Life Sciences Commons^™

Improve Governance System Of National Parks, Build The World‘S Largest National Park System With High Quality, Baorong Huang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Improving the governance system of national parks is an inevitable requirement for China’s high-quality construction of the world’s largest national park system. This study analyzes the main challenges and problems faced by China’s national park governance based on long-term investigation on national parks and national park system pilot areas. Under the overall logic of modernization of China’s national governance system and governance capabilities, drawing on international experiences in sound governance of regional and watershed public goods and national parks, this study proposes a theoretical framework for establishing a “four in one” national park governance system in China, including a comprehensive …

Problems And Suggestions Of Building Scientific Decision-Making And Advisory Mechanism Of National Parks—Governance-Based Perspective, Yu Wei, Duowei Cheng, Yi Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

National parks are multi-factor, multi-functional and multi-dimensional complexes, which makes them difficult to follow the traditional administration and management modes, and need to explore the construction of a modernized governance system. An important step in enhancing the effectiveness of governance is to establish a reasonable, and efficient scientific decision-making and consultation mechanism. China has made remarkable progress in scientific decision-making and consultation in national parks. However, there are still some problems with the national parks’ decision-making process and effectiveness due to vague definition of authority and responsibility, dependence on departmentalized management paths, and inadequate upward and downward transmission of information …

Regime Of National Park Group Based On Protected Area System In Tibetan Plateau, Dong Chen, Yafei Wang, Dengsheng Wu, Jie Fan

Bulletin of Chinese Academy of Sciences (Chinese Version)

China’s national park reform has entered a new stage of promoting reform based on the protected area system. The national park team of the second comprehensive scientific investigation and research on the Tibetan Plateau (TP) took the lead in putting forward the construction plan of the TP protected area, which is dominated by national park in area and function. The TP national park group, including “small group” which refer to national park, and “large group” which refer to different protected areas, innovates the long-term mechanism for the construction of national ecological security barriers on TP. The national park group requires …

Experience And Enlightenment Of Eu Natura 2000 Protected Area Network, Ling Tang, Baorong Huang, Tong Jin, Xuetian Hu

Bulletin of Chinese Academy of Sciences (Chinese Version)

The EU Natura 2000 protected area network, covering nearly 19% of the land and 10% of the sea in the EU, has played an important role in protecting biodiversity and enhancing regional socio-economic well-being, and is regarded as the most successful protected area network in the world. Its successful experience is mainly reflected in five aspects. (1) The adoption of regional biodiversity conservation legislation and the promotion of compliance with the law by member countries to promote the construction of the protected area network. (2) The establishment of a decision-making and implementation mechanism that combines the EU resolution process and …

Panorama Of Human Embryo-Derived Cells In Biomedicine And Progress In Their Research And Regulation, Jianchao Gao, Yaojin Peng, Wei Wei, Shuang Lu, Chenyan Gao

Bulletin of Chinese Academy of Sciences (Chinese Version)

Since the establishment of the first human diploid cell line derived from aborted fetal tissue in the 1960s, human embryoderived cells have been widely used in biomedical field and significantly contributes to improving human health. In recent years, human pluripotent stem cells, including human embryonic stem cells (hESCs), have shown great therapeutic potential in regenerative medicine, and thus received great attention from governments and the public. However, due to various factors such as history, culture, religious beliefs, ethics and morality, research and application involving human embryo-derived cells have been controversial worldwide. This study explores the history and progress of human …

The Fuxi Farm: Practice Exploration And Reflection On Integrated Innovation Of Smart Agriculture Technology, Yucheng Zhang, Xiaobo Zhang, Shuqin Gao, Congcong Zheng, Jingyao Zhang, Ya Wen, Lujun Li, Zhuo Wang, Tie Li, Honglong Zhao

Bulletin of Chinese Academy of Sciences (Chinese Version)

