Life Sciences Commons^™

Mechanometabolism Instructs Hematopoietic Stem Cell Specification, Paulina D Horton, Alina Syed, Michelle Winkler, Abishek B Vaidya, Michael Rariden, Neha Arora, Yong Zhou, Michihiro Kobayashi, Momoko Yoshimoto, Hyun Jung Lee, Hyun-Eui Kim, John P Hagan, Catherine Denicourt, Travis I Moore, Pamela L Wenzel

Faculty, Staff and Student Publications

Mechanical force generated by blood flow stimulates emergence of the first hematopoietic stem cells (HSCs) that populate the blood system. Force drives the transition of HSC precursors from an endothelial to hematopoietic identity, yet the molecular regulation of this fate switch remains poorly understood. We report that shear stress triggers adaptation in mitochondrial composition, ultrastructure, and function, which are essential for hematopoietic fate and engraftment potential. Shear stress remodels mitochondria in hemogenic endothelium by promoting mitochondrial gene transcription and protein synthesis. Laminar flow selectively initiates translation of 5' terminal polypyrimidine (5'TOP) motif-containing transcripts, which commonly encode ribosome and translation machinery. …

Poly(Adp-Ribose) Glycohydrolase Enforces P21 Degradation Via Deparylation To Promote Gastric Cancer Progression, Yangchan Hu, Qimei Bao, Yixing Huang, Yan Wang, Xin Zhao, Junjun Nan, Yuxin Meng, Mingcong Deng, Yuancong Li, Zirui Zhuang, Hanyi He, Dan Zu, Yuke Zhong, Chunkai Zhang, Bing Wang, Ran Li, Yanhua He, Qihan Wang, Min Liu, John A Tainer, Yin Shi, Xiangdong Cheng, Ji Jing, Zu Ye

Faculty, Staff and Student Publications

Dysregulation of cell cycle checkpoints is a cancer hallmark, with ubiquitination-controlled protein stability playing a pivotal role. Although p21, a key cyclin-dependent kinase inhibitor, is tightly regulated by ubiquitin-mediated degradation, the key upstream modulators of its ubiquitination remain incompletely defined. Here, we identify poly(ADP-ribose) glycohydrolase (PARG) as a regulator of p21 stability in gastric cancer (GC) cells. We show that PARG expression is markedly upregulated in GC tissues and correlates with poor patient prognosis. Functional assays revealed that genetic depletion of PARG triggers G2/M phase arrest and impairs GC cell proliferation. Mechanistically, we demonstrate that PARG loss enhances p21 PARylation, …

Dna Methylation Is Associated With Von Willebrand Factor And Coagulation Factor Viii Plasma Levels: The Atherosclerosis Risk In Communities Study, Julie Hahn, Jan Bressler, Myriam Fornage, Eric Boerwinkle, Nicholas L Smith, Alanna C Morrison, Paul S De Vries

Faculty, Staff and Student Publications

Background: Limited information is available on how DNA methylation of cytosine-phosphate-guanine (CpG) sites across the genome regulate circulating von Willebrand Factor (VWF) and factor VIII (FVIII) levels.

Methods: We performed an epigenome-wide association study to examine the association of leukocyte DNA methylation levels at 483,735 CpG sites with VWF antigen plasma levels and FVIII activity in 2,597 Black and 1,011 White participants from the Atherosclerosis Risk in Communities (ARIC) study. VWF antigen levels and FVIII activity were measured at the baseline exam, while DNA methylation was measured with the Infinium HumanMethylation450 BeadChip array at visit 2 or 3. Discovery analysis …

Ectopic B Lymphocyte Follicles Exacerbate Ischemic Brain Damage Via Mif-Cd74/Cxcr4 And Interferon Signaling, Sheng Yang, Hang Zhang, Lu-Lu Xu, Luo-Qi Zhou, Yun-Hui Chu, Lian Chen, Xiao-Wei Pang, Lu-Yang Zhang, Li-Fang Zhu, Ming-Hao Dong, Ke Shang, Jun Xiao, Long-Jun Wu, Wei Wang, Dai-Shi Tian, Chuan Qin

