Life Sciences Commons^™

Automated Plant Morphological Assessment And Microbial Community Monitoring In Simulated Lunar Regolith, Collin R. Topolski

Doctoral Dissertations and Master's Theses

Upcoming lunar bases will need to leverage in-situ resources to ensure long-term sustainability and reduce mission costs. One key challenge is food production, which could be addressed by growing crops in lunar regolith-based substrates. However, lunar regolith lacks essential nutrients, requiring organic amendments to support continuous plant cultivation. This study examined the impact of manure-amended lunar regolith simulant on Mizuna mustard growth while assessing microbial community diversity and functionality. To support this effort, a custom software pipeline utilizing an open-source library, PlantCV, was developed to automatically track plant leaf area and height via image analysis. Results indicated that amended rhizosphere …

Graduate School Blog - April 2025 Volume 1, Cynthia Haynes

UofM Grad School Blog

The April 2025 UofM Graduate School Blog highlights a month full of events, stories, and celebrations, beginning with Dr. Deborah Tollefsen’s personal graduate school journey, shared during the “Is Graduate School Right for Me?” virtual workshop an inspiring narrative of resilience, mentorship, and finding purpose through education. This edition also spotlights Graduate Student Appreciation Week, featuring a robust lineup of events such as a virtual town hall, resume and job market workshop, student social and awards ceremony, study session, and social dinners all designed to support, celebrate, and connect the UofM graduate student community. With opportunities to hear from …

“Seeing Someone Like Me Succeed Made Me Believe I Could Too!”: Evaluating The Big-Sib & Little-Sib Mentorship Program At Swarthmore College, Lina Verghese , '25

Senior Theses, Projects, and Awards

This thesis evaluates the Bio Big Sib & Little Sib Mentorship Program in Swarthmore College’s Biology Department, a student-led initiative supporting racial/ethnic minority and first-generation, low-income (FLI) students. Launched in 2021, the program pairs upperclassmen with underclassmen to offer guidance, build community, and affirm student identity within a predominantly white, elite academic environment. Using a mixed-methods approach, combining qualitative interviews and survey data, this study examines the program’s effectiveness and long-term impact on student belonging, academic navigation, and identity development. Findings reveal that the program has become a vital support structure, helping participants access the “hidden curriculum” and fostering emotional …

Host Range And Efficiency Of Plating Determination Of Phages Infecting Caulobacter And Non-Caulobacter Species, Christopher Scott

Senior Theses

Seven bacteriophages were studied to determine their host range among Caulobacter and non-Caulobacter bacteria. Recently, Caulobacter-associated phages have been shown to have broader host ranges than previously believed. Thus, it is crucial to thoroughly verify the range of bacteria strains that these phages can infect. To understand the extent of each phage’s host range, phage lysates were spotted on bacterial lawns to determine whether lysis could occur. Host-range analyses in this project conclude that these Dolichocephalovirinae phages were able to infect multiple genera and species of host bacteria. Plating efficiency experiments were also conducted to compare the phage’s …

Cis-2-Decenoic Acid Modulation Of Vibrio Vulnificus Biofilms, Gracie K. Anderson

Senior Theses

Vibrio vulnificus is a marine bacterial pathogen perpetrating severe wound and gastrointestinal infections in humans. The growing incidence of V. vulnificus infections and the widening ecological range of the species, closely linked to climate change trends, draw attention to an increasing need for methods to combat V. vulnificus infections without further augmenting the threat of antimicrobial resistance. The results presented herein highlight the ability of an unsaturated fatty acid diffusible signal factor, cis-2-decenoic acid (CDA), to influence the behavior of biofilms formed by a virulent human isolate strain of V. vulnificus (ATCC 27562). Results indicated that joint treatment of biofilms …

Neutrophil Inflammatory Death Regulation By Bacterial Type Iii Secreted Effectors, Arianna D. Reuven

