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Articles 26971 - 27000 of 255951
Full-Text Articles in Life Sciences
Changes In Soil Chemical Attributes, Horticultural Performance And Fruit Yield Of Peach Cultivars Following Preplant And Annual Applications Of Composted Mulch Amendments, Jeffrey Hopkins
All Theses
Southeastern peach orchards often have poor soil quality due to native soil composition, intensive farming practices and generational replanting of trees in the same locations. This study investigated using mulch amendments to improve the chemical and physical quality of soil prior to planting a new peach orchard. At the beginning of the four-year study, a single-ground municipal composted mulch was incorporated into the soil at two different rates and three cultivars of peaches, ‘Rubyprince’, ‘Julyprince’, and ‘BigRed’ were planted on berms. Thereafter, the same mulch product was annually applied to the top of the berms at two different rates to …
The Effect Of Chlorine Dioxide On Sliced Tomatoes Used In Retail And Foodservice, Charles Mattocks
The Effect Of Chlorine Dioxide On Sliced Tomatoes Used In Retail And Foodservice, Charles Mattocks
All Theses
As food prices continue to rise, many consumers are looking at ways to cut back on spending and many look to how much they spend on food. Food waste in an average American household of four leads to about $1,500 worth of unused/wasted food annually,
This study was conducted to see how the use of Chlorine Dioxide (ClO2) could be used to treat and extend the shelf life of freshly sliced tomatoes for food service applications. Prior research in this regard has looked at whole tomatoes as opposed to sliced varieties, and many have not utilized a sensory …
Photobiomodulation Of Bovine Oocytes During Maturation Increases Atp Content And Enhances Subsequent Embryonic Development, Kendall Richey
Photobiomodulation Of Bovine Oocytes During Maturation Increases Atp Content And Enhances Subsequent Embryonic Development, Kendall Richey
All Theses
Bovine in-vitro production(IVP) of embryos is a growing field for producing offspring with desirable genetics in the cattle industries. While IVP is effective, oocyte cytoplasmic maturation is compromised, and bovine oocytes matured in-vitro have reduced metabolic activity than those matured in-vivo. Mitochondria are the central unit of oocyte metabolism, producing ATP through OXPHOS. Photobiomodulation is a light treatment reported to improve metabolic activity. In five experiments, we measured the effects of photobiomodulation treatment with red LED at 16-(L-16) and 20 h(L-20) of bovine oocyte in-vitro maturation on subsequent embryonic development, mitochondrial activity and nuclear progression. Bovine COCs were aspirated …
Optimization Of Coral Restoration Along The Florida Reef Tract, Raymond Barry Banister
Optimization Of Coral Restoration Along The Florida Reef Tract, Raymond Barry Banister
Theses and Dissertations
Historically, the reefs of Florida were dominated by two framework-building corals, Acropora cervicornis and A. palmata. However, these two populations have declined by 95% since the 1970s. The predominant contributors to the coral decline have been ocean warming and disease. In response to the decline, restoration organizations were established to improve survival, growth, and reproduction. Yet, there are gaps in current restoration practices and our knowledge of effective restoration techniques. This study uses large datasets to develop models that predict the most optimal locations for coral restoration in Florida and examines the relationships between the occurrence of wild acroporids …
Concepts In Animal Parasitology: Master Bibliography, Sue Ann Gardner
Concepts In Animal Parasitology: Master Bibliography, Sue Ann Gardner
Concepts in Animal Parasitology
Master bibliography for the open educational resource/open access textbook Concepts in Animal Parasitology, Scott L. Gardner and Sue Ann Gardner, editors, published by Zea Books, Lincoln, Nebraska, United States, 2024. This includes the references from literature cited and suggested supplemental reading.
