Life Sciences Commons^™

Linking Water Quality And Climate Change To Long-Term Trends In Species Abundance In Norwalk Harbor, Viktoria Savatorova, Aidan Kieft, Nicole C. Spiller, Kasey Burns

Spora: A Journal of Biomathematics

This study examines the effects of environmental changes on fish populations in Norwalk Harbor, focusing on winter flounder (Pseudopleuronectes americanus), cunner (Tautogolabrus adspersus), northern pipefish (Syngnathus fuscus), and naked goby (Gobiosoma bosci) as examples of species responding to climate-related shifts. We analyze how water temperature, salinity, and dissolved oxygen correlate with fish abundance. To assess statistically significant differences in catch per unit effort (CPUE) across harbor regions, we applied the Kruskal-Wallis test followed by Dunn's post-hoc test. Seasonal variations in CPUE were examined by comparing monthly catch data for each species. K-means …

Shielding The Skull: Exploring The Influence Of Facial Protection, Impact Location And Neck Stiffness On Hockey Helmet Safety During A Linear Impact, Leigh Jeffries, Dr.Meilan Liu, Dr. Paolo Sanzo, Dr. Eryk Przysucha, Dr. Carlos Zerpa

International Journal of Exercise Science

International Journal of Exercise Science 18(7): 343-362, 2025. https://doi.org/10.70252/REVL1750 Originally designed to mitigate skull fractures and traumatic brain injuries in hockey players, hockey helmets have now become a critical focus for further research due to the rise in mild traumatic brain injuries. With the sport's evolution introducing stronger and faster players, new approaches that incorporate facial shielding in helmet technology and enhance athletes’ neck strength are needed to reduce concussion risks. This study pursued two primary objectives. Firstly, it sought to determine if a hockey helmet's stiffness fluctuated at different contact locations during static compression with the inclusion of facial …

Guanine Nucleotide Biosynthesis Blockade Impairs Mll Complex Formation And Sensitizes Leukemias To Menin Inhibition, Xiangguo Shi, Minhua Li, Zian Liu, Jonathan Tiessen, Yuan Li, Jing Zhou, Yudan Zhu, Swetha Mahesula, Qing Ding, Lin Tan, Mengdie Feng, Yuki Kageyama, Yusuke Hara, Jacob J Tao, Xuan Luo, Kathryn A Patras, Philip L Lorenzi, Suming Huang, Alexandra M Stevens, Koichi Takahashi, Ghayas C Issa, Md Abul Hassan Samee, Michalis Agathocleous, Daisuke Nakada

Faculty, Staff and Student Publications

Targeting the dependency of MLL-rearranged (MLLr) leukemias on menin with small molecule inhibitors has opened new therapeutic strategies for these poor-prognosis diseases. However, the rapid development of menin inhibitor resistance calls for combinatory strategies to improve responses and prevent resistance. Here we show that leukemia stem cells (LSCs) of MLLr acute myeloid leukemia (AML) exhibit enhanced guanine nucleotide biosynthesis, the inhibition of which leads to myeloid differentiation and sensitization to menin inhibitors. Mechanistically, targeting inosine monophosphate dehydrogenase 2 (IMPDH2) reduces guanine nucleotides and rRNA transcription, leading to reduced protein expression of LEDGF and menin. Consequently, the formation and chromatin binding …

Thriving Hives: Propolis - Harvest And Usage, Brynn Meredith, Teresa Hunsaker, Andree' Walker Bravo

All Current Publications

One of the lesser-known substances produced by honeybees is something called propolis. Propolis is a type of adhesive that bees use to construct their hives and keep unwanted invaders out. Propolis is difficult to collect and process but can be beneficial, as it has many useful applications. This fact sheet addresses harvesting and using propolis.

Hatching And Caring For Chicks, Cory Farnsworth, Jacob Hadfield, Ashley Longmore

All Current Publications

There are many reasons people are interested in raising birds. Most people who desire to start are interested in saving money and becoming more self-sufficient. Many people find excitement in hatching eggs and raising chicks. This fact sheet will help you get started with hatching eggs and raising chicks.

