Life Sciences Commons^™

Pneumonia, Munachiso Onwuameze '24, Kosi Okeke '24, Destiny Grant '23

Human Diseases Graphic Novels

No abstract provided.

The Digestive System, Elle Brittin '23, Gwen Olney '24

Human Diseases Graphic Novels

No abstract provided.

Peptic Ulcer, Shanan Riley '23, Grace Daum '23, Sophia Syed '23, Elizabeth Carlson '23

Human Diseases Graphic Novels

No abstract provided.

Hashimoto's Disease, Madilyn Bulfer, Yareli Marinez, Halimat Sanusi

Human Diseases Graphic Novels

No abstract provided.

Temporal Trends In Lipoprotein(A) Concentrations: The Atherosclerosis Risk In Communities Study, Matthew R. Deshotels, Caroline Sun, Vijay Nambi, Salim S. Virani, Kunihiro Matsushita, Bing Yu, Christie . M. Ballantyne, Ron C. Hoogeveen

Office of the Provost

Background: Plasma lipoprotein(a) (Lp[a]) concentrations are primarily determined by genetic factors and are believed to remain stable throughout life. However, data are scarce on longitudinal trends in Lp(a) concentrations over time. Therefore, it is unclear whether measurement of Lp(a) once in a person's life is sufficient for cardiovascular risk assessment in all adults.
Methods and Results: Lp(a) concentrations, specifically apolipoprotein(a) concentrations, were measured at visits 4 and 5, ≈15 years apart, in 4734 adult participants of the ARIC (Atherosclerosis Risk in Communities) study (mean age at visits 4 and 5, 60.7±5.1 and 75.5±5.2 years, respectively). Participants were categorized by baseline …

The Effects Of Cheatgrass Invasion On Us Great Basin Carbon Storage Depend On Interactions Between Plant Community Composition, Precipitation Seasonality, And Soil Climate Regime, Toby M. Maxwell, Matthew J. Germino

Biology Faculty Publications and Presentations

1. Annual-grass invasions are transforming desert ecosystems in ways that affect ecosystem carbon (C) balance, but previous studies do not agree on the pattern, magnitude and direction of changes. A recent meta-analysis of 41 articles and 386 sites concludes that invasion by annual grasses such as cheatgrass (Bromus tectorum L) reduces C in biomass across the Great Basin (Nagy et al., 2021). Reanalysis reveals that whether cheatgrass affects biomass C stocks is not generalizable, but rather depends on the considerable variation in climate across the subject sites. Our analysis suggests that accurate Great Basin-scale estimates of cheatgrass effects on C …

Nucleobase-Modified Nucleosides And Nucleotides: Applications In Biochemistry, Synthetic Biology, And Drug Discovery, Anthony J. Berdis

Chemistry Faculty Publications

DNA is often referred to as the "molecule of life " since it contains the genetic blueprint for all forms of life on this planet. The core building blocks composing DNA are deoxynucleotides. While the deoxyribose sugar and phosphate group are ubiquitous, it is the composition and spatial arrangement of the four natural nucleobases, adenine (A), cytosine (C), guanine (G), and thymine (T), that provide diversity in the coding information present in DNA. The ability of DNA to function as the genetic blueprint has historically been attributed to the formation of proper hydrogen bonding interactions made between complementary nucleobases. However, …

Pestfacts Wa Issue 21 - November 2022, Cindy L. Webster, Ciara Beard, Geoff J. Thomas

PestFacts WA

PestFacts WA Issue 21 - November 2022 contents:

• Final PestFacts WA newsletter for 2022!
• Green bridge management over summer
• PestFacts WA continues successful collaboration with Agworld and Back Paddock

Modeling Vegetation Cover At Mount St Helens Using Highly Correlated Vegetation Indices, Sara Livingston

Geography and the Environment: Graduate Student Capstones

The eruption of Mount St. Helens in 1980 devastated the landscape and obliterated all ground vegetation within a 620 km2 blast zone radius. The destructive forces of the lateral blast, debris avalanche, tephra plume, and lahar flow created a complex mosaic of disturbance zones, that subsequently yielded various rates of landscape recovery. Remote sensing is an efficient method for monitoring landscape-scale changes by recording the distinct spectral reflectance of vegetation. Based on statistically significant correlations between Vegetation Indices and vegetation parameters, an empirical model can be developed for vegetation cover predictions. This capstone analysis found that NDVI holds the strongest …

