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Full-Text Articles in Life Sciences

Mycobacteriophage Pembroke, An A3 Cluster Phage Infecting Mycobacterium Smegmatis, Marly Cassford '25 Apr 2024

Mycobacteriophage Pembroke, An A3 Cluster Phage Infecting Mycobacterium Smegmatis, Marly Cassford '25

Chemistry & Biochemistry Student Scholarship

Marly Cassford ’25, Biochemistry major
Faculty Mentor: Dr. Kathleen Cornely, Chemistry and Biochemistry


Investigating Pathways Regulating Size-Dependent Accumulation Of Mitotic Activator Cdc25, Paige Duggan '26, Logan Anglemyer '26, Kayleigh Goebelbecker '24 Apr 2024

Investigating Pathways Regulating Size-Dependent Accumulation Of Mitotic Activator Cdc25, Paige Duggan '26, Logan Anglemyer '26, Kayleigh Goebelbecker '24

Biology Student Scholarship

Paige Duggan ’26, Biology major, Neuroscience and Math minor
Logan Anglemyer ’26, Neuroscience major, Spanish minor
Kayleigh Goebelbecker ’24, Biology major
Faculty Mentor: Dr. Kristi Miller, Biology


Effects Of Clec7a Deficiency In Cerebellar Microglia Development, Julia Carson '25 Apr 2024

Effects Of Clec7a Deficiency In Cerebellar Microglia Development, Julia Carson '25

Biology Student Scholarship

Julia Carson ’25, Biology major
Faculty Mentor: Dr. Ileana Soto Reyes, Biology


Exploring Neural Patterns: Rat Brain Activation During A Transitive Inference Task, Yamilet Nieves Vega '26 Apr 2024

Exploring Neural Patterns: Rat Brain Activation During A Transitive Inference Task, Yamilet Nieves Vega '26

Biology Student Scholarship

Yamilet Nieves ’26, Neuroscience and Health Policy and Management major
Faculty Mentor: Dr. Victoria Templer, Neuroscience


Natural Antioxidants, Oybek Zufarov, Kamar Serkayev Apr 2024

Natural Antioxidants, Oybek Zufarov, Kamar Serkayev

Technical science and innovation

Antioxidants sourced from nature play a pivotal role in maintaining human health. Enzymatic antioxidants like catalase and peroxidase, alongside high-molecular-weight non-enzymatic antioxidants such as albumin and ferritin, bolster cellular defense mechanisms. Phenolic compounds, plentiful in plants, act as antioxidants and fall into different categories like phenolic acids, flavonoids, tannins, lignans, and lignin. These compounds showcase antioxidant prowess by neutralizing free radicals and binding metals, with their efficacy influenced by structural nuances and environmental factors. Moreover, flavonoids, tannins, lignans, diterpenes, and carotenoids stand out for their antioxidant prowess. Carotenoids like lycopene, present in tomatoes, display notable antioxidant potency, contributing to health …


Identification Of Plant Growth Promoting Rhizobacteria For Ballona Wetlands Restoration, Caroline Ehren, Michelle Lum Apr 2024

Identification Of Plant Growth Promoting Rhizobacteria For Ballona Wetlands Restoration, Caroline Ehren, Michelle Lum

Honors Thesis

The Ballona Wetlands Ecological Reserve (BWER) is home to many California native plant species which contribute to ecosystem services of flood and erosion mitigation, water quality improvement, carbon sequestration, and habitat provisions for threatened and endangered species. Plant growth promoting rhizobacteria (PGPR) improve plant tolerance to abiotic stressors and suppress pathogens through the alteration of nutrient absorption, water uptake, and enzymatic activity, and have potential in conservation strategies by aiding revegetation methods. Eight bacterial strains were isolated from native Frankenia salina and Baccharis pilularis in the BWER to determine whether these microbes act as PGPR. The strains were characterized using …