Dartmouth College Ph.D Dissertations

Yersinia and Pseudomonas use a T3SS to secrete effectors into host cells that inhibit phagocytosis and modulate immune responses, such as inflammasome activation. Inflammasomes promote the activation of the proinflammatory protease caspase-1. The activation of an inflammasome sensor in response to a signal or ligand initiates the assembly of the inflammasome leading to activation of caspase-1 which cleaves GSDMD and pro-inflammatory cytokines IL-1β and IL-18 into their mature forms. As neutrophils are recruited in large quantities to sites of infection, they are excellent candidates to drive inflammasome dependent responses. Neutrophils have been shown to produce multiple inflammasomes, like pyrin and …

Investigation Of The Effects Of The Peptidylarginine Deiminase Inhibitor Cl-Amidine On Apoptosis And Gene Expression In Ovarian Cancer, Victoria Walden

Longwood Senior Thesis Proposal

Peptidylarginine deiminases (PADs) are a family of enzymatic proteins responsible for the conversion of arginine and methylarginine residues to citrulline. This conversion is important for several key cellular processes including transcriptional gene regulation. Recently, a link has been established between overexpression of a particular PAD, PAD4, and the accelerated progression of both autoimmune diseases and cancers. Ovarian cancer exhibits heightened levels of PAD4 in affected cells. High levels of PAD4 are associated with the formation of neutrophil extracellular traps (NETs) that promote cancer metastasis, and downregulation of the p53 apoptotic pathway. Thus, it is important to explore inhibitors of PAD4. …

Eating The Fat Of The Land: The Work Of Coxiella Burnetii To Traverse Intracellular Lipid Landscapes, Charlie Porto

Theses & Dissertations

Coxiella burnetii is an obligate intracellular pathogen and the causative agent of Q fever in humans. With primary hosts in livestock ruminants, C. burnetii is endemic globally, presenting significant health risks to agricultural workers and herd health at large. Numerous wild animal reservoirs exist, increasingly threatened by expanding livestock ranges. Furthermore, with a low infectious dose through aerosol transmission, the CDC considers C. burnetii a potential bioweapon, though in humans a large amount of infections persist subclinically, occasionally progressing to pneumonia and hepatitis with chronic infections leading to endocarditis.

The parasitic life cycle of C. burnetii is biphasic, a small …

Meat, The Future: The Role Of Regulators In The Lab-Grown Revolution, Joseph B. Davault, Michael S. Sinha

All Faculty Scholarship

The United States is one of the largest consumers of meat globally. The production of meat contributes substantially to climate change due to the levels of greenhouse gasses emitted and the amount of land, water, feed, and other natural resources required to raise animals used for meat. Traditional meat production is another major source for the emergence of zoonotic diseases and antimicrobial-resistant pathogens. Nevertheless, Americans consume more meat now than at any time in the nation’s history.

Advocates for policy change aimed at addressing the risks associated with meat production have typically focused on reducing meat consumption, alternatives to meat, …

Evaluating 51 Years Of The High School Range Camp, Cory Farnsworth, Ashley Longmore, Eric Thacker

Outcomes and Impact Quarterly

Established in 1973 by Utah State University (USU) Extension and the Utah Society for Range Management, Utah’s high school Range Camp has provided students with immersive experiences in sustainable rangeland practices for over five decades. Survey findings revealed that the camp had a significant impact on the educational paths and careers of the youth. Many participants continued to apply what they learned, demonstrating the camp’s lasting impact. Ongoing efforts focus on improving data collection, monitoring FFA competition performance, and expanding recruitment. Range Camp effectively guides youth toward higher education and careers related to the range while promoting responsible rangeland management.

Cultivating Community And Commerce: A Summary Of The Statewide Social And Economic Impacts Of Utah Farmers Markets, Jaclyn Pace, Bryn Watkins, Roslynn Mccann, Steven Price

Outcomes and Impact Quarterly

Data collected from six markets throughout the market seasons between 2023 and 2024 highlights the transformative impact of Utah’s farmers’ markets on the state’s economy, health, and sense of community. According to market patrons, Utah’s farmers' markets are vital economic and social hubs supporting local agriculture, small businesses, and community well-being.

