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Articles 47041 - 47070 of 255953

Full-Text Articles in Life Sciences

Genotype Classification Of Moraxella Bovis Using Maldi-Tof Ms Profiles, Hannah G. Olson, John Dustin Loy, Michael L. Clawson, Emily L. Wynn, Matthew M. Hille Dec 2022

Genotype Classification Of Moraxella Bovis Using Maldi-Tof Ms Profiles, Hannah G. Olson, John Dustin Loy, Michael L. Clawson, Emily L. Wynn, Matthew M. Hille

Nebraska Center for Virology: Faculty Publications

Moraxella bovis (M. bovis) is regarded as a causative agent of infectious bovine keratoconjunctivitis (IBK), the most common ocular disease of cattle. Recently, whole genome sequencing identified the presence of two distinct genotypes within M. bovis that differ in chromosome content, potential virulence factors, as well as prophage and plasmid profiles. It is unclear if the genotypes equally associate with IBK or if one is more likely to be isolated from IBK lesions. We utilized 39 strains of M. bovis that had previously undergone whole genome sequencing and genotype classification to determine the utility of matrix-assisted laser desorption/ionization …

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Genotype Classification Of Moraxella Bovis Using Maldi-Tof Ms Profiles, Hannah G. Olson, John Dustin Loy, Michael L. Clawson, Emily L. Wynn, Matthew M. Hille Dec 2022

Genotype Classification Of Moraxella Bovis Using Maldi-Tof Ms Profiles, Hannah G. Olson, John Dustin Loy, Michael L. Clawson, Emily L. Wynn, Matthew M. Hille

School of Veterinary and Biomedical Sciences: Faculty Publications

Moraxella bovis (M. bovis) is regarded as a causative agent of infectious bovine keratoconjunctivitis (IBK), the most common ocular disease of cattle. Recently, whole genome sequencing identified the presence of two distinct genotypes within M. bovis that differ in chromosome content, potential virulence factors, as well as prophage and plasmid profiles. It is unclear if the genotypes equally associate with IBK or if one is more likely to be isolated from IBK lesions. We utilized 39 strains of M. bovis that had previously undergone whole genome sequencing and genotype classification to determine the utility of matrix-assisted laser desorption/ionization …

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Intestinal Gas Production By The Gut Microbiota: A Review, Erasme Mutuyemungu, Mukti Singh, Sean Liu, Devin J. Rose Dec 2022

Intestinal Gas Production By The Gut Microbiota: A Review, Erasme Mutuyemungu, Mukti Singh, Sean Liu, Devin J. Rose

Department of Food Science and Technology: Faculty Publications

In addition to causing embarrassment, intestinal gas can be associated with more serious symptoms. This review provides an overview of gas production by the human gut microbiome and outlines foods associated with intestinal gas. Bacteroides, Ruminococcus, Roseburia, Clostridium, Eubacterium, Desulfovibrio, and Methanobrevibacter are among the most abundant microbes responsible for intestinal gas. More than 99% of intestinal gas is composed of hydrogen, carbon dioxide, and methane, while less than 1% is composed of other odiferous compounds. Food groups associated with intestinal gas include pulses, vegetables, fruits, grains, and, for some individuals, dairy. These foods are …

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Whole Genome Sequencing Identifies Structural Variants Contributing To Hematologic Traits In The Nhlbi Topmed Program, Doruk Beyter, Caitlin P Mchugh, John Lane, Min-Zhi Jiang, Laura M Raffield, Goo Jun, Fritz J Sedlazeck, Ginger Metcalf, Yao Yao, Joshua B Bis, Nathalie Chami, Paul S De Vries, Pinkal Desai, James S Floyd, Yan Gao, Kai Kammers, Wonji Kim, Jee-Young Moon, Lisa R Yanek, Laura Almasy, Lewis C Becker, John Blangero, Michael H Cho, Joanne E Curran, Myriam Fornage, Robert C Kaplan, Joshua P Lewis, Ruth J F Loos, Braxton D Mitchell, Alanna C Morrison, Michael Preuss, Bruce M Psaty, Stephen S Rich, Jerome I Rotter, Hua Tang, Russell P Tracy, Eric Boerwinkle, Goncalo R Abecasis, Thomas W Blackwell, Albert V Smith, Andrew D Johnson, Rasika A Mathias, Deborah A Nickerson, Matthew P Conomos, Yun Li, Unnur Þorsteinsdóttir, Magnús K Magnússon, Kari Stefansson, Nathan D Pankratz, Daniel E Bauer, Paul L Auer, Alex P Reiner Dec 2022

