Life Sciences Commons^™

Crispy Not Risky: Effects Of Environmental Conditions On Low-Moisture Food Persistent Bacterial Pathogens, Manita Adhikari

Graduate Theses and Dissertations

Low-moisture foods (LMFs) were not historically seen as safety risks due to their ability to inhibit pathogen growth, but evidence shows pathogens can survive in LMFs long-term, causing outbreaks and recalls. Previous studies have lacked the ability to replicate real-world contamination scenarios in LMF processing environments. This research aimed to develop inoculation methods to form LMF persistent bacterial populations (LMF PBPs) and assess pathogen responses to environmental factors, culturing methods (broth vs. lawn), and matrix type and ratio. Inoculation methods tested were “direct” (combining bacterial culture and powder on a stainless-steel coupon) and “slurry” (premixing culture and powder). Matrices included …

Comparisons Between Traditional And Gluten-Free Cookies In Sensory Attributes, Acceptance, And Evoked Emotions, Eniola Ola

Graduate Theses and Dissertations

The rise in food allergies and intolerances, notably conditions like Celiac disease, as well as a general shift of consumers to a more health-conscious lifestyle has significantly increased the demand for gluten-free products. Consumers increasingly seek gluten-free products, yet these alternatives often face challenges in replicating the sensory qualities of traditional gluten-containing foods. This study explores the sensory attributes, emotional responses, and labeling impacts on consumer perception of gluten-free and gluten-containing cookies. The main objective of this thesis was to address the gap in research on sensory evaluation of gluten free foods, specifically in terms of commercially available products. The …

Empowering Diversity: A Comprehensvie Approach To Minority Risk Management Education, Jahqethea Johnson

Applied Science Program: Theses

Federal programs are pivotal to the foundation of the United States agricultural sector. Program payments impact the economic well-being of agricultural producers, yet accessibility, outreach and education disparities remain prevalent among socially disadvantaged producer and agriculturists. From 2020-2024, an average of $21.7 billion dollars in federal agricultural payments have been paid to producers. Although federal funding historically supports commodity crops, livestock producers also depend on a distinct set of federal risk management programs, which are often less visible but pertinent for operational sustainability. There is a growing focus on the need for addressing disparities faced by socially disadvantaged producers and …

Identification Of Antigens For Food Allergy And Food Allergen Detection, Ellenor Sell

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Antibody-based allergen testing is an essential part of allergen management in the food industry. These methods directly detect one or more molecules of the allergenic foodstuff (target’ molecule(s)) and the presence of the allergenic foodstuff is inferred. The identity of these target molecules is crucial to the performance of the method and the interpretation of results. The goal of this study was to develop protein/antibody capture methodology for the identification of antibody binding partners using mass spectrometry.

This study is broken down into three separate projects: the characterization of the antigen-antibody complexes present in sandwich ELISAs, LFDs, and human sera. …

Functional Analysis Of Chromatin Remodeler Csb In Parp1/2- Mediated Oxidative Dna Lesion Repair, Rabeya Bilkis

Biomedical Sciences ETDs

The ATP-dependent chromatin remodeler Cockayne syndrome protein B (CSB) is essential for maintaining genome integrity. Mutations in CSB are the primary cause of Cockayne syndrome (CS), a premature aging disorder with severe sun sensitivity and neurodevelopmental symptoms. However, the precise mechanisms underlying the disease etiology remain poorly understood. Given the critical roles of oxidative stress in aging and neurodegenerative disorders, this research sought to determine the mechanisms of CSB’s functions in oxidative DNA damage repair.

