Life Sciences Commons^™

Acute Effects Of Different Set Configurations On Neuromuscular, Metabolic, And Perceptual Responses In Young Women, Francisco Dalton-Alves, Lígia Martins, Witalo Kassiano, Mário Simim, Alexandre I. A. Medeiros, Cláudio De O. Assumpção

International Journal of Exercise Science

International Journal of Exercise Science 16(4): 974-986, 2023. We compared neuromuscular, metabolic, and perceptual responses between different resistance training configurations in young women. In a counterbalanced randomized order, 13 young women performed the following protocols in separate sessions (sets x repetitions): traditional (TRAD): 5x10, 90-s of rest interval between sets; more frequent and shorter total rest (FSR): 10x5, 30-s of rest interval between sets. The sessions were composed of leg press exercise with the same intensity. Force (maximum voluntary isometric contraction [MVIC]) and metabolic (lactate concentration) responses were measured pre- and post-resistance training sessions. The rating of perceived exertion (RPE) …

Does Beta-Alanine Supplementation Potentiate Muscle Performance Following 6 Weeks Of Blood Flow Restriction Or Traditional Resistance Training?, Kassiana De Araujo Pessoa, Jason Michael Cholewa, Rayssa Sousa-Silva, Xia Zhi, Alessandro M. Zagatto, Antonio Herbert Lancha-Jr, Jakob D. Lauver, Fabricio Eduardo Rossi, Nelo Zanchi

International Journal of Exercise Science

International Journal of Exercise Science 16(2): 999-1011, 2023. We aimed to compare the effects of beta-alanine on Traditional Resistance Training (TRAD) or Blood Flow Restriction Training (BFR). Methods: 19 subjects were randomly allocated to a Placebo (n = 10) or beta-alanine (n = 9) group. Subjects from both groups were trained unilaterally (unilateral arm curl) for six weeks, and each arm was trained using a different paradigm (BFR or TRAD). One repetition maximum (1RM) test measurements were performed before and after the strength training program. Work output was accessed as the total weight lifted (repetitions × weight lifted …

A New, Simple And Practical Approach To Increase The Effects Of Aerobic Exercise On Serum Levels Of Neurotrophic Factors In Adult Males, Mahdi Bahramnejad, Vahid Valipour Dehnou, Rasoul Eslami

International Journal of Exercise Science

International Journal of Exercise Science 16(2): 932-941, 2023. Environmental enrichment (EE) is defined as a combination of complex inanimate and social stimulation. Physical activity and EE may augment the beneficial effects of each other. This study aimed to assess the effects of running in an enriched environment on neurotrophic factors in adult males. Twelve volunteer adult males (age 26.75 ± 5.34 yrs, body mass 70.72 ± 8.61 kg, height 172.50 ± 5.68 cm, VO_2max 56.8 ± 2.93) completed two sessions, each consisted of one hour of running at an intensity of 12-13 on the Borg Scale. One session was …

Performance Kinetics During Repeated Sprints Is Influenced By Knowledge Of Task Endpoint And Associated Peripheral Fatigue, François Billaut, Marie R. Demers, Andrew Hibbert

International Journal of Exercise Science

International Journal of Exercise Science 16(1): 987-998, 2023. The regulation of exercise intensity allows an athlete to perform an exercise in the fastest possible time while avoiding debilitating neuromuscular fatigue development. This phenomenon is less studied during intermittent activities. To investigate anticipatory and real-time regulation of motor output and neuromuscular fatigue during repeated-sprint exercise, twelve males randomly performed one (S1), two (S2), four (S4) and six (S6) sets of five 5-s cycling sprints. Mechanical work and electromyographic activity were assessed during sprints. Potentiated quadriceps twitch force (ΔQ_tw,pot) and central activation ratio (Q_CAR) were quantified from response …

