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Full-Text Articles in Life Sciences

Hubungan Gangguan Mental Emosional Dan Obesitas Sentral: Literature Review, Dwi Rahmawati, Ratna Djuwita Dec 2024

Hubungan Gangguan Mental Emosional Dan Obesitas Sentral: Literature Review, Dwi Rahmawati, Ratna Djuwita

Jurnal Epidemiologi Kesehatan Indonesia

The prevalence of central obesity, both globally and in Indonesia, continues to increase. Mental and emotional disorders are one of the contributing factors to central obesity. In previous studies, it was known that the relationship between emotional mental disorders and obesity can occur in bidirections, where emotional mental disorders can cause central obesity or vice versa. This literature review aims to find out more about the relationship between emotional mental disorders and central obesity from various countries. The searching for articles used 4 databases (Scopus, Science Direct, Proquest, and Pubmed) with the Preferred Reporting Items for Systematic Review and Meta-Analysis …


Foreword From Handling Editor - 13th Edition, Ahyahudin Sodri Dec 2024

Foreword From Handling Editor - 13th Edition, Ahyahudin Sodri

Journal of Environmental Science and Sustainable Development

We are delighted to present the 13th edition of JESSD, published in December 2024. We have selected ten of the best articles for this edition that related with topic of Environmental Science and Sustainable Development.


Spatial Segregation And Socioeconomic Disparities In Urban Land Use Patterns, Intan Lestari, Hayati Sari Hasibuan, Vevin Syoviawati Ardiwijaya Dec 2024

Spatial Segregation And Socioeconomic Disparities In Urban Land Use Patterns, Intan Lestari, Hayati Sari Hasibuan, Vevin Syoviawati Ardiwijaya

Journal of Environmental Science and Sustainable Development

Jakarta, a city that has continued to develop, is marked by the growth of population in Jakarta. This growth has been accompanied by an increasing demand for land, resulting in spatial segregation. Some areas have large expanses of land, while others are densely populated and cramped. The purpose of this study is to analyze spatial segregation in the Penjaringan and Pluit Subdistricts of North Jakarta. The research employs a qualitative descriptive analysis method, spatial analysis using Moran's and Getis-Ord Gi*, and a literature review enriched with interviews. The research findings indicate clear spatial segregation between Pluit and Penjaringan, divided into …


Impact Of Urban Development On Uv Exposure: A Clustering And Machine Learning Assessment, Taufik Roni Sahroni Mr., Verdi Yasin, Lulut Alfaris, Reza Ariefka, Ruben Cornelius Siagian, Mohammad Alfin Karim, Nana Rahdiana, Ade Suhara Dec 2024

Impact Of Urban Development On Uv Exposure: A Clustering And Machine Learning Assessment, Taufik Roni Sahroni Mr., Verdi Yasin, Lulut Alfaris, Reza Ariefka, Ruben Cornelius Siagian, Mohammad Alfin Karim, Nana Rahdiana, Ade Suhara

Journal of Environmental Science and Sustainable Development

The relocation of Indonesia's capital city is anticipated to promote inclusive economic growth while embracing cultural diversity. However, this transition may affect ultraviolet (UV) radiation exposure patterns. The study investigated variations in UV exposure in the IKN region, focusing on urban development factors such as land use and population density that affect public health, sun protection, and skin cancer prevention. The research hypothesized that UV radiation is significantly correlated with these factors. UV Index data from 2010-2023, a hierarchical clustering method, identifies complex data patterns without determining the number of clusters. XGBoost, a machine learning model, was used for handling …


Road Safety Assessment For Accident And Non-Accident Cases Supporting Sustainable Development Goals 2030, Brian Nararya Nugraha, Sekar Warangi Nurcahyati, Hizkia Adhikaratma, Martha Leni Siregar Dec 2024

Road Safety Assessment For Accident And Non-Accident Cases Supporting Sustainable Development Goals 2030, Brian Nararya Nugraha, Sekar Warangi Nurcahyati, Hizkia Adhikaratma, Martha Leni Siregar

Journal of Environmental Science and Sustainable Development

Halving the number of global deaths and injuries from road traffic accidents is one target of the Sustainable Development Goals 2030, which is still a challenging problem in Indonesia. However, the majority of research on this topic uses accident-based methods, which limits the safety analysis. Two road safety assessment methods are used to close the gap, with the addition of non-accident-based methods such as Road Safety Audits (RSA). The Margonda Raya Road, which is categorised as a traffic accident blackspot, was selected for the case study. For this, a field survey of the road segment is carried out. To minimise …