Whole Genome Sequencing Identifies Structural Variants Contributing To Hematologic Traits In The Nhlbi Topmed Program, Doruk Beyter, Caitlin P Mchugh, John Lane, Min-Zhi Jiang, Laura M Raffield, Goo Jun, Fritz J Sedlazeck, Ginger Metcalf, Yao Yao, Joshua B Bis, Nathalie Chami, Paul S De Vries, Pinkal Desai, James S Floyd, Yan Gao, Kai Kammers, Wonji Kim, Jee-Young Moon, Lisa R Yanek, Laura Almasy, Lewis C Becker, John Blangero, Michael H Cho, Joanne E Curran, Myriam Fornage, Robert C Kaplan, Joshua P Lewis, Ruth J F Loos, Braxton D Mitchell, Alanna C Morrison, Michael Preuss, Bruce M Psaty, Stephen S Rich, Jerome I Rotter, Hua Tang, Russell P Tracy, Eric Boerwinkle, Goncalo R Abecasis, Thomas W Blackwell, Albert V Smith, Andrew D Johnson, Rasika A Mathias, Deborah A Nickerson, Matthew P Conomos, Yun Li, Unnur Þorsteinsdóttir, Magnús K Magnússon, Kari Stefansson, Nathan D Pankratz, Daniel E Bauer, Paul L Auer, Alex P Reiner

Faculty, Staff and Student Publications

Genome-wide association studies have identified thousands of single nucleotide variants and small indels that contribute to variation in hematologic traits. While structural variants are known to cause rare blood or hematopoietic disorders, the genome-wide contribution of structural variants to quantitative blood cell trait variation is unknown. Here we utilized whole genome sequencing data in ancestrally diverse participants of the NHLBI Trans Omics for Precision Medicine program (N = 50,675) to detect structural variants associated with hematologic traits. Using single variant tests, we assessed the association of common and rare structural variants with red cell-, white cell-, and platelet-related quantitative traits …

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Description Of The Immature Stages Of Dacus Bivittatus (Diptera: Tephritidae), The Greater Pumpkin Fruit Fly, Gary J. Steck, Shepard Ndlela, Louis A. Somma, Jessica Diaz, Matthew R. Moore, Jessica Awad Dec 2022

Description Of The Immature Stages Of Dacus Bivittatus (Diptera: Tephritidae), The Greater Pumpkin Fruit Fly, Gary J. Steck, Shepard Ndlela, Louis A. Somma, Jessica Diaz, Matthew R. Moore, Jessica Awad

All Peer-Reviewed Publications

We describe the egg, three instars, and pupa of Dacus bivittatus Bigot using optical and scanning electron microscopy and compare them with those of other Dacus Fabricius species for which these stages have been described as well as those of two important pest species of Zeugodacus Hendel that infest cucurbits. A new anatomical term, lateral lips, is introduced to describe a feature of the facial mask. A feature of the egg that has not been reported previously for Tephritidae is described here: a peculiar arrangement of aeropyles in an irregular line partially encircling the egg near the posterior end. A …

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Integrative Revision Of Five Genera Type Species For Zoanthidea To Bridge The Parataxonomy Gap, Jacob Colbert Dec 2022

Integrative Revision Of Five Genera Type Species For Zoanthidea To Bridge The Parataxonomy Gap, Jacob Colbert

All HCAS Student Capstones, Theses, and Dissertations

Cnidarian order Zoanthidea is a relatively understudied group of invertebrates inhabiting a diverse range of marine habitats. Over/During the last two decades, species descriptions within this order have largely been based on a novel molecular parataxonomic system that relies almost exclusively on DNA barcodes to detect and describe new species. DNA barcodes are short, conserved sequences that are readily compared across taxa and used to detect previously described species. The existing taxonomic system, based on anatomical analysis and the identification of evolutionarily informative characters for phylogenetic inference, has been recently replaced by molecular parataxonomy by some scientists/researchers. While molecular sequence …