The Effects Of Postural Education Or Corrective Exercise On The Craniovertebral Angle In Young Adults With Forward Head Posture: A Randomized Controlled Trial, David A. Titcomb, Bridget F. Melton, Theresa Miyashita, Helen W. Bland

International Journal of Exercise Science

International Journal of Exercise Science 16(1): 954-973, 2023. The purpose of this study was to compare the effects of three different intervention strategies, postural education (PE) and two corrective exercise programs (CEPs), on the craniovertebral angle (CVA) in young adults with forward head posture (FHP). A prospective four-arm parallel randomized controlled trial with repeated measures was performed. Seventy-nine healthy young adults (55 women, 24 men; mean age: 20.08 ± 2.19 years) with FHP were randomized into four groups: PE group, self-myofascial release + stretching group (SMRS), self-myofascial release + stretching + strengthening group (SMRSS), and a control group (CG). Participant …

Increasing Trunk Mass Evokes Lower Extremity Biomechanical Plasticity During Stair Descent, Alexis Nelson, Hailey Fong, Alex Carnall, Melissa J. Puppa, Derek Beeler, Cris Stickley, William M. Mihalko, Douglas W. Powell

International Journal of Exercise Science

International Journal of Exercise Science 16(1): 942-953, 2023. The purpose of this study was to investigate the influence of simulated changes in body mass on lower extremity joint work and relative joint contributions during stair descent. Ten healthy recreationally active college-age participants performed five stair descent trials in each of five loading conditions: no added load and with an additional 5%, 10%, 15% and 20% of their body weight. Three-dimensional ankle, knee and hip joint powers were calculated using a six degree-of-freedom model in Visual3D (C-Motion Inc., Germantown, MD, USA). Sagittal plane joint work was calculated as the joint power …

Mosca Linterna Moteada, Lori R. Spears, Ann Mull, Celina Wille, Marion Murray

All Current Publications

La mosca linterna moteada es una nueva saltahojas invasiva en Norteamérica. Es originaria del norte de China y se ha extendido a otras partes de Asia, incluidos Vietnam, Japón y Corea del Sur, donde está causando daños significativos a la vid.

Escarabajo Japonés, Lori Spears, Diane Alston, Marion Murray, Joey Caputo, Kristopher Watson, Celina Wille

All Current Publications

El escarabajo Japonés es una plaga invasora que puede ser muy destructiva para plantas ornamentales, árboles, arbustos, césped, y algunas frutas y hortalizas. El EJ probablemente se introdujo desde Japón al este de los EE. UU. en 1916 durante envíos de plantas ornamentales. Ahora está establecido en la mayoría de los estados del este y algunos del medio oeste.

Auricularia Auricula Polysaccharides Attenuate Obesity In Mice Through Gut Commensal Papillibacter Cinnamivorans, Xin Zong, Hao Zhang, Luoyi Zhu, Edward C. Deehan, Jie Fu, Yizhen Wang, Mingliang Jin

Department of Nutrition and Health Sciences: Faculty Publications

Introduction: Auricularia auricula is a well-known traditional edible and medical fungus with high nutritional and pharmacological values, as well as metabolic and immunoregulatory properties. Nondigestible fermentable polysaccharides are identified as primary bioactive constituents of Auricularia auricula extracts. However, the exact mechanisms underlying the effects of Auricularia auricula polysaccharides (AAP) on obesity and related metabolic endpoints, including the role of the gut microbiota, remain insufficiently understood.

Methods: The effects of AAP on obesity were assessed within high-fat diet (HFD)-based mice through obesity trait analysis and metabolomic profiling. To determine the mechanistic role of the gut microbiota in observed anti-obesogenic …

Picudos En El Césped, Desireè Wickwar, Ricardo Ramírez, Marion Murray, Celina Wille

All Current Publications

Los picudos son gorgojos, un tipo de escarabajo, del género Sphenophorus. Al menos 10 especies de picudos se reconocen como plagas del césped, y se pueden encontrar tanto en céspedes estivales como invernales en todo Estados Unidos.

