Life Sciences Commons^™

Analyzing Archive Transit Multibeam Data For Nodule Occurrences, Mark E. Mussett, David F. Naar, David W. Caress, Tracey A. Conrad, Alastair G. C. Graham, Max Kaufmann, Marcia Maia

Marine Science Faculty Publications

We show that analyzing archived and future multibeam backscatter and bathymetry data, in tandem with regional environmental parameters, can help to identify polymetallic nodule fields in the world’s oceans. Extensive archived multibeam transit data through remote areas of the world’s oceans are available for data mining. New multibeam data will be made available through the Seabed 2030 Project. Uniformity of along- and across-track backscatter, backscatter intensity, angular response, water depth, nearby ground-truth data, local slope, sedimentation rate, and seafloor age provide thresholds for discriminating areas that are permissive to nodule presence. A case study of this methodology is presented, using …

Identifying Youth Appeals In Alcohol Alternative Social Media Content Through Framing, Melina Oneal

West Chester University Master’s Theses

Proposed regulations for alcohol advertising prevent beverage companies from targeting people under the legal drinking age. However, similar regulations for alcohol alternative beverages are less explored, which could allow alcohol alternative products to create awareness for alcoholic beverages among youth. Alcohol alternatives beverages, including no-alcohol and low-alcohol products, are increasing in popularity and can function as compliments to alcoholic products to decrease the total alcohol volume consumed or as substitutes for alcoholic products. Framing theory can be operationalized through the Content Appealing to Youth Index, an index of content elements found in research literature to be appealing to youth, to …

Road Salt Intrusion Drives Changes In Wetland Plant Communities In Great Marsh, Pennsylvania, Benjamin Langey

West Chester University Master’s Theses

Freshwater salinization, especially the use of road salts for deicing, poses significant threats to freshwater wetlands. The Great Marsh in Elverson, Pennsylvania, is a unique and valuable freshwater ecosystem, and the largest contiguous freshwater wetland complex within the highly developed Philadelphia suburban landscape. Recently documented water quality and vegetative community degradation within the Marsh could be attributed to the Pennsylvania Turnpike, present along the Marsh’s southern boundary. Constructed in the 1950s, the Turnpike is a source of road salts and pathway for invasive species, namely the salt-tolerant Phragmites australis. To investigate the effects of road salt intrusion on emergent …

Investigating The Development Of Alcohol Tolerance In The Eskape Pathogens, Hannah Durkee

West Chester University Master’s Theses

Antiseptics and disinfectants are used globally to kill or inhibit the growth of bacteria to prevent infection. Considering the well-documented development of antibiotic resistance, the potential for evolved tolerance to alcohol-based antimicrobial agents raises concern. The ESKAPE bacterial pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) are a major cause of healthcare-associated mortality and present a threat to public health due to the progression of multi-drug resistance. We conducted an experiment to determine if the ESKAPE pathogens develop an increased tolerance to ethanol upon repeated exposure by selecting for survivors after a …

Pleated Plasma Membrane Complex In Spermatids Of The Western Siren, Siren Nettingi (Caudata: Sirenidae), S.E. Trauth

Journal of the Arkansas Academy of Science

I investigated the pleated plasma membrane complex of linear folds and biflagellar entities in developing spermatids of the Western Siren, Siren nettingi. My primary goal was to reveal the ultrastructural morphology of these distinctive cellular folds (usually 8 in number) as they support the flagellar formation of biflagellated sperm found in this salamander and in other members in the family Sirenidae. My results reveal that the biflagellar components (2 sets of axonemes, undulating membranes, and axial fibers), termed biflagellar complex, develop between folds or are attached onto these folds. The folds themselves are transitory and do not directly contribute to …

Spatiotemporal Distribution Of Mangrove Along The Egyptian Red Sea Coast And Analysis Of Hydrological Impact On Growth Patterns, H. Sewilam, B. T. Hassan, B. S. Khalil

Faculty Journal Articles

This study presents an in-depth spatiotemporal analysis of mangrove ecosystems along Egypt’s Red Sea coast, utilizing satellite imagery and GIS to examine changes from 2003 to 2022. We evaluate the effects of hydrological factors, specifically rainfall and runoff -presented by Stream Power Index-, on mangrove growth patterns. Results indicate a significant increase in mangrove areas, with a notable annual growth rate, despite a reduction in a specific region. This research highlights the integral role of catchment area runoff (R2 = 0.735, R = 0.857, P-value = 0.003 < 0.05, CV = 70.26%), rather than direct rainfall, in mangrove expansion, contributing to the understanding of mangrove resilience and informing sustainable coastal management strategies. The study bridges a significant research gap by mapping decadal mangrove changes, offering insights into the dynamics affecting these crucial ecosystems.

