelia R. Woolums Mar 2022

Assessment Of Diversity Of Antimicrobial Resistance Phenotypes And Genotypes Of Mannheimia Haemolytica Isolates From Bovine Nasopharyngeal Swabs, Hannah F. Carter, Robert W. Wills, Matthew A. Scott, Alexis C. Thompson, Randall S. Singer, John Dustin Loy, Brandi B. Karisch, William B. Epperson, Amelia R. Woolums

School of Veterinary and Biomedical Sciences: Faculty Publications

The threat of bovine respiratory disease (BRD) for cattle operations is exacerbated by increasing prevalence of antimicrobial resistance (AMR) in Mannheimia haemolytica, a leading cause of BRD. Characterization of AMR in M. haemolytica by culture and susceptibility testing is complicated by uncertainty regarding the number of colonies that must be selected to accurately characterize AMR phenotypes (antibiograms) and genotypes in a culture. The study objective was to assess phenotypic and genotypic diversity of M. haemolytica isolates on nasopharyngeal swabs (NPS) from 28 cattle at risk for BRD or with BRD. NPS were swabbed onto five consecutive blood agar plates; …


Triglyceride-Rich Lipoproteins, Apolipoprotein C-Iii, Angiopoietin-Like Protein 3, And Cardiovascular Events In Older Adults: Atherosclerosis Risk In Communities (Aric) Study, Aliza Hussain, Caroline Sun, Elizabeth Selvin, Vijay Nambi, Josef Coresh, Xiaoming Jia, Christie M Ballantyne, Ron C Hoogeveen Mar 2022

Triglyceride-Rich Lipoproteins, Apolipoprotein C-Iii, Angiopoietin-Like Protein 3, And Cardiovascular Events In Older Adults: Atherosclerosis Risk In Communities (Aric) Study, Aliza Hussain, Caroline Sun, Elizabeth Selvin, Vijay Nambi, Josef Coresh, Xiaoming Jia, Christie M Ballantyne, Ron C Hoogeveen

Faculty, Staff and Students Publications

AIMS: Despite statin and antihypertensive therapies, older Americans have high atherosclerotic cardiovascular disease (ASCVD) risk. Novel measures of triglyceride-rich lipoproteins, low-density lipoprotein triglycerides (LDL-TG), and remnant-like particle cholesterol (RLP-C), are associated with ASCVD in middle-aged adults. Polymorphisms in genes encoding angiopoietin-related protein 3 (ANGPTL3) and apolipoprotein C-III (apoC-III), two proteins involved in triglyceride catabolism, are associated with increased risk for hypertriglyceridaemia and ASCVD and are potential therapeutic targets. We examined associations of LDL-TG, RLP-C, apoC-III, and ANGPTL3 levels with ASCVD events in older adults in the Atherosclerosis Risk in Communities (ARIC) study.

METHODS AND RESULTS: In 6359 participants (mean age …


Thinking Outside The Box Of Evaluation Platforms: Adapting Qualtrics For Virtual 4-H Judging Competitions, Maria Calvert, Ty Peckman Mar 2022

Thinking Outside The Box Of Evaluation Platforms: Adapting Qualtrics For Virtual 4-H Judging Competitions, Maria Calvert, Ty Peckman

Journal of Extension

Competitive events represent a major component of 4-H programming. These events are typically held in person; however, unforeseen circumstances, like the COVID-19 pandemic, have required Extension professionals to adapt these programs to virtual settings. This paper outlines some unique features of Qualtrics, a web-based tool commonly used to build surveys, that led Missouri 4-H to use the platform to administer agriculture and natural resource science contests.


Iowa Wine Industry And Its Educational Needs, Aude A. Watrelot Mar 2022

Iowa Wine Industry And Its Educational Needs, Aude A. Watrelot

Journal of Extension

The grape and wine industry in Iowa is based on non-Vitis vinifera grapes, which are not well-known and come with their own set of challenges. An industry survey revealed that wine business and marketing are the main concerns for the Iowa grape and wine industry members. The educational resources already provided by Extension personnel were highly appreciated and events should be offered in several locations around Iowa. The main topics of roundtables and discussions should be about vineyard management and winemaking practices, specifically practices to avoid microbial spoilage, to reduce wine acidity and to select appropriate yeasts for fermentation.