Evaluation Of Microbial Contamination In Tube Well And Filter Water Of Lahore And Treatment With Copper Nanoparticles, Khadeeja Moazzam, Sumaira Mazhar Dec 2024

Evaluation Of Microbial Contamination In Tube Well And Filter Water Of Lahore And Treatment With Copper Nanoparticles, Khadeeja Moazzam, Sumaira Mazhar

Journal of Bioresource Management

Water contamination is a global issue and different techniques are being devised to reduce water contamination. Among these techniques, use of nanoparticles for water purification is an efficient and cost-effective method with minimum or no side effect. Metal nanoparticles are known for their antibacterial activity against various pathogens. Synthesis of these nanoparticles using green synthesis methods minimizes the harmful effects while ensuring their antibacterial activity. Therefore, in the present work, it was aimed to evaluate the microbial contamination in water samples collected from different tube wells and filter plants located in different areas of Lahore, Pakistan for the isolation of …


Raw Milk Collection Diversity And Determinants Of Physicochemical And Microbiological Quality In Algerian Small Farms, Nasria Benamara, Houari Yerou, Hamza Belkhodja, Toufik Madani Dec 2024

Raw Milk Collection Diversity And Determinants Of Physicochemical And Microbiological Quality In Algerian Small Farms, Nasria Benamara, Houari Yerou, Hamza Belkhodja, Toufik Madani

Journal of Bioresource Management

Milk sector in Algeria presents lasting supply instability and its development policy has not achieved the expected results. The interest in developing local dairy production therefore has been a priority for public authorities. Our work aims to analyze raw milk collection diversity at the GIPLAIT dairy in Tizi (Mascara) and assess their physicochemical and microbiological quality. The typology of raw milk collection was determined from upstream, the farm to the dairy processing factory. The quality of the milk was determined by carrying out both physicochemical analyses (pH, Dornic acidity, butter content, protein content, density and total dry extract) and microbiological …


Dental Remains Of Pachyportax (Bovidae) From Late Miocene Deposits Of Jhelum, Punjab, Pakistan, Saira Ashfaq, Muhammad Rizwan, Maryam Mushtaq, Umar Naveed Saqib, Sheraz Khan, Hifza Zahid, Muhammad Arshaid, Tabassum Nawaz Dec 2024

Dental Remains Of Pachyportax (Bovidae) From Late Miocene Deposits Of Jhelum, Punjab, Pakistan, Saira Ashfaq, Muhammad Rizwan, Maryam Mushtaq, Umar Naveed Saqib, Sheraz Khan, Hifza Zahid, Muhammad Arshaid, Tabassum Nawaz

Journal of Bioresource Management

The upper Dhok Pathan Formation is characterized to newly found Pachyportax fossils from Late Miocene outcrops in the Hasnot region. The discovered dental remains of Pachyportax include upper and lower molars. Based on morphometry, the examined tooth material was identified, and the specimens were categorized as Pachyportax latidens and Pachyportax nagri. A well-known example is Pachyportax latidens, but Pachyportax nagrii stands out due to its rare fossil record from the middle Siwaliks. Potwar Pleateu is the most productive region for the deposition of vertebrate fossils (Pilbeam et al., 1979; Badgley et al., 2008). Bovids in open environments are …


Bioresource Management Via Least Cost Feed Formulation For Red Tilapia (Oreochromis Sp.): Application Of Linear Programming Technique, Boudjema Kamel, Redhouane Benfares, Affaf Kord, Toufik Milla, Belkacem Guenachi, Lynda Frai, Rachida Itcher, Hocine Kherzane Dec 2024

Bioresource Management Via Least Cost Feed Formulation For Red Tilapia (Oreochromis Sp.): Application Of Linear Programming Technique, Boudjema Kamel, Redhouane Benfares, Affaf Kord, Toufik Milla, Belkacem Guenachi, Lynda Frai, Rachida Itcher, Hocine Kherzane