Insects Are Attracted To White Wind Turbine Bases: Evidence From Turbine Mimics, Madison S. Crawford, Delina E. Dority, Michael E. Dillon, Lusha M. Tronstad

Western North American Naturalist

Wind power is one of the fastest growing forms of renewable energy, but the interactions between wind turbines and insects are largely unknown beyond the observation that the accumulation of dead insects on turbine blades drastically reduces the power produced. Insects may be attracted to wind energy facilities because of topography, the heat that turbines produce, the lighting, or the visual cue of the turbine itself. Turbines can present a striking visual contrast relative to the surrounding landscape, particularly when they are painted bright white and reflect ultraviolet wavelengths. To test the hypothesis that wind turbine color attracts insects, we …

Two Structurally Defined Aβ Polymorphs Promote Different Pathological Changes In Susceptible Mice, Ruben Gomez-Gutierrez, Ujjayini Ghosh, Wai-Ming Yau, Nazaret Gamez, Katherine Do, Carlos Kramm, Hamid Shirani, Laura Vegas-Gomez, Jonathan Schulz, Ines Moreno-Gonzalez, Antonia Gutierrez, K Peter R Nilsson, Robert Tycko, Claudio Soto, Rodrigo Morales

Faculty, Staff and Student Publications

Misfolded Aβ is involved in the progression of Alzheimer's disease (AD). However, the role of its polymorphic variants or conformational strains in AD pathogenesis is not fully understood. Here, we study the seeding properties of two structurally defined synthetic misfolded Aβ strains (termed 2F and 3F) using in vitro and in vivo assays. We show that 2F and 3F strains differ in their biochemical properties, including resistance to proteolysis, binding to strain-specific dyes, and in vitro seeding. Injection of these strains into a transgenic mouse model produces different pathological features, namely different rates of aggregation, formation of different plaque types, …

Biophysically-Informed Models Of Heterogeneity In Transcription Factor Activity, Kaiser Loell

Arts & Sciences Graduate Student Theses and Dissertations

The activity of a transcription factor (TF) can be remarkably heterogeneous, both within andbetween cells. Between cells, molecular fluctuations drive stochastic differences in the activitiesof TFs. I will describe a project in which we have quantified how the different components of aTF (its activation domain, affinity for DNA, concentration, and cooperative interactions) influencestochastic fluctuations in TF activity. In addition to stochastic fluctuations between cells, withincells TFs can switch between activating and repressing activities depending on the cis-regulatorycontent of their target genes. I will describe a second project in which we have modelled howthe balance between homo- and heterotypic interactions determines …

Moving The Pendulum For Glioblastoma Treatment: One Injection At A Time, Xizi Wu, Christopher Alvarez-Breckenridge

Faculty, Staff and Student Publications

Despite advances, glioblastoma is characterized by exceptionally high rates of recurrence and resistance to therapy. This commentary remarks on the recently published article by Maruyama et al, which reports the PMDA review of G47Δ injection for malignant glioma, in which the efficacy and safety results of G47Δ were evaluated and approval conditions clarified.

Genotype Error Due To Low-Coverage Sequencing Induces Uncertainty In Polygenic Scoring, Ella Petter, Yi Ding, Kangcheng Hou, Arjun Bhattacharya, Alexander Gusev, Noah Zaitlen, Bogdan Pasaniuc

Faculty, Staff and Student Publications

Polygenic scores (PGSs) have emerged as a standard approach to predict phenotypes from genotype data in a wide array of applications from socio-genomics to personalized medicine. Traditional PGSs assume genotype data to be error-free, ignoring possible errors and uncertainties introduced from genotyping, sequencing, and/or imputation. In this work, we investigate the effects of genotyping error due to low coverage sequencing on PGS estimation. We leverage SNP array and low-coverage whole-genome sequencing data (lcWGS, median coverage 0.04×) of 802 individuals from the Dana-Farber PROFILE cohort to show that PGS error correlates with sequencing depth (p = 1.2 × 10