Amplon: Amplifying Dna With Multiarm Priming And Looping Optimization Of Nucleic Acid, Mert Tunca Doganay, Ethan Roman, Andrea M. Hujer, Robert A. Bonomo, Mohamed S. Draz Apr 2024

Amplon: Amplifying Dna With Multiarm Priming And Looping Optimization Of Nucleic Acid, Mert Tunca Doganay, Ethan Roman, Andrea M. Hujer, Robert A. Bonomo, Mohamed S. Draz

Faculty Scholarship

Nucleic acid amplification, the bedrock of biotechnology and molecular diagnostics, surges in applications—especially isothermal approaches—heightening the demand for advanced and precisely engineered methods. Here, a novel approach for amplifying DNA with multiarm priming and looping optimization of nucleic acid (AMPLON) is presented. AMPLON relies on a novel polymeric material with unique set of multiarm polyethylene glycol–DNA primers for efficient DNA amplification under isothermal conditions. Each arm carries single-stranded DNA complementing the sense or antisense sequence of the target DNA. The amplification reaction begins with antisense arms binding to the target DNA, forming a template for sense-carrying arms to direct multiarm …


Impact Of Changing Climate On Bryophyte Contributions To Terrestrial Water, Carbon, And Nitrogen Cycles, Mandy L. Slate, Anita Antoninka, Lydia Bailey, Monica B. Berdugo, Des A. Callaghan, Mariana Cárdenas, Matthew W. Chmielewski, Nicole J. Fenton, Hannah Holland-Moritz, Samantha Hopkins, Mélanie Jean, Bier Ekaphan Kraichak, Zoë Lindo, Amelia Merced, Tobi Oke, Daniel Stanton, Julia E. Stuart, Daniel Tucker, Kirsten K. Coe Apr 2024

Impact Of Changing Climate On Bryophyte Contributions To Terrestrial Water, Carbon, And Nitrogen Cycles, Mandy L. Slate, Anita Antoninka, Lydia Bailey, Monica B. Berdugo, Des A. Callaghan, Mariana Cárdenas, Matthew W. Chmielewski, Nicole J. Fenton, Hannah Holland-Moritz, Samantha Hopkins, Mélanie Jean, Bier Ekaphan Kraichak, Zoë Lindo, Amelia Merced, Tobi Oke, Daniel Stanton, Julia E. Stuart, Daniel Tucker, Kirsten K. Coe

Michigan Tech Publications

Bryophytes, including the lineages of mosses, liverworts, and hornworts, are the second-largest photoautotroph group on Earth. Recent work across terrestrial ecosystems has highlighted how bryophytes retain and control water, fix substantial amounts of carbon (C), and contribute to nitrogen (N) cycles in forests (boreal, temperate, and tropical), tundra, peatlands, grasslands, and deserts. Understanding how changing climate affects bryophyte contributions to global cycles in different ecosystems is of primary importance. However, because of their small physical size, bryophytes have been largely ignored in research on water, C, and N cycles at global scales. Here, we review the literature on how bryophytes …


Buying Revenue Protection (Rp) Versus Buying The Rp With Harvest Price Exclusion (Rphpe) Version Of Multi-Peril Crop Insurance, Matthew Stockton, Shannon Sand Apr 2024

Buying Revenue Protection (Rp) Versus Buying The Rp With Harvest Price Exclusion (Rphpe) Version Of Multi-Peril Crop Insurance, Matthew Stockton, Shannon Sand

Cornhusker Economics

In a conversation with one of the TAPS participants about Multi-Peril Crop Insurance (MPCI) he suggested that you would never recommend RPHPE, due to the risk associated with a higher fall harvest price compared to the spring or predicted price. Since the year 2000, this has occurred about one-third of the time. This price reversal may alter indemnity size considerably, depending on which insurance is selected and if one qualifies for an indemnity. The discussion with the TAPS participant focused on the concern of risk exposure from pre-selling uninsured grain due to an unexpected increase in harvest price. This relates …