Journal of Bioresource Management

The method of linear programming (LP) was utilized to determine the relationship between the composition of nutrients of each ingredients, specifications for raw materials, cost and requirements for nutrients of the red tilapia (Oreochromis sp.), in order to define: (1) least cost ration formulation, (2) least cost diet, (3) minimum price of producing a particular diet after meeting a number of requirements. The resulting LP models were solved using the simplex algorithm. Therefore, our results show that, formulated feed had high protein content (31.92 %), Lipid (2.53), Moisture (9.10 %) and Ash (9.00 %). The utilization of diet …


Economic Analysis And Profitability Of Honey Production And Marketing In Cross River State, Nigeria, Joseph A. Ugbe, Tee T.N., Ancha P.U Dec 2024

Economic Analysis And Profitability Of Honey Production And Marketing In Cross River State, Nigeria, Joseph A. Ugbe, Tee T.N., Ancha P.U

Journal of Bioresource Management

The significance of honey in the socio-economic livelihoods of rural and semi-urban populations is paramount, as it tackles issues such as unemployment, income, and ecosystem preservation. The decrease in the timber industry has caused numerous individuals who rely on forests for their income to be without jobs, making it difficult to find other ways to make a living. This study examines the economic analysis and profitability of honey production and marketing in Cross River State, Nigeria, over 5 years (2017-2021) for sustainable forest management. Six hundred and eighty-four (684) respondents were selected from three ecological zones in the state using …


The Nutritional And Biotechnological Potential Of Amaranth: A Versatile Plant For Health And Sustainability, Zeliha Selamoglu, Muhammad Yasir Naeem, Yaira Rakhmetova, Tulkinzhon Gaipov Dec 2024

The Nutritional And Biotechnological Potential Of Amaranth: A Versatile Plant For Health And Sustainability, Zeliha Selamoglu, Muhammad Yasir Naeem, Yaira Rakhmetova, Tulkinzhon Gaipov

Journal of Bioresource Management

The amaranth plant, originating from Central and South America, was a staple food for ancient civilizations like the Aztecs and Inca. Today, it is cultivated across tropical and subtropical regions, including Africa, Asia, and North America. Belonging to the Amaranthaceae family and comprising approximately 60 species, amaranth is valued for its adaptability to various soil and climatic conditions. This versatile crop is a nutrient-dense food source with a diverse chemical composition and numerous bioactive compounds, particularly in its seeds. Naturally gluten-free, amaranth is ideal for individuals with celiac disease or gluten sensitivity. It provides a complete profile of essential amino …


A Review On Wolbachia- A Viable Alternative To Control Aedes-Born Arboviral Diseases, Fatima Khizar, Iqra Mushtaq, Hafsa Masud, Muhammad Sajjad Sarwar Dec 2024

A Review On Wolbachia- A Viable Alternative To Control Aedes-Born Arboviral Diseases, Fatima Khizar, Iqra Mushtaq, Hafsa Masud, Muhammad Sajjad Sarwar

Journal of Bioresource Management

The endemic geographic ranges of mosquitoes are expanding due to various anthropogenic activities including rapid international travel and trade, urbanization, deforestation, and global warming. Hence, Aedes-borne arboviral diseases like dengue, chikungunya, yellow fever, or Zika infections would cause severe future outbreaks in non-endemic regions of the world. This threat to global public health highlights an urgent need for the development of efficient and effective mosquito control strategies. To date, a large number of mosquito vector-control strategies have been developed. Each of them has its strengths and weaknesses but the use of intracellular, endosymbiotic reproductive parasitic bacteria named Wolbachia pipientis …


Ethephon Application And Nitrogen Optimization Through Foliar Urea For Okra Production, Muhammad Usaid, Muhammad Yaisr Ali, Ihsan Ul Haq, Sajid Ali, Huzaifa Ihsan, Arslan Rafique, Kalim Ullah, Khalid Nisar, Khan Badshah, Mian Muhammad Huzaifa, Muhammad Shoaib Muteezai Dec 2024

Ethephon Application And Nitrogen Optimization Through Foliar Urea For Okra Production, Muhammad Usaid, Muhammad Yaisr Ali, Ihsan Ul Haq, Sajid Ali, Huzaifa Ihsan, Arslan Rafique, Kalim Ullah, Khalid Nisar, Khan Badshah, Mian Muhammad Huzaifa, Muhammad Shoaib Muteezai