Water Conservation: Extension Agents’ Perceptions Of Issue Importance, Professional Abilities, And Landowner Needs, Audrey Mccrary, Leslie M. Burger, Laura Downey, Beth H. Baker Mar 2022

Water Conservation: Extension Agents’ Perceptions Of Issue Importance, Professional Abilities, And Landowner Needs, Audrey Mccrary, Leslie M. Burger, Laura Downey, Beth H. Baker

Journal of Extension

The Extension Service is one of many agencies charged with increasing awareness and knowledge of research-based agricultural conservation practices. A regional survey of Extension agents with agriculture and natural resources responsibilities was conducted to assess the need for in-service training on 11 water resource conservation topics. The highest priority training needs were for topics related to complex interactions and drivers of agricultural water pollution. This article highlights the implications of these results and offers broader perspective on bringing the Borich model of needs assessment into the agricultural and natural resources realm of subject matter expertise.


Synergy Of Venetoclax And 8-Chloro-Adenosine In Aml: The Interplay Of Rrna Inhibition And Fatty Acid Metabolism, Dinh Hoa Hoang, Corey Morales, Ivan Rodriguez Rodriguez, Melissa Valerio, Jiamin Guo, Min-Hsuan Chen, Xiwei Wu, David Horne, Varsha Gandhi, Lisa S Chen, Bin Zhang, Vinod Pullarkat, Steven T Rosen, Guido Marcucci, Ralf Buettner, Le Xuan Truong Nguyen Mar 2022

Synergy Of Venetoclax And 8-Chloro-Adenosine In Aml: The Interplay Of Rrna Inhibition And Fatty Acid Metabolism, Dinh Hoa Hoang, Corey Morales, Ivan Rodriguez Rodriguez, Melissa Valerio, Jiamin Guo, Min-Hsuan Chen, Xiwei Wu, David Horne, Varsha Gandhi, Lisa S Chen, Bin Zhang, Vinod Pullarkat, Steven T Rosen, Guido Marcucci, Ralf Buettner, Le Xuan Truong Nguyen

Faculty, Staff and Student Publications

It is known that 8-chloro-adenosine (8-Cl-Ado) is a novel RNA-directed nucleoside analog that targets leukemic stem cells (LSCs). In a phase I clinical trial with 8-Cl-Ado in patients with refractory or relapsed (R/R) AML, we observed encouraging but short-lived clinical responses, likely due to intrinsic mechanisms of LSC resistance. LSC homeostasis depends on amino acid-driven and/or fatty acid oxidation (FAO)-driven oxidative phosphorylation (OXPHOS) for survival. We recently reported that 8-Cl-Ado and the BCL-2-selective inhibitor venetoclax (VEN) synergistically inhibit FAO and OXPHOS in LSCs, thereby suppressing acute myeloid leukemia (AML) growth in vitro and in vivo. Herein, we report that 8-Cl-Ado …


A Novel Proton-Integrating Radiography System Design Using A Monolithic Scintillator Detector: Experimental Studies, Chinmay D Darne, Daniel G Robertson, Fahed Alsanea, Charles-Antoine Collins-Fekete, Sam Beddar Mar 2022

A Novel Proton-Integrating Radiography System Design Using A Monolithic Scintillator Detector: Experimental Studies, Chinmay D Darne, Daniel G Robertson, Fahed Alsanea, Charles-Antoine Collins-Fekete, Sam Beddar

Faculty, Staff and Student Publications

Research on proton-based imaging systems aims to improve treatment planning, internal anatomy visualization, and patient alignment for proton radiotherapy. The purpose of this study was to demonstrate a new proton radiography system design consisting of a monolithic plastic scintillator volume and two optical cameras for use with scanning proton pencil beams. Unlike the thin scintillating plates currently used for proton radiography, the plastic scintillator volume (20 × 20 × 20 cm


Physiological Responses To Acute Cycling With Blood Flow Restriction, Matthew A. Kilgas, Tejin Yoon, John Mcdaniel, Kevin Phillips, Steve Elmer Mar 2022

Physiological Responses To Acute Cycling With Blood Flow Restriction, Matthew A. Kilgas, Tejin Yoon, John Mcdaniel, Kevin Phillips, Steve Elmer

Michigan Tech Publications, Part 1

Aerobic exercise with blood flow restriction (BFR) can improve muscular function and aerobic capacity. However, the extent to which cuff pressure influences acute physiological responses to aerobic exercise with BFR is not well documented. We compared blood flow, tissue oxygenation, and neuromuscular responses to acute cycling with and without BFR. Ten participants completed four intermittent cycling (6 × 2 min) conditions: low-load cycling (LL), low-load cycling with BFR at 60% of limb occlusion pressure (BFR60), low-load cycling with BFR at 80% of limb occlusion pressure (BFR80), and high-load cycling (HL). Tissue oxygenation, cardiorespiratory, metabolic, and perceptual responses were assessed during …