The Effect Of Yamanaka Factors On The Metastatic Potential Of Breast Cancer Cells, Riley Mendonca
The Effect Of Yamanaka Factors On The Metastatic Potential Of Breast Cancer Cells, Riley Mendonca
Undergraduate Honors Theses
The mortality associated with cancer is most commonly a result of it spreading to other tissues and organs in a process known as metastasis. For carcinomas to do this they must first break through the basement membrane containing them to interact with the stroma. This is known as an epithelial-mesenchymal transition and occurs when carcinomas suppress their original epithelial qualities in order to adopt more mesenchymal ones. This involves cancers dedifferentiating from their original cell type to lose the specialized features that distinguished them and where they came from. As cancers become more invasive, this dedifferentiation becomes more pronounced. Recent …
Conserving One Of Hawai'i'S Last Endemic Ducks: Genetics And Habitat Associations Of Koloa, Feral Mallards, And Their Hybrids, Kristi Fukunaga
Conserving One Of Hawai'i'S Last Endemic Ducks: Genetics And Habitat Associations Of Koloa, Feral Mallards, And Their Hybrids, Kristi Fukunaga
Open Access Theses & Dissertations
Increases in anthropogenic hybridization through introduced species have accelerated the loss of genetic diversity and reductions in population size of native species that are already threatened by population and genetic diversity decline. Fertile hybrids that are common among waterfowl (order Anseriformes) are especially worrisome. A prime example is the endangered Hawaiian duck (Anas wyvilliana; “koloa maoli”), which is the remaining endemic duck species on the main Hawaiian Islands and is threatened by genetic extinction through ongoing hybridization with feral mallards (Anas platyrhynchos). Of note, koloa populations are known to be strongly male-biased (3:1), and this sex bias is known to …
Prelimbic Cortex Neuronal Assemblies In Behaviors Predictive Of Drug-Seeking Before And After Cocaine Self-Administration, Karla J. Galvan
Prelimbic Cortex Neuronal Assemblies In Behaviors Predictive Of Drug-Seeking Before And After Cocaine Self-Administration, Karla J. Galvan
Open Access Theses & Dissertations
Literature has established that there are certain behaviors that are predictive of drug seeking and relapse such as impulsivity, distress tolerance (DT), Pavlovian conditioned approach (PCA), anxiety, and sensation-seeking. However, few studies have examined the behavioral interactions among these tasks and drug-seeking, and none have examined the neural interactions in the prelimbic cortex, which has an essential role in drug-seeking and is implicated in each of the aforementioned behaviors of interest.We therefore hypothesized that certain behaviors including high impulsivity, low distress tolerance, high anxiety, and high locomotor activity would predict high cocaine-seeking. We further hypothesized that the neuronal activity in …
Assessing Nordihydroguaiaretic Acid Properties And Its Potential Therapeutic Effect For Glioblastoma, Jose Arturo Guerrero
Assessing Nordihydroguaiaretic Acid Properties And Its Potential Therapeutic Effect For Glioblastoma, Jose Arturo Guerrero
Open Access Theses & Dissertations
This study employs a combination of theoretical and experimental analysis to spectroscopically investigate the biomechanistic structure relationship and therapeutic effects of the Nordihydroguaiaretic Acid (NDGA) chemical derived from the Larrea Tridentata plant. These relationships are crucial for understanding NDGA's efficacy in disease prevention, treatment, and potential toxicological effects. While the medicinal and antiviral properties of the NDGA have been studied extensively, there remains a gap in optically identifying and reporting its structural changes. The current research successfully reveals evident trends in NDGA's vibrational signatures, particularly highlighting the absence of the Raman feature at 780 〖cm〗^(-1) as indicative of a fully …
Microwave Emission Model Parameter Tuning For Surface Soil Moisture Retrieval Using Uav-Mounted Dual Polarization L-Band Radiometer, Santiago Hoyos Echeverri
Microwave Emission Model Parameter Tuning For Surface Soil Moisture Retrieval Using Uav-Mounted Dual Polarization L-Band Radiometer, Santiago Hoyos Echeverri
Open Access Theses & Dissertations
Surface soil moisture retrieval from L-band brightness temperature has been developed for the past decades due to multiple beneficial characteristics of 1-2 GHz frequency bands for remote sensing of the environment. Numerous microwave emission models have been proposed for tower and satellite-based operations with successful retrieval of surface soil moisture and vegetation water content. As a result of the development of cost-effective and low-mass microwave L-band radiometers such as the Portable L-band Radiometer (PoLRa), surface soil moisture surveying traditionally developed by satellite missions SMOS and SMAP can now be developed at local scales, bringing these operations to commercial small unmanned …