Faculty, Staff and Student Publications

Neuroinflammation, encompassing both innate and adaptive immune responses, plays a crucial role in ischemic stroke. Although B lymphocytes are central to adaptive immunity, their contributions to ischemic stroke remain poorly understood. Here, we demonstrated that B lymphocytes accumulate in ischemic lesions, forming germinal center-like structures at the later stage after stroke, which mainly depended on in situ proliferation. This accumulation correlated with worsened neuroinflammation and ischemic injury, whereas B cell depletion reduced chronic brain damage during stroke. Mechanistically, microglia recruited B cells into ischemic lesions through MIF-CD74/CXCR4 signaling during the early phase of stroke, while IFN-related pathways in B cells …

Sustainable Aviation Fuel (Saf) From Used Cooking Oil (Uco) In Egypt: Opportunities And Challenges., Lamiaa Abdallah

Mansoura Engineering Journal

Global aviation sector contributes nearly 2.5% of global CO2 emissions. Aviation is hard-to-decarbonize sector due to the high energy densities required for aircraft. Commercial aviation is fueled by kerosene-based jet fuel. Alternatives for this carbonbased fuel include electric batteries, hydrogen fuel, and SAF. Electric batteries have very low energy densities. Hydrogen would require a complete change of the aviation system, including fuel & airport infrastructure. SAF is the only viable option in the short to medium term. SAF is produced from sustainable feed-stocks (like agricultural oils), with no embodied carbon. Existing airplanes can use traditional fuel blended with up to …

The Need For Developing Psychologically Informed Physical Therapy Education, Dustin Cox

Journal of Applied Disciplines

Chronic pain presents a multifaceted challenge for healthcare providers, often impacting patients' physical, emotional, and psychological well-being. Research indicates that individuals with chronic pain process pain through emotional and reward pathways in the brain, underscoring the need for integrative treatment approaches. Evidence supports the effectiveness of combining psychological interventions with physical rehabilitation to improve outcomes. Acceptance and Commitment Therapy (ACT), a mindfulness-based behavioral therapy, has shown promise in addressing the psychological dimensions of chronic pain. However, physical therapists often lack formal training in ACT. This study protocol was designed to explore effective methods for educating physical therapists in ACT principles …

Plaster Creek Watershed Management Plan: Chloride Addendum, Plaster Creek Stewards

Watershed Reports

This addendum complements the 2008 Plaster Creek Watershed Management Plan (WMP), which tells the full story of the Plaster Creek Watershed’s current condition, impairments, and need for restoration. This addendum focuses on chloride, an emerging pollutant of concern in Michigan that was not addressed in Plaster Creek’s 2008 WMP. This addendum meets the nine elements required by the United States Environmental Protection Agency (EPA) for a watershed management plan to be officially approved; as such, its content and layout are intended for a technical audience.

Anaemic Streams: Iron And Essential Trace Metals Frequently Limit Primary Producer Biomass, David M. Costello, Olufemi J. Akinnifesi, Renn C. Schipper, Paisley Kostick, Jordyn T. Stoll, Scott D. Tiegs, Amy Marcarelli, Sally A. Entrekin, Raven L. Bier, Krista A. Capps, Dean E. Fletcher

Michigan Tech Publications

Metals are essential for microbial metabolism, yet their role as limiting nutrients in freshwater streams remains poorly understood. We quantified the prevalence of metal and nutrient (co-)limitation of primary producers in 41 streams. Metal limitation was widespread with Fe limitation eliciting the strongest and most consistent biomass responses (50% of streams). Zn limitation was also common (33% of streams), marking the first evidence of Zn-limited stream biofilms at this spatial scale. Metals were often co-limiting with N and P, highlighting interactions between macro- and micronutrients. Diatoms were more responsive to Zn and cyanobacteria reached higher biomass with N and P …

(Si16-21) Dynamical Study Of A Hassell-Varley Model With Nonlinear Harvesting And Fear Effect In Prey, Aditya Bhattacharya, Anindita Bhattacharyya

Applications and Applied Mathematics: An International Journal (AAM)