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Vertical And Diel Behavior Patterns Of Adult Lemon Sharks (Negaprion Brevirostris) Around The Southeastern Florida And Western Bahamas Coastal Shelves, Jacquelyne Reuder Dec 2022

Vertical And Diel Behavior Patterns Of Adult Lemon Sharks (Negaprion Brevirostris) Around The Southeastern Florida And Western Bahamas Coastal Shelves, Jacquelyne Reuder

All HCAS Student Capstones, Theses, and Dissertations

The lemon shark (Negaprion brevirostris) is a large sub-tropical species found in the western Atlantic Ocean from Virginia to Brazil, including The Bahamas and Caribbean Sea. Previous studies on habitat utilization were conducted on juveniles in The Bahamas, but little is known about vertical depth and temperature preferences of adults. Given the species’ risk to overexploitation and habitat degradation, the IUCN Red List recently listed lemon sharks as Vulnerable. Pop-up satellite archival tags (PSATs) were deployed on lemon sharks (n=7) in 2008 and 2009 off Jupiter, Florida (n=6; two females, four males) and Tiger Beach, Bahamas (n=1; one …

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Clinical Trial Development In Tp53-Mutated Locally Advanced And Recurrent And/Or Metastatic Head And Neck Squamous Cell Carcinoma, Cristina P Rodriguez, Hyunseok Kang, Jessica L Geiger, Barbara Burtness, Christine H Chung, Carole Fakhry, Sue S Yom, Thomas J Galloway, Erica Golemis, Alice Li, Jeffrey Shoop, Stuart Wong, Ranee Mehra, Heath Skinner, Nabil F Saba, Elsa R Flores, Jeffrey N Myers, James M Ford, Rachel Karchin, Robert L Ferris, Charles Kunos, Jean M Lynn, Shakun Malik Dec 2022

Clinical Trial Development In Tp53-Mutated Locally Advanced And Recurrent And/Or Metastatic Head And Neck Squamous Cell Carcinoma, Cristina P Rodriguez, Hyunseok Kang, Jessica L Geiger, Barbara Burtness, Christine H Chung, Carole Fakhry, Sue S Yom, Thomas J Galloway, Erica Golemis, Alice Li, Jeffrey Shoop, Stuart Wong, Ranee Mehra, Heath Skinner, Nabil F Saba, Elsa R Flores, Jeffrey N Myers, James M Ford, Rachel Karchin, Robert L Ferris, Charles Kunos, Jean M Lynn, Shakun Malik

Faculty, Staff and Student Publications

TP53 mutation is the most frequent genetic event in head and neck squamous cell carcinoma (HNSCC), found in more than 80% of patients with human papillomavirus-negative disease. As mutations in the TP53 gene are associated with worse outcomes in HNSCC, novel therapeutic approaches are needed for patients with TP53-mutated tumors. The National Cancer Institute sponsored a Clinical Trials Planning Meeting to address the issues of identifying and developing clinical trials for patients with TP53 mutations. Subcommittees, or breakout groups, were tasked with developing clinical studies in both the locally advanced and recurrent and/or metastatic (R/M) disease settings as well as …

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Potential Probiotic Properties Of Exopolysaccharide-Producing Lacticaseibacillus Paracasei Eps Da-Bacs And Prebiotic Activity Of Its Exopolysaccharide, Min-Gyu Lee, Huijin Joeng, Jaein Shin, Suin Kim, Chaeeun Lee, Byung-Hoo Lee, Tae-Ho Lee, Hai-Hua Jiang, Young-Sun Han, Bong-Gyeong Lee, Ho-Jin Lee, Min-Ju Park, Yun-Ju Jun, Young-Seo Park Dec 2022

