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Full-Text Articles in Life Sciences

Mtco1-Based Population Structure And Genetic Diversity Of Pacific Oyster Crassostrea Gigas Populations Acquired From Two Farms In South Korea, Thanh T. Biet, Su-Jin Park, Hong-Keun Park, Dongjin Park, Youn-Hee Choi Aug 2023

Mtco1-Based Population Structure And Genetic Diversity Of Pacific Oyster Crassostrea Gigas Populations Acquired From Two Farms In South Korea, Thanh T. Biet, Su-Jin Park, Hong-Keun Park, Dongjin Park, Youn-Hee Choi

Department of Food Science and Technology: Faculty Publications

Since the early 1990s in South Korea, climatic and anthropogenic factors have incurred the reduction of the wild seeds of the Pacific oyster, Crassostrea gigas, which raised concerns about losing genetic diversity and accelerating genetic deterioration. We assessed the genetic diversity of C. gigas populations from two farms (Tongyeong and Gadeokdo) on the southern coast, where about 80% of the cultivated oysters in Korea are produced. Tongyeong showed slightly higher diversity than Gadeokdo, but both populations had a similar genetic structure characterized by low nucleotide diversity. Comparative haplotype analyses provided data supporting genetic features of the populations that include …


Reconstructing 42 Years (1979–2020) Of Great Lakes Surface Temperature Through A Deep Learning Approach, Miraj Kayastha, Tao Liu, Daniel Titze, Timothy C. Havens, Chenfu Huang, Pengfei Xue Aug 2023

Reconstructing 42 Years (1979–2020) Of Great Lakes Surface Temperature Through A Deep Learning Approach, Miraj Kayastha, Tao Liu, Daniel Titze, Timothy C. Havens, Chenfu Huang, Pengfei Xue

Michigan Tech Publications

Accurate estimates for the lake surface temperature (LST) of the Great Lakes are critical to understanding the regional climate. Dedicated lake models of various complexity have been used to simulate LST but they suffer from noticeable biases and can be computationally expensive. Additionally, the available historical LST datasets are limited by either short temporal coverage (<30 >years) or lower spatial resolution (0.25° × 0.25°). Therefore, in this study, we employed a deep learning model based on Long Short-Term Memory (LSTM) neural networks to produce a daily LST dataset for the Great Lakes that spans an unparalleled 42 years (1979–2020) at …


Freshwater And Saline Flood Plain Wetlands Of The North Platte River - Sources And Seasonal Dynamics: Kiowa Wildlife Management Area, Morrill, Ne, Anne M. Matherne Aug 2023

Freshwater And Saline Flood Plain Wetlands Of The North Platte River - Sources And Seasonal Dynamics: Kiowa Wildlife Management Area, Morrill, Ne, Anne M. Matherne

Nebraska Game and Parks Commission: White Papers, Conference Presentations, and Manuscripts

The Kiowa Wildlife Management Area (WMA), a 1 mi² wetland and upland on the North Platte River, was acquired by the Nebraska Game and Parks Commission (NGPC) in 1993. The WMA comprises two distinct wetland types, alkaline and freshwater, both of which provide important wildlife habitat. It was the goal of this project to understand the hydrology controlling the development and maintenance of these wetlands in order to anticipate the affect of management strategies on the wetland complex. The study was designed to develop a comprehensive picture of the hydrogeology of both the fresh and alkaline portions of the WMA, …


Willa Cather Ecological Prairie: An Ecological Overview, Harold G. Nagel Aug 2023

Willa Cather Ecological Prairie: An Ecological Overview, Harold G. Nagel

Nebraska Game and Parks Commission: White Papers, Conference Presentations, and Manuscripts

This report includes data gathered on the ecology of a 610 acre mixed grass prairie in south-central Nebraska over a two year period.

An attempt was made to identify as many of the plant and animal species present and to determine density and standing crop biomass wherever possible, under the time and financial constraints present. Few attempts have been made to develop complete species checklists for both animals and plants in prairies. The data collected are considered baseline conditions against which comparisons can be made after a management plan is carried out.

