Life Sciences Commons^™

Therapeutic Approach Of Carbon Nanotube: Revolutionize Nanomaterial In Biomedical And Pharmaceutical Sector, Shovan Ghosh, Vivek Dave, Pranay Wal

Journal of Food and Drug Analysis

Carbon nanotubes (CNTs) has emerged as a promising nanomaterial with a wide range of potential applications due to their unique structural, mechanical, electrical, and thermal properties. However, numerous obstacles must be overcome for CNTs to be used successfully, including low solubility, aggregation, and a lack of specialized functions. Diverse techniques have been developed for the manufacture, purification, and functionalization of CNTs in order to overcome these issues. The main aim of this review article is to provide brief knowledge about CNTs and strategies to use this revolutionized nanomaterial in drug delivery. Prepare CNTs cannot be directly used as drug carrier …

Updates On The Conversion Of Nanosuspensions To Solid Oral Dosage Forms, Anastasia Tsiaxerli, Elisavet Vardaka, Christos Moutroupidis, Kevin M.G. Taylor, Kyriakos Kachrimanis, Maria Malamatari

Journal of Food and Drug Analysis

Pharmaceutical nanosuspensions, also called nanocrystals, are heterogeneous mainly aqueous dispersions of insoluble drug particles stabilised by surfactants and/or polymers. Nanosuspensions as liquid formulations suffer from instability. Solidification of nanosuspensions to solid dosage forms is a way to combine the advantages of nanocrystals with the advantages of the solid state. In this review, advances regarding stabilisation and production of nanosuspensions are briefly covered. Updates on the methods used to convert nanosuspensions to solid oral dosage forms (e.g., powder, granules, pellets, tablets, and films) are presented in depth. From these methods, spray drying and freeze drying are widely used. Granulation and hot-melt …

Mechanobactericidal Nanotopographies For Food Industry: A Promising Strategy For Eradicating Foodborne Pathogens - Progress And Challenges, Deepak Patil

Journal of Food and Drug Analysis

Nowadays, food preservation, quality maintenance, and safety are major emerging concerns in the food industry. Methods for removing pathogens from the outside surfaces of food products would be an effective way to prevent bacterial contamination. Nanotopographies found on natural surfaces have been shown to mechanically damage the membranes of foodborne bacteria. Thus, using bioinspired mechanobactericidal nanostructures in food packaging and processing materials has the potential to lower surface bacterial contamination while increasing food safety. However, putting this concept into practice remains a challenge. This review discussed recent advances in understanding mechanobactericidal mechanisms, issues concerning the durability of nanotopography under external …

A Mini Review Of Plant Tissue Culture: The Role Of Media Optimization, Growth Regulators In Modern Agriculture, Callus Induction And The Applications, Norrizah Jafaar Sidik, Hasan M. Agha, Abdulmutalib Alabeed Alkamil, Muneer Mohammed Saleh Alsayadi, Amjad Abdulhadi Mohammed

AUIQ Complementary Biological System

Plant tissue culture is an innovative biotechnological approach developed to meet the escalating global demand for agricultural production with enhanced nutritional value. This aseptic, in vitro technique allows for the cultivation of plant cells, tissues, or entire plants under controlled environmental and nutritional conditions, facilitating the generation of genetically identical clones. The method is indispensable in preserving endangered plant species, boosting crop yield and quality, and enabling year-round production of disease-free plants. Central to plant tissue culture is the composition of the growth medium, which must include a precise balance of macronutrients, micronutrients, amino acids, vitamins, and plant growth regulators …

Grip Strength As An Indicator Of Neuromuscular Recovery, Emily Wilhelm

Senior Honors Projects, 2020-current

Purpose: To evaluate whether grip strength accurately tracks recovery from lower-body exercise comparable to other physical tests and a blood biomarker. Methods: Six subjects (three males and three females) completed testing for estimated 1-RM, jump squat velocity, grip strength, creatine kinase and leg extension peak torque one day prior to a fatiguing session of 10 sets of squats for 10 repetitions at 60% of estimated 1-RM. Each of these tests, as well as ratings of muscular soreness were performed again 24, 48 and 72 hours after the session of squats. Results: For peak torque, the 24 hours (129.5± 35.0 …

The Effects Of Conspecific Stress Cues Caused By Harassment In The Mummichog (Fundulus Heteroclitus), Megan Quinn

