Open Access. Powered by Scholars. Published by Universities.®

Life Sciences Commons™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 19291 - 19320 of 255927

Full-Text Articles in Life Sciences

Students’ Concept Maps Profile On Environmental Pollution Material During The Covid-19 Pandemic, Sunarni Sunarni, Sri Widoretno, Puguh Karyanto, Bowo Sugiharto, Sri Dwiastuti, Chandra Adi Prabowo Dec 2024

Students’ Concept Maps Profile On Environmental Pollution Material During The Covid-19 Pandemic, Sunarni Sunarni, Sri Widoretno, Puguh Karyanto, Bowo Sugiharto, Sri Dwiastuti, Chandra Adi Prabowo

Jurnal Pendidikan Sains

The study investigates the performance of students in constructing Concept Maps (CM) related to environmental pollution material during the COVID-19 pandemic. The data reveals that the overall achievement in CM construction was suboptimal, with no component reaching more than half of its maximum potential. The highest achievement was recorded in the valid relationship component, which attained 9.75% of its maximum possible score. This was followed by the hierarchy component, achieving 7.34%, and the branching component at 3.42%. The pattern component ranked fourth with 1.31%, closely followed by the example component at 1.30%. The lowest performance was observed in the crosslink …


Analysis Of Students’ Problem-Solving Skills In Newton’S Law With 5e Learning Cycle, Nidya Desyana, Sutopo Sutopo, Nandang Mufti Dec 2024

Analysis Of Students’ Problem-Solving Skills In Newton’S Law With 5e Learning Cycle, Nidya Desyana, Sutopo Sutopo, Nandang Mufti

Jurnal Pendidikan Sains

The aim of this study is to identify students’ problem-solving skills in Newton’s laws through the implementation of the 5E learning cycle in the classroom. A pre-experimental design with a one-group pretest-posttest approach was employed. Data on problem-solving skills were collected from students’ pre-test and post-test responses to two essay questions. The indicator with the highest percentage of problem-solving skills was useful description (83% of students), while the indicator with the lowest percentage was specific application of physics (33% of students). Due to the non-normal distribution of the data, the Wilcoxon test was utilized. The results indicated a significant difference …


Development Of Conceptual Scaffolding-Assisted Formative Assessment For Enhancing Understanding Of Temperature And Heat, Ana Lailatul Fitriyah, Sentot Kusairi, Markus Diantoro Dec 2024

Development Of Conceptual Scaffolding-Assisted Formative Assessment For Enhancing Understanding Of Temperature And Heat, Ana Lailatul Fitriyah, Sentot Kusairi, Markus Diantoro

Jurnal Pendidikan Sains

This research aims to develop formative assessment media assisted by conceptual scaffolding to improve students’ understanding of temperature and heat, test its validity and practicality, and gauge student responses. Utilizing the ADDIE model, the research follows five stages: Analysis, Design, Development, Implementation, and Evaluation. In the Analysis stage, a literature review was conducted to identify critical components, including formative assessment, conceptual scaffolding, concept mastery, and previous research. The Design stage involved identifying users, defining competencies and indicators, creating a storyboard, integrating assessment components, and determining mastery levels. During the Development stage, the assessment media were developed into a functional product. …


Treating Type Ii Medial Tibial Stress Syndrome With Primal Reflex Release Technique: A Novel Approach, Shelli Green, Jenna Morogiello, Kurrel Fabian, James May, Alan Nasypany Dec 2024

Treating Type Ii Medial Tibial Stress Syndrome With Primal Reflex Release Technique: A Novel Approach, Shelli Green, Jenna Morogiello, Kurrel Fabian, James May, Alan Nasypany

Clinical Practice in Athletic Training

Five NCAA Division I cheerleaders (age 20 ± 1.4; 3 males, 2 females) presented with Medial Tibial Stress Syndrome (MTSS). Following an evaluation, all patients diagnosed with MTSS were treated using Primal Reflex Release Technique (PRRT). Immediate improvements in reported pain were demonstrated after one treatment. Improvements in perceived dysfunction were demonstrated after 4.2 (± 0.84) treatments over 15.4 (± 5.86) days with no time lost. All improvements were maintained at two-week follow-up. Type II MTSS patients treated with PRRT may experience an immediate, lasting reduction in pain, improvement in function, and shorter time to overall resolution.