In the first aim, we investigated how CSB participates in PARP1/2-mediated oxidative DNA repair. We showed that PARP1 and PARP2 recruit CSB to oxidized chromatin …

Precision Proteogenomics Reveals Pan-Cancer Impact Of Germline Variants, Fernanda Martins Rodrigues, Nadezhda V Terekhanova, Kathleen J Imbach, Karl R Clauser, Myvizhi Esai Selvan, Isabel Mendizabal, Yifat Geffen, Yo Akiyama, Myranda Maynard, Tomer M Yaron, Yize Li, Song Cao, Erik P Storrs, Olivia S Gonda, Adrian Gaite-Reguero, Akshay Govindan, Emily A Kawaler, Matthew A Wyczalkowski, Robert J Klein, Berk Turhan, Karsten Krug, D R Mani, Felipe Da Veiga Leprevost, Alexey I Nesvizhskii, Steven A Carr, David Fenyö, Michael A Gillette, Antonio Colaprico, Antonio Iavarone, Ana I Robles, Kuan-Lin Huang, Chandan Kumar-Sinha, François Aguet, Alexander J Lazar, Lewis C Cantley, Urko M Marigorta, Zeynep H Gümüş, Matthew H Bailey, Gad Getz, Eduard Porta-Pardo, Li Ding

Faculty, Staff and Student Publications

We investigate the impact of germline variants on cancer patients' proteomes, encompassing 1,064 individuals across 10 cancer types. We introduced an approach, "precision peptidomics," mapping 337,469 coding germline variants onto peptides from patients' mass spectrometry data, revealing their potential impact on post-translational modifications, protein stability, allele-specific expression, and protein structure by leveraging the relevant protein databases. We identified rare pathogenic and common germline variants in cancer genes potentially affecting proteomic features, including variants altering protein abundance and structure and variants in kinases (ERBB2 and MAP2K2) impacting phosphorylation. Precision peptidome analysis predicted destabilizing events in signal-regulatory protein alpha (SIRPA) and glial …

Prevalence And Patterns Of Opioid Use In Chronic Pancreatitis, Anna Evans Phillips, Darwin L Conwell, Shuang Li, Jami L Saloman, Phil A Hart, Evan L Fogel, Santhi Swaroop Vege, Dana K Andersen, William E Fisher, Christopher E Forsmark, Stephen Pandol, Walter G Park, Mark D Topazian, Stephen K Van Den Eeden, Jose Serrano, Liang Li, Dhiraj Yadav

Faculty, Staff and Student Publications

Introduction: Opioids are used to treat pain in chronic pancreatitis (CP), but little is known about current use patterns. The aim of this study was to characterize the utilization of opioids and associations with clinical characteristics in adult patients with CP.

Methods: This cross-sectional analysis used baseline data from participants with definite CP enrolled in a cohort study in the United States (PROspective Evaluation of CP for EpidEmiologic and Translational StuDies). Data on demographics, pain medication use, healthcare utilization, disability, and pain patterns were systematically collected in case report forms while quality of life was assessed with patient-reported outcome instruments. …

Structure Disorder And Magnetic Behavior Of An Olivine-Type Cathode Material, Hamida Hassan, Madalynn Marshall

Symposium of Student Scholars

Our research investigates the structure disorder and magnetic behavior of Li(Mn,Fe)PO₄, an olivine-type material relevant for lithium-ion battery applications. Using single-crystal neutron diffraction at Oak Ridge National Laboratory, we precisely determined Mn and Fe occupancy, revealing a 56% Fe and 44% Mn distribution at the atomic 4c site within the Pnma space group. Additionally, we observed significant lithium site vacancies (78% occupied), influencing the material's electrochemical and magnetic properties. The varying Mn/Fe ratio affected spin reorientation transitions, shifting from antiferromagnetic alignment along the a-axis to the b-axis. Our findings provide crucial insights for optimizing olivine-based cathodes, enhancing energy …

Assessing The Osmoregulatory Capabilities Of American Alligator Lingual Glands, Benjamin Angalet, Nicholas S. Green