In this article, a one predator-one prey model incorporating Richards’ type growth in prey population, Hassell-Varley type functional response and Michaelis-Menten type prey harvesting is proposed and analyzed. Richards’ type growth with fear factor is incorporated in the proposed model to generalize the reduction effect of predator-induced fear on the rate of growth of the prey population. Positivity and boundedness of the system’s solutions are first established to ensure biological feasibility of the model. Existence and stability conditions of various types of equilibrium points associated with the model such as trivial equilibrium, axial (predator–free) equilibrium and coexistence equilibrium are obtained …

Circuit And Synaptic Mechanisms Of Methamphetamine Induced Cognitive Deficits During Abstinence: Roles Of The Perirhinal-Prefrontal Pathway And The Nucleus Reuniens, Sarah Goldsmith

MUSC Theses and Dissertations

Cognitive deficits during abstinence are a hallmark of methamphetamine (meth) use and indicative of negative treatment outcomes. In rats, both long access meth self-administration and meth binge produce recognition memory deficits due to drug-induced plasticity within the perirhinal cortex (PRH). PRH projections are numerous and include the medial prefrontal cortex (mPFC) and the Nucleus Reuniens (NRe). In the first study, the role of the PRH-mPFC reciprocal circuit in novel object recognition memory was investigated by infusing an rgAAV encoding GFP-tagged Cre recombinase into the PRH or the mPFC. Following surgery, rats explored objects. During exploration, PRH neurons receiving input from …

Stemflow Dynamics In The Jamari National Forest (Brazilian Amazon): Ii. Solute Concentrations And Flux Dynamics, Jeferson Alberto De Lima, John T. Van Stan Ii, Karolina Lewińska, Agnieszka Dradrach, Jakub Ceglarek, Kelly Cristina Tonello

Biological, Geological, and Environmental Faculty Publications

Trees can redirect large volumes of rainwater to the base of their stems. This stemflow not only redistributes water but also channels canopy-derived solutes to the forest floor. Building on research showing canopy geometry and bark properties govern stemflow volumes, we examined how those same traits modulate the biogeochemical side of this flux. Over a 12-month period in Jamari National Forest (Brazil), we quantified stemflow volume and solute chemistry for 19 trees grouped by diameter at breast height (D: < 10, 10-20 and > 20 cm), crown area (CA: < 30, 30-60 and > 60 m(2)) and bark texture (smooth, fissured and rough). Small-stemmed, smooth-barked trees produced the greatest stemflow …

Alfred Russel Wallace Notes 39. What About Wallace's 'Agnosticism'...?, Charles H. Smith

Faculty/Staff Personal Papers

Alfred Russel Wallace (1823−1913) seems to have distinguished his earlier years of agnosticism from his later period as a spiritualist, but a closer look at the situation suggests he actually remained an agnostic all the way through to the end of his life. The confusion is occasioned by a lack of terminology that can be applied to his position, which most closely resembles a Spinozian manner of thinking.

Differential Effects Of Neighborhood Ambient Pm2.5 Exposure And Social Vulnerability On Cancer-Related Systemic Inflammation By Race In A Large Health Care System Population From 2000 To 2020, Benjamin A. Rybicki, Zihan Lin, Amber L. Pearson

Biological, Geological, and Environmental Faculty Publications

BackgroundThe environment can impact cancer risk both directly, such as through the air we breathe, and indirectly, through the neighborhoods we live in. These risk factors often work in concert but can have disparate effects.MethodsTo understand how air pollution, as measured by ambient particulate matter 2.5 (PM2.5) levels and neighborhood disadvantage based on a geographically assigned social vulnerability index (SVI), may act together to impact cancer risk, we used 2000-2020 statewide cohort data from a large health system based in metropolitan Detroit, MI, USA (n = 245,438). Systemic inflammation was used as a surrogate indicator of cancer risk among study …

A Bacillus Pumilus Isolate With Promising Antimycobacterial Properties, Cody M. Pfaff

