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Articles 31291 - 31320 of 255945
Full-Text Articles in Life Sciences
Hjp 272, An Endothelin Receptor Antagonist, And Its Role In Cancer Cell Migration And Invasion, Nabeela Fatima Baig
Hjp 272, An Endothelin Receptor Antagonist, And Its Role In Cancer Cell Migration And Invasion, Nabeela Fatima Baig
Theses and Dissertations
Endothelins are a family of versatile peptides composed of 21 amino acids with three isoforms: ET-1, ET-2, and ET-3. As the most abundant of the three isoforms, ET-1 is involved in various biological processes, such as regulation of vascular tone, humoral homeostasis, and neural crest development. However, focus is now being directed towards investigating the functions of the Endothelin axis in the progression of different tumor types including ovarian, prostate, breast, lungs etc. HJP 272 is a novel ETAR antagonist and while our group has previously researched its effects on lung inflammation and preterm birth, this study marks the first …
Characterizing The Role Of Epigenetic Regulator Menin In Pediatric Neuroblastoma Growth Using Pre-Clinical Models, Rameswari Chilamakuri
Characterizing The Role Of Epigenetic Regulator Menin In Pediatric Neuroblastoma Growth Using Pre-Clinical Models, Rameswari Chilamakuri
Theses and Dissertations
Epigenetic regulators such as Menin and MLL1 drive cancer progression, metastasis, and relapse. MLL1 forms a COMPASS complex with its binding partners, including Menin, to function as an epigenetic enzyme H3K4 methyltransferase. H3K4 methyltransferases are known to promote cancer stem cells' (CSCs) self-renewal capacity and metastasis. CSCs are one of the major causes of tumor relapse and metastasis conditions, ultimately leading to poor overall patient survival. Neuroblastoma (NB) is an extracranial solid tumor that accounts for 8-10% of all pediatric cancers, and approximately 50% of patients display metastasis at the time of diagnosis. In this study, we hypothesized and used …
Developing A Novel Gold Nanoparticle-Based Colorimetric Assay For The Detection Of Cytomegalovirus (Cmv) In Pediatric-Derived Urine Specimens, Sonam Gupta
Graduate Thesis and Dissertation 2023-2024
Cytomegalovirus (CMV) is a member of the Herpesviridae family and is known to infect people of all ages. In most cases, CMV infection is asymptomatic, and the virus is cleared from the host without showing any significant symptoms. However, 1 out of 200 babies are born with congenital CMV infection, which affects multiple organs, including the brain, liver, spleen, lung, and inner ear. One long-term health problem in 1 out 5 babies born with congenital CMV infection is hearing loss. The progression of CMV-associated hearing loss in the first two years of life may lead to developmental delays in language, …
Beautiful Bees, Persistent Parasites: Rising Temperatures Leading To A Loss Of Our Arthropodic Furry Friends, Michael Eddy Harvey
Beautiful Bees, Persistent Parasites: Rising Temperatures Leading To A Loss Of Our Arthropodic Furry Friends, Michael Eddy Harvey
The Synapse: Intercollegiate science magazine
No abstract provided.
Driv·Ng Into The Future: The Rise Of Green Transportation In Oberlin, Sydney Rosensaft
Driv·Ng Into The Future: The Rise Of Green Transportation In Oberlin, Sydney Rosensaft
The Synapse: Intercollegiate science magazine
No abstract provided.
Great Artists Steal, Naci Konar-Steenberg
Great Artists Steal, Naci Konar-Steenberg
The Synapse: Intercollegiate science magazine
No abstract provided.
Melting Glaciers And New Diseases: The Mysteries Of The Microorganism, Martina Novajas
Melting Glaciers And New Diseases: The Mysteries Of The Microorganism, Martina Novajas
The Synapse: Intercollegiate science magazine
No abstract provided.
From Childhood Poverty To Academic Potential: Implications For Social Policy And Educational Equity, Amber Borofsky
From Childhood Poverty To Academic Potential: Implications For Social Policy And Educational Equity, Amber Borofsky
The Synapse: Intercollegiate science magazine
No abstract provided.
A Future Hope For Sickle Cell Disease: Historic Fda Approval Of First-Ever Sickle Cell Therapies, Abbie Patchen
A Future Hope For Sickle Cell Disease: Historic Fda Approval Of First-Ever Sickle Cell Therapies, Abbie Patchen
The Synapse: Intercollegiate science magazine
No abstract provided.
