Life Sciences Commons^™

The Impact Of Estradiol And/Or Trenbolone Acetate On The Metabolome And Skeletal Muscle Metabolism Of Beef Cattle, Kara J. Thornton-Kurth

Funded Research Records

No abstract provided.

Determining The Interrelationships For Dietary Intake Of Lipid Oxidation Products From Thermally Abused Oils, The Gut Microbiome, And Gut Health, Abby Benninghoff

Funded Research Records

No abstract provided.

Animal Breeding-Rcn: Farm Animal Genomics Collective, Noelle E. Cockett

Funded Research Records

No abstract provided.

Novel Hamster Models Of Chikungunya Viral Arthritis, Tian Wang, Zhongde Wang

Funded Research Records

No abstract provided.

Designing A Novel Approach To Cadaveric Dissection And Evaluation Of The Lacrimal Gland Anatomy, Maresa Joanna Mcdowell

Doctoral Dissertations and Projects

During our study, the orbital dissections of 44 cadavers were analyzed, and the lacrimal gland's condition after dissection was evaluated. Medical students previously dissected twenty-two of the cadavers using the dissection steps outlined in Grant’s Dissector. From these, 21 student groups performed orbital dissection using the two approaches outlined in Grant’s Dissector. Post-evaluation of Grant’s anterior approach (GAA) showed that 50% of the lacrimal glands had signs of damage to the orbital lobe, and 88.89% of the palpebral lobe were damaged. When Grant’s supraorbital approach (GSA) was used, 70% of the palpebral lobes showed signs of damage compared to the …

Physiological And Psychological Performance Considerations Of Female Elite Warfighters (Few) In United States Military Special Operations: A Qualitative Study, Bailey Weis

Doctoral Dissertations and Projects

The purpose of this qualitative study was to better understand the physical and psychological characteristics of the female elite warfighters (FEW) that have completed a special operations selection or elite combat course in the United States Armed Forces. The theory guiding this study was Kathy Charmaz’s constructivist grounded theory (CGT) to gain deeper insight on the female pioneers who are completing special operations selections or elite combat courses by exploring the physical and psychological nature of their experience. The CGT framework for this study highlighted the participants’ background, physical insights, and mental resilience as indicators of their success while enabling …

The Effects Of Intermittent Fasting On Working Memory With A Covariate Of Exercise Among The Perimenopausal Population: A Randomized Controlled Trial, Karen Marie Veltri

Doctoral Dissertations and Projects

Intermittent fasting and exercise are tools to improve health. Current literature focuses on their impact on metabolic health and weight loss, leaving a gap in the research examining their effects on working memory during the menopause transition. The purpose of this study was to address this gap by recruiting perimenopausal participants and randomly assigning them to an experimental or a control group. The experimental group followed an 8/16 intermittent fasting regimen for two consecutive weeks. Both groups ate ad libitum without dietary restrictions. Participants completed a pre- and post-study Working Memory Questionnaire and self-reported average hours of exercise per week. …

High Workload Effects On Patient Satisfaction And Profitability Of Nursing Homes, Richard Ra Alrayes

Doctoral Dissertations and Projects

The main issue focused on in the research is that increased workload experienced by employees in nursing homes in Houston, TX creates an increase in medical errors and results in the loss of customer satisfaction and profitability to the business. To address the problem, convergent parallel mixed methods were used to understand the effect of high workload on patient satisfaction and the profitability of nursing homes in Houston, Texas. The mixed methods study was guided by four research questions: (1) How does increased workload experienced by employees in nursing homes impact the quality of provided healthcare services? (2) How does …

Effect Of Cytoplasmic Polyadenylation Element Protein Overexpression On The Development Of Bovine Cloned Embryos, Ying Liu

Funded Research Records

No abstract provided.

Effects Of The Western Diet And Psychological Stress On Gut Health, Korry J. Hintze

Funded Research Records

No abstract provided.

Building Resilience: Incentivizing Agricultural Water Conservation In Utah Amid Climate Uncertainty And Prior Appropriation Water Rights, Man Li

Funded Research Records

No abstract provided.

Rethinking Pregnancy Recognition In Ruminants: Pregnancy Recognition In Ewes Lacking Interferon-Tau Signaling, Chris Davies

Funded Research Records

No abstract provided.

Investigation Of The Endogenous Opioid Neural Circuitry In Pain, Erin Nicole Bobeck

Funded Research Records

No abstract provided.