Journal of Bioresource Management

To mitigate the environmental impact of excessive urea use, this study investigates the foliar application of urea and ethephon as a more efficient alternative to soil application, aiming to optimize nitrogen use while sustaining the growth and yield of okra. The research was conducted using a randomized complete block design with two factors, replicated four times. Factor A included ethephon levels with a control (E0 = Control, E1 = 150 ppm, E2 = 250 ppm, E3 = 350 ppm), while Factor B comprised two urea levels and a control (U0 = Control, U1 = 1%, U2 = 2 %). The …


An Analysis Of Moth Diversity In Garbhanga Reserve Forest, Basistha, Assam, India, Golphina Ahmed, Arup Nama Das, Lupamudra Borah, Rezina Ahmed Dec 2024

An Analysis Of Moth Diversity In Garbhanga Reserve Forest, Basistha, Assam, India, Golphina Ahmed, Arup Nama Das, Lupamudra Borah, Rezina Ahmed

Journal of Bioresource Management

The Garbhanga Reserve Forest, located on the south-western side of Guwahati City, covers an area of about 117 km2 and borders the foothills of Meghalaya (26°05´36˝N and 91°44´57˝E). Despite the constant threat of exploitation due to its proximity to the rapidly developing city, this area hosts a diverse ecosystem of moths and butterflies. In a study conducted over one year from January 2022 to December 2022, a total of 140 moth species were documented, with the majority belonging to the Erebidae family (46 species) and 1090 individuals, followed by the Crambidae family (31 species) and 704 individuals. The dominance of …


Determination Of Manganese Concentration In Forages, Soil, Sewage Water Of Three Suburban Areas Of Sargodha, Pakistan, Iqra Anwar, Zafar Iqbal Khan, Kafeel Ahmad, Naila Riaz, Faiza Zubair, Asma Ashfaq, Muhammad Fahad Ullah, Farzana Siddique, Ijaz Rasool Noorka, Abid Ejaz, Maloofa Manzoor, Umbreen Bibi, Hafiza Memona Nazir, Saif Ullah Dec 2024

Determination Of Manganese Concentration In Forages, Soil, Sewage Water Of Three Suburban Areas Of Sargodha, Pakistan, Iqra Anwar, Zafar Iqbal Khan, Kafeel Ahmad, Naila Riaz, Faiza Zubair, Asma Ashfaq, Muhammad Fahad Ullah, Farzana Siddique, Ijaz Rasool Noorka, Abid Ejaz, Maloofa Manzoor, Umbreen Bibi, Hafiza Memona Nazir, Saif Ullah

Journal of Bioresource Management

For irrigation of soil utilization of wastewater has risen significantly in the past few years. This wastewater often have large amount of trace elements and heavy metals, many of which are non-essential and harmful to living organisms such as plants, animals, and humans. In Pakistan, particularly around suburban areas, it is common to use this polluted water for growing vegetables. When such water is used for irrigation over an extended period of time, toxic substances can accumulate in the soil, potentially causing toxicity to plants and degrading soil quality. The samples analyzed in the study were prepared using the wet …


Green Synthesis Of Titanium Oxide Nanoparticles From Leaves Extract Of Cassia Fistula And Evaluation Of Their Antimicrobial Activities, Anum Sadiq, Muhammad Shahbaz, Ayesha Shahbaz, Badra Younis, Shmsa Manzoor, Syeda Sabahat Fiaz Dec 2024

Green Synthesis Of Titanium Oxide Nanoparticles From Leaves Extract Of Cassia Fistula And Evaluation Of Their Antimicrobial Activities, Anum Sadiq, Muhammad Shahbaz, Ayesha Shahbaz, Badra Younis, Shmsa Manzoor, Syeda Sabahat Fiaz

Journal of Bioresource Management

The fields of biotechnology, pharmacy, agriculture, and health could all benefit greatly from advances in Nano science and nanotechnology. The synthesis, characterizations, and antibacterial qualities of titanium dioxide (TiO2) nanoparticles made using Cassia fistula leaves in a green synthesis procedure are the main objectives of this work which was carried out between September 2021 and June 2022. Four methods were used to analyse the structure of titanium dioxide nanoparticles: FTIR, XRD, and SEM. According to FTIR research, TiO2 exhibited stretching vibrations at 1500–1600 cm-1 and a UV absorption peak between 250 and 400 nm. Nanoparticle diameters ranged from 145.6 to …