Synthesis Of Neoglycoproteins As Potential Biomarkers For Chagas Disease And Cutaneous Leishmaniasis Caused By Leishmania (Viannia) Braziliensis, Eileni Rodriguez Gil
Synthesis Of Neoglycoproteins As Potential Biomarkers For Chagas Disease And Cutaneous Leishmaniasis Caused By Leishmania (Viannia) Braziliensis, Eileni Rodriguez Gil
Open Access Theses & Dissertations
Protozoan parasites are responsible for causing numerous diseases in humans and mammals worldwide. Among them are Chagas disease (CD), caused by the parasite Trypanosoma cruzi (T. cruzi), and tegumentary leishmaniasis (TL), caused by the parasite Leishmania (Viannia). Both diseases coexist in many regions of Latin America, and current hurdles to differentially diagnose them and determine chemotherapy success need to be overcome. CD can be diagnosed by traditional serological tests and polymerase chain reaction (PCR), but disadvantages of these methods are that they may produce false negatives because the antigens used in commercial CD kits are not conserved across all T.cruzi …
Characterizing The Mentoring Landscape In An Online Biology Cure: An Examination Of Student And Graduate Teaching Assistant Perspectives And Outcomes, Karen Alejandra Santillan
Characterizing The Mentoring Landscape In An Online Biology Cure: An Examination Of Student And Graduate Teaching Assistant Perspectives And Outcomes, Karen Alejandra Santillan
Open Access Theses & Dissertations
Both undergraduate research experiences (UREs) and course-based undergraduate research experiences (CUREs) provide students with benefits and opportunities such as improving technical skills and making connections that provide resources. Where these two experiences differ is accessibility. Similar to their URE counterpart, CUREs entail mentorship on the part of the faculty/graduate teaching assistant (GTA) instructor (Dolan, 2016). There is general agreement that mentoring has many benefits for undergraduate STEM students, such as an improvement in retention rates, increased confidence and self-efficacy, and a more established sense of belonging and science identity (Dolan, 2016). CURE instructors often adopt the role of “mentor” in …
Atlas-Based Analysis Of The Neural Projections From The Lateral Hypothalamic Area To The Lower Brainstem In The Adult Male Rat, Jessica Valeria Salcido Padilla
Atlas-Based Analysis Of The Neural Projections From The Lateral Hypothalamic Area To The Lower Brainstem In The Adult Male Rat, Jessica Valeria Salcido Padilla
Open Access Theses & Dissertations
Within the last decade, the number of diseases associated with dysregulation of the neural circuits responsible for energy balance, glucosensing, and feeding control has increased. One brain region containing these circuits is the lateral hypothalamic area (LHA), which plays an important role in the sleep/wake cycle, energy balance, and motivated behavior. Although the LHA has been termed a â??feeding centerâ??, other regions within the hindbrain are known for the regulation of similar functions including energy balance, glucosensing, and feeding control. While many studies have explored and reported projections from the LHA to the hindbrain, few have further investigated the interconnections …
Agricultural Groundcover Update March 2024, Justin Laycock
Agricultural Groundcover Update March 2024, Justin Laycock
Natural resources published reports
- In March, over 10% (1,577,000 ha) of the arable farmland in the south-west of Western Australia had less than 50% vegetative groundcover, which is inadequate to prevent wind erosion.
- The northern grainbelt had the highest risk of wind erosion and over 20% of this farmland had inadequate groundcover.
- About 1.3% (191,000 ha) of arable land had a high to very high risk of wind erosion because groundcover was less than 30%.
Fighting For A Health Diagnosis: An Autoethnographic Journey Into The Role Of Access And Limitations Of Resilience In The Face Of Poverty, Josette Pelatan
Fighting For A Health Diagnosis: An Autoethnographic Journey Into The Role Of Access And Limitations Of Resilience In The Face Of Poverty, Josette Pelatan
Open Access Theses & Dissertations
This research represents a highly personalized account of the complexities, interpretations, and reflections of the journey of a doctoral student navigating the challenges of health through access on a U.S.-Mexico border. Using myself as the subject and the researcher in the social context of schooling provided the impetus for this self-study. Through an insider’s vantage point, I have chronicled and traced the experiences of my own identities’ transitions and multilayered intersectionality using the qualitative methodology of autoethnography. This genre of qualitative research brings the reader closer to the subculture studied through the author’s experiences.
