Life Sciences Commons^™

Smokejumper Obituary: Scott, Jonathan Lavon "Scotty" (Mccall 1948), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Chi Sequences Switch The Recbcd Helicase–Nuclease Complex From Degradative To Replicative Modes During The Completion Of Dna Replication, Avery E. Jehru, Charmain Courcelle, Justin Courcelle, Multiple Additional Authors

Biology Faculty Publications and Presentations

Accurately completing DNA replication when two forks converge is essential to genomic stability. The RecBCD helicase–nuclease complex plays a central role in completion by promoting resection and joining of the excess DNA created when replisomes converge. chi sequences alter RecBCD activity and localize with crossover hotspots during sexual events in bacteria, yet their functional role during chromosome replication remains unknown. Here, we use two-dimensional agarose gel analysis to show that chi induces replication on substrates containing convergent forks. The induced replication is processive but uncoupled with respect to leading and lagging strand synthesis and can be suppressed by ter sites …

Developing Improved Water Catchment Systems To Benefit Rangeland Restoration, Ethan Ostraff, Kevin Steele, Ezekiel Jensesn, Matthew Madsen

Library/Life Sciences Undergraduate Poster Competition 2023

1st place open house

Restoring damaged and disturbed lands can be difficult and expensive with increasing drought and changing climatic conditions. Wicking boxes or other irrigation forms can improve restoration efforts' success. These technologies provide a consistent water supply, which often enhances seedling growth and survival in dry conditions. However, current water catchment technologies are limited and often difficult to use. Factors such as production costs, size, and labor needed to install these devices typically make current water catchment technologies inefficient for large-scale use.

Hucopia: An Atlas Of Human Vs. Sars-Cov-2 Interactome And The Comparative Analysis With Other Coronaviridae Family Viruses, Naveen Duhan, Rakesh Kaundal

Plants, Soils, and Climate Faculty Publications

SARS-CoV-2, a novel betacoronavirus strain, has caused a pandemic that has claimed the lives of nearly 6.7M people worldwide. Vaccines and medicines are being developed around the world to reduce the disease spread, fatality rates, and control the new variants. Understanding the protein-protein interaction mechanism of SARS-CoV-2 in humans, and their comparison with the previous SARS-CoV and MERS strains, is crucial for these efforts. These interactions might be used to assess vaccination effectiveness, diagnose exposure, and produce effective biotherapeutics. Here, we present the HuCoPIA database, which contains approximately 100,000 protein-protein interactions between humans and three strains (SARS-CoV-2, SARS-CoV, and MERS) …

Dual-Specificity Phosphatases 22-Deficient T Cells Contribute To The Pathogenesis Of Ankylosing Spondylitis, Ming-Han Chen, Huai-Chia Chuang, Yi-Chen Yeh, Chung-Tei Chou, Tse-Hua Tan

Children’s Nutrition Research Center Staff Publications

Background: Dual-specificity phosphatases (DUSPs) can dephosphorylate both tyrosine and serine/threonine residues of their substrates and regulate T cell-mediated immunity and autoimmunity. The aim of this study was to investigate the potential roles of DUSPs in ankylosing spondylitis (AS).

Methods: Sixty AS patients and 45 healthy controls were enrolled in this study. Associations of gene expression of 23 DUSPs in peripheral T cells with inflammatory cytokine gene expression and disease activity of AS were analyzed. Finally, we investigated whether the characteristics of AS are developed in DUSP-knockout mice.

Results: The mRNA levels of DUSP4, DUSP5, DUSP6, DUSP7, and DUSP14 in peripheral …

Greenbug Feeding-Induced Resistance To Sugarcane Aphids In Sorghum, Heena Puri, Edith Ikuze, Jessica Ayala, Isabella Rodriguez, Rupesh Kariyat, Joe Louis, Sajjan Grover

Department of Entomology: Faculty Publications

Plants are attacked by multiple insect pest species and insect herbivory can alter plant defense mechanisms. The plant defense responses to a specific herbivore may also contribute to the herbivore growth/survival on plants. Feeding by one insect species can modulate the plant defenses, which can either facilitate or hamper the colonization of subsequent incoming insects. However, little is known about the effect of sequential herbivory on sorghum plants. In this study, we demonstrate that a specialist aphid, sugarcane aphid (SCA; Melanaphis sacchari) grows faster on sorghum than a generalist aphid species, greenbug (GB; Schizaphis graminum). We also determined …