[Rare-Disease Data Standards]., Peter N Robinson, Holm Graessner

Faculty Research 2022

The use of standardized data formats (data standards) in healthcare supports four main goals: (1) exchange of data, (2) integration of computer systems and tools, (3) data storage and archiving, and (4) support of federated databases. Standards are especially important for rare-disease research and clinical care.In this review, we introduce healthcare standards and present a selection of standards that are commonly used in the field of rare diseases. The Human Phenotype Ontology (HPO) is the most commonly used standard for annotating phenotypic abnormalities and supporting phenotype-driven analysis of diagnostic exome and genome sequencing. Numerous standards for diseases are available that …

2022 Survey For Midwestern Producers Descriptive Results, Tong Wang, Stephen Cheye

Midwestern Farm and Producer Surveys and Policy Briefs

From July to September 2021, researchers at South Dakota State University carried out a survey of producers in the Midwest to understand producers’ views and use of conservation farming and precision technology. To further understand how the input market supply volatilities has affected Midwest farmers' decisions and their potential adjustments to the current market situation, we carried out a re-survey in 2022 with the 1,119 respondents to the 2021 Midwestern survey. The participants of the survey were contacted in four separate rounds in line with the modified Tailored Design Method.

The Nebraska Bird Review, Subscription And Organization Information (December 2022)

Nebraska Bird Review

The Nebraska Bird Review is published quarterly by the Nebraska Ornithologists’ Union, Inc., as its official journal, and is sent to members not in arrears of dues. Annual subscription rates (on a calendar-year basis only): $25 in the United States and $35 in all other countries, payable in advance. Single copies are $7 each, postpaid, in the United States and $9 elsewhere. Send orders for back issues to Anita Breckbill, NOU Librarian, c/o Music Library, WMB 30, University of Nebraska, Lincoln, NE 68588-0101 (or at the email address listed below).

Memberships in the NOU (on a calendar-year basis only): Active …

Fall Field Report, August-November 2022, W. Ross Silcock

Nebraska Bird Review

All in all, this was a fairly uneventful fall season, although even uneventful seasons have their share of oddities and variations from the norm. A noteworthy event was a fire that took out much of the brushy habitat in Carter Canyon, Scotts Bluff Co (see photo on following page). It will be interesting to read upcoming spring reports to see what effect the fire might have had on numbers of birds that frequent brushy areas, like towhees and buntings. Optimistically, fires have attracted rare woodpeckers, with first to arrive Black-backed, which would be a first documented Nebraska record, and typically …

Forage News [2022-11], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

No abstract provided.

Purification And Characterization Of An Anti-Basigin Monoclonal Antibody: Application To The Study Of Human Uterine Cells And Tissues, Jeannine M. Barna

All NMU Master's Theses

Between 1990 and 2017, the global rate of female infertility increased by over 15% (Sun et al., 2019). An embryo's failure to implant into the uterus is the primary cause of early pregnancy loss. Several studies have identified molecules necessary for successful implantation, but their function during implantation remains poorly understood (S. Zhang et al., 2013). The cell surface glycoprotein basigin-2 is necessary for embryo implantation in the mouse and plays a role in several cellular functions, including cell communication and extracellular matrix remodeling (Chen et al., 2009; K. Li & Nowak, 2020). In vitro studies using human uterine cells …

Larval Fish Export In Response To Varying Compensating Gate Discharge At The Sault Rapids, St. Marys River, Signe F.K. Vandrunen

All NMU Master's Theses

The St. Marys River (SMR) forms the border between Michigan, USA and Ontario, Canada connecting lakes Superior and Huron. Discharge is controlled by a compensating gate system upstream of the SMR rapids. Because spring and summer discharge fluctuates widely, resource managers required information on how flow variability influences larval fish drift. I estimated annual larval fish export in relation to variable discharge during 2018-2021 and compared results to published habitat model predictions. Mean discharge and water temperature were lowest in 2021 and highest in 2019. Water warming rates during high discharge differed from low discharge trends. Across years, I identified …

Effects Of Intercropping On Garlic Growth In A Green Roof Setting, Kennedy Warden, Thomas Loose, Max Stone

