Life Sciences Commons^™

Cognitive Outcomes In Prostate Cancer Treatment: Insights From The Odenza Trial And Future Considerations, Bryan J Neth, Jeffrey S Wefel, Kevin T Nead

Faculty, Staff and Student Publications

No abstract provided.

Trends In Medicare Payments Within The First Year Of Cervical Cancer Diagnosis, 2010–2019, Mohammad A Karim, Ning Zhang, Hui Zhao, Ya-Chen Tina Shih, Lakshmi S M Kodali, Sharon H Giordano, Sanjay Shete

Faculty, Staff and Student Publications

Assessing Medicare payment trends for cervical cancer care is important to mitigate the financial impact on Medicare. This multiyear cross-sectional study included 65 years and older cervical cancer patients in SEER registries diagnosed between 2010 and 2019 who had continuous Part A and B Medicare coverage at least 6 months before diagnosis and at least within the first year of diagnosis and were not enrolled in any Health Maintenance Organization (HMO) in this duration. The main outcomes were trends in total and service-specific mean monthly Medicare payments within the first year of a cervical cancer diagnosis. This study included 2147 …

Use Of Natural Language Processing To Identify Patients With Inflammatory Breast Cancer Across A Health-Care System, Ramez Kouzy, Megumi Kai, Huong T Le-Petross, Sadia Saleem, Wendy A Woodward

Faculty, Staff and Student Publications

Early identification and referral of inflammatory breast cancer remains challenging within large health-care systems, limiting access to specialized care. We developed and evaluated an artificial intelligence-driven platform integrating natural language processing (NLP) with electronic health records to systematically identify potential inflammatory breast cancer patients across 5 campuses. Our platform analyzed 8 623 494 clinical notes, implementing a sequential review process: NLP screening followed by human validation and multidisciplinary confirmation. Initial NLP screening achieved 55.4% positive predictive value, improving to 78.4% with human-in-the-loop review. Notably, among 255 confirmed patients with inflammatory breast cancer, our system demonstrated 92.2% sensitivity, identifying 57 patients …

Bilateral Germ Cell Tumor Of The Testis: Biological And Clinical Implications For A Stem Versus Genetic Origin Of Cancers, Jamaal C Jackson, Darren Sanchez, Aron Y Joon, Marcos R Estecio, Andrew C Johns, Amishi Y Shah, Matthew Campbell, John F Ward, Louis L Pisters, Charles C Guo, Miao Zhang, Niki M Zacharias, Shi-Ming Tu

Faculty, Staff and Student Publications

Germ cell tumors of the testis (GCTs) provide an ideal tumor model to investigate the cellular versus genetic origin of cancers. In this single institutional study, we evaluated 38 patients with bilateral GCT, including tumors that occurred simultaneously (synchronous) and those occurring at different times (metachronous). For nine of these patients, DNA was isolated from the right and left GCT to determine the genomic and epigenetic differences between tissues using whole-exome sequencing (WES) and reduced representation bisulfite sequencing (RRBS). We found that seminomas and non-seminomas are molecularly distinct based on DNA methylation and not due to synchronous or metachronous disease. …

Responsiveness Of Desert Plant Dehydrin Genes In The Alleviation Of Abiotic Stresses, Mughair Abdul Aziz

Thesis/ Dissertation Defenses

Dehydrins (DHNs) are hydrophilic, glycine-rich proteins that accumulate in vegetative tissues of plants in response to abiotic stress and during the late stages of seed maturation. In desert plants, these proteins likely contribute to their specialized adaptation under extreme environmental conditions. To examine the genetic mechanisms underlying DHN associated abiotic stress tolerance in desert plants, this study aimed to isolate them and investigate the architectural features and functional mechanisms related to them. It involved cloning of full-length cDNA sequences of DHN encoding genes, PcDHN1, CcDHN1, PdDHN1, and PdDHN2, from three desert plants Prosopis cineraria, Citrulus colocynthis, and Phoenix datcylifera, followed …

Can Assessment Of Morphometrics Correctly Predict Species In Madtoms?, Harley C. Walden

ATU Scholars Symposium

Species delineation is commonly achieved through genetic analyses, but the utility of morphometrics as an alternative method remains unclear. This study investigates whether morphometric measurements can effectively differentiate species in madtoms (Noturus spp.). A total of 10 morphometric traits were measured from 50 individuals each of three madtom species: the Slender Madtom (Noturus exilis), the Black River Madtom (Noturus maydeni), the Ozark Madtom (Noturus albater), the Ouachita Madtom (Noturus lachneri) and the Freckled Madtom (Noturus nocturnus). Random forest modeling was employed to identify which morphometric variables most accurately distinguish between …