Exploring Leaf Anthocyanin Concentrations And Light Effects On Lettuce Growth, Peyton Lou Palsha, Marc W. Van Iersel, Ryan Dickson, Lynn Seymour, Melanie Yelton, Rhuanito Soranz Ferrarezi Apr 2024

Exploring Leaf Anthocyanin Concentrations And Light Effects On Lettuce Growth, Peyton Lou Palsha, Marc W. Van Iersel, Ryan Dickson, Lynn Seymour, Melanie Yelton, Rhuanito Soranz Ferrarezi

Horticulture Faculty Publications and Presentations

Anthocyanins are secondary metabolites classified as water-soluble, non-photosynthetic pigments with the potential ability to shield chloroplasts from excess light energy. This study investigated the morphological and physiological responses of six lettuce (Lactuca sativa) cultivars with different leaf anthocyanin contents grown in a greenhouse under different supplemental photosynthetic photon flux densities (PPFD). Cultivars ‘Cherokee’, ‘Teodore’, ‘Rex’, and ‘Rouxai’ decreased in specific leaf area with increasing PPFD, respectively. We observed that growth in cultivars with higher leaf anthocyanin content (‘Cherokee’ and ‘Rouxai’) increased with increasing PPFD. Light use efficiency (LUE) is an important physiological parameter affecting biomass accumulation, and cultivars ‘Cherokee’, ‘Rex’, …


Genomic Insights Into Oxalate Content In Spinach: A Genome-Wide Association Study And Genomic Prediction Approach, Haizheng Xiong, Kenani Chiwina, Waltram Ravelombola, Yilin Chen, Ibtisam Alatawi, Qun Luo, Theresa M. Phiri, Beiquan Mou, Ainong Shi Apr 2024

Genomic Insights Into Oxalate Content In Spinach: A Genome-Wide Association Study And Genomic Prediction Approach, Haizheng Xiong, Kenani Chiwina, Waltram Ravelombola, Yilin Chen, Ibtisam Alatawi, Qun Luo, Theresa M. Phiri, Beiquan Mou, Ainong Shi

Horticulture Faculty Publications and Presentations

Oxalate content in spinach is a key trait of interest due to its relevance to human health. Understanding the genetic basis of it can facilitate the development of spinach varieties with reduced oxalate levels. In pursuit of understanding the genetic determinants, a diverse panel comprising 288 spinach accessions underwent thorough phenotyping of oxalate content and were subjected to whole-genome resequencing, resulting in a comprehensive dataset encompassing 14 386 single-nucleotide polymorphisms (SNPs). Leveraging this dataset, we conducted a genome-wide association study (GWAS) to identify noteworthy SNPs associated with oxalate content. Furthermore, we employed genomic prediction (GP) via cross-prediction, utilizing five GP …


Smokejumper Obituary: Seagraves, John Kootenai “Jack” (Mccall 1963), National Smokejumper Association Apr 2024

Smokejumper Obituary: Seagraves, John Kootenai “Jack” (Mccall 1963), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.


Effective Dispersal Patterns In Prairie Plant Species Across Human-Modified Landscapes., Elizabeth C. Hendrickson, Mitchell B. Cruzan Apr 2024

Effective Dispersal Patterns In Prairie Plant Species Across Human-Modified Landscapes., Elizabeth C. Hendrickson, Mitchell B. Cruzan

Biology Faculty Publications and Presentations

Effective dispersal among plant populations is dependent on vector behaviour, landscape features and availability of adequate habitats. To capture landscape feature effects on dispersal, studies must be conducted at scales reflecting single-generation dispersal events (mesoscale). Many studies are conducted at large scales where genetic differentiation is due to dispersal occurring over multiple generations, making it difficult to interpret the effects of specific landscape features on vector behaviour. Genetic structure at the mesoscale may be determined by ecological and evolutionary processes, such as the consequences of vector behaviour on patterns of gene flow. We used chloroplast haplotypes and nuclear genome SNP …


Development And Structure Of Spinal Interneuron Connectivity In Larval Zebrafish, Saul Bello Rojas Apr 2024