Symposium of Student Scholars

Crocodilians inhabit a wide variety of aquatic, marine, and estuarine habitats on 4 continents. Saltwater-adapted species and populations face considerable osmoregulatory challenges in maintaining homeostasis with respect to plasma salt [NaCl] concentration. In addition to the kidneys and cloaca found in all crocodilians, crocodiles possess a salt-secreting lingual gland whose presence and function is less understood in other crocodilians. This study investigates the lingual gland anatomy, physiology, and potential function of American alligator (Alligator mississippiensis) populations exposed to varying salinity levels. At each of four sites (Jekyll Island, Sapelo Island, Okefenokee NWR, and Banks Lake NWR), we will capture 12 …

Can A Ceh-27/Nkx2.1 Transgene Rescue Ceh-27 Neurodevelopmental Defects?, Meryl Gilmore, Martin L. Hudson

Symposium of Student Scholars

When the development of an organism’s nervous system is interrupted or altered, it can significantly impact that organism’s ability to survive and function properly. In our lab, we use a species of nematode called Caenorhabditis elegans as a model organism to characterize the roles of important transcription factors in human neurodevelopmental disorders such as attention deficit hyperactivity disorder (ADHD). Utilizing C. elegans makes analyzing this process in a lab very easy for many reasons; they are very small, have a rapid life cycle, invariant cell lineage, transparent bodies, and most importantly, around 80% of their genes have human orthologs. In …

Sustainable Smart Farming Device With Leafit Adaptive Growth Technology, Saville Atkins, Anthony Iwejuo, Julian Pitts, Luis Mercado, Rachnicha Rojjhanarittikorn, Sandip Das, Hai Ho

Symposium of Student Scholars

For farmers, gardeners, and horticulture enthusiasts worldwide, one immutable reality is that maintaining a consistent physical presence to care for plants is not always feasible. In addition, different plants have unique needs for watering, nutrients, and environmental conditions to thrive. Failing to meet these specific needs can result in poor plant health, reduced yields, and inefficient resource usage. In this research project, we have designed and developed ‘LeaFit’ – a cutting-edge Internet of Things (IoT) device that offers a sophisticated and sustainable smart farming and gardening solution. Equipped with intelligent soil moisture, ambient temperature, humidity, and light sensors, LeaFit autonomously …

Predicting Healthcare Service Quality Based On A Kalman-Optimized Bi-Lstm-Inspired Deep Learning Model, Mohammed K. Al-Khafaji, Eman S. Al-Shamery

Karbala International Journal of Modern Science

Health is one of the most important aspects of human well-being, and access to high-quality healthcare is essential for a good quality of life. Providing top-level health services at all times is crucial. However, the research in healthcare poses significant challenges due to the diversity and variations of medical practices across different hospitals. This paper aims to tackle the challenge of data missing and scattering during data collection. Then, the quality of services (QoS) offered by healthcare facilities will be analyzed and predicted from the patient's perspective. The model begins preprocessing data by data cleaning, handling missing values, and scattering …

An Analysis Of New York’S Drug Policies: Comparing The Effectiveness Of Punitive Punishment Versus Rehabilitation In Preventing Recidivism, Zed Agarwal

Student Publications & Research

The persistent failure of punitive drug policies, exemplified by the Rockefeller Drug Laws, necessitates a critical re-examination of how society addresses drug offenses. For decades, New York State has been at the forefront of both the implementation of harsh drug sentencing laws and the subsequent development of innovative rehabilitation alternatives. The trajectory of this policy evolution reveals a profound shift in understanding the nature of addiction and the most effective approaches to reducing drug-related crime. When New York enacted the Rockefeller Drug Laws in 1973, they represented the epitome of punitive drug policy by imposing mandatory minimum sentences of fifteen …

Crónicas De Gastronomía Ancestral De La Provincia De Ubaté (Cundinamarca), Johanna Andrea Gil Palacios, Nancy Milena Valiente Triana, Nohora Liliana Agudelo Rodríguez, Carlos Alfonso López Urquina, Cristian Ballén Guarín, John Henry Vásquez Calderón

