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Full-Text Articles in Life Sciences

Measuring The Production Of Migratory Westslope Cutthroat Trout In Tributaries To Priest River, Idaho, Collin J. Hendricks Jan 2023

Measuring The Production Of Migratory Westslope Cutthroat Trout In Tributaries To Priest River, Idaho, Collin J. Hendricks

EWU Masters Thesis Collection

Iteroparous salmonids that exhibit a migratory life history are essential to functioning metapopulations. They are demographically important as migratory females produce more eggs than non-migratory individuals. Additionally, they provide genetic support through gene flow, resulting in more robust, genetically diverse populations. The lower Priest River flows into the Pend Oreille River in the panhandle of northern Idaho and is a system susceptible to degrading conditions due to increasing water temperature. It is also, a significant contributor of migratory Westslope Cutthroat Trout Oncorhynchus clarkii lewisi (WCT) in the Clark- Fork Pend Oreille Basin (CFPOR). The goal of our study was to …

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Crisis Communication And Public Relations: How Fairs Communicated Cancellations During The Covid-19 Pandemic, Olivia Mckenna Robinson Jan 2023

Crisis Communication And Public Relations: How Fairs Communicated Cancellations During The Covid-19 Pandemic, Olivia Mckenna Robinson

Graduate Theses/Dissertations

The COVID-19 pandemic halted aspects of a traditional fair including the agriculture, home economics, entertainment, and carnival exhibits that were missed by the diverse stakeholders who enjoy the traditions of this industry. This study examined how fairgoers reacted to the news of cancellation and investigated fair managers’ communication decisions. An explanatory sequential (QUANT → QUAL) mixed methods design was used. A survey was conducted asking fairgoers to recall communication strategies and feelings after the communication. A more in-depth focus group with fair managers was hosted to understand how crisis communication was utilized, and if active information seekers versus passive information …

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Impact Of Sample Conditions On Dna Phosphodiester Backbone Bi/Bii Conformational Equilibrium Dynamics, Autumn C. Pilarski Jan 2023

Impact Of Sample Conditions On Dna Phosphodiester Backbone Bi/Bii Conformational Equilibrium Dynamics, Autumn C. Pilarski

Graduate Theses/Dissertations

DNA damage, such as single base lesions and mismatches, is highly prevalent within cells. If these DNA damage events are not repaired, they could lead to mutations and thus disease and cancer. Intricate repair mechanisms are in place to fix these damage events, one such being Base Excision Repair (BER) and associated enzyme: Thymine DNA Glycosylase (TDG). The first step of this repair process, recognition of the lesion by TDG, is not well understood. The following thesis presents results to better understand the fundamental biophysical question of how a DNA lesion within a mismatch context is recognized in a million …

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Investigating The Role Of Lim Kinase In Embryonic Development, Nehul Dharmesh Tanna Jan 2023

Investigating The Role Of Lim Kinase In Embryonic Development, Nehul Dharmesh Tanna

Senior Honors Theses and Projects

Cellular communication is important in embryonic development. It facilitates timely migration and maturation of cells to produce a fully functional organism using cell signaling pathways. These pathways involve receptors, ligands, and intracellular enzymes to produce different effects in the cell. One such pathway, the EphA4 signaling pathway, is involved in altering the cytoskeleton of eukaryotic cells. LIM kinases (LIMKs) are enzymes that regulate important components of the cytoskeleton. We hypothesized involvement of LIMKs in the EphA4 pathway and investigated their involvement in X. laevis embryonic development as a first step toward evaluating this hypothesis. We mutated LIMK genes in frog …

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Cul3 Negatively Regulates Nlrp12-Mediated Inhibition Of The Canonical Nf-Κb Signaling Pathway, Inyeong Lee Jan 2023

Cul3 Negatively Regulates Nlrp12-Mediated Inhibition Of The Canonical Nf-Κb Signaling Pathway, Inyeong Lee

Graduate Theses/Dissertations

Nod-like receptor family pyrin domain-containing protein 12 (NLRP12) is mainly known for its inhibitory function on NF-κB signaling in innate immune cells, and more recently, for its ability to regulate chemokine signaling and ubiquitination of the immune receptor RIG-I. Through a yeast 2-hybrid screen, the Lupfer lab previously discovered that NLRP12 interacts with other ubiquitin-associated proteins including Cullin 3 (CUL3) and RING finger protein 2 (RNF2). This research was conducted to mainly investigate the interaction between NLRP12 and CUL3 in human cells and examine the role in regulating NF-κB signaling. Previously, co-immunoprecipitation, followed by western blot analysis, and confocal microscopy …