Science University Research Symposium (SURS)

Growing crops together in the same plot, also known as intercropping, can increase soil nutrient quality and growth patterns for plants of different species. The purpose of this experiment was to determine the effect of intercropping on the growth of garlic planted on a green roof, specifically the question, “does garlic grow better in a mixed group of different species, or better in a primarily single-species group?” We divided a 2-meter plot in half, one half was devoted to garlic only while the second plot was garlic mixed with strawberries and chili peppers. We predicted that the garlic in the …

The Effect Of Corn Silage Hybrid And Inclusion On Performance Of Finishing Steers And Silage Hybrid Effects On Digestibility And Performance Of Growing Steers, F. Henry Hilscher, Curt J. Bittner, Jana L. Gramkow, Melissa L. Jollyy-Breithaupt, Mitch M. Norman, Hannah C. Wilson, Andrea K. Watson, James C. Macdonald, John N. Anderson, Galen E. Erickson

Department of Animal Science: Faculty Publications

Three experiments evaluated the effects of three corn silage hybrids, inclusion, and nutrient digestibility in growing and finishing diets. The three hybrids tested included a control (CON), a hybrid containing a brown midrib (bm3) trait (BM3), and an experimental bm3 hybrid with the soft endosperm trait (BM3-SOFT). Experiment 1 utilized 360 crossbred steers (body weight [BW] = 334; SD = 25 kg) to evaluate inclusion of silage in a finishing diet at (15% or 45% of diet dry matter [DM]) and silage hybrid (CON, BM3, or BM3-SOFT). Experiment 2 and 3 utilized 216 crossbred steers (BW = 324; SD = …

The Casnr L.I.N.K.S. Newsletter: Learning Innovation Network For K-12 Schools, Edition 10, November 2022, Bailey Feit, Tammy Mittelstet

CASNR L.I.N.K.S. Newsletter

The purpose of this L.I.N.K.S. newsletter is to provide a monthly update of opportunities and resources for K-12 schools to connect with the University of Nebraska's CASNR Food, Energy, Water, and Societal Systems (FEWS²) programs and partners.

Included in this edition:

Curriculum and classroom resources for all levels

K-12 Partners website is live

Eye on curriculum and resources

Teacher opportunities

Link to list of new partnerships

Ask an expert

Eye on CASNR research: Yu Feng Ge

Student experiences

Send your students to campus: Husker weekday visit

Success stories: Art, science, and ag combine in a mural and Lincoln Northeast High …

Growth Performance And Activities Of Some Liver Enzymes In Clarias Gariepinus Burchell 1822 Juveniles Cultured In A Water Hyacinth (Eichhornia Crassipes [Mart] Solms-Laubach) Infested Media, Phebian Temitope Odufuwa

Ecology, Evolution, and Behavior

A 12-week exposure study was conducted to evaluate the growth performance and activities of some liver enzymes of African catfish (Clarias gariepinus) juveniles cultured in water hyacinth (Eichhornia crassipes) infested concrete and plastic culture media. 152 fish juveniles were introduced into two large concrete tanks (6.0 m × 5.0 m × 1.2 m) for the outdoor experiment. A tank was infested with E. crassipes plant at a density of 12.30 plants/m², while the other tank, which served as the control, contained no water hyacinth plant. For the laboratory experiment, 50 fish juveniles were stocked in duplicate into five …

Evaluation Of Wheat-Specific Peptide Targets For Use In The Development Of Elisa And Mass Spectrometry-Based Detection Methods, Jessica Humphrey

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Individuals with IgE-mediated wheat allergy and celiac disease must avoid the consumption of wheat. Those with celiac disease must also avoid rye and barley in addition to wheat as these make up the gluten-containing grains. To ensure products are accurately labeled, ELISA methods may be used to monitor compliance with food allergen and gluten-free regulations. Currently, available ELISA methods for wheat detection utilize monoclonal antibodies that target peptides from the gluten fraction of proteins, and therefore, also detect rye and barley. Limitations such as differing antibody reactivity and unequal gluten content among wheat, rye, and barley have led to inconsistent …

Insights Into Novel Therapeutic Targets And Molecular Aspects In Polycystic Ovarian Syndrome: A Review, Rukaiah Fatma Begum, M. Sumithra, V. Chitra, Sharmila Devi