Honors Theses

Many organisms, especially fish, participate in herding or schooling behaviors for various benefits such as increased survival rates, better hydrodynamic efficiency, or for hunting tactics. Due to being in a tightly packed group, disturbances or predation in their environment can result in group behavioral changes. Fish release hormones into surrounding water through excretions like urine because of a disturbance which may affect their surrounding conspecifics. In this experiment a lone mummichog (Fundulus heteroclitus) was exposed to a water sample from other conspecifics who were stressed through harassment. Physical behavioral changes such as changes in swimming activity, respiration rates and position …

Society Of American Foresters (Saf) Academic Publications As They Relate To The Curriculum Standards For Saf Forestry Program Accreditation: A Content Analysis, Lisa M. Bentley

Electronic Theses and Dissertations

Goals that impact decision-making components within academic programs in the university system have the potential to define and change the direction of a field of study, and, with that, should be thoughtfully approached with a certainty of evidence that supports responsible paradigms in forestry education. Periodic revision of the standards for accreditation by SAF influences institutional expectations that result in shifts in forestry education and should be consistent with professional forestry standards. The methodology utilized in this research contextualizes data from a sociological perspective intentionally as a method to holistically integrate data as evidence to support the interpretation of Society …

Naloxone Prescribing At Hospital Discharge: A Quality Improvement Initiative, Timothy Ford

Doctors of Nursing Practice (DNP) Final Projects, 2020-current

Opioid overdose deaths remain one of the largest public health challenges in the United States. Naloxone allocation is an important tool to help combat opioid overdose deaths. The literature supports that hospitalized patients are generally receptive to receiving naloxone and opioid education and interdisciplinary teams working together can help facilitate identification of high-risk patients for naloxone allocation. This quality improvement change, guided by the IHI Triple Aims and Model for Healthcare Improvement frameworks, sought to increase the rate of patients leaving the Hospital Medicine Service with naloxone. To accomplish this, during the target units’ daily interdisciplinary rounds, providers were prompted …

Conceptual Curiosity: Sense(Un)Making, Rebekah L. Cowell

Proceedings from the Document Academy

Across disciplines, sensemaking is a theoretical and methodological research program, over forty years in development, that has been treated as a framework for understanding how humans behaviorally respond to external information sources and interpret to construct and actualize actionable outcomes; however, sensemaking is an interlinking process that does not operate in singularity–behaviorally or actionably–it is neurobiological (autonomous drive), cognitive (perceptual and predictive), and psychological (congruency in meaning).

This paper enlarges the conceptual framework for studying sensemaking and redefines it by addressing what sensemaking is, does, and needs. At the core of this conversation is addressing the absence of knowledge and …

Early Host Defense Against Virus Infections, Søren R. Paludan, Thomas Pradeu, Andreas Pichlmair, K. Brad Wray, Jacob Giehm Mikkelsen, David Olagnier, Trine H. Mogensen

Presidential Fellows Articles and Research

Early host defense eliminates many viruses before infections are established while clearing others so they remain subclinical or cause only mild disease. The field of immunology has been shaped by broad concepts, including the pattern recognition theory that currently dominates innate immunology. Focusing on early host responses to virus infections, we analyze the literature to build a working hypothesis for the principles that govern the early line of cellular antiviral defense. Aiming to ultimately arrive at a criteria-based theory with strong explanatory power, we propose that both controlling infection and limiting inflammation are key drivers for the early cellular antiviral …

Cyperus Blepharoleptos Maxent Ecological Niche Models, Samuel A. Schmid, Maxwell G. Gebhart, Gray Turnage

GRI Publications

Invasive species are one of the foremost threats to global biodiversity and predicting where they can inhabit is of primary concern for researchers and resource managers. Ecological niche models (ENMs) are a useful tool for addressing this problem. This study focuses on Cyperus blepharoleptos (Cuban bulrush), an aquatic sedge that is invasive in the southeastern United States. To model the ecological niche of C. blepharoleptos, 1,137 records were compiled from North and South America and partitioned into training and testing data. Five BioClim variables (BIO1, BIO7, BIO12, BIO14, and BIO15) were selected as environmental variables for modeling. Using Maxent, 12 …

Are There Neurological Impacts Of Exposure To A Burned Wildfire Site As It Recovers?, Rubye Strickland

Undergraduate Honors Theses

Wildfires are increasing with climate change, making the human health implications of exposure to burned soils an essential area of research. Metals associated with fire-impacted soils can be inhaled or accidentally ingested by surrounding communities, causing health risks. Several studies have evaluated the health impact of wildfires, but few have done so from a neurological perspective. This study explores metal changes in burned soils over time as a site naturally recovers from wildfire and how these changes may impact human neurological health. Soil samples were collected from the burned area 0, 3, 6, 9, and 12 months after the fire. …