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Sex-Dependent Effects Of Induced Acute Inflammation On Glucose Homeostasis And Rna Editing Enzymes, Christian A. Rivas Jan 2023

Sex-Dependent Effects Of Induced Acute Inflammation On Glucose Homeostasis And Rna Editing Enzymes, Christian A. Rivas

Graduate Theses/Dissertations

The first line of defense against bodily insults, like pathogen invasion, is the innate immune system. Innate immunity sets in motion countless cascades that result in inflammation. Inflammation simultaneously affects multiple biological processes like metabolism and gene expression. Males and females react differently to inflammation. To understand both molecular and physiological sex differences in inflammation, we examined how inflammation affects gene expression and glucose metabolism. Adenosine deaminase acting on RNA (ADAR1) is upregulated by inflammation and catalyzes RNA editing, a process where nucleotides encoded by the genome are modified. ADAR1 also controls the innate immune reaction by decreasing activity of …

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Sexism And Racism In Stem: A Bleak History And A Bright Future, Abigail Hoskins Jan 2023

Sexism And Racism In Stem: A Bleak History And A Bright Future, Abigail Hoskins

Senior Honors Theses and Projects

Women and people of color have faced discrimination throughout history, and this inequity persists today. This results in low numbers of women and people of color in STEM and leads to stereotypes and bias as well as harassment, financial disparities, and erasure of their contributions. Current initiatives promote equality and equity in STEM, such as protests against discriminatory practices and after-school programs encouraging youth from marginalized groups to participate in STEM, but these are not enough. Institutional and structural changes and solutions that address the intersectional needs of women and people of color are necessary to ensure equity and equality …

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Microbial Communities Improve Growth Of Slow-Growing, Uncommon Legumes In A Restored Prairie, Alex Chumney Jan 2023

Microbial Communities Improve Growth Of Slow-Growing, Uncommon Legumes In A Restored Prairie, Alex Chumney

Senior Honors Theses and Projects

Restored prairies are attempts at restoring native prairies, most of which have been lost. However, restoration is often challenging because native prairie plants, such as native prairie legumes, often fail to establish in restored prairies. We hypothesized legume’s failure to establish in restored prairies is due to changes in the microbial communities with which legumes have multi-mutualistic relationships: rhizobia and arbuscular mycorrhizal fungi (AMF). Additionally, we hypothesized that late successional legumes rely on multi-mutualistic relationships for establishment and growth more than early successional legumes, and would respond synergistically to rhizobia and AMF treatments. To test this, we inoculated eight native …

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Impacts Of Viral Infection By Ma-Lmm01 On Microcystin Production By Microcystis Aeruginosa, Amber Elizabeth Haley Jan 2023

Impacts Of Viral Infection By Ma-Lmm01 On Microcystin Production By Microcystis Aeruginosa, Amber Elizabeth Haley

Senior Honors Theses and Projects

Increasing global temperatures and nutrient availability from anthropogenic sources have contributed to climate change and pollution in waterways. Environmental changes have promoted annual harmful algal blooms (HABs), which have the potential to lead to conditions that negatively affect aquatic ecosystems and organisms that depend on them. HABs can impact water quality through the release of soluble toxins (e.g., microcystin), produced by cyanobacteria that can bypass standard drinking water processing protocols. It has been suggested that viral infections of cyanobacteria may contribute to increased production and release of microcystins. In this project, two hypotheses were assessed: 1) virus-mediated lysis releases toxins …

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Tagging Atg5 With An Epitope Tag To Measure The Amount Of Atg12-5 Conjugation In Atg10 Mutants, Sophie Campbell Jan 2023

Tagging Atg5 With An Epitope Tag To Measure The Amount Of Atg12-5 Conjugation In Atg10 Mutants, Sophie Campbell

Senior Honors Theses and Projects

Autophagy is a necessary recycling process that occurs in cells, but the functions of the proteins that carry this out are not completely understood. The protein ATG10 has a distinct role in forming autophagosomes, large double membrane vesicles necessary for this process. ATG10 forms a covalent bond between the proteins ATG12 and ATG5 but its final effect on autophagosome formation is still unclear. We are using DNA manipulation techniques to add a myc epitope tag to yeast ATG5 which will allow us to measure the effect of atg10 mutants on ATG12-5 conjugation via Western Blot. These results will help us …