SACAD: Scholarly Activities

The emergence of multidrug-resistant bacterial pathogens, particularly Mycobacterium tuberculosis, highlights the urgent need for new antimicrobial agents. Tuberculosis remains one of the world’s deadliest infectious diseases, claiming over a million lives annually and posing increasing challenges due to the thick, lipid-rich, acid-fast cell wall of Mycobacterium species that renders them naturally resistant to many antibiotics. In this study, a soil sample collected from the Campus of Fort Hays State University yielded a bacterial isolate exhibiting strong antimicrobial activity. Initial screening against Escherichia coli MM294 showed a 10 mm inhibition zone, and subsequent testing identified the isolate as Bacillus pumilus …

In Vitro Pharmacological Evaluation Of Novel Cmpi Derivatives As Selective Positive Allosteric Modulators Of The Alpha4 Beta2 Nicotinic Acetylcholine Receptor, Josue Gaona, Nataly Sanchez, Wilder Felix, Nathalia Menegasso, Brisa Cea, Ganesh Thakur, Ayman K. Hamouda

School of Medicine Student Publications and Presentations

Nicotinic acetylcholine receptors (nAChRs) contribute to the pathogenesis of neurodegenerative diseases such as Parkinson’s disease (PD), where degeneration of dopaminergic and cholinergic neurons disrupts neurotransmission. The (α4)₃(β2)₂ nAChR subtype is expressed on affected neuronal populations and represents a promising therapeutic target. Positive allosteric modulators (PAMs) may enhance receptor function while preserving endogenous signaling. We evaluated chemical derivatives of CMPI [3-(2-chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)isoxazol] as selective PAMs of (α4)₃(β2)₂ nAChRs. Two-electrode voltage-clamp recordings were performed in Xenopus laevis oocytes expressing defined receptor stoichiometries to assess potentiation and generate dose–response curves. Cytotoxicity was assessed in HEK cells using the MTT assay. Substitutions at the pyrazole …

Segmental Tracheal Resection For Thyroid Cancer: Perioperative Morbidity, Locoregional Control, And Survival, Anastasios Maniakas, David C Wilde, Isabelle Fournier, Emily K Hyde, Li Xu, Jennifer R Wang, Neil D Gross, Erich M Sturgis, Victoria Banuchi, Naifa L Busaidy, Maria E Cabanillas, Priyanka Iyer, Ramona Dadu, Steven G Waguespack, Mimi I Hu, G Brandon Gunn, Michael Kwon, Salmaan Ahmed, Michelle D Williams, Mark E Zafereo

Faculty, Staff and Student Publications

Background: Segmental tracheal resection is rarely needed for advanced thyroid cancer but is among the most complex, high-risk thyroid surgeries.

Methods: Retrospective study of patients undergoing segmental tracheal resection for thyroid cancer at MD Anderson Cancer Center (2005-2024).

Results: We identified 120 patients with a median follow-up of 4.6 years (range 0.02-16.38). Papillary thyroid cancer was most common (68%). The median number of tracheal rings resected was 4 (range 1-9). Seventeen (14%) patients had a new tracheostomy placed at the time of surgery, with 11 (9%) remaining trach-dependent at last follow-up. Twenty-six (22%) patients had a return to the operating …

Ferroptosis As A Pathological Driver In Niemann-Pick Disease Type C, Kayla Linda Sanchez

Loma Linda University Electronic Theses, Dissertations & Projects

Niemann–Pick Disease Type C (NPC) is a hereditary neurodegenerative disease characterized by selective cell vulnerability, particularly affecting cerebellar anterior Purkinje neurons. These neurons exhibit a distinctive pattern of degeneration due to the loss of NPC1 and/or NPC2 protein function, progressively extending towards posterior cerebellar regions. Historically, research has described NPC as a disorder of intracellular cholesterol handling; however, cholesterol-lowering therapies have not effectively prevented neurological deterioration, and the mechanisms underlying selective neuronal vulnerability remain unclear. Ferroptosis, previously referred to as oxytosis, is a regulated form of cell death driver by iron-induced lipid peroxidation. It has been implicated in several neurodegenerative …

The Emerging And Evolving Evidence Supporting Creatine As An Ergogenic Aid: History And Applications, Chad Kerksick, Drew Gonzalez, Jeffrey Stout, Scott Forbes, Darren Candow, Tim Ziegenfuss, Ronald Marshall, René Schwesig, Richard Kreider

Faculty Scholarship

Background

Creatine is one of the most extensively studied ergogenic aids, with over three decades of research supporting its role in exercise performance, recovery, and health.

