Life Sciences Commons^™

Linking Soil Properties To Originally Wooded And Afforested Areas, Ashton A. Crowe, Matthew Laun

Posters-at-the-Capitol

Linking Soil Properties to Originally Wooded and Afforested Areas

Matthew Laun, Ashton Crowe

Mentor: I. P. Handayani

Hutson School of Agriculture Murray State University, KY, USA

Abstract

Afforestation, adding an artificial forest to a piece of land that has been barren of trees for a significant amount of time, has some seriously huge impacts on the environment. These effects can be seen as an increase in the soil organic matter, a decrease in compaction, and enhancement of porosity. Therefore, the soil can support more diverse microbes and fungal communities leading to better micro and macro nutrient transfers between plants. This …

Foliar Application Of Acetic Acid And Effectiveness Against Drought At Different Time Points In Soybean (Glycine Max) Development, Miranda Rudolph, Megan Taylor Phd.

Posters-at-the-Capitol

Drought is arguably the most serious environmental factor affecting crop production today. A plant's response to drought stress is extremely complex, affecting numerous metabolic pathways that are all interconnected in their responses. Due to this complex nature, scientists do not fully understand the implications of different treatments and how they affect these processes. Acetic acid has been shown to improve plant growth and resistance to drought stress, but exactly how it accomplishes this is also unknown. Soybeans (Glycine max) are one of the most important crops worldwide and can suffer significant yield loss due to drought stress. As climate change …

Economic Feasibility And Consumer Acceptance Of Strawberry Plants As An Additional Offering In Fall Mum Sales, Alyx Shultz, Eva Bogue, Anna Griggs, Allison Croslin

Posters-at-the-Capitol

As consumers become more health conscious and concerned with food production practices, increased market demand had developed for edible plants with ornamental properties. This action research examined the economic feasibility, production realities, and consumer acceptance of offering garden and alpine strawberries at fall mum sales. Each year $173 million in mums are sold in the United States. By offering potted strawberries for sale alongside mums, Kentucky producers may be able to mitigate their risk as well as generate additional on-farm revenue from a proven consumer base and market. Researchers grew 100 garden strawberries and 100 alpine strawberries and offered the …

Dual Ionic Liquid-Functionalized Cellulosic Materials: Thermal, Mechanical And Conductive Properties, Elizabeth Mcgrew, Kevin M. Miller Phd

Posters-at-the-Capitol

Cellulose, an inexpensive and renewable biomacromolecule, represents an intriguing synthetic foundation for new materials with task-specific properties. Here, we wish to report a synthetic route for functionalizing cellulose with a side chain containing two ionic liquid functional groups using azide-alkyne ‘click’ cyclization strategy, followed by quaternization of the two resulting heterocycles (1,2,3-triazole and imidazole). Through this functionalization strategy, the resulting cellulosic materials exhibited significant softening, with several glass transition (T_g) values observed below room temperature, indicating the amorphous nature of the materials, with the T_g dependent on both the length of the side chain and the …

Cellular Zinc Deficiency Impairs Heme Biosynthesis In Developing Erythroid Progenitors, Juyoung Kim, Jaekwon Lee, Moon-Suhn Ryu

Department of Biochemistry: Faculty Publications

Anemia is the most prevalent nutrition-related disorder worldwide. Zinc is an essential trace element for various biological processes in the body, and zinc deficiency has been associated with anemia in humans. However, the molecular mechanisms by which zinc availability alters red blood cell development remain uncertain. The present study identifies the essentiality of zinc during erythroid development, particularly for normal heme biosynthesis. G1E-ER4 mouse cells were used as an in vitro model of terminal erythroid differentiation, which featured elevated cellular zinc content by development. Restriction of zinc import compromised the rate of heme and -globin production and, thus, the hemoglobinization …

A New Species Of Biclonuncaria Razowski And Becker, 1993 (Lepidoptera: Tortricidae: Polyorthini) From Costa Rica, John W. Brown

Insecta Mundi

Biclonuncaria recurvana, new species (Lepidoptera: Tortricidae: Polyorthini), is described and il­lustrated from Area de Conservación Guanacaste in northwestern Costa Rica. It is most similar to B. conica Razowski, 1993, from Mexico, but the two are easily distinguished by features of the male genitalia. Biclo­nuncaria recurvana has been reared (n = 12 specimens) from field-collected larvae feeding on the leaves of Dalbergia glomerata Hemsley (Fabaceae), consistent with the previously reported host plant for B. dalbergiae Razowski and Becker, 1993, which has been reared from Dalbergia in Brazil.