While every story has its unique …
High Intraspecific Diversity Of Pocillopora Damicornis In Southeast Asia Reflects Adaptive Potential To Climate Change, Maria Lucille Carr
High Intraspecific Diversity Of Pocillopora Damicornis In Southeast Asia Reflects Adaptive Potential To Climate Change, Maria Lucille Carr
Theses and Dissertations
Marine heatwaves are increasing in intensity and frequency because of increased emissions of greenhouse gases. On coral reefs, warmer temperatures cause coral bleaching, mortality, and shifts in benthic composition. However, coral bleaching responses and survival vary geographically. Several hypotheses may explain such geographical differences in thermal tolerance, including the possibility that some localities may support higher intraspecific diversity than other localities, increasing the likelihood of survival of some individuals through heatwaves. Here we assessed geographic patterns of intraspecific genetic diversity in the ubiquitous coral Pocillopora damicornis. Intraspecific genetic diversity was assessed for 428 sequences across 44 sites in the Pacific …
Effects Of Nicotinamide Riboside In Ovo Feeding On High-Yield Broiler Performance, Meat Quality, And Myopathy Incidence, Clay J. Maynard, John M. Gonzalez, Taketo Haginouchi, Olivia G. Ellis, Ashunti R. Jackson, Casey M. Owens
Effects Of Nicotinamide Riboside In Ovo Feeding On High-Yield Broiler Performance, Meat Quality, And Myopathy Incidence, Clay J. Maynard, John M. Gonzalez, Taketo Haginouchi, Olivia G. Ellis, Ashunti R. Jackson, Casey M. Owens
Poultry Science Faculty Publications and Presentations
Introduction: The objective of this study was to examine the effects of in ovo nicotinamide riboside (NR) feeding on high-yield broiler growth and meat quality.
Methods: Fertilized Cobb 700 by-product eggs (N = 3,240) were randomly assigned to one of four in ovo treatments and injected with 0 (0NR), 250 (250NR), 500 (500NR), or 1,000 (1,000NR) mM NR at incubation-day 10. Chicks were hatched, vent sexed, and randomly placed 18 per pen in one of 32 floor pens. On day 48, birds were processed and deboned.
Results: There were dose effects …
Effects Of Blood Flow Restriction During Acute Multi-Joint Eccentric Exercise On Muscle Recovery, Cody Fisher
Effects Of Blood Flow Restriction During Acute Multi-Joint Eccentric Exercise On Muscle Recovery, Cody Fisher
All Graduate Reports and Creative Projects, Fall 2023 to Present
Blood flow restriction (BFR) exercise has become an increasingly common modality due to evidence that it may yield positive muscle-related effects from low-intensity exercise. However, eccentric-only exercise in a multi-joint format has not yet been investigated in regard to the BFR influence on muscle recovery characteristics. The purpose of this study was to assess muscle recovery responses via isometric peak force (PF), soreness (i.e., VAS, PPT, PPD), and functional power (i.e., SLHD) following a 5-minute low-load multi-joint eccentric exercise bout with or without blood flow restriction. Thirty participants were randomly assigned into either an eccentric-only (CON) or an eccentric BFR …
Soil Reclamation Strategies In Construction Disturbed Soil, Alexis Koelling
Soil Reclamation Strategies In Construction Disturbed Soil, Alexis Koelling
All Graduate Reports and Creative Projects, Fall 2023 to Present
The rapid urbanization occurring in arid environments like the Intermountain West region of the U.S. significantly alters soil conditions. Construction of roads, buildings, and other infrastructure leads to the disturbance of soil structure, nutrient depletion, and reduced fertility. This research addresses the need for sustainable soil management practices that may restore soil health post-construction. In this study, the effectiveness of various soil amendments and application methods on specific soil parameters and turfgrass establishment in construction-disturbed soils was evaluated. The study highlights the critical role of soil amendments, particularly municipal solid waste (MSW) compost, in improving soil quality and plant growth. …
A Micro-Perspective Analysis Of The Demand For Greek And Non-Greek Yogurt In The United States Over Calendar Years 2018 To 2020, Oral Capps, Riuxin Jia, Vikas Mishra, Macson O. Ogieriakhi
A Micro-Perspective Analysis Of The Demand For Greek And Non-Greek Yogurt In The United States Over Calendar Years 2018 To 2020, Oral Capps, Riuxin Jia, Vikas Mishra, Macson O. Ogieriakhi
Agricultural Economics and Agribusiness Faculty Publications and Presentations
Using the Heckman framework, we develop profiles of households who purchase Greek yogurt and non-Greek yogurt and estimate own-price, cross-price, and income elasticities of demand. Attention is centered on the impacts of age, race, education, and ethnicity of the household head, household income, household size, region, the presence of children, and prices of Greek yogurt and non-Greek yogurt. This analysis rests on data acquired from Nielsen pertaining to 164,484 households over calendar years 2018–2020. Own-price elasticities are estimated to be −1.36 for Greek yogurt and −0.70 for non-Greek yogurt. Additionally, these yogurt products are not only substitutes but also necessities.