A Qualitative Examination Of Food Choice Among Division Iii Student Athletes Using Grounded Theory, Paul Webster Craig

Doctoral Dissertations and Projects

The determinants of food choice among the general population have been extensively investigated, but studies of food choice in collegiate student athletes are limited. Student athletes make food choices daily, and the selection of foods is an integral part of an athlete’s training regimen. National Collegiate Athletic Association (NCAA) Division III (DIII) student athletes are a comparatively unstudied population, particularly in terms of their food choices; therefore, assessing and understanding the influences of food choices in this population can enable and support optimal eating behavior. To assess different determinants of food choice in athletes, this qualitative study developed a theoretical …

Remote Sensing Detection Of Growing Season Freeze-Induced Defoliation Of Montane Quaking Aspen (Populus Tremuloides) In Southern Utah, Usa, Timothy E. Wright, Yoshimitsu Chikamoto, Joseph D. Birch, James A. Lutz

Plants, Soils and Climate Student Research

Growing season freeze events pose a threat to quaking aspen (Populus tremuloides Michx.), leading to canopy defoliation, reduced vigor, and increased mortality, especially for declining montane populations western North America. Detecting the spatial distribution and progression of this damage is challenging due to limited in situ observations in this region. This study represents the first attempt to comprehensively resolve the spatial extent of freeze-induced aspen canopy damage in southern Utah using multispectral remote sensing data. We developed an approach to detect the spatial and temporal dynamics of freeze-damaged aspen stands, focusing on a freeze event from 8-9 June 2020 …

Food Safety Research And Extension Needs For The U.S. Low-Moisture Food Industry, Han Chen, Nathan M. Anderson, Elizabeth M. Grasso-Kelley, Linda J. Harris, Bradley P. Marks, Lindsey Mcgowan, Robert L. Sharff, Jeyamkondan Subbiah, Juming Tang, Felicia Wu, Yaohua Feng

Food Science Faculty Publications and Presentations

Historically, low-moisture foods were considered to have minimal microbial risks. However, they have been linked to many high-profile multistate outbreaks and recalls in recent years, drawing research and extension attention to low-moisture food safety. Limited studies have assessed the food safety research and extension needs for the low-moisture food industry. The objectives of this needs assessment were to explore the food safety culture and education needs, identify the food safety challenges and data gaps, and understand the barriers to adopting food-safety-enhancing technologies in the U.S. low-moisture food industry. This needs assessment was composed of two studies. In Study 1, food …

Target Consumers For Locally Grown Fruit In Utah, Kynda R. Curtis, Makaylie Langford, Tammy King

All Current Publications

This fact sheet describes target consumers for locally grown fruits and fruit products in Utah. The data examined here comes from an online survey (via Qualtrics) of Utah consumers conducted in 2023. Here, we compare consumers who are willing to pay a higher premium for local fruit products and those who are not, outlining the distinction between them in terms of their demographics, purchasing patterns and shopping habits, as well as their lifestyle and attitudes.

Target Consumers For Organically Grown Fruit In Utah, Kynda R. Curtis, Makaylie Langford, Tammy King

All Current Publications

This fact sheet provides an overview of target consumers for organically grown fruits and fruit products in Utah. The data examined here comes from an online survey (via Qualtrics) of Utah consumers conducted in 2023. Here, we compare those willing to pay premiums for organically grown fruit and those unwilling to do so, outlining the distinction between them in terms of their demographics, purchasing patterns and shopping habits, as well as their lifestyle and attitudes.

Predicting Mutation-Induced Allosteric Changes In Structures And Conformational Ensembles Of The Abl Kinase Using Alphafold2 Adaptations With Alanine Sequence Scanning, Nishank Raisinghani, Mohammed Alshahrani, Grace Gupta, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

Despite the success of AlphaFold2 approaches in predicting single protein structures, these methods showed intrinsic limitations in predicting multiple functional conformations of allosteric proteins and have been challenged to accurately capture the effects of single point mutations that induced significant structural changes. We examined several implementations of AlphaFold2 methods to predict conformational ensembles for state-switching mutants of the ABL kinase. The results revealed that a combination of randomized alanine sequence masking with shallow multiple sequence alignment subsampling can significantly expand the conformational diversity of the predicted structural ensembles and capture shifts in populations of the active and inactive ABL states. …

Humoral Immunity And Antibody Responses Against Diphtheria, Tetanus, And Pneumococcus After Immune Effector Cell Therapies: A Prospective Study, Georgios Angelidakis, Roy F Chemaly, Pranoti V Sahasrabhojane, Oscar Morado-Aramburo, Ying Jiang, Elizabeth Shpall, Preetesh Jain, Kris Michael Mahadeo, Fareed Khawaja, Peter Elhajj, Jennifer A Wargo, Robert R Jenq, Nadim J Ajami, Partow Kebriaei, Ella J Ariza-Heredia