This study of Cather Prairie had several objectives. …


The Flora Of The Oak-Wooded Drainages At The Timber Point Area, Southeastern Butler County, Nebraska, Steven B. Rolfsmeier Aug 2023

The Flora Of The Oak-Wooded Drainages At The Timber Point Area, Southeastern Butler County, Nebraska, Steven B. Rolfsmeier

Nebraska Game and Parks Commission: White Papers, Conference Presentations, and Manuscripts

The Timber Point Area is a 160-acre recreational/wildlife area occupying to S½ of the SW¼ sec. 22 and the adjacent N½ of the NW¼ sec. 27, T14N R4E. The area is located in the loess-mantled glacial-till hills of southeast Nebraska not far from the terminal moraine of the Pre-Illinoian glacial sheet, one mile south and two miles east of the present town of Brainard. The uplands at Timber Point were apparently in pasture prior to purchase by the NRD, with some cultivated fields occupying the lower ground along a stream valley which southwest to northeast through the property. This small …


The Flora Of Two Oak Drainages At The Red Cedar Area, Southwestern Saunders County, Nebraska, Steven B. Rolfsmeier Aug 2023

The Flora Of Two Oak Drainages At The Red Cedar Area, Southwestern Saunders County, Nebraska, Steven B. Rolfsmeier

Nebraska Game and Parks Commission: White Papers, Conference Presentations, and Manuscripts

The Red Cedar Area is a 175 acre recreational/wildlife area occupying the SE sec. 20, T14N R5E and a small portion of sec. 29 directly to the south. The area is located in the glacial-till hills of southeast Nebraska ca 5 mi. north and 2 mi. west of Valpraiso. The bulk of the area was cultivated farmland prior to purchase by the NRD, and nearly all upland areas here were cultivated cropland, save for some steep oak-wooded drainages on the east side of Hunter’s Slough, which ran northwest to southeast through the property. The creek was dammed after NRD purchase …


The Vascular Plants Of The Woodlands Of South Table Creek In The Vicinity Of The National Arbor Day Center, Nebraska City, Nebraska, Steven B. Rolfsmeier Aug 2023

The Vascular Plants Of The Woodlands Of South Table Creek In The Vicinity Of The National Arbor Day Center, Nebraska City, Nebraska, Steven B. Rolfsmeier

Nebraska Game and Parks Commission: White Papers, Conference Presentations, and Manuscripts

The objective of this study is to describe the composition of the vascular plant flora of a three-quarter mile stretch of woodland along South Table Creek managed by the National Arbor Day Foundation in Nebraska City. This 50-60 acre woodland is representative of the many small tributaries of the Missouri River in southeastern Nebraska, and may represent the only natural “preserve” of native forest on the west side of the Missouri River between Fontenelle Forest and Indian Cave State Park. All naturally-occurring species encountered in this study are listed alphabetically by family at the end of this paper, and a …


The Flora Of Meadowlark Prairie, Northeastern Seward County, Nebraska, Steven B. Rolfsmeier Aug 2023

The Flora Of Meadowlark Prairie, Northeastern Seward County, Nebraska, Steven B. Rolfsmeier

Nebraska Game and Parks Commission: White Papers, Conference Presentations, and Manuscripts

This report is on the flora of the Meadowlark Prairie. The prairie is an approximately 7 acre remnant of virgin tall-grass prairie in extreme northeastern Seward County, Nebraska. The remnant is triangular in shape and lies on a gentle southeast-facing slope with a total relief of 50 ft., along the east boundary of the Meadowlark Recreation Area. The prairie is surrounded on the east side by a small brome-infested prairie remnant and cultivated field off the NRD property, and on the remaining sides by formerly cultivated fields now seeded to native warm-season grasses. Soils in the area are primarily derived …


The Flora And Plant Communities Of The Ceresco Saline Basins, Southern Saunders County, Nebraska, Steven B. Rolfsmeier Aug 2023

The Flora And Plant Communities Of The Ceresco Saline Basins, Southern Saunders County, Nebraska, Steven B. Rolfsmeier

Nebraska Game and Parks Commission: White Papers, Conference Presentations, and Manuscripts

This report is on the flora and plant communities of the Ceresco Saline Basins. The basins are along Rock Creek east of Ceresco and represent the northernmost representatives of the “eastern saline marsh” community in Nebraska. Eastern saline marshland is mostly restricted to the Salt Creek drainage in northern and central Lancaster County, though the Ceresco basins extend a mile or more north into Saunders County in the floodplain of Rock Creek. Some of the wetland in this area is currently under management of the Nebraska Game and Parks Commission, while some of the northernmost portions of the basins are …