Beyond The Exome: What’S Next In Diagnostic Testing For Mendelian Conditions, Monica H Wojcik, Chloe M Reuter, Shruti Marwaha, Medhat Mahmoud, Michael H Duyzend, Hayk Barseghyan, Bo Yuan, Philip M Boone, Emily E Groopman, Emmanuèle C Délot, Deepti Jain, Alba Sanchis-Juan, Genomics Research To Elucidate The Genetics Of Rare Diseases (Gregor) Consortium, Lea M Starita, Michael Talkowski, Stephen B Montgomery, Michael J Bamshad, Jessica X Chong, Matthew T Wheeler, Seth I Berger, Anne O'Donnell-Luria, Fritz J Sedlazeck, Danny E Miller

Faculty, Staff and Student Publications

Despite advances in clinical genetic testing, including the introduction of exome sequencing (ES), more than 50% of individuals with a suspected Mendelian condition lack a precise molecular diagnosis. Clinical evaluation is increasingly undertaken by specialists outside of clinical genetics, often occurring in a tiered fashion and typically ending after ES. The current diagnostic rate reflects multiple factors, including technical limitations, incomplete understanding of variant pathogenicity, missing genotype-phenotype associations, complex gene-environment interactions, and reporting differences between clinical labs. Maintaining a clear understanding of the rapidly evolving landscape of diagnostic tests beyond ES, and their limitations, presents a challenge for non-genetics professionals. …

Safety And Efficacy Of Immune Checkpoint Inhibitors In Patients With Cancer And Viral Hepatitis: The Md Anderson Cancer Center Experience, Mirella Nardo, Bulent Yilmaz, Blessie Elizabeth Nelson, Harrys A Torres, Lan Sun Wang, Bruno Palma Granwehr, Juhee Song, Hanna R F Dalla Pria, Van A Trinh, Isabella C Glitza Oliva, Sapna P Patel, Nizar M Tannir, Ahmed Omar Kaseb, Mehmet Altan, Sunyoung S Lee, Ethan Miller, Hao Zhang, Bettzy A Stephen, Aung Naing

Faculty, Staff and Student Publications

Background: Despite the clinical benefit of immune checkpoint inhibitors (ICIs), patients with a viral hepatitis have been excluded from clinical trials because of safety concerns. The purpose of this study was to determine the incidence rate of adverse events (AEs) in patients with viral hepatitis who received ICIs for cancer treatment.

Materials and methods: We conducted a retrospective study in patients with cancer and concurrent hepatitis B or C, who had undergone treatment with ICI at MD Anderson Cancer Center from January 1, 2010 to December 31, 2019.

Results: Of the 1076 patients screened, we identified 33 with concurrent hepatitis. …

Proteogenomic Analysis Of Chemo-Refractory High-Grade Serous Ovarian Cancer, Shrabanti Chowdhury, Jacob J Kennedy, Richard G Ivey, Oscar D Murillo, Noshad Hosseini, Xiaoyu Song, Francesca Petralia, Anna Calinawan, Sara R Savage, Anna B Berry, Boris Reva, Umut Ozbek, Azra Krek, Weiping Ma, Felipe Da Veiga Leprevost, Jiayi Ji, Seungyeul Yoo, Chenwei Lin, Uliana J Voytovich, Yajue Huang, Sun-Hee Lee, Lindsay Bergan, Travis D Lorentzen, Mehdi Mesri, Henry Rodriguez, Andrew N Hoofnagle, Zachary T Herbert, Alexey I Nesvizhskii, Bing Zhang, Jeffrey R Whiteaker, David Fenyo, Wilson Mckerrow, Joshua Wang, Stephan C Schürer, Vasileios Stathias, X Steven Chen, Mary Helen Barcellos-Hoff, Timothy K Starr, Boris J Winterhoff, Andrew C Nelson, Samuel C Mok, Scott H Kaufmann, Charles Drescher, Marcin Cieslik, Pei Wang, Michael J Birrer, Amanda G Paulovich

