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Articles 45121 - 45150 of 255951

Full-Text Articles in Life Sciences

A Cladoxylopsid With Complex Vascular Architecture From The Early Devonian Battery Point Formation (Québec, Canada), Jessica Chu Jan 2023

A Cladoxylopsid With Complex Vascular Architecture From The Early Devonian Battery Point Formation (Québec, Canada), Jessica Chu

Cal Poly Humboldt theses and projects

Cladoxylopsids are seed-free plants that formed the world’s earliest forests and gave rise to horsetails (sphenopsids), but their evolutionary origins are poorly understood. Here, I describe a new Early Devonian cladoxylopsid from the Emsian (400-395 Ma) Battery Point Formation (Québec, Canada). The structural features of this plant indicate taxonomic affinity to cladoxylalean cladoxylopsids and its phylogenetic position supports placement in genus Cladoxylon (the proposed name, Cladoxylon kespekianum sp. nov., to be formalized by peer-reviewed publication). Specimens of this plant are permineralized in calcium carbonate and were studied using the acetate peel technique with light and electron microscopy. Cladoxylon kespekianum is …

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Botanical Updates From Psu, Gabriel Campbell Jan 2023

Botanical Updates From Psu, Gabriel Campbell

Rae Selling Berry Seed Bank and Plant Conservation Program

These slides summarize the botanical work conducted at PSU in 2022.

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Is Growth Hormone The Fountain Of Youth?, David Youlus Jan 2023

Is Growth Hormone The Fountain Of Youth?, David Youlus

The Science Journal of the Lander College of Arts and Sciences

Finding the cure for aging has been a sought-after quest for as long as the world has existed. Growth hormone has been shown as a possible treatment to negate the phenotypic effects of aging. Growth hormone is released from the adenohypophysis in response to sleep, exercise and stress. This in turn stimulates insulin-like growth factor-1 (IGF-1) secretion from the liver. Growth hormone circulation decreases in volume during aging. Studies on growth hormone therapy have indicated youth-like benefits, such as the reversal of sarcopenia, improved cognitive function, and boosted immunity. However, creating an imbalance of growth hormone and insulin-like factor-1 also …

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Differences In The Neurological Pathways Of Innate And Learned Fear, Efrat Jacob Jan 2023

Differences In The Neurological Pathways Of Innate And Learned Fear, Efrat Jacob

The Science Journal of the Lander College of Arts and Sciences

Fear is a fundamental emotion for survival. However, not all fears are the same, leading to a necessary distinction between the two main subsections of fear; innate and learned. This research paper investigates whether the neural pathways underlying innate and learned fear are independent of each other. Using optogenetics and pharmacology, researchers have manipulated specific brain regions and circuits involved in fear processing, such as the amygdala, hypothalamus, and PAG (periaqueductal gray). By measuring the behavioral and physiological indicators of fear in rodents exposed to different types of stimuli, research suggests that there may be partial overlap between the neural …

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Spartina Species Invasive In Coastal Salt Marshes And Mudflats Of The Pacific Northwest, Gabriel E. Campbell, Ashley Newcomb, Jacob Rose Jan 2023

Spartina Species Invasive In Coastal Salt Marshes And Mudflats Of The Pacific Northwest, Gabriel E. Campbell, Ashley Newcomb, Jacob Rose

Center for Lakes and Reservoirs Publications and Presentations

Spartina (cordgrass) species are invasive plants that threaten the Pacific Northwest of the United States of America. This document contains a literature review, map of known occurrences, and identification guide of Spartina species invasive in coastal salt marshes and mudflats of the Pacific Northwest.

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Aquatic Invasive Species Survey And Treatment On Lake Umatilla And Lake Celilo 2022-2023 Report, Gabriel E. Campbell, Jacob Rose Jan 2023

Aquatic Invasive Species Survey And Treatment On Lake Umatilla And Lake Celilo 2022-2023 Report, Gabriel E. Campbell, Jacob Rose

Center for Lakes and Reservoirs Publications and Presentations

Flowering Rush (Butomus umbellatus) is an invasive aquatic plant in the Pacific Northwest that threatens salmon habitat. The Center for Lakes and Reservoirs staff surveyed for this and other aquatic species from 2022 and 2023 in the Columbia River in Lake Umatilla and Lake Celilo. This document summarizes their survey efforts including their protocols, data, and small-scale removal efforts.