Institucional

Este libro es un viaje maravilloso que conduce al lector a comprender la estrecha relación entre territorio y gastronomía. Cada accidente geográfico representa un reto de sus pobladores que potencia su creatividad para sobrevivir e implica el esfuerzo para que broten frutos que se puedan llevar a la mesa, en sendas preparaciones que se van heredando entre generaciones. Las personas cuentan llenas de orgullo las gestas que han vivido en torno a la comida, las reuniones familiares, las fiestas patronales, y las convierten en la mejor vitrina de su identidad y la celebración de las cosechas. Es un verdadero placer …

Assessing The Behavioral Impact Of Pyridostigmine Bromide In Rats, Noah A. Martin

Honors Theses

Pyridostigmine bromide (PB) is an organophosphate (OP) nerve agent prophylactic used to protect warfighters against chemical warfare agents. OPs inhibit the neural enzyme acetylcholinesterase (AChE) in the brain. This leads to the buildup of acetylcholine, causing respiratory failure, seizures, and death. PB functions by inhibiting ~30% of peripheral AChE temporarily, protecting the enzymes so that the body is able to restore sufficient cholinergic function post-exposure. PB does not cross the blood-brain barrier, though it may still indirectly affect toxicity in the brain due to repeated AChE inhibition throughout treatment, or by inhibition of non-target ChE’s in the blood. The aim …

Where Is Your Crop Insurance Agent? Understanding The Geographical Distribution Of Agents, Cory Walters, Nathan Delay

Cornhusker Economics

Following the modifications to the Standard Reinsurance Agreement (SRA) in 2010, there was limited understanding of the impact of policy changes on agent availability. Our objective is to construct a model of the equilibrium supply of crop insurance agents and to test hypotheses regarding the factors influencing agent concentration, such as commissions, competition, and risk. We developed a theoretical equilibrium model of the federal crop insurance market, which encompasses three tiers: insurance companies, agents, and farmers. The model incorporates key features of the federal program, including government-set premiums and the stipulation that agents cannot refuse coverage or modify premiums for …

Seasonal Detection Of Coliphages In Freshwater Bodies At Coastal Carolina University, Ella Caldwell

Honors Theses

Bacteriophages, commonly referred to as phages, are non-living viruses that only infect bacteria. As the most abundant biological entities on Earth, understanding their role in regulating microbial populations is essential. This ongoing research aims to identify naturally occurring bacteriophages that could effectively control bacteria blooms. The primary objective of this study is to detect coliphages on Coastal Carolina University's campus and determine their viral families. Coliphages are a subgroup of bacteriophages that specifically infect coliform bacteria. Water samples were collected across multiple sites on campus, and polymerase chain reaction (PCR) was employed to amplify the viral DNA from the potential …

Gonadal Absence Of Ceh-22: Degradation Of Ceh-22 In The Gonads Of Caenorhabditis Elegans, Andreya C. White

Undergraduate Theses

The reproductive system of hermaphrodite Caenorhabditis elegans (C. elegans) comprises two gonadal arms, each with a terminating distal tip cell (DTC), connected by a common uterus. The DTC has two functions: leader and niche. In C. elegans, ceh-22/nkx2,5 has been found to work together with Wnt signaling to determine the fates of the DTC (Lam et al., 2006). This is an indication that ceh-22 aids in the specification of DTCs. Our research aims to determine the specific function of ceh-22 in the gonad of both male and hermaphrodite C. elegans. This will be accomplished by observing …

Can Chaperones Promote Protein Splicing?, Hazel Thomas

Honors College Theses

Inteins are a mobile genetic element hypothesized to function as regulatory molecules in microbes. They bear a homing endonuclease domain for genome traversal, as well as specific residues allowing for protein splicing. In the protein splicing reaction, the intein is removed and the flanking residues, termed exteins, are ligated together with a peptide bond to form a functional host protein. Due to their interruption prior to splicing, inteins prevent a host protein from functioning until the intein ligates the two exteins. To measure factors that regulate protein splicing in vivo, an intein-based biosensor based on kanamycin resistance (K …