Distribution Of Mussels In Two Intermittent Upland Streams Of The Arkansas Valley Ecoregion, Aaron A. Brady, Seth Drake, Zach Crain, Kendall Moles

ATU Scholars Symposium

Freshwater mussels are facing an increasing need for conservation due to their declining populations. More data is needed on mussel distributions, especially in tributaries of large rivers to properly conserve and restore populations. Big Shoal Creek and Little Shoal Creek are two upland-tributaries of the Arkansas River (Lake Dardanelle) in which no records exist for freshwater mussel populations. We addressed this knowledge gap by sampling a total of 9 sites in Little Shoal Creek and 18 sites in Big Shoal Creek to determine the abundance and distribution of mussels in these streams. Mussels were sampled using a timed search approach. …

Gathering A Population Assessment Of Endemic Ozark Longear Sunfish (Lepomis Sp. Ozark) In The Illinois Bayou Watershed, Kade Zeiner

ATU Scholars Symposium

The Ozark Longear Sunfish (Lepomis sp. Ozark) is a species endemic to the Ozark Highlands and Boston Mountains, primarily found in headwater streams that dry up in the summer. Their spawning period occurs from May to August, and because of the impact dry seasons have on water level in headwater streams, there's a possibility their population and health may be impacted. As an endemic species, they play a key role in their ecosystem, and their unique position makes them significant for both ecological and recreational reasons. Because of the wide variety of Sunfish species the state offers, new recreational challenges …

Gardens Through The Ages: How Public Gardens Impact The Growth Of Society, Abby J. Cutsinger

ATU Scholars Symposium

Throughout history, gardens held a vital role in the development of civilizations, often serving as spaces for food, reflection, and community. The aim of this study was to explore the progression of gardens parallel to Maslow’s hierarchy of needs. Additionally, the study aimed to determine whether gardens help fulfill those needs and, in doing so, influence human morality. To examine these possibilities, the researcher conducted a literature review of historical and contemporary accounts of gardening and its effects on physical and psychological well-being, analyzing these findings through the lens of Maslow’s framework. Additionally, crime rate data were compared across several …

Bibliometric Analysis Of Research Trends Related To Human Immunodeficiency Virus., Madyson E. Johnson, Kaitlyn R. Coffman, Valerie Rivas, Elizabeth Barrett

ATU Scholars Symposium

Human immunodeficiency virus poses major health burden across the globe including the United States of America and has its zoonotic origin from the Simian Immunodeficiency viruses of sooty mangabey monkey and chimpanzee in Africa. Epidemiological trends indicate that even though the mortality rates for HIV are falling globally, the rates of new cases have been rising since 2010 in several countries including the USA. An estimated 0.5% of the human population is currently infected with the virus with countries like USA, India, Nigeria and South Africa carrying the highest burden of the disease. Host receptors such as CD4 and coreceptors …

Discovering And Characterizing Novel Temperate Bacteriophage Infecting Arthrobacter Globiformis B-2979, Paige M. Baldwin, Michael Bennet, Evangelia A. Buonamici, Hanan E. Isik, Niran E. Isik, Vienna Li, Mia R. Mazakas, Aaryan M. Modi, Nikita Muppoor, Kylie A. Oliver, Vidhi M. Patel, Kylie Tabak, Jamie K. Yu, Laura Weber

STEM Student Research Symposium Posters

AmiCi24 is a novel temperate bacteriophage collected from a soil sample originating in Sewell, NJ, USA and cultivated with Arthrobacter globiformis B-2979. AmiCi24 is a Siphoviridae morphotype, belonging to the cluster AS and subcluster of AS3. The AmiCi24 genome consists of 38,466 basepairs, encoding 68 genes.