New Species And Taxonomical And Geographical Notes On Cerambycidae And Disteniidae (Coleoptera: Chrysomeloidea), Daniel Heffern, Juan Pablo Botero, Antonio Santos-Silva

Insecta Mundi

Four new species of Coleoptera are described: Pentanodes clavatus new species, from Ecuador; Pentanodes baldwini new species, from Panama (Cerambycidae: Cerambycinae: Tillomorphini); Elytrimita­trix (Grossifemora) dilatata new species, from Mexico (Disteniidae) and Novantinoe falsa new species, from Mexico (Disteniidae). Taxonomical notes on Euderces cribellatus (Bates, 1885) (Tillomorphini) and Oreodera Audinet-Serville, 1835 (Lamiinae: Acrocinini) are provided. Additionally, new records are provided for Oreo­dera noguerai McCarty, 2001 (new state record), Adetus croton Heffern, Santos-Silva and Botero, 2019 (new country record), Icimauna sarauaia Martins and Galileo, 1991 (new country record), and Phoebe mexicana Bates, 1881 (new state record).

Sheep Grazing Trigonella Balansae Had Productivity, Health And Meat Quality Similar To Sheep Grazing Subterranean Clover Or French Serradella, M. G. Wilmot, Hayley C. Norman, Joshua Hendry, Paul Young, Elizabeth Hulm, Andrew Toovey, Jane Speijers, Robert J. Harrison

Animal production and livestock research articles

Context: An accession of the annual legume Trigonella balansae Boiss. & Reuter. has been selected for commercial release in Australia.

Aims: As part of a duty-of-care assessment, we tested the hypothesis that sheep grazing the trigonella accession will have liveweight, condition scores and wool production similar to those of sheep grazing two widely adopted annual legumes, subterranean clover (subclover, Trifolium subterraneum L. cv. Dalkeith) and French serradella (Ornithopus sativus Brot. cv. Erica). We also hypothesised that sheep grazing the three legumes will have similar meat quality and health, as indicated by blood plasma panel analysis.

Methods: Wethers (n …

Assessment Of Carbon Productivity Dynamics In Aspen Stands Under Climate Change Based On Forest Inventories In Central Siberia, Andrey Andreevich Vais, Valentina Valerievna Popova, Alina Andreevna Andronova, Viktor Nikolaevich Nemich, Artem Gennadievich Nepovinnykh, Pavel Vladimirovich Mikhaylov

Aspen Bibliography

The aim of the present research was to study the dynamics of growth and conditions of aspen stands under climate change, according to different periods of forest inventory. The study was conducted in modal aspen forests growing in the subtaiga/forest steppe region of Central Siberia. Aspen forests grow intensively at young age, which allows them to realize maximum carbon sequestration potential. The research was based on forest inventory data from 1972, 1982, 2002, and 2021 (the study was conducted on a limited territory). There was a steady increase in temperatures in the growing season from 1982 to 2002. The amount …

Extracellular Vesicles Of Human Diabetic Retinopathy Retinal Tissue And Urine Of Diabetic Retinopathy Patients Are Enriched For The Junction Plakoglo Bin Protein, Rajendra Gharbaran

Publications and Research

Introduction: Diabetic Retinopathy (DR) is a potentially blinding retinal disorder that develops through the pathogenesis of diabetes. The lack of disease predictors implies a poor prognosis with frequent irreversible retinal damage and vision loss. Extracellular Vesicles (EVs) present a novel opportunity for pre-symptomatic disease diagnosis and prognosis, both severely limited in DR. All biological fluids contain EVs, which are currently being studied as disease biomarkers. EV proteins derived from urine have emerged as potential noninvasive biomarkers.

Methods: In this study, we isolated EVs from DR retinal tissue explants and from DR patients' urine, and characterized the vesicles, finding differences in …

Ecological Complexity And Avoiding Pest Resurgence: Intuitions From Mathematical Ecology, Theresa Ong, John H. Vandermeer

Dartmouth Scholarship

Pest resurgence is defined by a predictable increase in pests following declines resulting from the implementation of pest management practices. This phenomenon is notorious; familiar in biblical references to cyclical plagues of locust and discussions of pesticide treadmills, where pests resurge following the evolution of pesticide resistance. Targeted “silver-bullet” approaches, whether chemical, mechanical, biological, or genetic in nature, apply a reductionist lens toward the removal of a specific target pest, often ignoring ecological context, by application of said silver-bullet. In this review article, we cover how past and recent developments in theoretical ecology and complex systems dynamics provide a general …