College Of Natural Sciences Newsletter, Spring 2025, College Of Natural Sciences

College of Natural Sciences Newsletters and Reports

Page 1 Dean's Message from Dr. Sen Subramanian
Page 2 Student Spotlights
Page 3 Kaushik honored, Three-Minute Thesis, & Ice Cores revealed
Page 4 Alumni Spotlight
Page 5 Day of Scholars
Page 6 Cyanide research, Record Research Expenditures, Adhikari awarded Miller Research Award
Page 8 Hanson Receives NSF Grant
Page 9 Snow Lab Research Team
Page 10 Faculty Awards
Page 11 Drone Day
Page 13 Khalaf Awarded Presidential Award

Acute Effects Of High-Intensity Functional Training On Cognitive Function, Kelvin Wu, Gary Guerra

Presentations - 2025

CrossFit, a high-intensity functional training program, has gained widespread popularity for its physical fitness benefits, but its acute effects on cognitive function are not well understood. This study investigated the immediate impact of a CrossFit workout on cognitive performance, compared to a resting condition. Twenty experienced CrossFit athletes participated in two conditions: (1) a 12-minutes high-intensity CrossFit session and (2) a resting session involving 12 minutes of seated magazine reading. Cognitive performance was assessed using a flanker task, measuring reaction time and response accuracy as indicators of cognitive processing and inhibitory control.

Results revealed significantly better performance in the flanker …

Playful Paws: Are There Sex Differences In Playfulness With Freshwater Otters?, Julianne Pena

Posters - 2025

Personality is crucial for understanding the lives of species because it affects how they survive, the way they move, reactions to diseases, and much more (Merrick & Koprowski, 2017; Wolf & Weissing, 2012). The importance of this research is to understand how biological sex may interact with otter personalities through social interactions amongst other otters, the physical world, and humans. Female and male otters vary in the way that they play, with males playing more rough than females (Green, 2000). Play, which is associated with rock juggling, decreases as otters mature (Alliston et al., 2020). Females used object play more …

Seasonal Changes In Gene Expression Of The Three Estrogen Receptor Subtypes In The Atlantic Croaker, Micropogonias Undulatus, Elena Mares

Posters - 2025

Vertebrates have multiple estrogen receptor (ER) subtypes which facilitate transcriptional activity of genes when activated by estrogenic ligands. Teleost fish have 3 distinct estrogen receptor subtypes, including ERα, ERβ, and a unique type, ERγ. Each subtype has a different binding affinities to many estrogenic compounds, but their subsequent transcriptional regulatory mechanisms are not wellknown1. The focused species of the project is Micropogonias undulatus, the Atlantic Croaker.

Offering Alternatives To Biblical Literalism May Be The Key To Increasing The Public’S Acceptance Of Evolution, Jamie Jensen, Dalton Bourne, Kenneth Harrington, Grant Rousseau, Jessica Abele, Daniel Ferguson

ScholarsArchive Data

These are data from two cohorts: a nationwide dataset, and a BYU-specific student dataset. We gathered information on evolution acceptance (using the I-SEA), biblical literalism (using the EALS) and religiosity (using the Sethi and Seligman instrument).

Is Less More, Or More Better? Behavioral Insights From Bottlenose Dolphins During Dolphin Interaction Programs, Megan E. Davis, Alicia Virthe, Heather Manitzas Hill, Kathleen Dudzinski, Michelle Samm, Buck Lyman, Kelly Flaherty Clark, Todd Robeck

Posters - 2025

This poster was created for the 5th annual Research Showcase. From the poster:

Using video recordings collected during randomly selected human-dolphin interaction programs (2022-2023), 19 target dolphins were assessed for their behavioral repertoire, correct and incorrect responses to trainer/guest-given cues, and the total number of unique requested behaviors.

Obstacles And Opportunities In Marine Mammals Care And Welfare: Insights From Trainers, Alicia Virthe, Heather Manitzas Hill, Sabrina Brando

Posters - 2025

This poster was created for the 5th annual Research Showcase. From the poster:

The aims of the study included:

Identifying obstacles faced by caregivers

Exploring beliefs hindering the promotion of animal care and welfare

Highlighting the opportunities that caregivers perceive to maintain and enhance animal welfare and care

Do Otters Remember What They Solved? Manyotters - Collaborative Science, Manyotters, Heather Manitzas Hill, Deirdre Yeater, Caroline M. Delong, Catina Wright, Emily Langdon, Lisa Halstead

Posters - 2025

This poster was created for the 5th annual Research Showcase. From the Poster:

The ManyOtters group seeks to promote studies with larger sample sizes and a variety of species of otters, while developing a collaborative network of scientists. ...