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Application Of Nitrate To An Anaerobic Subsurface Bioremediation, Cassie Marie Roberts Jan 2023

Application Of Nitrate To An Anaerobic Subsurface Bioremediation, Cassie Marie Roberts

Masters Theses

"The highly contaminated subsurface matrix of the Baird and McGuire Superfund site is currently threatening the health and safety of the surrounding environment of Holbrook, MA. Contaminants of significant concern due to high concentration are inorganic arsenite and petroleum hydrocarbons, such as naphthalene. Parsons Corporation and the Massachusetts Department of Environmental Protection have implemented a bioremediation pilot to attempt to degrade the hydrocarbons and arsenic with the application of nitrate. The nitrate would act as an electron acceptor for biodegradation of the hydrocarbon contaminants, produce nitrite that would oxidize reduced iron, and iron oxides would sequester arsenic. Preliminary data showed …

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Environmental Dna Metabarcoding As A Tool For Fish Community Assessment In Wetlands, Eric Ludwig Jan 2023

Environmental Dna Metabarcoding As A Tool For Fish Community Assessment In Wetlands, Eric Ludwig

Masters Theses

"Environmental DNA (eDNA) metabarcoding is a genetically based method of assessing biodiversity in aquatic environments. While the efficacy of eDNA surveys has been well documented in riverine and marine systems, it has been relatively underemployed in freshwater wetland environments. In this study, we conducted an eDNA metabarcoding survey of fish diversity and its seasonal variation in a wetland along the Mississippi River in the Missouri Bootheel. Samples were collected from both permanent and seasonal water bodies including oxbow lakes, a shallow, man-made lake, a ditch, and a slough. For each of the 28 sites in this study, three water samples …

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Evaluation Of Mesenchymal Stem Cells In Autoimmune Disease: A Systematic Review And Meta-Analysis, Hailey Nicole Swain Jan 2023

Evaluation Of Mesenchymal Stem Cells In Autoimmune Disease: A Systematic Review And Meta-Analysis, Hailey Nicole Swain

Masters Theses

"Mesenchymal stem cells, also known as multipotential stem/progenitor cells and mesenchymal stem/progenitor cells, are denoted by the acronym MSCs. MSCs can differentiate into multiple lineages from different germ layers in vitro, and in limited situations, in vivo. MSCs have broad anti-inflammatory and immune-modulatory properties, which is the greatest focus of MSCs in clinical testing. Despite their promise and use in over 950 clinical trials, pivotal questions remain unanswered. Recent clinical trials have demonstrated that when MSCs are harvested from autoimmune patients, they show a reduction in their therapeutic efficacy in comparison to MSCs from a healthy person. Identifying quality MSCs …

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Peripheral Clock Disruption And Metabolic Disease: Moving Beyond The Anatomy To A Functional Approach, Gabriella M. Marino, Deanna M. Arble Jan 2023

Peripheral Clock Disruption And Metabolic Disease: Moving Beyond The Anatomy To A Functional Approach, Gabriella M. Marino, Deanna M. Arble

Biological Sciences Faculty Research and Publications

Sleep and circadian disruption are associated with an increased risk of metabolic disease, including obesity and diabetes. Mounting evidence indicates that misaligned and/or non-functional clock proteins in peripheral tissues critically contribute to the presentation of metabolic disease. Many of the foundational studies which led to this conclusion have focused on specific tissues such as the adipose, pancreas, muscle, and liver. While these studies have greatly advanced the field, the use of anatomical markers to manipulate tissue-specific molecular clocks may not be representative of the circadian disruption that occurs within the clinical population. In this manuscript, we argue that investigators can …

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Navigating Rice Seedling Cold Resilience: Qtl Mapping In Two Inbred Line Populations And The Search For Genes, Michael Schläppi, Avery R. Jessel, Aaron K. Jackson, Huy Phan, Melissa H. Jia, Jeremy D. Edwards, Georgia C. Eizenga Jan 2023

Navigating Rice Seedling Cold Resilience: Qtl Mapping In Two Inbred Line Populations And The Search For Genes, Michael Schläppi, Avery R. Jessel, Aaron K. Jackson, Huy Phan, Melissa H. Jia, Jeremy D. Edwards, Georgia C. Eizenga

