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Articles 35041 - 35070 of 256031
Full-Text Articles in Life Sciences
Pestfacts Wa Issue 19 - October 2023, Alan Lord, Cindy L. Webster, Daniel Huberli, Kylie Chambers
Pestfacts Wa Issue 19 - October 2023, Alan Lord, Cindy L. Webster, Daniel Huberli, Kylie Chambers
PestFacts WA
PestFacts WA Issue 19 - October 2023 contents:
- Native budworm monitoring and management in maturing crops
- Barley leaf rust
- Fusarium crown rot
Pestfacts Wa Issue 20 - October 2023, Cindy L. Webster, Dusty Severtson, Andrew Phillips, Christiaan Valentine
Pestfacts Wa Issue 20 - October 2023, Cindy L. Webster, Dusty Severtson, Andrew Phillips, Christiaan Valentine
PestFacts WA
PestFacts WA Issue 20 - October 2023 contents:
- Armyworm in cereals
- Diamondback moth surveillance summary
- WA’s native budworm trapping program finishes next week
- Free seed testing for virus infections in pulses
Factors Influencing Instructors’ Adoption And Continued Use Of Computing Science Technologies: A Case Study In The Context Of Cell Collective, Changsoo Song, Resa M. Helikar, Wendy Smith, Tomáš Helikar
Factors Influencing Instructors’ Adoption And Continued Use Of Computing Science Technologies: A Case Study In The Context Of Cell Collective, Changsoo Song, Resa M. Helikar, Wendy Smith, Tomáš Helikar
Department of Biochemistry: Faculty Publications
Acquiring computational modeling and simulation skills has become ever more critical for students in life sciences courses at the secondary and tertiary levels. Many modeling and simulation tools have been created to help instructors nurture those skills in their classrooms. Understanding the factors that may motivate instructors to use such tools is crucial to improve students’ learning, especially for having authentic modeling and simulation learning experiences. This study designed and tested a decomposed technology acceptance model in which the perceived usefulness and perceived ease of use constructs are split between the teaching and learning sides of the technology to examine …
Acmaeodera (Coleoptera: Buprestidae): A New Species Of Acmaeodera Eschscholtz, 1829 From The Southwestern United States, With Three New Synonymies, New State And Host Records, And A Key To Species Occurring East Of The Rocky Mountain States, Jason A. Hansen
Insecta Mundi
Acmaeodera natlovei new species (Coleoptera: Buprestidae) is described from the southwestern United States. Details of phenology, geographic range, larval, flower and adult host plants, and similar species are discussed. Acmaeodera yuccavora Knull, 1962 is newly synonymized with Acmaeodera conoidea Fall, 1899. Acmaeodera thoracata Knull, 1974 and A. bryanti Van Dyke, 1953 are newly synonymized with Acmaeodera neoneglecta Fisher, 1949. New state and host records are reported for United States. A key to the 46 species of Acmaeodera occurring east of the Rocky Mountain states is provided.
Acmaeodera Eschscholtz, 1829 is one of the most speciose buprestid genera in America …
Using Crispr To Generate Integrated Ssa4-Gfp Reporter Strains, Emma Norman, Rebecca Adams
Using Crispr To Generate Integrated Ssa4-Gfp Reporter Strains, Emma Norman, Rebecca Adams
Science University Research Symposium (SURS)
Using CRISPR to Generate Integrated Ssa4-GFP Reporter Strains
Emma Norman, Rebecca Adams, PhD
Proteins play critical roles in numerous cellular processes. In order to synthesize these important molecules in eukaryotes, DNA is first transcribed into an intermediate molecule, mRNA, in the nucleus. The export of mRNA from its origin in the nucleus to the site of protein production, the cytoplasm, is an integral step in protein synthesis. When a cell is subjected to stress, such as heat shock, most mRNA export is halted, as export proteins are inactivated, and cellular machinery is redirected towards recovery. However, particular transcripts, including the …
Inflammasome Activation And Pyroptosis Mediate Coagulopathy And Inflammation In Salmonella Systemic Infection, Ankit Pandeya, Yan Zhang, Jian Cui, Ling Yang, Jeffery Li, Guoying Zhang, Congqing Wu, Zhenyu Li, Yinan Wei
Inflammasome Activation And Pyroptosis Mediate Coagulopathy And Inflammation In Salmonella Systemic Infection, Ankit Pandeya, Yan Zhang, Jian Cui, Ling Yang, Jeffery Li, Guoying Zhang, Congqing Wu, Zhenyu Li, Yinan Wei
Saha Cardiovascular Research Center Faculty Publications