A Descriptive Examination Of Perceived Stress And Coping Among Athletic Trainers Employed In The National Collegiate Athletic Association, Stephanie M. Singe, Elisabeth M. Mckenna, Alexandrya Cairns, Christianne Eason Dec 2024

A Descriptive Examination Of Perceived Stress And Coping Among Athletic Trainers Employed In The National Collegiate Athletic Association, Stephanie M. Singe, Elisabeth M. Mckenna, Alexandrya Cairns, Christianne Eason

Clinical Practice in Athletic Training

Time and work demands are high for the collegiatea athletic trainer, which can increase work stress and burnout may result. High perceived levels of stress and burnout can impact an athletic trainer’s mental health and wellness. Data were collected via an online descriptive, cross-sectional survey (Qualtrics) examining the perceived stress and coping strategies used among athletic trainers employed in the collegiate setting. Respondents completed the pereceived stress scale (ɑ=.90), and a series of close-ended questions related to their self-reported strategy of coping. Data was collected during September of 2022. We had 987 (men 371, women 607, did not disclose 9) …


Driving After A Concussion In Adolescents And Young Adults, What Is The Current Research And Consensus?, Melanie Kwok, Tamara Valovich Mccleod Dec 2024

Driving After A Concussion In Adolescents And Young Adults, What Is The Current Research And Consensus?, Melanie Kwok, Tamara Valovich Mccleod

Clinical Practice in Athletic Training

N/a


Comparison Of Patellar Taping And Strapping For Treating Patellofemoral Pain, Kaison Ames, Eric G. Post Dec 2024

Comparison Of Patellar Taping And Strapping For Treating Patellofemoral Pain, Kaison Ames, Eric G. Post

Clinical Practice in Athletic Training

Among collegiate athletes, patellofemoral pain (PFP) represents nearly one-third of all sport-related injuries. There have been multiple studies using a patellar tendon strap as an intervention to treat PFP that showed an improvement in knee pain, as well as studies showing improvement in knee pain when using patellar taping for PFP. However, there is very limited research written that compares the effectiveness of a patellar tendon strap versus a patellar tendon taping technique for patients with PFP. Therefore, the purpose of this study was to compare the effectiveness of patellar taping versus patellar strapping to reduce PFP in collegiate athletes. …


Thoracic Mobility And The Effects It Has On The Human Body: An Evidence To Practice Review, Megan Kurzec, Barton E. Anderson Dec 2024

Thoracic Mobility And The Effects It Has On The Human Body: An Evidence To Practice Review, Megan Kurzec, Barton E. Anderson

Clinical Practice in Athletic Training

Decreased thoracic mobility, stability, and strength are prevalent issues in athletes, contributing to various musculoskeletal problems. This Evidence to Practice Review synthesizes findings from a guiding systematic review that identified exercises targeting the thoracic spine in athletes. The review included a comprehensive search across six databases, five journals, and five social media platforms, yielding 38 exercises designed to improve thoracic mobility, motor control, work capacity, and strength. Despite the low level of evidence (Level D), these exercises are widely used in clinical practice. This review provides a framework for exercise prescription, offering athletic trainers a range of exercise options to …


Composite Volume Learning Media Based On Augmented Reality To Enhance Students’ Visual-Spatial Intelligence, Ria Kurniawati, Susiswo Susiswo, Syamsul Hadi Dec 2024

Composite Volume Learning Media Based On Augmented Reality To Enhance Students’ Visual-Spatial Intelligence, Ria Kurniawati, Susiswo Susiswo, Syamsul Hadi