Development And Structure Of Spinal Interneuron Connectivity In Larval Zebrafish, Saul Bello Rojas

Arts & Sciences Graduate Student Theses and Dissertations

In vertebrates, spinal interneurons are essential for the initiation and propagation of locomotor activity with each class of interneurons serving its own unique role. Ipsilateral interneurons function to control locomotor speed; whereas, commissural interneurons aid in left – right alternation. To date, most studies have been aimed at studying the impact of each individual class of interneurons onto motor neurons. However, not much work has revolved around studying interneuron – interneuron connectivity among the various cardinal classes. Furthermore, it remains unknown how the connectivity of interneurons changes along their entire axonal reach. This thesis aims to address the developmental patterns …


The Swi/Snf Atp-Dependent Chromatin Remodeling Complex In Cell Lineage Priming And Early Development, Dhurjhoti Saha, Srinivas Animireddy, Blaine Bartholomew Apr 2024

The Swi/Snf Atp-Dependent Chromatin Remodeling Complex In Cell Lineage Priming And Early Development, Dhurjhoti Saha, Srinivas Animireddy, Blaine Bartholomew

Faculty, Staff and Student Publications

ATP dependent chromatin remodelers have pivotal roles in transcription, DNA replication and repair, and maintaining genome integrity. SWI/SNF remodelers were first discovered in yeast genetic screens for factors involved in mating type switching or for using alternative energy sources therefore termed SWI/SNF complex (short for SWItch/Sucrose NonFermentable). The SWI/SNF complexes utilize energy from ATP hydrolysis to disrupt histone-DNA interactions and shift, eject, or reposition nucleosomes making the underlying DNA more accessible to specific transcription factors and other regulatory proteins. In development, SWI/SNF orchestrates the precise activation and repression of genes at different stages, safe guards the formation of specific cell …


Fostering Effective And Sustainable Scientific Collaboration And Knowledge Exchange: A Workshop-Based Approach To Establish A National Ecological Observatory Network (Neon) Domain-Specific User Group, Alison Donnelly, Ankur R. Desai, Katherine A. Heckman, Lucas E. Nave, Michael J. Cramer, Marie Faust, Peter Weishampel, Caleb Slemmons, Christian G. Andresen, Edward Ayres, Stacy Cotey, Kathryn M. Docherty, Joshua Hatzis, Kathryn Hofmeister, Jalene M. Lamontagne, John Lenters, Noah R. Lottig, Amy Marcarelli, Jessica Miesel, Jason Riddle, Meghan Salmon-Tumas, Mike D. Sanclements, Subash Sapkota, Mark D. Schwartz, Puja Sharma, Ojaswee Shrestha, Geoffrey Vincent, Angela Waupochick, Ting Zheng, Ye Zhiwei Apr 2024

Fostering Effective And Sustainable Scientific Collaboration And Knowledge Exchange: A Workshop-Based Approach To Establish A National Ecological Observatory Network (Neon) Domain-Specific User Group, Alison Donnelly, Ankur R. Desai, Katherine A. Heckman, Lucas E. Nave, Michael J. Cramer, Marie Faust, Peter Weishampel, Caleb Slemmons, Christian G. Andresen, Edward Ayres, Stacy Cotey, Kathryn M. Docherty, Joshua Hatzis, Kathryn Hofmeister, Jalene M. Lamontagne, John Lenters, Noah R. Lottig, Amy Marcarelli, Jessica Miesel, Jason Riddle, Meghan Salmon-Tumas, Mike D. Sanclements, Subash Sapkota, Mark D. Schwartz, Puja Sharma, Ojaswee Shrestha, Geoffrey Vincent, Angela Waupochick, Ting Zheng, Ye Zhiwei