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Contrast Of Smokeless Tobacco And It's Microbiological Footprint In Users And Non-Users, Monayjia Brown, Katie Robbins, Elyse Mckinney, Sydney Snell Jan 2023

Contrast Of Smokeless Tobacco And It's Microbiological Footprint In Users And Non-Users, Monayjia Brown, Katie Robbins, Elyse Mckinney, Sydney Snell

Humboldt Journal of Microbiology

Smokeless tobacco products such as vapes have gained significant popularity over the last 20 years (7), and it is clear that the effects of these products are primarily unknown. This study examines how the microbial profiles found in smokeless tobacco products, such as vapes, can be used in forensic science. By linking these profiles to their owners, investigators can identify suspects in cases where traditional evidence is lacking. This information could provide valuable assistance in tracking victims and matching perpetrators or victims to crime scenes. Forensic science involves any evidence found at a crime scene that is examined and analyzed …

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Preclinical Study On Hepatoprotective Potential And Antioxidant Status Analysis Of The Fruit Extract Of Rivina Humilis L. (Red Pigeon Berry) In Rats, Raju Asirvatham, Dinu George, P. A. Daisy, Dawn V. Tomy, G. Boby Johns Jan 2023

Preclinical Study On Hepatoprotective Potential And Antioxidant Status Analysis Of The Fruit Extract Of Rivina Humilis L. (Red Pigeon Berry) In Rats, Raju Asirvatham, Dinu George, P. A. Daisy, Dawn V. Tomy, G. Boby Johns

The Thai Journal of Pharmaceutical Sciences

Hepatoprotective and antioxidant potential of hydromethanolic extract of Rivina humilis L. fruit (HMERH) was studied using the carbon tetrachloride (CCl4) and paracetamol (PCM) induced hepatotoxicity in Wistar rats. In both models, rats were divided into five groups having six rats in each. Group I received distilled water. Group II, disease control, Group III received 100 mg/kg of Silymarin. Group IV and Group V received 500, 1000 mg/kg of HMERH. All groups except Group II received treatment twice daily for 7 days. CCl4 (1.5 mL/kg, PCM (2 g/kg), p.o) were administered after the last dose. The degree of liver protection against …

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Development Of A Thai Pharmacists’ Cultural Competency Self-Assessment Scale, Auttakrit Aunkaew, Puckwipa Suwannaprom, Siritree Suttajit Jan 2023

Development Of A Thai Pharmacists’ Cultural Competency Self-Assessment Scale, Auttakrit Aunkaew, Puckwipa Suwannaprom, Siritree Suttajit

The Thai Journal of Pharmaceutical Sciences

Objective: The objective of the study was to develop and evaluate a cultural competency assessment form for Thai pharmacists. Materials and Methods: The research was conducted in two phases. Phase 1 involved item development based on the Campinha-Bacote’s and the ACPP’s concept of cultural competency and the self-assessment of perceived level of cultural competence questionnaire. Seven experts assessed the content validity and face validity. The revised scale was tested for comprehension among 12 pharmacists using the think-aloud technique. Phase 2 constituted the scale development and scale evaluation. The Thai pharmacist cultural competency self-assessment (TPCCS) scale developed from Phase I was …

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Wood And Leaf Remains Of Palms With Affinities To Sabal Adans., From The Middle Eocene Of Turkey, Ünal Akkemi̇k, Stanila Iamandei, Euginia Iamandei, Fi̇kret Koçbulut, Hüseyi̇n Tuncay Güner, Hakan Çeli̇k, Umut Tunç Jan 2023

Wood And Leaf Remains Of Palms With Affinities To Sabal Adans., From The Middle Eocene Of Turkey, Ünal Akkemi̇k, Stanila Iamandei, Euginia Iamandei, Fi̇kret Koçbulut, Hüseyi̇n Tuncay Güner, Hakan Çeli̇k, Umut Tunç