Scavenger Receptor B1 Facilitates The Endocytosis Of Escherichia Coli Via Tlr4 Signaling In Mammary Gland Infection, Qamar Taban, Syed Mudasir Ahmad, Peerzada Tajamul Mumtaz, Basharat Bhat, Ehtishamul Haq, Suhail Magray, Sahar Saleem, Nadeem Shabir, Amatul Muhee, Zahid Amin Kashoo, Mahrukh Hameed Zargar6, Abrar A. Malik, Nazir A. Ganai, Riaz A. Shah

Department of Nutrition and Health Sciences: Faculty Publications

SCARB1 belongs to class B of Scavenger receptors (SRs) that are known to be involved in binding and endocytosis of various pathogens. SRs have emerging role in regulating innate immunity and host–pathogen interactions by acting in co-ordination with Toll-like receptors.Query Little is known about the function of SCARB1 in milk-derived mammary epithelial cells (MECs). This study reports the role of SCARB1 in infection and its potential association in TLR4 signaling on bacterial challenge in Goat mammary epithelial cells (GMECs). The novelty in the establishment of MEC culture lies in the method that aims to enhance the viability of the cells …

Chronic Conditions, Late Mortality, And Health Status After Childhood Aml: A Childhood Cancer Survivor Study Report, Lucie M Turcotte, Jillian A Whitton, Wendy M Leisenring, Rebecca M Howell, Joseph P Neglia, Kevin C Oeffinger, William G Woods, E Anders Kolb, Leslie L Robison, Gregory T Armstrong, Eric J Chow

Faculty, Staff and Student Publications

Five-year survival following childhood acute myeloid leukemia (AML) has increased following improvements in treatment and supportive care. Long-term health outcomes are unknown. To address this, cumulative incidence of late mortality and grades 3 to 5 chronic health condition (CHC) were estimated among 5-year AML survivors diagnosed between 1970 and 1999. Survivors were compared by treatment group (hematopoietic cell transplantation [HCT], chemotherapy with cranial radiation [chemo + CRT], chemotherapy only [chemo-only]), and diagnosis decade. Self-reported health status was compared across treatments, diagnosis decade, and with siblings. Among 856 survivors (median diagnosis age, 7.1 years; median age at last follow-up, 29.4 years), …

Fire Impacts And Dynamics Of Seasonally Dry Tropical Forest Of East Java, Indonesia, Sutomo, Eddie J. B. Van Etten

Research outputs 2022 to 2026

Background: Seasonally dry tropical forests (SDTFs) are globally important ecosystems which receive less research attention compared to tropical rainforests but are equally under serious threat. The objectives of this paper are to characterize the vegetation structure, diversity and composition of SDTF of Baluran National Park, East Java, Indonesia, and to assess the impact of burning this SDTF and its post-fire recovery. Methods: In the field, we measured floristic composition and dominance at sites with different fire histories in both SDTF and adjacent savannas of Baluran. Remote sensing image analysis was also employed using the MODIS burn area product and various …

Progress Towards The Total Synthesis Of Frondosin D Lab Report, Admirabilis Kalolella

CISLA Senior Integrative Projects

No abstract provided.

Intro To Primary Sources, Katie Strand, Jen Kirk, Dan Davis, Lara Petersen

All E-Learning Resources

Attention: As of 2026 updated versions of this item will no longer be available on Digital Commons. Please contact [email protected] for more information.

The Identifying Primary Sources tutorial teaches students how they find, evaluate, and use primary sources in their own research. Along the way, they'll learn about some great places to start researching when looking for primary sources.

Degradation Assessment Of Archaeological Oak (Quercus Spp.) Buried Under Oxygen-Limited Condition, Amir Ghavidel, Amin Jorbandian, Miklos Bak, Jana Gelbrich, Jeffrey J. Morrell, Ion Sandu, Reza Hosseinpourpia

Michigan Tech Publications, Part 1

The biological deterioration of archaeological wood under oxygen-limited conditions varies due to the limited activities of microorganisms. It is essential to expand the knowledge of the degradation types and the status of archaeological monuments for selecting the proper consolidates. The physical, chemical, and anatomical properties of approximately 600-650 year old archaeological oak collected from an archaeological site in Iasi-Romania were analysed to assess the quality and to identify the degradation types. The results were compared with similar tests on recently-cut oak. X-ray photoelectron spectroscopy (XPS) revealed the presence of more lignin-related peaks in the archaeological oak, which likely reflected the …