Michigan Tech Publications

The decision to establish a network of researchers centers on identifying shared research goals. Ecologically specific regions, such as the USA’s National Ecological Observatory Network’s (NEON’s) eco-climatic domains, are ideal locations by which to assemble researchers with a diverse range of expertise but focused on the same set of ecological challenges. The recently established Great Lakes User Group (GLUG) is NEON’s first domain specific ensemble of researchers, whose goal is to address scientific and technical issues specific to the Great Lakes Domain 5 (D05) by using NEON data to enable advancement of ecosystem science. Here, we report on GLUG’s kick …


Microplastic Quantification On The Effect Of Endoparasite Communities In Florida Seabirds, Sarah N. Prieto Apr 2024

Microplastic Quantification On The Effect Of Endoparasite Communities In Florida Seabirds, Sarah N. Prieto

All HCAS Student Capstones, Theses, and Dissertations

Microplastics are being studied in a variety of different projects to better understand their impact and threat to wildlife species. Although there is an understanding that microplastics are affecting our wildlife, there are still questions about how coastal seabirds come to ingest them and how the ingestion is altering critical biological processes, such as that for endoparasite communities. This project aims to determine a better understanding of two main objectives: assessment of the presence of secondary ingestion of microplastics in coastal seabirds due to the fish species they prey on and relationship between microplastics and endoparasite communities' structure and state …


Monotypic: Evolution And Adaptations Of The World's Most Distinctive Species, Emerson Harman, Amanda Almon Apr 2024

Monotypic: Evolution And Adaptations Of The World's Most Distinctive Species, Emerson Harman, Amanda Almon

STEM Student Research Symposium Posters

"Monotypic: Evolution and Adaptations of the World’s Most Distinctive Species" is a BFA and Honors Capstone exhibition focused on introducing the public to the unique qualities of plants and animals that are the sole extant representative of their taxonomic family or higher classification. The exhibition is centered around the use of illustrative infographics to effectively deliver scientific information in an engaging manner to a wide audience. "Monotypic" explores the individual evolutionary adaptations that make each of these lineages so distinct from any of their living relatives while also touching on the interactions with their environments, relationships with other species, and …


Estimating Changing Marshland Habitat And Conservation Potential For Diamondback Terrapins In New Jersey Under Climate Change And Development Pressures, Jacqueline Ganter Apr 2024

Estimating Changing Marshland Habitat And Conservation Potential For Diamondback Terrapins In New Jersey Under Climate Change And Development Pressures, Jacqueline Ganter

STEM Student Research Symposium Posters

The diamondback terrapin, a brackish water turtle native to the eastern US, is listed as a species of ‘special concern’ in the state of New Jersey, due to decreasing habitat from development and changing climatic conditions. Diamondback terrapins reside in saline marshes and wetlands and nest in sandy substrate, primarily beaches and dunes, in June and July. The state of New Jersey is vulnerable to both sea level rise, leaving diamondback terrapin habitats and nesting areas at risk of inundation under future climate scenarios, and, as the most densely populated state, subject to continual development pressures on potentially conservable land. …


Improving The Drug Antipyrine: Synthesis Of N2-Aryl Analogs Through Oxidation Of Dihydroantipyrines, Eli Mans Apr 2024

Improving The Drug Antipyrine: Synthesis Of N2-Aryl Analogs Through Oxidation Of Dihydroantipyrines, Eli Mans

Student Academic Conference

Idiopathic Pulmonary Fibrosis (IPF) is a progressive and fatal lung disease that affects thousands of people worldwide. Current drugs are used in clinical settings to treat IPF but these drugs have low efficacy and a high monetary costs. The molecule antipyrine has been identified by colleagues at Mayo Clinic as an early-stage drug candidate for treatment for IPF. The Jasperse group is synthesizing analogs of antipyrine to create a drug library for improved IPF treatment. A novel three step process via a silyl enol ether intermediate has been developed to convert a C-C bond to a C=C bond between C4-C5 …


From Field To Fashion: A Journey In Sustainable Design And Regional Understanding, Lily Turner Apr 2024

From Field To Fashion: A Journey In Sustainable Design And Regional Understanding, Lily Turner

Individually Designed Interdepartmental Major Honors Project

As the fashion industry became globalized over the past century, it has become a major environment polluter and exposed laborers to hazardous conditions. This honors project considers sustainability in the textile industry at large and at the regional scale of the Upper Midwest. Its scholarly component offers an overview of the current textile production, details how the industry may become sustainable, and suggests practices of environmentally-conscious and ethical design. The creative component is a soil-to-soil seasonless capsule collection titled From Field View that incorporates biomimicry and interrogates the concept of place by referencing the Midwest’s flora, wool, and linen fibers.