Food Security And Its Impact On Hypertension In Urban Communities, Lauren M. Nobriga

Master's Projects and Capstones

The Quality Improvement Team proposed an intervention to increase enrollment in the Food Security Program, a six-month initiative that provides vouchers redeemable for fruits and vegetables. Long-term impacts of this Program include an improved food economy and enhanced patient disease management autonomy. This project aimed to increase the percentage of eligible adult medicine clinic patients enrolled in the Food Security Program by 25%, or 11 patients per month, based on the mean enrollment for the first four months of the Program (May to August) of nine patients. The intervention was based on bi-monthly performance reports, making the goal include enrolling …

Effects Of Microbial Lipases On Parmesan And Feta Cheese Flavor Profiles, Erin N. Caswell

Theses and Dissertations

Lipolysis is crucial for cheese flavor development, as lipolytic enzymes convert fats into free fatty acids that enhance flavor. While Kid/Goat (KG) lipases are traditionally used in cheese production, microbial lipases like M. javanicus (MJ) and C. cylindracea (CC) provide vegetarian, cost-effective alternatives. This study compares the flavor, texture, and composition of Feta and Parmesan cheeses made with microbial lipases as a replacement for traditional lipase. Conventional cheese making techniques were used to make experimental batches of Feta and Parmesan cheeses using a standard KG lipase and two experimental lipases, CC and MJ, and comparing all three against a control …

Climate Change Impacts On Dryland Ecosystems, Tanner Tainui Aiono

Theses and Dissertations

Dryland ecosystems are some of the most prevalent ecosystems on Earth and have recently shown stress indicators from climate change. These water-limited systems are vulnerable to increases in temperature and changes in precipitation, especially when looking at carbon cycling dynamics across biological sol crusts and vegetation mortality patterns. This dissertation aims to 1) evaluate how precipitation dynamics, vegetation location, and microclimate conditions influence biological soil crust carbon conditions, and 2) evaluate how topographic influences drive patterns of plant mortality during prolonged drought on the Colorado Plateau. Using high-resolution monitoring of long-term NEE chambers, we found that intermediately disturbed biocrusts are …

Identification Of Salt Tolerance And Stress Response In Us Department Of Agriculture Tomato Germplasm At The Seedling Stage, Ibtisam Alatawi, Haizheng Xiong, Kenani Chiwina, Hanan Mohammedsaeed Alkabkabi, Qun Luo, Neelendra K. Joshi, Xiaolun Sun, Xuan Zhuang, Kai-Shu Ling, Ainong Shi

Horticulture Faculty Publications and Presentations

Abstract. Soil salinity is a significant abiotic factor that impedes sustainable crop pro- duction in key agricultural regions worldwide. Saline cultivation adversely affects soil quality, whereas the use of saline water for irrigation disrupts the physiological and biochemical processes of plants. Continuous irrigation with high salt concentrations leads to a gradual buildup of soil salinity, thus hindering optimal plant growth and development. Consequently, there is a growing emphasis on breeding salinity-tolerant cultivars of various crops. In this study, 71 tomato accessions sourced from 20 coun- tries and provided by the US Department of Agriculture were evaluated under con- trolled greenhouse …

Improving Food Security To Decrease Hypertension At An Urban Community Clinic, Christine S. Villalta

Master's Projects and Capstones

Diet and lifestyle changes have been proven to reduce blood pressure in patients with hypertension, and a key dietary approach aligned with this recommendation is the DASH diet, which includes consuming fruits and vegetables. Food insecurity, defined as lacking enough safe, nutritious food to maintain an active and healthy life, is a growing crisis in the United States, affecting 13.5% of U.S. households in 2023. This is especially significant for those whose chronic disease management depends on the accessibility of healthy food. An urban community clinic implemented a Food Security Program to decrease food insecurity and reduce hypertension among their …

Using Genomics And Transcriptomics As A Tool To Understand Unique Phenotypes Of Hemipteran Insects That Are Relevant To Agriculture And Public Health, Hunter Kelly Walt

Theses and Dissertations

In the past couple of decades, advances in genomic sequencing technology have caused an unprecedented increase in biological data. Because of the quantity and size of these datasets, the need for biologists with computational expertise also increased, and using these large genomic datasets has revolutionized the way we can answer biological questions. In this dissertation, I apply genomic and transcriptomic data to answer questions about insects of the order Hemiptera that are relevant to agriculture and public health. My dissertation mainly focuses on stink bugs (Hemiptera: Pentatomidae), many of which are agricultural pests, and bed bugs (Hemiptera: Cimicidae), which are …