Plant Community Patterns And A Flora Of Six Lower Mississippi River Islands, Grace Leia Mccartha

Student Theses and Dissertations

Lower Mississippi River islands experience intense flood regimes that result in a supply of sediment and seeds from upstream. The islands are some of the last remaining floodplain habitats in the Delta region, and surveying their botanical diversity is important for learning about floodplain plant community structure. From June 2020 through December 2021, I conducted a flora of six Lower Mississippi River islands from Helena-West Helena, Arkansas, to Greenville, Mississippi. I collected 2,310 plant specimens for a total of 491 taxa, including five taxa not previously recorded in Arkansas and seven not previously recorded in Mississippi. From mid-July to late-August …

Comparisons Of Small Unmanned Aircraft Systems And Agro-Terrestrial Surveys: Techniques To Determine Field Elevation Surfaces For Improved Crop And Water Management., Richard A. Pickett Jr

Student Theses and Dissertations

Row crop agriculture in Arkansas relies predominantly on groundwater resources for irrigation. This places great demand on the Mississippi River Valley Alluvial Aquifer (MRVAA), which is in a current state of decline. The Eastern Arkansas region produces commodity crops including soybeans, rice, corn, cotton, and peanuts, all of which utilize irrigation for optimal productivity. Conservation practices that reduce groundwater use include precision land leveling, multiple inlet rice irrigation, and computerized hole size selection for furrow irrigation. To collect elevation data to irrigate efficiently, these practices require precision agriculture technology, more specifically Real-Time Kinematic–Global Navigation Satellite Systems (RTK-GNSS). As RTK-GNSS technologies …

Automation Of Irrigation To Improve Outcomes Of Agronomic Crops: On-Farm And Modeling Demonstrations, Thais Murias Jardim

Student Theses and Dissertations

Automated irrigation systems and new management practices may help address aquifer depletion, labor shortages, and irrigation management challenges. This study evaluated the impact of various automated irrigation systems on commercial farms that produce maize, rice, and soybean. It also modeled how Early Cascade Rice Irrigation Shutoff (ECIS) performs under a range of field conditions. Growers observed various benefits of using automated systems other than irrigation savings or yield increase. Timers and remote shutoff are the most practical and beneficial options for growers willing to adopt some level of automation. ECIS modeling estimates showed that applied irrigation and runoff decreased as …

Automated Contouring And Planning In Radiation Therapy: What Is 'Clinically Acceptable'?, Hana Baroudi, Kristy K Brock, Wenhua Cao, Xinru Chen, Caroline Chung, Laurence E Court, Mohammad D El Basha, Maguy Farhat, Skylar Gay, Mary P Gronberg, Aashish Chandra Gupta, Soleil Hernandez, Kai Huang, David A Jaffray, Rebecca Lim, Barbara Marquez, Kelly Nealon, Tucker J Netherton, Callistus M Nguyen, Brandon Reber, Dong Joo Rhee, Ramon M Salazar, Mihir D Shanker, Carlos Sjogreen, Mckell Woodland, Jinzhong Yang, Cenji Yu, Yao Zhao

Faculty, Staff and Student Publications

Developers and users of artificial-intelligence-based tools for automatic contouring and treatment planning in radiotherapy are expected to assess clinical acceptability of these tools. However, what is 'clinical acceptability'? Quantitative and qualitative approaches have been used to assess this ill-defined concept, all of which have advantages and disadvantages or limitations. The approach chosen may depend on the goal of the study as well as on available resources. In this paper, we discuss various aspects of 'clinical acceptability' and how they can move us toward a standard for defining clinical acceptability of new autocontouring and planning tools.