Chalcochares Hirsutifemur (Banks) (Hymenoptera: Pompilidae: Pompilinae), A Probable Obligate Parasitoid Of Aptostichus Simon (Araneae: Mygalomorphae: Euctenizidae) In California, Frank E. Kurczewski, Alice J. Abela, Akira Shimizu Aug 2023

Chalcochares Hirsutifemur (Banks) (Hymenoptera: Pompilidae: Pompilinae), A Probable Obligate Parasitoid Of Aptostichus Simon (Araneae: Mygalomorphae: Euctenizidae) In California, Frank E. Kurczewski, Alice J. Abela, Akira Shimizu

Insecta Mundi

Size equivalence, seasonal synchronicity, geospatial sympatry, habitat specificity, and host-search­ing behavior implicate the spider wasp Chalcochares hirsutifemur (Banks) (Hymenoptera: Pompilidae: Pompilinae) as an obligate parasitoid on species of the wafer-lid spider genus Aptostichus Simon (Araneae: Mygalomorphae: Euctenizidae) on coastal sandy back dunes in San Luis Obispo and Santa Barbara coun­ties, CA. This is substantiated by 2010–2022 macrophotographs, videos, and field observations. Such host evidence supports recent unpublished phylogenomic studies that place Chalcochares as a sister genus of the spider wasp tribe Aporini, in which all species are known obligate parasitoids on trapdoor spiders and related Mygalomorphae. Chalcochares hirsutifemur and C. …


Revisión De Las Especies Del Género Eurybia [Illiger, 1807] De Colombia Y Descripción De Nuevos Taxa (Lepidoptera: Riodinidae), Julián A. Salazar E, Luis Miguel Constantino, Gabriel Rodríguez, Efraín R. Henao Aug 2023

Revisión De Las Especies Del Género Eurybia [Illiger, 1807] De Colombia Y Descripción De Nuevos Taxa (Lepidoptera: Riodinidae), Julián A. Salazar E, Luis Miguel Constantino, Gabriel Rodríguez, Efraín R. Henao

Insecta Mundi

Se revisan las especies del género Eurybia Illiger (Lepidoptera: Riodinidae) de Colombia en base al estudio de especimenes depositados en colecciones nacionales publicas y privadas. Como resultado se analizaron 20 taxones y se describen como nuevas a: E. chocoensis nueva especie, E. dardus atlantica nueva subespecie, E. molochina violacea nueva subspecie, E. rubeolata nielseni nueva subspecie y E. rubeolata rufomarginata nueva subspecie. Eurybia dardus fassli Seitz, 1916, E. franciscana caerulescens Druce, 1904 y E. dardus mestiza Salazar, Villalobos y Vargas, 2021 son restituidos a nivel subespecífico. Se crea la nueva combinación de E. rubeolata silaceana basado …


Usa: Wolf Connection And Inclusive, Safe Spaces For All, Patrick Fuery, Kelli Fuery Aug 2023

Usa: Wolf Connection And Inclusive, Safe Spaces For All, Patrick Fuery, Kelli Fuery

CCI Books and Book Chapters

"Wolf Connection is a wolf sanctuary located on the outskirts of a rural town, Acton, California, nestled in the Angeles National Forest. The sanctuary consists of 165 acres of stunning woodland and high desert mountains, including a year-round stream. It is located within a one-hour drive from Los Angeles. Wolf Connection runs a series of programmes based around issues of mental health, addressing social and economic inequality, and providing strategies for resilience and well-being. Wolf Connection identifies the following as its core business activities: Providing Animal Rescue and Wildlife Preservation; At-Risk Youth Education and Empowerment; Community Empowerment; and Environmental Awareness …


Bison Alter The Northern Yellowstone Ecosystem By Breaking Aspen Saplings, Luke E. Painter, Robert L. Beschta, William J. Ripple Aug 2023

Bison Alter The Northern Yellowstone Ecosystem By Breaking Aspen Saplings, Luke E. Painter, Robert L. Beschta, William J. Ripple