Methods

This narrative review summarizes the historical development of creatine supplementation and evaluates evidence regarding its mechanisms, efficacy across active, athletic populations (e.g. strength, endurance, team-sport), and tactical (e.g. military, law enforcement) populations, and its safety profile.

Results

The evidence suggests that creatine enhances phosphocreatine resynthesis and cellular energy availability, resulting in consistent improvements in high-intensity exercise performance, training adaptations, lean body mass, strength, and power. Additional findings indicate that creatine may attenuate exercise-induced …

College Of Natural Sciences 2025 Year-End Publication, College Of Natural Sciences

College of Natural Sciences Newsletters and Reports

Page 2 Dean's Message 
Page 3 Department Highlights 
Page 4 One Day for State 
Page 5 Ice cores reveal volcanic eruptions in 13th century 
Page 5 How do our cells interpret stress 
Page 6-7 Faculty Excellence
Page 8 New chemical biology consortium will accelerate cancer research
Page 9 SDSU to combat crop disease, biofilms in new NSF-back project 
Page 9 Science as Art Competition 
Page 10-11 Student Excellence  
Page 12 SDSU researcher developing natural alternative to synthetic dyes
Page 12 Browning Retired
Page 13 Quantum technologies through NSF-backed project
Page 13 NASA Funds CNS Development of Model
Page 14 GGS …

Improvements To Fisheries Compensation Processes And Valuation Methodologies In Western Australia, Department Of Primary Industries And Regional Development, Western Australia

Fisheries Published Reports

This report has been prepared by the Compensation Working Group (WG) to provide advice to the Minister for Fisheries on improving Western Australia’s (WA) fisheries compensation processes under two key legislative frameworks:

• Fisheries adjustment schemes, under the Fisheries Adjustment Scheme Act 1987
• (FAS Act), and 
• Statutory compensation under Fishing and Related Industries Compensation (Marine Reserves) Act 1997 (FRICMA).

This work has been undertaken as a precursor to the larger scale adjustment and compensation processes that will be required as part of the implementation of several marine parks throughout the Kimberley and South Coast of WA.

Fisheries Occasional Publication No. 150 - Response To 2024 External Review Of Integrated Stock Assessments For Key Wa Demersal Indicator Stocks, Rubie Evans-Powell, S. A. Hesp, Ainslie Denham, Emily A. Fisher, Rachel Marks, Fabian I. Trinnie, Brett Crisafulli

Fisheries Occasional Publications

In Western Australia (WA), stock assessments for key demersal species, including snapper and red emperor, have traditionally used bespoke integrated models developed in-house by the Department of Primary Industries and Regional Development (DPIRD). In line with other Australian jurisdictions, DPIRD is transitioning to Stock Synthesis (SS) as its primary platform for integrated stock assessments of WA finfish. To support this transition, DPIRD commissioned an independent expert review of recent integrated models applied to three demersal stocks. This publication responds to recommendations from Professor André Punt (University of Washington and CSIRO) in his 2024 review, which examined assessments for Pilbara red …

Vertical Price Transmission In The Philippine Rice Supply Chain: Responses To Shocks In The Post-Tariffication Period, Bates Bathan

The Philippine Agricultural Scientist

In the post-Rice Tariffication Law (RTL) period, several protectionist policies and state interventions have reemerged in the Philippine rice market. Using national-level time series data from January 2018 to April 2025, the study applies autoregressive distributed lag models to assess the impact of policy changes and external shocks on unmilled rice (palay) and rice prices. Results show that National Food Authority (NFA) rice stocks significantly affect palay farmgate prices and special rice retail prices. Vertical price transmission flows from farmgate to wholesale levels for special rice, and from wholesale to retail levels for well-milled and regular-milled rice. Major …