Pearl Millet Response To Drought: A Review, Nikee Shrestha, Hao Hu, Kumar Shrestha, Andrew N. Doust

Department of Agronomy and Horticulture: Faculty Publications

The C4 grass pearl millet is one of the most drought tolerant cereals and is primarily grown in marginal areas where annual rainfall is low and intermittent. It was domesticated in sub-Saharan Africa, and several studies have found that it uses a combination of morphological and physiological traits to successfully resist drought. This review explores the short term and long-term responses of pearl millet that enables it to either tolerate, avoid, escape, or recover from drought stress. The response to short term drought reveals fine tuning of osmotic adjustment, stomatal conductance, and ROS scavenging ability, along with ABA and ethylene …

A Monographic Revision Of The Jewel Scarabs Genus Chrysina From Panama, Colombia, And Ecuador (Coleoptera: Scarabaeidae: Rutelinae: Rutelini), Manuel D. Barria

Zea E-Books Collection

The work is a taxonomic revision of 28 species of the genus Chrysina Kirby (Scarabaeidae: Rutelinae: Rutelini) found in Panama (25), Colombia (2), and Ecuador (3). Chrysina tricolor (Ohaus), Chrysina chalcothea (Bates), and Chrysina cupreomarginata (F. Bates) are new re­cords for Panama. A new country record from northern Colombia is confirmed for Chrys­ina mercedesae Barria. Chrysina gaitalica Curoe and Hawks and Chrysina galbina Hawks are discovered at new localities in Panama; females of both species are discovered and described. Chrysina aurora (Bates) known from other localities in the west of the country, is rediscov­ered in Veraguas province 147 years after …

In Vivo Gene Delivery Into Mouse Mammary Epithelial Cells Through Mammary Intraductal Injection, Wen Bu, Yi Li

Faculty, Staff and Students Publications

Mouse mammary glands comprise ductal trees, which are lined by epithelial cells and have one opening at the tip of each nipple. The epithelial cells play a major role in mammary gland function and are the origin of most mammary tumors. Introducing genes of interest into mouse mammary epithelial cells is a critical step in evaluating gene function in epithelial cells and generating mouse mammary tumor models. This goal can be accomplished through the intraductal injection of a viral vector carrying the genes of interest into the mouse mammary ductal tree. The injected virus subsequently infects mammary epithelial cells, bringing …

A Phase Ib/Ii Study Of Lenvatinib And Pembrolizumab In Advanced Endometrial Carcinoma (Study 111/Keynote-146): Long-Term Efficacy And Safety Update, Vicky Makker, Carol Aghajanian, Allen L Cohn, Margarita Romeo, Raquel Bratos, Marcia S Brose, Mark Messing, Lea Dutta, Corina E Dutcus, Jie Huang, Emmett V Schmidt, Robert Orlowski, Matthew H Taylor

Faculty, Staff and Student Publications

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.The open-label phase Ib/II Study 111/KEYNOTE-146 of daily lenvatinib 20 mg plus pembrolizumab 200 mg once every 3 weeks showed promising efficacy and tolerable safety in patients with previously treated advanced endometrial carcinoma (EC; primary data cutoff …

Associations Of Financial Toxicity With Symptoms And Unplanned Healthcare Utilization Among Cancer Patients Taking Oral Chemotherapy At Home: A Prospective Observational Study, Yongfeng Chen, Zhenxiang Chen, Haiyun Jin, Yanrong Chen, Jinbing Bai, Guifen Fu

Faculty, Staff and Student Publications

Background: Cancer patients with financial toxicity experience psychological distress and often miss medical appointments and quit treatments early, which could be a barrier to the effective management of oral chemotherapy drugs at home. This study explores whether financial toxicity predicts symptoms and unplanned healthcare utilization among cancer patients taking oral chemotherapy at home, which will contribute to the safe management of oral chemotherapy.

Methods: Data in this study was from a prospective observational study, which was conducted between October 2018 and December 2019. 151 patients completed the Comprehensive Score for Financial Toxicity at discharge and completed the MD Anderson Symptom …

Phase Ib Study Of Telisotuzumab Vedotin In Combination With Erlotinib In Patients With C-Met Protein-Expressing Non-Small-Cell Lung Cancer, D Ross Camidge, Fabrice Barlesi, Jonathan W Goldman, Daniel Morgensztern, Rebecca Heist, Everett Vokes, Alex Spira, Eric Angevin, Wu-Chou Su, David S Hong, John H Strickler, Monica Motwani, Martin Dunbar, Apurvasena Parikh, Elysa Noon, Vincent Blot, Jun Wu, Karen Kelly