Potential Probiotic Properties Of Exopolysaccharide-Producing Lacticaseibacillus Paracasei Eps Da-Bacs And Prebiotic Activity Of Its Exopolysaccharide, Min-Gyu Lee, Huijin Joeng, Jaein Shin, Suin Kim, Chaeeun Lee, Byung-Hoo Lee, Tae-Ho Lee, Hai-Hua Jiang, Young-Sun Han, Bong-Gyeong Lee, Ho-Jin Lee, Min-Ju Park, Yun-Ju Jun, Young-Seo Park

Faculty, Staff and Student Publications

Exopolysaccharide (EPS)-producing Lacticaseibacillus paracasei EPS DA-BACS was isolated from healthy human feces and its probiotic properties, as well as the structure and prebiotic activity of the EPS from this strain were examined. EPS from L. paracasei EPS DA-BACS had a ropy phenotype, which is known to have potential health benefits and is identified as loosely cell-bounded glucomannan-type EPS with a molecular size of 3.7 × 106 Da. EPS promoted the acid tolerance of L. paracasei EPS DA-BACS and provided cells with tolerance to gastrointestinal stress. The purified EPS showed growth inhibitory activity against Clostridium difficile. L. paracasei EPS DA-BACS cells …

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The Time Is Right For An Antarctic Biorepository Network, Kristin M. O’Brien, Elizabeth L. Crockett, Bryon J. Adams, Charles D. Amsler, Hannah J. Appiah-Madson, Allen Collins, Thomas Desvignes, Sarah Eppley, Multiple Additional Authors Dec 2022

The Time Is Right For An Antarctic Biorepository Network, Kristin M. O’Brien, Elizabeth L. Crockett, Bryon J. Adams, Charles D. Amsler, Hannah J. Appiah-Madson, Allen Collins, Thomas Desvignes, Sarah Eppley, Multiple Additional Authors

Biology Faculty Publications and Presentations

Antarctica is a central driver of the Earth’s climate and health. The Southern Ocean surrounding Antarctica serves as a major sink for anthropogenic CO2 and heat (1), and the loss of Antarctic ice sheets contributes significantly to sea level rise and will continue to do so as the loss of ice sheets accelerates, with sufficient water stores to raise sea levels by 58 m (2). Antarctica's marine environment is home to a number of iconic species, and the terrestrial realm harbors a remarkable oasis for life, much of which has yet to be discovered (3). Distinctive oceanographic features of the …

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Near Infrared Spectroscopy Is Not A Surrogate Of Venous Occlusion Plethysmography To Assess Microvascular Resting Blood Flow And Function, Manuel Gomez, Alvaro N. Gurovich, Samuel Montalvo Dec 2022

Near Infrared Spectroscopy Is Not A Surrogate Of Venous Occlusion Plethysmography To Assess Microvascular Resting Blood Flow And Function, Manuel Gomez, Alvaro N. Gurovich, Samuel Montalvo

International Journal of Exercise Science

International Journal of Exercise Science 15(2): 1616-1626, 2022. Near-infrared spectroscopy (NIRS) is a non-invasive technique that measures tissue perfusion using red blood cells oxygen saturation and venous occlusion plethysmography (VOP) is the gold standard to assess microvascular blood flow and function. The purpose of this study was to determine if NIRS can surrogate the microvascular blood flow assessment after an ischemic challenge obtained via VOP. Twenty apparently healthy subjects (10 males and 10 females), aged 18 to 35 years, were recruited for this single session study. NIRS probes were placed 40mm apart along the epicondylar muscles on the right forearm …

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Worldwide Distribution Of Cave-Dwelling Chelodesmidae (Diplopoda, Polydesmida), Rodrigo Salvador Bouzan, Jackson C. Means, Kaloyan Ivanov, Rodrigo L. Ferreira, Antonio Domingos Brescovit, Luiz Felipe Moretti Iniesta Dec 2022

Worldwide Distribution Of Cave-Dwelling Chelodesmidae (Diplopoda, Polydesmida), Rodrigo Salvador Bouzan, Jackson C. Means, Kaloyan Ivanov, Rodrigo L. Ferreira, Antonio Domingos Brescovit, Luiz Felipe Moretti Iniesta