Our initial project focuses on long term memory in otters.

For more information about ManyOtters please visit

https://manyotters.github.io/

Many Otters Project - Coding Analysis Of Otter Behavior With Foraged Puzzles, Isaiah Charles, Andres Vega

Posters - 2025

The study of long-term memory and the cognitive abilities of otters is not extensively documented. This research consisted of the use of foraging puzzles, which are different containers with food inside such as fish, squid, and oysters. This research project, named ManyOtters, takes inspiration from the foraging puzzle techniques exhibited in separate studies (e.g., Saliveros et al., 2022; Ladds et al. 2017). Based on the studies, foraging puzzles have shown to draw engagement for several otter species. The species focused on in this study were Asian small-clawed otters (Aonyx cinereus) and African spotted-necked otters (Hydrictis maculicollis) housed at SeaWorld San …

Think Like An Otter: Behavioral Problem-Solving In Fresh-Water Otters, Madison N. Vale, Miranda C. Ibarra

Posters - 2025

This study examines problem-solving in Asian Small-Clawed Otters (ASCOs), focusing on their cognitive processes during puzzle-solving tasks. The sample included two social groups of four otters: Eleanor and Dustin in one group, and Saki and Wonton in the other. Both groups were presented with a series of puzzles, and their responses were video recorded for coding. The relationship between sex and social learning was explored, but no significant findings were observed. Additionally, it was tested whether the number of strategies used and engagement duration predicted success; neither factor was a significant predictor. Overall, the results were inconclusive, offering no clear …

Understanding How Chaperones Influence Protein Aggregation, Hannah Buchholz

Dissertations (1934 -)

Cells depend on properly folded proteins to function and remain healthy. If proteins adopt a nonnative conformation, they may have an increased propensity to clump together or aggregate, which can compromise cell viability. Unwanted aggregates are linked to a class of diseases called proteinopathies, which include fatal disorders such as Alzheimer’s disease and amyotrophic lateral sclerosis (ALS). Fortunately, cellular factors, known as molecular chaperones, help maintain protein homeostasis by limiting and disassembling protein aggregates. However, the mechanisms that underlie how chaperones modify protein aggregation are poorly understood. The goal of this dissertation is to explore the molecular mechanisms used by …

Quality-Of-Care Measures For Cardio-Oncology: An Ic-Os And Acc Cardio-Oncology Leadership Council Perspective, Vijay U Rao, Anita Deswal, Daniel Lenihan, Susan Dent, Teresa Lopez-Fernandez, Alexander R Lyon, Ana Barac, Nicolas Palaskas, Ming Hui Chen, Hector R Villarraga, Diego Sadler, Courtney M Campbell, Kerry Skurka, Matt J Wagner, Matthias Totzeck, Kathryn J Ruddy, Paul Heidenreich, Randal Thomas, Daniel Addison, Sarju Ganatra, Richard Cheng, David Reeves, Arjun K Ghosh, Joerg Herrmann

Children’s Nutrition Research Center Staff Publications

This document serves as a perspective on quality assessments in the discipline of cardio-oncology. We aim to define the current landscape, identify needs for quality and outcome improvements, and propose a roadmap for establishing viable metrics to improve patient care. Specifically, this document: 1) addresses the current lack of measurable high-quality metrics in cardio-oncology and their implications; 2) highlights needs and topic-specific barriers; 3) illustrates the process and application of a measurable quality metric; and 4) provides a framework to demonstrate measurable value for the growing population of patients with cancer and cardiovascular diseases.