Kvx-053, A Protein Tyrosine Phosphatase 4a3 Inhibitor, Ameliorates Sars-Cov-2 Spike Protein Subunit 1 - Induced Acute Lung Injury In Mice, Pavel A. Solopov, Ruben Manuel Luciano Colunga Biancatelli, Tierney Day, Betsy Gregory, Elizabeth R. Sharlow, John S. Lazo, John D. Catravas

Bioelectrics Publications

The Acute Respiratory Distress Syndrome (ARDS), often preceded by acute lung injury (ALI), is characterized by the accumulation of inflammatory fluid in the lung alveoli, leaky alveolar epithelium and endothelium, and overexpression of pro-inflammatory cytokines. This progression from ALI to ARDS is a major contributor to the high mortality observed in COVID-19 patients. The Spike protein of SARS-CoV-2 binds to lung ACE2 and, in addition to facilitating viral cell entry, it plays an important role in the development of ALI and ARDS, especially in the later phases of COVID-19 as well as long COVID. Protein tyrosine phosphatase (PTP) 4A3 is …

Studying The Role Of Novel Carbon Nano Tubes As A Therapeutic Agent To Treat Triple Negative Breast Cancer (Tnbc) - An In Vitro And In Vivo Study, Kamal Asadipour, Narendra Banerjee, Jazmine Cuffee, Karrington Perry, Shennel Brown, Anasua Banerjee, Erik Armstrong, Stephen Beebe, Hirendra Banerjee

Bioelectrics Publications

Triple Negative Breast Cancer (TNBC) is a malignant cancer with a very high mortality rate around the world. African American(AA) women are 28% more likely to die from triple-negative breast cancer (TNBC) than white women with the same diagnosis. AA patients are also more likely to be diagnosed at a later stage of the disease and have the lowest survival rates for any stage of diagnosis; There are very few existing anti TNBC drugs with therapeutic efficacy hence newer anti TNBC drug design and investigation is needed. Carbon Nano Tubes(CNT) in recent years have shown effective anti-cancer properties in various …

Synergistic Effects Of Nanosecond Pulsed Plasma And Electric Field On Inactivation Of Pancreatic Cancer Cells In Vitro, Edwin A. Oshin, Zobia Minhas, Ruben M. L. Colunga Biancatelli, John D. Catravas, Richard Heller, Siqi Guo, Chunqi Jiang

Bioelectrics Publications

Nanosecond pulsed atmospheric pressure plasma jets (ns-APPJs) produce reactive plasma species, including charged particles and reactive oxygen and nitrogen species (RONS), which can induce oxidative stress in biological cells. Nanosecond pulsed electric field (nsPEF) has also been found to cause permeabilization of cell membranes and induce apoptosis or cell death. Combining the treatment of ns-APPJ and nsPEF may enhance the effectiveness of cancer cell inactivation with only moderate doses of both treatments. Employing ns-APPJ powered by 9 kV, 200 ns pulses at 2 kHz and 60-nsPEF of 50 kV/cm at 1 Hz, the synergistic effects on pancreatic cancer cells (Pan02) …

Wildflower Of The Year, White Turtlehead (Chelone Glabra), W. John Hayden

Biology Faculty Publications

White Turtlehead is a perennial herb rising from a rhizomatous rootstock.