International Journal of Speleology

Chelodesmidae is one of the most species rich families within the Myriapoda. However, little is known regarding their association with caves. We provide a list of all Chelodesmidae taxa reported from caves, map their worldwide distribution, and discuss the troglomorphic features of the group. A total of 25 species and subspecies from 20 genera and 2 subfamilies have been recorded from 59 caves and cave systems in 11 countries. These numbers represent a surprisingly modest proportion (~3%) of the approximately 800 described species in the family. Records of cave-dwelling chelodesmids appear to be geographically biased with most taxa reported from …

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Genetic Variation Among Populations Of, And Evidence Of Deep Divergence Within, The Rio Grande Chirping Frog, Eleutherodactylus Campi (Anura: Eleutherodactylidae), Kebede Beshera, Avery A. Williams Mr., John A. Hamlin Dr., Peter J. Bergeaux Mr., Christian C. Morgan Dr., Aubrey N. Armstrong Ms. Dec 2022

Genetic Variation Among Populations Of, And Evidence Of Deep Divergence Within, The Rio Grande Chirping Frog, Eleutherodactylus Campi (Anura: Eleutherodactylidae), Kebede Beshera, Avery A. Williams Mr., John A. Hamlin Dr., Peter J. Bergeaux Mr., Christian C. Morgan Dr., Aubrey N. Armstrong Ms.

Faculty Publications

Herein we report the first molecular assessment of intra-species genetic variation and interrelationships within the Rio Grande Chirping frog, Eleutherodactylus campi. We analyzed 548 base pairs of 16S rRNA gene for 71 ingroup individuals belonging to the genus Eleutherodactylus (including 42 E. campi sampled from 15 localities in the United States and Mexico) and four outgroup samples. By unveiling two highly divergent and geographically structured clades within E. campi this study provides a novel phylogenetic placement of E. campi populations north and south of the Rio Grande Valley as sister groups to each other. The observed level of genetic …

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A Helping Hand Through Dying Light, Jason Moessing Dec 2022

A Helping Hand Through Dying Light, Jason Moessing

Fall Student Research Symposium 2022

Many people go into martial relationships with a previous history of childhood maltreatment. This can cause marital problems later on in the marriage if steps are not taken to help the individual heal from the abuse. To find relevant information to help in this understanding, a diverse amount of websites were researched including blogs, scholarly articles, data observations, and therapy websites. Past history of childhood maltreatment can cause lasting problems in marriages, but when couples decide to find help those marriages can become beautiful symbols of love. Men and women have been found to react differently to different types of …

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The Effects Of Raising A Child With Companion Animals, Abby Murcray Dec 2022

The Effects Of Raising A Child With Companion Animals, Abby Murcray

Fall Student Research Symposium 2022

What were the effects on children who were raised with companion animals? As someone who has grown up with companion animals most of my life, I wanted to learn what impact the animals had on my growth and development. The research was conducted using library and internet resources to locate both primary and secondary resources. For this study, I looked at specific studies done on children that are surrounded by companion animals versus those that are not, using mostly Utah State's Academic Search Ultimate to find my sources. Raising a child with a domestic animal benefits a child in many …

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Pseudo-Embryology And Personhood: How Embryological Pseudoscience Helps Structure The American Abortion Debate, Scott F. Gilbert Dec 2022

Pseudo-Embryology And Personhood: How Embryological Pseudoscience Helps Structure The American Abortion Debate, Scott F. Gilbert

Biology Faculty Works

There is a pseudo-embryology flourishing today, well nourished by popular science, religious ideologies, and the public media. Just as eugenics was a pseudoscience that influenced (and still influences) American popular culture and which was responsible for racist anti-immigration laws (such as the Immigration Restriction Act of 1924), pseudo-embryology is also influencing popular culture and legislation. This new pseudoscience promotes the belief that science supports current zygotic and fetal personhood movements as well as anti-abortion legislation. However, what often passes for science are actually ideological myths, often grounded in and supporting male superiority. Indeed, the first myth of pseudo-embryology is that …

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Motivation Toward Sport, Physical Activity And Exercise Between College Students In Hungary And The United States During Covid-19, Whitney Gene Davies Dec 2022