The Dual Nature Of Weedy Rice (Oryza Sativa F. Spontanea): From A Noxious Weed To An Important Genetic Resource For Rice Improvement, Rica M. Rentino, Vanessa Sernicula, May O. Palanog, Roselyn G. Alfetche, Dan Michael A. Angay, Francis L. Tejada, Dexter G. Balboa, Shaireen M. Angay, Fatima-Nasra A. Sahadain, Teodora E. Mananghaya, Karl Vincent J. Jose, Liezel C. Llanes, Jonathan M. Niones, Karla Mae R. Nonog, Frodie F. Waing, Leonilo Gramaje, Albert Christian S. Suner, Ommal H. Abdulkadi, Norvie L. Manigbas, Jose E. Hernandez, Alvin D. Palanog

The Philippine Agricultural Scientist

Weedy rice (Oryza sativa f. spontanea) is becoming a serious threat to rice production in the Philippines, especially in direct-seeding rice areas, owing to its high competitiveness and its similarity to cultivated rice in morphology and ecological requirements. However, weedy rice can be considered both a threat that endangers rice production and an opportunity, as it offers a potential source of novel genes for rice improvement. This study evaluated the extent of weedy rice infestation in direct-seeding areas in the Visayas, measured the phenotypic and genotypic diversity of collected weedy rice ecotypes using simple sequence repeat (SSR) markers, and …

Improvement Of Forage Productivity By Intercropping Pakchong 1 And Napier Grass With Mungbean And Soybean In Los Baños, Laguna, Philippines, Paul Joshua C. Marquez, Eureka Teresa M. Ocampo, Menandro M. Loresco, Lourdes S. Edano Ma, Agapita J. Salces

The Philippine Agricultural Scientist

Forage demand is rising in the Philippines, and to sustainably boost agronomic performance, the beneficial impact of intercropping was investigated. This study characterized the performance of high-yielding forages, namely Napier grass (NG) and Pakchong 1 (PK), when intercropped with soybean (SB) and mungbean (MB) under rain-fed conditions in Los Banos, Laguna. The experiment was conducted in a repeated-measures RCBD replicated 3 times with grass species and cropping system as main factors, resulting in the following treatment combinations: Sole NG, Sole PK, NGSB, NGMB, PKSB, and PKMB. Grasses were ratooned, legumes were harvested, and legume seeds were re-sown every 45 to …

Women’S Roles In Philippine Agriculture In The Context Of Climate Change: A Meta-Synthesis Using The Gender Analysis Framework, Gemnmalyn M. Trespalacio, Nico Jayson C. Anastacio, Samantha Geraldine G. De Los Santos

The Philippine Agricultural Scientist

This paper highlights the critical role of women, including their contribution to adapting to the effects of climate change on the Philippine agriculture sector. It provides an overview of women’s roles in agriculture in the context of climate change through the lens of the Gender Analysis Framework (GAF). A total of 1,823 relevant articles were collected from ScienceDirect, adopting the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. After 2 levels of screening process, 17 articles were synthesized guided by the domains of GAF: (1) access to assets; (2) practices and participation; (3) beliefs and perception; and (4) …

Improvement Of Forage Productivity By Intercropping Pakchong 1 And Napier Grass With Mungbean And Soybean In Los Baños, Laguna, Philippines, Paul Joshua C. Marquez, Eureka Teresa M. Ocampo, Menandro M. Loresco, Ma Lourdes S. Edano, Agapita J. Salces

The Philippine Agricultural Scientist

Forage demand is rising in the Philippines, and to sustainably boost agronomic performance, the beneficial impact of intercropping was investigated. This study characterized the performance of high-yielding forages, namely Napier grass (NG) and Pakchong 1 (PK), when intercropped with soybean (SB) and mungbean (MB) under rain-fed conditions in Los Banos, Laguna. The experiment was conducted in a repeated-measures RCBD replicated 3 times with grass species and cropping system as main factors, resulting in the following treatment combinations: Sole NG, Sole PK, NGSB, NGMB, PKSB, and PKMB. Grasses were ratooned, legumes were harvested, and legume seeds were re-sown every 45 to …

Heterosis For Flowering Time And Leaf Traits In F1 Hybrids From Desi And Kabuli Chickpeas [Research Note], Gizem Kamçi, Behiye Tuba Biçer