The Multifunctional Catalytic Hemoglobin Fromamphitrite Ornata: Protocols On Isolation, Taxonomic Identification, Protein Extraction, Purification, And Characterization, Anna L. Husted, Lauren A. Presnar, R. Kevin Blackburn, Joseph L. Staton, Stephen A. Borgiani, Edward L. D'Antonio

Natural Sciences Faculty Publications

The multifunctional catalytic hemoglobin from the terebellid polychaete Amphitrite ornata, also named dehaloperoxidase (AoDHP), utilizes the typical oxygen transport function in addition to four observed activities involved in substrate oxidation. The multifunctional ability of AoDHP is presently a rare observation, and there exists a limitation for how novel dehaloperoxidases can be identified from macrobenthic infauna. In order to discover more infaunal DHP-bearing candidates, we have devised a facilitated method for an accurate taxonomic identification that places visual and molecular taxonomic approaches in parallel. Traditional visual taxonomic species identification by the non-specialist, at least for A. ornata or even for other …

The Effects Of A Brand-Specific, Hemp-Derived Cannabidiol Product On Physiological, Biochemical, And Psychometric Outcomes In Healthy Adults: A Double-Blind, Randomized Clinical Trial, Gianna F. Mastrofini, Bridget A. Mcfadden, Alexa J. Chandler Ph.D., Blaine S. Lints, Harry P. Cintineo, Nathaniel D. Rhoades, Caroline S. Vincenty, Sten O. Stray-Gundersen Ph.D., Abbi D. Lane, Shawn M. Arent Ph.D., Cscs*D, Fissn, Facsm, Fnak

Faculty Publications

Background: Cannabidiol (CBD) is a non-psychoactive phyto-cannabinoid derived from the Cannabis sativa plant. CBD exhibits various interactions at receptor sites, prompting the research of its potential anti-inflammatory, immunomodulatory, psychological, and pain-relieving effects. This study aimed to investigate the physiological, biochemical, and psychometric effects of a brand-specific, hemp-derived CBD product in healthy adults over a 12-week observation period. Methods: 54 healthy males and females (age = 25 ± 7y; BMI = 24.82 ± 3.25 kg/m2) recruited from a large Southeastern University completed the study. Participants arrived at the laboratory after > 8 h of fasting, and > 48 h without alcohol consumption and …

Common Questions And Misconceptions About Caffeine Supplementation: What Does The Scientific Evidence Really Show?, Jose Antonio, Daniel E. Newmire, Jeffrey R. Stout, Brandi Antonio, Maureen Gibbons, Lonnie M. Lowery, Joseph Harper, Darryn Willoughby, Cassandra Evans, Dawn Anderson, Erica Goldstein, Jose Rojas, Matías Monsalves-Álvarez, Scott C. Forbes, Jose Gomez Lopez, Tim Ziegenfuss, Blake D. Moulding, Darren Candow, Michael Sagner, Shawn M. Arent Ph.D., Cscs*D, Fissn, Facsm, Fnak

Faculty Publications

Caffeine is a popular ergogenic aid that has a plethora of evidence highlighting its positive effects. A Google Scholar search using the keywords “caffeine” and “exercise” yields over 200,000 results, emphasizing the extensive research on this topic. However, despite the vast amount of available data, it is intriguing that uncertainties persist regarding the effectiveness and safety of caffeine. These include but are not limited to: 1. Does caffeine dehydrate you at rest? 2. Does caffeine dehydrate you during exercise? 3. Does caffeine promote the loss of body fat? 4. Does habitual caffeine consumption influence the performance response to acute caffeine …

Aggravated Ulcerative Colitis Via Circnlgn-Mediated Suppression Of Nuclear Actin Polymerization., William W Du, Chi Zhou, Hui Yang, Shuoyang Wen, Yu Chen, Eric X Chen, Xiuwei H. Yang, Feiya Li, Kevin Y Du, Hui Yuan, Ting Ye, Javeria Qadir, Burton B Yang

Pharmacology and Nutritional Sciences Faculty Publications

Colitis is a chronic bowel disease characterized by damage to the lining of the large intestine, with its precise underlying causes remaining incompletely understood. In this study, we provide evidence that circular RNA circNlgn plays a pivotal role in promoting the development of colitis. Colitis patients produce significant higher levels of circNlgn. Transgenic mice expressing circNlgn exhibit heightened susceptibility to colitis development and progression, primarily attributed to the presence of the protein isoform Nlgn173 encoded by circNlgn. Nlgn173 undergoes translocation into cell nuclei, where it interacts with actin, impeding the binding of actin-related protein 2 and 3 (Arp2/3) complex to …

Multi-Strain Probiotic Improves Subjective Sleep Quality With No Impact On Body Composition, Hemodynamics, And Physical Activity, Chad Kerksick, Jessca Moon, Kylie Walden, Anthony Hagele, L. E. Allen, Connor J. Gaige, Joesi M. Krieger, Ralf Jäger, Marco Pane, Petey Mumford