Motivation Toward Sport, Physical Activity And Exercise Between College Students In Hungary And The United States During Covid-19, Whitney Gene Davies

Theses and Dissertations

During the COVID-19 pandemic many researchers noted changes in exercise, physical activity, and sports behaviors. The current study attempts to identify aspects of motivation for physical activity, exercise, and sport for students in two countries, the USA and Hungary. The current study used the Sports Motivation Scale II to measure students’ motivation based on the Self-Determination Theory. Results indicated that students in the USA were more motivated for exercise, physical activity, and sport during the COVID-19 pandemic than were their Hungarian counterparts. Students in the United States scored higher (MUS = 17.88) in overall motivation than their Hungarian counterparts (MHungary …

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An Examination Of The Associations Between Relationship Education, Trust, Communication, Relationship Satisfaction, And Sexual Satisfaction, Samantha Baker Dec 2022

An Examination Of The Associations Between Relationship Education, Trust, Communication, Relationship Satisfaction, And Sexual Satisfaction, Samantha Baker

Undergraduate Honors Theses

Relationship education courses are commonly used by couples seeking to increase their relationship and sexual satisfaction. In this study, I examined the mediating roles of trust and communication between marriage education classes and relationship and sexual satisfaction. This study used data from the Couple Relationships and Transition Experiences (CREATE) study, a longitudinal, nationally representative survey of newlywed couples. While the present study did not find a significant relationship between marriage preparation and relationship and sexual satisfaction, it does not rule out the possibility of a relationship existing due to some limitations of the present study. This study did find significant …

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Development Of Adaptive Rice Variety To Non-Tidal Swamp: Growth Evaluation Of Backcrossed Progenies (Bc1f1) And Its Parents, Inpago 5 And Inpara 8, Nabilah Amiros, Rujito Agus Suwignyo, Mery Hasmeda, Fikri Adriansyah, Entis Sutisna Halimi, Erizal Sodikin Dec 2022

Development Of Adaptive Rice Variety To Non-Tidal Swamp: Growth Evaluation Of Backcrossed Progenies (Bc1f1) And Its Parents, Inpago 5 And Inpara 8, Nabilah Amiros, Rujito Agus Suwignyo, Mery Hasmeda, Fikri Adriansyah, Entis Sutisna Halimi, Erizal Sodikin

Jurnal Kultivasi

Rice (Oryza sativa L.) cultivation in non-tidal swamp is severely constrained by abiotic stresses, i.e., submerged stress in the vegetative phase and drought stress in the generative phase. The development of rice varieties that have dual-tolerant to those abiotic stresses can improve adaptability and increase productivity. Efforts to obtain adaptive varieties under those abiotic stress conditions are being carried out by selecting the parents and crossing them, and has resulted in the population of BC1F1. The research was carried out on April – June 2021 at greenhouse of the Agriculture Faculty, Sriwijaya University. The study aimed to evaluate the growth …

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A Review Of The Role Of Pollination On The Yield Of Cocoa Plant, Dani, Dewi Nur Rokhmah Dec 2022

A Review Of The Role Of Pollination On The Yield Of Cocoa Plant, Dani, Dewi Nur Rokhmah

Jurnal Kultivasi

Yield of cocoa (Theobroma cacao L.) plant, in form of cocoa seeds, is produced through the process of sexual reproduction. Pollination plays an important role in the successful formation of cocoa fruit and seeds. In addition, number of ovules per ovary, degree of self-incompatibility, and xenia effect are also affected the final yield. Those characters are determined by genetic factors. Cocoa flowers that are not pollinated fall within 24 hours and fail to develop into fruits and seeds. Pollination intensity up to a certain level showed a significant effect on increasing the percentage of fruit formation and the number of …

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Application Of Legume Cover Crop And Various Vermicompost Dosages On Young Cinchona In The Marginal Area, Yudithia Maxiselly, Mira Ariyanti, Mochamad Arief Soleh, Naufal Fikri Dec 2022

Application Of Legume Cover Crop And Various Vermicompost Dosages On Young Cinchona In The Marginal Area, Yudithia Maxiselly, Mira Ariyanti, Mochamad Arief Soleh, Naufal Fikri