Evaluation Of Valid Vo2max Criteria For Graded Exercise Testing In Cancer Survivors, Daniel Y.K. Shackelford, Jessica M. Brown, Rhianna N. Patel

International Journal of Exercise Science

International Journal of Exercise Science 18(5): 443-455, 2025. Cardiovascular fitness (VO_2max) predicts all-cause mortality and is vital to assess in cancer survivors (CS) for individualized exercise prescriptions. Metabolic carts confirm VO_2max with respiratory exchange ratio (RER) >1.10; other VO_2max criteria include ≤10 beats/minute of maximal predicted heart rate and/or a rating of perceived exertion (RPE) of >8 on the Modified Borg Scale. Another suggested criterion is respiratory frequency (Rf) > 40 breaths per minute. These criteria are assumed applicable for all populations, but due to cancer-related toxicities, frequency and validity of traditional VO_2max criteria usage in …

Influence Of Biting Flies On The Growth And Condition Of Nestling Eastern Bluebirds, Ella Grace Bollinger

ATU Scholars Symposium

Habitat alteration and climate change are expected to increase the range, abundance, and season length of ectoparasites and the pathogens they carry. This is particularly concerning for nestling birds that are relatively naked and immobile, making them vulnerable to attacks by biting flies such as blackflies and mosquitoes. Despite the ubiquity of biting flies and the challenges they pose to nestlings, studies investigating their association with breeding birds remain rare. To address this, we propose a series of observational and experimental field studies with Eastern Bluebirds (Sialia sialis) to investigate the attraction of biting flies to active nests …

Investigating Silicon As A Candidate For Plant Synthetic Biology, Stephanie N. Nelms, Kai Herring, Luke Hanke, William Foley

ATU Scholars Symposium

The physicochemical properties of silicon are closely related to carbon. Certain species of plants accumulate high amount of silicon, however, their physiological role and molecular mechanism of sequestration and distribution in plant tissues are poorly understood. The bonding potential of silicon is analogous to carbon and silicon is a key element propelling nanotechnology and digital revolution. Recent discoveries of silicon in Mars and the Moon along with metabolic engineering of enzymes that can incorporate and cleave silicon from organic compounds have consolidated the idea of silicon-based synthetic cellular lifeforms. Bibliometric analysis was used to evaluate the trend of research in …

Using Guano To Determine Ozark Big-Eared Bat Cave Occupancy In Arkansas​, Lark E. Sybrant

ATU Scholars Symposium

The Ozark big-eared bat (Corynorhinus townsendii ingens) is endangered in Arkansas and is known to have small populations, range restrictions, and specific habitat requirements in the Ozark-St. Francis National Forest. Beyond their known range, there are other potentially suitable areas that have not been confirmed. We aim to test whether the non-invasive genetic analysis of guano samples can identify Ozark big-eared bat cave use and expand their known range. Additional locations need to be surveyed to ensure site protection, as unknown caves are susceptible to human disturbance and damage. Twenty-five sites were surveyed at the southeastern extent of their known …

Impact Of Community Gardening On Neighborhood Crime Rates: Research Proposal, Abby J. Cutsinger

ATU Scholars Symposium

Gardening has been a part of human existence from the beginning of time, but people have become distanced from gardening as civilization has grown and urbanized. As this distance has grown, so has the disconnect between people and the basic needs which shape their views of themselves and of society. It is possible that, in the drift away from gardening as communities, humans have become less moral.

The purpose of this study is to determine if community gardening lowers violent crime rates.

This relationship will be gauged by answering the following questions:

• Which type of community gardening benefits community relationships …

Using Environmental Dna To Evaluate The Distribution And Abundance Of Western Chicken Turtles, Kai D. Scarangella

ATU Scholars Symposium

The Western Chicken Turtle (Deirochelys reticularia miaria; WCT) is a Species of Greatest Conservation Need that is currently under review for federal listing and is assumed to be rare and declining across its range. WCT are threatened by a variety of anthropogenic challenges, including habitat loss, habitat modification, and road mortality. The conservation of this species is further hindered by a lack of understanding of its distribution, abundance, and population trends. These knowledge gaps arise largely from the species’ unique characteristics and cryptic nature. More specifically, WCT demonstrate prolonged aestivation and are notoriously difficult to capture. Environmental DNA …

Cellular And Molecular Mechanism Of Heavy Metal Phytoremediation, Kaitlin A. Edwards, Kayle Dacus, Autumn Wilbanks, Tatum Simms

ATU Scholars Symposium

Rapid urbanization and industrial activities have contributed to heavy metal contamination of several habitats thus leading to an emerging health and environmental challenge. Some heavy metals such as zinc, iron, molybdenum, manganese, copper, cobalt and nickel are found in trace amounts in biological organisms, however, most are harmful for cellular metabolism. Certain species of plants can accumulate large amounts of heavy metals and has been utilized to sustainably clean contaminated soil and water by a process called phytoremediation. Recent lab and field studies have reported promising results that could propel commercialization of this technology. The cellular and molecular mechanism involved …