Faculty Scholarship

The objective of the study was to examine the impact of a multi-strain probiotic (MSP) on sleep, physical activity, and body composition changes. We used a randomised, double-blind, placebo-controlled approach with 70 healthy men and women (31.0 ± 9.5 years, 173.0 ± 10.4 cm, 73.9 ± 13.8 kg, 24.6 ± 3.5 kg/m2) supplemented daily with MSP (4 × 109 live cells Limosilactobacillus fermentum LF16, Lacticaseibacillus rhamnosus LR06, Lactiplantibacillus plantarum LP01, and Bifidobacterium longum 04; Probiotical S.p.A., Novara, Italy) or placebo (PLA). In response to supplementation (after 0, 2, 4, and 6 weeks of supplementation) and 3 weeks after stopping supplementation, …

The Standing Of Anger: Insights From The Debate(S) On Constructed Emotion, Andrew Holzer

CMC Senior Theses

In her book, Anger and Forgiveness: Resentment, Generosity, Justice, Martha Nussbaum argues that anger is inherently flawed because it fundamentally contains the desire for payback. To support her argument, she posits specific metaphysical claims about the nature of emotions like anger. This thesis is an extended critique of her metaphysical foundation from the perspective of empirical research in the neuroscience of emotion. The first reason to dispute this picture is descriptive; this view of anger is based on an outdated version of cognitive appraisal theory, which sees emotions as triggered directly by static moments of cognitive appraisal. The second …

Atg11 And Atg9 Interaction In Selective Autophagy, Chimi Dolker Sherpa

Master's Theses and Doctoral Dissertations

Selective autophagy, induced by cellular stresses, degrades/recycles a specific cargo. Ithelps prevent diseases like Parkinson’s, Huntington's, cancer, and bacterial infections. It involves the formation of an autophagosome, a double-membrane vesicle that takes the cargo to the vacuole/lysosome for degradation. Atg11, the central organizer of selective autophagy, acts as a scaffold protein, interacting with Atg9, Atg1 and other Atg proteins. Our research focuses on finding mutations in Atg11 that specifically disrupt its interaction with Atg9 without affecting its dimerization or interaction with Atg1. We targeted residues 455-535 of Atg11 as a putative Atg9 interaction site, performing mutagenesis on four key residues …

Population Screening For High-Risk Patient Identification Partnership With Care-Comprehensive Assessment, Risk, And Education., Ora K Gordon, Brad Bott, Nanor Parseghian, Kimberly K Childers, Sandra Brown

Articles, Abstracts, and Reports

No abstract provided.

แหล่งที่อยู่และแบบจำลองการกระจายของจิ้งเหลนภูเขาสกุล Sphenomorphus Fitzinger, 1843 ในอุทยานแห่งชาติดอยภูคา จังหวัดน่าน, ธนกฤต สัมพันธ์แพ

Chulalongkorn University Theses and Dissertations (Chula ETD)