Aspen Bibliography

The American bison (Bison bison) is a species that strongly interacts with its environment, yet the effects of this large herbivore on quaking aspen (Populus tremuloides) have received little study. We documented bison breaking the stems of aspen saplings (young aspen > 2 m tall and ≤ 5 cm in diameter at breast height) and examined the extent of this effect in northern Yellowstone National Park (YNP). Low densities of Rocky Mountain elk (Cervus canadensis) after about 2004 created conditions conducive for new aspen recruitment in YNP's northern ungulate winter range (northern range). We sampled …


A Follow-Up Survey To Assess Stakeholders’ Perspectives On Weed Management Challenges And Current Practices In Nebraska, Usa, Shawn T. Mcdonald, Debalin Sarangi, Jennifer M. Rees, Amit J. Jhala Aug 2023

A Follow-Up Survey To Assess Stakeholders’ Perspectives On Weed Management Challenges And Current Practices In Nebraska, Usa, Shawn T. Mcdonald, Debalin Sarangi, Jennifer M. Rees, Amit J. Jhala

Department of Agronomy and Horticulture: Faculty Publications

Stakeholders across the state of Nebraska, USA, were surveyed in 2019–2020 to assess problem weeds and weed management practices in agronomic crops. A total of 420 complete responses were obtained across four Nebraska districts (Northeast, Panhandle, Southeast, and West Central). Accumulated across the state, 65.5% of farmed or scouted crop ground in Nebraska was under no-till production, with the major crops being corn and soybean representing 39.3% and 30.7% of agronomic crop production area, respectively. Palmer amaranth, horseweed, waterhemp, kochia, and giant ragweed were ranked the most problematic weeds. In a 2014–2015 survey, Palmer amaranth was the sixth most problematic …


Saturating Growth Rate Against Phosphorus Concentration Explained By Macromolecular Allocation, Gabrielle Armin, Jongsun Kim, Keisuke Inomura Aug 2023

Saturating Growth Rate Against Phosphorus Concentration Explained By Macromolecular Allocation, Gabrielle Armin, Jongsun Kim, Keisuke Inomura

School of Earth, Environmental, & Marine Sciences Faculty Publications

The saturating relationship between phytoplankton growth rate and environmental nutrient concentration has been widely observed, yet the mechanisms behind the relationship remain elusive. Here, we use a mechanistic model of phytoplankton and show that the saturating relationship between growth rate and phosphorous concentration can be interpreted by intracellular macromolecular allocation. At low nutrient levels, the diffusive nutrient transport linearly increases with the phosphorous concentration, while the internal phosphorous requirement increases with the growth rate, leading to a non-linear increase in the growth rate with phosphorous. This increased phosphorous requirement is due to the increased allocation to biosynthetic and photosynthetic molecules. …


Crabr-Net: A Contextual Relational Attention-Based Recognition Network For Remote Sensing Scene Objective, Jinwei Han, Xiangning Chen Aug 2023

Crabr-Net: A Contextual Relational Attention-Based Recognition Network For Remote Sensing Scene Objective, Jinwei Han, Xiangning Chen

Faculty, Staff and Student Publications

Remote sensing scene objective recognition (RSSOR) plays a serious application value in both military and civilian fields. Convolutional neural networks (CNNs) have greatly enhanced the improvement of intelligent objective recognition technology for remote sensing scenes, but most of the methods using CNN for high-resolution RSSOR either use only the feature map of the last layer or directly fuse the feature maps from various layers in the "summation" way, which not only ignores the favorable relationship information between adjacent layers but also leads to redundancy and loss of feature map, which hinders the improvement of recognition accuracy. In this study, a …


Two New Species Of Guatemalan Colyphus Spinola (Coleoptera: Cleridae: Clerinae), Jacques Rifkind Aug 2023

Two New Species Of Guatemalan Colyphus Spinola (Coleoptera: Cleridae: Clerinae), Jacques Rifkind

Insecta Mundi

Colyphus zacki new species and Colyphus monzoni new species (Coleoptera: Cleridae: Clerinae) are described from Guatemala.