Multi-Sensor Data Fusion And Gis-Drastic Integration For Groundwater Vulnerability Assessment With Rainfall Consideration, Wu Jiazhe, Dai Xinrui, Su Yangcheng, Zheng Xiangtian, Bushra Ghaffar, Rabiya Nasir, Ahsan Jamil, Zeeshan Zafar, Mohammad Suhail Meer, M. Abdullah-Al-Wadud, Rahila Naseer, Hesham El-Askary Dec 2024

Multi-Sensor Data Fusion And Gis-Drastic Integration For Groundwater Vulnerability Assessment With Rainfall Consideration, Wu Jiazhe, Dai Xinrui, Su Yangcheng, Zheng Xiangtian, Bushra Ghaffar, Rabiya Nasir, Ahsan Jamil, Zeeshan Zafar, Mohammad Suhail Meer, M. Abdullah-Al-Wadud, Rahila Naseer, Hesham El-Askary

Mathematics, Physics, and Computer Science Faculty Articles and Research

In many areas of the world, particularly in arid and semi-arid regions, groundwater is the primary source of fresh water, and it supplies around one-third of the world's fresh water. Agriculture is the primary economic sector on the coast in the southern district (Nowshera). More food productivity is required due to the expanding population and diminishing agricultural lands, which increases the use of chemical pesticides and fertilizers in farming. The current study was conducted in northwestern parts of Pakistan to evaluate the impacts of the frequent use of pesticides and fertilizers in agricultural fields. Nine hydrogeological parameters were considered, and …


Cropsync: Ai-Powered Sustainable Crop Management, Ziad Doughan, Ibrahim Mneimneh, Zouheir Nakouzi, Noor Al Khaib, Samer Damaj, Jamal Chaaban, Hamza Mrad, Sari Itani Dec 2024

Cropsync: Ai-Powered Sustainable Crop Management, Ziad Doughan, Ibrahim Mneimneh, Zouheir Nakouzi, Noor Al Khaib, Samer Damaj, Jamal Chaaban, Hamza Mrad, Sari Itani

BAU Journal - Science and Technology

CropSync is a smart agriculture system that uses AI and IoT technologies to enable sustain- able crop management and precision farming. The system aims to address the challenges faced by the agriculture sector, such as increasing food production to meet global population demands while minimizing environmental impact. CropSync integrates sensors, cameras, and cloud-based analytics to provide farmers with real-time insights and recommendations for optimizing crop cul- tivation. The system upholds engineering professional and ethical standards, considering broader social, environmental, and economic implications. From a social perspective, CropSync improves food security and enhances farmers’ livelihoods through increased productivity and efficient re- …


Development Of An Injectable Chitosan-Based Bioink For Enhanced Bone Fracture Healing Via Msc-Derived Osteogenesis, Zeina H. Adel, Jana A. Hassan, Hala H. Muhammed, Haneen M. Elsaeid, Raghad M. Nasr, Ahmed M. Deghidy Dec 2024

Development Of An Injectable Chitosan-Based Bioink For Enhanced Bone Fracture Healing Via Msc-Derived Osteogenesis, Zeina H. Adel, Jana A. Hassan, Hala H. Muhammed, Haneen M. Elsaeid, Raghad M. Nasr, Ahmed M. Deghidy

BAU Journal - Science and Technology

Worldwide, bone fractures are a major public health concern and, there is an urgent requirement to create new treatments to accelerate the rate of the bone healing process. This research mainly relies on creating a hydrogel that satisfies the bone marrow mesenchymal stem cells (BM-MSCs) and makes it a suitable medium to differentiate into osteogenic cells. We combine the BM-MSCs with a chitosan polymer-based hydrogel, infused with PVA to enhance bone healing, this unique mixture forms " Bioink ". We induced a closed fracture model in the rat's right humerus, followed by injection of a single dosage of bioink. On …


What Is It Like To Be A Diplomat? Reflections On Donald Griffin And Emotion, Oliver H. Turnbull Dec 2024

What Is It Like To Be A Diplomat? Reflections On Donald Griffin And Emotion, Oliver H. Turnbull

Animal Sentience

This commentary addresses three aspects of Donald Griffin’s work: (1) his thoughts beyond cognition, on emotion; (2) his views on the earliest origins of mind, including primitive forms of consciousness; and (3) his diplomatic use of memorable phrases to facilitate change.