จิ้งเหลนภูเขาในสกุล Sphenomorphus Fitzinger, 1829 เป็นจิ้งเหลนที่มีความหลากหลายทางชนิดและมีพฤติกรรมตามธรรมชาติที่มักหลบซ่อนตัว จึงทำให้จิ้งเหลนสกุลนี้หลายชนิดยังขาดข้อมูลแหล่งที่อยู่และข้อมูลทางภูมิศาสตร์ โดยเฉพาะชนิดที่อาศัยอยู่ในพื้นที่ภูเขาสูงในทางภาคเหนือ นอกจากในอุทยานแห่งชาติดอยภูคา จังหวัดน่าน พบจิ้งเหลนภูเขา 3 ชนิด ได้แก่ จิ้งเหลนภูเขาเกล็ดเรียบ จิ้งเหลนภูเขาอินเดีย และจิ้งเหลนภูเขาแกรนดิสัน แต่อย่างไรก็ตามข้อมูลแหล่งที่อยู่และการศึกษาขอบเขตการกระจายของจิ้งเหลนเหล่านี้ยังไม่ชัดเจน ดังนั้นงานวิจัยนี้จึงมีวัตถุประสงค์เพื่อศึกษาแหล่งที่อยู่ของจิ้งเหลนภูเขาในอุทยานแห่งชาติดอยภูคาและประเมินภูมิศาสตร์การกระจายโดยใช้แบบจำลองการกระจายของชนิด (species distribution modeling; SDM) การสำรวจในภาคสนามใช้วิธีสำรวจแบบพบเห็นตัวร่วมกับการกำหนดเส้นสำรวจ ข้อมูลแหล่งที่อยู่และข้อมูลปัจจัยสภาพแวดล้อมนำมาวิเคราะห์ด้วยการทดสอบไคสแควร์และการวิเคราะห์องค์ประกอบหลัก จากนั้นนำข้อมูลพิกัด GPS จากการสำรวจภาคสนาม ข้อมูลตัวอย่างอ้างอิงในพิพิธภัณฑ์ธรรมชาติวิทยา ข้อมูลจาก GBIF และการลาดตระเวนเชิงคุณภาพ มาทำการวิเคราะห์ด้วยแบบจำลองการกระจายของชนิดร่วมกับปัจจัยสภาพอากาศจาก WorldClim ทั้ง 15 ปัจจัย และปัจจัยเชิงพื้นที่ 2 ปัจจัย ได้แก่ ความสูงจากระดับน้ำทะเล และ ความลาดชัน จาก OpenDataSoft ด้วยโปรแกรม MaxEnt ผลการศึกษาแหล่งที่อยู่พบว่า จิ้งเหลนภูเขาเกล็ดเรียบอาศัยอยู่ในป่าเบญจพรรณ จิ้งเหลนภูเขาอินเดียอาศัยอยู่ในป่าสนและป่าดิบเขา และ จิ้งเหลนภูเขาแกรนดิสันอาศัยอยู่ในป่าดิบเขาเท่านั้น ผลการศึกษาแหล่งที่อยู่ย่อยพบว่าก้อนหิน เป็นองค์ประกอบที่พบได้มากที่สุดในพื้นที่อาศัยของจิ้งเหลนภูเขาเกล็ดเรียบ และกองใบไม้เป็นองค์ประกอบที่พบได้มากที่สุดในพื้นที่อาศัยของจิ้งเหลนภูเขาอินเดียและจิ้งเหลนภูเขาแกรนดิสัน การวิเคราะห์องค์ประกอบหลักตัวแปรสิ่งแวดล้อมที่มีอิทธิพลต่อการเลือกใช้แหล่งที่อยู่ย่อยของจิ้งเหลนภูเขาเกล็ดเรียบ จิ้งเหลนภูเขาอินเดีย และ จิ้งเหลนภูเขาแกรนดิสัน คือ อุณหภูมิอากาศ ระดับความสูงจากน้ำทะเลและความชื้นสัมพัทธ์ในอากาศ ตามลำดับ ผลการศึกษาแบบจำลองการกระจายของชนิด พบว่าปัจจัยสำคัญสำหรับการทำนายแหล่งที่อยู่ของจิ้งเหลนภูเขาเกล็ดเรียบและจิ้งเหลนภูเขาอินเดียคือ อุณหภูมิช่วงรายวันเฉลี่ย และ ปัจจัยสำคัญสำหรับการทำนายแหล่งที่อยู่ของจิ้งเหลนภูเขาแกรนดิสันคือปริมาณน้ำฝนตามฤดูกาล และยังพบว่าแนวโน้มการกระจายของจิ้งเหลนภูเขาเกล็ดเรียบอยู่บริเวณพื้นที่ราบเชิงเขา จิ้งเหลนภูเขาอินเดียอยู่บริเวณตามแนวเทือกเขาและ จิ้งเหลนภูเขาแกรนดิสันอยู่บริเวณยอดเขาสูงของอุทยานแห่งชาติดอยภูคาเท่านั้น ผลของการศึกษาที่ได้สามารถนำมาใช้ในการวางแผนการอนุรักษ์และยังแสดงให้เห็นถึงการประยุกต์ใช้แบบจำลองถิ่นอาศัยในการทำนายแผนที่การกระจายทางภูมิศาสตร์ของสัตว์เลื้อยคลาน

Fusion Et Validation De Modèles Musculosquelettiques De La Colonne Lombaire Pour La Prévention Et La Réadaptation Des Travailleurs, Christian Larivière, Farshid Ghezelbash, Amir Eskandari, Denis Gagnon, Hakim Mecheri, Navid Arjmand, Aboulfazl Shirazi-Adl

Rapports de recherche scientifique

Les charges imposées sur la colonne vertébrale lombaire constituent un facteur de risque important pour les maux de dos. Connaître la distribution de ces forces internes lors d’activités de travail est nécessaire autant en prévention qu’en réadaptation des travailleurs. La modélisation musculosquelettique (MS) de la colonne vertébrale est la seule approche non invasive permettant d’estimer les charges sur les structures internes de la colonne.