Biological Sciences Faculty Research and Publications

Due to global climate change resulting in extreme temperature fluctuations, it becomes increasingly necessary to explore the natural genetic variation in model crops such as rice to facilitate the breeding of climate-resilient cultivars. To uncover genomic regions in rice involved in managing cold stress tolerance responses and to identify associated cold tolerance genes, two inbred line populations developed from crosses between cold-tolerant and cold-sensitive parents were used for quantitative trait locus (QTL) mapping of two traits: degree of membrane damage after 1 week of cold exposure quantified as percent electrolyte leakage (EL) and percent low-temperature seedling survivability (LTSS) after 1 …

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Temperature Regulation Of Pipecolic Acid-Mediated Plant Systemic Immunity In Arabidopsis Thaliana, Alyssa Shields Jan 2023

Temperature Regulation Of Pipecolic Acid-Mediated Plant Systemic Immunity In Arabidopsis Thaliana, Alyssa Shields

Theses and Dissertations (Comprehensive)

Significant crop losses are caused by pathogenic infections annually, which are exacerbated by increasing global temperatures due to climate change. One way by which plants respond to pathogenic attacks is through the activation of pattern-triggered immunity (PTI), effector-triggered immunity (ETI), and systemic acquired resistance (SAR), which lead to production of the central defence phytohormone salicylic acid (SA). Accompanying SA release is the putative mobilization of pipecolic acid (Pip), which acts as an immune regulatory plant metabolite that works with and independently from SA. As demonstrated in the model plant Arabidopsis thaliana following infection with the model bacterial pathogen Pseudomonas syringae …

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Apobec3 Regulation By Thyroid Hormone, Michelle Santiago Jan 2023

Apobec3 Regulation By Thyroid Hormone, Michelle Santiago

All Graduate Theses, Dissertations, and Other Capstone Projects

Thyroid hormone (TH) is crucial for many biological processes, including the development of the auditory system. Appropriate thyroid hormone signaling is important for the development of the cochlea, leading to the successful onset of hearing. More specifically, TH influences the timing of remodeling of the greater epithelial ridge (GER), a transient cochlear structure that secretes proteins that contribute to the formation of the tectorial membrane. Developmental hypothyroidism results in delayed GER regression, whereas excess TH results in premature remodeling. Both conditions result in deafness. However, it is unknown how TH mediates GER remodeling. Expression profiling identified APOBEC3 (A3) as a …

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American Sign Language (Asl): Linguistically And Cognitively - Why Deaf People Should Learn Asl & Learn It Early, Helena Isabel Berczes Jan 2023

American Sign Language (Asl): Linguistically And Cognitively - Why Deaf People Should Learn Asl & Learn It Early, Helena Isabel Berczes

Undergraduate Honors Theses

This thesis presents data supporting the value of including American Sign Language (ASL) in the education of Deaf people. Historically, Deaf education has not fully included or has excluded ASL in an effort to focus on English due to a belief that ASL hinders learning English. ASL must fit within the definition of language with unique linguistic features for its inclusion in language education. Plasticity of the brain lends itself to the ability for language processing networks to form based on language experience. Deaf people can fully access visual language versus auditory language. Therefore, acquiring ASL early in life, during …

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The Covid-19 Pandemic And Its Influence On The Human Immune System, Nicole L. Riha Jan 2023

The Covid-19 Pandemic And Its Influence On The Human Immune System, Nicole L. Riha

Undergraduate Honors Theses

COVID-19 rapidly infected the world, and scientists continue to research how the disease spread and killed as many as it did by analyzing how it affects the human immune system and referring to past pandemics. Since the pandemic is ongoing, scientists do not fully understand how the virus works and if lockdowns were effective. Nevertheless, a discussion on what is known about COVID-19's influence on the human immune system is needed. With an understanding of the COVID-19 pandemic, scientists can make more effective treatments for COVID-19 and learn how to manage future pandemics.

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Nsaids And Oral Drug Absorption: Ibuprofen Through A Pharmacokinetic Lens, Courtney Gant Jan 2023

Nsaids And Oral Drug Absorption: Ibuprofen Through A Pharmacokinetic Lens, Courtney Gant

Undergraduate Honors Theses

Human pharmacokinetics is the study of how administered medications move throughout and behave within the body. Absorption, distribution, metabolism, and excretion are four integral parts of this field of study and are commonly known as the ADME principles of pharmacokinetics, but other processes are studied within the field. For orally administered drugs, the absorption process lies within the small intestine and colon, two components of the gastrointestinal (GI) tract; this bodily system is associated with many variables––many of which must be considered in the study of oral drug absorption. Often administered orally, non-steroidal anti-inflammatory drugs (NSAIDs) make up a group …