Jurnal Pendidikan Sains

Augmented Reality (AR) technology, a three-dimensional visual tool that integrates virtual objects or environments into real-world displays in real time (Azuma et al., 2001), is particularly useful for grasping complex concepts such as the composite volume of solids, which often confuses students when they need to decompose solids into their individual components. While previous research has predominantly focused on the introduction of solids, spatial nets, and the volume of singular shapes, this study aims to develop composite volume learning media based on AR to enhance students’ visual-spatial intelligence in a valid, practical, and effective manner, aligning with their concrete operational …


Design Of Motivational-Realistic-Pancasila Learning In Mathematics, Marup Marup, Suradi Tahmir, Ahmad Talib, Nurzatulshima Kamaruddin Dec 2024

Design Of Motivational-Realistic-Pancasila Learning In Mathematics, Marup Marup, Suradi Tahmir, Ahmad Talib, Nurzatulshima Kamaruddin

Jurnal Pendidikan Sains

Learning mathematics in class greatly influences students' learning success both in terms of knowledge and attitudes. In carrying out learning, a learning design is needed that can foster student motivation so that they provide learning outcomes to the learning objectives. Motivational-Realistic-Pancasila learning design is considered to be an alternative solution. Morela is a design that combines motivational, realistic indicators and Pancasila values. The teaching of mathematics in the classroom significantly influences students' academic success, both in terms of knowledge and attitude. To effectively carry out the teaching process, a well-designed instructional approach is necessary to foster students' motivation to achieve …


Harnessing Natural Medicine As A Resource For Socioeconomic Development, Eneojo Ogu, Martins Emeje, Munira Abdullahi Dec 2024

Harnessing Natural Medicine As A Resource For Socioeconomic Development, Eneojo Ogu, Martins Emeje, Munira Abdullahi

Journal of Bioresource Management

Natural medicine is currently gaining global acceptance among the developed and developing countries of the world due to its low toxicity, high efficacy and cost effectiveness. Developed countries are devising medicinal systems that require the use of medicinal plant products and resources. Thus, a marked increase in world demand for medicinal plant resources has emerged in the recent years and that has provided a great opportunity for medicinal plants exporting nations to expand their economy shares in this sector. Despite the Nigeria immense socio-economic promise, the country is in critical need following the fact that the multidimensional poverty rate is …


Phytochemical Screening And Medicinal Properties Of Caralluma Fimbriata And Moringa Oleifera, Ammara Tariq, Anum Ashfaq, Kalsoom Sughra, Ayesha Hameed Dec 2024

Phytochemical Screening And Medicinal Properties Of Caralluma Fimbriata And Moringa Oleifera, Ammara Tariq, Anum Ashfaq, Kalsoom Sughra, Ayesha Hameed

Journal of Bioresource Management

The research was intended to evaluate the medicinal properties of Caralluma fimbriata and Moringa oleifera, as these plants are well known for their therapeutic activities. Qualitative analysis of the phytochemical components of these plants was used to identify the existence of potentially useful therapeutic compounds. Antibacterial and antifungal activities of extracts were assessed and their antioxidant and anti-inflammatory properties were evaluated using the DPPH assay and the protein denaturation inhibition assay, respectively. The α-amylase and α-glucosidase inhibition tests were utilized to determine the plant extract's effectiveness as an antidiabetic agent. Phytochemical analysis showed the presence of medicinally beneficial compounds …


Literacy Story Mapping: Empowering Bogoran Hamlet In Indonesia Through Among E3cho Program, Luky Tiasari, Shanta Rezkita, Vita Tri Wahyuni, Deyas Fito Nurochman, Annisa Hapsari, Dwi Setiawan Dec 2024

Literacy Story Mapping: Empowering Bogoran Hamlet In Indonesia Through Among E3cho Program, Luky Tiasari, Shanta Rezkita, Vita Tri Wahyuni, Deyas Fito Nurochman, Annisa Hapsari, Dwi Setiawan