Food For Thought: A Qualitative Assessment Of Medical Trainee And Faculty Perceptions Of Nutrition Education, Olivia Kunitsky, Mahdi Taye, Karla Feeley, Hugh Johnson, Abigail Glynn, Avery Stivale, Matthew Hamers, Alexis Notarianni, Sireesha Mamillapalli, Gabi Waite, Sonia Lobo Dec 2024

Food For Thought: A Qualitative Assessment Of Medical Trainee And Faculty Perceptions Of Nutrition Education, Olivia Kunitsky, Mahdi Taye, Karla Feeley, Hugh Johnson, Abigail Glynn, Avery Stivale, Matthew Hamers, Alexis Notarianni, Sireesha Mamillapalli, Gabi Waite, Sonia Lobo

Department of Neurology Faculty Papers

BACKGROUND: The American Society of Clinical Nutrition recommends 37 to 44 h of undergraduate medical nutrition education. The Total Health Curriculum at Geisinger Commonwealth School of Medicine (GCSOM) contains 14 h of objective-based nutritional instruction. This study aimed to examine the perceptions of key stakeholders regarding the role of nutrition in medicine and to identify barriers, opportunities for improvement, and roles/responsibilities for innovative implementation of nutrition education.

METHODS: This exploratory, qualitative study employed a phenomenological approach and inductive coding process. Purposive sampling recruited medical students, undergraduate medical education (UME) faculty, physicians, and other healthcare professionals at GCSOM and affiliated clinical …


Nos Inhibition Sensitizes Metaplastic Breast Cancer To Pi3k Inhibition And Taxane Therapy Via C-Jun Repression, Tejaswini Reddy, Akshjot Puri, Liliana Guzman-Rojas, Christoforos Thomas, Wei Qian, Jianying Zhou, Hong Zhao, Bijan Mahboubi, Adrian Oo, Young-Jae Cho, Baek Kim, Jose Thaiparambil, Roberto Rosato, Karina Ortega Martinez, Maria Florencia Chervo, Camila Ayerbe, Noah Giese, David Wink, Stephen Lockett, Stephen Wong, Jeffrey Chang, Savitri Krishnamurthy, Clinton Yam, Stacy Moulder, Helen Piwnica-Worms, Funda Meric-Bernstam, Jenny Chang Dec 2024

Nos Inhibition Sensitizes Metaplastic Breast Cancer To Pi3k Inhibition And Taxane Therapy Via C-Jun Repression, Tejaswini Reddy, Akshjot Puri, Liliana Guzman-Rojas, Christoforos Thomas, Wei Qian, Jianying Zhou, Hong Zhao, Bijan Mahboubi, Adrian Oo, Young-Jae Cho, Baek Kim, Jose Thaiparambil, Roberto Rosato, Karina Ortega Martinez, Maria Florencia Chervo, Camila Ayerbe, Noah Giese, David Wink, Stephen Lockett, Stephen Wong, Jeffrey Chang, Savitri Krishnamurthy, Clinton Yam, Stacy Moulder, Helen Piwnica-Worms, Funda Meric-Bernstam, Jenny Chang

Faculty, Staff and Student Publications

Metaplastic breast cancer (MpBC) is a highly chemoresistant subtype of breast cancer with no standardized therapy options. A clinical study in anthracycline-refractory MpBC patients suggested that nitric oxide synthase (NOS) inhibitor NG-monomethyl-l-arginine (L-NMMA) may augment anti-tumor efficacy of taxane. We report that NOS blockade potentiated response of human MpBC cell lines and tumors to phosphoinositide 3-kinase (PI3K) inhibitor alpelisib and taxane. Mechanistically, NOS blockade leads to a decrease in the S-nitrosylation of c-Jun NH


Promotion Of Overall Health During The Adolescent Period For Adolescent Girls Through Teaching Program – A Quasi-Experimental Study, Anusuya V. Prabhu Mrs., Sangeetha Priyadarshini, Mamatha Shivananda Pai Dr., Yashoda Sathish Dr. Dec 2024

Promotion Of Overall Health During The Adolescent Period For Adolescent Girls Through Teaching Program – A Quasi-Experimental Study, Anusuya V. Prabhu Mrs., Sangeetha Priyadarshini, Mamatha Shivananda Pai Dr., Yashoda Sathish Dr.