Turkish Journal of Botany

Two new fossil species based on the study of wood remains and leaf imprints from the middle Eocene Çekerek Formation (central-northern part of Turkey) are assigned to the palm family Arecaceae. Standard thin sections from the two samples of fossil wood were investigated and identified as Palmoxylon sabaloides Greguss 1969, with close xylotomical affinities to the modern genus Sabal Adans. The leaf imprints are weakly costapalmate and correspond to the genus Sabal as well. Based on the short petiole extension (costa), the leaves resemble the fossil-species Sabal lamanonis (Brongn.) Heer, 1855. This fossil-species was abundant in Paleogene strata of western …

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Understanding The Development Of Rafflesia Using A Transcriptomic Study Of Seed And Flower Bud In Comparison To Arabidopsis Thaliana, Brian Joseph Tomek Jan 2023

Understanding The Development Of Rafflesia Using A Transcriptomic Study Of Seed And Flower Bud In Comparison To Arabidopsis Thaliana, Brian Joseph Tomek

Selected Full-Text Master Theses 2021-

The holoparasitic plant genus Rafflesia is of interest for producing the largest single flowers in the world, though efforts to conserve it have been challenging with not much success in ex situ propagation due to the little that we know of its biology. Further study and understanding of the growth of Rafflesia species is necessary in order to preserve these endangered plants. Due to its potentially long growth cycle, there is a definite difficulty in studying the growth cycle through observation alone. Transcriptomic study is one tool which can be used to understand how Rafflesia species change throughout different stages …

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Exploring Ph Gradient Phenomena In Non-Linear Electrokinetic Microfluidic Devices, Azade Tahmasebi Jan 2023

Exploring Ph Gradient Phenomena In Non-Linear Electrokinetic Microfluidic Devices, Azade Tahmasebi

Dissertations, Master's Theses and Master's Reports

Electrokinetic microfluidics is a versatile technology utilized within lab on a chip (LOC) devices for diagnostic and analytical applications; advantages include reduced resource demands, flexibility, and simplicity of use. Dielectrophoresis (DEP) is a precision nonlinear electrokinetic tool utilized within microfluidic microdevices to induce polarization and control bioparticle motions for applications that range from hemoglobin separations to cancer cell isolation and detection. Despite promising results, undesired side phenomena can occur in electrokinetic systems which impede reproducibility and accuracy. These unfavorable phenomena have not been comprehensively explored in the literature. Prior preliminary research suggests the fundamental phenomena originate from microelectrodes utilized in …

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Under Ice Photosynthetic Primary Production And Dark Carbon Fixation In A Temperate Freshwater System, Vanessa Cubillos Tellez Jan 2023

Under Ice Photosynthetic Primary Production And Dark Carbon Fixation In A Temperate Freshwater System, Vanessa Cubillos Tellez

Dissertations, Master's Theses and Master's Reports

Ice-covered lakes are vulnerable to environmental change, especially those in the Northern Hemisphere where ice cover is rapidly declining due to global warming. These changes can alter metabolic processes and disrupt carbon cycling driven by primary producers who form the base of the food chain and are key to sustaining ecosystem function. Photosynthetic primary production and dark carbon fixation under the ice in the Keweenaw Waterway, a temperate freshwater system that is ice-covered for ~3 months out of the year, were studied using a carbon isotopic labeling (14C-bicarbonate) technique. Water samples were collected weekly during ice cover and monthly during …

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Dissecting The Role Of Selenoprotein P And Thioredoxin Reductase In Pancreatic Cancer Metabolism, Alyssa A. Abbas Jan 2023

Dissecting The Role Of Selenoprotein P And Thioredoxin Reductase In Pancreatic Cancer Metabolism, Alyssa A. Abbas

Dissertations, Master's Theses and Master's Reports

Pancreatic ductal adenocarcinoma (PDAC), the fourth leading cause of US cancer-related deaths, has a stark 5-year survival rate of 9%, emphasizing an urgent need for effective therapies. A well-established characteristic of cancer, metabolic dysregulation, presents an opportunity for developing therapies that target specific metabolic susceptibilities inherent in cancer cells. Our recent studies have discovered a susceptibility in PDAC; deprivation of cystine or blocking its uptake by erastin (a cystine transport inhibitor) triggers significant lipid peroxidation, thereby inducing ferroptosis specifically in the mesenchymal subtype of PDAC, but not in the epithelial subtype. This study aims to elucidate the roles of Selenoprotein …