Cloning The Yersinia Enterocolitica Alkaline Phosphatase For An Affinity Chromatography Ligand, Flavio E. Arellano

ATU Scholars Symposium

Alkaline phosphatase (ALP) is an enzyme responsible for the dephosphorylation of extra-cytoplasmic molecules. Conversion to a neutral molecule enhances their ability to pass through cell membranes. When microbes such as Yersinia enterocolitica are ingested, they are exposed to large changes in pH level. These changes range from ~pH6.5 in the oral cavity to pH 2 in the stomach and pH 8 in the mid-intestine. The ability of microorganisms to survive this change in pH it largely dependent on their ability to change which proteins are expressed at differing pH levels or their ability to modify those proteins to meet the …

Della Protein And Cbl-Cipk Signaling Pathway As Candidates For Genetic Engineering, Nathan F. Surles

ATU Scholars Symposium

No abstract provided.

Detecting Ideological Bias In Trump's Tweets: Trump's Peace Plan As A Case Study, Amer Qasem

Middle East Journal of Communication Studies

This study aims to explore the extent of ideological bias in the discourse of elected U.S. President Donald Trump on social media platforms, specifically Twitter (now known as X), regarding his peace plan, commonly referred to as the "Deal of the Century." The study employs Critical Discourse Analysis (CDA) to examine all of Trump’s tweets related to the Deal of the Century, seeking to answer the following research questions: How did Trump portray the parties affected by the deal in his tweets? What rhetorical strategies did he employ to present the deal? The analysis spans the period from the announcement …

The Use Of Artificial Intelligence Applications By Media Students In Palestinian Universities And Their Achieved Gratifications “A Field Study”, Said Shaheen Allani, Ahmad Al Sallaq

Middle East Journal of Communication Studies

The study aimed to identify the extent to which media students in Palestinian universities use artificial intelligence applications and the achieved gratifications from it. The study belongs to the descriptive studies approach utilizing questionnaire as a tool for collecting data, for an available sample of (165) individuals that were distributed in five Palestinian universities. The study reached to; (54.5%) of media students in Palestinian universities use artificial intelligence applications, they use it for several reasons, the most important phrase is “it helps me to produce good digital content,” with a relative weight of (47.4%), it also achieves a number of …

Media Frameworks In Addressing Environmental Issues On Al Jazeera Net Website: An Analytical Study, Sabah Al Harahsheh

Middle East Journal of Communication Studies

This study aimed to recognize the media frameworks used to address environmental issues on (Al Jazeera Net) between 2009 and 2024. The study relied on the descriptive survey method, the theory of media frames, and the content analysis as a method and tool. The study population consisted of all articles, reports and interviews published on the (Al Jazeera Net) throughout the period specified by the study. A purposive sample was selected from the articles, reports and interviews interested in environmental issues only, which numbered eighteen journalistic works. The study identified the most important frameworks that presented the environmental issues during …

The Mediating Role Of Remote Communication On The Relationship Between Electronic Human Resource Management Practices And Organizational Performance In Iraqi Commercial Banks, Shuhub Basel Ahmad Taqa

Middle East Journal of Communication Studies

This study aimed to measure the impact of remote communication as a mediating variable on the relationship between electronic human resources (e-HRM) and organizational performance in Iraqi commercial banks. The study adopted a descriptive-analytical approach, with the study population consisting of managers, their deputies, and department heads in Iraqi commercial banks, totaling 242 individuals distributed across 24 commercial banks by the end of 2023. A total of 234 questionnaires were analyzed, achieving a response rate of 96.7%. The study employed Smart PLS software for data analysis and result extraction. The study revealed several key findings, the most significant of which …

Neuroarts And Neuroaesthetics, James Hutson, Piper Hutson

Faculty Scholarship

Recent advancements in neuroarts and neuroaesthetics have elucidated the relationship between artistic engagement and neural processes, emphasizing the impact of aesthetic experiences on cognitive and emotional well-being. Central to this exploration is the NeuroArts Blueprint initiative, which consolidates interdisciplinary research to better understand the impactful role of the arts on brain function and health outcomes. Empirical studies highlight how exposure to art, such as music or visual stimuli, activates neural circuits involved in emotion regulation, memory, and reward processing, particularly engaging the medial orbitofrontal cortex. Innovations such as haptic and electro-tactile devices have introduced novel sensory modalities that not only …