Jurnal Kultivasi

Cinchona (Cinchona ledgeriana Moens) is one of the important medicinal plants that have the potential to cultivate as herbal medicine. This plant grows well in highland areas. Developing cinchona plants in the marginal area needs effort and modification techniques such as planting legume cover crop (LCC) to maintain the humidity and supply nutrition by fertilizing. Vermicompost is one of the organic fertilizers with rich nutrition to support plant growth. This research aimed to observe the effect of a combination of Mucuna bracteata as LCC and vermicompost dosage on young cinchona growth in a marginal area. This research was carried out …

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Smokejumper Obituary: Owen, David L. “Dave” (Missoula 1951), National Smokejumper Association Dec 2022

Smokejumper Obituary: Owen, David L. “Dave” (Missoula 1951), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

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Standardization Of A Latent Blood Visualizer Based Upon Dna Degradation, Kailey M. Van 'T Hoff Dec 2022

Standardization Of A Latent Blood Visualizer Based Upon Dna Degradation, Kailey M. Van 'T Hoff

Honors Projects

Latent blood visualizers have been used in forensic science since 1937 beginning with Luminol. These visualizers through different types of reactions react with trace amounts of blood that cannot be seen with the naked human eye. These different reactions produce color that can then be seen by examiners. The four types of latent blood visualizers that were compared is luminol, leuco crystal violet, fluorescein, and bluestar. Luminol and bluestar use chemiluminescence, fluorescein uses florescent, and leuco crystal violet uses oxidation to react with iron in hemoglobin. At crime scenes when blood is detected which includes with the blood visualizers the …

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Screening Anti-Pd-L2 Peptides As Antitumor Ligands Using Phage Display, Chien Tran Phuoc Dec 2022

Screening Anti-Pd-L2 Peptides As Antitumor Ligands Using Phage Display, Chien Tran Phuoc

Honors Projects

Cancer still remains one of the top leading causes of death in America. Recently, programmed cell death protein 1 (PD-1) blockades have been demonstrated to be highly effective against various types of cancer. By blocking PD-1 from binding with their ligands (PD-L1 and PD-L2), the “off” signal to the immune system is inhibited, hence reinvigorating the immune cells to kill tumor cells. To date, despite PD-L1 and PD-L2 both interacting with PD-1, research efforts have only been focused on developing anti-PD-L1 inhibitors. Therefore, the work of this honor project has focused on finding anti-PD-L2 peptides by phage display, with the …

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Cpg Site-Based Signature Predicts Survival Of Colorectal Cancer, Jiande Wu, Lu Zhang, Aditi Kuchi, David Otohinoyi, Chindo Hicks Dec 2022

Cpg Site-Based Signature Predicts Survival Of Colorectal Cancer, Jiande Wu, Lu Zhang, Aditi Kuchi, David Otohinoyi, Chindo Hicks

School of Medicine Faculty Publications

Background: A critical unmet medical need in clinical management of colorectal cancer (CRC) pivots around lack of noninvasive and or minimally invasive techniques for early diagnosis and prognostic prediction of clinical outcomes. Because DNA methylation can capture the regulatory landscape of tumors and can be measured in body fluids, it provides unparalleled opportunities for the discovery of early diagnostic and prognostics markers predictive of clinical outcomes. Here we investigated use of DNA methylation for the discovery of potential clinically actionable diagnostic and prognostic markers for predicting survival in CRC. Methods: We analyzed DNA methylation patterns between tumor and control samples …

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Overexpression Of Sox18 Increased Cell Proliferation, Migration And Colony Formation In Pediatric Sarcomas, Jack E. Ojile Dec 2022

Overexpression Of Sox18 Increased Cell Proliferation, Migration And Colony Formation In Pediatric Sarcomas, Jack E. Ojile

Honors Program Theses and Research Projects

Cancer has become one of the leading causes for premature deaths and continues to increase in rank across the world. An estimated 19.3 million new cases of cancer were reported in 2020 and 10 million cancer related deaths occurred worldwide. Ewing sarcoma and Rhabdomyosarcoma are two pediatric cancers that have not made significant improvements to patient survival for a metastatic diagnosis and the current chemotherapy regiment can cause several undesirable side effects immediately after treatment or later in life. SOX18 has been observed to play some role in various tumorigenic properties like proliferation, invasion, and resisting cell death signals in …

