Life Sciences Commons^™

Identifying Direct Foxo Targets Through Chromatin Immunoprecipitation Assays With Sequencing, Alma Lopez

Theses and Dissertations

Glioblastoma Multiforme (GBM) and basal-like breast cancer (BBC) are aggressive cancers associated with poor prognoses. Basal-like breast cancer (BBC) and glioblastoma multiforme (GBM) are poor prognosis cancers that lack effective targeted therapies. A deregulation of FOXOs has been linked to cancer, as they regulate the expression of genes involved in multiple cellular processes. Canonically, the FOXO family of proteins is generally considered tumor suppressors, but evidence suggests that they may be involved in cancer metabolism as well as angiogenesis. Research in our lab has found that these factors play a role in glycolysis and the developmental WNT pathway. Here we …

Opensim-Based Musculoskeletal Modeling: Foundation For Interactive Obstetric Simulator, Bahador Dodge

Electrical & Computer Engineering Theses & Dissertations

The use of mathematical and computational models to understand complex biological systems, such as the human birth process, is a rapidly growing field in medicine. These models can be used to optimize and personalize medical treatments for individual patients, enhance training, and aid in educational efforts. While recent advancements in healthcare, particularly in obstetrics, have improved care for mothers and babies, studies and government reports indicate a rising rate of maternal mortality in the United States.

Despite this rising trend, there is a lack of detailed studies concerning the use of modeling and simulation to develop an interactive obstetrics simulator …

Nanosecond Pulsed Electric Field Modulates Electron Transport And Mitochondrial Structure And Function, Lucas Nelson Potter

Biomedical Engineering Theses & Dissertations

Pulsed power treatment has been used to induce regulated cell death (RCD) in cells or ablate tumors in animals. A subset of pulsed power as electroporation with high voltage and pulse duration of milliseconds is used for biomedical treatment to induce pores in the plasma membrane of cells. Nanosecond Pulsed Electric Fields (nsPEFs)– an extension of electroporation, uses waveforms with pulse durations on the order of 10-900 nanoseconds. nsPEF treatment has demonstrated intracellular effects for potential biomedical applications. In this work, nsPEF treatment is used to demonstrate changes that affect viability, plasma membrane permeability ROS (Reactive Oxygen Species) in the …

Salivary Microrna As A Concussion Biomarker And The Implications For Athletic Trainers' Practices, Thomas Richard Campbell

Rehabilitation Sciences Theses & Dissertations

Many concussions are sustained globally each year; however, research suggests that a large number may go undiagnosed due to a reliance on subjective information from patients and limitations of current objective measures. Recently, efforts have been focused on identifying clinical biomarkers of concussions, including salivary microRNA (miRNA), to improve healthcare professionals’ concussion management practices. Even if salivary miRNA were shown to be a valid and reliable measure for managing concussions, healthcare professionals, such as athletic trainers (ATs), must be familiar with the tool and have positive attitudes toward the implementation into clinical practice. Therefore, the purpose of this dissertation was …

A Characterization Of The Quadruple Mutant Of The Fgf1-Fgf2 Heterodimer, Kenlee Claborn

Chemistry & Biochemistry Undergraduate Honors Theses

Human Fibroblast Growth Factor (FGF) was first identified as a protein whose function was to aid in cell proliferation, but now, FGF has been determined to consist of over 23 different proteins in 7 different subfamilies with three different types of cell-signaling purposes.¹ In the first subfamily are the two most notable and studied proteins, Fibroblast Growth Factor 1 (FGF1) and Fibroblast Growth Factor 2 (FGF2). Respectively, they are known for their unique capabilities of cell proliferation/mitogenesis and angiogenesis.² To induce the cell-signaling pathway that leads to the function of these proteins, FGF1 and FGF2 binds to their …

Cardiac Ablation And Stimulation With Nanosecond Pulsed Electric Fields (Nspefs), Federica Serra

Biomedical Engineering Theses & Dissertations

Surgical ablation of cardiac tissue is the definitive treatment for the most common arrhythmia, atrial fibrillation. In current medical practice, myocardial tissue is often ablated by the application of radiofrequency (RF) currents which are delivered through an electrode to create lesions that block the electrical pathways that sustain reentrant arrhythmias and restore the normal heart rhythm. An alternative to RF is cryoablation, during which the endocardial or epicardial tissue is brought in contact with a cryoprobe. Both RF ablation and cryoablation have significant limitations. In RF ablation, tissue is heated in order to ablate it, but it is an open …

Letters From The Professors

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Ptsd: The Way In & The Way Out, Carolyn Herbosa

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Psychopaths: Who Are They, Really?, Stephanie Kaufman

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Your Brain On Plastics, Bennett Andrassy

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Music Makes You Lose Control, Jac Cousineau

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

More Synapses, More Problems: The Underdiagnosis Of Depression In Patients With Temporal Lobe Epilepsy, Daisy Delgado

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Life Stressors And Immune Aging: Protective Effects Of Cognitive Reappraisal, Rebecca G. Reed, Steven R. Presnell, Ahmad Al-Attar, Charles T. Lutz, Suzanne C. Segerstrom

Markey Cancer Center Faculty Publications

Stressful life events may accelerate aspects of immune aging, but habitual use of an adaptive emotion regulation strategy, cognitive reappraisal, may attenuate these effects. This study examined whether cognitive reappraisal moderates the associations between life stressor frequency and stressor desirability on aspects of immune aging, including late-differentiated CD8+ T and natural killer (NK) cells and inflammatory markers (IL-6, TNF-α, and CRP), both between and within people in a longitudinal sample of 149 older adults (mean age = 77.8, range: 64–92 years). Participants reported stressful life events, use of cognitive reappraisal, and provided blood semiannually for up to 5 years to …