Rat Telekenetics: Hippocampal Cognition And Its Ability To Manipulate Virtual Reality, Will Gordon
Rat Telekenetics: Hippocampal Cognition And Its Ability To Manipulate Virtual Reality, Will Gordon
The Synapse: Intercollegiate science magazine
No abstract provided.
Biological Puppets: The Neuroscience Of Free Will And Determinism, Kate Martin
Biological Puppets: The Neuroscience Of Free Will And Determinism, Kate Martin
The Synapse: Intercollegiate science magazine
No abstract provided.
Unraveling Addiction: The Mechanisms Behind Alcohol Dependency And Withdrawal, Megan Carslo
Unraveling Addiction: The Mechanisms Behind Alcohol Dependency And Withdrawal, Megan Carslo
The Synapse: Intercollegiate science magazine
No abstract provided.
Revival And Resilience: Interview With Former Editor-In-Chief Gabe Hitchcock, Emma Rekate, Susan Robinson-Cloete
Revival And Resilience: Interview With Former Editor-In-Chief Gabe Hitchcock, Emma Rekate, Susan Robinson-Cloete
The Synapse: Intercollegiate science magazine
No abstract provided.
The Kids Are Not Okay: Increased Screen Time Correlated With Decreased Happiness, Sophie Qano
The Kids Are Not Okay: Increased Screen Time Correlated With Decreased Happiness, Sophie Qano
The Synapse: Intercollegiate science magazine
No abstract provided.
Uncovering Our Origins: How New Technologies Can Be Used To Interpret Our Ancient Past, Amelia Merithew
Uncovering Our Origins: How New Technologies Can Be Used To Interpret Our Ancient Past, Amelia Merithew
The Synapse: Intercollegiate science magazine
No abstract provided.
Quantifying The Ecological Effects Of Salix Fragilis On Riparian Habitat In Kittitas County, Washington, Landon Shaffer
Quantifying The Ecological Effects Of Salix Fragilis On Riparian Habitat In Kittitas County, Washington, Landon Shaffer
All Master's Theses
Invasive species threaten plant community structure and function globally. Riparian areas, the zone near streams where water influences vegetation, are especially sensitive to invasive species colonization, suffering large-scale shifts in community composition. Salix fragilis (crack willow) is a nonnative riparian species abundant in the lower elevation tributaries of central Washington. Some speculate whether this willow should be listed as invasive in Washington, despite a lack of regional supporting evidence. I studied riparian communities dominated by either S. fragilis or native species in the Kittitas Valley and measured biodiversity, quantified differences in solar attenuation, and compared leaf decomposition rates to learn …
University Biology Classrooms As Spaces For Anti-Racist Work: Instructor Motivations For Incorporating Race, Racism, And Racial Equity Content., Nicole L. Scheuermann, Candice Idlebird, Sayali Kukday, Vance J. Mccracken, Rachel E. Bradley, Heather E. Bergan-Roller
University Biology Classrooms As Spaces For Anti-Racist Work: Instructor Motivations For Incorporating Race, Racism, And Racial Equity Content., Nicole L. Scheuermann, Candice Idlebird, Sayali Kukday, Vance J. Mccracken, Rachel E. Bradley, Heather E. Bergan-Roller
Faculty Articles, Papers, and Other Scholarship
Science is often portrayed as a meritocratic endeavor, but university biology programs exhibit high rates of student attrition, particularly among students of Color, despite similar interest and aptitude for science, technology, engineering, and mathematics (STEM) as White students. Culturally relevant pedagogy is associated with student persistence in STEM. One way to practice culturally relevant pedagogy in biology courses is to engage students in discussions of race, racism, or racial equity. Guidance exists to help instructors incorporate race-related topics into the biology curriculum, but the reasoning behind the decision of whether to adopt this practice is not well characterized. Understanding instructors’ …
How Does Marijuana Affect Reproductive Health?, Miriam Blatner
How Does Marijuana Affect Reproductive Health?, Miriam Blatner
The Science Journal of the Lander College of Arts and Sciences
Marijuana use has become prevalent worldwide, especially amongst men and women of reproductive age. Marijuana acts on Cannabinoid receptors, which are a part of the Endocannabinoid system. CB1 and CB2 receptors are most found in humans. Activation of Cannabinoid receptors in males cause a reduction in healthy sperm parameters and inhibits the acrosomal reaction, and therefore minimizes fertility potential. Researchers have not yet discovered any significant interactions between marijuana and the female reproductive system. There has also been limited evidence displaying the effects that marijuana has on pregnancy and breastfeeding of infants. Nevertheless, physicians have recommended against marijuana use while …
Full Issue: Volume 17, Number 2, Spring 2024
Full Issue: Volume 17, Number 2, Spring 2024
The Science Journal of the Lander College of Arts and Sciences
Complete .pdf file of Volume 17, Number 2 of The Science Journal of the Lander College of Arts and Sciences. Published Spring 2024.