Genetic Diversity Of United States Rambouillet, Katahdin And Dorper Sheep, Gabrielle M. Becker, Jacob W. Thorne, Joan M. Burke, Ronald M. Lewis, David R. Notter, James L. M. Morgan, Christopher S. Schauer, Whit C. Stewart, R. R. Redden, Brenda M. Murdoch Apr 2024

Genetic Diversity Of United States Rambouillet, Katahdin And Dorper Sheep, Gabrielle M. Becker, Jacob W. Thorne, Joan M. Burke, Ronald M. Lewis, David R. Notter, James L. M. Morgan, Christopher S. Schauer, Whit C. Stewart, R. R. Redden, Brenda M. Murdoch

Department of Animal Science: Faculty Publications

Background Managing genetic diversity is critically important for maintaining species fitness. Excessive homozygosity caused by the loss of genetic diversity can have detrimental effects on the reproduction and production performance of a breed. Analysis of genetic diversity can facilitate the identification of signatures of selection which may contribute to the specific characteristics regarding the health, production and physical appearance of a breed or population. In this study, breeds with well-characterized traits such as fine wool production (Rambouillet, N = 745), parasite resistance (Katahdin, N = 581) and environmental hardiness (Dorper, N = 265) were evaluated for inbreeding, effective population size …


Sagefire: An Agent-Based Model Of Heat Dynamics In Sagebrush Steppe Ecosystems During A Fire Event, Samuel Joseph Knuth Apr 2024

Sagefire: An Agent-Based Model Of Heat Dynamics In Sagebrush Steppe Ecosystems During A Fire Event, Samuel Joseph Knuth

Theses and Dissertations

Context: The Great Basin in the western US features arid to semi-arid climates and sagebrush steppe ecosystems. Increased fire frequency can negatively impact these ecosystems by promoting invasive species. Agent-based modeling is a valuable tool to study fire dynamics in sagebrush steppe ecosystems, offering insights in management strategies and ecosystem resilience. Objectives: We developed SageFire, an agent-based model, to simulate heat dynamics influenced by shrub cover during fires in the Great Basin. Our objectives were to accurately classify ground cover types, incorporate classified imagery into a simulation model, and accurately visualize fire intensity based on the spatial arrangement of the …


The Genomics Of Champ1: Insights Into Their Cell-Type Specificity And Developmental Trajectories, Zoe Marie Van Caugherty Apr 2024

The Genomics Of Champ1: Insights Into Their Cell-Type Specificity And Developmental Trajectories, Zoe Marie Van Caugherty

MUSC Theses and Dissertations

Chromosome alignment maintaining phosphoprotein 1(CHAMP1) is a gene that encodes a zinc finger protein that is involved in in the maintenance of kinetochore-microtubule attachment and regulating chromosome segregation in mitosis. (Itoh et al., 2011) CHAMP1 mutations have been shown to be major risk factors for neurodevelopmental disorders (NDDs) and autism spectrum disorder (ASD).(Asakura et al., 2021; Isidor et al., 2016; Levy et al., 2022) Although there is information on the link between CHAMP1 mutations and NDD, the role of CHAMP1 in regulating processes of human cortical development, namely, neurogenesis, proliferation, and electrophysiological properties of newly born neurons, is unknown. This …


Even The Ocean Is Online: Digital Representation Of The Ocean, Nevaeh Johnson, Hannah Cissell Apr 2024

Even The Ocean Is Online: Digital Representation Of The Ocean, Nevaeh Johnson, Hannah Cissell