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Pharmacological Evaluation Of The Antirheumatic Activity Of Callicarpa Macrophylla Leaves Extracts By The Estimation Of Hepatic, Renal, And Inflammatory Markers, Harjinder Kaur, Ganesh N. Sharma, Mayur Bhurat Jan 2023

Pharmacological Evaluation Of The Antirheumatic Activity Of Callicarpa Macrophylla Leaves Extracts By The Estimation Of Hepatic, Renal, And Inflammatory Markers, Harjinder Kaur, Ganesh N. Sharma, Mayur Bhurat

The Thai Journal of Pharmaceutical Sciences

Background: Callicarpa macrophylla is used in traditional medicine to treat many disorders including analgesic, antipyretic and anti-inflammatory. The aim of this study is to investigate the ethanolic and ethylacetate extracts of C. macrophylla leaves against rheumatoid arthritis (RA). Materials and Methods: Acute toxicity was studied in vivo to determine the toxic doses of the ethanolic and ethyl acetate extracts. Anti-rheumatic activity was also evaluated in vivo using formaldehyde and Complete Freund’s Adjuvant models in Wistar rats. After that paw volume was evaluated by the digital Vernier caliper and blood sample was taken by retro-orbital plexus route for the estimation of …

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Ascorbic Acid-Loaded Poly(Lactic-Co-Glycolic Acid) Nanoparticles Incorporated Into A Polyacrylic Acid Gel As A Promising Tool For Site-Specific Oral Cancer Therapy, Nurul Ain Mohammad Hamdi, Ahmad Fahmi Harun Ismail, Muhammad Salahuddin, Widya Lestari Jan 2023

Ascorbic Acid-Loaded Poly(Lactic-Co-Glycolic Acid) Nanoparticles Incorporated Into A Polyacrylic Acid Gel As A Promising Tool For Site-Specific Oral Cancer Therapy, Nurul Ain Mohammad Hamdi, Ahmad Fahmi Harun Ismail, Muhammad Salahuddin, Widya Lestari

The Thai Journal of Pharmaceutical Sciences

Background: Chemotherapy is commonly used in oral cancer therapy, especially as the disease advances. However, it is associated with terrible adverse effects and the occurrence of chemoresistance which causes treatment failure. Thus, discovering a new potential anticancer agent and developing a safe, effective, and non-invasive drug delivery are necessary. Objective: The objective of the current study is to develop ascorbic acid-loaded poly(lactic-co-glycolic) acid (AA-PLGA) nanoparticles incorporated into polyacrylic acid gel intended to treat oral cancer. Materials and methods: Double emulsion solvent evaporation method was used to fabricate AA-PLGA nanoparticles. Optimization was carried out in the primary emulsion based on multilevel …

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Vegetable Oil-Based Cannabis: Its Cannabinoid Profiling And Photoprotective Effect On Uva-Irradiated Human Skin Keratinocytes, Nur Alfan Muhammad Zen, Kwanlada Kobtrakul, Petlada Khositanon, Kittipong Sanookpan, Visarut Buranasudja, Sornkanok Vimolmangkang Jan 2023

Vegetable Oil-Based Cannabis: Its Cannabinoid Profiling And Photoprotective Effect On Uva-Irradiated Human Skin Keratinocytes, Nur Alfan Muhammad Zen, Kwanlada Kobtrakul, Petlada Khositanon, Kittipong Sanookpan, Visarut Buranasudja, Sornkanok Vimolmangkang

The Thai Journal of Pharmaceutical Sciences

Vegetable oils serve as affordable, non-toxic, and eco-friendly solvents for plant extraction. Chemical fingerprinting shows that vegetable oil-based cannabis has a cannabinoid profile similar to that of organic solvent-based cannabis. All samples possess antioxidative effects as they contain several cannabinoids and other unidentified compounds, with rice bran oil-based sample exhibiting the strongest effect. Tetrahydrocannabinol (THC) and cannabidiol (CBD) content in sesame oil-based and perilla seed oil-based cannabis differed significantly from that in virgin coconut oil (VCO)-based cannabis. In addition, THC and CBD content in all vegetable oil-based samples prepared using the heating and frying method differed significantly from that in …