Smart agriculture plays a pivotal role in enhancing food security by optimizing resource use and improving crop yields through the application of AI technologies. The establishment of smart farms is critical to rapidly integrating AI into agricultural production, offering platforms for both the deployment and testing of AI solutions and equipment. This paper examines the development of smart farms, with a focus on practices from developed countries, and assesses the current status of smart farming in China. We then focus on exploring the content, pathways, and practices for constructing a smart agricultural production system in China through the establishment of …

Accelerate Innovation Of Forage Intelligent Breeding Technology: Reflection And Suggestions, Haichun Jing, Weijuan Hu, Jingbo Jin, Jingyu Zhang, Yao Zhou, Yue Gong, Gang Yao, Lei Wang, Kang Chong

Bulletin of Chinese Academy of Sciences (Chinese Version)

The world is facing unprecedented changes today, with continuous population growth intensifying the pressure on food demand. The shift towards diversified dietary structures has increased the demand for feed grains, while climate change further threatens China’s food security by affecting agricultural productivity and carbon sequestration economy. At present, China has entered a new era of food supply and feed. As the food supply for animals, forage is the core component of feed, and its industrial development has profound strategic significance for ensuring national food security. This study analyzes the current situation of China’s forage seed industry, summarizes the cutting-edge achievements …

Rapid Soil Detection Technology Aids In Assessing Soil Nutrients In China, Wei Wu, Xiaoyong Liao, Xiaopeng Li, Yuntao Wu, Huixian Lu, Yucheng Zhang, Jiabao Zhang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Soil quality is the core issue for ensuring China’s food security, and soil health is the top priority of soil quality. Comprehensive, rapid and accurate acquisition of soil background data is the prerequisite for achieving homogeneous soil management and formulating balanced fertilization strategies, which will play a key role in improving non-point source pollution caused by unreasonable fertilization and achieving balanced grain yield increase. This study reviews rapid soil testing methods both domestically and internationally. Based on previous research, it proposes a technical approach to rapidly detect soil nutrient concentrations by calculating the gamma quanta released during the decay of …

Hillside Agricultural Machinery And Agricultural Intelligence Driven By New Technologies, Hong Qiao, Yanfeng Lyu, Enhao Zheng

Bulletin of Chinese Academy of Sciences (Chinese Version)

Hilly and mountainous areas play a crucial role in China’s agricultural production. However, the low level of comprehensive mechanization for crop cultivation, planting, and harvesting in these regions severely hampers the modernization of agriculture. The complex terrain and diverse cropping patterns in hilly areas necessitate the development of specialized agricultural machinery and robots tailored to these unique landscapes. To advance this process, the Chinese government has introduced a series of policies in recent years to support the research and development of agricultural machinery for hilly regions, providing strong backing for the advancement of agricultural technology in these areas. Against this …

Artificial Intelligence Innovation For Smart Plant Factory To Diversify Its Big Food Production Functions, Huaqin Gong, Haichun Jing, Xin Tan, Xianhui Wang, Yucheng Zhang, Rongcheng Lin, Mingyu Yang, Shuang Lin, Hualing Xie, Yanping Yang, Shitang Ye, Peng Li, Tingyun Kuang

Bulletin of Chinese Academy of Sciences (Chinese Version)

China’s food security is facing more and more severe and complex challenges, such as tight balance between food demand and supply, the upgrading of consumption structure, and resource constraints. The plant factory is an advanced scenario in agricultural production, a diversified food production system that gets rid of the constraints of “ask for food from the mother nature” and respond to disasters and wars, and is oriented to space. Nevertheless, the high cost greatly limits the application and development of plant factories. The rapid development of artificial intelligence will bring new opportunities for the innovative development and expansion of plant …

Molecular, Metabolic, And Subcellular Mapping Of The Tumor Immune Microenvironment Via 3d Targeted And Non-Targeted Multiplex Multi-Omics Analyses, Sammy Ferri-Borgogno, Jared K Burks, Erin H Seeley, Trevor D Mckee, Danielle L Stolley, Javier A Gomez, Shamini Ayyadhury, Barrett C Lawson, Melinda S Yates, Michael J Birrer, Karen H Lu, Samuel C Mok