Using Thermal Camera Drones In Beef Cattle Roundup, Justin Wyatt Clawson, Eric Galloway, Shalyn Drake, Shawn Barstow, Ross Israelsen, Michael Pate

All Current Publications

Using drones with thermal sensors can be an effective tool in finding and collecting livestock from summer mountain ranges in the West. Drones can complete searches in much less time than required on horseback in demonstrated areas. Using drones reduces the workload of the rider and horse, saving time and energy and reducing the risk of injury. With proper training and certification, livestock producers can use drones to locate cattle and perform many other cost-cutting operations.

Predicting The Suitable Habitats Of Alosimus Marginicollis (Haag-Rutenberg, 1880) (Coleoptera: Meloidae) And Evaluating Its Potential Distribution In Relation To Geographical And Climatic Barriers, Muhammed Ari̇f Demi̇r, Mahmut Kabalak

Turkish Journal of Zoology

The main objective of this study was to predict the ecological requirements of Alosimus marginicollis (Haag-Rutenberg, 1880), for which limited ecological information is available, and to predict possible suitable habitats under current conditions and different future scenarios. An ensemble model-based approach, combining multiple algorithms (GAM, GLM, MARS, MaxEnt), was used to predict suitable habitats for this species using bioclimatic, topographic and land cover variables. The models indicated that the elevation variable among the topography variables, BIO15 (precipitation seasonality) and BIO4 (temperature seasonality) among the bioclimatic variables, and the cropland variable (cultivated and managed vegetation cover) among the land cover variables …

Morphological, Linear, And Geometric Morphometric Differences (Skull, Mandible, And Pelvis) Among Subspecies Of Talpa Levantis (Eulipotyphla: Talpidae) With Molecular Divergence (Mtdna And Nuclear Dna), Ahmet Yesari̇ Selçuk, Alaetti̇n Kaya, Haluk Kefeli̇oğlu

Turkish Journal of Zoology

In this study, we conducted comprehensive analysis to determine the morphological, linear morphometric, and geometric morphometric differences between three subspecies of Talpa levantis: T. levantis levantis, T. levantis dogramacii, and T. levantis transcaucasica. Molecular analyses including mitochondrial DNA (complete cyt b gene) and nuclear DNA (BRCA-2) were also used. The subspecies of T. levantis showed similarities in the parastyle of the first upper molar and the mesostyle of the second and third upper molars, as well as in the morphology of the pelvis and linear measurements of the ventral skull, mandible, and pelvis. T. levantis dogramacii and T. levantis levantis …

Raising Awareness About Hydrographic Careers Through Sea-Going Opportunities, Juliet Kinney, Rochelle Wigley, Sara Cardigos, Fahima Bellabad, Larissa Marques Freguette

Center for Coastal and Ocean Mapping

There is a worldwide shortage of hydrographic personnel (van Wegen, 2021, Hydro International 2008).  Calls for action to address this issue include the IHO’s Hydrography at Sea opportunities, while intiatiative such as Seabed 2030 are bringing broader attention to the field and helping to catalyze new discussions and partnerships in hydrography (IHO, 2024).  The global sea floor mapping community needs to develop a broader workforce pipeline.  We would like to highlight the importance of providing time at sea and leadership opportunities in developing a robust workforce.  We start with an overview of a selection of current exchange and training programs …

Adiporon, Adiponectin Receptor Agonist, Exhibits Antiproliferative And Apoptotic Effects In Ht29 And Hct116 Colon Cancer Cells, Arwa Fairaq, Ashraf N. Abdalla, Alanood S. Algarni, Yosra Alhindi

Saudi Toxicology Journal

AdipoRon is the first synthetic analog of endogenous adiponectin, which is an adipose tissue derived hormone. As it is characterized with pharmacological properties like adiponectin through binding and activating AdipoR1 and AdipoR2 receptors this makes it a target for therapeutic treatments for a multitude of disorders. In this study AdipoRon effect on HT29 and HCT116 colon cancer cells were investigated. Cytotoxic activity of AdipoRon was observed, with a significant inhibition rate in HT29 and HCT116 cells. Moreover, there was a significant decrease in the number of HCT116 colonies by clonogenicity test. In addition, cell migration assay showed significant decrease in …