Manipal Journal of Nursing and Health Sciences

Background

Adolescence, characterized by physical, psychological, and behavioral transformations, often elicits varied responses from girls. Adequate data can aid them in navigating these changes effectively. The study aimed to assess adolescent girls' understanding of puberty, psychological transitions, reproductive health, and the importance of a balanced diet during this developmental stage.

Method:

In this quasi-experimental investigation, purposive sampling was utilized to gather data. The study comprised 184 teenage girls aged between 10 and 19, with 92 participants assigned to both the intervention and control groups. Data were collected using a pre-designed questionnaire consisting of thirty-one questions aimed at assessing knowledge of …


The Win Ratio Approach In Bayesian Monitoring For Two-Arm Phase Ii Clinical Trial Designs With Multiple Time-To-Event Endpoints, Xinran Huang, Jian Wang, Jing Ning Dec 2024

The Win Ratio Approach In Bayesian Monitoring For Two-Arm Phase Ii Clinical Trial Designs With Multiple Time-To-Event Endpoints, Xinran Huang, Jian Wang, Jing Ning

Faculty, Staff and Student Publications

To assess the preliminary therapeutic impact of a novel treatment, futility monitoring is commonly employed in Phase II clinical trials to facilitate informed decisions regarding the early termination of trials. Given the rapid evolution in cancer treatment development, particularly with new agents like immunotherapeutic agents, the focus has often shifted from objective response to time-to-event endpoints. In trials involving multiple time-to-event endpoints, existing monitoring designs typically select one as the primary endpoint or employ a composite endpoint as the time to the first occurrence of any event. However, relying on a single efficacy endpoint may not adequately evaluate an experimental …


Bayesian Nonparametric Model For Heterogeneous Treatment Effects With Zero-Inflated Data, Chanmin Kim, Yisheng Li, Ting Xu, Zhongxing Liao Dec 2024

Bayesian Nonparametric Model For Heterogeneous Treatment Effects With Zero-Inflated Data, Chanmin Kim, Yisheng Li, Ting Xu, Zhongxing Liao

Faculty, Staff and Student Publications

One goal of precision medicine is to develop effective treatments for patients by tailoring to their individual demographic, clinical, and/or genetic characteristics. To achieve this goal, statistical models must be developed that can identify and evaluate potentially heterogeneous treatment effects in a robust manner. The oft-cited existing methods for assessing treatment effect heterogeneity are based upon parametric models with interactions or conditioning on covariate values, the performance of which is sensitive to the omission of important covariates and/or the choice of their values. We propose a new Bayesian nonparametric (BNP) method for estimating heterogeneous causal effects in studies with zero-inflated …


Biphasic Models Improved S-Metolachlor Dissipation Endpoint Predictions, K. Badou-Jeremie Kouame, Mary Savin, Cammy Willett, Thomas R. Butts, Erin Grantz, Matthew Bertucci, Samantha E. Robinson, Rodrigo Werle, Nilda Roma-Burgos Dec 2024

Biphasic Models Improved S-Metolachlor Dissipation Endpoint Predictions, K. Badou-Jeremie Kouame, Mary Savin, Cammy Willett, Thomas R. Butts, Erin Grantz, Matthew Bertucci, Samantha E. Robinson, Rodrigo Werle, Nilda Roma-Burgos

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Accurate predictions of herbicide dissipation endpoints are essential for making environmental management decisions, estimating the duration of weed control, and deciding crop replant and rotation options. The performance of the single first-order (SFO), first-order multiple-compartment (FOMC), bi-exponential (BEXP), first-order double-exponential decay (FODED), and first-order two-compartment (FOTC) was evaluated to describe S-metolachlor dissipation. Results showed that the BEXP and FOTC were not appropriate. The FODED was ranked as the top model with the lowest Akaike's information criterion (AICc) value among the other three candidate models and was followed by the FOMC model. The SFO displayed the largest root mean square …


What Is It Like To Be A Cognitive Ethologist?, Anne Wordsworth She/Her Dec 2024

What Is It Like To Be A Cognitive Ethologist?, Anne Wordsworth She/Her

Animal Sentience

Donald Griffin not only made the study of animal minds acceptable for scientific investigation but the work of the cognitive ethologists that he inspired made animals and their lives fascinating and accessible to the greater public. The scrupulously detailed examination of his life and work by Ristau ensures that this history will always be there to respect his work and his legacy