Faculty, Staff and Student Publications

Most platforms used for the molecular reconstruction of the tumor-immune microenvironment (TIME) of a solid tumor fail to explore the spatial context of the three-dimensional (3D) space of the tumor at a single-cell resolution, and thus lack information about cell-cell or cell-extracellular matrix (ECM) interactions. To address this issue, a pipeline which integrated multiplex spatially resolved multi-omics platforms was developed to identify crosstalk signaling networks among various cell types and the ECM in the 3D TIME of two FFPE (formalin-fixed paraffin embedded) gynecologic tumor samples. These platforms include non-targeted mass spectrometry imaging (glycans, metabolites, and peptides) and Stereo-seq (spatial transcriptomics) …

Circulating Microrna Biomarkers Of Thiazide Response In Hypertension, Lakshmi Manasa S Chekka, Marwa Tantawy, Taimour Langaee, Danxin Wang, Rolf Renne, John G Gums, Rhonda M Cooper-Dehoff, Julie A Johnson

Faculty, Staff and Student Publications

Background: Thiazide diuretics are the second most frequently prescribed class of antihypertensives, but up to 50% of patients with hypertension have minimal antihypertensive response to thiazides. We explored circulating microRNAs (miRNAs) in search of predictive biomarkers of thiazide response.

Methods and results: We profiled 754 miRNAs in baseline plasma samples of 36 hypertensive European American adults treated with hydrochlorothiazide, categorized into responders (n=18) and nonresponders (n=18) on the basis of diastolic blood pressure response to hydrochlorothiazide. miRNAs with ≥2.5-fold differential expression between responders and nonresponders were considered for validation in 3 cohorts (n=50 each): hydrochlorothiazide-treated European Americans, chlorthalidone-treated European Americans, …

Multivalent Cytomegalovirus Glycoprotein B Nucleoside Modified Mrna Vaccines Did Not Demonstrate A Greater Antibody Breadth, Hsuan-Yuan Wang, Leike Li, Cody S Nelson, Richard Barfield, Sarah Valencia, Hiromi Muramatsu, Norbert Pardi, Zhiqiang An, Drew Weissman, Sallie R Permar

Faculty, Staff and Student Publications

Human cytomegalovirus (HCMV) remains the most common congenital infection and infectious complication in immunocompromised patients. The most successful HCMV vaccine to date, an HCMV glycoprotein B (gB) subunit vaccine adjuvanted with MF59, achieved 50% efficacy against primary HCMV infection. A previous study demonstrated that gB/MF59 vaccinees were less frequently infected with HCMV gB genotype strains most similar to the vaccine strain than strains encoding genetically distinct gB genotypes, suggesting strain-specific immunity accounted for the limited efficacy. To determine whether vaccination with multiple HCMV gB genotypes could increase the breadth of anti-HCMV gB humoral and cellular responses, we immunized 18 female …

An Extended Bayesian Semi-Mechanistic Dose-Finding Design For Phase I Oncology Trials Using Pharmacokinetic And Pharmacodynamic Information, Chao Yang, Yisheng Li

Faculty, Staff and Student Publications

We propose a model-based, semi-mechanistic dose-finding (SDF) design for phase I oncology trials that incorporates pharmacokinetic/pharmacodynamic (PK/PD) information when modeling the dose-toxicity relationship. This design is motivated by a phase Ib/II clinical trial of anti-CD20/CD3 T cell therapy in non-Hodgkin lymphoma patients; it extends a recently proposed SDF model framework by incorporating measurements of a PD biomarker relevant to the primary dose-limiting toxicity (DLT). We propose joint Bayesian modeling of the PK, PD, and DLT outcomes. Our extensive simulation studies show that on average the proposed design outperforms some common phase I trial designs, including modified toxicity probability interval (mTPI) …

The Pathogenicity Of Vancomycin-Resistant Enterococcus Faecalis To Colon Cancer Cells, Fangyu Wang, Wei Yu

Faculty, Staff and Student Publications

BACKGROUND: The aim of this study was to investigate the pathogenicity of vancomycin-resistant Enterococcus faecalis (VREs) to human colon cells in vitro.