Near-Infrared Fluorescence Imaging With An Met-Targeting Probe For Biopsy Site Selection In Patients With Oral Potentially Malignant Disorders, Jingbo Wang, Xuemin Shen, Qifan Ma, Lin Yang, Xiaoyu Zhou, Luting Wang, Junqi Cui, Chunye Zhang, Guojun Li, Neil Gross, Siyi Li, Ruimin Huang, Changyou Zhan, Zhen Cheng, Kun Wang, Jie Tian, Ying Yuan, Xiaofeng Tao

Faculty, Staff and Student Publications

Accurate detection of malignant transformation in oral potentially malignant disorders (OPMDs) is crucial for guiding effective treatment and improving patient management. This study evaluates the potential of MET-binding peptide-indocyanine green (cMBP-ICG), a mesenchymal-epithelial transition factor (MET)-targeted near-infrared fluorescence imaging (NIRFI) probe, for biopsy site selection in OPMDs. Preclinical results demonstrate the superior accuracy of NIRFI-assisted biopsy over conventional oral examination (COE)-based biopsy in detecting high-grade dysplasia (HGD) or squamous cell carcinoma (SCC) and reducing missed detection rates. In a clinical trial with 50 patients, NIRFI-assisted biopsy achieves significantly higher diagnostic accuracy compared to COE-based biopsy (91% vs. 72%, p = …

Did Raja Asterias Ever Occur In The Sea Of Marmara Or Were Previous Records Just Cases Of Misidentified Raja Clavata?, Hakan Kabasakal, Uğur Uzer, Fi̇rdes Saadet Karakulak

Turkish Journal of Zoology

The current inventories of elasmobranchs in the Sea of Marmara have some taxonomic problems that need to be solved. One problematic species in the elasmobranch fauna of the region is Raja clavata Linnaeus, 1758, and atypically coloured specimens of this skate species may have been misidentified in the past as congeners or closely related species. The present results show that R. asterias may be a misidentified species of the family Rajidae due to confusion with the atypically coloured R. clavata. As taxonomy is central to the integration of data sources in the context of biodiversity research and management of any …

Integrative Taxonomy Reveals The Existence Of A New Species Of Fat-Tailed Scorpions, Androctonus (Buthidae), In Iran, Hossein Barahoei, Omid Mirshamsi, Masoumeh Amiri, Asma Moeinadini, Ehsan Rakhshani

Turkish Journal of Zoology

Two species of Androctonus have been reported to date from Iran: Androctonus crassicauda (Olivier, 1807) and A. sistanus Barahoei and Mirshamsi, 2022, which is distributed only in the southeast of Iran. Investigating and identifying the distribution range of dangerous species is critically important for scorpion management. A total of 105 specimens of Androctonus were collected from representative locations in Esfahan, Yazd, Kerman, Hormozgan, Hamadan, and Khuzestan provinces. These samples were studied morphologically, morphometrically, molecularly (COI gene sequencing), and through species distribution modeling (SDM) using the MaxEnt model. Four Androctonus species were identified through the morphological and molecular studies: A. crassicauda, …

Icos-Expressing Car-T Cells Mediate Durable Eradication Of Triple-Negative Breast Cancer And Metastasis, Shelley Herbrich, Mehdi Chaib, Padmanee Sharma

Faculty, Staff and Student Publications

Triple-negative breast cancer (TNBC) remains one of the most aggressive and therapeutically challenging breast cancer subtypes. In their recent study, Cao et al introduced a B7H3-specific chimeric antigen receptor (CAR)-T cell with constitutive inducible co-stimulator (ICOS) expression (ICOS-B7H3-CAR-T), which demonstrated eradication of TNBC, including metastases, in preclinical models. These CAR-T cells exploit the expression of ICOS ligand on TNBC cells, enhancing antitumor cytotoxicity through ICOS signaling. Compared with conventional B7H3-CAR-T cells, the ICOS-B7H3-CAR-T cells exhibited superior antitumor efficacy, increased cytokine secretion, and prolonged survival in xenograft murine models. This study highlights ICOS as a promising co-stimulatory molecule for improving CAR-T …