The genus Colyphus Spinola was most recently revised by Ekis (1977), who recognized 16 species, distributed from Mexico to Panama. Since then, four new species have been described (Colyphus hansoni Rifkind, C. ska Rifkind and Barr, C. lamed Rifkind, and C. martinezi Rifkind) and four species (Enoclerus guatemalensis (Gor­ham), E. pictus (Gorham), E. rutilus (Gorham), and Thanasimus subviolaceus Gorham) have been transferred to the genus (Rifkind and Barr 2011; Rifkind 2014). With the two new species described herein, the total known Colyphus …


One Cluster Per Condition Is Not A Valid Design In Cluster-Randomized Trials Comment On Wang Et Al The Effect Of Different Physical Exercise Programs On Physical Fitness Among Preschool Children: A Cluster-Randomized Controlled Trial Int J Environ Res Public Health 2023, 20, 4254, Yasaman Jamshidi-Naeini, Armando Pena, Abu Bakkar Siddique, Andrew W Brown, David B Allison Aug 2023

One Cluster Per Condition Is Not A Valid Design In Cluster-Randomized Trials Comment On Wang Et Al The Effect Of Different Physical Exercise Programs On Physical Fitness Among Preschool Children: A Cluster-Randomized Controlled Trial Int J Environ Res Public Health 2023, 20, 4254, Yasaman Jamshidi-Naeini, Armando Pena, Abu Bakkar Siddique, Andrew W Brown, David B Allison

Children’s Nutrition Research Center Staff Publications

Wang et al. [...].


Mapping The Evolution Of T Cell States During Response And Resistance To Adoptive Cellular Therapy, Pavan Bachireddy, Elham Azizi, Cassandra Burdziak, Vinhkhang N Nguyen, Christina S Ennis, Cameron Y Park, Shuqiang Li, Satyen H Gohil, Neil G Ruthen, Zhongqi Ge, Derin B Keskin, Nicoletta Cieri, Kenneth J Livak, Haesook T Kim, Donna S Neuberg, Robert J Soiffer, Jerome Ritz, Edwin P Alyea, Dana Pe'er, Catherine J Wu Aug 2023

Mapping The Evolution Of T Cell States During Response And Resistance To Adoptive Cellular Therapy, Pavan Bachireddy, Elham Azizi, Cassandra Burdziak, Vinhkhang N Nguyen, Christina S Ennis, Cameron Y Park, Shuqiang Li, Satyen H Gohil, Neil G Ruthen, Zhongqi Ge, Derin B Keskin, Nicoletta Cieri, Kenneth J Livak, Haesook T Kim, Donna S Neuberg, Robert J Soiffer, Jerome Ritz, Edwin P Alyea, Dana Pe'er, Catherine J Wu

Faculty, Staff and Student Publications

No abstract provided.


Hypothyroidism Following Radiotherapy For Head And Neck Cancer: A Systematic Review Of The Literature And Opportunities To Improve The Therapeutic Ratio, Michael K Rooney, Lauren M Andring, Kelsey L Corrigan, Vincent Bernard, Tyler D Williamson, Adam S Garden, Anna Lee, Amy C Moreno, William H Morrison, Jack Phan, David I Rosenthal, Michael Spiotto, Steven J Frank Aug 2023

Hypothyroidism Following Radiotherapy For Head And Neck Cancer: A Systematic Review Of The Literature And Opportunities To Improve The Therapeutic Ratio, Michael K Rooney, Lauren M Andring, Kelsey L Corrigan, Vincent Bernard, Tyler D Williamson, Adam S Garden, Anna Lee, Amy C Moreno, William H Morrison, Jack Phan, David I Rosenthal, Michael Spiotto, Steven J Frank

Faculty, Staff and Student Publications

(1) Background: Radiotherapy (RT) is a central component for the treatment of many head and neck cancers. In this systematic review of the literature, we aimed to characterize and quantify the published evidence on RT-related hypothyroidism, including estimated incidence, clinical risk factors, and dosimetric parameters that may be used to guide clinical decision making. Furthermore, we aimed to identify potential areas of improvement in the prevention and clinical management of RT-induced hypothyroidism, including the role of modern advanced therapeutic techniques. (2) Methods: We conducted a systemic review of the literature in accordance with Preferred Reporting Items for Systematic Reviews and …


Bcl-2 Inhibition Combined With Pparα Activation Synergistically Targets Leukemic Stem Cell-Like Cells In Acute Myeloid Leukemia, Chendi Xie, Hui Zhou, Dongmei Qin, Huijian Zheng, Yuanfang Tang, Jie Zhou, Xinxin Yu, Hongpeng Duan, Yong Zhou, Zhifeng Li, Zhihong Fang, Yiming Luo, Bing Z Carter, Bing Xu, Jie Zha Aug 2023