Role Of Social Network On Technology Adoption: Application To Nebraska Producers In The Face Of Undesirable Vegetation Transitions, Sabrina Gulab, Holly K. Nesbitt, Simanti Banerjee, Theresa Floyd, Karina A. Schoengold

Cornhusker Economics

Conclusion

Producers need to have access to information regarding new conservation practices and technologies to ensure land management in the face of ecological threats in general and vegetation transitions (VTs) in the context of our study. This study investigates the role of an individual producer's social network on the willingness to seek information about technologies and management practices and the likelihood of new technology adoption with special attention to risk attitudes and producer spillover effects. Our results provide evidence that network composition and information obtained through a producer's social network don't influence an individual's willingness to seek information about new …

Avian Community Response To Oak Savanna Management In West Michigan, Abigail Elaine Fischer, Paul W. Keenlance, Alexandra B. Locher, Joseph J. Jacquot

Masters Theses

In the midwestern United States, oak savanna ecosystems have experienced steep declines over the past century due to loss of disturbances and changes in land use. This loss coincides with the decline in avian communities across North American and has negatively impacted taxa that associate with open vegetation cover types. Expanding efforts to restore and manage oak savanna ecosystems has resulted in increased open habitat which has positively impacted these avian communities, resulting in increased species diversity. While numerous studies within the Midwest have observed similar results, there have been no studies in Michigan that have formally assessed the impact …

Editorial: Genetic Validation And Its Role In Crop Improvement, Ahmed Sallam, Ahmad M. Alqudah, P. Stephen Baenziger, Awais Rasheed

Department of Agronomy and Horticulture: Faculty Publications

Gene discovery for economically important traits has remained a challenging Frontier in crop genomics and breeding. The recent advances in DNA sequencing technologies and genetic analysis approaches paved the way for discovering many genes and hotspot genomic regions controlling target traits. The detection of novel genomic regions or candidate genes is very useful for plant breeders and geneticists to improve crops, dissect the genetics of complex traits, and understand the biological mechanisms of genes underpinning traits of interest. Quantitative trait loci (QTL) mapping and genome-wide association studies (GWAS) dominated recent crop gene discovery research. These studies are becoming routine activities …

Transfer Effects Of A Multiple-Joint Isokinetic Eccentric Resistance Training Intervention To Nontraining-Specific Traditional Muscle Strength Measures, Steven Spencer, Brennan J. Thompson, Eadric Bressel, Talin Louder, David C. Harrell

Kinesiology and Health Science Faculty Publications

Relatively few investigations have examined the transfer effects of multiple-joint isokinetic eccentric only (MJIE) resistance training on non-specific measures of muscle strength. This study investigated the transfer effects of a short-term MJIE leg press (Eccentron) resistance training program on several non-specific measures of lower-body strength. Fifteen participants performed Eccentron training three times/week for four weeks and were evaluated on training-specific Eccentron peak force (EccPF), nontraining-specific leg press DCER one-repetition maximum (LP 1 RM), and peak torques of the knee extensors during isokinetic eccentric (Ecc30), isokinetic concentric (Con150) and isometric (IsomPT) tasks before and after the training period. The training elicited …

Inter-Seasonal Comparison Of Acoustic Propagation In A Thalassia Testudinum Seagrass Meadow In A Shallow Sub-Tropical Lagoon, Kevin M. Lee, Megan S. Ballard, Andrew R. Mcneese, Preston S. Wilson, Gabriel R. Venegas, Mathew C. Zeh, Abdullah Rahman

School of Earth, Environmental, & Marine Sciences Faculty Publications

Acoustic propagation measurements were collected in a seagrass meadow in a shallow lagoon for periods of over 65 h in winter and 93 h in summer. A bottom-deployed sound source transmitted chirps (0.1–100 kHz) every 10 min that were received on a four-receiver horizontal hydrophone array. Oceanographic probes measured various environmental parameters. Daytime broadband acoustic attenuation was 2.4 dB greater in summer than winter, and the median received acoustic energy levels were 8.4 dB lower in summer compared to winter. These differences were attributed in part to seasonal changes in photosynthesis bubble production and above-ground seagrass biomass.