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Porifera: Biology And Medicinal Properties, Emma L. Rayfield Jan 2023

Porifera: Biology And Medicinal Properties, Emma L. Rayfield

Undergraduate Honors Theses

The focus of this thesis is the possibility of oceanic medicine through understanding the general biology of poriferans, their symbionts, medicinal properties, and how we could harvest sponges conservatively. It was necessary to understand the basic biology of poriferans regarding their structures, differences in their classes, and how they obtain nutrition, develop, and reproduce. The ecology of the poriferans was also researched including their larval and sessile stages and how their environment determines where they settle. Additionally, ecology was examined including how poriferans interact with symbionts and other organisms. This then was utilized to seek whether poriferans had useful medical …

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Genome Sequence Of Subcluster L3 Mycobacterium Smegmatis Mc2155 Phage Duncansleg, Megan Cevasco, Kaitlynn Burbage, Connor Hadwin, Edenborough Hibionada, Kirsten Presnell, Daniel Williams Jan 2023

Genome Sequence Of Subcluster L3 Mycobacterium Smegmatis Mc2155 Phage Duncansleg, Megan Cevasco, Kaitlynn Burbage, Connor Hadwin, Edenborough Hibionada, Kirsten Presnell, Daniel Williams

Biology

Bacteriophage DuncansLeg is a siphovirius isolated in 2021 from soil on the Coastal Carolina University campus in Conway, South Carolina, using the host Mycobacterium smegmatis mc2155. DuncansLeg has a 75,593-bp circular genome that contains 126 predicted protein-coding genes and 10 tRNA genes. DuncansLeg is assigned to actinobacteriophage cluster L3.

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Genome Sequences Of Six Cluster Ct And Two Cluster Dj Bacteriophages That Infect Gordonia Rubripertincta, Xavier F. Rodriguez, Daniel C. Williams, Catherine P. Chia Jan 2023

Genome Sequences Of Six Cluster Ct And Two Cluster Dj Bacteriophages That Infect Gordonia Rubripertincta, Xavier F. Rodriguez, Daniel C. Williams, Catherine P. Chia

Biology

We report the genome sequences of eight bacteriophages isolated using Gordonia rubripertincta NRRL B-16540-SEA. Based on gene content similarity to phages in the Actinobacteriophage database, six of the phages are assigned to phage cluster CT while two are assigned to cluster DJ.

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Cisplatin - Loaded Calcium Citrate Nanoparticlesfor Inhibition Of Lung Cancer Cell Growthand Quantum Mechanical Study Of Cisplatin And Citrate, Lipika Oopkaew Jan 2023

Cisplatin - Loaded Calcium Citrate Nanoparticlesfor Inhibition Of Lung Cancer Cell Growthand Quantum Mechanical Study Of Cisplatin And Citrate, Lipika Oopkaew

Chulalongkorn University Theses and Dissertations (Chula ETD)

The International Organization for Research on Cancer (International Agency for Research on Cancer (IARC) issued a statement saying lung cancer is a cancer with high incidence rates of new cases and deaths. Although there are current therapeutic approaches such as surgery, radiation therapy, and chemotherapy. However, these treatments exhibit ineffectiveness; the main limitation is severe side effects to normal cells or non-target organs. To address this challenge, the development of targeted therapy by nanoparticle-based drug delivery system is applied to increase drug stability and control the specificity to cancer cells with target-specific proteins that play an important role in intracellular …

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Characterization Of Animal And Plant Proteins Glycated With Konjac Glucomannan Hydrolysate, Pachara Pomsang Jan 2023

Characterization Of Animal And Plant Proteins Glycated With Konjac Glucomannan Hydrolysate, Pachara Pomsang

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to prepare Konjac glucomannan hydrolysate (KGMH) and investigate its glycation with animal and plant proteins through the Maillard reaction, focusing on varying degrees of polymerization (DPs). Initially, KGMH was produced from high-content Konjac glucomannan (KGM) using beta-mannanase (200 to 300 U/g) within 60 minutes, resulting in KGMH with DPs ranging from 2 to 9 and reduced viscosity. Under optimized conditions (40% KGM and 250 U/g enzyme), KGMH samples with the widest DP range (4.20 to 6.11) were used to assess antioxidant and antiglycation activities. Lower DPs of KGMH showed superior antioxidant activities in DPPH and ABTS assays …

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Development Of Novel Detection Methods For Food Safety Using State-Of-The-Art Technology Platforms, Prae Noppakuadrittidej Jan 2023