Development Of Novel Nanocarriers With Multi Modal Action Against Lung Cancer, Gayathri K

Theses and Dissertations

Lung cancer ranks among the top causes of cancer-related deaths worldwide. The deteriorating environment and unhealthy lifestyle in the modern era has further contributed to the exponential increase in lung cancer incidence across the globe. Lung cancers fall under two major types based on the location of the tumour in the lung namely, small-cell lung cancer (SCLC) which is more aggressive, and non-small-cell lung cancer (NSCLC) which is more prevalent. Late diagnosis has been a major cause for poor prognosis as the cancer is detected only in an advanced stage.

Conventional therapies like chemotherapy, surgery and radiotherapy against lung cancer …

Oregon State Rank Assessment For Mardon Skipper (Polites Mardon), Eleanor P. Gaines

Institute for Natural Resources Publications

Oregon state conservation status assessment for Mardon skipper (Polites mardon) using NatureServe methodology, 2024.

A Kinetic Model For Compound Heterozygous Pathogenic Variants In Tyrosyl-Trna Synthetase Gene Yars2-Associated Neonatal Phenotype, Thomas W Christian, Sunita Maharjan, Sitao Yin, Yuka Yamaki, Isao Masuda, Fenglin Li, Colleen Muraresku, Sheila Clever, Rebecca Ganetzky, Ya-Ming Hou

Department of Biochemistry and Molecular Biology Faculty Papers

Human genetic disorders are often caused by mutations of compound heterozygosity, where each allele of the mutant gene harbors a different genetic lesion. However, studies of such mutations are hampered due to the lack of an appropriate model. Here we describe a kinetic model of compound heterozygous variants in an obligate enzyme dimer that contains one mutation in one monomer and the other mutation in the second monomer. This enzyme is encoded by human YARS2 for mitochondrial tyrosyl-tRNA synthetase (mt-TyrRS), which aminoacylates tyrosine to mt-tRNA^Tyr. YARS2 is a member of the genes for mt-aminoacyl-tRNA synthetases, where pathogenic mutations …

A Kid's Guide To Infectious Disease, Abby Carroll

Honors Theses

A Kid’s Guide to Infectious Disease is an educational illustrated book intended for young pediatric patients, ages three to five. This project was inspired by my personal interests, involvement at the University of Mississippi, and experience as a medical assistant. Over the past couple of years, I have had the opportunity to work as a medical assistant, interacting with many pediatric patients and their families at HealthPointe Primary Care. As a pre-physician assistant student studying biology, I was inspired to create a resource for these kids by both my classes at the University of Mississippi and my passion for pediatric …

Unmanned Aerial Systems (Uas) Image Preprocessing To Reduce Artifacts And Improve Geometric Registration When Generating Orthophoto Mosaics And 3d Models, Eddie Ironsmith

Electronic Theses and Dissertations

Drones can now be used to quickly collect imagery data in a highly automated way; however, individual images must be combined to form an orthomosaic or 3-Dimentional (3D) model using photogrammetry software. Currently, the existing software may generate erroneous output in the form of artifacts or positional errors caused by homogeneous areas, light reflections, object movement between photos, or sub-optimal algorithms. The goal of this research was to develop preprocessing algorithms that would filter movement (or other time or position-based differences) and areas of homogeneity. The hypothesis is that filtering these parts of the image would reduce artifacts and improve …

Innovative Methyl Bromide Alternatives: Efficacy Of Acetic Acid Coated Ham Nets And Carboxymethyl Cellulose Films In Inhibiting Mite Infestations On Dry-Cured Ham, Sawyer Wyatt Smith

Theses and Dissertations

Dry-cured hams may become infested with Tyrophagus putrescentiae (ham mites) during the aging process. Traditionally, methyl bromide (MB) fumigation has been used to control these infestations, but its phase-out due to environmental concerns has prompted the need for alternative methods. This study evaluated the effectiveness of acetic acid-coated ham nets and carboxymethyl cellulose (CMC)-based edible films with propylene glycol (PG) in mitigating mite infestations. Laboratory trials assessed the impact of these treatments on mite orientation, reproduction, infestation rates, and sensory quality. Results indicate that CMC films were effective at controlling mite growth and reproduction with minimal sensory impact. In contrast, …

Identification And Characterization Of The Antimicrobial Activities Of Pseudomonas Sp. Strain Wp18, Emma Suzanne Willis