Faculty, Staff and Student Publications

To improve the understanding of chemo-refractory high-grade serous ovarian cancers (HGSOCs), we characterized the proteogenomic landscape of 242 (refractory and sensitive) HGSOCs, representing one discovery and two validation cohorts across two biospecimen types (formalin-fixed paraffin-embedded and frozen). We identified a 64-protein signature that predicts with high specificity a subset of HGSOCs refractory to initial platinum-based therapy and is validated in two independent patient cohorts. We detected significant association between lack of Ch17 loss of heterozygosity (LOH) and chemo-refractoriness. Based on pathway protein expression, we identified 5 clusters of HGSOC, which validated across two independent patient cohorts and patient-derived xenograft (PDX) …

Combined Crispri And Proteomics Screening Reveal A Cohesin-Ctcf-Bound Allele Contributing To Increased Expression Of Ruvbl1 And Prostate Cancer Progression, Yijun Tian, Dandan Dong, Zixian Wang, Lang Wu, Jong Y Park, Gong-Hong Wei, Liang Wang

Faculty, Staff and Student Publications

Genome-wide association studies along with expression quantitative trait locus (eQTL) mapping have identified hundreds of single-nucleotide polymorphisms (SNPs) and their target genes in prostate cancer (PCa), yet functional characterization of these risk loci remains challenging. To screen for potential regulatory SNPs, we designed a CRISPRi library containing 9,133 guide RNAs (gRNAs) to cover 2,166 candidate SNP loci implicated in PCa and identified 117 SNPs that could regulate 90 genes for PCa cell growth advantage. Among these, rs60464856 was covered by multiple gRNAs significantly depleted in screening (FDR < 0.05). Pooled SNP association analysis in the PRACTICAL and FinnGen cohorts showed significantly higher PCa risk for the rs60464856 G allele (p value = 1.2 × 10

Novel Murine Glioblastoma Models That Reflect The Immunotherapy Resistance Profile Of A Human Disease, Chao-Hsien Chen, Renee L Chin, Genevieve P Hartley, Spencer T Lea, Brian J Engel, Cheng-En Hsieh, Rishika Prasad, Jason Roszik, Takashi Shingu, Gregory A Lizee, Amy B Heimberger, Steven W Millward, Jian Hu, David S Hong, Michael A Curran

Faculty, Staff and Student Publications

BACKGROUND: The lack of murine glioblastoma models that mimic the immunobiology of human disease has impeded basic and translational immunology research. We, therefore, developed murine glioblastoma stem cell lines derived from Nestin-CreERT2QkL/L; Trp53L/L; PtenL/L (QPP) mice driven by clinically relevant genetic mutations common in human glioblastoma. This study aims to determine the immune sensitivities of these QPP lines in immunocompetent hosts and their underlying mechanisms.

METHODS: The differential responsiveness of QPP lines was assessed in the brain and flank in untreated, anti-PD-1, or anti-CTLA-4 treated mice. The impact of genomic landscape on the responsiveness of each tumor was measured through …

Facs-Based Genome-Wide Crispr Screens Define Key Regulators Of Dna Damage Signaling Pathways, Min Huang, Fuwen Yao, Litong Nie, Chao Wang, Dan Su, Huimin Zhang, Siting Li, Mengfan Tang, Xu Feng, Bin Yu, Zhen Chen, Shimin Wang, Ling Yin, Lisha Mou, Traver Hart, Junjie Chen