Degradation Of Vascular Networks In A Huvec Model Of Dm1, Bonnie E. Butler

Departmental Honors & Graduate Capstone Projects

Myotonic dystrophy type 1 (DM1) is a genetic disease that causes muscle wasting and affects multiple organ systems. DM1 is caused by expanded CTG repeats in the 3’ untranslated region of the dystrophia myotonica protein kinase (DMPK) gene (Harper, 2001). Skeletal muscle relies on capillaries for nutrient delivery and waste clearance (Olfert, 2016). Skeletal muscle and capillaries communicate via a variety of chemicals, including PDGF-BB which both skeletal muscle and endothelial cells secrete and have receptors for (Hamaguchi, 2023). Platelet derived growth factor receptor β (PDGFRβ), when bound to platelet derived growth factor BB (PDGF-BB), induces angiogenesis (Wang, 2012). In …

Raíces Y Recuerdos: Plantas Ornamentales Para Entornos Saludables, Adriana Hernández Bustos, María Janeth Camargo Garzón, María Victoria Rojas Martínez, Segundo Leonardo Cortes López

Ciencias de la Salud

El reino vegetal es un universo lleno de vida, colores, texturas, aromas y beneficios que trascienden a través del tiempo. Es un aliado perfecto para el trabajo conjunto e intergeneracional; para este caso, las plantas no solo embellecen los paisajes y espacios, sino que tienen además el poder de mejorar nuestra calidad de vida, especialmente cuando se integran en actividades terapéuticas y sociales con personas mayores.

Intermittent Fasting And Cardiometabolic Health In Adults With Obesity: A Scoping Review, Tri Siswati, Lathifa Zahra Putri Nugroho, Natasya Nurul Gina, Almira Sitasari, Agus Wijanarka

Indonesian Journal of Public Health Nutrition (IJPHN)

Obesity is a significant global health challenge, with adverse impacts on cardiometabolic health such as hypertension, dyslipidemia, and insulin resistance. One promising intervention in obesity management is intermittent fasting (PI). However, scientific evidence on the impact of IF on cardiometabolic health is still limited. This study used a scoping review design to evaluate the association between IF and cardiometabolic health in obese adults. Reference sources are available in English at least abstract between 2015–2023 as well as from PubMed and Google Scholar web sources. The search keywords on PubMed are "Adult AND intermittent fasting AND cardiometabolic" and on Google Scholar …

The Effect Of Calisthenics Training On Estimated Vo₂Max Values In College Students, Rayhan Amer Imran, Triyanti Triyanti, Fathimah Sulistyowati Sigit, Mury Kuswari

Indonesian Journal of Public Health Nutrition (IJPHN)

Cardiorespiratory fitness (VO₂max) among university students is worryingly low, with more than 50% of students categorized as unfit (<41.7 mL/kg/min). This study was conducted to determine the effect of calisthenic training on estimated VO₂max values using a quasi-experimental study design on 21 male students of the Faculty of Public Health, University of Indonesia from August to October 2024. Subjects were divided into 2 groups: the intervention group (n=10) and the control group (n=11). The intervention group performed treatment in the form of calisthenics exercise for 40 minutes, and the control group received running exercise treatment for 20 minutes, with both exercises done twice a week for 4 consecutive weeks. Body weight, height, body mass index, estimated VO₂max values, body fat percentage, muscle mass, academic stress levels, sleep quality and macronutrient intake data were measured pre-and-post training and were analyzed using independent and dependent t-tests. The results showed a significant (p<0.05) difference in change on the average estimated VO₂max values between the intervention group (3.5 mL/kg/min) and the control group (11.4 mL/kg/min). It can be concluded that the changes in estimated VO₂max values were likely more effective in the running group compared to the calisthenics group.