Inter-Seasonal Comparison Of Acoustic Propagation In A Thalassia Testudinum Seagrass Meadow In A Shallow Sub-Tropical Lagoon, Kevin M. Lee, Megan S. Ballard, Andrew R. Mcneese, Preston S. Wilson, Gabriel R. Venegas, Mathew C. Zeh, Abdullah Rahman

School of Earth, Environmental, & Marine Sciences Faculty Publications

Acoustic propagation measurements were collected in a seagrass meadow in a shallow lagoon for periods of over 65 h in winter and 93 h in summer. A bottom-deployed sound source transmitted chirps (0.1–100 kHz) every 10 min that were received on a four-receiver horizontal hydrophone array. Oceanographic probes measured various environmental parameters. Daytime broadband acoustic attenuation was 2.4 dB greater in summer than winter, and the median received acoustic energy levels were 8.4 dB lower in summer compared to winter. These differences were attributed in part to seasonal changes in photosynthesis bubble production and above-ground seagrass biomass.

Balancing Renewable Energy And River Resources By Moving From Individual Assessments Of Hydropower Projects To Energy System Planning, Jeffrey J. Opperman, Juan Pablo Carvallo, Rafael Kelman, Rafael J. P. Schmitt, Rafael M. Almeida, Emily Chapin, Alexander Flecker, Marc Goichot, Guenther Guenther Grill, Julien J. Harou

School of Earth, Environmental, & Marine Sciences Faculty Publications

As governments and non-state actors strive to minimize global warming, a primary strategy is the decarbonization of power systems which will require a massive increase in renewable electricity generation. Leading energy agencies forecast a doubling of global hydropower capacity as part of that necessary expansion of renewables. While hydropower provides generally low-carbon generation and can integrate variable renewables, such as wind and solar, into electrical grids, hydropower dams are one of the primary reasons that only one-third of the world’s major rivers remain free-flowing. This loss of free-flowing rivers has contributed to dramatic declines of migratory fish and sediment delivery …

The Intertwining Of Zn-Finger Motifs And Abiotic Stress Tolerance In Plants: Current Status And Future Prospects, Debojyoti Moulick, Karma Landup Bhutia, Sukamal Sarkar, Anirban Roy, Udit Nandan Mishra, Biswajit Pramanick, Sagar Maitra, Tanmoy Shankar, Swati Hazra, Milan Skalicky, Marian Brestic, Viliam Barek, Akbar Hossain

Department of Agronomy and Horticulture: Faculty Publications

Environmental stresses such as drought, high salinity, and low temperature can adversely modulate the field crop’s ability by altering the morphological, physiological, and biochemical processes of the plants. It is estimated that about 50% + of the productivity of several crops is limited due to various types of abiotic stresses either presence alone or in combination (s). However, there are two ways plants can survive against these abiotic stresses; a) through management practices and b) through adaptive mechanisms to tolerate plants. These adaptive mechanisms of tolerant plants are mostly linked to their signalling transduction pathway, triggering the action of plant …

Obesity Is Associated With Altered Tumor Metabolism In Metastatic Melanoma, Andrew W Hahn, Ashley V Menk, Dayana B Rivadeneira, Ryan C Augustin, Mingchu Xu, Xiaogang Wu, Tuba N Gide, Camelia Quek, Yan Zang, Christine N Spencer, Alexander M Menzies, Carrie R Daniel, Courtney W Hudgens, Theodore Nowicki, Lauren E Haydu, M A Wadud Khan, Vancheswaran Gopalakrishnan, Elizabeth M Burton, Jared Malke, Julie M Simon, Chantale Bernatchez, Nagireddy Putluri, Scott E Woodman, Y N Vashisht Gopal, Renato Guerrieri, Grant M Fischer, Jian Wang, Khalida M Wani, John F Thompson, Jeffrey E Lee, Patrick Hwu, Nadim Ajami, Jeffrey E Gershenwald, Georgina V Long, Richard A Scolyer, Michael T Tetzlaff, Alexander J Lazar, Dirk Schadendorf, Jennifer A Wargo, John M Kirkwood, Ralph J Deberardinis, Han Liang, Andrew Futreal, Jianhua Zhang, James S Wilmott, Weiyi Peng, Michael A Davies, Greg M Delgoffe, Yana G Najjar, Jennifer L Mcquade

Faculty, Staff and Student Publications

PURPOSE: Overweight/obese (OW/OB) patients with metastatic melanoma unexpectedly have improved outcomes with immune checkpoint inhibitors (ICI) and BRAF-targeted therapies. The mechanism(s) underlying this association remain unclear, thus we assessed the integrated molecular, metabolic, and immune profile of tumors, as well as gut microbiome features, for associations with patient body mass index (BMI).