Faculty, Staff and Student Publications

Purpose: Overexpression of c-Met protein and epidermal growth factor receptor (EGFR) mutations can co-occur in non-small-cell lung cancer (NSCLC), providing strong rationale for dual targeting. Telisotuzumab vedotin (Teliso-V), a first-in-class antibody-drug conjugate targeting c-Met, has shown a tolerable safety profile and antitumor activity as monotherapy. Herein, we report the results of a phase Ib study (ClinicalTrials.gov identifier: NCT02099058) evaluating Teliso-V plus erlotinib, an EGFR tyrosine kinase inhibitor (TKI), in patients with c-Met-positive (+) NSCLC.

Patients and methods: This study evaluated Teliso-V (2.7 mg/kg once every 21 days) plus erlotinib (150 mg once daily) in adult patients (age …

Health Benefits And Cost-Effectiveness Of Children's Oncology Group Breast Cancer Screening Guidelines For Chest-Irradiated Hodgkin Lymphoma Survivors, F Lennie Wong, Janie M Lee, Wendy M Leisenring, Joseph P Neglia, Rebecca M Howell, Susan A Smith, Kevin C Oeffinger, Chaya S Moskowitz, Tara O Henderson, Ann Mertens, Paul C Nathan, Yutaka Yasui, Wendy Landier, Gregory T Armstrong, Leslie L Robison, Smita Bhatia

Faculty, Staff and Student Publications

Purpose: To evaluate the outcomes and cost-effectiveness of the Children's Oncology Group Guideline recommendation for breast cancer (BC) screening using mammography (MAM) and breast magnetic resonance imaging (MRI) in female chest-irradiated childhood Hodgkin lymphoma (HL) survivors. Digital breast tomosynthesis (DBT), increasingly replacing MAM in practice, was also examined.

Methods: Life years (LYs), quality-adjusted LYs (QALYs), BC mortality, health care costs, and false-positive screen frequencies of undergoing annual MAM, DBT, MRI, MAM + MRI, and DBT + MRI from age 25 to 74 years were estimated by microsimulation. BC risks and non-BC mortality were estimated from female 5-year survivors of …

Fgl2-Targeting T Cells Exhibit Antitumor Effects On Glioblastoma And Recruit Tumor-Specific Brain-Resident Memory T Cells, Qingnan Zhao, Jiemiao Hu, Lingyuan Kong, Shan Jiang, Xiangjun Tian, Jing Wang, Rintaro Hashizume, Zhiliang Jia, Natalie Wall Fowlkes, Jun Yan, Xueqing Xia, Sofia F Yi, Long Hoang Dao, David Masopust, Amy B Heimberger, Shulin Li

Faculty, Staff and Student Publications

Although tissue-resident memory T (TRM) cells specific for previously encountered pathogens have been characterized, the induction and recruitment of brain TRM cells following immune therapy has not been observed in the context of glioblastoma. Here, we show that T cells expressing fibrinogen-like 2 (FGL2)–specific single-chain variable fragments (T-αFGL2) can induce tumor-specific CD8+ TRM cells that prevent glioblastoma recurrence. These CD8+ TRM cells display a highly expanded T cell receptor repertoire distinct from that found in peripheral tissue. When adoptively transferred to the brains of either immunocompetent or T cell-deficient naïve mice, these CD8+ TRM cells reject glioma cells. Mechanistically, T-αFGL2 …

Clinical Outcomes Of A Large-Scale, Partnership-Based Regional Food Prescription Program: Results Of A Quasi-Experimental Study, Nalini Ranjit, Jennifer N Aiyer, Jack D Toups, Esther Liew, Kenia Way, Henry Shelton Brown, John Wesley Mcwhorter, Shreela V Sharma

Faculty, Staff and Student Publications

BACKGROUND: Food prescription programs are gaining interest from funders, policy makers, and healthcare payers as a way to provide value-based care. A small body of research suggests that such programs effectively impact health outcomes; however, the quality of existing studies is variable, and most studies use small samples. This study attempts to address these gaps by utilizing a quasi-experimental design with non-equivalent controls, to evaluate clinical outcomes among participants enrolled in a food prescription program implemented at scale.