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Multi-Chamber Silencer Composed Of Screw-Perforated Tubes And Straight-Perforated Tubes, Tian-Syung Lan, Min-Chie Chiu Jan 2023

Multi-Chamber Silencer Composed Of Screw-Perforated Tubes And Straight-Perforated Tubes, Tian-Syung Lan, Min-Chie Chiu

Journal of Marine Science and Technology–Taiwan

The use of silencers to reduce noise is mandatory due to severe hearing damage caused by high venting noise in the engine room of ocean-going vessels. While straight and perforated tubes have been used as acoustical elements in traditional silencer design, studies have shown that the acoustical design still requires improvement. To enhance acoustical efficiency, the use of multi-chamber mufflers is proposed composed of screw and perforated tubes. Additionally, a mathematical finite element model built for acoustical simulation using the COMSOL program expedites the analysis of silencers with complicated acoustical elements. A sensitivity analysis of transmission loss concerning the geometric …

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Rapid Species Identification Of Meretrix Lusoria And Three Other Meretrix Clams Using Pcr And Rflp Analysis Of The Mitochondrial Coii Gene., Chia-Hsuan Sung, Liang-Jong Wang, Chang-Wen Huang Jan 2023

Rapid Species Identification Of Meretrix Lusoria And Three Other Meretrix Clams Using Pcr And Rflp Analysis Of The Mitochondrial Coii Gene., Chia-Hsuan Sung, Liang-Jong Wang, Chang-Wen Huang

Journal of Marine Science and Technology–Taiwan

Meretrix clams are among the most economically important species of bivalves in Eastern Asia and Taiwan. In the past, the identification of these hard clams depended on the shell morphology; however, species identification based on shell markings and shapes confuses the taxonomy of the Meretrix genus. The DNA molecular information is useful and can easily identify them accurately and quickly, especially the sequence of mitochondrial DNA. In this study, a PCR method to analyze the mitochondrial cytochrome c oxidase II (COII) gene was developed to rapidly identify of M. lusoria, M. lamarckii, M. lyrata and M. petechialis. Four different species …

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Bearing Capacity Factor Characteristics Of Footings On Double-Layered Cohesive Soils, Chao-Ming Chi, Zheng-Shan Lin, Yu-Shu Kuo Jan 2023

Bearing Capacity Factor Characteristics Of Footings On Double-Layered Cohesive Soils, Chao-Ming Chi, Zheng-Shan Lin, Yu-Shu Kuo

Journal of Marine Science and Technology–Taiwan

In this study, the bearing capacity of a surface foundation resting on a double-layered cohesive soil profile was investigated by applying a rotational mechanism and finite-difference numerical simulations. The bearing capacity factor behaviors of a surface footing on double-layered cohesive soils can be classified and illustrated using a characteristic chart. Depending on the soil strata strength ratio and normalized layer thickness, the soil-foundation system can be in the squeezing, factor-increasing, factor-decreasing, or constant factor zones. The results indicated that the trend of the curves in the characteristic chart computed from the asymmetric failure mechanism was in accordance with that of …

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Research On Ice Resistance Of Ships Sailing In Floating Ice Floe, Zhixin Xiong, Xinyuan Wu, Yang Li Jan 2023

Research On Ice Resistance Of Ships Sailing In Floating Ice Floe, Zhixin Xiong, Xinyuan Wu, Yang Li

Journal of Marine Science and Technology–Taiwan

To study the ice resistance of ships in areas with floating ice, the Xuelong 2 icebreaker was simulated. A floating-ice model was established using the discrete-element method, and an ice particle array was generated using MATLAB. The effects of ice coverage and speed on ice drag were studied From the numerical simulation results, it can be seen that there is a certain trend in ice resistance under different ice coverage ranges, which changes with the change of speed.By comparing with the empirical formula and the numerical value of the ship model test, this numerical simulation results are relatively accurate.It also …

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The Pre-Processing Of Wt Blade Images By Ss And Bilateral Filter With Machine Learning Frameworks, Joy Iong-Zong Chen, Chien-Yeh Lee, Wien-Chieh Lo Jan 2023

The Pre-Processing Of Wt Blade Images By Ss And Bilateral Filter With Machine Learning Frameworks, Joy Iong-Zong Chen, Chien-Yeh Lee, Wien-Chieh Lo