Faculty, Staff and Student Publications

DNA damage-activated signaling pathways are critical for coordinating multiple cellular processes, which must be tightly regulated to maintain genome stability. To provide a comprehensive and unbiased perspective of DNA damage response (DDR) signaling pathways, we performed 30 fluorescence-activated cell sorting (FACS)-based genome-wide CRISPR screens in human cell lines with antibodies recognizing distinct endogenous DNA damage signaling proteins to identify critical regulators involved in DDR. We discovered that proteasome-mediated processing is an early and prerequisite event for cells to trigger camptothecin- and etoposide-induced DDR signaling. Furthermore, we identified PRMT1 and PRMT5 as modulators that regulate ATM protein level. Moreover, we discovered …

2022 St. John’S University Biennial Poverty Conference Abstracts, Patrick Griffin, John M. Conry

Journal of Vincentian Social Action

No abstract provided.

Justice House At Niagara University: An Emerging Approach To Teaching Vincentian Social Justice During And After The Covid-19 Pandemic, Kevin A. Hinkley

Journal of Vincentian Social Action

Some commentators have predicted that the disruptive effects of the COVID-19 pandemic will transform the landscape of higher education in the United States. For example, Scott Galloway, Professor of Marketing at NYU Stern School of Business, predicts that most U.S. colleges and universities will either “go out of business or become a shadow of themselves.” Professor Galloway argues that the few elite universities that survive will enter into corporate partnerships with Big Tech companies such as Google, Apple, and Meta. From this perspective, for the overwhelming majority of U.S. colleges and universities there won’t be a “post-pandemic recovery”— at least …

Accepting Educational Responsibility For Social Justice: Homeless Mothers’ And Children’S Need Of Education About Health And Nutrition, Smita Guha

Journal of Vincentian Social Action

The goal is to improve health and nutrition among new mothers and their children who were living in shelters. The mothers received workshops and booklets consisting of information, quick and healthy recipes, and learned how to prepare home-made meals with a low budget. The mothers realized nutritious foods are important for them and their children. They learned how to manage time to make nutritious food at the residence. Children regardless of their background, are our future and we need to pay attention to their needs now so that future problems could be prevented. The significance of this study is immense …

Cancer Clinical Trials: The Role Of Healthcare Providers In Addressing Inequitable Racial/Ethnic Minority Representation In Biomedical Research, Jilian Maxine Jalipa Frianela, Gillian Leasunia Katoanga

Journal of Vincentian Social Action

No abstract provided.

Exploring Sexual Health Education Disparities Among Latina Immigrants In Jackson Heights, N.Y., Maria Camila Lopez, Hira Shafeeq

Journal of Vincentian Social Action

The purpose of the current study is to explore the factors that influence sexual health decisions of female Latina immigrants with low socioeconomic status in an urban area. We aimed to evaluate the possible preventive steps to lower their risk of contracting STDs. The need for this study was highlighted by research findings that suggest that health disparities among Hispanic immigrants have had a significant impact on their poor quality of life due to lack of proper access to medical care and misdiagnosis due to differences in risk factors and manifestations of the disease. Sexual health is a constant issue …

Mental Health Stigma As A Sociocultural Complex Within Panamanian Culture, Arielle Sanders

Journal of Vincentian Social Action

The purpose of this study is to examine mental health stigma within the sociocultural context shared by members of the Panamanian population. Mental health stigma is complex because it manifests itself differently according to the cultural context in which it is experienced. Culture informs individual beliefs, behaviors, and attitudes regarding how a person should live within their immediate household and within society. This social conditioning is accomplished through a variety of means, including the passing down of social norms, traditions, and customs. Ultimately, these cultural characteristics encourage socially acceptable behaviors while simultaneously discouraging undesirable behaviors in order to maintain group …

Demystifying Research For Undergraduate Students: An Avenue To Participate In Mission-Based Research, Hira Shafeeq

Journal of Vincentian Social Action

No abstract provided.

Editors

Journal of Vincentian Social Action

No abstract provided.

Toc

Journal of Vincentian Social Action

No abstract provided.