Faculty, Staff and Student Publications

Patients undergoing immune effector cell therapy (IECT) are at high risk for infections. We assessed seropositivity against pneumococcus, tetanus, and diphtheria in patients before and after IECT and the patients' response to vaccination. We enrolled patients who underwent IECT from January 2020 to March 2022. Antibody levels for diphtheria, tetanus, and pneumococcus were measured before IECT, at 1 month, and 3-6 months after. Eligible patients were vaccinated after IECT. In non-seroprotected patients, we discontinued testing. Before IECT, most patients had seroprotective antibody levels against tetanus (68/69, 99%) and diphtheria (65/69, 94%), but fewer did against pneumococcus (24/67, 36%). After IECT, …

Production Of Genetically Stable And Odontoglossum Ringspot Virus-Free Cymbidium Orchid ‘New True’ Plants Via Meristem-Derived Protocorm-Like Body (Plb) Subcultures, Jova Riza Campol, Aung Htay Naing, Hay Mon Aung, Su Bin Cho, Hyunhee Kang, Chang Kil Kim

Faculty, Staff and Student Publications

BACKGROUND: This study aimed to produce Odontoglossum ringspot virus (ORSV)-free Cymbidium orchid 'New True' plants from ORSV-infected mother plants by culturing their meristems and successively repeating subcultures of protocorm-like bodies (PLBs) derived from the meristems.

RESULTS: Initially, ORSV was confirmed as the causative agent of viral symptoms in orchid leaves via reverse transcription-polymerase chain reaction (RT-PCR) analysis. Meristems from infected plants were cultured to generate PLBs, which in sequence were repeatedly subcultured up to four times. RT-PCR and quantitative RT-PCR analyses revealed that while ORSV was undetectable in shoots derived from the first subculture, complete elimination of the virus required …

Current Status And Research Directions In Acute Myeloid Leukemia, Hagop Kantarjian, Gautam Borthakur, Naval Daver, Courtney D Dinardo, Ghayas Issa, Tapan Kadia, Nicholas J Short, Musa Yilmaz, Farhad Ravandi

Faculty, Staff and Student Publications

The understanding of the molecular pathobiology of acute myeloid leukemia (AML) has spurred the identification of therapeutic targets and the development of corresponding novel targeted therapies. Since 2017, twelve agents have been approved for the treatment of AML subsets: the BCL2 inhibitor venetoclax; the CD33 antibody drug conjugate gemtuzumab ozogamicin; three FLT3 inhibitors (midostaurin, gilteritinib, quizartinib); three IDH inhibitors (ivosidenib and olutasidenib targeting IDH1 mutations; enasidenib targeting IDH2 mutations); two oral hypomethylating agents (oral poorly absorbable azacitidine; fully absorbable decitabine-cedazuridine [latter approved as an alternative to parenteral hypomethylating agents in myelodysplastic syndrome and chronic myelomonocytic leukemia but commonly used in …

The P-Myh9/Usp22/Hif-1Α Axis Promotes Lenvatinib Resistance And Cancer Stemness In Hepatocellular Carcinoma, Qiaonan Shan, Lu Yin, Qifan Zhan, Jiongjie Yu, Sheng Pan, Wei Zhou, Lincheng Zhang, Jiachen Hong, Jianan Xiang, Qingyang Que, Kangchen Chen, Shengjun Xu, Jingrui Wang, Yangbo Zhu, Bin He, Jingbang Wu, Haiyang Xie, Shusen Zheng, Tingting Feng, Sunbin Ling, Xiao Xu

Faculty, Staff and Student Publications

Lenvatinib is a targeted drug used for first-line treatment of hepatocellular carcinoma (HCC). A deeper insight into the resistance mechanism of HCC against lenvatinib is urgently needed. In this study, we aimed to dissect the underlying mechanism of lenvatinib resistance (LR) and provide effective treatment strategies. We established an HCC model of acquired LR. Cell counting, migration, self-renewal ability, chemoresistance and expression of stemness genes were used to detect the stemness of HCC cells. Molecular and biochemical strategies such as RNA-sequencing, immunoprecipitation, mass spectrometry and ubiquitination assays were used to explore the underlying mechanisms. Patient-derived HCC models and HCC samples …