Deepreal: A Deep Learning Powered Multi-Scalemodeling Framework For Predicting Out-Of-Distributionligand-Induced Gpcr Activity, Tian Cai, Kyra Alyssa Abbu, Yang Liu, Lei Xie Mar 2022

Deepreal: A Deep Learning Powered Multi-Scalemodeling Framework For Predicting Out-Of-Distributionligand-Induced Gpcr Activity, Tian Cai, Kyra Alyssa Abbu, Yang Liu, Lei Xie

Publications and Research

Motivation Drug discovery has witnessed intensive exploration of predictive modeling of drug–target physical interactions over two decades. However, a critical knowledge gap needs to be filled for correlating drug–target interactions with clinical outcomes: predicting genome-wide receptor activities or function selectivity, especially agonist versus antagonist, induced by novel chemicals. Two major obstacles compound the difficulty on this task: known data of receptor activity is far too scarce to train a robust model in light of genome-scale applications, and real-world applications need to deploy a model on data from various shifted distributions.

Results To address these challenges, we have developed an end-to-end …


The Ability To Classify Patients Based On Gene-Expression Data Varies By Algorithm And Performance Metric, Stephen Piccolo, Avery Mecham, Nathan P. Golightly, Jérémie L. Johnson, Dustin B. Miller Mar 2022

The Ability To Classify Patients Based On Gene-Expression Data Varies By Algorithm And Performance Metric, Stephen Piccolo, Avery Mecham, Nathan P. Golightly, Jérémie L. Johnson, Dustin B. Miller

Faculty Publications

By classifying patients into subgroups, clinicians can provide more effective care than using a uniform approach for all patients. Such subgroups might include patients with a particular disease subtype, patients with a good (or poor) prognosis, or patients most (or least) likely to respond to a particular therapy. Transcriptomic measurements reflect the downstream effects of genomic and epigenomic variations. However, high-throughput technologies generate thousands of measurements per patient, and complex dependencies exist among genes, so it may be infeasible to classify patients using traditional statistical models. Machine-learning classification algorithms can help with this problem. However, hundreds of classification algorithms exist—and …


A Revision Of The Genus Mesobuthus Vachon, 1950, With A Description Of 14 New Species (Scorpiones: Buthidae), František Kovařík, Victor Fet, Benjamin Gantenbein, Matthew R. Graham, Ersen A. Yağmur, František Šťáhlavský, Nikita M. Poverennyi, Nizami E. Novruzov Mar 2022

A Revision Of The Genus Mesobuthus Vachon, 1950, With A Description Of 14 New Species (Scorpiones: Buthidae), František Kovařík, Victor Fet, Benjamin Gantenbein, Matthew R. Graham, Ersen A. Yağmur, František Šťáhlavský, Nikita M. Poverennyi, Nizami E. Novruzov

Euscorpius

The Asian genus Mesobuthus Vachon, 1950, s. str. (Buthidae) (also known as an informal ‘M. eupeus complex’), which includes the most common scorpion species found from Turkey to China, is revised based on new collections, mainly from Central Asia, Turkey, and Iran, using both morphological and mitochondrial DNA data. Available type specimens of all species were studied; neotypes and lectotypes were designated when necessary. The type species Mesobuthus eupeus (C. L. Koch, 1839), s. str., is restricted to the Caucasus Mts. Currently, the genus includes 29 valid species. Fifteen previously described taxa are recognized as species: Mesobuthus afghanus (Pocock, …


Examining Farm Financial Management: How Do Small Us Farms Meet Their Agricultural Expenses?, Omobolaji Omobitan, Aditya R. Khanal Mar 2022

Examining Farm Financial Management: How Do Small Us Farms Meet Their Agricultural Expenses?, Omobolaji Omobitan, Aditya R. Khanal

Agricultural and Environmental Sciences Faculty Research

Small farms in the US have significant challenges in financial management. This study examines how small farmers undertake farm financial management to meet their agricultural and farm-related spending and expenses. Using primary survey data from Tennessee, the study investigates the factors influencing the extent of use of five financing sources to meet the spending and expenses: cash/fund directly generated from the sale of agricultural products, farmer’s past savings, farm household’s off-farm income, income/incentives from government payments, and external loans. Using negative binomial regression estimation of generalized linear models, findings suggest that the decision on the use of financing sources is …