Bcl-2 Inhibition Combined With Pparα Activation Synergistically Targets Leukemic Stem Cell-Like Cells In Acute Myeloid Leukemia, Chendi Xie, Hui Zhou, Dongmei Qin, Huijian Zheng, Yuanfang Tang, Jie Zhou, Xinxin Yu, Hongpeng Duan, Yong Zhou, Zhifeng Li, Zhihong Fang, Yiming Luo, Bing Z Carter, Bing Xu, Jie Zha

Faculty, Staff and Student Publications

Persistence of leukemic stem cells (LSCs) is one of the determining factors to acute myeloid leukemia (AML) treatment failure and responsible for the poor prognosis of the disease. Hence, novel therapeutic strategies that target LSCs are crucial for treatment success. We investigated if targeting Bcl-2 and peroxisome proliferator activated receptor α (PPARα), two distinct cell survival regulating mechanisms could eliminate LSCs. This study demonstrate that the Bcl-2 inhibitor venetoclax combined with the PPARα agonist chiglitazar resulted in synergistic killing of LSC-like cell lines and CD34+ primary AML cells while sparing their normal counterparts. Furthermore, the combination regimen significantly suppressed AML …


An Evolutionarily Nascent Architecture Underlying The Formation And Emergence Of Biomolecular Condensates, Nima Jaberi-Lashkari, Byron Lee, Fardin Aryan, Eliezer Calo Aug 2023

An Evolutionarily Nascent Architecture Underlying The Formation And Emergence Of Biomolecular Condensates, Nima Jaberi-Lashkari, Byron Lee, Fardin Aryan, Eliezer Calo

Faculty, Staff and Student Publications

Biomolecular condensates are implicated in core cellular processes such as gene regulation and ribosome biogenesis. Although the architecture of biomolecular condensates is thought to rely on collective interactions between many components, it is unclear how the collective interactions required for their formation emerge during evolution. Here, we show that the structure and evolution of a recently emerged biomolecular condensate, the nucleolar fibrillar center (FC), is explained by a single self-assembling scaffold, TCOF1. TCOF1 is necessary to form the FC, and it structurally defines the FC through self-assembly mediated by homotypic interactions of serine/glutamate-rich low-complexity regions (LCRs). Finally, introduction of TCOF1 …


Hypothyroidism Following Radiotherapy For Head And Neck Cancer: A Systematic Review Of The Literature And Opportunities To Improve The Therapeutic Ratio, Michael K Rooney, Lauren M Andring, Kelsey L Corrigan, Vincent Bernard, Tyler D Williamson, Adam S Garden, Anna Lee, Amy C Moreno, William H Morrison, Jack Phan, David I Rosenthal, Michael Spiotto, Steven J Frank Aug 2023

Hypothyroidism Following Radiotherapy For Head And Neck Cancer: A Systematic Review Of The Literature And Opportunities To Improve The Therapeutic Ratio, Michael K Rooney, Lauren M Andring, Kelsey L Corrigan, Vincent Bernard, Tyler D Williamson, Adam S Garden, Anna Lee, Amy C Moreno, William H Morrison, Jack Phan, David I Rosenthal, Michael Spiotto, Steven J Frank

Faculty, Staff and Student Publications

(1) Background: Radiotherapy (RT) is a central component for the treatment of many head and neck cancers. In this systematic review of the literature, we aimed to characterize and quantify the published evidence on RT-related hypothyroidism, including estimated incidence, clinical risk factors, and dosimetric parameters that may be used to guide clinical decision making. Furthermore, we aimed to identify potential areas of improvement in the prevention and clinical management of RT-induced hypothyroidism, including the role of modern advanced therapeutic techniques. (2) Methods: We conducted a systemic review of the literature in accordance with Preferred Reporting Items for Systematic Reviews and …


Addendum: Transformative Reimagination: A Framework For A Vincentian College Of Business, Krieg Tidemann, Madhurima (Rima) Bhattacharyay, Kris Principe Aug 2023

Addendum: Transformative Reimagination: A Framework For A Vincentian College Of Business, Krieg Tidemann, Madhurima (Rima) Bhattacharyay, Kris Principe