Journal of Marine Science and Technology–Taiwan

This paper discusses the motivation behind turbine migration and addresses the challenges of using NN (neural network) computing systems. Moreover, it focuses on high-dimensional data from WT (wind turbine) blades. The three key aspects addressed in this study are turbine migration, overfitting, and strict feature selection. To evaluate the performance of the machine learning system, the study considers the characteristics of WT blades, specifically the similarity in blade color and the differences in shape. The authors apply pre-processing techniques, in particular a bilateral filter, in conjunction with the SS (selective synthesizer) of blade fouling patterns. The SS method adopts the …

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Generation Of Chimeric Rhinoviruses Presenting Sars-Cov-2 Broadly Neutralizing Epitopes And Their Antigenicity Characterization, Danish Ansari Jan 2023

Generation Of Chimeric Rhinoviruses Presenting Sars-Cov-2 Broadly Neutralizing Epitopes And Their Antigenicity Characterization, Danish Ansari

Biotechnology Theses

The global COVID pandemic is not yet fully under control as there were over 21 million new cases of SARS-CoV-2 infections and over 50,000 deaths globally as of January of 2022. A heavily mutated variant of concern, Omicron is responsible for most of these cases which demands an urgency for a new vaccine. NIH reports over 180 vaccine candidates that use various strategies currently in development. However, a recurring concern with these vaccines is that the continuous viral mutations decrease the efficacy of vaccines. Therefore, we proposed to construct a human rhinovirus (HRV) based chimeric virus containing highly conserved, broadly …

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A Review Of Alternative Proteins For Vegan Diets: Sources, Physico-Chemical Properties, Nutritional Equivalency, And Consumer Acceptance, Rutwick Surya Ulhas, Rajeev Ravindran, Alok Malviya, Anushree Priyadarshini, Brijesh K. Tiwari, Gaurav Rajauria Jan 2023

A Review Of Alternative Proteins For Vegan Diets: Sources, Physico-Chemical Properties, Nutritional Equivalency, And Consumer Acceptance, Rutwick Surya Ulhas, Rajeev Ravindran, Alok Malviya, Anushree Priyadarshini, Brijesh K. Tiwari, Gaurav Rajauria

Articles

Alternate proteins are gaining popularity as a more sustainable and environmentally friendly alternative to animal-based proteins. These proteins are often considered healthier and are suitable for people following a vegetarian or vegan diet. Alternative proteins can be recovered from natural sources like legumes, grains, nuts, and seeds, while single cell proteins (mycoproteins), and algal proteins are being developed using cutting-edge technology to grow fungus, yeast and algal cells in a controlled environment, creating a more sustainable source of protein. Although, the demand for alternative protein products is increasing, there still happens to be a large gap in use among the …

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Evaluation Of Feed Additives And Delivery Method For Receiving And Finishing Cattle, Thiago Lauro Maia Ribeiro Jan 2023

Evaluation Of Feed Additives And Delivery Method For Receiving And Finishing Cattle, Thiago Lauro Maia Ribeiro

Electronic Theses and Dissertations

Trace minerals (TM) and vitamins are essential to improve production output and efficiency in beef cattle. The first experiment was conducted to investigate if the delivery method of TM and Saccharomyces cerevisiae yeast culture influence growth performance and hepatic TM content of receiving steers. The second experiment evaluated the effect of supplemental protected B - vitamins to finishing steers. Experiment 1 used Charolais x Angus steers calves (n = 192; 256 ± 14 kg) in a 49-d receiving experiment. Within 36h of weaning, steers were weighed, allotted to 24 pens (n = 8 steers/pen; 8 pens/treatment) and randomly assigned to …

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Stem And Pre-Health Students’ Diminishing Online Conversation Volume Regarding Majors And Careers Within The Field: Why Higher Education Should Care, Susan Roh Jan 2023

Stem And Pre-Health Students’ Diminishing Online Conversation Volume Regarding Majors And Careers Within The Field: Why Higher Education Should Care, Susan Roh