The Philippine Agricultural Scientist

The study was conducted at the Faculty of Agriculture in Dicle University, Southeast Anatolia, Türkiye, during the 2023 growing season to estimate heterosis, heterobeltiosis, and dominance for phenological, leaf, and plant traits in F₁ hybrids from desi × kabuli and kabuli × kabuli chickpea crosses. In 2022, 2 desi (Black, ICCV 10) and 3 kabuli (Azkan, ILC 533, ILC 482) chickpea varieties were crossed, producing 10 hybrids and 5 parents evaluated in a randomized complete block design with 3 replications. Significant variation was found among genotypes for all traits. Days to first flowering ranged from 55.7 to 69.0 d, with …

Beta-Casomorphin7 Detection In Milk From Dairy Species And Beta-Casein Protein Characterization In Cattle From Selected Provinces In The Philippines, Angelo M. Tapia, Cynthia R. Oliveros Maria, Queennie Hope D. Umipon, Hazel Marie E. Nicolas, Naoya Ogawa, Yasuyuki Kitaura

The Philippine Agricultural Scientist

This study was conducted to detect β-casomorphin7 (BCM7) in dairy animals and to characterize the β-casein (CSN2) genotype among dairy cattle breeds in the Philippines. A total of 59 dairy animals, composed of 35 cattle (12 Holstein Sahiwal [HS16 Jersey × Holstein Friesian [JHF], and 7 Siquijor Native Cattle [SNC]), 15 buffaloes (Bulgarian Murrah and Brazilian Murrah), and 9 goats (Saanen and Anglo-Nubian) were collected with milk samples. Milk protein was extracted and subjected to high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) analysis after stimulated gastrointestinal digestion. BCM7 was detected in cattle with an average concentration of 0.322 + 0.080, whereas …

Characterization And Response To Exercise Training Of Hdl-Specific Phospholipid Efflux, Eric C. Leszcynski, Charles S. Schwartz, Kiani J.C. Jacobs, Prasun L. Dev, Sujoy Ghosh, Jeremy M. Robbins, Robert E. Gerszten, Anand Rohatgi, Timothy S. Collier, Robert J. Konard, Masaki Sato, Rafael Zubirán, Claude Bouchard, Edward B. Neufeld, Alan T. Remaley, Mark A. Sarzynski Facsm

Faculty Publications

The HDL-specific phospholipid efflux (HDL-SPE) assay is a novel cell-free measure of HDL function that is inversely associated with coronary artery disease. However, the effect of exercise training on HDL-SPE is unknown. The purpose of this study was to examine the effect of exercise training on HDL-SPE in a large, diverse cohort free of overt disease. Clinical and functional measures of HDL were taken before and after 20 weeks of endurance exercise training in 508 participants from the HERITAGE Family Study. Associations of HDL-SPE with HDL-related traits were examined using Pearson's correlations at baseline and following exercise training (significance: P …

The Dual Nature Of Weedy Rice (Oryza Sativa F. Spontanea): From A Noxious Weed To An Important Genetic Resource For Rice Improvement, Rica M. Rentino, Vanessa Sernicula, May O. Palanog, Roselyn G. Alfetche, Dan Michael A. Angay, Francis L. Tejada, Dexter G. Balboa, Shaireen M. Angay, Fatima-Nasra A. Sahadain, Teodora E. Mananghaya, Karl Vincent J. Jose, Liezel C. Llanes, Jonathan M. Niones, Karla Mae R. Nonog, Frodie F. Waing, Leolilo Gramaje, Albert Christian S. Suner, Ommal H. Abdulkadi, Norvie L. Manigbas, Jose E. Hernandez, Alvin D. Palanog

The Philippine Agricultural Scientist

Weedy rice (Oryza sativa f. spontanea) is becoming a serious threat to rice production in the Philippines, especially in direct-seeding rice areas, owing to its high competitiveness and its similarity to cultivated rice in morphology and ecological requirements. However, weedy rice can be considered both a threat that endangers rice production and an opportunity, as it offers a potential source of novel genes for rice improvement. This study evaluated the extent of weedy rice infestation in direct-seeding areas in the Visayas, measured the phenotypic and genotypic diversity of collected weedy rice ecotypes using simple sequence repeat (SSR) markers, and …