Inflammasome activation is a critical defense mechanism against bacterial infection. Previous studies suggest that inflammasome activation protects against Salmonella oral infection. Here we find inflammasome activation plays a critical role in the pathogenesis of Salmonella systemic infection. We show that in a systemic infection model by i.p. injection of Salmonella, deficiency of caspase-1 or gasdermin-D prolonged survival time, reduced plasma concentrations of the proinflammatory cytokines IL-1β, IL-6 and TNFα. These deficiencies also protected against coagulopathy during Salmonella infection as evidenced by diminished prolongation of prothrombin time and increase in plasma thrombin-antithrombin complex concentrations in the caspase-1 or gasdermin-D deficient mice. …
Community Complexity Of A Pollination Network: Analysis Of Plant-Pollinator Interactions In The Eastern Ecuadorian Cloud Forest, Anisa López-Ruiz
Community Complexity Of A Pollination Network: Analysis Of Plant-Pollinator Interactions In The Eastern Ecuadorian Cloud Forest, Anisa López-Ruiz
Independent Study Project (ISP) Collection
Global declines in pollinators and temporal/spatial mismatches between plants and pollinators threaten the integrity of plant-pollinator networks. Ecological network analysis provides a powerful framework for understanding the dynamics of plant-pollinator networks and measures of community complexity that can help inform areas of priority in conservation. This study observed a plant-pollinator network in a secondary forest close to the Río Zuñac Reserve in the eastern Ecuadorian cloud forest to identify assemblages of plants and pollinators and evaluate measures of community complexity, including specialization and nestedness. Flowering plants were identified and observed along a 1.2 km transect, and floral visitors to these …
Friends In High Places: Establishing Pollination Networks For The Páramos Of Central Ecuador, Emma Diaz
Friends In High Places: Establishing Pollination Networks For The Páramos Of Central Ecuador, Emma Diaz
Independent Study Project (ISP) Collection
Well-known for being a global biodiversity hotspot, the Andean Páramos hosts a unique array of floristic diversity seen nowhere else in the world (Luteyn, n.d.). With the resiliency of this ecosystem dependent on the successful reproduction of these plants, it is crucial to understand the pollination network which sustains them. Modern-day research has outlined networks in the Chilean, Venezuelan, and Argentinean Páramos, but one has yet to be defined for Ecuador, despite being the suspected home to nearly half of floristic diversity in the Páramos (Arroyo et al., 1985; Pelayo et al., 2021; Medan et al., 2023; Caranqui et al., …
Extent Of The 2023 Coral Bleaching Event In The Nargana Region Of Guna Yala, Panama, Brydon Deanna Hollander
Extent Of The 2023 Coral Bleaching Event In The Nargana Region Of Guna Yala, Panama, Brydon Deanna Hollander
Independent Study Project (ISP) Collection
Coral reefs are diverse marine ecosystems that exist in tropical ecosystems all over the world. They provide a myriad of ecological services that are vital for marine organism biodiversity and human coastal communities. A major threat to coral reefs is a rise in sea surface temperature that causes coral bleaching. The effect of a coral bleaching event in Nargana, Guna Yala will be investigated to examine how the health status of coral reef ecosystems are being impacted. To guide these efforts, the extent of coral bleaching will be measured along with whether sea surface temperature (SST), human concentration, and El …
Variation Of Carbon Stock Of Boca Del Drago Mangrove Forests Based On Salinity And Seaward Proximity, Fiona Wyrtzen
Variation Of Carbon Stock Of Boca Del Drago Mangrove Forests Based On Salinity And Seaward Proximity, Fiona Wyrtzen
Independent Study Project (ISP) Collection
Mangrove forests, at the intersection of land and sea, are considered one of the most important marine environments for their variety of ecosystem services and their ability to sequester large amounts of carbon in their biomass and adjacent soils. With a changing climate, many of the abiotic and biotic factors influencing mangroves will begin to shift, potentially impacting resilience, growth capacity, and distribution of mangroves worldwide. This study aimed to examine the influence of changing salinity on the carbon stock capacity for Rhizophora mangle and Laguncularia racemosa forests, and the distribution of biomass in each species relative to salinity in …
Assessing The Performance Of Agricultural Systems In The Inland And Coastal Regions Of Northern Portugal Using Indicators: Establishing The Foundation Towards Better Agricultural Practices, Genevieve Gehlken
Independent Study Project (ISP) Collection