METHODS: We completed a secondary analysis of participant enrollment and utilization data collected between May 2018 and March 2021, by the Houston …

Deep Learning For Detecting And Elucidating Human T-Cell Leukemia Virus Type 1 Integration In The Human Genome, Haodong Xu, Johnathan Jia, Hyun-Hwan Jeong, Zhongming Zhao

Faculty, Staff and Student Publications

Human T-cell leukemia virus type 1 (HTLV-1), a retrovirus, is the causative agent for adult T cell leukemia/lymphoma and many other human diseases. Accurate and high throughput detection of HTLV-1 virus integration sites (VISs) across the host genomes plays a crucial role in the prevention and treatment of HTLV-1-associated diseases. Here, we developed DeepHTLV, the first deep learning framework for VIS prediction de novo from genome sequence, motif discovery, and cis-regulatory factor identification. We demonstrated the high accuracy of DeepHTLV with more efficient and interpretive feature representations. Decoding the informative features captured by DeepHTLV resulted in eight representative clusters …

Greenbug Feeding-Induced Resistance To Sugarcane Aphids In Sorghum, Heena Puri, Edith Ikuze, Jessica Ayala, Isabella Rodriguez, Rupesh R. Kariyat, Joe Louis, Sajjan Grover

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Plants are attacked by multiple insect pest species and insect herbivory can alter plant defense mechanisms. The plant defense responses to a specific herbivore may also contribute to the herbivore growth/survival on plants. Feeding by one insect species can modulate the plant defenses, which can either facilitate or hamper the colonization of subsequent incoming insects. However, little is known about the effect of sequential herbivory on sorghum plants. In this study, we demonstrate that a specialist aphid, sugarcane aphid (SCA; Melanaphis sacchari) grows faster on sorghum than a generalist aphid species, greenbug (GB; Schizaphis graminum). We also determined …

Agriculture Water Use And Economic Value In The Great Salt Lake Basin, Cody Zesiger, Burdette Barker, Sarah Null, Earl Creech, Matt Yost, Ryan Larsen, Joshua Dallin

All Current Publications

This fact sheet briefly describes human impacts on GSL water volume, human population growth, surface water withdrawals, and agricultural water use from 1985 and 2015 in the GSL Basin. Finally, agriculture’s economic impact and food production in the GSL Basin are summarized.

The Metabolic And Physiological Demands Of A Simulated Fire Ground Test Versus A Live-Fire Training Evolution In Professional Firefighters, Drew Edward Gonzalez, Hunter Waldman, Matthew J. Mcallister

International Journal of Exercise Science

International Journal of Exercise Science 16(7): 230-241, 2023. Objective: This study examined the similarities in metabolic and physiological demands of a fire ground test (FGT) and a live fire training evolution. Methods: Twenty-seven firefighters completed either a FGT (n = 13) or a live fire training evolution (n = 14). Salivary samples were collected pre, immediately post, and 30-minutes post FGT and live fire training evolution, and analyzed for cortisol, uric acid, and interleukin-1β (IL-1β). Heart rate (HR) was measured pre- and post-task. Results: Both tasks resulted in significant elevations in cortisol, IL-1β, and HR. Conclusions: Both the …

Ischemic Preconditioning Improves The Bench-Press Maximal Strength In Resistance-Trained Men, Anderson Luiz Rodrigues, Bernardo N. Ide Dr., Jeffer Eidi Sasaki, Donizete Cicero X. De Oliveira Oliveira, Claudio De Oliveira Assumpção, Moacir Marocolo, Gustavo Mota

International Journal of Exercise Science

International Journal of Exercise Science 16(4): 217-229, 2023. We investigated whether acute ischemic preconditioning (IPC) would affect upper limb maximal strength performance in resistance-trained men. Using a counterbalanced randomized crossover design, fifteen men (29.9 ± 5.9 yrs.; 86.3 ± 9.6 kg; 8.0 ± 5.0 yrs. resistance training experience) performed one-repetition maximum (1-RM) bench press tests on three different occasions: control, 10 min post-IPC or 10 min post-placebo (SHAM). One-way analysis of variance showed that the post-IPC condition increased (P < 0.0001) 1-RM loads compared to both control and post-SHAM (control 113.3 ± 15.9 kg vs. SHAM 113.9 ± 15.8 kg vs. IPC 115.7 ± 15.6 kg), while control and SHAM did not differ (P > 0.05). Individual results showed that 13 participants (~87%) improved their performance post-IPC compared to control, and 11 participants (~73%) …