ASEAN Journal of Community Engagement

This paper outlines the implementation of Among Education, Environment, Economic, Culture, Healthy, and Outcome (Among E3CHO), a community engagement program in Bogoran Hamlet in Trirenggo Region of Bantul Regency, Yogyakarta, Indonesia. Among E3CHO initiative consists of multiple education, environment, economic, culture, and health engagement sessions aimed at generating a literacy story map, Peta Cerita Berliterasi, as an integrated outcome of community capacities. The program development followed community-based research methodologies, starting with the identification of challenges facing by the community using comprehensive questionnaires, followed by multiple community engagement programs. In the program, the health …


Psychological Effects Of Number Of Knee Surgeries In Female Collegiate Soccer Athletes, Jun Yamada, Eric G. Post Dec 2024

Psychological Effects Of Number Of Knee Surgeries In Female Collegiate Soccer Athletes, Jun Yamada, Eric G. Post

Clinical Practice in Athletic Training

Psychological readiness is an important factor for returning to sport successfully following anterior cruciate ligament (ACL) reconstruction. To date, no studies have determined the effect of the number of knee surgery to psychological readiness. The primary purpose of this investigation was to determine whether the number of knee surgeries impacts psychological readiness. The secondary purpose was to examine the relationship between the number of surgeries and knee function. Data was collected from participants on the women’s soccer teams at a local division Ⅰ, Ⅲ, and NAIA college. Inclusion criteria were 1) currently fully participating in activities without any limitations, and …


Treating Chronic Low Back Pain And Plantar Fasciitis With Myokinesthetic System: A Case Study, Sadie Buboltz-Dubs, Russell Baker Dec 2024

Treating Chronic Low Back Pain And Plantar Fasciitis With Myokinesthetic System: A Case Study, Sadie Buboltz-Dubs, Russell Baker

Clinical Practice in Athletic Training

The purpose of this case study was to report the effects of the MyoKinesthetic (MYK) System on the pain and function of a collegiate softball player previously diagnosed with chronic non-specific low back pain and foot pain. The patient had been experiencing bilateral foot pain since childhood and conservative treatment options had failed to resolve her pain long term. Additionally, the patient had been experiencing persistent back tightness and soreness. Upon arrival at the university, the patient was evaluated using the MYK postural analysis to identify if a primary nerve root dysfunction could be the cause of her pain. The …


Supporting Mental Wellness In Transgender Athletes, Abaigeal C. Fields, Zachary K. Winkelmann Dec 2024

Supporting Mental Wellness In Transgender Athletes, Abaigeal C. Fields, Zachary K. Winkelmann

Clinical Practice in Athletic Training

N/a


A Review Of Automated External Defibrillator Considerations In Athletic Training, Bryana M. Mammana, Susan W. Yeargin, Zachary K. Winkelmann Dec 2024

A Review Of Automated External Defibrillator Considerations In Athletic Training, Bryana M. Mammana, Susan W. Yeargin, Zachary K. Winkelmann

Clinical Practice in Athletic Training

N/a


Correlation Between Pre-Season Single-Leg Hop Testing Data And Lower Extremity Injuries In Collegiate Soccer Players, Ashley Kuchenbuch, Justin M. Stanek Dec 2024

Correlation Between Pre-Season Single-Leg Hop Testing Data And Lower Extremity Injuries In Collegiate Soccer Players, Ashley Kuchenbuch, Justin M. Stanek

Clinical Practice in Athletic Training

Lower extremity injuries are very common in collegiate soccer athletes and often lead to long-term rehabilitation programs and a decline in the athlete’s overall quality of life. Using single leg hop tests to identify “at-risk” athletes before the competitive season begins could allow medical staff to implement injury prevention programs that could help reduce the incidence of lower extremity injuries throughout the season. The purpose of this study was to determine if data taken from single leg hop (SLH) testing could help predict lower extremity injuries in female collegiate soccer players. A convenience sample of twenty-one participants were chosen to …


Predicting Kidney Graft Function And Failure Among Kidney Transplant Recipients, Yi Yao, Brad C Astor, Wei Yang, Tom Greene, Liang Li Dec 2024

Predicting Kidney Graft Function And Failure Among Kidney Transplant Recipients, Yi Yao, Brad C Astor, Wei Yang, Tom Greene, Liang Li