The Thai Journal of Pharmaceutical Sciences

Polycystic ovarian syndrome (PCOS) is a common endocrine syndrome in women associated with many other complications such as insulin resistance, obesity, hirsutism, increased risk of cardiovascular diseases, and infertility. As the pathophysiology of the syndrome still is not clear, it is difficult for the health-care professionals to precisely treat the syndrome. The cause of this syndrome is also unknown, but the evidences suggest that the factors such as environment, diet, and lifestyle are also a very common cause now a day for the syndrome. Recent pathophysiology of PCOS based on the Anti-Mullerian Hormone (AMH) and melatonin levels has been seen …

Efficacy Of Investigative Candidate Drugs Against Sars Cov-2: An Update On Pre-Clinical And Clinical Trials, Maryam Bibi, Aatika Sadia, Muhammad Shahzad, Ahmad Irfan, Muhammad Asim Raza Basra

The Thai Journal of Pharmaceutical Sciences

The unprecedented challenges presented by COVID-19 pandemic demands for an urgent development of effective therapeutic strategies against the deadly virus. Researchers thus far have revealed outcomes of pre-clinical and clinical studies of different interventions. This study aims to present overall summary of therapeutics that until this date are reported for their efficacy against COVID-19 in pre-clinical and clinical trials. A thorough literature search was conducted using databases for identification of studies published on the severe acute respiratory syndrome CoV (SARS COV-2) treatment. According to pre-clinical experiments, Nefamostat mesylate, Remdesivir, Chloroquine (CQ), Hydroxychloroquine (HCQ), β-D-N4-hydroxycytidine (NHC EIDD-1931), Ivermectin, Boceprevir, Calpain inhibitors, …

Assessment Of Risk Factors And Prescription Analysis Among Embolic And Atherosclerotic Stroke Patients In A Charitable Hospital-A Retrospective Study, Shanty Mary Jose, Amala Johnson, Akshay Abraham, Uday Venkat Mateti, Adithi Kellarai, Raushan Kumar Chaudhary, Shraddha Shetty

The Thai Journal of Pharmaceutical Sciences

Purpose: Despite the burden of stroke globally, there is a lack of data on the current clinical profile of stroke in middle and low-income countries including, India. Hence, the purpose of this study was to identify risk factors, clinical presentations, and importantly, prescription trends in ischemic stroke patients. Methods: A retrospective study was conducted for six months using data of 350 ischemic stroke patients for the analysis of risk factors and prescription pattern. Results: The incidence of ischemic stroke was higher (66%) in males in compared to (34%) females with mean age of 61.07 ± 11.460. Further the atherosclerotic stroke …

Hepatotoxic And Nephrotoxic Effects Of Chronic Exposure To Vernonia Cinerea Crude Extract On Wistar Rats, Thularath Toommakorn, Sajee Waramit, Patchara Danaisawadi, Kantimanee Pradermwong

The Thai Journal of Pharmaceutical Sciences

Vernonia cinerea L. (VC) has been used for smoking cessation and decreased appetite in Thailand. However, the safety of this plant concerning long-term consumption has never been reported. A 6-month toxicity study of VC water crude extract (VCWE) was performed in both genders of Wistar rats at doses of 15, 150, and 1500 mg/kg body weight/day orally. Recovery group received 1500 mg/kg for 6 months and then extended for 14 days without the extract. It was found that the males could not tolerate the highest dose of VCWE. There was no effect on bodyweight, relative organ weight, nor hematological parameters …

Anti-Diabetic Effect Of Interruptins A And B From Cyclosorus Terminans On Mouse Hepatocytes, Sujinda Songtrai, Sireewan Kaewsuwan

The Thai Journal of Pharmaceutical Sciences

Interruptin B from the fern Cyclosorus terminans has been indicated as a ligand of peroxisome proliferator-activated receptor (PPAR)-α and -γ that is known to regulate glucose homeostasis. Interruptin B was previously been implicated to promote glucose consumption into adipocytes. This study aimed to examine the anti-diabetic impact of interruptins A and B on glucose uptake and glycogen synthesis in mouse hepatocytes. Cell viability of FL83B hepatocytes affected by interruptins A and B was determined. The glucose consumption after 12–24 h treatment with compounds was evaluated by glucose oxidase method. The glycogen content was assessed after 24 h incubation using anthrone …