Deux modèles ont été développés au Québec, soient un modèle par éléments finis (MEF) guidé par le mouvement et un autre guidé par des mesures électromyographiques (EMG) d’activation musculaire (modèle MEMG). Ces modèles sont donc sensibles …

Exposition Professionnelle Des Femmes Aux Substances Chimiques : Amélioration D’Une Matrice Emploi Exposition Existante Pour Fournir Des Estimations Spécifiques Au Sexe : Rapport Abrégé, Vikki Ho, Chelsea Almadin, France Labrèche, Mark Goldberg, Marie-Élise Parent, Jack Siemiatycki, Jérôme Lavoué

Rapports de recherche scientifique

Il est reconnu que les femmes et les hommes ont des profils professionnels différents qui peuvent donc se traduire par des risques de maladie professionnelle différents. Pourtant, la plupart de nos connaissances actuelles sur les maladies professionnelles découlent d'études menées auprès des hommes. Or, les femmes représentent actuellement 48 % de la population active au Québec. La santé des femmes dans l’environnement de travail demeure un domaine sous-étudié et nous sommes particulièrement freinés par le manque de compréhension de l'impact du genre sur l'exposition en milieu de travail. Il a été démontré que l'attribution des tâches et les conditions de …

Occupational Exposures Of Women To Chemical Substances: Improvement Of An Existing Job Exposure Matrix To Provide Sex-Specific Estimations Of Exposure, Vikki Ho, Chelsea Almadin, France Labrèche, Mark Goldberg, Marie-Élise Parent, Jack Siemiatycki, Jérôme Lavoué

Rapports de recherche scientifique

Il est reconnu que les femmes et les hommes ont des profils professionnels différents qui peuvent donc se traduire par des risques de maladie professionnelle différents. Pourtant, la plupart de nos connaissances actuelles sur les maladies professionnelles découlent d'études menées auprès des hommes. Or, les femmes représentent actuellement 48 % de la population active au Québec. La santé des femmes dans l’environnement de travail demeure un domaine sous-étudié et nous sommes particulièrement freinés par le manque de compréhension de l'impact du genre sur l'exposition en milieu de travail. Il a été démontré que l'attribution des tâches et les conditions de …

Whatever Happened To The Snapdragon Family?, W. John Hayden

Biology Faculty Publications

The short answer is DNA sequencing and phylogenetic systematics.

Exploration Of Potential Broad-Spectrum Antiviral Targets In The Enterovirus Replication Element: Identification Of Six Distinct 5' Cloverleaves, Morgan G. Daniels, Meagan E. Werner, Rockwell T. Li, Steven M. Pascal

Chemistry & Biochemistry Faculty Publications

Enterovirus genomic replication initiates at a predicted RNA cloverleaf (5′CL) at the 5′ end of the RNA genome. The 5′CL contains one stem (SA) and three stem-loops (SLB, SLC, SLD). Here, we present an analysis of 5′CL conservation and divergence for 209 human health-related serotypes from the enterovirus genus, including enterovirus and rhinovirus species. Phylogenetic analysis indicates six distinct 5′CL serotypes that only partially correlate with the species definition. Additional findings include that 5′CL sequence conservation is higher between the EV species than between the RV species, the 5′CL of EVA and EVB are nearly identical, and RVC has the …

Multiple Variables Influence The Finely Calibrated Antioxidant Defenses Of Clostridioides Difficile, Erin B. Purcell