Faculty, Staff and Student Publications

Background: Graft loss is a major health concern for kidney transplant (KTx) recipients. It is of clinical interest to develop a prognostic model for both graft function, quantified by estimated glomerular filtration rate (eGFR), and the risk of graft failure. Additionally, the model should be dynamic in the sense that it adapts to accumulating longitudinal information, including time-varying at-risk population, predictor-outcome association, and clinical history. Finally, the model should also properly account for the competing risk by death with a functioning graft. A model with the features above is not yet available in the literature and is the focus of …


Disruption Of Distal Appendage Protein Cep164 Causes Skeletal Malformation In Mice, Hiroyuki Yamaguchi, Megumi Kitami, Margaret Li, Sowmya Swaminathan, Radbod Darabi, Ken-Ichi Takemaru, Yoshihiro Komatsu Dec 2024

Disruption Of Distal Appendage Protein Cep164 Causes Skeletal Malformation In Mice, Hiroyuki Yamaguchi, Megumi Kitami, Margaret Li, Sowmya Swaminathan, Radbod Darabi, Ken-Ichi Takemaru, Yoshihiro Komatsu

Faculty, Staff and Student Publications

The primary cilium is a cellular antenna to orchestrate cell growth and differentiation. Deficient or dysfunctional cilia are frequently linked to skeletal abnormalities. Previous research demonstrated that ciliary proteins regulating axoneme elongation are essential for skeletogenesis. However, the role of the ciliary proteins responsible for initiating cilium assembly in skeletal development remains unknown. Here, we investigate the function of centrosomal protein of 164 kDa (CEP164), a key ciliogenesis regulator that localizes at the distal appendages of the mother centriole, during skeletal development in mice. Interestingly, the mesodermal cell-specific Cep164 deletion resulted in severe bone defects and osteoblast-specific deletion of Cep164 …


Implementation Of Patient Care Documentation Standard For Athletic Training Staff In Intercolle, Lucas Bianco, Maria Popek, Bri Durics, Christian Miles Dec 2024

Implementation Of Patient Care Documentation Standard For Athletic Training Staff In Intercolle, Lucas Bianco, Maria Popek, Bri Durics, Christian Miles

Clinical Practice in Athletic Training

Documentation is a professional standard for all health care professions. As part of a relatively young profession, athletic trainers have had to adjust to the expectations around documentation to stay at the same level as other health care providers. Documentation is often a highly discussed topic with more and more education sessions and resources being provided by NATA, BOC and NATA Research Education Foundation. The need for Continuous Quality Improvement projects and subsequent studies has continued to grow. Projects with a focus on documentation can be completed then disseminated to determine the most effective ways to improve documentation across our …


Women's Involvement In Fisheries Co-Management Of The World's Largest Desert Lake, Turkana, Kenya, Maurice O. Ogoma, Judith C. Koskey Dec 2024

Women's Involvement In Fisheries Co-Management Of The World's Largest Desert Lake, Turkana, Kenya, Maurice O. Ogoma, Judith C. Koskey

Journal of Bioresource Management

Despite their significant presence in the fisheries workforce, women's roles are often less recognized compared to men's. This study investigated the participation of women in beach management units (BMUs) and fisheries activities in Lake Turkana, the world’s largest permanent desert Lake. Data were collected from 200 women respondents across eight purposively sampled BMUs, focusing on gender representation, leadership roles, participation in fisheries activities, factors influencing participation, and strategies for promoting gender equity. Descriptive statistical analysis was conducted to provide an in-depth understanding of women's involvement in fisheries activities. Findings indicated that while gender representation aligned with Kenya's constitutional one-third gender …


Tourism Carrying Capacity At Petungkriyono Forest And Its Supporting Areas, Nurwidya Ambarwati Dec 2024

Tourism Carrying Capacity At Petungkriyono Forest And Its Supporting Areas, Nurwidya Ambarwati