Mathematical Modeling To Address Questions In Breast Cancer Screening: An Overview Of The Breast Cancer Models Of The Cancer Intervention And Surveillance Modeling Network, Oguzhan Alagoz, Jennifer L Caswell-Jin, Harry J De Koning, Hui Huang, Xuelin Huang, Sandra J Lee, Yisheng Li, Sylvia K Plevritis, Swarnavo Sarkar, Clyde B Schechter, Natasha K Stout, Amy Trentham-Dietz, Nicolien Van Ravesteyn, Kathryn P Lowry

Faculty, Staff and Student Publications

The National Cancer Institute-funded Cancer Intervention and Surveillance Modeling Network (CISNET) breast cancer mathematical models have been increasingly utilized by policymakers to address breast cancer screening policy decisions and influence clinical practice. These well-established and validated models have a successful track record of use in collaborations spanning over 2 decades. While mathematical modeling is a valuable approach to translate short-term screening performance data into long-term breast cancer outcomes, it is inherently complex and requires numerous inputs to approximate the impacts of breast cancer screening. This review article describes the 6 independently developed CISNET breast cancer models, with a particular focus …

First Record Of Nesting Ecology And Tumor-Forming Disease In Endangered Green Turtles (Chelonia Mydas) On Taiping Island, Taiwan, Tsung-Hsien Li, Po-Yu Wu, Ming-An Tsai

The Thai Journal of Veterinary Medicine

Taiping Island is an important sea turtle nesting site in Taiwan. However, information on the nesting ecology on Taiping Island is still limited. The present study was conducted between 26 April and 3 June 2023 with the objective of collecting primary data on the sea turtle species that nest on the island. A total of 20 individual nesting green turtles were identified. No other sea turtle species were recorded nesting during this period. Five percent of nesting sea turtles had external tumors. The mean curved carapace length of all nesting female turtles was 98.2 cm. A total of 28 clutches …

Genetic Associations With C-Peptide Levels Before Type 1 Diabetes Diagnosis In At-Risk Relatives, Taylor M Triolo, Hemang M Parikh, Mustafa Tosur, Lauric A Ferrat, Lu You, Peter A Gottlieb, Richard A Oram, Suna Onengut-Gumuscu, Jeffrey P Krischer, Stephen S Rich, Andrea K Steck, Maria J Redondo

Children’s Nutrition Research Center Staff Publications

Objective: We sought to determine whether the type 1 diabetes genetic risk score-2 (T1D-GRS2) and single nucleotide polymorphisms are associated with C-peptide preservation before type 1 diabetes diagnosis.

Methods: We conducted a retrospective analysis of 713 autoantibody-positive participants who developed type 1 diabetes in the TrialNet Pathway to Prevention Study who had T1DExomeChip data. We evaluated the relationships of 16 known single nucleotide polymorphisms and T1D-GRS2 with area under the curve (AUC) C-peptide levels during oral glucose tolerance tests conducted in the 9 months before diagnosis.

Results: Higher T1D-GRS2 was associated with lower C-peptide AUC in the 9 months before …

Exploring Profiles Of Fathers Integrating Food And Physical Activity Parenting Practices, John A Jimenez-Garcia, Louise C Mâsse, Robert L Newton, Salma M Musaad, Alicia Beltran, Teresia M O'Connor

Children’s Nutrition Research Center Staff Publications

Objective: This study aims to identify fathers' profiles integrating food parenting practices (FPP) and physical activity parenting practices (PAPP).

Design: We analysed cross-sectional data. The fathers completed the reduced FPP and PAPP item banks and socio-demographic and family dynamics (co-parenting and household responsibility) questionnaires. We identified fathers' profiles via latent profile analysis. We explored the influence of social determinants, child characteristics and family dynamics on fathers' profiles using multinomial logistic regression.