Utilizing Nanodiamond For Antiretroviral Drug Delivery To Hiv Infected Microglial Cells, Ebenezer Owusu
Utilizing Nanodiamond For Antiretroviral Drug Delivery To Hiv Infected Microglial Cells, Ebenezer Owusu
Theses and Dissertations
Combination antiretroviral therapy (cART) is widely used to treat HIV infection, but it fails to eradicate viral reservoirs, such as microglia in the brain, leading to HIV-associated neurological disorders (HAND). Advances in nanomedicine have enabled the development of targeted drug delivery systems, and nanodiamonds (NDs) and fluorescent nanodiamonds (FNDs) have emerged as a potential solution due to their biocompatibility, non-toxic nature, and efficiency as drug carriers. Our study builds on previous findings that NDs can cross the blood-brain barrier (BBB), aiming to utilize NDs and FNDs for their added traceability. We propose a multifunctional nanodrug platform that leverages NDs and …
Deoxynivalenol And Fumonisin Predispose Broilers To Bacterial Chondronecrosis With Osteomyelitis Lameness, Khawla Alharbi, Nnamdi Ekesi, Amer Hasan, Andi Asnayanti, Jundi Liu, Raj Murugesan, Shelby Ramirez, Samuel Rochell, Michael T. Kidd, Adnan Alrubaye
Deoxynivalenol And Fumonisin Predispose Broilers To Bacterial Chondronecrosis With Osteomyelitis Lameness, Khawla Alharbi, Nnamdi Ekesi, Amer Hasan, Andi Asnayanti, Jundi Liu, Raj Murugesan, Shelby Ramirez, Samuel Rochell, Michael T. Kidd, Adnan Alrubaye
Poultry Science Faculty Publications and Presentations
Bacterial chondronecrosis with osteomyelitis (BCO) lameness is the most critical animal health and welfare issue facing the broiler industry worldwide. It is estimated that 1 to 2% of bird condemnation at marketing age is caused by BCO lameness, resulting in tens of millions of dollars in annual losses. Fast-growing broilers are prone to mechanical stress that triggers bacterial translocation across epithelial barriers into the bloodstream, followed by bacterial colonization in the growth plate of long bones, and eventually, bone necrosis and lameness. Mycotoxins (MTX) are secondary metabolites produced naturally by microfungi, of which deoxynivalenol (DON …
Potential Consumer Response To The Healthy Symbol Proposed By The Us Food And Drug Administration, Jillian Hyink, Brandon R. Mcfadden, Brenna Ellison
Potential Consumer Response To The Healthy Symbol Proposed By The Us Food And Drug Administration, Jillian Hyink, Brandon R. Mcfadden, Brenna Ellison
Agricultural Economics and Agribusiness Faculty Publications and Presentations
The U.S. Food and Drug Administration (FDA) has proposed updates to the definition of “healthy,” including distinctions between types of sugar and fats and limits on added sugar, saturated fat, and sodium. To communicate the updated standards, the FDA is developing a Healthy symbol to display on food packages, which could reduce knowledge gaps by assisting U.S. consumers in meeting recommended nutritional guidelines. This study aimed to explore the potential for the label to increase consumers' ability to correctly identify a food product that met the FDA's criteria for a healthy symbol. To complete the study objective, 1018 adults were …
Exploring The Impact Of Subject Placement On Exam Questions, Briana M. Craig, Jeremy L. Hsu
Exploring The Impact Of Subject Placement On Exam Questions, Briana M. Craig, Jeremy L. Hsu
Student Scholar Symposium Abstracts and Posters
Quizzes and exams are crucial elements of undergraduate biology courses; however, little research has been done exploring the importance of the phrasing used in the questions on these assessments. Question framing has the potential to impact student performance and sense of belonging greatly. In this study, we conducted an experiment where we created three versions of the exact same question except for the framing for the experimental scenarios. One version was written with self-referential framing using the term “you,” simulating the student conducting the experiment; another version used classmate-referential framing, placing one of their peers in the experiment; the third …
The Impact Of Differing Instability Devices On Postural Sway Parameters, Kacey Wallace
The Impact Of Differing Instability Devices On Postural Sway Parameters, Kacey Wallace
Honors Theses
Single-limb balance training is an integral part of preventing and rehabilitating lower extremity injuries. Practitioners use instability devices to provide a progressive overload to an individual during single-limb balance training sessions. Previous investigations have shown that when using instability devices, differences may or may not exist in postural sway parameters during use depending on the specific devices being assessed. Thus, this investigation sought to examine differences between a commonly used foam pad and a novel instability device (block) in measures of postural sway.