Student Academic Conference

This presentation is about #8, the digital representation of the ocean, of the UNESCO Challenge. More research needs to be done on the ocean to preserve marine life and coastal land. We need the help of large corporations in a collaboration on a digital representation of the ocean. This will help us visualize the oceans' past, current, and possible future. A digital map of the ocean will help with us pollution, help slow down climate change, and help us prepare for environmental disasters. We could create a digital map of the ocean floor by using a multibeam or a side …


Spatial Distribution Of Soil Nutrients And Properties As A Function Of Vegetation Distribution, Fire, And Rodent Activity, Nathan O. Jones Apr 2024

Spatial Distribution Of Soil Nutrients And Properties As A Function Of Vegetation Distribution, Fire, And Rodent Activity, Nathan O. Jones

Theses and Dissertations

Fires are becoming larger and more frequent in the deserts of North America, driven largely by the expansion of invasive annual grasses. Rodent consumers can curb invasive grass expansion through plant herbivory, but the top-down effects of this pressure on soil resources are understudied. In shrub dominated deserts, islands of fertility under shrub canopies are surrounded by nutrient poor interspace soils that dictate patterns of vegetative growth. Little is known of how top-down controls from rodents and fire may interact with fertile island topography. These studies explore the effects of fire, rodent activity, and fertile island topography on plant available …


Associations Between Stress, Health Behaviors, And Quality Of Life In Young Couples During The Transition To Survivorship: Protocol For A Measurement Burst Study, Dalnim Cho, Michael Roth, Susan K Peterson, Kristofer Jennings, Seokhun Kim, Sairah Ahmed, Carlos Barcenas, Y Nancy You, Kathrin Milbury Apr 2024

Associations Between Stress, Health Behaviors, And Quality Of Life In Young Couples During The Transition To Survivorship: Protocol For A Measurement Burst Study, Dalnim Cho, Michael Roth, Susan K Peterson, Kristofer Jennings, Seokhun Kim, Sairah Ahmed, Carlos Barcenas, Y Nancy You, Kathrin Milbury

Faculty, Staff and Student Publications

BACKGROUND: Cancer is a life-threatening, stressful event, particularly for young adults due to delays and disruptions in their developmental transitions. Cancer treatment can also cause adverse long-term effects, chronic conditions, psychological issues, and decreased quality of life (QoL) among young adults. Despite numerous health benefits of health behaviors (eg, physical activity, healthy eating, no smoking, no alcohol use, and quality sleep), young adult cancer survivors report poor health behavior profiles. Determining the associations of stress (either cancer-specific or day-to-day stress), health behaviors, and QoL as young adult survivors transition to survivorship is key to understanding and enhancing these survivors' health. …


Evolution Of Chromosome-Arm Aberrations In Breast Cancer Through Genetic Network Rewiring, Elena Kuzmin, Toby M Baker, Tom Lesluyes, Jean Monlong, Kento T Abe, Michael Schwartz, Dongmei Zou, Genevieve Morin, Alain Pacis, Yang Yang, Constanza Martinez, Jarrett Barber, Hellen Kuasne, Rui Li, Mathieu Bourgey, Anne-Marie Fortier, Peter G Davison, Atilla Omeroglu, Marie-Christine Guiot, Quaid Morris, Claudia L Kleinman, Sidong Huang, Anne-Claude Gingras, Jiannis Ragoussis, Guillaume Bourque, Peter Van Loo, Morag Park Apr 2024

Evolution Of Chromosome-Arm Aberrations In Breast Cancer Through Genetic Network Rewiring, Elena Kuzmin, Toby M Baker, Tom Lesluyes, Jean Monlong, Kento T Abe, Michael Schwartz, Dongmei Zou, Genevieve Morin, Alain Pacis, Yang Yang, Constanza Martinez, Jarrett Barber, Hellen Kuasne, Rui Li, Mathieu Bourgey, Anne-Marie Fortier, Peter G Davison, Atilla Omeroglu, Marie-Christine Guiot, Quaid Morris, Claudia L Kleinman, Sidong Huang, Anne-Claude Gingras, Jiannis Ragoussis, Guillaume Bourque, Peter Van Loo, Morag Park