Factors Related To The Incidence Of Hypertension Among People Above 18 Years At The Cibatu Public Health Center, Bekasi Regency, Verizka Azra, Yustiyani Yustiyani, Minsarnawati Minsarnawati, Catur Rosidati

Indonesian Journal of Public Health Nutrition (IJPHN)

Hypertension is a non-communicable disease that still becomes a public health issue. The percentage of hypertension cases at Cibatu Public Health Center increased from 31.7% in 2021 to 37% in 2022. Based on a preliminary study, hypertension was found to be the most common non-communicable disease at Cibatu Public Health Center. This study aimed to identify factors associated with the incidence of hypertension among individuals aged 18 years and older at Cibatu Public Health Center, Bekasi Regency, in 2024.We conducted a cross-sectional study in May involving 121 respondents. This study used standardized questionnaires that had been validated in previous research, …

The Relationship Between Ultra-Processed Food (Upf) Consumption, Sedentary Behavior, And Overweight Status Among Students At Sman 1 Tangerang, Banten, Indonesia, Husna Dzakya Azzahra, Zenia Elsa Fitri, Imas Arumsari

Indonesian Journal of Public Health Nutrition (IJPHN)

Overweight is a condition where excess body fat accumulates, leading to increased risks of diseases such as heart disease, stroke, diabetes, hypertension, arthritis, and cancer. The prevalence of overnutrition in adolescents aged 16-18 years has been rising over the years, from 5.7% in 2013 to 9.5% in 2018. This study aims to analyze the relationship between Ultra-Processed Food (UPF) consumption and sedentary behavior on overweight status among students at SMAN 1 Tangerang. A cross-sectional design, data were collected through interviews with 114 respondents using the SQ-FFQ Ultra-Processed Food questionnaire and the Sedentary Behavior Questionnaire (SBQ), with quota sampling employed. The …

Exploring The Non-Communicable Disease Burden In Indonesia – Findings From The 2023 Health Survey, Akifa Laila Rusyda

Indonesian Journal of Public Health Nutrition (IJPHN)

The present study rigorously examines the correlation between obesity, high-risk dietary consumption, and unhealthy lifestyles with the prevalence of non-communicable diseases (NCDs) in Indonesia. The study employed a cross-sectional study design using secondary data from the 2023 Indonesian Health Survey, analyzing 38 units (n) representing Indonesia's provinces in 2023. The correlation analysis, conducted using Pearson's test with a significance level of 95% (α<0.05), revealed significant regional disparities in the prevalence of NCDs, dietary consumption, and lifestyle factors across Indonesia. Moreover, the findings reveal a statistically significant positive correlation between obesity, high-risk food consumption, and lifestyle risk factors with the prevalence of several NCDs, including diabetes mellitus, heart disease, hypertension, and chronic kidney disease. These results underscore the potential impact of our research on public health in Indonesia. The results highlight also the urgent need for targeted public health initiatives, such as policies promoting healthier food choices, controlling the food environment, encouraging physical activity, and supporting smoking cessation to mitigate the growing burden of NCDs in Indonesia.

Maternal Dietary, Nutritional Status, And Its Association With Low-Birth Weight: A Scoping Review, Tri Siswati, Devi Septia Ningrum, Adinda Safitri, Almira Sitasari

Indonesian Journal of Public Health Nutrition (IJPHN)

Maternal diet and nutritional status during pregnancy influence birth outcomes. This review article aims to synthesize key studies examining the relationship between maternal dietary intake, nutritional status, and the occurrence of low birth weight (LBW). This study applies a scoping review from PubMed and Google Scholar (2018–2023). Observational and experimental studies were included. Articles met the criteria if they involved pregnant women aged 17+, human studies, full-text availability, and were in English or Indonesian. Fourteen studies met the inclusion criteria and were analyzed. The findings revealed that maternal intake of essential macronutrients, including energy and protein, along with key micronutrients …