Demographic Clinical Trial Diversity Assessment Methods: Use Of Real-World Data, Hua Chen, Nnadozie Emechebe, Sudeep Karve, Leon Raskin, Jailene Leal, Ning Cheng, Wendy Sebby, Kim Ribeiro, Samuel Crawford

Children’s Nutrition Research Center Staff Publications

Diversity in clinical trials is defined by the inclusion of clinical trial participants from various demographic groups that are representative of the broader population impacted by a disease state. Diversity in clinical trials is critical in identifying potential differences in safety and efficacy of treatments across races, ethnicities, ages, sexes, or other variables. In the United States, clinical trial diversity is often benchmarked against US Census data, which may limit the representativeness of patient demographics in clinical trials. Disease-specific, demographic estimates from real-world data (RWD) can facilitate benchmarking of clinical trials, support trial enrollment and the development of trial diversity …

Novel Approaches To Analyze Consumer Behavior And Policies To Promote Sustainable Consumption, Bhagyashree Katare, Xuejian Wang, Shuoli Zhao, Jacqueline Yenerall

Agricultural Economics Faculty Publications

Technological advancements, such as online grocery shopping, have significantly transformed consumer retail environments and experiences. Effectively studying consumer behavior in these new environments requires the use of novel methodological approaches, which will also aid in developing interventions to encourage sustainable consumption. This paper begins by providing an overview of the current literature on novel approaches to analyzing consumer behavior, then provides an empirical application by examining consumer decision-making pathways within an online grocery shopping platform. Specifically, the paper focuses on exploring the consumers’ digital footprints, such as page visits, product additions and removals, and interactions with information labels to identify …

Ecological Studies Of Wolves On Isle Royale, Sarah R. Hoy, John A. Vucetich, Rolf O. Peterson

Ecological Studies of Wolves on Isle Royale

Annual Report 2024-2025

Lawn Nutrient Availability And Run-Off During Establishment Under Enhanced Biodiversity, Masami S. Kanyuk

Environmental Studies Honors Theses

Biodiversity has consistently been found to have positive ecosystem effects, including erosion mitigation and stability of nutrient cycling. For lawns, this can translate to reducing the need for fertilizer application, and reducing soil loss and leaching that can impact water quality. This paper investigates the effects of biodiversity and plant community establishment in a lawn ecosystem on soil erosion, nitrate leaching via porewater sampling, and plant available nitrogen.

In the first growing season of PLEDGE (the Pastures and Lawns Enhanced Drought and Global-Change Experiment), we hypothesized that three-species lawns (tall fescue, dwarf white clover, and creeping thyme) would experience higher …

Spring 2025, Humayun Islam

PMI Newsletter

No abstract provided.

What Do We Know About Insect Responses To Global Change? A Review Of Meta-Analyses On Global Change Drivers, Mayra C. Vidal, Mariana Abarca, Kristi Backe, Anne E. Curé, Deborah L. Finke, Amanda M. Koltz, Alycia C.R. Lackey, J. Christina Mitchell, Rebecca M. Prather, Ellen A.R. Welti, Gina M. Wimp, Shannon M. Murphy

Biological Sciences: Faculty Publications

1. Global change is causing major declines in biodiversity, especially of insects. Scientific interest in global change impacts on insects has increased in recent years, resulting in many different meta-analyses examining questions within this topic.

2. We performed a comprehensive review of meta-analyses examining the effects of global change stressors on insects to identify well-studied questions and gaps in our knowledge and synthesise the responses of insects to those stressors. We identified 75 meta-analyses that fit our scope, accounting for 905 meta-results and spanning 18 global change stressors.

3. Our synthesis identified several global change stressors that are relatively well-studied …

Coyote (Canis Latrans) Macronutrient Consumption And Diet Relative To Seasonality And Urbanization, Katherine C. B. Weiss, Sean C. P. Coogan, Pierre Deviche, Jesse S. Lewis, Savage C. Hess, Jan Schipper, Eric G. Strauss, Beckett Sterner

Biology Faculty Works

Diet selection informs the health, fitness, and behavior of wild predators. Due to assumptions that vertebrate prey contains similar compositions of macronutrients (i.e., protein, carbohydrates, and lipids), whole prey items traditionally define carnivore diets. However, increasing evidence suggests that prey differ in terms of their macronutrient compositions, particularly relative to body size. Furthermore, omnivorous predators, like coyotes (Canis latrans), integrate both prey and nonprey diet items whose macronutrient compositions vary. This is particularly important in urbanized systems, which introduce or alter the distributions of prey (e.g., domestic pets) and nonprey (e.g., ornamental plants) foods in ways that contribute …