METHODS: Three E. faecalis isolates (2 VREs and E. faecalis ATCC 29212) were cocultured with NCM460, HT-29 and HCT116 cells. Changes in cell morphology and bacterial adhesion were assessed at different time points. Interleukin-8 (IL-8) and vascular endothelial growth factor A (VEGFA) expression were measured via RT-qPCR and enzyme-linked immunosorbent assay (ELISA), respectively. Cell migration and human umbilical vein endothelial cells (HUVECs) tube formation assays were used for angiogenesis studies. The activity of PI3K/AKT/mTOR signaling pathway was measured …

Commercially Available Products In Increase Soil Water-Holding Capacity, Shital Poudyal, Jake Powell, Rowe Zwahlen, Grant Cardon

All Current Publications

Although adding organic matter is traditionally the most effective way to enhance soil water-holding capacity, several commercial products in the market also have the potential to increase soil water-holding capacity. In this fact sheet, we discuss the properties and characteristics of those commercially available products and recommended application rates. We also explore some limitations of using these products.

Herbaceous Tropical Legume Integration Into Small-Holder Crop-Livestock Systems In Eastern Indonesia: Results Of 10-Years Of Multi-Disciplinary Systems Research, L. W. Bell, D. Mayberry, K. Cox, S. Traill, J. Nulik, E. J. Hosang, D. Kana Hau

IGC Proceedings (1977-2023)

Integration a forage legume into crop-livestock systems of Eastern Indonesia was tested to establish the capacity to improve nitrogen supply and yields of staple cereal crops (maize and rice) and allow for intensification of beef production to ultimately increase farm income and alleviate rural poverty in the region. Species evaluation sites across a diversity of environments showed Clitoria ternatea (butterfly pea) to be the most resilient and adaptable forage legume for use in association with cropping systems. Crop rotation experiments demonstrated that legumes grown in rotation with maize or rice can increase grain yields by 50% where legume was cut …

Drone And Digital Camera Imagery Estimate C3 And C4 Grass Ratios In Pastures, J. A. Bush, C. D. Teutsch, S. R. Smith, J. C. Henning

IGC Proceedings (1977-2023)

The following study investigates the accuracy and practicality of exploiting the color dichotomy present between C3 and C4 grass species to estimate their respective proportions from drone or camera captured imagery. Understanding the proportions of C3 and C4 grasses in pastures is vital to sound decision making for livestock production. The ability to monitor these proportions remotely will also allow for large scale monitoring as well as detection of changes in botanical composition over time and in response to weather events, management, or climate change. A free green canopy cover (GCC) analyzing software, Canopeo, was used to quantify green plants …

Ecosystem Services And Life Cycle Assessment Of Perennial And Annual Cropping Systems, M. Berti, A. Cecchin

IGC Proceedings (1977-2023)

Corn cultivation has negative impacts to the environment, such as nitrate leaching, soil erosion, and nitrous oxide emissions. Perennial crops such as alfalfa (Medicago sativa L.) reduce annual disturbance of soil, which affects many biogeochemical cycles that are key to provide resilience and stability to cropping systems. Four three-year crop sequences were evaluated. 1) Corn-soybean-corn (CSC); 2) alfalfa-alfalfa-alfalfa (AAA); 3) Corn-spring planted alfalfa-alfalfa (CAA); and 4) Corn-intercropped/alfalfa-alfalfa-alfalfa (CAIAA). Modeling of C and N cycles were conducted with the Denitrification-Decomposition (DNDC) model and global warming potential (GWP) was estimated using life cycle assessment (LCA) methodology. The soil organic carbon (SOC) balance …

Choosing The Best Online Platform, L. L. Baxter, A. Best

IGC Proceedings (1977-2023)

Social media is a powerful tool that enables forage-livestock researchers and Extension specialists to connect with a wide audience of producers, Extension personnel, colleagues, and industry partners. This presentation in the thematic session on “Understanding the role of social media and digital resources in forage education and promotion” will provide an overview of popular social media platforms (Facebook, Twitter, Instagram, TikTok, and YouTube) and discuss how to transform impactful research and Extension programming into effective social content before leading into the panel discussion.