Setting: Online survey in the USA.

Participants: Fathers of 5-11-year-old children.

Results: We analysed data from 606 fathers (age = 38 ± 8·0; Hispanic = 37·5 %). Most fathers …

03.17.2025 Ored Connect, Liz Williamson

ORED Newsletter

SPA director Andrea Rich

ARC Nomination Deadline Extended

Neural Correlates Of Opioid-Induced Risk-Taking Behavior In The Prelimbic Prefrontal Cortex, Cana B Quave, Andres M Vasquez, Guillermo Aquino-Miranda, Milagros Marín, Esha P Bora, Chinenye L Chidomere, Xu O Zhang, Douglas S Engelke, Fabricio H Do-Monte

Faculty, Staff and Student Publications

Opioid use disorder occurs alongside impaired risk-related decision-making, but the underlying neural correlates are unclear. We developed an approach-avoidance conflict task using a modified conditioned place preference procedure to study neural signals of risky opioid seeking in the prefrontal cortex, a region implicated in executive decision-making. Following morphine conditioned place preference, rats underwent a conflict test in which fear-inducing cat odor was introduced in the previously drug-paired side of the apparatus. While the saline-exposed control group avoided cat odor, the morphine group included two subsets of rats that either maintained a preference for the paired side despite the presence of …

An Exosome-Based Liquid Biopsy Predicts Depth Of Response And Survival Outcomes To Cetuximab And Panitumumab In Metastatic Colorectal Cancer: The Exonerate Study, Caiming Xu, Alessandro Mannucci, Francis Esposito, Helena Oliveres, Vicente Alonso-Orduña, Alfonso Yubero, Carlos Fernández-Martos, Antonieta Salud, Javier Gallego, Marta Martín-Richard, Julen Fernández-Plana, Mónica Guillot, Jorge Aparicio, Marwan Fakih, Scott Kopetz, Jaime Feliu, Joan Maurel, Ajay Goel

Faculty, Staff and Student Publications

Purpose: The EXOsome and cell-free miRNAs of anti-EGFR ResistAnce (EXONERATE) study was an open-label, biomarker interventional study designed to develop, test, and validate a liquid biopsy predictive of progression-free survival (PFS), overall survival (OS), and objective response rate (ORR) for first-line EGFR inhibitors in metastatic colorectal cancer (mCRC).

Patients and methods: Patients with newly diagnosed RAS wild-type, chemotherapy-naïve mCRC, both right- and left-sided, were enrolled in two nationwide trials to receive cetuximab or panitumumab along with chemotherapy. The primary endpoint was 12-month PFS, which was hierarchically tested in left- and right-sided mCRCs to predict PFS, OS, and ORR.

Results: Genome-wide …

Ca-125 As A Biomarker In Renal Medullary Carcinoma: Integrated Molecular Profiling, Functional Characterization, And Prospective Clinical Validation, Sandra L Grimm, Menuka Karki, Kyle A Blum, Jean-Philippe Bertocchio, Rong He, Durga N Tripathi, Niki M Zacharias, Justin M Lebenthal, Rahul A Sheth, Priya Rao, Giannicola Genovese, Zhen Lu, Robert C Bast, Davis R Ingram, Rossana Lazcano, Khalida M Wani, Wei-Lien Wang, Alexander J Lazar, Nizar M Tannir, Cheryl L Walker, Cristian Coarfa, Pavlos Msaouel

Faculty, Staff and Student Publications

Purpose: Renal medullary carcinoma (RMC) is a highly aggressive malignancy defined by the loss of the SMARCB1 tumor suppressor. It mainly affects young individuals of African descent with sickle cell trait, and it is resistant to conventional therapies used for other renal cell carcinomas. This study aimed to identify potential biomarkers for early detection and disease monitoring of RMC.