EXPERIMENTAL DESIGN: Associations between BMI [normal (NL < 25) or OW/OB (BMI ≥ 25)] and tumor or microbiome characteristics were examined in specimens from 782 patients with metastatic melanoma across 7 cohorts. DNA associations were evaluated in The Cancer Genome Atlas cohort. RNA sequencing from 4 cohorts (n = 357) was batch corrected and gene set enrichment analysis (GSEA) by BMI category was performed. Metabolic profiling was conducted in a subset of patients (x = 36) by LC/MS, and in flow-sorted melanoma tumor cells (x = 37) and patient-derived melanoma cell lines (x = 17) using the Seahorse XF assay. Gut microbiome features were examined in an independent cohort (n = 371).

RESULTS: DNA mutations and copy number variations were not associated with BMI. GSEA demonstrated that tumors from OW/OB patients were metabolically quiescent, with downregulation of oxidative phosphorylation and multiple other metabolic pathways. Direct metabolite analysis and functional metabolic profiling confirmed decreased …

Molecular Mechanisms And Future Implications Of Vegf/Vegfr In Cancer Therapy, Sonia A Patel, Monique B Nilsson, Xiuning Le, Tina Cascone, Rakesh K Jain

Faculty, Staff and Student Publications

Angiogenesis, the sprouting of new blood vessels from existing vessels, is one of six known mechanisms employed by solid tumors to recruit blood vessels necessary for their initiation, growth, and metastatic spread. The vascular network within the tumor facilitates the transport of nutrients, oxygen, and immune cells and is regulated by pro- and anti-angiogenic factors. Nearly four decades ago, VEGF was identified as a critical factor promoting vascular permeability and angiogenesis, followed by identification of VEGF family ligands and their receptors (VEGFR). Since then, over a dozen drugs targeting the VEGF/VEGFR pathway have been approved for approximately 20 solid tumor …

Treatment Strategies And Mechanisms Associated With The Prevention Of Nash-Associated Hcc By A Toll-Like Receptor 4 Inhibitor, Suet-Ying Kwan, Alyssa N Slayden, Aubrey R Coronado, Rosamaria C Marquez, Huiqin Chen, Michelle I Savage, Jennifer T Fox, Shizuko Sei, Dong Liang, Heather L Stevenson, Gregory K Wilkerson, Mihai Gagea, Powel H Brown, Laura Beretta

Faculty, Staff and Student Publications

UNLABELLED: We evaluated the cancer preventive efficacy of TAK-242, an inhibitor of Toll-like receptor 4 (TLR4), in a mouse model of hepatocellular carcinoma (HCC) occurring in the context of nonalcoholic steatohepatitis (NASH). We also assessed the cellular events associated with the preventive treatment efficacy. We tested oral administration of TAK-242, at clinically relevant but toxicity-reducing doses and scheduling, in mice with hepatocyte-specific deletion of Pten (HepPten-). The optimal dose and oral gavage formulation of TAK-242 were determined to be 30 mg/kg in 5% DMSO in 30% 2-hydroxypropyl-β-cyclodextrin. Daily oral administration of 30 mg/kg TAK-242 over 18 weeks was well tolerated …

Phase I Dose Escalation Study Of Topical Bexarotene In Women At High Risk For Breast Cancer, Parijatham S Thomas, Anisha B Patel, J Jack Lee, Diane D Liu, Mike Hernandez, Alejandro Contreras, Carrie Mays, Diane Weber, Lana A Vornik, Seema A Khan, Eileen Dimond, Brandy M Heckman-Stoddard, Marjorie Perloff, Powel H Brown

Faculty, Staff and Student Publications

Bexarotene is a rexinoid that has been shown to prevent mammary tumors in mouse models but oral dosing has toxicities. This phase I study evaluates topical bexarotene, as a potential chemoprevention agent, for safety and toxicity in high-risk women for breast cancer.

Bending The Patient Safety Curve: How Much Can Ai Help?

Faculty, Staff and Student Publications

This paper reviews the current state of patient safety and the application of artificial intelligence (AI) techniques to patient safety. This paper defines patient safety broadly, not just inpatient care but across the continuum of care, including diagnostic errors, misdiagnosis, adverse events, injuries, and measurement issues. It outlines the major current uses of AI in patient safety and the relative adoption of these techniques in hospitals and health systems. It also outlines some of the limitations of these AI systems and the challenges with evaluation of these systems. Finally, it outlines the importance of developing a proactive agenda for AI …