This experiment consisted of 22 healthy individuals with no history of lower extremity injury and neurological disorders. …
The Effects Of Prescribed Fire On Microbial Biomass Abundance In Longleaf Pine Ecosystems, Sarah K. Borne
The Effects Of Prescribed Fire On Microbial Biomass Abundance In Longleaf Pine Ecosystems, Sarah K. Borne
Honors Theses
One of the most diverse ecosystems, longleaf pine (Pinus palustris) habitats comprise only a small fraction of the habitat they once spanned in the Gulf Coastal Plain Region of the Southeastern United States. To preserve longleaf pine ecosystems, proper prescribed burning techniques and ecosystem management are essential for preventing high intensity wildfires and increasing species diversity. Little is known about the effects of prescribed fires on carbon levels, nitrogen levels, and microbial biomass in longleaf pine forests. These components are crucial for determining how well burned areas are recovering at a microbial level compared to unburned areas. The …
The Effects That Dietary Intake And Cardiorespiratory Fitness Has On Insulin Resistance In Adults, Trinady Moore
The Effects That Dietary Intake And Cardiorespiratory Fitness Has On Insulin Resistance In Adults, Trinady Moore
Honors Theses
Insulin resistance can impair bodily responses to insulin and the uptake of glucose within the human body. This imparity has many consequences and can more commonly cause Type II Diabetes.1 This study focuses on how different lifestyle modifications can be used to combat the sensitivity to insulin within the body. The sample included forty-one adults whose ages varied from 18 to 35 years old. The participants completed a VO2max test, blood glucose test, and a 31- item food frequency survey. These tests and survey questions revealed the correction between the participants’ age, blood glucose levels, VO2max score, and diet …
Mate Choice Between Two Species Of Topminnows From Dissimilar Hybrid Zones, Chloe Davis
Mate Choice Between Two Species Of Topminnows From Dissimilar Hybrid Zones, Chloe Davis
Honors Theses
Understanding the origins of reproductive isolation between closely related species is foundational to evolutionary and ecological research. Recent reviews have documented contemporary hybridization between a large portion of species. A greater knowledge of reproductive isolation and its components are vital to expanding conservation efforts for threats such as those to species persistence and community processes. However, there is a lack of clear understanding of how isolating mechanisms evolve throughout many systems where hybridization is prominent. Individuals within the Fundulus notatus species complex (F. notatus, F. olivaceus, and F. euryzonus) readily hybridize at many contact zones replicated throughout their …
Models Of Functional Redundancy In Ecological Communities, Sandra Annie Tsiorintsoa
Models Of Functional Redundancy In Ecological Communities, Sandra Annie Tsiorintsoa
All Dissertations
Functional redundancy is the number of taxa that perform a given function within a given community. In most systems, high levels of functional redundancy are important, because they contribute to ecosystem stability. However, we currently have very little understanding of why functional redundancy varies among communities. One possible factor that could affect functional redundancy is environmental complexity. Many studies show that simplified ecosystems harbor communities with lower taxon diversity. What is less clear is if this simplicity and lower taxon diversity also affects functional redundancy. To answer this question, we use metacommunity models to explore the connection between environmental complexity …
Mesenchymal Stromal Cell Response To Degenerated Intervertebral Disc-Like Ph, Kyle Cannon
Mesenchymal Stromal Cell Response To Degenerated Intervertebral Disc-Like Ph, Kyle Cannon
All Dissertations
Intervertebral disc degeneration (IVDD) has become increasingly prevalent and is a common contributing factor to low back pain. There are currently no clinical treatment options for IVDD that alleviate the symptoms of IVDD while simultaneously promoting repair of IVD tissue. One treatment option being explored is intradiscal administration of mesenchymal stromal cells (MSCs). However, the microenvironment of the degenerating IVD places significant stress on both native IVD cells and implanted cells. There are several questions that need to be addressed which may help further inform the development of efficacious intradiscal MSC therapies for IVDD. These questions include: 1) Do MSCs …