Nigella Sative As An Antibiotic Alternative To Promote Growth And Enhance Health Of Broilers Challenged With Eimeria Maxima And Clostridium Perfringens, Vishal Manjunatha, Julian E. Nixon, Greg F. Mathis, Brett S. Lumpkins, Zeynep B. Guzel-Seydim, Atif C. Seydim, Annel K. Greene, Xiuping Jiang

Publications

The poultry industry has significant coccidiosis and necrotic enteritis (NE) challenges, leading to high mortality and unacceptable growth without antibiotic treatment. This research explored supplementing Nigella sativa (black cumin) seed oil in poultry feed to mitigate coccidiosis and prevent or lessen NE in broilers. In vivo studies consisted of 384 and 320 Cobb 500 male broiler chicks distributed in a randomized complete block experimental design for trials 1 and 2, respectively. The first trial compared 3 concentrations (1, 2, and 5 mL/kg) of black cumin seed oil (BCSO), and trial 2 compared 2 concentrations (2 and 5 mL/kg) BCSO, with …

The Reinforcement Enhancing Effects Of Delta-9-Tetrahyrdrocannabinol (Thc) In Male And Female Rats, Kynah Walston

Electronic Theses and Dissertations

Cannabis is widely consumed by humans for pharmacological effects that are mediated by THC, though there is little evidence that THC is a primary reinforcer in non-human animal models. We hypothesized that THC may have potent reinforcement enhancing effects, comparable to other drugs (e.g., nicotine and caffeine) which are also widely consumed by humans, but difficult to establish as primary reinforcers in non-humans. In three experiments with male and female rats saccharin (SACC) or a visual stimulus (VS) served as reinforcers for operant behavior. We explored several pharmacological parameters of THC on responding for SACC or VS, including THC dose, …

Urbanization Affects Web Abundance And Aggregation Of A Funnel‑Weaving Spider, Agelenopsis Pennsylvanica (Agelenidae), Brandi J. Pessman, Madison Hays, Earl Agpawa, Eileen Hebets

Eileen Hebets Publications

Animals distribute themselves within habitats based on a variety of environmental conditions, including those impacted by urbanization. Suspected global declines in urban arthropod biodiversity have required that we examine how urban conditions affect the distribution of this ecologically important group. Throughout North America, funnel-weaving spiders (Agelenidae) are prevalent across urban habitats and actively choose sites to build webs. We compared Agelenopsis pennsylvanica abundance and distribution between two distinct urban habitats: an urban center (university campus) and an urban forest (city park). These urban habitats differed significantly in features like plant diversity and proximity to roads and highways. We searched along …

Assessing Athletes’ Risk For Developing The Female Athlete Triad At Two Mississippi Universities, Laura G. Warren

Honors Theses

Despite the health benefits associated with regular exercise, some female athletes experience menstrual dysfunction and low bone mineral density associated with low energy availability as a result of a high volume of exercise and inadequate caloric intake; these three components characterize the female athlete triad (FAT). Prior research explored the severity of the FAT, pre-season screenings, and nutrition intervention methods; however, current research regarding the relationship between the risk for developing the FAT and access to nutrition resources is lacking. The purpose of this study was to assess the risk of female athletes at two Mississippi universities for developing the …

Effect Of Temperature On The Microbiome Of A Laboratory-Reared Colony Of Haemaphysalis Longicornis Ticks, Brianna L. Mitchell

Honors Theses

Haemaphysalis longicornis ticks are invasive to the United States with potential to transmit several tick-borne pathogens that are native to the United States. Based on existing locations of H. longicornis in its native regions in Asia, as well as its invasive populations that are established in the United States, several geographic range prediction models have been produced to help understand future range expansion and distribution of this invasive tick in North America. Unfortunately, these models do not all agree and there is uncertainty associated with the potential geographic range expansion of H. longicornis ticks in North America. Climate can affect …

Understanding The Spatiotemporal Abundance Of Soybean Gall Midge In Soil Of Infested Soybean Fields, Mikaelison Da Silva Lima

Department of Entomology: Dissertations, Theses, and Student Research

Soybean gall midge, Resseliella maxima Gagné (Diptera: Cecidomyiidae), was identified in 2019 after injury was reported in soybean in four midwestern U.S. states. Heavy infestations have the potential to result in the total loss of yield in the first 30 meters near the field edge. Larvae feed under the plant epidermis after hatching from eggs laid in natural openings near the base of the plant stem. This feeding causes dark discolorations and necrosis of the affected areas. After feeding the larvae leave the plant to form a cocoon and pupate in the soil. Adults can emerge in the same season …

The Mind Behind The Buy: Exploring The World Of Neuromarketing, Gabriela Cruz Echeverria

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

(Maybe Not) All Of The Lights, Babiker Higazi

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Scientific Kenyon: Neuroscience Edition (Full Issue)

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Did: Is It Trauma Or Just Fantasy?, Sebastian Geeze

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Man's Best Friend Finally Talks Back: Bunny The "Talking" Dog, Maeve Griffin

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

A Brief History Of Psychedelia: From Ancient Rituals To Modern Medicine, Vikas Gudhe

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Memory Comes In Waves: How Sharp-Wave Ripple Dynamics Are Disrupted By Sleep Deprivation, Maximos Mccune

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Neurodegeneration: You Have More Influence Than You Might Think, Ben Shropshire

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Building A Better Athlete: How Great Coaches Game The Nervous System For Optimal Performance, Mark Lang

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Binaural Beats: Good Or Goop?, Sari Wagner

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Dispelling Depression Dogma: Why Depression Is More Than A Chemical Imbalance, Jorge Roman

Scientific Kenyon: The Neuroscience Edition

No abstract provided.