Targeting Vs. Modulating: How To Confront Variation In Cystic Fibrosis?, Yechiel Muller
Targeting Vs. Modulating: How To Confront Variation In Cystic Fibrosis?, Yechiel Muller
The Science Journal of the Lander College of Arts and Sciences
Cystic fibrosis is a genetic disease with over 2,000 reported mutation varieties. It affects a chloride channel called CFTR, which by the transmembrane transport of chlorine, maintains an apical membrane electrolyte equilibrium in luminal epithelial cells. Its malfunction results in cystic fibrosis which causes excess mucus in various organs and is associated with respiratory complications and salty sweat. Treatment of cystic fibrosis has primarily taken two approaches: a mutation-specific method, targeted at a particular mutation to restore its function, and a mutation-non-specific method, which modulates intracellular barriers to CFTR trafficking or cellular repression of mutant protein function. This paper presents …
Sibo And The Effectiveness Of Treatment Via Diet And Medication, Elizabeth C. Hersko
Sibo And The Effectiveness Of Treatment Via Diet And Medication, Elizabeth C. Hersko
The Science Journal of the Lander College of Arts and Sciences
This study delves into small intestinal bacterial overgrowth (SIBO), exploring its origins, diagnosis, and treatment methods. The research illuminates the complexities of SIBO, a condition characterized by an abnormal surge of bacteria in the small intestine. Factors contributing to SIBO include impaired motility, anatomical abnormalities, and digestive system dysfunctions. Diagnosing SIBO proves challenging due to its nonspecific symptoms which often overlap with other conditions like irritable bowel syndrome (IBS). Various diagnostic approaches, including lactulose breath testing, blood tests, stool analysis, and imaging, aim to identify SIBO and its underlying causes. Treatment involves dietary modifications—such as low FODMAP, biphasic, or fast …
Non-Surgical Treatment Options For Male-Pattern Baldness, Robert Schiffer
Non-Surgical Treatment Options For Male-Pattern Baldness, Robert Schiffer
The Science Journal of the Lander College of Arts and Sciences
Male pattern baldness affects nearly 50% of the world’s male population. It is associated with physiological conditions such as cardiovascular disease as well as psychological issues with self-image and self-esteem. Although surgical treatments exist, they are associated with risks and complications. Various non-surgical treatment modalities for male pattern baldness are available for patients. Topical and oral formulations of minoxidil, finasteride, and dutasteride can be used, in addition to low level light therapy (LLLT) and platelet rich plasma (PRP) therapy. As many treatment options exist, it may be challenging for patients to decide which to choose. Although there have been few …
What Is Aphthous Stomatitis? What Are The Possible Causes And Treatments?, Shirah Balakhane
What Is Aphthous Stomatitis? What Are The Possible Causes And Treatments?, Shirah Balakhane
The Science Journal of the Lander College of Arts and Sciences
The historical understanding of Recurrent Aphthous Stomatitis (RAS), also known as canker sores, has evolved. This paper aims to collect data that determines the underlying factors that can cause RAS and highlights treatments or preventive measures one should take. RAS is a common mucosal disease of the mouth that affects healthy people and presents atypically in immunocompromised people. Geographical, age, and gender-related factors can all affect the prevalence. RAS still has no known cause; however, several systemic, local, immunologic, genetic, dietary, allergy, and microbiological factors—including immunosuppressive medications and stress—have been suggested as potential culprits. Using topical and systemic medicines, the …
The Effects Of Electronic Cigarettes On The Oral Cavity, Batsheva Saposh
The Effects Of Electronic Cigarettes On The Oral Cavity, Batsheva Saposh
The Science Journal of the Lander College of Arts and Sciences
Electronic cigarettes, which became available for purchase in the United States in 2007, were initially touted as a harmless aid for smoking cessation. However, recent research into the impact of electronic cigarettes on the human body has shown potential deleterious effects. This paper aims to examine the effects electronic cigarette usage has on the oral cavity. The methods to compile research involved reading through many peer-reviewed articles to analyze the most current information on the topic. The findings indicate several potentially adverse effects on the oral cavity including oral cancer, periodontitis, dental caries, xerostomia, facial fractures, failed dental implants, and …