Plant Diversity Dynamics Over Space And Time In A Warming Arctic, Mariana García Criado, Isla H. Myers-Smith, Anne D. Bjorkman, Sarah C. Elmendorf, Signe Normand, Peter Aastrup, Rien Aerts, Juha M. Alatalo, Lander Baeten, Robert G. Björk, Mats P. Björkman, Noémie Boulanger‐Lapointe, Ethan E. Butler, Elisabeth J. Cooper, J. Hans C. Cornelissen, Gergana N. Daskalova, Belen Fadrique, Bruce C. Forbes, Greg H. R. Henry, Robert D. Hollister, Toke Thomas Høye, Ida Bomholt Dyrholm Jacobsen, Annika K. Jägerbrand, Ingibjörg S. Jónsdóttir, Elina Kaarlejärvi, Olga Khitun, Kari Klanderud, Tiina H. M. Kolari, Simone I. Lang, Nicolas Lecomte, Jonathan Lenoir, Petr Macek, Julie Messier, Anders Michelsen, Ulf Molau, Robert Muscarella, Marie-Louise Nielsen, Matteo Petit Bon, Eric Post, Katrine Raundrup, Riikka Rinnan, Christian Rixen, Ingvild Ryde, Josep M. Serra‐Diaz, Gabriela Schaepman‐Strub, Niels M. Schmidt, Franziska Schrodt, Sofie Sjögersten, Manuel J. Steinbauer, Lærke Stewart, Beate Strandberg, Anne Tolvanen, Craig E. Tweedie, Mark Vellend

Wildland Resources Faculty Publications

The Arctic is warming four times faster than the global average¹ and plant communities are responding through shifts in species abundance, composition and distribution^2,3,4. However, the direction and magnitude of local changes in plant diversity in the Arctic have not been quantified. Using a compilation of 42,234 records of 490 vascular plant species from 2,174 plots across the Arctic, here we quantified temporal changes in species richness and composition through repeat surveys between 1981 and 2022. We also identified the geographical, climatic and biotic drivers behind these changes. We found greater species richness …

Different Effects Between Trigeminal Sensory And Vagal Visceral Input On Salivary Gland Blood Flow, Ratna Ramadhani, Toshiya Sato, Hisayoshi Ishii

Journal of Dentistry Indonesia

Objective: The purpose of the present study was to evaluate the different effects of trigeminal sensory and vagal-visceral inputs on blood flow (BF) in the submandibular gland (SMG). Methods: Ten to eleven-week-old Wistar rats were anesthetized with urethane (1.0 g/kg) and artificially ventilated. The femoral artery was cannulated for systemic arterial blood pressure (SABP) measurement. The cervical sympathetic trunk (CST) on both sides and the cervical vagus nerve (CVN) on the right side were cut before the stimulation of the left abdominal vagus nerve (AVN). The CVN and lingual nerve (LN) were stimulated after cutting the CST and CVN. AVN, …

Network-Based Clustering Unveils Interconnected Landscapes Of Genomic And Clinical Features Across Myeloid Malignancies, Fritz Bayer, Marco Roncador, Giusi Moffa, Kiyomi Morita, Koichi Takahashi, Niko Beerenwinkel, Jack Kuipers

Faculty, Staff and Student Publications

Myeloid malignancies exhibit considerable heterogeneity with overlapping clinical and genetic features among subtypes. We present a data-driven approach that integrates mutational features and clinical covariates at diagnosis within networks of their probabilistic relationships, enabling the discovery of patient subgroups. A key strength is its ability to include presumed causal directions in the edges linking clinical and mutational features, and account for them aptly in the clustering. In a cohort of 1323 patients, we identify subgroups that outperform established risk classifications in prognostic accuracy. Our approach generalises well to unseen cohorts with classification based on our subgroups similarly offering advantages in …