Electronic Theses and Dissertations

The purpose of this study was to determine the STEM and pre-health online mention volume change regarding STEM and pre-health majors, careers, and universities, with the data collection period encompassing August of 2018 through June of 2021. We evaluated if the mention sentiment shifted between academic year periods. The data gathered for this study was procured in collaboration with Campus Sonar and the social-listening tool of Brandwatch, which allowed for specifications of the data collected. Kruskal-Wallis tests were used to determine the means of the majors, careers, and universities mentions and mean sentiment volumes. Changes in not only online conversation …

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Development Of Novel Cellular Assay Model And Therapeutic Deep Eutectic Solvents To Optimize The Activity Of Anticancer Agents, Nizam Uddin Jan 2023

Development Of Novel Cellular Assay Model And Therapeutic Deep Eutectic Solvents To Optimize The Activity Of Anticancer Agents, Nizam Uddin

Electronic Theses and Dissertations

Multidrug resistance (MDR) is the major burden behind chemotherapeutic treatment failure. It is the principal mechanism by which cancer cells evade chemotherapeutic treatment. As a result, aggressive cancer cells survive and continue uncontrolled cell division. Multidrug resistance affects survival rate of almost all types of cancer patients and death toll rises at an alarming rate. There are seven different mechanisms for evolving MDR. The most common mechanism in efflux activity of overexpressed ABC transporters. MRP1 is a prominent ABC transporter that pumps out a wide variety of anticancer drugs from the cells and thereby reduces intracellular drug concentrations and develops …

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Physically Adjusted Neutral Detergent Fiber System: Effects Of Dextrose And Non-Forage Fiber On Performance, Feeding Behavior, Digestibility, Rumen Fermentation And Rumen Bacterial Abundance In Dairy Cattle, Jorge Luis Bonilla Urbina Jan 2023

Physically Adjusted Neutral Detergent Fiber System: Effects Of Dextrose And Non-Forage Fiber On Performance, Feeding Behavior, Digestibility, Rumen Fermentation And Rumen Bacterial Abundance In Dairy Cattle, Jorge Luis Bonilla Urbina

Electronic Theses and Dissertations

The newly proposed physically adjusted NDF system (paNDF) system aims to maintain a favorable rumen environment (e.g., pH) by taking into account both the physical and chemical composition of diet. Thus, the objective of this study was to determine the effects of water-soluble carbohydrates (WSC) and non-forage NDF inclusion in a paNDF system on production performance, rumen pH and fermentation profile, rumen bacterial abundance, feeding behavior and nutrient digestibility in late-lactating Holstein cows. Nine fistulated multiparous Holstein cows (2nd and 3rd parity) were used in a triplicated 3×3 Latin Square experiment. Each period lasted for 21 d with 14 d …

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Evaluation Of Yeast Postbiotic In Sow Diets On Sow And Offspring Performance And Microbial Succession, Joel Kieser Jan 2023

Evaluation Of Yeast Postbiotic In Sow Diets On Sow And Offspring Performance And Microbial Succession, Joel Kieser

Electronic Theses and Dissertations

Litter size and the resulting nutritional demand on the sow continue to increase while sow mortality and culling rate are also increasing. Non-nutritive feed additives may enhance sow health and thereby improve offspring growth and productivity after weaning. Development of the gut microbiome in piglets via microbial succession is critical for maximizing their productivity and providing stability for overcoming weaning stress. The objective of this study was to evaluate the impact of yeast-based postbiotic supplementation in gestation and lactation diets on offspring performance through the nursery period and on whether a yeast postbiotic could impact the sow fecal microbiome as …

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Effect Of Genotypes On Rancidity Development During Storage Of Naked Oats, Aastha Gautam Jan 2023

Effect Of Genotypes On Rancidity Development During Storage Of Naked Oats, Aastha Gautam

Electronic Theses and Dissertations

Oats, rich in lipids, lipase, and unsaturated fatty acids, can develop bitterness from triglyceride hydrolysis and unpleasant aromas through unsaturated fatty acid oxidation. To counteract these effects, the processing of hulled oats includes kilning, a step aimed at inactivating the enzymes responsible for lipid degradation. Kilning plays a crucial role in preserving the quality of oats by preventing undesirable flavors development linked to lipid breakdown. Despite the benefits of free threshing and absence of a dehulling requirement in naked oats, assessing lack of enzyme inactivation during processing is crucial for potential storage rancidity issues. Our aim was to determine the …

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