Chiropterophagy By The Siberian Weasel (Mustela Sibirica): The First Record In The Russian Far East, Valeriya E. Omelko, Mikhail P. Tiunov Dec 2024

Chiropterophagy By The Siberian Weasel (Mustela Sibirica): The First Record In The Russian Far East, Valeriya E. Omelko, Mikhail P. Tiunov

International Journal of Speleology

Chiropterophagy is a widespread phenomenon, but only one case of bat consumption by sable has been documented in the Russian Far East. This study presents the first recorded instance of chiropterophagy by the Siberian weasel (Mustela sibirica) in the southern Russian Far East, based on excrement collected from the Solyanik Cave in the southern Sikhote-Alin Mountains in 2007. The excrement included bones from three bat species (Murina hilgendorfi, Myotis bombinus, Plecotus ognevi) and one vole species (Myodes rutilus). Our findings suggest that the Siberian weasel visits caves during the cold season, although …


Parp Inhibition Radiosensitizes Brca1 Wildtype And Mutated Breast Cancer To Proton Therapy, Mariam Ben Kacem, Scott J Bright, Emma Moran, David B Flint, David K J Martinus, Broderick X Turner, Ilsa Qureshi, Rishab Kolachina, Mandira Manandhar, Poliana C Marinello, Simona F Shaitelman, Gabriel O Sawakuchi Dec 2024

Parp Inhibition Radiosensitizes Brca1 Wildtype And Mutated Breast Cancer To Proton Therapy, Mariam Ben Kacem, Scott J Bright, Emma Moran, David B Flint, David K J Martinus, Broderick X Turner, Ilsa Qureshi, Rishab Kolachina, Mandira Manandhar, Poliana C Marinello, Simona F Shaitelman, Gabriel O Sawakuchi

Faculty, Staff and Student Publications

Aggressive breast cancers often fail or acquire resistance to radiotherapy. To develop new strategies to improve the outcome of aggressive breast cancer patients, we studied how PARP inhibition radiosensitizes breast cancer models to proton therapy, which is a radiotherapy modality that generates more DNA damage in the tumor than standard radiotherapy using photons. Two human BRCA1-mutated breast cancer cell lines and their isogenic BRCA1-recovered pairs were treated with a PARP inhibitor and irradiated with photons or protons. Protons (9.9 and 3.85 keV/µm) induced higher cell kill independent of BRCA1 status. PARP inhibition amplified the cell kill effect to both photons …


Cancer Organoids As Reliable Disease Models To Drive Clinical Development Of Novel Therapies, Giovanni Blandino, Ronit Satchi-Fainaro, Ingeborg Tinhofer, Giovanni Tonon, Sarah C Heilshorn, Yong-Jun Kwon, Ana Pestana, Carlotta Frascolla, Luca Pompili, Aurora Puce, Sara Iachettini, Annalisa Tocci, Sofia Karkampouna, Marianna Kruithof-De Julio, Piera Tocci, Nicla Porciello, Klizia Maccaroni, Daniela Rutigliano, Xiling Shen, Gennaro Ciliberto Dec 2024

Cancer Organoids As Reliable Disease Models To Drive Clinical Development Of Novel Therapies, Giovanni Blandino, Ronit Satchi-Fainaro, Ingeborg Tinhofer, Giovanni Tonon, Sarah C Heilshorn, Yong-Jun Kwon, Ana Pestana, Carlotta Frascolla, Luca Pompili, Aurora Puce, Sara Iachettini, Annalisa Tocci, Sofia Karkampouna, Marianna Kruithof-De Julio, Piera Tocci, Nicla Porciello, Klizia Maccaroni, Daniela Rutigliano, Xiling Shen, Gennaro Ciliberto

Faculty, Staff and Student Publications

On September 23-24 (2024) the 6th Workshop IRE on Translational Oncology, titled "Cancer Organoids as Reliable Disease Models to Drive Clinical Development of Novel Therapies," took place at the IRCCS Regina Elena Cancer Institute in Rome. This prominent international conference focused on tumor organoids, bringing together leading experts from around the world.A central challenge in precision oncology is modeling the dynamic tumor ecosystem, which encompasses numerous elements that evolve spatially and temporally. Patient-derived 3D culture models, including organoids, explants, and engineered or bioprinted systems, have recently emerged as sophisticated tools capable of capturing the complexity and diversity of cancer cells …