The Role Of Media Education Courses In Developing The Skills Of Dealing With Digital Information And News Verification Among Teachers Of The Jordanian Ministry Of Education, Amjad Omar Safori, Ibrahim Jamal Sorri

The study sought to determine the role of media and information education courses provided by the Jordan Media Institute in developing the skills of teachers of the Jordanian Ministry of Education in dealing with digital information and news verification in Jordan, by using the public survey approach using the questionnaire tool on a deliberate sample of (316) teachers who participated. In training courses. The study concluded that the percentage of implementation of specialized activities and training in the field of media education increased by approximately 25% as aresult of teachers’ participation in specialized courses in this regard. The results indicated …

Synthesis Of Zno: Zro2 Nanocomposites Using Green Method For Medical Applications, Mohammed J. Tuama, Maysoon F. Alias

Karbala International Journal of Modern Science

These days, nanocomposites are very popular, especially in medical applications. The spread of diseases in general, and those caused by microbes and cancerous diseases in particular, and the increased resistance of these diseases to antibiotics, have led to the need for the rapid, low-cost, and environmentally friendly production of nanocomposites. To create the chemical G-ZnO: ZrO2 and S-ZnO: ZrO2 (green technique), two different plant extracts were utilized: Z. officinal and S. aromaticum. The effective synthesis and acceptable properties features of the nanoparticles were confirmed using characterization techniques such as X-ray diffraction (XRD), Fourier transform infrared (FTIR) , diffuse reflectance spectroscopy …

Deciphering Evolutionary Co-Option By Studying The Origin Of Self-Fertility In Caenorhabditis Nematodes, Jonathan P. Harbin

Theses and Dissertations

In my research, I examined the characteristics of male and female sex-determination mutants in C. nigoni and investigated the regulatory pathway they define. This work tested whether flexibility in the sex-determination pathway was a preexisting condition that favored the origin of self-fertility in Caenorhabditis. Furthermore, I developed an approach for using interspecies hybrid mutants to assess the robustness of the C. nigoni pathway. My findings showed that the C. nigoni pathway is highly robust and canalized, suggesting that changes leading to self-fertility must have involved the impairment of this canalization in the germ line, to allow eventual alteration of germ …

Synaptotagmin-9 In Mouse Retina, Chris S. Mesnard, Cassandra L. Hays, Lou E. Townsend, Cody L. Barta, Channabasavaiah B. Gurumurthy, Wallace B. Whoreson

Neuroscience Faculty Publications

Synaptotagmin-9 (Syt9) is a Ca2+ sensor mediating fast synaptic release expressed in various parts of the brain. The presence and role of Syt9 in retina is unknown. We found evidence for Syt9 expression throughout the retina and created mice to conditionally eliminate Syt9 in a cre-dependent manner. We crossed Syt9fl/fl mice with Rho-iCre, HRGP-Cre, and CMV-Cre mice to generate mice in which Syt9 was eliminated from rods (rodSyt9CKO), cones (coneSyt9CKO), or whole animals (CMVSyt9). CMVSyt9 mice showed an increase in scotopic electroretinogram (ERG) b-waves evoked by bright flashes with no change in a-waves. Cone-driven photopic ERG b-waves were not significantly …

Aging Drives Cd8 T Cells To Functional Extremes: From Non-Specific Cytotoxicity To Tissue-Mediated Exhaustion, Irina Shchukina

Arts & Sciences Graduate Student Theses and Dissertations

CD8 T cells are a crucial component of the immune system, primarily responsible for executing the effector response against viral infections and cancer. Aging significantly impacts most immune cell types, with particularly dramatic changes observed in CD8 T cells. One major age-related difference is the marked decline in thymus activity, which leads to a substantial reduction in naive CD8 T cells and an increased abundance of memory CD8 T cells. Furthermore, recent work from our lab demonstrated that while young memory CD8 T cells are relatively homogeneous, memory CD8 T cells diverge into two subpopulations: PD1- memory CD8 T cells …

Oregon State Rank Assessment For Columbia Mottled Sculpin (Cottus Hubbsi), Eleanor P. Gaines

Institute for Natural Resources Publications

Oregon state conservation status assessment for Columbia mottled sculpin (Cottus hubbsi) using NatureServe methodology, 2024.

Oregon State Rank Assessment For Goose Lake Lamprey (Entosphenus Tridentatus Ssp. 1), Eleanor P. Gaines

Institute for Natural Resources Publications

Oregon state conservation status assessment for Goose Lake lamprey (Entosphenus tridentatus ssp. 1) using NatureServe methodology, 2024.