This study conducts a comprehensive evaluation of agricultural systems in the distinct coastal and inland regions of Northern Portugal. Employing key indicators, including soil erosion, nitrogen surplus, irrigation practices, Agricultural Gross Domestic Product (GDP), and crop yield, the analysis reveals statistically significant disparities and unique challenges in each region. The coastal areas, marked by higher agricultural GDP, exhibit distinct economic dependencies on agriculture, while the inland regions face challenges related to water scarcity, soil erosion, and rural isolation. The looming threat of climate change adds complexity to these dynamics, further highlighting the need for region-specific, sustainable agricultural practices. In the …
The Truth Behind Avocado Expansion In The Algarve: A Synthesis Of Public, Environmental Associations, And Government Perspectives And Response, Mandy Ausman
Independent Study Project (ISP) Collection
Avocado expansion has exponentially increased in the Algarve region of southern Portugal in recent years. The surge in expansion has provoked contention and discrepancy in the media regarding how and if avocado production can persist in the water-scarce region due to worsening drought conditions related to climate change coupled with the fruit’s significant water footprint. This paper aims to synthesize the arguments and response of the public, environmental associations, and government agencies to the expansion of avocado production in the water- scarce region of the Algarve, highlight the region’s current challenges of avocado expansion and water management regulation, and analyze …
Shinyfruit: Interactive Fruit Phenotyping Software And Its Application In Blackberry, T. Mason Chizk, Jackie A. Lee, John R. Clark, Margaret L. Worthington
Shinyfruit: Interactive Fruit Phenotyping Software And Its Application In Blackberry, T. Mason Chizk, Jackie A. Lee, John R. Clark, Margaret L. Worthington
Horticulture Faculty Publications and Presentations
Introduction: Horticultural plant breeding programs often demand large volumes of phenotypic data to capture visual variation in quality of harvested products. Increasing the throughput potential of phenomic pipelines enables breeders to consider data-hungry molecular breeding strategies such as genome-wide association studies and genomic selection.
Methods: We present an R-based web application called ShinyFruit for image-based phenotyping of size, shape, and color-related qualities in fruits and vegetables. Here, we have demonstrated one potential application for ShinyFruit by comparing its estimates of fruit length, width, and red drupelet reversion (RDR) with ImageJ and analogous manual phenotyping techniques in a population of blackberry …
Unveiling The Impact: Mexico's Decree On Genetically Modified Corn And Its Ramifications On Food Security, Lauren Mcshea
Unveiling The Impact: Mexico's Decree On Genetically Modified Corn And Its Ramifications On Food Security, Lauren Mcshea
Independent Study Project (ISP) Collection
This research delves into the repercussions of Mexico's presidential decree in late 2020, which imposed a ban on the human consumption of genetically modified (GM) corn by January 2024. In a trade dispute under the United States-Mexico-Canada Agreement (USMCA), the decree has sparked tensions between Mexico and the United States, particularly concerning the disruption of GM corn exports. Beyond trade dynamics, the study aims to address the broader impact on Mexico's food security landscape, exploring the intricate connections between the ban and various factors, including agricultural practices, economic implications, and shifts in the corn market dynamics. This research seeks to …
Organism Communities On Giant Clam Shells As Compared To The Surrounding Substrate In Reefs Around Lizard Island, Queensland, Gayatri Singla
Organism Communities On Giant Clam Shells As Compared To The Surrounding Substrate In Reefs Around Lizard Island, Queensland, Gayatri Singla
Independent Study Project (ISP) Collection
Coral reef ecosystems are facing destruction at the hands of anthropogenic climate change. Therefore, it is essential that we move to better understand the ecosystem functions of the organisms present in reefs. One such family whose ecosystem function we are unfamiliar with are the giant clams (family Cardiidae). As unique and abundant macrofauna, they have the potential to play an important role in their environment. The goal of our study was to determine how giant clams function as settlement substrata. We conducted 151 observational surveys of epibionts residing on living giant clam shells and of the organism communities in the …