Glycosylation Of Serine/Threonine-Rich Intrinsically Disordered Regions Of Membrane-Associated Proteins In Streptococci., Mohammad M Rahman, Svetlana Zamakhaeva, Jeffrey S. Rush, Catherine T Chaton, Cameron W Kenner, Yin Mon Hla, Ho-Ching Tiffany Tsui, Vladimir N Uversky, Malcolm E Winkler, Konstantin V Korotkov, Natalia Korotkova

Molecular and Cellular Biochemistry Faculty Publications

Proteins harboring intrinsically disordered regions (IDRs) lacking stable secondary or tertiary structures are abundant across the three domains of life. These regions have not been systematically studied in prokaryotes. Here, our genome-wide analysis identifies extracytoplasmic serine/threonine-rich IDRs in several biologically important membrane-associated proteins in streptococci. We demonstrate that these IDRs are glycosylated with glucose by glycosyltransferases GtrB and PgtC2 in Streptococcus pyogenes and Streptococcus pneumoniae, and with N-acetylgalactosamine by a Pgf-dependent mechanism in Streptococcus mutans. The absence of glycosylation leads to a defect in biofilm formation under ethanol-stressed conditions in S. mutans. We link this phenotype to the C-terminal IDR …

Enhanced And Interpretable Prediction Of Multiple Cancer Types Using A Stacking Ensemble Approach With Shap Analysis, Shahid Mohammad Ganie, Pijush Kanti Dutta Pramanik, Zhongming Zhao

Faculty, Staff and Student Publications

Background: Cancer is a leading cause of death worldwide, and its early detection is crucial for improving patient outcomes. This study aimed to develop and evaluate ensemble learning models, specifically stacking, for the accurate prediction of lung, breast, and cervical cancers using lifestyle and clinical data.

Methods: 12 base learners were trained on datasets for lung, breast, and cervical cancer. Stacking ensemble models were then developed using these base learners. The models were evaluated for accuracy, precision, recall, F1-score, AUC-ROC, MCC, and kappa. An explainable AI technique, SHAP, was used to interpret model predictions.

Results: The stacking …

Bridging Social And Ecological Science To Create Spatially Explicit Models Of Human-Caused Mortality Of Carnivores, Jeremy T. Bruskotter, Neil H. Carter, Richard Berl, Joseph Hinton, Jazmin Murphy, L Mark Elbroch, John A. Vucetich

Michigan Tech Publications

Research indicates that human-caused mortality (HCM) is a key factor limiting numerous large carnivore populations. However, efforts to represent HCM in spatially explicit models have generally been limited in scope-often relying on proxies, such as road or human density. Yet such efforts fail to distinguish different sources of HCM, which can arise from different antecedent processes. We offer a systems-based conceptual framework for understanding the antecedents of HCMs that is grounded in theory from the social and behavioral sciences. Specifically, we first explain how HCMs are usefully distinguished into four types (e.g., accidental, harvest, illicit, control actions), then discuss how …

Comparing Parasitism And Resistance To Flow In Two Populations Of Elimia Virginica, Morgan G. Hicok, Abbie Tomba, Kate Green

Departmental Honors & Graduate Capstone Projects

Snails are important in freshwater ecosystems as primary consumers and are good indicators of the stability of a habitat. Trematodes are parasitic flatworms that infect freshwater snails and can cause changes in metabolic function and growth. Flow rates and water levels are now more variable due to climate change, increasing stress and dislodgment in the snail population. This study investigates how parasites, shell morphology, and native flow environment influence resistance to disturbance. Elimia populations were sampled for differences in parasitism, shell morphology, and ability to withstand high flow environments in two different rivers. Sample sites at the Potomac River were …

Bacterial Microbiomes In Different Depths Of Sand At The Mississippi Gulf Coast, Hays S. Roth

Honors Theses

Microbial communities in sand play essential roles in their ecosystems, yet little is known about how bacterial diversity and function vary across different sand depths. This study investigated bacterial microbiomes at varying depths (0, 10, 20, 30, and 40 cm) on Biloxi East Beach, on the Mississippi Gulf Coast, using 16S rRNA gene sequencing and assays of extracellular enzyme activity. 11,161 amplicon sequence variants (ASVs) were identified across all samples, with the most abundant bacterial phyla being Planctomycetota, Gammaproteobacteria, and Bacteroidota. Depth had a significant impact on bacterial community composition, with surface layers having more diverse bacterial communities. Microbial diversity …