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The Use Of Inertial Measurement Unit For The Characterization Of Multiple Functional Movement Patterns In Individuals With Chronic Ankle Instability, Seunguk Han Dec 2022

The Use Of Inertial Measurement Unit For The Characterization Of Multiple Functional Movement Patterns In Individuals With Chronic Ankle Instability, Seunguk Han

Theses and Dissertations

Patients with a history of lateral ankle sprain (LAS) may experience different levels of mechanical and/or sensorimotor deficits following their injuries. Although various factors, such as structural damage, sensorimotor adaptation, perceived instability, swelling and/or pain, can develop and perpetuate the condition of chronic ankle instability (CAI), most previous CAI research on biomechanics has considered all patients with CAI as a homogeneous group. Recent research has clustered patients with CAI into six distinct movement patterns during a maximal jump-landing/cutting task. This approach could motivate clinicians to develop appropriate rehabilitation programs for each patient with CAI depending on their movement patterns. However, …

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Application Of Organic Fertilizer And Phosphate Solubilizing Bacteria To Increase The Growth And Yield Of Potatoes In Andisol, Agustina Erlinda Marpaung, Bina Karo, Susilawati Barus, Rina Christina Hutabarat, Rasiska Tarigan Dec 2022

Application Of Organic Fertilizer And Phosphate Solubilizing Bacteria To Increase The Growth And Yield Of Potatoes In Andisol, Agustina Erlinda Marpaung, Bina Karo, Susilawati Barus, Rina Christina Hutabarat, Rasiska Tarigan

Jurnal Kultivasi

Andisol has low phosphate (P) nutrient content due to high P fixation by allophane minerals, which affects crop production. The application of organic fertilizers and phosphate solubilizing bacteria can increase the availability of P in the soil in order to increase the production of potato plants. This study aimed to evaluate the effect of different types of organic fertilizer and phosphate solubilizing bacteria (PSB) on potato production. The research was conducted from August to November 2020 in the installation of research and assessment of agricultural technology Berastagi, Karo Regency, with an altitude of ± 1,340 m above sea level and …

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Quantifying The Toxicological Effects Of The Organic Uv Filters Avobenzone And Homosalate On Acropora Cervicornis, Samantha F. Buckley Dec 2022

Quantifying The Toxicological Effects Of The Organic Uv Filters Avobenzone And Homosalate On Acropora Cervicornis, Samantha F. Buckley

All HCAS Student Capstones, Theses, and Dissertations

Reports of the environmental effects of organic UV filters such as oxybenzone have led to the marketing of “reef-safe” sunscreen ingredients, including avobenzone and homosalate. Avobenzone provides broad-spectrum UV protection which blocks higher wavelength UV rays, the leading cause of aging and skin cancer. However, as polycyclic aromatic hydrocarbons (PAHs), organic UV filters have similar structures to crude oil and estrogens, some of which have been labeled endocrine disrupters. Common in personal care products, UV filters enter marine ecosystems via wastewater effluent and swimmers. Significant stress and mortality have been observed in juvenile and some adult scleractinian corals after exposure …

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Toxicity And Effectiveness Of A New Two-Part Underwater Adhesive For Coral Restoration, Matthew Rojano Dec 2022

Toxicity And Effectiveness Of A New Two-Part Underwater Adhesive For Coral Restoration, Matthew Rojano

All HCAS Student Capstones, Theses, and Dissertations

As coral cover decreases around the world due to disease, bleaching events, and anthropogenic effects, coral restoration projects become increasingly important. A crucial part of many coral restoration projects is the attachment of corals to substrates in nurseries or reef substrates during outplanting. The effective anchoring of transplants is a critical phase in coral restoration and the adhesive used for attachment is crucial. Commonly used adhesives have several drawbacks: there are long mixing times, low substrate adhesion, and lengthy hardening times. To address these issues and provide an effective alternative for coral restoration activities, a new two-part Mixed Adhesive was …

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