Qtls And Candidate Loci Associated With Drought Tolerance Traits Of Kaybonnet X Zhe733 Recombinant Inbred Lines Rice Population, Yheni Dwiningsih, Julie Thomas, Anuj Kumar, Chirag Gupta, Navdeep Gill, Charles Ruiz, Jawaher Alkahtani, Niranjan Baisakh, Andy Pereira
Qtls And Candidate Loci Associated With Drought Tolerance Traits Of Kaybonnet X Zhe733 Recombinant Inbred Lines Rice Population, Yheni Dwiningsih, Julie Thomas, Anuj Kumar, Chirag Gupta, Navdeep Gill, Charles Ruiz, Jawaher Alkahtani, Niranjan Baisakh, Andy Pereira
Crop, Soil and Environmental Sciences Faculty Publications and Presentations
Rice is the most important staple crop for the sustenance of the world’s population, and drought is a major factor limiting rice production. Quantitative trait locus (QTL) analysis of drought-resistance-related traits was conducted on a recombinant inbred line (RIL) population derived from the self-fed progeny of a cross between the drought-resistant tropical japonica U.S. adapted cultivar Kaybonnet and the drought-sensitive indica cultivar ZHE733. K/Z RIL population of 198 lines was screened in the field at Fayetteville (AR) for three consecutive years under controlled drought stress (DS) and well-watered (WW) treatment during the reproductive stage. The effects of DS were quantified …
Search, The Jackson Laboratory
Nebraska Crop Budgets 2024, Robert N. Klein, Glennis Mcmclure
Nebraska Crop Budgets 2024, Robert N. Klein, Glennis Mcmclure
Department of Agricultural Economics: Presentations, Working Papers, and Gray Literature
The 2024 Nebraska Crop budget projections were created using cropping practice norms for many producers in Nebraska. However, each individual farming operation is unique, and these budgets should be used only as a guide. The budgets for 2024 are available in the Agricultural Budget Calculator program at:https://agbudget.unl.edu/. To modify these budgets, you can download UNL budgets into your ABC program account or create your own. In addition, the reports for each of the 2024 crop budgets are saved as printable (PDF) files. See also the new budget calculator at https://cap.unl.edu/abc.
The following individuals contributed to these budgets …
Patterns Of Cytonuclear Discordance And Divergence Between Subspecies Of The Scarlet Macaw (Ara Macao) In Central America, Matthew L. Aardema, Kari L. Schmidt, George Amato
Patterns Of Cytonuclear Discordance And Divergence Between Subspecies Of The Scarlet Macaw (Ara Macao) In Central America, Matthew L. Aardema, Kari L. Schmidt, George Amato
Department of Biology Faculty Scholarship and Creative Works
The scarlet macaw, Ara macao, is a neotropical parrot that contains two described subspecies with broadly discrete geographical distributions. One subspecies, A. m. macao, is found from South America north into southwestern Costa Rica, while the second subspecies, A. m. cyanoptera, is found from eastern Costa Rica north into central Mexico. Our previous research using mitochondrial data to examine phylogeographical divergence across the collective range of these two subspecies concluded that they represent distinct evolutionary entities, with minimal contemporary hybridization between them. Here we further examine phylogenetic relationships and patterns of genetic variation between these two subspecies using a dataset …
Wright State University's Celebration Of Student Research, Scholarship & Creative Activities From Thursday, October 26, 2023, Wright State University
Wright State University's Celebration Of Student Research, Scholarship & Creative Activities From Thursday, October 26, 2023, Wright State University
Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Abstract Books
The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's Celebration of Student Research, Scholarship & Creative Activities on October 26, 2023.
Louisiana Agriculture Magazine, Fall 2023, Lsu Agcenter
Louisiana Agriculture Magazine, Fall 2023, Lsu Agcenter
Louisiana Agriculture
Hemp has been cultivated for thousands of years. It was grown widely in the United States until the mid-1900s, when laws limited the growth of hemp and later banned it entirely. Since the 2018 Farm Bill removed legal barriers to growing the crop, Louisiana created a structure to regulate hemp farming in 2019.
Because little information existed about hemp in Louisiana, the LSU AgCenter created the Industrial Hemp Working Group to study the crop, create production practices and help growers interested in this ancient plant.