Experimental design: Integrated profiling of primary untreated RMC tumor tissues and paired adjacent kidney controls was performed using RNA sequencing and histone chromatin immunoprecipitation sequencing. The expression of serum cancer antigen 125 (CA-125), was prospectively evaluated in 47 patients with RMC. …

Impact Of Co-Mutations And Transcriptional Signatures In Non-Small Cell Lung Cancer Patients Treated With Adagrasib In The Krystal-1 Trial, Marcelo V Negrao, Alvaro G Paula, David Molkentine, Laura Hover, Monique Nilsson, Natalie Vokes, Lars Engstrom, Andrew Calinisan, David M Briere, Laura Waters, Jill Hallin, Lixia Diao, Mehmet Altan, George R Blumenschein, Ferdinandos Skoulidis, Jing Wang, Scott E Kopetz, David S Hong, Don L Gibbons, Peter Olson, James G Christensen, John V Heymach

Faculty, Staff and Student Publications

Purpose: KRAS inhibitors are revolutionizing the treatment of non-small cell lung cancer (NSCLC), but clinico-genomic determinants of treatment efficacy warrant continued exploration.

Experimental design: Patients with advanced KRASG12C-mutant NSCLC treated with adagrasib [KRYSTAL-1 (NCT03785249)] were included in the analysis. Pretreatment next-generation sequencing data were collected per protocol. HTG EdgeSeq Transcriptome Panel was used for gene expression profiling. Clinical endpoints included objective response, progression-free survival (PFS), and overall survival (OS). KRASG12C-mutant NSCLC cell lines and xenograft models were used for sensitivity analyses and combination drug screens.

Results: KEAP1 MUT and STK11MUT were associated with shorter survival to adagrasib [KEAP1: …

Phase I Trial Of Tti-101, A First-In-Class Oral Inhibitor Of Stat3, In Patients With Advanced Solid Tumors, Apostolia M Tsimberidou, David J Vining, Sukeshi P Arora, Sofia De Achaval, Jeffrey Larson, John Kauh, Carrie Cartwright, Rony Avritscher, Imran Alibhai, David J Tweardy, Ahmed O Kaseb

Faculty, Staff and Student Publications

Purpose: Signal transducer and activator of transcription 3 is a transcription factor that is essential for the survival and immune sequestration of cancer cells. We conducted a phase I study of TTI-101, a first-in-class, selective small-molecule inhibitor of signal transducer and activator of transcription 3, in patients with advanced metastatic cancer.

Patients and methods: Patients were treated with TTI-101 orally twice daily in 28-day cycles at four dose levels (DL): 3.2 (DL1), 6.4 (DL2), 12.8 (DL3), and 25.6 (DL4) mg/kg/day ("3+3" design). Three TTI-101 formulations were used in a stepwise manner (NCT03195699).

Results: Sixty-four patients were treated (median …

Exploring The Therapeutic Potential Of Trigonella Foenum-Graecum Extract-Loaded Transferosomal Gel In Freund's Complete Adjuvant-Induced Rat Models., Vandana Singh Ms., Hema Arya Ms., Bhavana Singh Dr., Koushal Dhamija Mr., Preeti Singh Dr., Gautam Kumar Dr.

Chulalongkorn Medical Journal

Abstract:

Background: Rheumatoid arthritis (RA) is a debilitating autoimmune disorder characterized by inflammation and joint damage.

Objective: This study aimed to evaluate the antiarthritic activity of Trigonella foenum-graecum (TFG) Transferosomal gel in a Freund’s adjuvant-induced arthritic rat model and compare it with Diclofenac gel, a standard anti-inflammatory drug.

Methods: Arthritis was induced in rats by injecting a 0.1 mL (1mg/ml) CFA suspension into the left hind foot in the subplantar region, allowing them to develop arthritis for 21 days.