Role Of Social Media And Digital Resources In Forage Education, L. L. Baxter

IGC Proceedings (1977-2023)

Social media and digital resources are powerful tools that enable forage-livestock researchers and Extension specialists to connect with a wide audience of producers, Extension personnel, colleagues, and industry partners. This presentation in the thematic session on “Understanding the role of social media and digital resources in forage education and promotion” will focus on the role digital resources play in forage education.

The Nutritional Dynamic Is Key For Use Optimal Forage And Increase Of Meat Production, Bernal-Flores Alvaro, E. A. Pizarro, Quero Carillo Raymundo, Pérez Rodríguez Paulino

IGC Proceedings (1977-2023)

The nutritional content grass could be considered a key tool to determine the optimal forage use, based on the requirements of the cattle to maximize production and achieve a highly productive and profitable livestock. The degradation protein complex associated with autophagy plant determines to a great extent the protein content of the grass over time, being priority found the value nutritional required for the livestock for intensification the animal production. The crude protein requirements (CP, 13.5%) to cover nutritional needs in cattle, was established between 28±1 y 30±1 for the dry period and wet period respectively in Camello® hybrid grass. …

Regenera+.Uy: Designing A Co-Innovation Process To Apply The Principles Of Regenerative Livestock Production, Oscar Blumetto, M. Bustamante, A. Castagna, D. Caresani, G. Ciappesoni, R. Baptista, I. De Barbieri

IGC Proceedings (1977-2023)

Consumers around the world are beginning to demand products whose production systems have environmental guarantees. Among them, those derived from regenerative agriculture have a growing demand in many markets. A comprehensive environmental assessment was carried out in 9 case studies of mixed livestock production farms (cattle and sheep) in Uruguay as a basis for the development of a system redesign process following the principles of regenerative agriculture. The results show that emission intensity was 16.0, 10.5, and 49.2 kg CO2 eq kg-1 of beef, sheep meat, and greasy wool, respectively. Also, a simulation exercise shows a significative reduction of emission …

Estimating Forage Biomass Using Unmanned Ground And Aerial Vehicles, B. A. Koc, J. Singh, M. J. Aguerre,

IGC Proceedings (1977-2023)

The assessment of the amount of biomass in the field is one of the critical factors that helps to manage and optimize numerous operations associated with forage management in the livestock industry. Pasture management decisions about stocking rate, grazing duration, and fertilizer application rate depend on accurate forage availability measurements. The objective of this study was to develop different nondestructive methods of forage biomass estimation using unmanned vehicles based on the relationship between crop height (CH) and the measured above-ground biomass. The unmanned vehicle-based methods were developed and tested on Alfalfa (Medicago Sativa) and Tall Fescue (Schedonorus …

Genetic Modification – Applications For Forage And Grassland Production Systems, J. R. Caradus

IGC Proceedings (1977-2023)

Genetic modification has been extensively used in crops for 25 years but has rarely been a technology used to advance trait expression in forage and grassland species. The exceptions are the use of herbicide tolerance and low lignin traits in alfalfa which are currently commercially available. In crop species genetic modification has been a valuable option for delivering improved economic and environmental outcomes through providing solutions for many of the challenges facing mankind. There are a many beneficial characteristics that genetic modification has the potential to provide in forage and grassland species. Managing these in the environment and understanding consumer …

A Framework For Promoting Diverse Perennial Circular Forage Systems For More Resilient Agricultural Landscapes: Developing Extension And Educational Tools For Resilience And Sustainability, Cassida K. A., W. Lamp, S. Gruss