This issue of Louisiana Agriculture focuses on the work of these researchers and the growers …
Demographic Analysis Of The Human Communities Of Tangier And Smith Islands: Part Iii, Lyndsey Brown, Alexzandria Davis, Shae Sloan, Melissa C. Rhoten, Mark Fink
Demographic Analysis Of The Human Communities Of Tangier And Smith Islands: Part Iii, Lyndsey Brown, Alexzandria Davis, Shae Sloan, Melissa C. Rhoten, Mark Fink
Fall Showcase for Research and Creative Inquiry
Demography is defined as the study of population characteristics, such as age structure, sex ratio, and growth rate and also seeks to explain the underlying processes responsible for these characteristics. Populations change with time through the combined effects of births/deaths and immigration/emigration. Although all four of these processes are extremely important, this project focuses on births, survival, and deaths. We collected and analyzed records of age at death that have been preserved in the cemeteries of Tangier Island, Virginia and Smith Island, Maryland. Following our experiences on these Chesapeake islands, we developed hypotheses and used survivorship curves to focus on …
Loggerhead Shrike Occurrence Along Urban Gradients In South Carolina’S Coastal Plain, Michelle A. Krauser, Christopher E. Hill
Loggerhead Shrike Occurrence Along Urban Gradients In South Carolina’S Coastal Plain, Michelle A. Krauser, Christopher E. Hill
Biology
The urban landscape is understudied compared to less developed ecosystems, despite providing suitable habitat for wildlife, including some species of grassland birds. Loggerhead Shrikes (Lanius ludovicianus) are predatory songbirds that frequent grasslands and have been observed using grassy areas in developed and more natural landscapes, yet remain largely unstudied in developed landscapes. We investigated the effects of development, measured as impervious surface percentage, on Loggerhead Shrike occurrence in urban areas in South Carolina, U.S.A, and also tracked canopy cover (%), highway density (m/ha), non-highway road density (m/ha), total road density (m/ha), and powerline density (m/ha). The first author searched 300 …
Brilliant Bird Brains: Object Recognition In Herring Gulls (Larus Argentatus Smithsonianus), Kristen M. Covino, F. Dylan Titmuss, Joseph E. Brosseau, Dora C. Donacik, Maddie E. Ellms, Alyssa R. Nowicki, Daphne Okuyama, Jessica M. Robinson, Katherine A. Schickfus, Eliza L. Stanley, Mary Elizabeth Everett
Brilliant Bird Brains: Object Recognition In Herring Gulls (Larus Argentatus Smithsonianus), Kristen M. Covino, F. Dylan Titmuss, Joseph E. Brosseau, Dora C. Donacik, Maddie E. Ellms, Alyssa R. Nowicki, Daphne Okuyama, Jessica M. Robinson, Katherine A. Schickfus, Eliza L. Stanley, Mary Elizabeth Everett
Biology Faculty Works
The ability to recognize and associate objects with prior experiences has been demonstrated in several avian taxa. Corvids, for example, recognize visual stimuli associated with negative previous experiences and will modify their behavioral responses according to the level of perceived threat. However, the extent to which similar memory-based behaviors exist in seabirds is poorly understood. Our study investigated object recognition by Herring Gulls (Larus argentatus smithsonianus) on their breeding grounds, the site of a long-term monitoring project. When handling gulls and conducting field research, researchers wear standard bicycle helmets as a protective measure against physical aggression by nesting …
Integrating Clinical Cancer And Ptm Proteomics Data Identifies A Mechanism Of Ack1 Kinase Activation, Eranga R. Balasooriya, Deshan Madhusanka, Tania P. López-Palacios, Riley J. Eastmond, Dasun Jayatunge, Jake J. Owen, Jack S. Gashler, Christina M. Egbert, Chanaka Bulathsinghalage, Lu Liu, Stephen R. Piccolo, Joshua L. Andersen
Integrating Clinical Cancer And Ptm Proteomics Data Identifies A Mechanism Of Ack1 Kinase Activation, Eranga R. Balasooriya, Deshan Madhusanka, Tania P. López-Palacios, Riley J. Eastmond, Dasun Jayatunge, Jake J. Owen, Jack S. Gashler, Christina M. Egbert, Chanaka Bulathsinghalage, Lu Liu, Stephen R. Piccolo, Joshua L. Andersen
Faculty Publications
Beyond the most common oncogenes activated by mutation (mut-drivers), there likely exists a variety of low-frequency mut-drivers, each of which is a possible frontier for targeted therapy. To identify new and understudied mut-drivers, we developed a machine learning (ML) model that integrates curated clinical cancer data and posttranslational modification (PTM) proteomics databases. We applied the approach to 62,746 patient cancers spanning 84 cancer types and predicted 3,964 oncogenic mutations across 1,148 genes, many of which disrupt PTMs of known and unknown function. The list of putative mut-drivers includes established drivers and others with poorly understood roles in cancer. This ML …
Editorial: An Unexpected Event Related To The Aquatic Mammals Of Latin America, Daniel Gonzalez-Socoloske
Editorial: An Unexpected Event Related To The Aquatic Mammals Of Latin America, Daniel Gonzalez-Socoloske
Faculty Publications
No abstract provided.