Alcl3 Induced Neuroinflammation And Excitotoxicity In Brain Striatum Mediated Memory And Motor Dysfunction Ameliorated Via Scopoletin Enriched Canscora Decussata Extract, A. Roja, T. Ambiga, Abdul Khayum, Sulaiman Mohammed, Venkatesh Gunasekaran

The Thai Journal of Pharmaceutical Sciences

Objective: Scopoletin is one of the dynamic and active constituents originate in Canscora decussata (CD) herb from Shankhpushpi family according to Indian system of medicine. This study aimed to characterize and to explore the role of scopoletin enriched CD (SECD) extract on AlCl3-induced neuroinflammation and excitotoxicity in rat model. Methodology & Results: High-performance thin-layer chromatography finger printing of ethanol extract of CD confirmed that enriched scopoletin presence as its main constituent. AlCl3 induced behavioural changes were reversed after SECD (200 and 400 mg/kg, i. p) and Rivastigmine (0.3 mg/kg, i.p) treatment by the way of Y maze, Rota rod, and …

Anti-Inflammatory Activity Of Phenolic-Rich Fraction Of Pandanus Tectorius Fruits Via Reduction Of No Production On Lipopolysaccharide-Stimulated Raw264.7 Cell Lines And Formalin-Induced Paw Oedema, Yosie Andriani, Nadia Madihah Ramli, Noor Suryani Musa, Kanwal Kanwal, Habsah Mohamad, Hermansyah Amir, Murni Nur Islamiah Kassim, Desy Fitrya Syamsumir, Tengku Sifzizul Tengku Muhammad, Suvik Assaw

The Thai Journal of Pharmaceutical Sciences

Background: The current study is the first study that investigated the potential of phenolic-rich fraction of Pandanus tectorius fruits as an anti-inflammatory agent. The fruit is rich in phenolic compounds, especially from the flavonoids group. Phenolics are known to contribute to an anti-inflammatory activity. Objectives: The first objective of the study was to evaluate the anti-inflammatory potency of phenolic-rich fractions of P. tectorius fruits by in vitro and in vivo studies. The second was to investigate the cytotoxicity against RAW264.7 cell lines, antioxidant, and phenolic contents to support the experiment. Materials and Methods: Sample fractionation was done with hexane, ethyl …

Antioxidant And Nephroprotective Effects Of Delphinium Denudatum Root Extract (Medicinal Plant) Against Gentamicin-Induced Nephrotoxicity, Nadeem Ahmad Siddique

The Thai Journal of Pharmaceutical Sciences

Introduction and Objectives: Kidney is a front line organ exposed to the toxicity of gentamicin. The objective of this study was to determine the biopotential of Delphinium denudatum Wall., root a significant medicinal plant, against gentamicin. Materials and Methods: By performing high-performance liquid chromatography, an in vitro antioxidant study was conducted against diphenylpicrylhydrazide (DPPH). In vivo nephroprotective activity was evaluated by administering solo administration of gentamicin (GM; 40 mg/kg b.wt. single dose s.c.) for a period of 1st–13th days followed by hydroalcoholic extract of D. denudatum (HAEDD; 200, 400, and 800 mg/kg b.wt. intragastrically) to the rats for 14th–23rd days. …

Antidiabetic Study And Teratogenicity Evaluation Of Ethanolic Extract Of Chromolaena Odorata Linn., Indah Solihah, Yuni Fitriani, Meutia Reni Noprida, Herlina, Riana Sari Puspita Rasyid, Tri Suciati

The Thai Journal of Pharmaceutical Sciences

There is considerable interest in herbal medicine in developing antidiabetic alternative therapy based on plant-derived compounds that would reduce oral hypoglycemic agent-related adverse effects while staying safe during pregnancy. The purpose of this in vivo study was to evaluate the ethanolic extract of Chromolaena odorata L. leaves (ECOL) in alloxan-induced diabetes and its teratogenic effect. The hypoglycemic impact of ECOL increased when the extract dose was raised. Three doses of ECOL (125, 250, and 500 mg/kg body weight) showed a 27.29%, 34.68%, and 52.24% hypoglycemic effect, respectively. While, the standard insulin (1 IU/kg BW) group shown a 31.38% hypoglycemic effect …