Journal of Vincentian Social Action

The mission identity and intellectual tradition of Vincentian schools of business affords a unique opportunity for these institutions to produce business leaders prepared to address systemic breakdowns in business ethics and corporate social responsibility. In order to achieve this goal, this paper proposes the HEET (Hire Encourage Equip Train) framework for mission integration. At the heart of the HEET framework is a recognition that successful mission integration requires college-level administrators who promote mission integration throughout the curriculum and center its importance within the strategic operations of the school of business. As every component of HEET centers on developing an industry-leading …


Combination Treatment Of Pembrolizumab With Dc-Cik Cell Therapy For Advanced Hepatocellular Carcinoma: A Case Report, Shao Min Huang, Long-Bin Jeng, Woei-Cherng Shyu, Hung-Yao Chen Aug 2023

Combination Treatment Of Pembrolizumab With Dc-Cik Cell Therapy For Advanced Hepatocellular Carcinoma: A Case Report, Shao Min Huang, Long-Bin Jeng, Woei-Cherng Shyu, Hung-Yao Chen

BioMedicine

Background: Recently, immunotherapy has emerged as a promising method for advanced HCC treatment. There are several clinical trials and meta-analyses of immune checkpoint inhibitors and immune cell therapy, but clinical evidence on the combination of these two therapies is lacking. Case description: A 66-year-old man with chronic hepatitis B-related cirrhosis complained of acute abdominal pain in an emergency department of a hospital. On exams, there was a palpable mass in the right upper quadrant of his abdomen. Contrast-enhanced abdominal computed tomography showed a large tumor in the right lobe, 13 cm x 17cm in size, and right portal vein thrombosis. …


Hipoxia Modulates The Secretion Of Growth Factors In Of Human Umbilical Cord-Derived Mesenchymal Stem Cells, Arfianti Arfianti, Ulfah Ulfah, Leopold Sampetua Hutabarat, Agnes Ivana G, Anisa Dwi Budiarti, Nabilla Sonia Sahara, Nicko Pisceski Kusika Saputra Aug 2023

Hipoxia Modulates The Secretion Of Growth Factors In Of Human Umbilical Cord-Derived Mesenchymal Stem Cells, Arfianti Arfianti, Ulfah Ulfah, Leopold Sampetua Hutabarat, Agnes Ivana G, Anisa Dwi Budiarti, Nabilla Sonia Sahara, Nicko Pisceski Kusika Saputra

BioMedicine

Background: Mesenchymal stem cell (MSC) has great potential as therapies due its ability to regenerate tissue damage and promote tissue homeostasis. Preconditioning of MSC in low oxygen concentration has been shown to affect the therapeutic potential of these cells. This study aimed to compare the characteristic and secretion of trophic factors of MSCs cultured under hypoxia and normoxia. Methods: MSCs were isolated from Wharton's jelly of human umbilical cord (UC) tissue by explant method and characterized by flow cytometry. Following 24 hours of CoCl2induced hypoxic culture, the viability and metabolic activity of MSC were analyzed by trypan blue exclusion test …


Evaluation Of Sars-Cov-2 Infection Risks After Primary Vaccination With Bnt162b2, Bbibp-Corv, Or Chadox1-Ncov-19 And After Homologous And Heterologous Booster Vaccinations With These Vaccines And Evaluation Of Sars-Cov-2 Reinfection Profiles, Soulandi Djorwé, Amale Bousfiha, Néhémie Nzoyikorera, Joseph Nyandwi, Bellamine Kawthar, Abderrahim Malki Aug 2023

Evaluation Of Sars-Cov-2 Infection Risks After Primary Vaccination With Bnt162b2, Bbibp-Corv, Or Chadox1-Ncov-19 And After Homologous And Heterologous Booster Vaccinations With These Vaccines And Evaluation Of Sars-Cov-2 Reinfection Profiles, Soulandi Djorwé, Amale Bousfiha, Néhémie Nzoyikorera, Joseph Nyandwi, Bellamine Kawthar, Abderrahim Malki