Social And Biological Perspectives To Investigate And Address Illegal Shooting Of Raptors, Eve Thomason, Kenneth Wallen, Todd Katzner
Social And Biological Perspectives To Investigate And Address Illegal Shooting Of Raptors, Eve Thomason, Kenneth Wallen, Todd Katzner
Raptor Research Center Publications and Presentations
Humans have shot raptors for centuries. However, in many countries these actions have been illegal since the mid-twentieth century. Despite this history, there is not a comprehensive understanding of the characteristics of this activity, its frequency, and why it occurs. We used literature review and principles drawn from ecology, sociology, and criminology to understand this problem. First, we review literature on raptor shooting globally to explore documented motivations for shooting and we describe the history of raptor shooting in the United States of America (USA). Then, to illustrate the contemporary frequency and geographic breadth of the shooting of raptors, we …
Design, Fabrication, And Evaluation Of 3-D-Printed Cystotomy Spoons As A Retrieval Method In Dogs, Davina C. D'Angelo, Sam E. Stephens, Morten O. Jensen, Lauren R. Thomas
Design, Fabrication, And Evaluation Of 3-D-Printed Cystotomy Spoons As A Retrieval Method In Dogs, Davina C. D'Angelo, Sam E. Stephens, Morten O. Jensen, Lauren R. Thomas
Animal Science Faculty Publications and Presentations
OBJECTIVE
Current cystotomy methods often implement the use of off-label devices, resulting in urocystolith extraction difficulty and potentially leading to postoperative complications and discomfort for the patient. The objective of this study was to create 3 novel 3-D printed cystotomy spoons that offer a dedicated solution for removing urocystoliths from a patient's urinary bladder.
ANIMALS
Clinical use of the 3 novel 3-D printed cystotomy spoons were ultimately evaluated in 4 dogs and 1 cat that presented for urocystotlith removal at 3 different veterinary hospitals in northwest Arkansas.
METHODS
The novel cystotomy spoons were designed using SolidWorks, 3-D printed with a …
College Of Natural Sciences Newsletter, September - October 2023, College Of Natural Sciences
College Of Natural Sciences Newsletter, September - October 2023, College Of Natural Sciences
College of Natural Sciences Newsletters and Reports
Page 1 Dean's Message
Page 2 New Faculty an Staff for the Fall 2023 Semester
Page 3 Awards
Page 4 Student Ambassadors in CNS
Page 5 Meet our Jacks
Page 6-8 Events
Page 9-11 Media Coverage of CNS
Page 12-13 Spring 2023 Dean's List
Page 14 Open PRAIRIE Data
Farnesol Brain Transcriptomics In Cns Inflammatory Demyelination, William J. Doyle, Dana Walters, Xutong Shi, Kristina Hoffman, Krisztian Magori, Jean-Baptiste Roullet, Javier Ochoa-Repáraz
Farnesol Brain Transcriptomics In Cns Inflammatory Demyelination, William J. Doyle, Dana Walters, Xutong Shi, Kristina Hoffman, Krisztian Magori, Jean-Baptiste Roullet, Javier Ochoa-Repáraz
Biology Faculty Publications and Presentations
Background: Farnesol (FOL) prevents the onset of experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS).
Objective: We examined the transcriptomic profile of the brains of EAE mice treated with daily oral FOL using next-generation sequencing (RNA-seq).
Methods: Transcriptomics from whole brains of treated and untreated EAE mice at the peak of EAE was performed.
Results: EAE-induced mice, compared to naïve, healthy mice, overall showed increased expression in pathways for immune response, as well as an increased cytokine signaling pathway, with downregulation of cellular stress proteins. FOL downregulates pro-inflammatory pathways and attenuates the immune response in EAE. FOL …