Theses and Dissertations

Strain WP18 was isolated from disease suppressive soil of a soybean rhizosphere in the Mississippi Delta. Phylogenetic analysis supported that strain WP18 could represent a novel species within the genus Pseudomonas. This conclusion is supported by genome-wide bioinformatic analyses such as average nucleotide identity and genome to genome distance calculations. Further studies are needed to claim a novel bacterial species, which include cell fatty profiles, fingerprinting analysis, and polar lipid analysis based on the International Code for Nomenclature of Prokaryotes. Strain WP18 showed a broad-spectrum of antimicrobial activity against plant pathogenic bacteria and fungi that are economically important in agriculture, …

Identification Of Bacterial Species Composition And Diversity Of Chicken Breast Meat During Processing., Lizzie Raquel Zaldivar

Theses and Dissertations

Understanding the bacterial profile of chicken during processing is essential to identify spoilage-related bacteria. Using advanced methods like Oxford Nanopore sequencing, specific bacterial species on chicken meat can be identified. This study aimed to characterize bacterial composition and diversity on chicken breast during processing. Results showed a reduction in aerobic bacteria, E. coli, coliform, and lactic acid bacteria counts. However, three thermophilic bacteria, Anoxybacillus contaminants, Neobacillus thermocopriae, and Anoxybacillus flavithermus, dominated across processing steps. Notably, Pseudomonas species were undetected by conventional plating but identified via Nanopore sequencing, highlighting the need for molecular detection methods. Although antimicrobial interventions significantly reduced bacterial …

Development And Changes Over Time Of A Granola Bar Formulated With Sweet Potatoes, Meredith Kate Maynard

Theses and Dissertations

Sweet potatoes are a worldwide staple crop and granola bars are popular with consumers. This study aims to create a granola bar utilizing sweet potatoes and to assess its changes over time. Initial formulations tested minimum and maximum concentration of sweet potato (SP) puree, formulations, cooking type and time/temperature, humectants and preservatives. Bars containing 30 and 45% SP butter were chosen. Changes over time and descriptive sensory evaluation were conducted every 14d for 70d, with four treatments: a control bar and a bar with a preservative, each held at 25°C and 47°C. Water activity and moisture decreased by 0.05 and …

Effects Of A Snap-Ed Social Marketing Campaign On Behavior Change, Andrew Beall Cole

Theses and Dissertations

Introduction: This research studied the use of a social marketing campaign to address chronic diseases in the U.S., such as obesity, diabetes, hypertension and other cardiovascular diseases by assessing audience self-reported actions and evaluating message framing effects on participant intentions to change nutrition behavior and daily physical activity. Approach: Evaluate a social marketing campaign for effects on SNAP-Ed eligible clients and research message framing effects on audience’s intention to change health behaviors. Discussion: The HappyHealthy social marketing campaign launched in 2018 by Mississippi State University Extension. Outcome evaluation data (collected 2023) reported multiple correlations between core messages recalled and increased …

Evaluation Of Current Management Strategies For The Tarnished Plant Bug And Tobacco Thrips In Midsouthern Cotton, Hunter Lane Lipsey

Theses and Dissertations

The tarnished plant bug, Lygus lineolaris (Palisot de Beauvois), is an important economic pest of cotton, Gossypium hirsutum (L.), in the Midsouth region of the United States. An experiment was conducted to determine the impact of insecticide class loss on yield and Lygus populations in the recently commercialized ThryvOn cotton technology. Data indicated no significant yield loss when excluding any currently utilized insecticide class for tarnished plant bug management. An additional objective was to reevaluate the sampling interval necessary to scout ThryvOn cotton for Lygus. No significant differences were observed between a 3 or 7-day sample interval compared to plots …

Effects Of Eugenol And Carvacrol In Combination Against Salmonella In Hummus, Lauryn Ashley Heidelberg

Theses and Dissertations

Hummus consumption has risen but multiple foodborne outbreaks due to Salmonella contamination have been reported. Essential oils (EOs) eugenol and carvacrol have been found to inhibit the growth and survival of Salmonella in food products. The objective was to evaluate antibacterial properties of various concentrations of eugenol (EU) and carvacrol (CA), alone or in combination (EUCA) against Salmonella in vitro and in hummus. Eugenol demonstrated a MIC of 0.125 mg/mL and an MBC of 0.25 mg/mL, while carvacrol showed a MIC of 0.0625 mg/mL and an MBC of 0.125 mg/mL. In the hummus study, 2% EUCA was the most effective …