Chemistry & Biochemistry Faculty Publications

The obligate anaerobe Clostridioides difficile encodes multiple reductases to detoxify molecular oxygen and reactive oxygen species. Caulat and colleagues have characterized the activity and regulation of four such reductases (L. C. Caulat, A. Lotoux, M. C. Martins, N. Kint, et al., mBio 15:e01591-24, 2024, https://doi.org/10.1128/mbio.01591-24). Each proved critical for clostridial survival in a different range of oxygen concentrations; together, they ameliorate a broad range of oxidative stress levels. Moreover, two previously uncharacterized regulators were found to control reductase gene expression in response to oxidative stress. The genetic repressor Rex and the reductase FdpF are both sensitive to the NAP …

The Splice Index As A Prognostic Biomarker Of Strength And Function In Myotonic Dystrophy Type 1, Marina Provenzano

Theses and Dissertations

Myotonic dystrophy type 1 (DM1) is a slowly progressive, multisystem disorder caused by a CTG repeat expansion in the DMPK 3’UTR that leads to global dysregulation of alternative splicing. The resulting decline in physical function is slow, and no reliable biomarkers exist for predicting disease progression; however, an RNA mis-splicing biomarker associated with weakness may have utility in predicting functional outcomes. Here we validate the Splice Index (SI) as a potential biomarker of DM1-associated strength and function. Muscle biopsies of the tibialis anterior were collected from DM1-affected individuals at baseline (n = 46) and 3-months (n = 34), along with …

Spatiotemporal Patterns For Agroforestry Tree Crops In The U.S. Corn Belt For Usda Census Of Agriculture Periods 2012–2022, Andria Caruthers, Justin Dijak, Robin M. Rotman

Faculty Publications

Within the U.S., there is a growing need to integrate environmentally friendly practices into conventional agriculture. Agroforestry enhances environmental and resource stewardship in agricultural landscapes while offering potential economic benefits to farmers. Despite rising interest, limited information on its application in the U.S. hinders development efforts. A spatiotemporal analysis of current farm operations can provide crucial insights. This study examined patterns of agroforestry and tree crop adoption in the U.S. Corn Belt using USDA Census data (2012, 2017, and 2022) and spatial tools (Global Moran’s I, Local Moran’s I, and Moran scatterplots). The tree crops included in the analysis were …

Antenatal Depression And Its Associated Factors: Findings From Kuwait Birth Cohort Study, Reem Al-Sabah, Abdullah Al-Taiar, Ali H. Ziyab, Saeed Akhtar, Majeda S. Hammoud

Community & Environmental Health Faculty Publications

Background: Pregnant and postpartum women are at high risk of depression due to hormonal and biological changes. Antenatal depression is understudied compared to postpartum depression and its predictors remain highly controversial.

Aim: To estimate the prevalence of depressive symptoms during pregnancy and investigate factors associated with this condition including vitamin D, folate and Vitamin B₁₂ among participants in the Kuwait Birth Study.

Methods: Data collection occurred as part of the Kuwait Birth Cohort Study in which pregnant women were recruited in the second and third trimester during antenatal care visits. Data on antenatal depression were collected using the Edinburgh …

How Financial Status Affects Food Decisions In Households Of Marin City, Joe Blakely

Global Public Health | Senior Theses

This research addresses disparities in food decision-making among households in Marin City by examining their food spending habits after covering essential bills. Understanding how these households allocate resources for food is crucial for developing targeted interventions to improve food security and health outcomes. Utilizing qualitative methods, semi-structured interviews, this study explores the spending patterns and decision-making processes related to food expenditures among households in Marin City. The sampling method ensures consideration of different economic levels and grocery strategies. Recruitment involves collaboration with community organizations and social service agencies such as Marin City Community Center. The study focuses on residents of …

Phylogenetic Relationships Of A North American Radiation Of Clematis (Ranunculaceae), Jesse Harris, Thomas H. Murphy, Erin A. Manzitto-Tripp, Nicolás Medina, Zach Irick, L. Dwayne Estes, Stacey D. Smith

Aliso: A Journal of Systematic and Floristic Botany

Clematis L. is one of many plant genera that contributes prominently to the species richness and endemism of the southeastern United States. Here we examined phylogenetic relationships among species in Clematis sect. Viorna, commonly known as leatherflowers, which are distributed primarily in the southeastern United States. We used data from restriction site-associated ddRADseq to reconstruct a best estimate phylogeny of this group. Our analyses revealed that the North American members of sect. Viorna form a well-supported clade, and several of the traditionally recognized infrasectional taxa were resolved as monophyletic. Although characters employed in classification including habit and inflorescence position …