BioMedicine

Background: The emergence of SARS-CoV-2 variants has significantly increased the number of cases of COVID-19 among vaccinated individuals, raising concerns about the effectiveness of current vaccines. The aim of this study was to analyze the SARS-CoV-2 infection risks after primary vaccination with BNT162b2, BBIBP-CorV, or ChAdOx1-nCOV-19 and after homologues and heterologous booster vaccinations with these vaccines, as well as the profiles of reinfected patients. Methods: We analyzed retrospectively 1082 patients vaccinated or unvaccinated with BNT162b2, BBIBP-CorV, and/or ChAdOx1nCoV-19 vaccines to determine their SARS-CoV2 infection statuses using the reverse transcription-polymerase chain reaction (RT-PCR) in addition to their clinical features. The infection …


Evaluation Of Antibacterial Efficacy Of Lawsonia Inermis Linn (Henna) On Periodontal Pathogens Using Agar Well Diffusion And Broth Microdilution Methods: An In-Vitro Study, Şevki Güler, Damla Torul, Sevda Kurt-Bayrakdar, Emine Kübra Tayyarcan, Çağrı Çamsarı, İsmail Hakkı Boyacı Aug 2023

Evaluation Of Antibacterial Efficacy Of Lawsonia Inermis Linn (Henna) On Periodontal Pathogens Using Agar Well Diffusion And Broth Microdilution Methods: An In-Vitro Study, Şevki Güler, Damla Torul, Sevda Kurt-Bayrakdar, Emine Kübra Tayyarcan, Çağrı Çamsarı, İsmail Hakkı Boyacı

BioMedicine

Background: Although widely explored in medicine, limited evidence exists in the literature regarding the efficacy of Lawsonia inermis Linn (henna) in the dental field. Aim: This study aimed to investigate the antibacterial effect of henna on Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis in vitro. Methods: The agar well diffusion and broth microdilution methods were used to evaluate the antibacterial effect of henna extracts. Dimethyl sulfoxide was used to prepare the ethanol extract of henna, and distilled water was used to prepare the water extract. For both ethanol and water extracts, 4 different concentrations were prepared as 15, 30, 60, and 120 …


Age-Specific Percentile-Based Prostate-Specific Antigen Cutoff Values Predict The Risk Of Prostate Cancer: A Single Hospital Observation, Teng-Fu Hsieh, Hung-Lin Chen, Ying-Fang Hsia, Che-Chen Lin, Hsiu-Yin Chiang, Min-Yen Wu, Sheng-Hsuan Chen, Po-Fan Hsieh, Hsi-Chin Wu, Han Chang, Chin-Chi Kuo Aug 2023

Age-Specific Percentile-Based Prostate-Specific Antigen Cutoff Values Predict The Risk Of Prostate Cancer: A Single Hospital Observation, Teng-Fu Hsieh, Hung-Lin Chen, Ying-Fang Hsia, Che-Chen Lin, Hsiu-Yin Chiang, Min-Yen Wu, Sheng-Hsuan Chen, Po-Fan Hsieh, Hsi-Chin Wu, Han Chang, Chin-Chi Kuo

BioMedicine

Background Testing for prostate-specific antigen (PSA) is often recommended for men with a potential risk of prostate cancer (PCa) before requiring advanced examination. However, the best PSA cutoff value remains controversial. Object We compared the predictive performance of age-specific percentile-based PSA thresholds with a conventional cutoff of >4 ng/mL for the risk of PCa. Methods We included men who received PSA measurements between 2003 and 2017 in a medical center in Taiwan. Logistic regression modeling was used to assess the association between age-specific percentile-based PSA thresholds and PCa risk in age subgroups. We further applied C-statistic and decision curve analysis …


Endometrial Fluid Biomarkers And Their Potential As Predictors Of Successful Embryo Implantation, Ana Rita Alves, Margarida Figueiredo Dias, Margarida Silvestre Aug 2023

Endometrial Fluid Biomarkers And Their Potential As Predictors Of Successful Embryo Implantation, Ana Rita Alves, Margarida Figueiredo Dias, Margarida Silvestre

BioMedicine

Background: Embryo implantation is a complex biological process which requires synchronized dialogue between the receptive endometrium and the blastocyst. The endometrium, however, is only receptive to embryo implantation for a very short period. Recurrent implantation failure (RIF) is a major challenge in assisted reproductive techniques mainly due to impaired receptivity, but there is still a need for a reliable and valid clinical test to assess endometrial receptiveness, especially at embryo transfer time. The aim of this review is to investigate what is currently known about the contribution of endometrial fluid (EF) to endometrial receptivity by identifying its potential biomarkers. Methods: …