Results: Arthritis induction led to a significant increase in paw volume, indicative of inflammation. Treatment with both TFG-transferosomal gel and Diclofenac …

Transferability Of Soil Management Assessment Framework Indices To Detect Best Soil Management Strategies In Tropical Agroecosystems, Helen C.S. Amorium, Amanda Ashworth, Gerson L. Drescher, Mohkam Singh, Marcio R. Nunes

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Soil management assessment framework (SMAF) algorithms have not been validated for tropical soils, which can prevent proper SMAF-based soil health monitoring. This study tested SMAF's ability to detect soil health as affected by soil management practices in the Mid-South United States and Brazil for improving SMAF performance in tropical regions. Eleven SMAF studies published in Brazil (n = 166) and 56 from the Mid-South United States (n = 500) were compiled. Management groups were perennial (PER), no-till (NT), reduced tillage (RT), and conventional tillage (CT) systems. In the United States, SMAF soil quality index decreased as follows: PER >= RT …

Color Aberrations In Seven Bird Species In Costa Rica, Lucia Isabel Lopez, Jose Manuel Mora, Adrian Alvarado Rivera

Biology Faculty Publications and Presentations

Although there are 935 species of birds in Costa Rica, scientific reports of pigmentation abnormalities in this group are limited. Nevertheless, several cases have been recently documented, including Leucism, Ino mutation, Progressive Graying, Dilution, and two unusual color aberrations in a toucan and a motmot. Here we describe seven cases of color aberrations observed over a period of five years in native birds of Costa Rica. An Eastern Wood-Pewee Contopus virens and a White-collared Manakin manacus candei were Brown. A Scintillant Hummingbird Selasphorus scintilla and a Talamanca Hummingbird, Eugenes spectabilis, also showed a Brown mutation, however, these two cases may …

Awareness Of Aspirin’S Dual Role As An Anti-Cancer Agent And Anti- Thrombotic Agent And Its Association With Medication Adherence To Low-Dose Aspirin: A Cross-Sectional Study, Hadhyah N. Alabdali, Sarah S. Al- Harbi, Layan Z. Sharalahi, Yosra Z. Alhindi

Saudi Toxicology Journal

Background: Aspirin is known to be an effective antithrombotic agent. Multiple studies have been studying its effect on cancer as colorectal cancer. Aim: This study aimed to measure the Awareness of Aspirin's Dual Function as an Anti-Cancer Agent and Anti-Thrombotic among Residents of the Makkah region in the Kingdom of Saudi Arabia. Methods: A cross-sectional study was conducted involving 490 participants from the Makkah region. Data collection was achieved through a self-reported online questionnaire and distributed via social media platforms from period of November 2024 until January 2025. Results: Over 340 of the participants in this research have bachelor's degrees. …

An Experimental And Numerical Investigation On The Flexural Behavior Of Two-Way Slabs Reinforced By Hybrid Reinforcement Schemes, Mahmoud A. Zidan, Mohamed H. Makhlouf, A. S. Debaiky, Gamal I. K.

Mansoura Engineering Journal

This study examines the Characteristics of flexural behavior in a two-way slab reinforced with a hybrid combination of Glass Fiber Reinforced Polymer. (GFRP) and steel reinforcement. It determines the effectiveness of hybrid reinforcement and fiber addition in enhancing the flexural resistance of two-way reinforced concrete slabs. Researchers tested twelve reinforced concrete slabs and divided them into four groups. There were two control specimens: one steel-reinforced and one glass fiber-reinforced polymer (GFRP)-reinforced, for comparison with the hybrid specimens. The remaining specimens were reinforced using a combination of steel bars and GFRP bars, The study focused on three-parameter categories: reinforcement type (steel …

Construct Validity, Test-Retest Reliability, And Inter-Rater Objectivity Of The Swimming Competence Assessment Scale (Scas), Jon Sundan, Håvard Lorås, Monika Haga

International Journal of Aquatic Research and Education

This study aimed to investigate the construct validity, test-retest reliability, and inter-rater reliability of a newly developed and comprehensive instrument for assessment of children’s swimming competence. The Swimming Competence Assessment Scale (SCAS) consists of six consecutive test items (entry, swim on front, surface dive, float, swim on back and exit) that aligns with the Norwegian curricular standard of swimming competence. The exploratory factor analysis retained a unidimensional model, supporting one underlaying statistical dimension with acceptable internal consistency (α = 0.79). Intraclass correlation coefficients (ICCs) between test and retest ranged from .84 to .98, and .97 for the total score. Strong …