IGC Proceedings (1977-2023)

The Resilience CAP Team seeks to use diverse, perennial, circular forage systems (DPCFS) to enhance biodiversity, improve soil and plant health, support ecosystem service, all towards achieving greater resilience to global change and improving the farm economy and quality of life. Our project will design a transdisciplinary framework that combines agronomic, ecological, economic, and sociological factors to achieve greater resilience and stability in agricultural systems through use of DPCFS. In this paper, we describe two of the project’s six objectives. Objective 5 is our extension/outreach arm where we will develop extension media, activities, and actionable decision tools to communicate concepts …

Convalescing Soil Functionality Of Degraded Lands: An Experience From Semi-Arid India, A. Chandra, H. Baradwal, A. Ghosh, A. K. Singh, S. S. Manjangouda

IGC Proceedings (1977-2023)

Land loss is not only whittling away India’s gross domestic product by 2.5% every year and affecting its crop yield but also exacerbating climate change events in the country. To test applicability of alternate land use systems for improving soil functionality in restored ecologies, soils were sampled from the 0-15, 15-30 and 30-45 cm layers of Leucaena leucocephala (LL), Hardwickia binata (HB), Emblica officinalis (EO), Azadiracta indica (AI) based silviculture systems, Acacia nilotica-based silvipasture systems (AN), and natural grassland (NG) and compared with a fallow land (F). They were evaluated for carbon management index (CMI), nutrient supply capacity (NSC), …

Stoloniferous Forage Legumes For Sustainable Mixed Pastures In The Tropics, R. M. Boddey, C De P Rezende, J. Marques Pereira, C. A. Dos Santos, Animal Husbandry Station Of The Extreme South Of Bahia, Brazil, I. O. Ramalho, R. M. Macedo, B. C. G. Homem, D. R. Casagrande, S. Urquiaga, B. J. R. Alves

IGC Proceedings (1977-2023)

Brazil has over 80 million ha of tropical pastures formed with species of Brachiaria (syn. Urochloa), mostly grazed by beef cattle and with low fertilizer inputs, especially nitrogen. Recent investigations by our team show that stoloniferous legumes such as forage peanut (Arachis pintoi) and Desmodium ovalifolium are able to persist in mixed swards with Brachiaria brizantha (cv. Marandu) if grazing height is regulated (maximum 30 cm) so that radiation can reach the soil surface allowing stolons to take root. These legumes can persist in mixed pastures and produce milk or animal weight gains similar to the application …

Ecosystem Benefits Of Invasive Annual Grass Removal, S. L. Clark

IGC Proceedings (1977-2023)

Invasive winter annual grasses (IAGs) are altering rangeland ecosystems across millions of hectares in the western US. These winter annuals outcompete native plants for soil moisture and nutrients, leading to devastating impacts on ecosystem functions. The IAG seedbank is short-lived and often does not persist beyond 3 years. Past tools for IAG control have only provided short-term control or caused injury to the native plant community, making it difficult for researchers to assess the ecosystem benefits of IAG removal. A newer herbicide option, indaziflam, provides IAG control for three or more years. Indaziflam’s extended soil residual control and tolerance of …

Exploring Profitable, Sustainable Livestock Businesses In An Increasingly Variable Climate, B. R. Cullen, M. T. Harrison, D. Mayberry, D. Cobon, N. Reichelt, A. Sinnet, Km Christie, F. Bilotto, D-A An-Vo, C. Stokes, L. Perry, T. Davison

IGC Proceedings (1977-2023)

Livestock production systems will need to change in many regions of the world to meet the dual challenges of adaptation to a changing climate and reducing net greenhouse gas (GHG) emissions. The ‘Nexus project’ is exploring these options using seven case studies in eastern Australia spanning a range of production systems from semi-arid beef production in northern Australia to mixed beef and sheep production in cool temperate climates of southern Australia. Regional reference groups, made up of 4-6 local farmers and advisers, identified a series of farm systems changes that could be made to meet these challenges. Options were categorised …