A New Species Of Scorpio From Jordan (Scorpiones: Scorpionidae), Mohammad Al-Saraireh, Ersen A. Yağmur, Bassam Abu Afifeh, Zuhair Amr

Euscorpius

A new species Scorpio granulomanus sp. n. is described and illustrated from Dibbeen Forest, Jerash Governorate, Jordan. The new species is compared with the previously recorded species of the genus Scorpio L., 1758 in the Middle East; it can be distinguished from all other congeners by its very large, pointed granules on the dorsoexternal surface of the chela manus, and an untypically elongated chela manus.

Household Food Security In The Mountain West, 2021, Zachary Walusek, Corryn Richardson, Issac Hernandez-Alcaraz, Annie Vong, Caitlin J. Saladino, William E. Brown Jr.

Health

This fact sheet examines data on household food security published by the United States Department of Agriculture. We examine the prevalence of household food insecurity and very low food security in Mountain West states (Arizona, Colorado, Nevada, New Mexico, and Utah) and the United States national average for comparative analysis.

Comfrey In The Garden, Emmalee Rolfe, Dan Drost

All Archived Publications

Comfrey (Symphytum officinale) is a very hardy perennial herb adaptable to most conditions. Comfrey grows best in partial to full sun in moist, fertile soil. Comfrey is propagated by root cuttings or crown divisions. Comfrey can be planted throughout the growing season but establishes best when planted in the spring. Maintain moderate soil moisture, especially when plants are young. Once established, comfrey outcompetes weeds and does not have any reported insect or disease issues in Utah. Some leaves and roots are harvested after the first year of growth. It should be noted that consuming high doses or excessive …

Great Salt Lake Policy Assessment: A Synthesized Resource Document For The 2023 General Legislative Session, William Anderegg, Craig Buttars, Joel Ferry, Natalie Gochnour, Kim Shelley, Brian Steed, David Tarboton, Leila Ahmadi, Eric Albers, Blake Bingham, Paul Brooks, Joanna Endter-Wada, Candice Hasenyager, John Lin, Anna Mcentire, Bethany Neilson, Sarah Null, Kevin Perry, Ben Stireman, Courenay Strong, Kyla Welch, Matt Yost

Watershed Sciences Faculty Publications

Declining water levels threaten economic activity, public health, and ecosystems of Great Salt Lake and surrounding communities. This policy assessment provides a summary of data, insights, and policy options that will inform strategies to improve water management and increase deliveries to the lake.

Responses Of Extreme Discharge To Changes In Surface-Air And Dewpoint Temperatures In Utah: Seasonality And Mechanisms, Timothy E. Wright, Jacob Stuivenvolt-Allen, Grace Affram, Nahid A. Hasan, Cody Ratterman, Wei Zhang

Plants, Soils, and Climate Faculty Publications

The changes in stream discharge extremes due to temperature and seasonality are key metrics in assessing the effects of climate change on the hydrological cycle. While scaling is commonly applied to temperature and precipitation due to the physical connections between temperature and moisture (i.e., Clausius–Clapeyron), the scaling rate of stream discharge extremes to air and dewpoint temperatures has not been evaluated. To address this challenge, we assess the scaling rates between stream discharge and air temperature and between stream discharge and dewpoint temperature in Utah using a well-designed statistical framework. While there are deviations from the Clausius–Clapeyron (CC) relationship in …

Digital Atlas Of The Vascular Plants Of Utah, R. Douglas Ramsey, Leila M. Shultz, Wanda Lindquist, Chris Garrard, Mindy Wheeler

Browse all Datasets

Locations of 74,755 vascular plant vouchers representing 2,425 species were digitized into a spatial database from the Atlas of the Vascular Plants of Utah (Albee et al. 1988). Source maps consisted of 1:6,000,000-scale shaded relief maps of Utah with points representing collection locations by species. Location points, representing 1 or more specimens, were transposed onto these maps from the approximately 400,000 herbarium records of 3 major universities and federal land management agencies.