Development Of Novel Detection Methods For Food Safety Using State-Of-The-Art Technology Platforms, Prae Noppakuadrittidej

Chulalongkorn University Theses and Dissertations (Chula ETD)

Foodborne illness is a significant global public health concern, impacting both the economy and human health. These illnesses are caused by bacteria, viruses, parasites, toxins, and chemicals. This research developed two technology platforms for Bacillus cereus and tropane alkaloid compounds detections. First, traditional detection methods for B. cereus have limitations in long analysis time, and dependence on analysis and interpretation by skilled personnel. Therefore, this study introduces a robust detection method using peptide nucleic acids (PNAs) bearing with a prolyl-2-aminocyclopentanecarboxylic acid (ACPC) backbone as probes in a bead array method. PNAs with groEL, motB, and 16S rRNA sequences were covalently …

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Characterizing The Dynamic Localization Of Cmi In Early Drosophila Development, Asra Habibullah Jan 2023

Characterizing The Dynamic Localization Of Cmi In Early Drosophila Development, Asra Habibullah

Master's Theses

The COMPASS-like family of lysine methyltransferases, MLR/MLX complexes, are epigenetic regulators that are essential for normal development through the methylation of the fourth lysine residue on histone 3 (H3K4), a universal epigenetic mark associated with active transcription. This family of complexes is highly conserved from yeast to mammals and the genes encoding the human MLR complexes have been associated with various developmental diseases and cancers (Dingwall and Fagan, 2019). In D. melanogaster, the enzymatic methyltransferase core of this complex is composed of two proteins: Cara Mitad (Cmi, also known as Lpt) and Trithorax-related (Trr). Although these proteins have been shown …

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Dynamic Control Of The Cardiac Calcium Pump, Sean Robert Cleary Jan 2023

Dynamic Control Of The Cardiac Calcium Pump, Sean Robert Cleary

Dissertations

The sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) sequesters Ca2+ into the endoplasmic reticulum of cells to establish a reservoir for Ca2+ signaling. In the heart, the activity of this transporter is tightly controlled via direct interactions with two competing regulatory micropeptides: phospholamban (PLB) and dwarf open reading frame (DWORF). PLB inhibits SERCA, while DWORF activates SERCA. These competing interactions determine cardiac performance by modulating the Ca2+ signals that drive the contraction/relaxation cycle. Previous studies indicated these SERCA-micropeptide interactions are Ca2+-sensitive; SERCA binds PLB more avidly at low cytoplasmic [Ca2+] but binds DWORF better when [Ca2+] is high. Here, FRET-microscopy demonstrated that this …

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Targeting The Subacute Progression Of Hippocampal Cellular Senescence Following Repetitive Mild Traumatic Brain Injury, Jacob Edward Exline Jan 2023

Targeting The Subacute Progression Of Hippocampal Cellular Senescence Following Repetitive Mild Traumatic Brain Injury, Jacob Edward Exline

Master's Theses

Repetitive mild traumatic brain injury (rmTBI) increases an individual’s risk for developing persistent deficits in recognition memory with symptoms experienced by up to 30% of rmTBI patients. Cellular senescence has been suggested as an underlying mechanism of persistent rmTBI symptoms; however, the subacute progression of cellular senescence following rmTBI has not been evaluated. Furthermore, the use of subacute testosterone administration to treat persistent recognition memory deficits and the cellular and molecular underpinnings has yet to be well characterized. Our lab utilizes a 5-hit closed-head rmTBI rat model to induce deficits in recognition memory and determine the effects of subacute testosterone …

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Identification Of New Substrates From Pseudomonas Aeruginosa Exos, Adam V. Thota Jan 2023

Identification Of New Substrates From Pseudomonas Aeruginosa Exos, Adam V. Thota

Master's Theses

Pseudomonas aeruginosa is a gram-negative environmental bacterium that uses its intrinsic and acquired antibiotic resistance to infect patients with compromised epithelium, such as cystic fibrosis and burn wounds, and corneal keratitis. In order to cause disease, most strains of P. aeruginosa use the type three secretion system (T3SS) to disrupt cellular signaling and integrity. However, P. aeruginosa may also secrete exotoxins after invading host cells, which prolongs host cell death and maintains an intracellular niche. Of the T3 secreted effector toxins, ExoS, specifically the ADP-ribosyltransferase activity of ExoS, was shown to delay the death of invaded corneal cells, but it …

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