Faculty, Staff and Student Publications

The basal breast cancer subtype is enriched for triple-negative breast cancer (TNBC) and displays consistent large chromosomal deletions. Here, we characterize evolution and maintenance of chromosome 4p (chr4p) loss in basal breast cancer. Analysis of The Cancer Genome Atlas data shows recurrent deletion of chr4p in basal breast cancer. Phylogenetic analysis of a panel of 23 primary tumor/patient-derived xenograft basal breast cancers reveals early evolution of chr4p deletion. Mechanistically we show that chr4p loss is associated with enhanced proliferation. Gene function studies identify an unknown gene, C4orf19, within chr4p, which suppresses proliferation when overexpressed-a member of the PDCD10-GCKIII kinase module …


Six-Year Follow-Up And Subgroup Analyses Of A Phase 2 Trial Of Venetoclax For Del(17p) Chronic Lymphocytic Leukemia, Stephan Stilgenbauer, Eugen Tausch, Andrew W Roberts, Matthew S Davids, Barbara Eichhorst, Peter Hillmen, Johannes Schetelig, Sebastian Böttcher, Arnon P Kater, Yanwen Jiang, Michelle Boyer, Relja Popovic, Majd T Ghanim, Michael Moran, Wendy J Sinai, Xifeng Wang, Nabanita Mukherjee, Brenda Chyla, William G Wierda, John F Seymour Apr 2024

Six-Year Follow-Up And Subgroup Analyses Of A Phase 2 Trial Of Venetoclax For Del(17p) Chronic Lymphocytic Leukemia, Stephan Stilgenbauer, Eugen Tausch, Andrew W Roberts, Matthew S Davids, Barbara Eichhorst, Peter Hillmen, Johannes Schetelig, Sebastian Böttcher, Arnon P Kater, Yanwen Jiang, Michelle Boyer, Relja Popovic, Majd T Ghanim, Michael Moran, Wendy J Sinai, Xifeng Wang, Nabanita Mukherjee, Brenda Chyla, William G Wierda, John F Seymour

Faculty, Staff and Student Publications

Chromosome 17p deletion (del[17p]) is associated with poor prognosis in patients with chronic lymphocytic leukemia (CLL). Venetoclax is approved for treatment of previously untreated and relapsed/refractory (R/R) CLL, including patients with del(17p), based on the open-label, multicenter, phase 2 M13-982 trial (NCT01889186). Here, we detail the 6-year follow-up analysis for M13-982. A total of 158 patients with previously untreated (n = 5) or R/R (n = 153) del(17p) CLL received 400 mg venetoclax daily after initial ramp-up until progressive disease. After a median follow-up of 70 months, the best objective response rate (ORR) was 77% (21% complete remission …


Assessment Of Thermal Preferences And Critical Temperature Tolerance Polygons On Mangrove Fish And Invertebrates From South Florida, Jailynn Konkler Apr 2024

Assessment Of Thermal Preferences And Critical Temperature Tolerance Polygons On Mangrove Fish And Invertebrates From South Florida, Jailynn Konkler

All HCAS Student Capstones, Theses, and Dissertations

Mangroves serve as important nursery habitats for several species of subtropical fishes and invertebrates. Southeastern Florida mangrove environments have experienced an increasing frequency of strong hot and cold weather front systems, but little information is known about the temperature thresholds for mangrove-associated prey species that lethally disrupts homeostasis. To assess the vulnerability of mangrove-associated prey species to these short-duration temperature fluctuations, critical thermal methodology (CTM) was used to determine thermal tolerances for two fishes and two invertebrates, using loss of equilibrium (LOE) as the endpoint to determine CTmax and CTmin values as a survivable proxy for death. Physiological tolerances were …