Journal of Environmental Science and Sustainable Development

Supported by a variety of diversity and landscapes, the development of tourism in the Petungkriyono area is growing rapidly. Optimizing ecotourism services in the Petungkriyono forest without disrupting the ecosystem and damaging the environment can be done by limiting the number of visitors at tourism sites. This study aims to find out information about the tourism capacity of some tourist attractions in the local forest. This study uses the Cifuentes model to predict the maximum number of visitor capacities that can be accommodated in a tourist attraction called Physical Carrying Capacity (PCC), Real Carrying Capacity (RCC), and Effective Carrying Capacity …


Forecasting Air Pollution Driven By Vehicle Growth, Public Transport, Industry, And Household Waste, Chandra Harjono, Ludy Gianto, Rachmattullah Sidik, Dyah Lestari Widaningrum Dec 2024

Forecasting Air Pollution Driven By Vehicle Growth, Public Transport, Industry, And Household Waste, Chandra Harjono, Ludy Gianto, Rachmattullah Sidik, Dyah Lestari Widaningrum

Journal of Environmental Science and Sustainable Development

Jakarta, Indonesia's bustling capital, is grappling with escalating air pollution levels attributed to a confluence of socio-economic and infrastructural factors. This study employs Vensim modelling to project PM2.5 pollution trends through 2040, analysing the dynamic interplay among major contributors: increased vehicular emissions, industrial activities, public transportation deficiencies, and waste management inefficiencies. Materials and Methods: The method that will be used in this air pollution analysis is to integrate empirical data spanning three years to construct a predictive model underpinned by a robust causal loop diagram that elucidates the relationships between system variables and air quality. The results of this paper …


Black Soldier Fly Larvae (Bsfl) Bioconversion For Circular Economy: A Study In Polaman Village, Siswo Sumardiono, Rizka Amalia, Syaikha Butsaina Dhiya’Ulhaq, Nurika Nazilatul Ilmi, Hermawan Dwi Ariyanto Dec 2024

Black Soldier Fly Larvae (Bsfl) Bioconversion For Circular Economy: A Study In Polaman Village, Siswo Sumardiono, Rizka Amalia, Syaikha Butsaina Dhiya’Ulhaq, Nurika Nazilatul Ilmi, Hermawan Dwi Ariyanto

ASEAN Journal of Community Engagement

Conventional organic waste management methods often lead to environmental degradation and underutilization of valuable resources. In rural areas, such as Polaman Village, limited awareness and inefficient disposal systems exacerbate these issues, thus necessitating innovative and sustainable solutions. This study explores black soldier fly larvae (BSFL) bioconversion as a community-based solution for organic waste management, addresses environmental challenges, and promotes economic empowerment by converting waste into valuable by-products. The study employed a mixed-methods approach, beginning with baseline assessments of waste generation and existing management practices to identify community needs. Educational workshops and hands-on training sessions introduced BSFL bioconversion techniques to local …


Assessing The Environmental Impact Of Municipal Solid Waste, Ojo Oluwayinka Florence, Olaniyan Olatunji Sunday, Akolade Adebola Saheed, Alabi Oluwaseyi Omotayo, Olaomotito Precious Adesope, Adebayo Kehinde John Dec 2024

Assessing The Environmental Impact Of Municipal Solid Waste, Ojo Oluwayinka Florence, Olaniyan Olatunji Sunday, Akolade Adebola Saheed, Alabi Oluwaseyi Omotayo, Olaomotito Precious Adesope, Adebayo Kehinde John

Journal of Environmental Science and Sustainable Development

Municipal solid waste (MSW) management presents significant environmental challenges, especially with increasing urbanization and population growth. This study assesses the environmental impacts of MSW, focusing on waste composition, management practices, and their effects on air, water, and soil quality. The primary objective is to evaluate how MSW contributes to environmental degradation and to explore strategies for mitigating these impacts. A hypothesis was developed that optimizing waste composition through proper sorting and treatment can reduce the environmental footprint of MSW management by at least 10% in terms of leachate production and greenhouse gas emissions. Samples were collected using a randomized sampling …


Sustainable Practices And Green Marketing In Healthcare Sector: Visual Trends And Future Insight, Muhammad Alfarizi, Lissa Rosdiana Noer Dec 2024

Sustainable Practices And Green Marketing In Healthcare Sector: Visual Trends And Future Insight, Muhammad Alfarizi, Lissa Rosdiana Noer

Journal of Environmental Science and Sustainable Development

The healthcare sector faces critical challenges, including climate change, rising healthcare demands, and resource inefficiencies, making sustainability a priority. This study investigates the integration of sustainable practices and green marketing within the healthcare sector using a bibliometric analysis of 194 journal articles published from 2015 to 2024. Key research questions explore evolving trends, thematic areas, and gaps in the literature to address sustainability issues. The study employs a rigorous five-phase bibliometric methodology, utilizing Scopus database data and tools like Bibliometrix and VOSViewer to identify key themes and relationships. The research demonstrates an annual growth rate of 56.24%, reflecting the rising …


A Bayesian Pharmacokinetics Integrated Phase I-Ii Design To Optimize Dose-Schedule Regimes, Mengyi Lu, Ying Yuan, Suyu Liu Dec 2024

A Bayesian Pharmacokinetics Integrated Phase I-Ii Design To Optimize Dose-Schedule Regimes, Mengyi Lu, Ying Yuan, Suyu Liu

Faculty, Staff and Student Publications

The schedule of administering a drug has profound impact on the toxicity and efficacy profiles of the drug through changing its pharmacokinetics (PK). PK is an innate and indispensable component of the dose-schedule optimization. Motivated by this, we propose a Bayesian PK integrated dose-schedule finding (PKIDS) design to identify the optimal dose-schedule regime by integrating PK, toxicity, and efficacy data. Based on the causal pathway that dose and schedule affect PK, which in turn affects efficacy and toxicity, we jointly model the three endpoints by first specifying a Bayesian hierarchical model for the marginal distribution of the longitudinal dose-concentration process. …


Neurofilament Light Chain In Serum Of Cancer Patients With Acute Neurological Complications, Amulya Gottiparthy, Keng Lam, Suprateek Kundu, Zixi Yang, Ivo Tremont-Lukats, Sudhakar Tummala Dec 2024

Neurofilament Light Chain In Serum Of Cancer Patients With Acute Neurological Complications, Amulya Gottiparthy, Keng Lam, Suprateek Kundu, Zixi Yang, Ivo Tremont-Lukats, Sudhakar Tummala

Faculty, Staff and Student Publications

Aim: Neurofilament light chain (NfL) is a nonspecific sensitive biomarker of axonal damage.

Methods: This case series identified cancer patients with neurological complications who had serum NfL measurements and paired these results to outcomes.

Results: NfL serum levels were available in 15 patients with hematological malignancies or solid tumors. The neurological complications studied were immune effector cell-associated neurotoxicity syndrome, immune checkpoint inhibitor-related encephalopathy, anoxic brain injury, Guillain-Barre syndrome, hemophagocytic lymphohistiocytosis, transverse myelitis, paraneoplastic syndrome, central nervous system demyelinating disorder and chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. All patients but one with serum NfL >900 pg/ml died …


Survey And Comparative Analysis Of Pollinator Diversity, Abundance, And Foraging Activity Of Diptera And Hymenoptera In Selected Habitats Of South Texas, Melissa Villarreal Dec 2024

Survey And Comparative Analysis Of Pollinator Diversity, Abundance, And Foraging Activity Of Diptera And Hymenoptera In Selected Habitats Of South Texas, Melissa Villarreal

Theses and Dissertations

With the declining bee population, non-bee pollinators can serve as an alternative source for pollination. Diptera is a potential source of untapped pollinator resources based on their abundance and visitation rate, but they are understudied in the field of pollination ecology. This study aimed to characterize the pollinator community in selected areas of South Texas. It focused on the Diptera and Hymenoptera families to compare their diversity, relative abundance, foraging behaviors, environmental influences, and vegetation associations. Active sampling and line transect were used in the survey to sample the Hymenoptera and Diptera communities to their family taxonomic rank. Statistical analyses …